brenda hoffman, M.D.
Associate Professor of Medicine
Medical Director, Acute Dialysis Program
Presbyterian Medical Center
Business Address:
Presbyterian Medical Center
240 Medical Office Building
51 N. 39th Street
Philadelphia, PA 19104
Phone: 215-662-8730
Fax: 215-243-4686
Email: brenda.hoffman@uphs.upenn.edu
Education:
Undergraduate: Franklin and Marshall College, Lancaster, PA
Medical: The Hospital of the University of Pennsylvania, Philadelphia, PA
Residency: Graduate Hospital, Philadelphia, PA
Fellowship: The Hospital of the University of Pennsylvania, Philadelphia, PA
Board Certification: Internal Medicine and Nephrology
Clinical Interests:
Selected References::
Han, D.C., M. Isono, B.B. Hoffman, F.N. Ziyadeh. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: Mediation by autocrine activation of TGF-b. Journal of American Society of Nephrology 10:1891-1899, 1999.
Isono, M. A. Mogyorosi, D.C. Han, B.B. Hoffman, F.N. Ziyadeh. Stimulation of TGF-b type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney. American Journal of Physiology 278: F830-F838, 2000.
Han, D.C., B.B. Hoffman, J. Guo, F.N. Ziyadeh: Therapy with antisense TGF-b1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. American Journal of Physiology 278:F628-F634, 2000.
Ziyadeh, F.N., B.B. Hoffman, D.C. Han, M.C. Iglesias-De La Cruz, S.W. Hong, M. Isono, S. Chen, T.A. McGowan, K. Sharma. Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice. Proceedings of the National Academy of Sciences 97(14): 8015-20, 2000.
MacRae Dell, K., B.B Hoffman., M.B Leonard,. F.N Ziyadeh, S.L. Schulman. Increased urinary transforming growth factor beta-1 (TGF-b1) excretion in children with posterior urethral valves. Urology 56(2):311-4, 2000.
Chen, S., B.B. Hoffman, B. Jim, J.S. Lee, J.B. Kopp, F.N. Ziyadeh. Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose. Kidney International 65:1191-1204, 2004.