2008

Anumula SS, Magland J, Wehrli SL, Ong H, Song, HK, Wehrli FW. Multi-modality Study of the Compositional and Mechanical Implications of Hypomineralization in a Rabbit Model of Osteomalacia Bone. Bone 42 (2) 405-413; 2008.

Techawiboonwong A, Song HK, Wehrli F. In vivo MRI of submillisecond T2 species with two-dimensional and three-dimensional radial sequences and applications to the measurement of cortical bone water. NMR Biomed 21(1):59-70; 2008.

Wehrli FW, Ladinsky GA, Jones C, Benito M, Magland J, Vasilic B, Popescu AM, Zemel B, Cucchiara AJ, Wright AC, Song HK, Saha PK, Peachey H, Snyder PJ. In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network following menopause and protective effect of estradiol. J Bone Min Res 23(5): 730-740; 2008.

Ong HH, Wright AC, Wehrli SL, Souza A, Schwartz ED, Hwang SN, Wehrli FW. Indirect measurement of regional axon diameter in excised mouse spinal cord with Q-space imaging: Simulation and experimental studies. NeuroImage 40:1619-1632; 2008.

Rajapakse C, Magland J, Wehrli F. Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies. Magn Reson Med 59(5): 1120-1126; 2008.

Liu XS, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, Guo XE. Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations With Anisotropic Elastic Moduli in Human Trabecular Bone. J Bone Min Res 23(2): 223-235; 2008.

Zhang, XH, Liu, XX, Vasilic B, Wehrli FW, Benito M, Rajapakse CS, Snyder PJ, Guo XE. In Vivo μMRI Based Finite Element and Morphological Analyses of Tibial Trabecular Bone in Eugonadal and Hypogonadal Men before and after Testosterone Treatment. J Bone Miner Res 2008; Vol. 23, No. 9: 1426-1434.

Techawiboonwong A, Song HK, Leonard MB, Wehrli FW. In-vivo quantification of cortical bone water by ultra-short echo-time MRI. Radiology 2008; 248: 824-833.

Magland JF, Wehrli FW. Trabecular bone structure analysis in the limited spatial resolution regime of in vivo MRI. Acad Rad 2008; 15(12): 1482-1493.

Wu WC, Wang JJ, Detre JA, Wehrli FW, Mohler E, Ratcliffe SJ, Floyd TF. Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI. Am J Physiol Heart Circ Physiol 2008; 294: H2129-H2136.

Magland JF, Jones CE, Leonard MB, Wehrli FW. Retrospective 3D registration of trabecular bone MR images for longitudinal studies. J Magn Reson Imaging 2008; In Press.

Li CQ, Magland JF, Rajapakse C, Guo XE, Zhang X, Wehrli FW. Implications of resolution and noise for in vivo micro-MRI of trabecular bone. Med Phys 2008; In press.

Magland J, Wald MJ, Wehrli FW. Spin-echo micro-MRI of trabecular bone using improved 3D FLASE. Magn Reson Med 2008; In press.

2007:

Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song HK, Saha PK, Wright AC, Wehrli FW. Trabecular structure quantified with the MRI-based Virtual Bone Biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Min Res 23(1):64-74; 2008. (Published online September 2007.)

Song R, Lin W, Chen Q, Asakura T, Wehrli FW, Song HK. Relationships between MR transverse relaxation parameters R(*) (2), R(2) and R(‘) (2) and hepatic iron content in thalassemic mice at 1.5 T and 3 T. NMR Biomed; 2007. Early View (On-Line).

Wu WC, Fernández-Seara M, Detre JA, Wehrli FW, Wang J. A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling. Magn Reson Med 58(5):1020-7; 2007.

Wehrli FW. Structural and Functional Assessment of Trabecular and Cortical bone by Micro Magnetic Resonance Imaging. J Magn Reson Imaging 25(2):390-409; 2007.

Wright AC, Bataille H, Ong HH, Wehrli SL, Song HK, and Wehrli FW. Construction and calibration of a 50 T/m z-gradient coil for quantitative diffusion microimaging. Journal of Magn Reson. J Magn Reson 186:17-25; 2007.

Lei T and Wehrli FW. Magnetic Resonance (MR) image analysis – A statistical approach. Int J Image Graphics 7(1):119-142; 2007.

Hopper TAJ, Wehrli FW, Saha PK, Andre JB, Wright AC, Sanchez CP, Leonard MB. Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. J Comp Assist Tomogr 31:320-328; 2007.

