Computational Breast Imaging Group - Members

Brad M. Keller, PhD

Brad M. Keller, PhD

Postdoctoral Researcher

Contact Information:

University of Pennsylvania Perelman School of Medicine
Department of Radiology
3600 Market Street, Suite 360
Philadelphia PA 19104-2643
Office: 215-615-0826

Education and Training:

  • Postdoctoral researcher, 2010-present (University of Pennsylvania)
  • Clinical Research Certificate, Feb 2013 (University of Pennsylvania)
  • Ph.D. Biomedical Engineering, Jan 2011 (Cornell University)
  • M.S. Biomedical Engineering, May 2009 (Cornell University)
  • B.S. Biomedical Engineering, May 2005 (University of Miami)

Brad M. Keller, Ph.D, is a post-doctoral fellow in the Computational Breast Imaging Group (CBIG) in the Center for Biomedical Image Computing and Analytics (CBICA) at the Perelman School of Medicine at the University of Pennsylvania. Dr. Keller is a multidisciplinary scientist focusing on breast cancer risk assessment, with experience in biomedical quantitative image analysis techniques, human physiology, disease processes, biostatistics and software development. Dr. Keller received a Research Trainee Award by the Radiological Society of North America in 2011 for his work investigating radiographic-genotypic associations of breast density, a major known risk factor for breast cancer. Prior to joining Penn, he received his B.S. in Biomedical Engineering (cum laude) from the University of Miami and his M.S and Ph.D. degrees in Biomedical Engineering from Cornell University.

Current research

Dr. Keller's overall research strategy focuses on the development and analyses of clinically applicable image-derived biomarkers of tissue pathophysiology from radiological and histopathological data in order to improve assessment of cancer-risk and response-to-treatment at the individual patient-level. Current research lines include:

  • Identification of radiographic biomarkers of breast tissue histology and microenvironment
  • Development of quantitative, open-source software to measure breast density and other image-derived biomarkers of breast cancer risk
  • Development of automated algorithms for the characterization of digital pathology data for improved throughput and reproducibility
  • Validation and epidemiological studies supporting the clinical utility of automated software developed by our group

Distinctions and awards

  • National Institutes of Health, LRP Award, Clinical Research, 2012-2014
  • Radiological Society of North America (RSNA) Trainee Research Award Fellow, 2011
  • U.S. Food and Drug Administration Medical Device Fellow, 2009
  • Sage Fellowship, Cornell University, 2008-2009
  • National Action Council for Minorities in Engineering (NACME) Sloan PhD Fellowship, Cornell University, 2005-2008
  • Florida-Georgia Alliance for Minority Participation (FGAMP) Scholarship, 2001-2005

