penn medicine
penn surgery
penn surgery home penn surgery clinical penn surgery education penn surgery research penn surgery administration

Scott M. Damrauer, M.D.
Vascular Surgery and Endovascular Therapy

 
  • Profile Home
  • Appointments
  • Education
  • Memberships
  • Research
  • Publications

Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
4 Silverstein Pavilion
Philadelphia, PA 19104
Administrative Assistant: Kelly Drozd
Administrative Telephone: 215-615-1698
Administrative Fax: 215-614-0463
Patient Appointments: 215-615-4949

Clinical Office:
Perelman Center for Advanced Medicine
Penn Heart and Vascular Center
East Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104

Contact Information (internal use only)

Scott.Damrauer@uphs.upenn.edu

 

Dr. Scott Damrauer is a faculty member in the Division of Vascular Surgery and Endovascular Therapy and an attending surgeon at the Hospital of the University of Pennsylvania. Before joining the faculty, he completed his general surgery training at Massachusetts General Hospital and his vascular surgery fellowship at the Hospital of the University of Pennsylvania. Dr. Damrauer uses a combination of open surgery and minimally invasive endovascular techniques to treat a variety of vascular conditions, including carotid artery stenosis, thoracic and abdominal aortic aneurysms, renal and visceral artery stenosis, peripheral arterial aneurysms, and peripheral vascular disease. His current research involves patient oriented studies that employ genomic approaches to understanding the pathophysiology of vascular disease.

 
Faculty Appointments
2014 – present  Instructor in Surgery
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 

Hospital Appointments

2014 – present  Attending Physician, Department of Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2014 – present  Attending Physician, Department of Surgery
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2014 – present  Physician, Surgical Service
Philadelphia VA Medical Center
Philadelphia, Pennsylvania
 
Education/Training
2012 – 2014 Postgraduate Vascular Surgery Fellow
Hospital of the University of Pennsylvania
 
2010 – 2012 Resident in Surgery
Massachusetts General Hospital
 
2007 – 2010 Research Fellow in Surgery, Center for Vascular Biology Research
Beth Israel Deaconess Medical Center
 
2004 – 2007 Resident in Surgery
Massachusetts General Hospital
 
1999 – 2004  MD, Harvard Medical School
Boston, Massachusetts
 
1995 – 1999 AB, Biochemistry, Harvard College
Cambridge, Massachusetts
 
Memberships/Societies
 
National and International Societies
2014 – present  American College of Surgeons, associate member
 
2014 – present Society for Vascular Surgery, candidate member
 
2014 – present American Heart Association, member
 
Regional and Local Societies
2014 – present Delaware Valley Vascular Society
   
 
Research

Dr. Damrauer’s research leverages genomic techniques to characterize the biological pathways and cellular mechanisms that are most relevant for vascular disease. In the context of patient-oriented research protocols, he is using next-generation DNA sequencing in two important groups: individual patients with severe and/or early-onset vascular disease, and families with highly penetrant vascular disease. This will identify specific mutated genes underlying the patients’ disease and allow their isolation for study in in vitro and in vivo model systems. Understanding the molecular mechanisms that underlie these specific, rare forms of vascular disease will have mechanistic relevance for more common forms of vascular disease, and is a promising strategy to develop innovative, targeted treatments. He is additionally using state-of-the art proteomic techniques to identify biomarkers that can be used to detect and monitor the progression of vascular disease without the need for imaging studies. This work is being done collaboratively with Dr. Dan Rader in the Division of Cardiology and the Penn Cardiovascular Institute.

