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Research Faculty Office:
Renal Division

Suite 305 CRB
415 Curie Boulevard Philadelphia, PA 19104
Phone: (215) 573-1830
Fax: (215) 898-0189

Administration Office:
Hospital of the University
of Pennsylvania
Renal-Electrolyte &
Hypertension Division
One Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Phone: (215) 662-7934
Fax: (215) 615-0349

Research

Lawrence B. Holzman, MD

Lawrence Holzman, MD
Dr. Holzman is an established laboratory investigator, well recognized for his investigations of podocyte biology, where he has contributed importantly to our understanding of the mechanisms that govern podocyte cytoskeletal architecture. Recently, he has played an organizing role in establishing an NIH sponsor national consortium for the study of glomerular disease.

 
Jeffrey Berns, M.D., F.A.C.P.

Jeffrey Berns, M.D., F.A.C.P.
Dr. Berns' research interests have primarily focused on the management of anemia in patients with chronic kidney disease and in hemodialysis patients. Another particular area of interest is drug dosing in patients with reduced kidney function.

 
Russ P. Carstens, M.D.

Russ P. Carstens, M.D.
Study of the molecular mechanisms of alternative splicing. Identification of global changes in splicing during the epithelial-mesenchymal transition (EMT).

A number of potential projects to investigate the targets and functions of the ESRPs can be discussed.  In addition to further characterizing the molecular mechanisms of ESRP function, we are generating mice with conditional knockout of the ESRPs in order to further investigate their functions in vivo.  Among several areas of interest, we plan to investigate the role of the ESRPs in renal organogenesis in which we anticipate they regulate splicing events that are required for the mesenchymal to epithelial transition (MET) in metanephric mesenchyme during kidney development.

 
Debbie L. Cohen-Stein, M.D.

Debbie L. Cohen-Stein, M.D.
Research interests are in hypertension with an emphasis on alternative methods of treating hypertension and in the field of pheochromocytoma and adrenal hypertension.

 
Raphael M. Cohen, M.D.

Raphael M. Cohen, M.D.
Mineral and bone disease in CKD, anemia in CKD, and dialysis access.

   

Laura M. Dember, MD
Dr. Dember conducts patient oriented and translational research in end-stage renal disease, chronic kidney disease, and systemic amyloidosis.        

Her research programs focus on elucidation of mechanisms underlying hemodialysis vascular access failure and development of targeted treatment approaches, interventions to improve outcomes in chronic kidney disease and maintenance hemodialysis, and novel treatment approaches for the systemic amyloidoses.

 
Harold Feldman, M.D.

Harold Feldman, M.D.
Dr. Feldman's major research interests address the epidemiology of kidney diseases with a particular focus on the management of kidney disease from the stage of chronic kidney dysfunction to end-stage renal disease. He leads CCEB-based researchers and several national research groups addressing various manifestations and treatment of kidney disease.

 
Stanley Goldfarb, M.D.

Stanley Goldfarb, M.D.
My research interests have primarily focused on the management of fluid and electrolyte, metabolism and diabetic nephropathy.

 
Mary Leonard, M.D.

Mary Leonard, M.D.
Dr. Leonard has established a multidisciplinary research program in clinical bone disease in children and adults. Her research program is focused on (1) the accurate assessment and diagnosis of osteoporosis in children with chronic disease, (2) the detrimental effects of glucocorticoid therapy, muscle deficits and inflammation on bone development in varied pediatric disorders, (3) the assessment of the unique effects of kidney disease, dialysis and transplantation on skeletal structure in children and adults using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical functioning and cardiovascular disease in adults with chronic kidney disease, and (5) the evaluation of biomechanical interventions as potential anabolic bone therapies in patients with chronic disease.

 
Joshua H. Lipschutz, M.D.

Joshua H. Lipschutz, M.D.
Cystogenesis, tubulogensis, and kidney development.

Cystogenesis and tubulogenesis are important for many complex biological processes such as organ development, regeneration following acute kidney injury (AKI), and diseases such as Autosomal Dominant Polycystic Kidney Disease (ADPKD). This lab has three basic experimental goals: first, to find novel genes involved in cyst and tubule formation using techniques such as DNA microarray analysis; second, to determine the molecular mechanism by which these candidate genes act using both in vitro and in vivo studies, such as the creation of transgenic and knockout mice; and, finally, to utilize this knowledge to identify treatment strategies for ADPKD and to accelerate recovery following AKI.

 
Jonathan Maltzman, M.D., Ph.D.

Jonathan Maltzman, M.D., Ph.D.
Memory T cells may be generated in response to infection, previous exposure to alloantigens, and lymphopenia. Once generated, memory T cells persist for the lifetime of the host. The Maltzman lab is interested in the intracellular signaling pathways that are involved in the generation, maintenance and activation of these cells.

 
Peter Reese, M.D.

Peter Reese, M.D.
Dr. Reese's primary research focus is the development of effective strategies to increase access to kidney and liver transplantation. He uses tools from epidemiology, biostatistics, medical ethics and health services research to describe disparities in transplantation and methods to overcome them. The widening gap between the number of patients wait-listed for transplants and the limited number of organs available makes this research focus important and timely.

 
 
Raymond Townsend, M.D.

Raymond Townsend, M.D.
Raymond R. Townsend, MD, is a Professor of Medicine, an Associate Director of the federally funded Clinical & Smilow Center for Translational Research (SCTR) at the University of Pennsylvania, and the Director of the Penn Hypertension program. He is currently a Principal Investigator in a 7-center U01 grant (DK-060984) to evaluate the role of demographic, humoral and genetic factors in the progression of kidney disease and the development and progression of cardiovascular disease in patients with chronic kidney disease. He is the P.I. of an R01 grant evaluating the specific role of pulse wave velocity in the renal and cardiovascular consequences of chronic kidney disease (DK-067390).

   

Katalin Susztak, MD, PhD
Dr. Susztak's reserach examines cellular and molecular mechanisms that contribute to progressive kidney tissue loss in diabetic nephropathy and other chronic kidney diseases.

   
Alan G. Wasserstein, M.D.

Alan G. Wasserstein, M.D.
Faculty Affairs, Nephrolithiasis, History of Medicine

   


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