Ambulatory Clinical Programs

The Renal-Electrolyte and Hypertension Division offers diagnostic evaluation and clinical management for patients with acute or chronic kidney diseases, renal failure, hypertension, diabetic nephropathy, glomerulonephritis, nephrotic syndrome, interstitial nephritis, electrolyte and acid-based disturbances, hematuria, proteinuria, and kidney stones.

Out-Patient Nephrology Practice

Lawrence B. Holzman, MD

Associate Chief:
Jeffrey S. Berns, MD

The Hospital of the University of Pennsylvania
Perelman Center for Advanced Medicine
3400 Civic Center Boulevard, 1-300 South
Philadelphia, PA 19104
Phone: 215-662-2638


The HUP Out-Patient Nephrology Practice is based in the Perelman Center for Advanced Medicine. Our faculty and fellows evaluate and treat patients with diverse kidney diseases (see below) from a very wide geographic area. We provide consultations and second opinions for referring primary care physicians, nephrologists, and other physicians. Patients cared for as children at Children's Hospital of Philadelphia (CHOP) are often seen here when they reach adulthood. We offer comprehensive and continuing care for patients in our general geographic area and those from greater distances who wish to have ongoing care here at Penn. We also work closely with referring physicians, including local nephrologists, to coordinate specialty care close to home as appropriate. As a referral center our physicians are happy to perform kidney biopsies and their interpretation for patients needing this procedure, and work closely with referring physicians to provide appropriate treatment based on biopsy findings. We are also happy to assist in the care of patients who have had kidney biopsies performed prior to coming to HUP.

We see patients who require dialysis at four locations in Philadelphia's University City area and one at Penn Medicine Radnor. Our physicians are expert with all dialysis treatment types, including in-center hemodialysis, home hemodialysis, in-center nocturnal hemodialysis, and peritoneal dialysis. We provide comprehensive educational programs for patients with chronic kidney disease.

Diseases Treated

  • Hematuria
  • Proteinuria
  • Chronic Kidney Disease
  • Diabetic Nephropathy
  • Hypertension
  • Lupus
  • Recurrent Urinary Tract Infections
  • Renovascular Disease
  • Renal Tubular Abnormalities
  • Fluid and Electrolyte Disorders
  • Glomerulonephritis
  • Nephrotic Syndrome
  • Systemic Lupus Erythematosus
  • Vasculitis
  • Interstitial Nephritis

Participating Physicians

  • All clinical Nephrology faculty and fellows

Lupus Program


  • Lawrence B. Holzman, MD
    Chief, Renal Electrolyte and Hypertension Division

  • Staffan W. Schulz, MD

The Hospital of the University of pennsylvania
Perelman Center for Advanced Medicine
3400 Civic Center Boulevard, 1-300 South
Phone: 215-662-2638


The PennMedicine Lupus Program provides specialized, multidisciplinary care for patients with lupus systemic lupus erythermatosus (SLE), systemic vasculitis, and similar disorders that affect multiple organs, including the kidneys. The program delivers coordinated care faciliated by a multidisciplinary team Penn nephrologists, rheumatologists and other subspecialists.

Complex Hypertension Program

Penn Center for the Assessment and Treatment of Complex Hypertension

Debbie Cohen, MD

Clinic Location:
Perelman Center for Advanced Medicine, 1-300 South

Clinic Contact Information:

  • Complex Hypertension:
  • Neuroendocrine Tumor Center/Adrenal Hypertension:
    215-349-5562 (Bonnie Bennett, RN)
  • Ambulatory BP Monitoring:

Diseases Treated

  • Essential hypertension
  • Renovascular hypertension
  • Adrenal causes of hypertension
  • Hyperaldosteronism
  • Pheocromocytoma/Paragangliomas
  • White Coat Hypertension
  • Masked Hypertension
  • Fibromuscular dysplasia

Clinical Services

The complex hypertension program provides comprehensive care of patients with severe hypertension. We see 60-80 new patients and 400-600 return patients in our clinics annually. We have an outstanding reputation and a very wide referral base across the Delaware Valley from internists, cardiologists, endocrinologists and other subspecialists.

