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Clinical Office - Patients
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.
Suite 1-300S
Philadelphia, PA 19104
Phone: 215-662-2638
Fax: 215-349-5703

Research Faculty Office:
Room 305 CRB
415 Curie Boulevard
Philadelphia, PA 19104
Phone: 215-573-1830
Fax: 215-898-0189

Administration Office:
Hospital of the University
of Pennsylvania
Renal-Electrolyte &
Hypertension Division
One Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-662-7934
Fax: 215-615-0349

brenda hoffman, M.D.

Associate Professor of Medicine
Medical Director, Acute Dialysis Program
Presbyterian Medical Center

Business Address:

Presbyterian Medical Center
240 Medical Office Building
51 N. 39th Street
Philadelphia, PA 19104

Phone: 215-662-8730
Fax: 215-243-4686


Undergraduate: Franklin and Marshall College, Lancaster, PA

Medical: The Hospital of the University of Pennsylvania, Philadelphia, PA

Residency: Graduate Hospital, Philadelphia, PA

Fellowship: The Hospital of the University of Pennsylvania, Philadelphia, PA

Board Certification: Internal Medicine and Nephrology

Clinical Interests:

Selected References::

Han, D.C., M. Isono, B.B. Hoffman, F.N. Ziyadeh.  High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts:  Mediation by autocrine activation of TGF-b.  Journal of American Society of Nephrology 10:1891-1899, 1999.


 Isono, M. A. Mogyorosi, D.C. Han, B.B. Hoffman, F.N. Ziyadeh.  Stimulation of                  TGF-b type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney. American Journal of Physiology 278: F830-F838, 2000.


Han, D.C., B.B. Hoffman, J. Guo, F.N. Ziyadeh: Therapy with antisense TGF-b1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. American Journal of Physiology  278:F628-F634, 2000.


Ziyadeh, F.N., B.B. Hoffman, D.C. Han, M.C. Iglesias-De La Cruz, S.W. Hong, M. Isono, S. Chen, T.A. McGowan, K. Sharma.   Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice.  Proceedings of the National Academy of Sciences  97(14): 8015-20, 2000.


MacRae Dell, K.,  B.B Hoffman., M.B Leonard,. F.N Ziyadeh, S.L. Schulman.  Increased urinary transforming growth factor beta-1 (TGF-b1) excretion in children with posterior urethral valves.  Urology 56(2):311-4, 2000.


Chen, S., B.B. Hoffman, B. Jim, J.S. Lee, J.B. Kopp, F.N. Ziyadeh.  Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose.  Kidney International 65:1191-1204, 2004.



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