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Edward Cantu, III, M.D.
Cardiovascular Surgery

 
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  • Education
  • Memberships
  • Research
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
6 Silverstein Pavilion
Philadelphia, PA 19104
Administrative Assistant: Julianne Davis
Administrative Telephone: 215-615-6582
Administrative Fax: 215-349-5798

Clinical Office:
Perelman Center for Advanced Medicine
Heart & Vascular Center
East Pavilion, 2nd floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-615-6582
Clinical Fax:
215-349-5798

Contact Information (internal use only)

edward.cantu@uphs.upenn.edu

 

Dr.

 
Faculty Appointments
2010 - present

Assistant Professor of Surgery
at HUP, PPMC & PAH
Perelman School of Medicine
Philadelphia, Pennsylvania

 
Hospital and Administrative Appointments
2010 - present Attending Surgeon
Hospital of the University of Pennsylvania Philadelphia, Pennsylvania
 
2010 - present Active Surgeon
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2010 - present Active Surgeon
Pennsylvania Hospital
Philadelphia, Pennsylvania
   
2010 - present

Assistant Professor of  Surgery, Associate Surgical Director of Lung Transplantation
Director of Ex Vivo Lung Perfusion Center
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania

   
2011 - present The Gift of Life Donor Program Medical Advisory and Policy Board member
   
2012 - present International Society of Heart and Lung Transplantation Registry and Database
Working Group
   
2012 - present Surgical Director of Lung Transplantation
Hospital of the University of Pennsylvania
 
Education/Training
1990 - 1994 B.A. Harvard University
Cambridge, Massachusetts (Biology)
 
1994 - 2000 M.D. Columbia University College of Physicians and Surgeons
New York, New York
 
Postgraduate Training and Fellowship Appointments
2000 - 2001 Internship, General and Thoracic Surgery
Duke University Medical Center
Durham, North Carolina
 
2001 - 2002 Junior Assistant Resident
General and Thoracic Surgery
Duke University Medical Center
Durham, North Carolina
 
2002 - 2004 Research Fellow in Thoracic Transplantation
Duke University Medical Center
Durham, North Carolina
 
2004 - 2006 Senior Assistant Resident in General and Thoracic Surgery
Duke University Medical Center
Durham, North Carolina
 
2006 - 2007 Chief Resident in General and Thoracic Surgery
Duke University Medical Center
Durham, North Carolina
 
2007 - 2010 Cardiothoracic Surgery Resident
Duke University Medical Center
Durham, North Carolina
 
Memberships/Societies
 
National/International Societies
1994 - present American Medical Association
 
2002 - present American College of Surgeons
 
2007 - present American Society of Transplant Surgeons
 
2007 - present American College of Chest Physicians
   
 
Research
2007 - 2010   American Society of Transplant Surgeons, “Prospective Registry of Outcomes in Patients Electing Lung Transplantation (PROPEL): A correlative analysis using gene signature array” (Cantu Co-PI)
 
 
 
 
 
 
 
