UNIVERSITY OF PENNSYLVANIA - SCHOOL OF MEDICINE

Lawrence Dougherty, Ph.D.



Education:
1977-80      B.S. Stockton State College (Physics)
1988-91      M.S.E. University of Pennsylvania (Bioengineering)
1992-96      Ph.D. University of Pennsylvania (Bioengineering)


Faculty Appointments:
1997 - 2003      Research Assistant Professor of Radiology
                         University of Pennsylvania School of Medicine
2003 -              Research Associate Professor of Radiology
                         University of Pennsylvania School of Medicine


  1. Mezrich RS, Axel L, Dougherty L, Kressel HY. "Strip Scan: A Method for Faster MR Imaging." RadioGraphics 5:833-845, 1986.
  2. Axel L, Dougherty L. "Chemical-Shift Selective Magnetic Resonance Imaging of Multiple Line Spectra by Selective Saturation." J. Mag. Res. 66:194-196, 1986.
  3. Carvlin MJ, Arger PH, Kundel HL, Axel L, Dougherty L, Kassab E, Moore B. "Acute Tubular Necrosis: The Use of Gadolimium-DTPA and fast MRI to Evaluate Renal Function in the Rabbit." J. Comp Asst. Tomogr. 11:488-495, 1987.
  4. Carvlin MJ, Arger PH, Kundel HL, Axel L, Dougherty L, Kassab E, Moore B. "Use of Gd-DTPA and Fast Gradient Echo and Spin-echo MR Imaging to Demonstrate Renal Function in the Rabbit." Radiology 170(3Pt1):705-711, 1989.
  5. Axel L, Dougherty L. "MR Imaging of Motion with Spatial Modulation of Magnetization." Radiology l7l:84l-845, 1989.
  6. Axel L, Dougherty L. "Improved Method of Spatial Modulation of Magnetization (SPAMM) for MRI of heart wall motion." Radiology l72:349-350, 1989.
  7. Axel L, Herman GT, Roberts DA, Dougherty L. "Linogram Reconstruction for Magnetic Resonance Imaging (MRI)." IEEE Trans Med Imaging. 9(4):447-449, 1990.
  8. Young AA, Axel L, Dougherty L, Bogen DK, Parenteau CS. "Validation of MRI Tagging to Estimate Material Deformation." Radiology 188:101-108, 1993.
  9. Hatabu H, Gefter WB, Axel L, Palevsky HI, Cope C, Reichek N, Dougherty L, Listerud J, Kressel HY. "MR Imaging with Spatial Modulation of Magnetization in the Evaluation of Chronic Central Pulmonary Thromboemboli." Radiology 190:791-796, 1994.
  10. Yousem DM, Schnall MD, Dougherty L, Weinstein GS, Hayden RE. "Magentization Transfer Imaging of the Heart and Neck." AJNR 15(6):1117-21, 1994.
  11. Young AA, Kraitchman DL, Dougherty L, Axel L. "Tracking and and Finite Element Modeling of Stripe Deformation in Magnetic Resonance Imaging." IEEE-TMI 14(3):413-421, 1995.
  12. Holland GA, Dougherty L, Carpenter JP, Golden MA, Gilfeather M, Slossman F, Schnall MD, Axel L. "Breath-hold Ultra-fast Three-dimensional Gadolinium-enhanced MR Angiography of the Aorta and the Renal and Other Visceral Abdominal Arteries." AJR 166:971-981, 1996.
  13. Kraitchman DL, Young AA, Bloomgarden DC, Fayad ZA, Dougherty L, Ferrari VA, Boston RC, Axel L. "Integrated MRI assessment of regional function and perfusion in canine myocardial infarction." Mag Res Med 40:311-326, 1998.
  14. Yuan Q, Dougherty L, Margulies SS. "In Vivo Human Cervical Spinal Cord Deformation and Displacement in Flexion." SPINE 23(15):1677-1683, 1998.
  15. Pusca SV, Pilla JJ, Blom AS, Patel HJ, Ferrari VA, Dougherty L, Yuan Q, Axel L, Acker MA: "Determination of global function and regional mechanics of dynamic cardiomyoplasty using magnetic resonance imaging", ASAIO Journal 44:M491-495 1998.