Complete diagnostic work up of hypertension includes biochemical evaluation and imaging if appropriate. Ambulatory BP monitoring is available to assist with diagnosis of white coat hypertension and masked hypertension. Treatment regimens are tailored to the individual patient. Our large neuroendocrine program deals specifically with patients with pheochromocytomas and paragangliomas. This program provides genetic counseling and testing and a multidisciplinary approach to treatment with involvement of surgery, endocrinology, oncology, medical genetics, and radiation oncology.


We have a large research program in hypertension. Patients may participate in active clinical studies if they are interested. Our ongoing research includes the following studies:

  • Alternative therapies for hypertension - NIH funded study assessing the antihypertensive effects of yoga
  • NIH-sponsored study looking at different systolic blood pressure goals
  • Symplicity 3 Study - multi-center study of sympathetic renal nerve ablation for severe refractory hypertension
  • Non-invasive measures of arterial stiffness and their relation to blood pressure

Participating Physicians

  • Debbie Cohen, MD, Director of Clinical Hypertension Programs
  • Raymond Townsend, MD, Director of Hypertension Research
  • Melissa Bleicher, MD
  • Yonghong Huan, MD
  • Alan Wasserstein, MD

Kidney Stone Clinic

Alan G. Wasserstein, MD

Locations & Contacts

The Hospital of the University of Pennsylvania
Perelman Center for Advanced Medicine, Suite 1-300S
Philadelphia, PA 19104
Phone: 215-662-2638

Penn Medicine at Radnor
250 King of Prussia Road
Radnor, PA 19087
Phone: 610-902-1500


The Stone Evaluation Center has been devoted to metabolic evaluation and prevention of kidney stones since 1978. Over three thousand patients have been evaluated and treated. We follow hundreds of patients and evaluate over one hundred new patients annually, from a referral base that extends beyond the Delaware Valley. Using blood studies and urine chemistry, we analyze the causes of nephrolithiasis in each patient. Then we use diet, lifestyle changes, and medications to prevent or even reverse stone growth or new stone formation.

Although the Stone Center does not perform interventional procedures, we work closely with the Division of Urology at Penn to plan and enhance the care of patients who require endourological stone extraction or lithotripsy. In over 80% of cases, metabolic activity of nephrolithiasis (growth of old stones and appearance of new stones) is reduced.

In many hospitals and health systems, a clinic devoted to prevention of kidney stones does not exist. We are proud to offer this service to our patients and to educate our trainees in this endeavor.

Diseases Treated

  • Calcium, Uric Acid, Infection and Cystine Kidney Stones
  • Hypercalciuria, Hypocitraturia, Hyperoxaluria, and Hyperuricosuria
  • Primary Hyperparathyroidism
  • Renal Tubular Acidosis
  • Sarcoidosis
  • Stone-associated Osteoporosis
  • Primary and Enteric Oxaluria
  • Cystinuria
  • Dent Disease

Participating Physicians

Perelman Center for Advanced Medicine:

  • Alan Wasserstein, MD (Director)
  • Joel Glickman, MD
  • Yonghong Huan, MD
  • Sidney Kobrin, MD

Penn Medicine at Radnor:

  • Joel Glickman, MD
  • Brenda Hoffman, MD
  • Sidney Kobrin, MD

General Ambulatory Renal Practice at Penn Presbyterian Medical Center

Presbyterian Medical Center
51 North 29th Street
Philadelphia, PA 19104
Phone: 215-662-8000

The Penn Presbyterian Medical Center (PPMC) Renal Practice treats patients with diverse renal diseases, such as hematuria, proteinuria, chronic kidney disease, diabetic nephropathy, hypertension, kidney stones, renovascular disease, fluid and electrolyte disorders, glomerulonephritis, and nephrotic syndrome.

Outpatient Dialysis Programs

The Penn Renal-Electrolyte and Hypertension provides care for in center and Home hemodialysis and peritoneal dialysis patients at four dialysis facilities that are owned and operated by Davita, Inc.