Journal publications

  • McAllister, D. A., Ahmed, F.S., Austin, J.H., Henschke, C.I., Keller, B.M., et al., "Emphysema Predicts Hospitalisation and Incident Airflow Obstruction among Older Smokers: A Prospective Cohort Study," PloS one, Vol. 9(4), e93221, April 2014. PMID: 24699215
  • Keller, B.M., Nathan, D.L., Gavenonis, S.C., Chen, J., Conant, E.F., and Kontos D., "Reader Variability in Breast Density Estimation from Full-Field Digital Mammograms: The effect of Image Post-processing on Relative and Absolute Measures," Academic Radiology, Vol. 20(5), pp. 560-568, May 2013. PMID: 23465381
  • Daye, D., Keller, B.M., Conant, E.F., Chen, J., Schnall, M.D., Maidment, A.D.A., Kontos, D., "Mammographic Parenchymal Patterns as an Imaging Marker of Endogenous Hormonal Exposure: a Preliminary Study in a High-Risk Population," Academic Radiology, Vol. 20(5), pp.635-646, May 2013. PMID: 23570938 (Received: Memorial Award, Association of University Radiologists)
  • Keller, B.M., Nathan, D.L., Wang, Y., Zheng, Y., Gee, J.C., Conant, E.F., and Kontos D., "Estimation of Breast Percent Density in Raw and Processed Full Field Digital Mammography Images via Adaptive Fuzzy C-means Clustering and Support Vector Machine Segmentation," Medical Physics, Vol. 39(8), pp. 4903-4917, Aug 2012. PMID: 22894417
  • Keller, B.M., Chen, W., and Gavrielides, M.A., "Quantitative Assessment and Classification of Tissue-based Biomarker Expression Using Color Content Analysis," Archives of Pathology and Laboratory Medicine, Vol. 136(5), pp. 539-550, May 2012. PMID: 22540303
  • Keller, B.M., Reeves, A.P., Henschke, C.I., and Yankelevitz, D.F., "Multivariate compensation of quantitative pulmonary emphysema metric variation from low-dose, whole-lung CT scans," American Journal of Roentgenology, Vol. 197(3), pp. W495-502, Sep 2011. PMID: 21862778
  • Keller, B., Nathan, D., Wang, Y., Zheng, Y., Gee, J., Conant, E., and Kontos D., "Adaptive Multi-cluster Fuzzy C-means Segmentation of Breast Parenchymal Tissue in Digital Mammography," Medical Image Computing and Computer Assisted Intervention (MICCAI), Lecture Notes in Computer Science (LNCS). G. Fichtinger, A. Martel, and T. Peters (Eds.) (eds.). Springer-Verlag Berlin Heidelberg, Part III, LNCS 6893: pp. 562569, Sept 2011, PMID: 22003744
  • Reeves, A.P., Biancardi, A.M., Yankelevitz, D., Fotin, S., Keller, B.M., Jirapatnakul, A., Lee, J., "A Public Image Database to Support Research in Computer Aided Diagnosis," 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009, pp. 37153718, Sept 2009, PMID: 19965010
  • Barr, R.G., Mesia-Vela, S., Austin, J.H., Basner, R.C., Keller, B.M., Reeves A.P., Shimbo, D. and Stevenson, L. "Impaired Flow-mediated Dilation is Associated with Low Pulmonary Function and Emphysema in Ex-smokers: the Emphysema and Cancer Action Project (EMCAP) Study," American Journal of Respiratory and Critical Care Medicine, Vol. 176(12), pp.1200-1207, Dec 2007, PMID: 17761614

Selected Conference Presentations

  • Keller, B.M., Chen, J., Conant, E.F. and Kontos, D. "Breast density and parenchymal texture measures as potential risk factors for estrogen-receptor positive breast cancer," in SPIE Medical Imaging 2014: Computer Aided Diagnosis, S. Aylward and L.M. Hadjiiski, eds., Feb. 2014
  • Keller, B.M., Chen, J., Wang, Y., Zheng, Y., Gee, J.C., Conant, E.F., and Kontos, D., "The Complementary Roles of Breast Density and Parenchymal Texture in Breast Cancer Risk Assessment: A Case-Control Study with Digital Mammography," RSNA Scientific Assembly and Annual Meeting 2013, Nov 2013.
  • Keller, B.M., Nathan, D.L., McDaniel, L.D., Bristol, N., Wang, Y., Zheng, Y., Gee, J.C., Conant, E.F., and Kontos D., "Multi-Vendor Validation Of A Fully-Automated Breast Density Estimation Method Applicable To Both Raw And Processed Digital Mammograms," 6th International Workshop on Breast Densitometry and Breast Cancer Risk Assessment, Jun 2013.
  • Keller, B.M., Daye, D., Chen, J., Jing, H., Conant, E.F., an Kontos, D., "The Role of Volumetric and Area Density Measures in Breast Cancer Risk Assessment," RSNA Scientific Assembly and Annual Meeting 2012, Nov 2012.
  • Keller, B.M., Nathan, D.L., Conant, E.F., and Kontos, D. "Model-based estimation of breast percent density in raw and processed full-field digital mammography images from image-acquisition physics and patient-image characteristics," In SPIE Medical Imaging 2012: Physics of Medical Imaging, N. Pelc and R.M. Nishikawa and B.R. Whiting, eds., Feb 2012.
  • Keller, B.M., Conant, E.F., Chen, J., Domcheck, S., Handorf, E., Jones, M., Boghossian, L., Armstrong, K., and Kontos, D. "Identification of Genetic Determinants for Fibroglandular Breast Tissue Volume: Associations between Image-based and Genomic Biomarkers of Breast Cancer Risk," RSNA Scientific Assembly and Annual Meeting 2011, Nov 2011. (Awarded RSNA Trainee Research Prize, Fellow-Category)
  • Keller, B.M., Nathan, D.L., Gavenonis, S.C., Bakic, P.R., Maidment, A.D.A., Conant, E.F., and Kontos, D. "Challenges in Imaged-based Assessment of Breast Density: The Lack of Ground Truth," RSNA Scientific Assembly and Annual Meeting 2011, Nov 2011.