  16. Dougherty L, Pilla, JJ, Blom AS, Pusca SV, Acker MA. "3D Multiphase MR Tagged Imaging of Canine Cardiomyoplasty." IEEE Bioeng Proc Northeast Conf, 83-84, 1999.
  17. Roberts DA. Gefter WB. Hirsch JA. Rizi RR. Dougherty L. Lenkinski RE. Leigh JS Jr. Schnall MD. "Pulmonary perfusion: respiratory-triggered three-dimensional MR imaging with arterial spin tagging--preliminary results in healthy volunteers." Radiology. 212(3):890-895, 1999.
  18. Dougherty L, Asmuth JC, Blom AS, Kumar R, Axel L. "Validation of an Optical Flow Method for Tag Displacement Estimation." IEEE-TMI 18(4): 359-363, 1999.
  19. Yuan Q, Axel L, Hernandez EH, Dougherty L, Pilla JJ, Scott CH, Ferrari VA, Blom AS. Cardiac-respiratory gating method for magnetic resonance imaging of the heart. Mag. Res. Med, 43: 314-318, 2000.
  20. Song HK, Dougherty L. "K-Space Weighted Image Contrast (KWIC) for Contrast Manipulation in Projection Reconstruction MRI." Mag. Res. Med., 44(6), 825-832, 2000.
  21. Blom AS. Pilla JJ. Pusca SV. Patel HJ. Dougherty L. Yuan Q. Ferrari VA. Axel L. Acker MA. "Dynamic cardiomyoplasty decreases myocardial workload as assessed by tissue tagged MRI." ASAIO Journal, 46(5):556-562, 2000
  22. Dougherty L, Connick TJ, Mizsei G. "Cardiac Imaging at 4 Tesla." Mag. Res. Med., 45(1):176-178, 2001.
  23. Uematsu H, Dougherty L, Takahashi M, Ohno Y, Nakatsu M, Song HK, Ferrari VA, Gefter WB, Schnall MD, Hatabu H. "Pulmonary MR Angiography with Contrast Agent at 4 Tesla: A Preliminary Result." Mag. Res. Med., 46(5):1028-1030, 2001.
  24. Song HK, Doughetry L, Schnall MD. "Simultaneous Acquisition of Multiple Resolution Images for Dynamic Contrast Enhanced Imaging of the Breast." Mag. Res. Med., 46(3):503-509, 2001.
  25. Montgomery DD, Morrison WB, Schweitzer ME, Weishaupt D, Dougherty L. "Effects of Iodinated Contrast and Field Strength on Gadolinium Enhancement: Implications for Direct MR Arthrography." JMRI, 15(3):334-43, 2002.
  26. Uematsu H, Dougherty L, Takahashi M, Butler NS, Song HK, Ohno Y, Gefter WB, Schnall MD, Hatabu H. "A Direct Comparison of Signal Behavior between 4.0 Tesla and 1.5 Tesla: A Phantom Study." European Journal of Radiology, 45:154-159, 2002.
  27. Dougherty L, Asmuth JC, Gefter WB. "Alignment of CT Lung Volumes Using an Optical Flow Method." Academic Radiology, 10: 249-254, 2003. Uematsu H, Dougherty L, Takahashi M, Ohno Y, Nakatsu M, Schnall MD, Hatabu H. "Abdominal Imaging at 4 Tesla MR System: A Preliminary Result." European Journal of Radiology, 47:161-163, 2003.
  28. Moate PJ, Dougherty L, Schnall MD, Landis RJ, Boston RC. "A Modified Logistic Model to Describe Gadolinium Kinetics in Breast Tumors." Magnetic Resonance Imaging, 22:467-473, 2004.
  29. Uematsu H, Takahashi M, Dougherty L, Hatabu H. High field body MR imaging; Preliminary experiences. Clin Imaging. 28(3):159-62, 2004.
  30. Song HK, Dougherty L. "Dynamic MRI with Projection Reconstruction and KWIC Processing for Simultaneous High Spatial and Temporal Resolutions." Magn. Reson. Med., 52:815-824, 2004.
  31. Brennick MJ, Pickup S, Dougherty L, Cater JR, Kuna ST. "Pharyngeal airway wall mechanics using tagged magnetic resonance imaging during medial hypoglossal nerve stimulation in rats." J Physiol 561(2):597-610, 2004.
  32. Dougherty L, Torigian DA, Affuso JD, Asmuth JC, Gefter WB. "Use of an Optical Flow Method for the Analysis of Serial CT Lung Images." Academic Radiology, 13(1): 14-23, 2006.


