College
University of Texas, BA, Biochemistry, 1984

Medical School
University of Texas Southwestern Medical School, MD, 1988

Residency Program
General Surgery, UT Southwestern Medical School
Parkland Memorial Hospital, Dallas, TX, 1990
Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, 1994

Fellowship: Location
University of Pittsburgh, Pittsburgh, PA, 1995

Fellowship: Area of Concentration
Head and Neck Oncology and Cranial Base Surgery

Board Certified
Otolaryngology, 1995

Year Appointed to Penn Faculty
2003

Other Appointments
University of Pennsylvania School of Medicine and Health System
Gabriel Tucker Professor and Chairman, Dept. Otorhinolaryngology-HNS 2003 – present
Director, Residency Program, Dept. Otorhinolaryngology-HNS 2003 - 2005
Co-Director, Head and Neck Cancer Center 2003 - present
Director, Division of Head and Neck Surgery 2003 - 2004
Professor, Abramson Cancer Center 2003 - present
Professor, Department of Neurosurgery

Johns Hopkins University School of Medicine  
Assistant Professor, Department of Otolaryngology - Head and Neck Surgery 1995 - 1997 Assistant Professor, Department of Oncology 1996 - 1997
Faculty Member, Markey Graduate Program in Cellular and Molecular Biology 1997 - 1999
Director, Gene and Molecular Therapy Division, Dept. of Otolaryngology-HNS 1997 - 1999
Associate Professor, Department of Otolaryngology – HNS 1998 - 1999
Associate Professor, Department of Oncology 1998 - 1999

University of Maryland School of Medicine
Director, Division of Otolaryngology - Head & Neck Surgery 1999 - present
Director, Residency Program, Otolaryngology-Head & Neck Surgery
Director, Head & Neck Cancer Center
Professor of Surgery 2001 - present
Professor, Greenebaum Cancer Center
Director, Head & Neck Oncology Research Program
Co-Director, Center for Skull Base Surgery 2001 - present
Associate Director, Univ. Maryland Greenebaum Cancer Center 2003
Professor and Chairman, New Department Otolaryngology-Head and Neck Surgery 2003 (July)

Areas of Expertise
Robotic Head and Neck and Skull Base Surgery
Skull base surgery
Head and neck cancer
Thyroid surgery
Minimally invasive endoscopic sinus and skull base surgery

Positions Held in Major Societies (Past & Present)
Professional Relations & Public Education Committee,
American Academy Otolaryngology-Head and Neck Surgery
Research Committee for the American Head & Neck Society
Association for Research in Otolaryngology Physician Research Training Committee
Chairman, Otolaryngology Section, International College of Surgeons
Board of Trustees, National Advanced Cranio-Maxillofacial Forum
AO ASIF North American Cranio-Maxillofacial Education Committee
American Academy of Otolaryngology Head and Neck Surgery
Cell Transplant Society, Founding Member
American Society for Gravitational and Space Biology
American Association for Cancer Research
Maryland Society of Otolaryngology
American Association for the Advancement of Science
American Society for Gene Therapy
Fellow, International College of Surgeons
Fellow, American College of Surgeons
Fellow, American Head and Neck Society
Society of University Otolaryngologists - Head & Neck Surgeons
Physician / Scientist Member; Russian-American Cancer Alliance
Editor-in-Chief, ORL, Journal of Oto-Rhino-Laryngology
Editorial Board, Skull Base Surgery, Otolaryngology-Head & Neck Surgery
International Editorial Board, Otolaryngology-Head & Neck Surgery
Editorial Board, Laryngoscope

Research Grants
*RO1 DE14562 (NIH) Adenovirus Limitations and Tumor Targeted Gene Therapy $1,225,000 direct costs; total costs $1,782,000. (1/03-1/08) [score 140, percentile 6.2] Sponsor: NIH/NIDCR
Role: Principle Investigator 20%

