Hometown
Abington, PA

College
Harvard University, BA Biology, 1989

Medical School
University of Pennsylvania, MD, 1994

Residency Program
Johns Hopkins, Otolaryngology 1997-2000

Fellowship: Location
Hospital of University of Pennsylvania

Fellowship: Area of Concentration
Head and Neck Surgery

Board Certified
Otolaryngology, 2002

Year Appointed to Penn Faculty
2002

Other Faculty Appointments
Adjunct Assistant Professor
Department of Microbiology
Staff Surgeon, VA Hospital

Areas of Expertise
Head and Neck Surgery
Cancer Immunotherapy

Current Research Interests
Basic science research on immunotherapy for head and neck cancer

Positions Held in Major Societies (Past & Present)
Member:
    American Academy of Otolaryngology-Head and Neck Surgery
    American Association Of Cancer Research
    American Head and Neck Society

Research Grants
"Cancer Immunotherapy for HPV+, HLA-A2 Tumors." Percy Memorial Research Award, American Academy of Otolaryngology, 2003-2004
"Cancer Immunotherapy for Head and Neck Tumors." National Institutes of Health Mentored Clinical Scientist Award (K08), 2002-2007
"The Role of p16ß in Head and Neck Cancer." American Society for Head and Neck Surgery, 1997-1998

Honors & Awards
Percy Memorial Research Award, American Academy of Otolaryngology, 2003

Selected Publications
Agrawal N, Sewell DA, Griswold ME, Frank SM, Hessel TW, Eisele DW. Hypothermia during head and neck surgery.
Laryngoscope. 2003 Aug;113(8):1278-82.

Arap W, Knudsen E, Sewell DA, Sidransky D, Wang JY, Huang HJ, Cavenee WK. Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway.
Oncogene. 1997 Oct 23;15(17):2013-20.

Liggett WH Jr, Sewell DA, Rocco J, Ahrendt SA, Koch W, Sidransky D.
p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro.
Cancer Res. 1996 Sep 15;56(18):4119-23.

O'Malley BW Jr, Sewell DA, Li D, Kosai K, Chen SH, Woo SL, Duan L. The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer.
Mol Endocrinol. 1997 Jun;11(6):667-73.

Poje CP, Sewell DA, Saunders JC.  The effects of exposure to intense sound on the DC endocochlear potential in the chick.
Hear Res. 1995 Feb;82(2):197-204.

Sewell DA, Douven D, Pan ZK, Rodriguez A, Paterson Y. Regression of HPV-positive tumors treated with a new Listeria monocytogenes vaccine.
Arch Otolaryngol Head Neck Surg. 2004 Jan;130(1):92-7.

Sewell DA, Li D, Duan L, Westra WH, O'Malley BW Jr. Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Arch Otolaryngol Head Neck Surg. 1997 Dec;123(12):1298-302.

Sewell DA, Li D, Duan L, Schwartz MR, O'Malley BW Jr. Optimizing suicide gene therapy for head and neck cancer.
Laryngoscope. 1997 Nov;107(11 Pt 1):1490-5.

Shah SI, Yip L, Greenberg B, Califano JA, Chow J, Eisenberger CF, Lee DJ, Sewell DA, Reed AL, Lango M, Jen J, Koch WM, Sidransky D.  Two distinct regions of loss on chromosome arm 4q in primary head and neck squamous cell carcinoma.
Arch Otolaryngol Head Neck Surg. 2000 Sep;126(9):1073-6.

Sewell D. "Supracricoid Partial Laryngectomy with Cricohyoidopexy." Operative Techniques in Otolaryngology -Head and Neck Surgery. March, 2003.

Sewell DA, Lai S, Weber R. "Non-melanoma Skin Cancer of the Head and Neck" in Meyers, E. (Ed.) Cancer of the Head and Neck, 2003.

Agrawal N, Sewell DA, Griswold ME, Frank SM, Hessel, TW, Eisele DW. "Hypothermia During Head and Neck Surgery." Laryngoscope 113: 1278-82, 2003.

Shah SI, Yip L, Greenberg B, Califano JA, Chow J, Eisenberger CF, Lee DJ, Sewell DA, et al. "Two Distinct Regions of Loss on Chromosomal Arm 4q in Primary Head and Neck Squamous Cell Carcinoma." Archives of Otolaryngology - Head and Neck Surgery 126: 1073-1076, 2000.