The University City facility is one of the few dialysis facilities in the country that offers every option for renal replacement therapy including: Peritoneal dialysis, home short daily hemodialysis, home nocturnal hemodialysis, and on site nocturnal hemodialysis.

  • 42nd and Walnut Street Unit
    Medical Director: Alan Wasserstein, MD
    Phone: 215-662-2638

  • 42nd and Walnut Street Unit
    Home Hemodialysis Program
    Medical Director: Joel Glickman
    Phone: 215-662-2638

  • Penn Presbyterian Medical Center Unit
    Medical Director: Michael Rudnick, MD
    Phone: 215-662-0691

  • Radnor Unit
    Medical Director: Sidney Kobrin, MD
    Phone: 610-254-0070

  • Radnor Unit
    Home Hemodialysis Program

    Medical Director: Joel Glickman, MD
    Phone: 610-254-0070

  • 3701 Market Street Dialysis Unit
    Medical Director: Yonghong Huan, MD
    Phone: 215-662-0691

  • 3020 Market Street
    Suite 103

    Medical Director: Joel Glickman, MD
    Phone: 215-328-2439

Renal Transplant Program

This program provides pretransplant evaluation for living-related and deceased-donor kidney transplants, post-transplant care in both ambulatory and in-patient settings, and consultation for patients with non-renal solid organ transplants with chronic kidney disease. Transplants are performed by surgeons in the Department of Surgery's Transplantation Division and cared for jointly by both groups.

The Penn Renal-Electrolyte and Hypertension partners with the Penn Transplant Institute to provide comprehensive kidney and pancreas transplant-related care. In addition to the Perelman Center for Advance Medicine, some transplant-related services are now available at Penn Medicine Radnor, Penn Medicine Bucks County, and Penn Medicine Cherry Hill.

Kidney and pancreas transplants are performed at the Hospital of the University of Pennsylvania. Penn's Kidney Transplant Program is among the oldest and largest in the United States, and consistently achieves among the highest volumes and best outcomes in the Mid-Atlantic region.

Medical Director of Kidney and Pancreas Transplantation:
Roy Bloom, MD

Kidney/Pancreas Transplant Evaluation Locations

Penn Kidney and Pancreas Transplant Program
Perelman Center for Advanced Medicine
Phone: 215-662-6200

  • 3400 Civic Center Boulevard
    West Pavilion, 2nd Floor
    Philadelphia, PA 19104

  • 3400 Civic Center Boulevard
    South Pavilion, 1st Floor
    Philadelphia, PA 19104

  • Penn Medicine Radnor
    250 Kind of Prussia Road
    Radnor, PA 19087

  • Penn Medicine Bucks County
    777 Township Line Road
    2nd Floor
    Yardley, PA 19067

  • Penn Medicine Cherry Hill
    1400 East Route 70
    Cherry Hill, NJ 08034

  • Penn Medicine Woodbury

1006 Mantua Pike

Woodbury Heights, NJ  08097

Clyde F. Barker Penn Transplant House

For many patients, the good news of a life-saving organ is accompanied by feelings of uncertainty and a whole new set of challenges. With one-third of Penn Transplant Institute patients coming from more than 50 miles away, the Clyde F. Barker Penn Transplant House offers convenient services in a supportive, community setting for a nominal cost.

The Clyde F. Barker Penn Transplant House, named for Penn's world-renowned transplant suregon, was designed and built entirely through the generosity of private donations. It is a sun-filled space built around a central coutryard providing a home-like setting for transplant families and patients.

Philadelphia Veteran's Medical Center

Veterans Administration Hospital
3900 Woodland Avenue
Philadelphia, PA 19104

The Veteran's Administration Hospital is a medical and surgical center, as well as a teaching hospital in Philadelphia servicing veterans with various medical treatments and patient care.

Joshua Lipschutz, MD
Phone: 215-573-1848

Consultation in all aspects of Nephrology and Hypertension

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