 
Publications
 
Research Publications, Peer Reviewed
  1. O'Hair DP, Cantu E, McGregor C, Jorgensen B, Gerow-Smith R, Galantowicz ME, Schulman LL. Preliminary experience with mycophenolate mofetil used after lung transplantation. J Heart Lung Transplant 1998;17(9):864-8.
  2. Maruyama S, Cantu E, 3rd, Demartino C, Vladutiu A, Caldwell PR, Wang CY, D'Agati V, Godman G, Stern DM, Andres G. Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis. J Am Soc Nephrol 1999;10(10):2102-8.
  3. Maruyama S, Cantu E, 3rd, DeMartino C, Wang CY, Chen J, Al-Mohanna F, Nakeeb SM, D'Agati V, Pernis B, Galili U, Godman G, Stern DM, Andres G. Interaction of baboon anti-alpha-galactosyl antibody with pig tissues. Am J Pathol 1999;155(5):1635-49.
  4. Maruyama S, Cantu E, Pernis B, Galili U, Godman G, Stern DM, Andres G. Alpha-galactosyl antibody redistributes alpha-galactosyl at the surface of pig blood and endothelial cells. Transpl Immunol 1999;7(2):101-6.
  5. Schulman LL, O'Hair DP, Cantu E, McGregor C, Ginsberg ME. Salvage by volume reduction of chronic allograft rejection in emphysema. J Heart Lung Transplant 1999;18(2):107-12.
  6. Biancone L, Cantaluppi V, Segoloni G, Boccellino M, Del Sorbo L, Conaldi PG, Tjoelker LW, Maruyama S, Cantu E, Stern D, Andres G, Camussi G. Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. Transplantation 2000;70(8):1198-205.
  7. Maruyama S, Cantu E, 3rd, Galili U, D'Agati V, Godman G, Stern DM, Andres G. alpha-galactosyl epitopes on glycoproteins of porcine renal extracellular matrix. Kidney Int 2000;57(2):655-63.
  8. Lau CL, Cantu E, 3rd, Gonzalez-Stawinski GV, Holzknecht ZE, Nichols TC, Posther KE, Rayborn CA, Platt JL, Parker W, Davis RD. The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation. Am J Transplant 2003;3(9):1065-75.
  9. Cantu E, 3rd, Appel JZ, 3rd, Hartwig MG, Woreta H, Green C, Messier R, Palmer SM, Davis RD, Jr. J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg 2004;78(4):1142-51; discussion -51.
  10. Cantu E, Davis RD. Lung Transplantation: Timing, Perioperative Considerations and Postoperative Outcome. Advances in Pulmonary Hypertension 2004;3(1):9-18.
  11. Cantu E, Parker W, Platt JL, Duane Davis R. Pulmonary xenotransplantation: rapidly progressing into the unknown. Am J Transplant 2004;4 Suppl 6:25-35.
  12. Hartwig MG, Appel JZ, 3rd, Cantu E, 3rd, Simsir S, Lin SS, Hsieh CC, Walczak R, Palmer SM, Davis RD, Jr. Improved results treating lung allograft failure with venovenous extracorporeal membrane oxygenation. Ann Thorac Surg 2005;80(5):1872-9; discussion 9-80.
  13. Hartwig MG, Patel V, Palmer SM, Cantu E, Appel JZ, Messier RH, Davis RD. Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation. Transplantation 2005;80(3):320-5.
  14. Lukes DJ, Cantu E, Gaca JG, Hallberg E, Karlsson-Parra A, Parker W, Olausson M, Davis RD. Oral feeding with pig peripheral lymphocytes decreases the xenogeneic delayed type hypersensitivity reaction in galactosyltransferase knockout mice. Transplant Proc 2005;37(8):3327-31.
  15. Radeva JI, Reed SD, Kalo Z, Kauf TL, Cantu E, 3rd, Cretin N, Schulman KA. Economic evaluation of everolimus vs. azathioprine at one year after de novo heart transplantation. Clin Transplant 2005;19(1):122-9.
  16. Appel JZ, 3rd, Hartwig MG, Cantu E, 3rd, Palmer SM, Reinsmoen NL, Davis RD. Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies. Transplantation 2006;81(7):1049-57.
  17. Cantu E, Gaca JG, Palestrant D, Baig K, Lukes DJ, Gibson SE, Gonzalez-Stawinski GV, Olausson M, Parker W, Davis RD. Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction. Transplantation 2006;81(8):1157-64.
  18. Appel JZ, 3rd, Lee SM, Hartwig MG, Li B, Hsieh CC, Cantu E, 3rd, Yoon Y, Lin SS, Parker W, Davis RD. Characterization of the innate immune response to chronic aspiration in a novel rodent model. Respir Res 2007;8:87.