Research Publications, non-peer reviewed:

1. Dougherty L, Chen QC, Asmuth JC. "Strain Analysis of Tagged MR Lung Images." Views Radiology. 4(3):38-39, 2002.

Recent Abtracts
  1. Dougherty L, Connick TJ, Mizsei G. "Cardiac Imaging at 4 Tesla." Proc. ISMRM 8th Scientific Meeting and Exhibition, p1623, Denver CO, April 2000.
  2. Dougherty L, Pilla JJ, Blom AS, Pusca SA, Acker MA. "Assessment of Canine Cardiomyoplasty Using Tissue Tagging at 4T." Proc. ISMRM 8th Scientific Meeting and Exhibition, p1614, Denver CO, April 2000.
  3. Dougherty L, Song HK, LaFuse J, Turpin T. "Reconstruction of Projections Using an Opto-Electronic Processor." Proc. ISMRM 8th Scientific Meeting and Exhibition, p269, Denver CO, April 2000.
  4. Dougherty L, Asmuth JC, Giammarco JM, "Automatic Analysis of Tagged MR Images." Proc. ISMRM 8th Scientific Meeting and Exhibition, p1605, Denver CO, April 2000.
  5. Song HK, Dougherty L. "Ultrafast Technique for Correction of Translational and Rotational Motion in Projection Reconstruction MRI: COBALT." Proc. ISMRM 8th Scientific Meeting and Exhibition, p1693, Denver CO, April 2000.
  6. Dougherty L, Song HK, Schnall MD. "Simultaneous Dynamic and Architectural MR Breast Imaging." Proc. ISMRM 9th Scientific Meeting and Exhibition, p564, Glasgow, April 2001.
  7. Dougherty L, Chen QC, Asmuth JC, Madhav P, Mai VM, Napadow VJ. "Strain Analysis of Tagged MR Lung Images." Proc. ISMRM 10th Scientific Meeting and Exhibition, p1993, Honolulu, May 2002.
  8. Pilla JJ, Dougherty L. "First-pass Cardiac Perfusion Using a Novel Projection Reconstruction Imaging Technique." Proc. ISMRM 11th Scientific Meeting and Exhibition, p1744, Toronto, May 2003.
  9. Dougherty L, Nunes LW, Song HK, Runyon J, Schnall MD. "Diagnostic Performance of High-Resolution Back-Projection Imaging of the Breast." ISMRM 11th Scientific Meeting and Exhibition, p606, Toronto, May 2003.
  10. Dougherty L, Isaac, G, Song HK. "Simultaneous Bilateral 3D DCE-MR Breast Imaging with Radial Acquisition". ISMRM 13th Scientific Meeting and Exhibition, p86, Miami Beach, May 2005.


Chapters:

Roberts DA, Dougherty L. Characterization of Blood Flow Dynamics Using MR: Basic Principles and Clinical Applications in "Seminars in Interventional Radiology" (RA Baum Editor), 15(2):223-233, Thieme, NY.



Patents:
  1. Axel L, Dougherty L. Methods of magnetic resonance imaging using spatial modulation of magnetization. Patent # 5,054,489.
  2. Axel L, Dougherty L. System and method for magnetic resonance imaging of 3-dimensional heart-wall motion with spatial modulation of magnetization. Patent # 5,111,820.

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Last Updated:8/14/06