MRN-Targeted Chemosensitization for Oral Cancer (in vitro)
$300,000.00 (direct cost); (7/02-6/05)
Sponsor: Flight Attendant Medical Research Institution
Role: Co-Investigator P.I.: Daqing Li, M.D. (UPENN)

R03-DE-15428-1A2 The Effect of Oral Lactoferrin on Head & Neck Cancer
$100,000 (direct costs); (3/05 – 2/07)
Sponsor: NIH/NIDCR
Role: Co-Investigator 3% P.I.: Jeffrey Wolf, M.D. (Univ. MD)

R01-CA-107621 Engineering Polymers For Gene Therapy of Head and Neck Cancer $1,225,000 (direct costs); (3/05 – 2/10) [score 156, percentile 8.0]
Sponsor:
Role: Co-Investigator 10% P.I.: Hamid Ghandehari, Ph.D. (Univ. MD)

Correlation of Chronic Sinusitis and Tobacco Smoke (Clinical Innovator Award) $300,000.00 (direct cost); (7/05-6/08)
Sponsor: Flight Attendant Medical Research Institution
Role: Co-Investigator P.I.: Jeffrey Wolf, M.D. (Univ. MD)

R01 CA076417 (NIH) Human and Murine Models of BRCA1 tumorigenesis.
$1,125,000 direct costs; total costs; $1,676,250 (7/03 - 6/08)
Role: Principle Investigator 15%

Honors & Awards
Phi Beta Kappa Honor Society, 1983
Phi Kappa Phi Honor Society, 1983
Golden Key Honor Society, 1983
Magna Cum Laude Graduate, 1984
UT Southwestern Clinical Rotations' Ranking:Number 1 of 199, 1988
First Place Resident Research Award, Texas Association of Otolaryngology, 1992
Charles Dickson Resident Research Award for Laboratory Science, 1992
Resident Research Award-Runner Up, Triological Society Southern Section, 1993
Second Place Resident Research Award, Texas Association Otolaryngology, 1993
First Place Resident Research Award, Texas Association of Otolaryngology, 1994
The American Cancer Society Clinical Oncology Fellowship Award, 1994
International College of Surgeons Research Award 1995
First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery, 1997
First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery, 1998
First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery, 2001
Honor Award, American Academy of Otolaryngology - Head and Neck Surgery, 2001
Honorary Master of Arts, University of Pennsylvania, 2004

Selected Publications
O'Malley, B.W., Jr. , Sikes, M.L., Adams, R.M., Finegold, M.J., Ledley, F.D. Somatic gene therapy targeted to the thyroid: viral mediated gene transfer in animal models. Transplantation Proceedings. 1992;24/6:2973-2974.

O'Malley, B.W., Jr., Finegold, M., Ledley, F.D. Autologous, Orthotopic Follicular Cell Transplantation: A Surgical Component of ex vivo Somatic Gene Therapy. Otolaryngology-Head and Neck Surgery. 1993;108(1):51-62.

O'Malley, B.W., Jr., Adams, R.M., Sikes, M.L., Ledley, F.D. Retroviral-mediated gene transfer into canine thyroid using an ex vivo strategy. Human Gene Therapy. 1993;4:171-177.

O'Malley, B.W., Jr., and Ledley, F.D. DNA and retroviral mediated gene transfer into follicular cells in vitro: progress towards gene therapy of the thyroid. The Laryngoscope. 1993;103(10): 1084-1092.

O'Malley, B.W., Jr., Adams, R.M., Ledley, F.D. Gene Transfer into Human Thyroid Follicular Cells. The Laryngoscope. 1994;104:1330-1336.

Sikes, M.L., O'Malley, B.W., Jr., Finegold M.J., Ledley F.D. In Vivo Gene Transfer into Rabbit Thyroid Follicular Cells by Direct DNA Injection. Human Gene Therapy 1994;5:837-844.

Wang, Y.L., O'Malley, B.W., Jr., Tsai, S., Tsai, M., O'Malley, B.W. A Novel Regulatory Switch Designed for Gene Therapy. Proceedings Nationalof the National Academy Science 1994;91:8180-8184.