Wald M, Vasilic B, Saha PK, Wehrli, FW. Spatial autocorrelation and mean intercept length analysis of trabecular bone anisotropy applied to in vivo magnetic resonance imaging. Med Phys 34(3):1110-1120; 2007.

Saha PK, Das B, Wehrli FW. An object class-uncertainty induced adaptive force and its application to a new hybrid snake. Pattern Recognition 40:2656-2671; 2007.

Techawiboonwong A, Song HK, Wehrli F. In vivo MRI of submillisecond T2 species with two-dimensional and three-dimensional radial sequences and applications to the measurement of cortical bone water. NMR Biomed 2007; in press.

Lin W, Ladinsky GA, Wehrli FW, Song HK. Image metric-based correction (autofocusing) of motion artifacts in high-resolution trabecular bone imaging. J Magn Reson Imaging 26:191-197; 2007.

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2006:

Anumula SS, Magland J, Wehrli SL, Zhang H, Ong H, Song HK, Wehrli FW. Measurement of Phosphorus Content in Normal and Osteomalacic Rabbit Bone by Solid-State 3D Radial Imaging. MRM 56(5):946-952; 2006.

Epstein CL, Magland J. A novel technique for imaging with inhomogeneous fields. Journal of Magn Reson. 183(2):183-192; 2006.

Fernandez-Seara MA, Techawiboonwong A, Detre JA, Wehrli FW. MR Susceptometry for Measuring Global Brain Oxygen Extraction. Magn Reson Med 55:967–973; 2006.

Jones CE, Wolf RL, Detre JA, Das B, Saha PK, Wang J, Zhang Y, Song HK, Wright AC, Mohler III EM, Rairman, RM, Zager EL, Velaquez OC, Golden MA, Carpenter JP, Wehrli FW. Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. NMR in Biomedicine,
vol 19, pp 1-11, 2006.

Lin W, Song HK. Improved optimization strategies for autofocusing motion compensation in MRI via the analysis of image metric maps. Magn Reson Imaging. 24(6):751-60; 2006.

Magland J, Vasilic B, Wehrli FW. Fast Low-Angle Dual Spin-Echo (FLADE): A New Robust Pulse Sequence for Structural Imaging of Trabecular Bone.Magn Reson Medicine 55:465-471; 2006.

Magland J, Wehrli FW. General algorithm for automated off-center MRI. Magn Reson Med. 56(1):230-233; 2006.

Takahashi M, Saha PK, Wehrli FW. Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy. J Bone Min Metab 24:467-475; 2006.

Hopper T, Vasilic B, Pope JM, Jones CE, Epstein CL, Song HK, Wehrli FW. Experimental and computational analysis of the effects of slice distortion from a metallic sphere in an MRI phantom. Magn. Reson. Imaging, 24(8):1077-1085; 2006.

Wehrli FW, Song HK, Saha PK, Wright AC. Quantitative MRI for the assessment of bone structure and function. NMR Biomed 19:731-764; 2006.

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2005:

Anumula, S.S., Song, H.K., Wright, A.C, and Wehrli, F.W. High-Resolution Black-Blood MRI of the carotid vessel wall using phased-array coils at 1.5 and 3 Tesla.Acad. Rad. 12:1521-1526; 2005.

Benito, M., Vasilic, B., Wehrli, F.W., Bunker, B., Wald, M., Gomberg, B., Wright, A.C., Zemel, B., Cucchiara, A., Snyder, P.J. Effect of testosterone replacement on bone architecture in hypogonadal men.Journal of Bone and Mineral Research 20:1785; 2005.

Bouchard, L.S., Wehrli, F.W., Chin, C.L., Warren, W.S. Structural anisotropy and internal magnetic fields in trabecular bone: Coupling solution and solid dipolar interactions. J Magn Reson 176: 27-36; 2005.

Gomberg, B.R., Saha, P.K., Wehrli, F.W. Method for cortical bone structural analysis from magnetic resonance images. Acad. Rad.12:1320-32, 2005.

Lin, W., Wehrli, F.W., Song, H.K. Correcting bulk in-plane motion artifacts in MRI using the point spread function. IEEE Transactions on Medical Imaging . 24(9): 1170-76, 2005.

Magland, J. and Epstein, C.L. Practical pulse synthesis via the discrete inverse scattering transform. Journal of Magnetic Resonance. 2005; 172: 63-78.

Ong H, Chin CL, Wehrli SL, Tang X, Wehrli FW. A New Approach For Simultaneous Measurement of ADC and T2 from Echoes Generated via Multiple Coherence Transfer Pathways. Journal of Magnetic Resonance, 173 (2005) 153-159

Techawiboonwong, A., Song, H.K., Magland, J., Saha, PK, Wehrli, F.W. Implications of pulse sequence in structural imaging of trabecular bone. Journal of Magnetic Resonance Imaging 22:647-656; 2005.