  19. Cantu E, Balsara KR, Li B, Lau C, Gibson S, Wyse A, Baig K, Gaca J, Gonzalez-Stawinski GV, Nichols T, Parker W, Davis RD. Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts. Am J Transplant 2007;7(1):66-75.
  20. Hartwig MG, Snyder LD, Appel JZ, 3rd, Cantu E, 3rd, Lin SS, Palmer SM, Davis RD. Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation. J Heart Lung Transplant 2008;27(5):547-53.
  21. de la Fuente SG, Safford SD, Cantu E, Ludwig KA. Spinal abscess presenting as the initial symptom of Crohn's disease. Int J Colorectal Dis 2009;24(5):601-2.
  22. Diamond JM, Meyer NJ, Feng R, Rushefski M,  Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group.Variation in PTX3 is Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine. In press.
Abstracts
  1. O'Hair DP, Cantu E, Schulman LL, McGregor C, Simonelli P, Jellen P, Ginsberg ME. Lung Volume Reduction Surgery following Single Lung Transplantation for Emphysema. ISHLT 1996.
  2. O'Hair DP, Cantu E, Umana JP, McGregor C, Ginsberg ME, Schulman LL, Galantiwicz ME. Lung Transplantation Using Mycophenolate Mofetil. ISHLT 1996.
  3. Cantu E, Maruyama S, Al-Mohanna F, Nakeeb SM, Wang  CY, Godman G, Galili U, Stern DM, Andres G. Lesions Induced in Pig Lungs by Baboon Anti-alpha-Galactosyl Antibody. AHA 1998.
  4. Cantu E, Gaca JG, Lukes DJ , Palestrant D, Baig K, Gonzalez-Stawinski GV, Parker W, Davis RD. Depletion of Porcine Pulmonary Intravascular Macrophages Attenuates Hyperacute Pulmonary Xenograft Dysfunction. IXA 2003.
  5. Cantu E, Gaca JG, Lukes DJ , Palestrant D, Baig K, Gonzalez-Stawinski GV, Parker W, Davis RD. Passenger Pulmonary Macrophages Play a Key Role in the Coagulopathy and Endothelial Activation Associated with Pulmonary Xenograft Dysfunction. IXA 2003.
  6. Cantu E, Gibson S, Wyse A, Lau CL, Gaca JG, Gonzalez-Stawinski GV, Baig K, Nichols T, Parker W, Davis RD. Role of porcine von Willebrand factor in Pulmonary Xenograft Injury. IXA 2003.
  7. Cantu E, Appel JZ, Hartwig MG, Palmer S, Messier R, Davis RD. Early Fundoplication Prevents Chronic Allograft Dysfunction In Patients With Gastroesophageal Reflux Disease (GERD). STS  2003 (J. Maxwell Chamberlain Award).
  8. Lukes DJ, Cantu E, Gaca JG, Hallberg E, Karlsson-Parra A, Parker W, Olausson M, Davis RD.Oral Feeding With Pig Peripheral Lymphocytes (pPBL) Decreases The Xenogeneic DTH Reaction In Galactosyltransferase Knockout Mice. STA 2003.
  9. Appel JZ, Cantu E, Hartwig MG, Reinsmoen NL, Palmer SM and Davis RD. Role of Flow Cytometry to Exclude Unacceptable HLA Antigens in Lung Transplant Recipients with Anti-HLA Antibodies. ISHLT 2004.
  10. Hartwig MG, Cantu E, Appel JZ, Woreta H, Palmer SM and Davis RD. Non- Alloimmune Injury Mediated by Gastroesophageal Reflux Precipitates Alloimmune Injury in Lung Transplant Patients. ISHLT 2004.
  11. Hartwig MG, Kadakia A, Cantu E, Appel JZ, Davis RD, Palmer SM. Non-Specific Bronchial Hyperreactivity After Lung Transplant is not Related to Gastroesophageal Reflux or Predictive of Clinical Outcomes. ATS 2004.
  12. Hartwig MG, Appel JZ, Cantu E, Davis RD. Early reflux monitoring following lung transplantation may underestimate the incidence of gastroesophageal reflux. ATC 2004
  13. Appel JZ, Burgess BO, Herczyk WF, Cantu E, Hartwig MG, Palmer SM, Davis RD, Reinsmoen NL. Perioperative desensitization therapy decreases acute rejection in sensitized lung transplant recipients. ASHI 2004.
  14. Appel JZ, Burnette A, Mohler K, Li B, Hartwig M, Cantu E, Palmer S, Parker W, Reinsmoen N, Davis D. Role of cellular immunity in GERD-associated bronchiolitis obliterans syndrome. ACS 2004.
  15. Cantu E, Gibson S, Wyse A, Lau C, Gaca J, Gonzalez-Stawinskil GV, Baig K, Nichols T, Parker W, Davis RD. Porcine von Willebrand factor antigen deficiency with pulmonary intravascular macrophage depletion abrogates hyperacute pulmonary xenograft dysfunction. ATC 2004.