O'Malley, B.W., Jr., Janecka, I.P. Evolution of Outcomes in Cranial Base Surgery. Seminars in Surgical Oncology 1995;11:1-7.

O'Malley, B.W., Jr., Li, D., Turner, D. Hearing Loss and Cochlear Abnormalities in the Congenital Hypothyroid (hyt/hyt) Mouse. Hearing Research 1995;88:181-189.

Yovandich, J., O'Malley, B.W., Jr., Sikes, M.L., Ledley, F.D. Gene Transfer to Synovial Cells by Intra-Articular Administration of Plasmid DNA Human Gene Therapy 1995;6:603-10.

O'Malley, B.W. Jr., Chen, S.H., Schwartz, M.R., Woo, S.L.C. Adenovirus-Mediated Gene Therapy for Head and Neck Cancer in a Nude Mouse Model. Cancer Research 1995;55:1080-1085.

O'Malley, B.W., Jr., Cope, K.A., Chen, S-H., Schwartz, M.R., Woo, S.L.C. Combination Gene Therapy for Oral Cancer in a Murine Model. Cancer Research 1996;56:1737-1741.

O'Malley, B.W., Jr., Cope, K.A., Johnson, C.S., Schwartz, M.R.. A New Immunocompetent Murine Model for Oral Squamous Cell Carcinoma. Archives Otolaryngol Head Neck Surg. 1997;123:20-24.

Sewell DA, Li D, Duan L, O'Malley BW, Jr., Optimizing an adenoviral mediated "suicide gene" strategy for human application in the treatment of head and neck cancer. The Laryngoscope 1997;107(11):1490-1495.

O'Malley BW, Jr., Sewell DA, Li D, Kosai K, Chen S-H, Woo SLC, Duan L. The Role of Interleukin-2 in Combination Adenovirus Gene Therapy for Head and Neck Cancer Molecular Endocrinology 1997;11(6):667-673.

O'Malley BW, Jr., And Li D. Combination Gene Therapy for Salivary Gland Cancer. Ann New York Acad of Sci 1998;842:163-170.

Xiang M, Gan L, Li D (equal first authors), Chen Z, Zhou L, O’Malley BW, Jr., Klein W, Nathans J. Essential Role of POU-Domain Factor Brn-3c in Auditory and Vestibular Hair Cell Development. Proceedings of the National Academy of Sciences 1997;94:9445-9450.

Gillespie MD, O’Malley BW Jr., (corresponding author), Frances H. An Approach to Fulminant Invasive Fungal Rhinosinusitis in the Immunocompromised Host. Archives Otolaryngology Head Neck Surgery 1998;124:1-7.

O’Malley BW Jr., Li D, Duan L., Buckner, A., Pardoll DM. Limitations of IL-2 Gene Therapy for Oral Cancer. The Laryngoscope 1999:109(3):389-95.

Rocco J, Li D, Liggett B, Duan L, Saunders JK, Sidransky D, O’Malley BW, Jr., p16 Adenovirus-Mediated Gene Therapy for Human Head and Neck Squamous Cell Cancer. Clinical Cancer Research 1998;4:1697-1704.

Flint PW, Shiotani A, O'Malley BW, Jr., (Co-corresponding author) IGF-1 Gene Transfer into Denervated Rat Laryngeal Muscles. Archives of Otolaryngology HNS, 1999;125(3):274-9.

Shiotani A, O'Malley BW,Jr., (Co-corresponding author), Flint PW. Reinnervation of Motor Endplates after IGF-1 Gene Transfer into the Paralyzed Larynx. Human Gene Therapy 1998;9:2039-2047.

Simon C, Nemechek AJ, Boyd D, O'Malley BW, Jr., Goepfert H, Flaitz CM, Hicks MJ. An Orthotopic Floor-of-Mouth Cancer Model Allows Quantification of Tumor Invasion. The Laryngoscope 1998;108(11Pt1):1686-91.