Wehrli F.W., Fernandez-Seara, M. Nuclear magnetic resonance studies of bone water, Annals of Biomedical Engineering 33: 79-86, 2005.

Wolf, R.L., Wehrli, S.L., Popescu, A.M., Woo, J.H., Song, H.K., Wright, A.C., Mohler, E.R., Harding, J.D., Zager, E.L., Fairman, R.M., Golden, M.A., Velaquez, O.C., Carpenter, J.P., Wehrli, F.W. Mineral volume and morphology in carotid plaque specimens using high-resolution MRI and CT. Arterioschlerosis, Thrombosis, and Vascular Biology 25(8): 1729-35, 2005.

Zhang, Y., Song, H.K., Techawiboonwong, A., Wehrli, F.W. Spatially-confined arterial spin-labeling with FAIR. Journal of Magnetic Resonance Imaging 22: 119-124; 2005.

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2004:

Chin C.-L., Wehrli F.W., Fan Y, Hwang S.N., Schwartz E.D., Nissanov J., Hackney, D.B. Assessment of axonal fiber tract architecture in rat spinal cord by localized NMR q-space imaging: simulations and experimental studies. Magnetic Resonance in Medicineicine, 52: 733-40, 2004.

Fernandez-Seara M, Wehrli, SL, Takahashi M, Wehrli, FW. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Mineral Res 19: 289-296; 2004.

Gomberg BR, Wehrli FW, Vasilic B, Weening RH, Saha PK, Song HK, and Wright AC. Reproducibility and error sources of μ -MRI-based trabecular bone structural parameters of the distal radius and tibia.Bone 35 (2004) 266–276

Magland, J. and Epstein, C.L. Exact half pulse synthesis via the inverse scattering transform. Journal of Magnetic Resonance. 2004; 171 305-313.

Saha PK, Wehrli FW. A Robust Method for measuring trabecular bone orientation anisotropy at in vivo resolution using tensor scale. Pattern Recognition 37(9): 1935-1944; 2004.

Song HK, Dougherty L. Dynamic MRI With Projection Reconstruction and KWIC Processing for Simultaneous High Spatial and Temporal Resolution Magnetic Resonance in Medicine 52:815–824 (2004)

Takahashi, M., Wehrli, F.W., Micro MRI of trabecular bone. Clinical Calcium . 14: 47-54, 2004. (Japanese)

Tang XP,. Chin, CL, Bouchard LS, Warren WS, Wehrli FW. Observing Bragg-like diffraction via multiple coupled nuclear spins. Physics Letters A326: 114-125; 2004.

Uematsu H, Popescu A, Zhang G, Wright AC, Wehrli SL, Takahashi M, Wehrli FW, Selzer ME, Hackney DB. Magnetization Transfer Micro-MR Imaging of Live Excised Lamprey Spinal Cord: Characterization and Immunohistochemical Correlation. Americal Journal of Neuroradiology 25:1816–1820, November/December 2004.

Vasilic B, Song HK, Wehrli FW. Coherence-Induced Artifacts in Large-Flip-Angle Steady-State Spin-Echo Imaging Magnetic Resonance in Medicine 52:346–353 (2004)

Wehrli, F.W. On the 2003 Nobel Prize in medicine or physiology awarded to Paul C. Lauterbur and Sir Peter Mansfield. Magnetic Resonance in Medicineicine 52: 1-3, 2004.

Wehrli FW, Leonard MB, Saha PK, Gomberg BR. Quantitative high-resolution MRI reveals structural implications of renal osteodystrophy on trabecular and cortical bone. J Magn Reson Imaging 20: 83-89; 2004.

Zhang Y, Wehrli FW. Reference-scan-free method for automated correction of Nyquist ghost artifacts in echoplanar brain images. Magnetic Resonance in Medicineicine 51:621-624; 2004.

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2003:

Benito M, Gomberg B, Wehrli FW, Weening RH, Zemel B, Wright AC, Song HK, Cucchiara A, Snyder PJ. Deterioration of Trabecular Architecture in Hypogonadal Men The Journal of Clinical Endocrinology & Metabolism 88: 1497-502; 2003.

Chin C-L, Tang X, Bouchard LS, Saha PK, Warren WS, Wehrli FW. Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI. . J Magn Reson 165: 309-314; 2003.