  16. Bush EL, Appel JZ, Li B, Balsara KR, Hartwig M, Cantu E, Parker W, Davis RD, Lin SS. Chronic aspiration in lung allotransplantation induces a donor-specific hyperimmune state. ISHLT 2007
  17. Bush EL, Balsara KR, Hartwig M, Pbillips-Bute BG, Shaw A, Cantu E, Appel JZ, Davis RD, Welsby IJ, Lin SS. Perioperative predictors of renal failure following off-pump primary double lung transplantation. ISHLT 2007.
  18. Bush EL, Balsara KR, Hartwig MG, Appel JZ, Cantu E, Simsir SA, Parker WR, Palmer SM, Lin SS, Davis RD. Effectiveness of non-primary single lung transplants for patients with COPD and bronchiolitis obliterans syndrome (BOS) following initial lung transplant. ATC 2007.
  19. Balsara KR, Cantu E, Bush EL, Appel JZ, Hartwig MG, Lin SS, Davis RD. Early fundoplication reduces the incidence of chronic allograft drysfunction in patients with gastroesophageal reflux disease. ISHLT 2008.
  20. Shah RJ, Diamond JM, Kawut S, Cantu E, Wickersham N, Ware LB, Christie JD. Plasma RAGE levels measured 24 hours after lung transplantation are associated with bronchiolitis obliterans syndrome (BOS). ISHLT 2012.
  21. Diamond JM, Feng R, Meyer NJ, Shah R, Kawut SM, Lederer DJ, Lee JC, Ahya V, Cantu E, Weinacker A, Bhorade S, Lama VN, Orens JB, Sonett J, Willie KM, Crespo M, Weill D, Kohl B, Arcasoy SM, Shah AS, Shah PD, Demissie E, Reynolds JM, Belperio JA, Wilkes D, Ware LB, Palmer SM, Christie JD. Functional TLR4 polymorphisms are associated with lower risk of primary graft dysfunction (PGD) after lung transplantation. ISHLT 2012.
  22. Cantu E, Erhunmwunsee L, Feng R, Meyer NJ, Diamond JM, Shah RJ, Rao S, Lin SS, Davis RD, Christi JD. Paired donor lung expression suggest key effectors in primary graft dysfunction. ISHLT 2012.
  23. Diamond JM, Meyer NJ, Feng R, Rushefski M,  Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group.Variation in PTX3 is Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine. In press.
  24. Diamond JM, Meyer NJ, Feng R, Rushefski M,  Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group: Variation in PTX3 is Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine In Press.
  25. Diamond Joshua M, Feng Rui, Meyer Nuala, Lederer David, Lee James C, Kawut Steven M, Ahya Vivek, Cantu Edward, Palmer Scott, Weinacker Ann, Bhorade Sangeeta, Lama Vibha, Orens Jonathan B, Sonett Joshua, Wille Keith, Crespo Maria, Weill David, Kohl Benjamin, Deutschman Clifford, Arcasoy Selim, Shah Ashish, Shah Pali D, Demissie Ejigayehu, Reynolds John, Belperio John, Wilkes David, Ware Lorraine, Christie Jason D: PTX3 Polymorphisms Are Associated with Primary Graft Dysfunction after Lung Transplantation. The Journal of Heart and Lung Transplantation 30(4): S23, April 2011 Notes: International Society for Heart and Lung Transplantation 2011
  26. Diamond Joshua M, Lederer David, Kawut Steven M, Lee James C, Cantu Edward, Ahya Vivek, Palmer Scott, Weinacker Ann, Bhorade Sangeeta, Lama Vibha, Orens Jonathan B, Sonett Joshua, Wille Keith, Crespo Maria, Weill David, Kohl Benjamin, Deutschman Clifford, Arcasoy Selim, Shah Ashish, Shah Pali D, Demissie Ejigayehu, Reynolds John, Belperio John, Wilkes David, Ware Lorraine, Christie Jason D: Elevated PTX3 Concentration Is Associated with Primary Graft Dysfunction after Lung Transplantation in Patients with Idiopathic Pulmonary Fibrosis The Journal of Heart and Lung Transplantation 30(4): S23-S24, April 2011 Notes: International Society for Heart and Lung Transplantation 2011