Shiotani A, O'Malley BW Jr., Coleman ME, Flint PW. Human insulinlike growth factor 1 gene transfer into paralyzed rat larynx: single vs. multiple injections. Archives of Otolaryngology Head Neck Surgery 1999;125(5):555-60.

Li D., Henley C., O'Malley, B.W., Jr., Otoacoustic Emissions and Auditory Pathway Function in the hyt/hyt Congenital Hypothyroid Mouse. Hearing Research , 138:65-72, 1999.

Li D, Jiang W, Ralston R, O'Malley BW Jr., Combination Surgery and Non-viral IL-2 Gene Therapy for Head and Neck Cancer. Clinical Cancer Research 1999;5:1551-1556.

Li D, Duan L, Freimuth P, O’Malley BW, Jr., Variability of Adenovirus Receptor Density Influences Gene Transfer Efficiency and Therapeutic Response in Head and Neck Cancer. Clinical Cancer Research 1999;4:4175-4181.

Gillespie MB, O'Malley BW Jr., An Algorithmic Approach to the Diagnosis and Management of Invasive Fungal Rhinosinusitis in the Immunocompromised Patient. Otolaryngologic Clinics of North America. 2000;33(2):323-334.

Gillespie MB, Huchton DM, O'Malley BW Jr., The Role of Middle Turbinate Biopsy in the Diagnosis of Fulminant Invasive Fungal Rhinosinusitis. The Laryngoscope 2000 Nov;110(11):1832-6.

O’Malley BW Jr ., Couch ME. Gene Therapy Principles and Strategies for Head and Neck Cancer. Adv Otorhinolaryngology 2000;56:279-88.

H. Staecker, B.W. O'Malley Jr, H. Eisenberg, B. Yoder. Use of the LandmarX ä Surgical Navigation System in Lateral Skull Base and Temporal Bone Surgery. Skull Base Surgery, 2001: 11(No.4);245-255.

Li D, Zeiders JW, Liu S, Guo M, Xu Y, Bishop JS, O'Malley BW Jr., Combination nonviral cytokine gene therapy for head and neck cancer. The Laryngoscope. 2001;111(5):815-2.

Khurana D, Martin EA, Kasperbauer JL, O'Malley BW Jr., Salomao DR, Chen L, Strome SE. Characterization of spontaneously arising murine squamous cell carcinoma (SCCVII) as a prerequisite for head and neck cancer immunotherapy. Head Neck 2001 Oct.23(10):899-906.

Staecker H, Li D, O'Malley BW Jr., Van De Water TR. Gene Expression in the Mammalian Cochlea: A study of multiple vector systems. Acta Otolaryngologica, 2001:121(2):157-63.

Li D, Shugert E, Guo M, Bishop J, O’Malley BW Jr., Combination Non-Viral Interleukin 2 and Interleukin 12 Gene Therapy for Head and Neck Squamous Cell Carcinoma. Archives of Otolaryngology Head Neck Surgery 2001 Nov:127(11):1319-1324.

Day K, Li D, Duan L, O'Malley BW Jr., Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer. The Laryngoscope. 2001 May;111(5):801-6.

Monitto CL, Berkowitz D, Lee KM, Pin S, Li D, Breslow M, O'Malley BW Jr., Schiller, M. Differential gene expression in a murine model of cancer cachexia. Am J Physiol Endocrinol Metab, 2001:281(2): E289-97.

Constance L. Monitto, Dan Berkowitz, Kyoung Min Lee, Sokhon Pin, Daqing Li, Michael Breslow, O’Malley, Bert W. Jr., Martin Schiller. Differential Gene Expression in a Murine Model of Cancer Cachexia. Am J Physiol 2001;28:E289-97

Wolf JS, Malekzadeh S, Berry JA, O'Malley BW Jr., Informed Consent in Functional Endoscopic Sinus Surgery. The Laryngoscope 2002 May;112(5):774-778.