Chin, C-L, Wehrli FW, Hwang SN, Jaggard DL, Hackney DB, Wehrli SL. Feasibility of probing boundary morphology of structured materials by 2D NMR q-space imaging. . J Magn Reson 160: 20-25; 2003.

Fernandez-Seara M, Wehrli, SL, Wehrli, FW. Multipoint mapping for imaging of semisolid materials, J. Magn Reson 160: 144-150; 2003.

Gomberg BR, Saha PK, Wehrli, FW. Topology-based orientation analysis of trabecular bone networks. Med Phys 30; 158-168; 2003.

Hwang SN, Chin C-L, Wehrli FW, Hackney DB. An image-based finite difference model for simulating restricted diffusion Magnetic Resonance in Medicine 50: 373-382; 2003.

Saha PK, Wehrli FW. Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform, IEEE Transactions on Medical Imaging 23: 53-62; 2004.

Saha PK, Wehrli FW, Gomberg, BR. Fuzzy distance transform: Theory, algorithms and applications. Computer Vision Image Understanding 86: 171-190; 2003.

Wehrli FW, Saha PK, Gomberg, BR, Song HK. Noninvasive assessment of bone architecture by magnetic resonance micro-imaging-based virtual bone biopsy. Proceedings of the IEEE 91: 1520-1542; 2003.

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2002:

Chin CL, Wehrli FW, Hwang SN, Takahashi M, Hackney DB. Bi-exponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture. Magnetic Resonance in Medicine. 2002; 47:455-60.

Fernandez-Seara MA, Wehrli SL, Wehrli FW. Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance. Biophysics Journal. 2002; 82:522-9.

Hwang SN, Wehrli FW. Subvoxel Processing: A Method for reducing partial volume blurring with application to in vivo MR images of trabecular bone. Magnetic Resonance in Medicineicine 2002;47:948-957.

Song HK, Wright AC, Wolf RL, Wehrli FW. Multi-slice double inversion pulse sequence for efficient black-blood MRI. Magnetic Resonance in Medicine. 2002; 46:103-13.

Takahashi M, Hackney DB, Zhang G, Wehrli SL, Wright AC, O'Brien WT, Uematsu H, Wehrli FW, Selzer ME. Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord. Proceedings of the National Academy of Sciences USA 99 (25):16192-16196; 2002.

Takahashi M, Wehrli FW, Hilaire L, Zemel BS, Hwang SN. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proceedings of the National Academy of Sciences USA ;19:19; 2002.

Wehrli FW, Hilaire L, Fernandez-Seara M, Gomberg BR, Song HK, Zemel B, Loh L, Snyder PJ. Quantitative magnetic resonance imaging in the calcaneus and femur of women with varying degrees of osteopenia and vertebral deformity status. J Bone Min Res 2002; 17: 2265-2273.

Wehrli F, Saha P, Gomberg B, Song H, Snyder P, Benito M, Wright A, Weening R. Role of magnetic resonance for assessing structure and function of trabecular bone. Topics in Magnetic Resonance Imaging 13; 335-355; 2002.

Wright AC, Wehrli SL, Zhang G, et al. Visualization of individual axons in excised lamprey spinal cord by magnetic resonance microscopy. Journal of Neuroscience Methods. 2002; 144:9-15 .

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2000-01:

Fernandez-Seara MA, Song HK, Wehrli FW. Trabecular bone volume fraction mapping by low-resolution MRI. Magnetic Resonance in Medicine. 2001;46:103-13.

Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ. Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. Journal of Bone and Mineral Research. 2001;16:1520-31.

Fernandez-Seara MA, Wehrli FW. Postprocessing technique to correct for background gradients in image-based R*(2) measurements. Magnetic Resonance in Medicine. 2000;44:358-66.

Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW. Topological analysis of trabecular bone MR images. IEEE Transactions on Medical Imaging. 2000;19:166-74.

Hilaire L, Wehrli FW, Song HK. High-speed spectroscopic imaging for cancellous bone marrow R2* mapping and lipid quantification. Magnetic Resonance Imaging. 2000;18:777-786.

Saha PK, Gomberg BR, Wehrli FW. Three-dimensional digital topological characterization of cancellous bone architecture. International Journal of Imaging Systems and Technology. 2000;11:81-90.

Takahashi M, Wehrli FW, Hwang SN, Wehrli SL. Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. Magnetic Resonance Imaging. 2000;18:33-9.

Wehrli FW, Hopkins JA, Hwang SN, Song HK, Snyder PJ, Haddad JG. Cross-sectional study of osteopenia by quantitative magnetic resonance and bone densitometry. Radiology, 217: 527 -538; 2000.