  27. Diamond Joshua M, Feng Rui, Meyer Nuala J, Kawut Steven M, Lee James C, Ahya Vivek, Cantu Edward, Ware Lorraine, Palmer Scott M, Bhorade Sangeeta, Lama Vibha N, Weinacker Ann, Orens Jonathan B, Sonett Joshua, Wille Keith M, Crespo Maria, Weill David, Kohl Benjamin, Deutschman Clifford, Arcasoy Selim M, Shah Ashish S, Shah Pali D, Demissie Ejigayehu, Reynolds John M, Belperio John A, Lederer David J, Christie Jason D: Genetic Variation In Prostaglandin E2 Family Members Is Associated With The Development Of Primary Graft Dysfunction After Lung Transplantation  American Journal of Respiratory and Critical Care Medicine Page: A4014, May 2011 Notes: American Thoracic Society 2011.
  28. Diamond Joshua M, Feng Rui, Meyer Nuala J, Kawut Steven M, Lee James C, Ahya Vivek, Cantu Edward, Ware Lorraine, Palmer Scott M, Bhorade Sangeeta, Lama Vibha N, Weinacker Ann, Orens Jonathan B, Sonett Joshua, Wille Keith M, Crespo Maria, Weill David, Kohl Benjamin, Deutschman Clifford, Arcasoy Selim M, Shah Ashish S, Shah Pali D, Demissie Ejigayehu, Reynolds John M, Belperio John A, Lederer David J, Christie Jason D: Genetic Variation In Prostaglandin E2 Family Members Is Associated With The Development Of Primary Graft Dysfunction After Lung Transplantation. University of Pennsylvania Department of Medicine Research Day June 2011.
  29. Diamond Joshua M, Feng Rui, Meyer Nuala J, Kawut Steven M, Lee James C, Ahya Vivek, Cantu Edward, Ware Lorraine, Palmer Scott M, Bhorade Sangeeta, Lama Vibha N, Weinacker Ann, Orens Jonathan B, Sonett Joshua, Wille Keith M, Crespo Maria, Weill David, Kohl Benjamin, Deutschman Clifford, Arcasoy Selim M, Shah Ashish S, Shah Pali D, Demissie Ejigayehu, Reynolds John M, Belperio John A, Lederer David J, Christie Jason D: Genetic Variation in Prostaglandin E2 Family Members is Associated with the Development of Primary Graft Dysfunction. NHLBI Symposium on Gene Discovery and Clinical Applications for Cardiovascular, Lung, and Blood Diseases  September 2011.
  30. Diamond Joshua M, Feng Rui, Meyer Nuala J, Shah Rupal J, Kawut Steven M, Lederer David J, Lee James C, Ahya Vivek, Cantu Edward, Weinacker Ann, Bhorade Sangeeta, Lama Vibha N, Orens Jonathan B, Sonett Joshua, Wille Keith M, Crespo Maria, Weill David, Kohl Benjamin, Arcasoy Selim M, Shah Ashish S, Shah Pali D, Demissie Ejigayehu, Reynolds John M, Belperio John A, Wilkes David, Ware Lorraine B, Palmer Scott M, Christie Jason D: Functional TLR4 Polymorphisms Are Associated with Lower Risk of Primary Graft Dysfunction (PGD) after Lung Transplantation The Journal of Heart and Lung Transplantation 31(4): S76, April 2012 Notes: International Society of Heart and Lung Transplantation 2012
  31. Porteous Mary, Diamond Joshua M, Meyer Nuala J, Lederer David J, Kawut Steven M, Lee James, Cantu Edward, Palmer Scott M, Weinacker Ann, Bhorade Sangeeta, Lama Vibha N, Orens Jonathan, Sonett Joshua, Crespo Maria M, Wille Keith M, Weill David, Demissie Ejigayehu, Reynolds John M, Belperio John A, Wilkes David S, Ware Lorraine B, Christie Jason D : Association Of Angiopoietin-2 Plasma Levels And Development Of Primary Graft Dysfunction Following Lung Transplantation  American Journal of Respiratory and Critical Care Medicine Page: A3762, May 2012 Notes: American Thoracic Society 2012.

Book Chapters

  1. Cantu E, D’Amico TA. Thoracoscopic Pulmonary Resection. Pappas TN, Pryor AD, Harnisch MP, eds. Atlas of laparoscopic surgery. 3rd ed. Philadelphia: Current Medicine; 2007.
  2. Cantu E, Milano CA, Smith PK. Critical Care for the Adult Cardiac Patient. In Sellke FW, Del Nido PJ, Swanson SJ, Sabiston DC, Spencer FC, eds. Sabiston & Spencer: Surgery of the Chest. 7th ed. Philadelphia, Pa.: Elsevier Saunders; 2009.
  3. Cantu E, Zaas DW. Organ Donor Management and Procurement. In Klein AA, Lewis C, Madsen J, eds. Organ Transplantation: A Clinical Guide. 1st ed. United Kingdom:  Cambridge University Press; 2011.

Dr. Edward Cantu

 
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