Sylvia E. Rosas, M.D., M.S.C.E.
Assistant Professor of Medicine
Business Address:
University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-615-3446
Fax: 215-615-3447
Email: sylvia.rosas@uphs.upenn.edu
Education:
Medical: Colegio Mayor de Nuestra Senora del Rosario, Bogota, Columbia
Postgraduate: University of Pennsylvania, Philadelphia, PA
Residency: Michael Reese Hospital, University of Illinois, Chicago, IL
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA
Board Certification: Internal Medicine and Nephrology
Biography:
Dr. Rosas's primary research focus is on cardiovascular disease in patients with chronic kidney disease including the role of novel risk factors in the development and progression of atherosclerosis. Oxidative stress, inflammation, mineral and lipid metabolism are of particular interest. She studies the impact of vascular calcification in morbidity and mortality in chronic kidney disease. She is currently performing a randomized control trial to assess the differential effect of different types of activated vitamin D in progression of coronary calcification.
She is an ancillary Principal Investigator to the Chronic Renal Insufficiency Cohort (CRIC, a multicenter study of 3600 participants with CKD sponsored by NIH. She is evaluating how novel and traditional cardiovascular risk factors affect atherosclerosis measured by carotid intima-media thickness and plaque.
Selected References:
DeLoach S, Joffe MM, Mai X, Goral S, Rosas SE: Aortic Calcification Predicts Cardiovascular Events in Renal Transplantation Nephrology, Dialysis and Transplantation 24(4): 1314-9, April 2009
SS DeLoach, LJ Appel, J Chen, MM Joffe, CA Gadegbeku, ER Mohler III, A Parsa, K Perumal, MA Rafey, SP Steigerwalt, V Teal, RR Townsend and SE Rosas: AORTIC PULSE PRESSURE IS ASSOCIATED WITH CAROTID IMT IN CHRONIC KIDNEY DISEASE: REPORT FROM CHRONIC RENAL INSUFFICIENCY COHORT. American Journal of Hypertension 2009.
Kamoun M, Holmes JH, Israni AJ, Kearns JD, Teal V, Yang W, Rosas SE, Joffe M, Li H, and Feldman HI: HLA-A amino acid polymorphism and delayed kidney allograft function. Proc Natl Acad Sci U S A. 105(48): 18883-8, Dec 2008
Adeseun GA, Joffe M, Rosas SE: Coronary Artery Calcification and Metabolic Syndrome in Renal Transplant Recipients. Transplantation 86(5): 728-32, Sept 2008.
Rosas SE, Joffe MM, Wolfe M, Brayman K, Rader DJ: Effects of renal replacement therapy on plasma lipoprotein (A) levels. American Journal of Nephrology 28: 361-365, Jan 2008.
Hernandez C, Herrera I, Lage OG, Pereira AN, Rosas SE: Strategies for improving the Office of Minority Health. Ethnicity and Disease 18(3), Summer 2008.
Kamoun M, Israni A, Joffe M, Hoy T, Kearns J, Mange K, Feldman D, Goodman N, Rosas SE: Assessment of differences in HLA-A, B and DRB1 allele mismatches among African American and non-African American recipients of deceased kidney transplants. Transplant Proceedings 39: 55-63, 2007.
Tan A., Wilensky R. L., Matthai W, Schankel K, Munoz M, and Rosas SE: Electron-Beam Computerized Tomography (EBCT) correlates with Coronary Angiogram in Chronic Kidney Disease Patients. Am J of Nephrology 27: 247-252, 2007.
Israni AK, Li N, Sidhwani S, Rosas SE, Joffe M, Rebbeck T, Feldman HI: Association of hypertension genotypes and decline in renal function after kidney transplantation. Transplantation 27(84): 1240-1247, 2007.
Schankel K, Robinson J, Bloom RD, Guerra C, Rader D, Joffe M, Rosas SE: Determinants of Coronary Artery Calcification (CAC) Progression in Renal Transplant Recipients. American Journal of Transplantation 7(9): 2158-64, 2007.