Wright AC, Song HK, Wehrli FW. In vivo MR micro imaging with conventional radiofrequency coils cooled to 77 degrees K. Magnetic Resonance in Medicine. 2000;43:163-9.

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1998-99:

Hwang SN, Wehrli FW. Estimating voxel volume fractions of trabecular bone on the basis of magnetic resonance images acquired in vivo. International Journal of Imaging Systems and Technology. 1999;10:186-198.

Hwang SN, Wehrli FW. Experimental evaluation of a surface charge method for computing the induced magnetic field in trabecular bone. Journal of Magnetic Resonance. 1999;139:35-45.

Song HK, Wehrli FW. In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis.Magnetic Resonance in Medicine. 1999;41:947-953.

Takahashi, M, Wehrli, FW, Wehrli, SL, Hwang, SN, Lundy, MW, Hartke, J, Borah, B. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative 3D NMR microscopy. Journal of Bone and Mineral Research. 1999;14:680-689.

Wright, AC, Song, HK, Wehrli, FW. In vivo MR micro imaging with conventional radiofrequency coils cooled to 77K. Magnetic Resonance in Medicine 43: 169-69; 1999

Song HK, Wehrli FW. Variable TE gradient and spin echo sequences for in vivo MR microscopy of short T2 species. Magnetic Resonance in Medicine. 1998;39:251-258.

Wehrli, FW, Hwang, SN, Ma, J, Song, HK, Ford, JC, Haddad, JGCancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing[published erratum appears in Radiology 1998 Jun; 207(3):833]. Radiology 206:347-57; 1998.

Wehrli, FW, Ma, J, Hopkins, JA, Song, HK. Measurement of R2' in the presence of multiple spectral components using reference spectrum deconvolution. Journal of Magnetic Resonance 131:61-68; 1998.

Wehrli, FW, Hwang, SN, Song, HK.New architectural parameters derived from micro-MRI for the prediction of trabecular bone strengthTechnology and Health Care 6:307-20; 1998.

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1995-97:

Hopkins, JA, Wehrli, FW. Magnetic susceptibility measurement of insoluble solids by NMR: magnetic susceptibility of bone Magnetic Resonance in Medicine 37:494-500; 1997.

Hwang SN, Wehrli FW, Williams JL. Probability-based structural parameters from 3D NMR images as predictors of trabecular bone strength. Medical Physics. 1997;24:1255-1261.

Ma J, Wehrli FW, Song HK, Hwang SN. A single-scan imaging technique for quantitation of the relative contents of fat and water protons and their transverse relaxation times. Journal of Magnetic Resonance. 1997;125:92-101.

Song HK, Wehrli FW, Ma J. In vivo MR microscopy of the human skin. Magnetic Resonance in Medicine. 1997;37:185-191.

Song, HK, Wehrli, FW, Ma, J. Field strength and angle dependence of trabecular bone marrow transverse relaxation in the calcaneus Journal of Magnetic Resonance Imaging 7:382-388; 1997.

Chung, HW, Hwang, SN, Yeung, HN, Wehrli, FW. Mapping of the magnetic-field distribution in cancellous bone.Journal of Magnetic Resonance, Series B. 113(2):172-6; 1996.

Ma J, Wehrli FW, Song HK. Fast 3D large-angle spin-echo imaging (3D FLASE). Magnetic Resonance in Medicine. 1996;35:903-910.

Ma J, Wehrli FW. Method for image-based measurement of the reversible and irreversible contribution to the transverse relaxation rate. Journal of Magnetic Resonance, Series B. 1996;111:61-69.

Hwang SN, Wehrli FW. The calculation of the susceptibility-induced magnetic field from 3d nmr images with applications to trabecular bone. Journal of Magnetic Resonance, Series B. 1995;109:126-145.

Chung, HW, Wehrli, FW, Williams, JL, Kugelmass, SD, Wehrli, SL. Quantitative analysis of trabecular microstructure by 400 MHz nuclear magnetic resonance imaging. Journal of Bone and Mineral Research 10(5) :803-811; 1995.

Chung, HW, Wehrli, FW, Williams, JL, Wehrli, SL. Three-dimensional nuclear magnetic resonance microimaging of trabecular bone. Journal of Bone and Mineral Research 10(10):1452-146; 1995.

Wehrli, FW, Ford, JC, Haddad, JG. Osteoporosis: clinical assessment with quantitative magnetic resonance imaging in diagnosis. Radiology 196:631-641;1995

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