Li D, Day KV, Liu S, Guo M, Sreedharan SP, O’Malley BW Jr.,: The Role of Adenovirus-Mediated Retinoblastoma 94 in the Treatment of Head and Neck Cancer. Cancer Research 2002 August 15;62(16):4637-4644.

Li D, Ronson D, Liu S, Guo M, Bishop J, Van Echo D, Bert W. O’Malley, Jr.,: Interleukin 2 Gene Transfer Prevents NKG2D Suppression and Enhances Anti-tumor Efficacy in Combination with Cisplatin for Head and Neck Squamous Cell Cancer. Cancer Research 2002 July 15;62(14):4023-4028.

Couch MC, Saunders JK, O’Malley BW Jr., Jafee E, Pardoll DM. Genetically engineered tumor cell vaccine in a head and neck cancer model. The Laryngoscope, 2003 March 113(3):552-6.

Bray D, Yu SZ, Koprowski H, Rhee J, Kumar S, Pericle F, Suntharalingam M, Van Echo DA, Li D, O'Malley BW Jr., Combination non-viral interleukin-2 gene therapy and external beam radiation therapy for head and neck cancer. Archives of Otolaryngol Head Neck, 2003 June;129(6)618-22.

Berry J, O'Malley BW Jr., Humphries S, Staecker H. Making Image-Guidance Work: Understanding Control of Accuracy. Annals of Otol Rhinol Laryngol, 2003;112:689-692.

Dasgupta S, Tripathi P, Bhattacharya-Chatterjee M, O’Malley B Jr., Chatterjee S. Recombinant Vaccinia Virus Expressng IL-2 Generates Effective Anti-tumor Responses in an Orthotopic Murine Model of Head and Neck Carcinoma. Molecular Therapy, Vol. 8, No. 2, August 2003, 238-246

Rhee JG, Li D, Guo M, O'Malley BW Jr., Suntharalingam M. Combination radiation and adenovirus mediated p16 (INK4A) gene therapy in a murine model for head and neck cancer. ORL J Otorhinolaryngol 2003 June;65(3);144-154.

O’Malley BW Jr ., Li D., Carney J., Rhee J., Suntharalingam M. Molecular Disruption Of The MRN(95) Complex Induces Radiation Sensitivity in Head And Neck Cancer. The Laryngoscope, 2003 Sep;113(9)1588-94.

Couch MC, Saunders JK, O’Malley BW Jr., Pardoll DM, Jafee E. Spatial Distribution of Tumor Vaccine Improves Efficacy. Laryngoscope 2003 Aug;113(8):1401-5.

Wolf J, Li D, Taylor R, O’Malley BW Jr., Lactoferrin inhibits growth of malignant tumors of the head and neck. ORL J Otorhinolaryngol, 2003

O’Malley BW Jr., Rodrigues M., Tomargo R. Split Calvarial Bone Grafts and Extended Pericranial Flap Reconstruction of Anterior Cranial Base Defects [accepted, Otolaryngol Head Neck Surg, in press 2004]

Flint PW, Nakagawa H, Shiotani A, Coleman ME, and O’Malley BW Jr., Effects of insulin-like growth factor-1 gene transfer on Myosin heavy chains in denervated rat laryngeal muscle.
Laryngoscope. 2004 Feb;114(2):368-71.

Megeed Z, Haider M, Li D, O'Malley BW Jr., Cappello J, Ghandehari H. In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy. J Control Release. 2004 Feb 10;94(2-3):433-45.

Bray DA, Li D, Yu S-Z, Van Echo DA, Sreedharan S, O’Malley. BW Jr., Combination Adenovirus-mediated Retinoblastoma 94 Gene Therapy and Cisplatin for Head and Neck Squamous Cell Carcinoma [submitted, Cancer Research 2004].

Varadhachary A, Wolf J, Petrak K, O’Malley BW Jr., Spadaro M, Curcio C, Forni G, Pericle F. Oral Lactoferrin Inhibits Growth of Established Tumors and Potentiates Conventional Chemotherapy. International Journal of Cancer, 2004 Sep 1; 111(3): 398-403.

O'Malley BW, Jr., Combination Non-viral IL-2 Gene Immunotherapy for Head and Neck Cancer: From Bench Top to Bedside. Triolgical Society Thesis, Laryngoscope, 2005

Varadhachary A, Wolf J, Petrak K, O’Malley BW Jr., Spadaro M, Curcio C, Forni G, Pericle F. Oral Lactoferrin Inhibits Growth of Established Tumors and Potentiates Conventional Chemotherapy. International Journal of Cancer , 2004 Sep 1; 111(3): 398-403.

Wolf JS, Chiu AG, Palmer JN, O’Malley BW Jr.,Schofield K, Taylor RJ. Informed consent in endoscopic sinus surgery: the patient perspective. Laryngoscope . 2005 Mar;115(3):492-4

O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O’Malley BW Jr., Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene . 2005 Feb 10 ;24 (7):1244-51.

Hockstein NG, Nolan PJ, O’Malley BW Jr., Woo JY. Robotic Microlaryngeal Surgery: A technical feasibility study using the daVinci ® surgical robot and an airway mannequin. Laryngoscope, 2005 May; 115(5):780-5.

Taylor RJ, Chiu AG, Palmer JN, Schofield K, O’Malley BW Jr., Wolf JS. Informed consent in endoscopic sinus surgery: the patient perspective. Laryngoscope . 2005 May;115(5):826-31

Hockstein NG, Nolan PJ, O’Malley BW Jr., Woo JY. Robot-assisted Microlaryngeal Surgery: Results of robotic cadaver dissections. Laryngoscope, 2005; June ;115:1003 -1008.

Weinstein GS, O’Malley BW Jr.,( equal first author) , Hockstein NG. Transoral Robotic Surgery (TORS): Supraglottic Laryngectomy in a Canine Model; Laryngoscope, 2005; July ;115 (7):1315-9.

Hockstein NG, Weinstein GS, O’Malley BW Jr.,(all three equal first authors) , Maintenance of Hemostasis in Transoral Robotic Surgery (TORS); ORL J Otorhinolaryngol Relat Spec . 2005

Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr., Chatterjee SK . Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer. J Immunol . 2005 Oct 15 ;175 (8):5541-50.

Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr., Chatterjee SK . Recombinant vaccinia virus expressing interleukin-2 invokes anti-tumor cellular immunity in an orthotopic murine model of head neck squamous cell carcinoma. Mol Ther . 2006 Jan ;13 (1):183-93. Epub 2005 Aug 24.

Hockstein NG, O'Malley BW Jr. (equal first author), Weinstein GS (equal first author) . Assessment of intraoperative safety in transoral robotic surgery. Laryngoscope. 2006 Feb ;116 (2):165-8.

O'Malley BW Jr., Weinstein GS (equal first author), Hockstein NG. T ransoral Robotic Surgery (TORS): Glottic Microsurgery in a Canine Model. J Voice . 2006 Feb 9.

Guyot JP, O 'Malley BW Jr. (Review -Editorial) Tinnitus: between research and clinical application. ORL J Otorhinolaryngol Relat Spec. 2006 ;68 (1):5. Epub 2006 Mar 3.

Li D, Bray DA , ,Yu S-Z, Van Echo DA, Sreedharan S, O'Malley BW Jr. Combination Adenovirus-mediated Retinoblastoma 94 Gene Therapy and Cisplatin for Head and Neck Squamous Cell Carcinoma [submitted 2006].

Newman J, O'Malley BW Jr., Chalian A, and Brown M. Microvascular Reconstruction of Cranial Base Defects: An Evaluation of Complication and Survival Rates to Justify the Use of This Repair. Arch Otolaryngol Head Neck Surg . 2006 ;132:381 -384.

O'Malley BW Jr., Weinstein GS (equal first author), Snyder W, Hockstein NG. Trans Oral Robotic Surgery (TORS) for Base of Tongue Neoplasms. Laryngoscope (accepted and in press 2006).