 
Publications
Research Publications, peer-reviewed
  1. Schecter, L.M., Damrauer, S.M., Lee, C.A.: Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter. Molecular Microbiology 32:629-642, 1999
  2. Damrauer, S.M., Defina, R., He, H., Haley, KJ., and Perkins, D.L.: Molecular profiles of allograft rejection following inhibition of CD40 ligand costimulation differentiated by cluster analysis. Journal of Leukocyte Biology 71:348-358, 2002
  3. Hongo, D., Hadidi, S., Damrauer, S., Garrigue, V., Kraft, D., Sachs, D.H., Nikolic, B., Sykes, M.: Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. Journal of Infectious Diseases 196:900-910, 2007
  4. Damrauer, S.M., Bordeianou, L., Berger., D.: Contained anastomotic leaks: are we too slow to act? Archives of Surgery 144:333-338, 2009
  5. Ramsey, H.E., da Silva, C.G,, Longo, C.R., Csizmadia, E., Studer, P., Patel, V.I., Damrauer, S.M., Siracuse, J.J., Daniel, S., Ferran, C.: A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. Liver Transplantation 15:1613-1621, 2009
  6. Kopcow., H., Eriksson, M., Mselle, T.F., Damrauer, S.M., Wira, C.R., Sentman, C.L., Strominger, J.L.: Human Decidual NK Cells from Gravid Uteri and NK Cells from Cycling Endometrium are Distinct NK Cell Subsets. Placenta 211:404-448, 2010
  7. Damrauer, S.M.*, Fisher, M.D.*, Wada, W., Siracuse, J.J., da Silva, C.G., Moon, K., Csizmadia, E., Maccariello, E.R., Patel, V.I., Aird, W.C., Daniel, S., Ferran, C.: A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis 211:404-8, 2010
  8. Feng, J,*, Damrauer, S.M.*, Lee., M., Selke, F.W., Ferran, C., Abid, M.R.: Endothelium-dependent Coronary Vasodilatation Requires NADPH Oxidase-derived ROS. Arteriosclerosis, Thrombosis, and Vascular Biology 30:1703-1710, 2010
  9. Shrikhande, G.V., Scali, S.T., da Silva, C.G., Damrauer, S.M., Cszimadia, E., Putheti, P., Matthey, M., Arjoon, R., Patel, R., Siracuse, J.J., Maccariello, E.R., Anderson, N.D., Monahan, T., Peterson, C., Essayagh, S., Studer, P., Guedes, .R.P., Kocher, O., Usheva, A., Veves, A., Kaczmarek, E., Ferran, C.: O-Glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice. PLoS ONE 5:e14240, 2010
  10. Damrauer, S.M.*, Studer, P.*, da Silva, G.C., Longo, C., Ramsey, H.E., Csizmadia, E., Shrikhande, G., Scali, S.T., Liberman, T.A., Bhasin, M.K., Ferran, C.: A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE 6:e17715, 2011
  11. da Silva, C.G., Maccariello, E.R., Wilson, S.W.,  Putheti, P., Daniel, S., Damrauer, S.M., Peterson, C., Siracuse, J.J., Kaczmarek, E., Ferran, C.: Hepatocyte Growth Factor preferentially activates the anti-inflammatory arm of NF-κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation. Journal of Cellular Physiology 27:1382-1390, 2012
  12. Siracuse, J.J., Fisher, M.D., da Silva, C.G., Peterson, C.R., Csizmadia, E., Moll, H.P., Damrauer, S.M., Studer, P., Choi, L.Y., Essayagh, S., Kaczmarek, E., Maccariello, E.R., Lee, A., Daniel, S., Ferran, C.: A20-mediated modulation of inflammatory and immune responses in aortic allografts and development of transplant arteriosclerosis. Transplantation 93:373-382, 2012
  13. Trubelja, A., MacArthur Jr, J.W., Sarver, J.J., Cohen, J.E., Hung, G., Shudo, Y., Fairman, A.S., Patel, J.B., Edwards, B.B., Damrauer, S.M., Hiesinger, W., Atluri, P., Woo, Y.J. Bioengineered SDF-1a Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle. Journal of Biomechanical Engineering [Epub ahead of print] 2014

                         * equally contributing co-first author

Editorials, Reviews, Chapters, and Other Publications
  1. Damrauer, S.M., Vora, S.R. Anatomy of the Eye and Orbit. In Chern, K. (Ed.)  Emergency Ophthalmology, McGraw Hill, New York, 2002.
  2. Vora, S.R., Damrauer, S.M., Basic Opthalmology Exam. In Chern, K. (Ed.)  Emergency Ophthalmology, McGraw Hill, New York, 2002
  3. Damrauer, S.M., Galanter, J.M., Cardozo, D.L. Pharmacology of Dopaminergic Neurotransmission. In Golan, D.E., Tashjian, A.H., Jr., Armstrong, E.J., Galanter, J.M., Armstrong, A.W., Arnaout, R.A., and Rose, H.S. (Eds.) Principles of pharmacology. The pathophysiologic basis of drug therapy, Lippincott Williams & Wilkins, Philadelphia, 2005.
  4. Damrauer, S.M., Woo, E.Y. The sandwich approach to TAAA treatment. Endovascular Today, September 2012
  5. Woo, E.Y., Damrauer, S.M. Abdominal aortic aneurysms: Open surgical treatment. in Cronewett, J.L., and Johnston, K.W. (Eds.) Rutherford’s Vascular Surgery 8th ed., Saunders Elsevier, Philadelphia.
  6. McGillicuddy, F.C., Moll, H.P., Farouk, S., Damrauer, S.M., Ferran, C., Reilly, M.P. Translational studies of A20 in Athersclerosis and Casciovascular Disease. in Ferran, C. (Ed.) TheMultiple Therapeutic Targets of A20, Landes Biosceince, Austin, [in press]
  7. Woo, E.Y., Damrauer, S.M. Extra-thoracic Revascularization. in Mullholand, M., Hughes, S., Hawn, M., Sabel, M., Albo, D., Englesbe, M., & Dalman, R. (Eds.) Operative Techniques in Surgery, Lippincott Williams & Wilkins, Philadelphia, [in press].
  8. Damrauer, S.M., Jackson, B.M. Open Surgical Management of Aortoiliac Occlusive Disease. in Lanzer, P. (Ed.) PanVascular Medicine 2e, Springer, Berlin, [in press].
Abstracts
  1. Damrauer, S.M., Mueller, T., and Perkins, D.L. Transcriptional profiling of allograft rejection. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001, Chicago, IL.
  2. Damrauer, S.M., Mueller, T., Buckley, M., Stone, J., Perkins, D.L. Robust chemokine and inflammatory response by the innate immune response after transplantation. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001, Chicago, IL.
  3. Mueller, T., Damrauer, S.M., Buckley, M., Stone, J., Perkins, D.L. Differential inflammatory and chemokine responses by the innate and adaptive immune responses after transplantation. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001. Chicago, IL.
  4. Damrauer, S.M., Garrigue, V., Nikolic, B., and Sykes, M. Porcine thymic tissue can support human thympoiesis that is resistant to HIV-1 mediated destruction.  Poster presentation at the Federation of Clinical Immunology Societies 3rd Annual Meeting, May 2003, Paris, France.
  5. Maccariello, E., Silva, C., Daniel, S., Damrauer, S.M., Choi, L.Y., Siracuse, J.J., Kaczmarek, E., Ferran, C. Hepatocyte growth factor upregulates A20 in renal proximal tubular epithelial cells: A potential protective preconditioning regimen in kidney transplantation. Oral presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  6. Siracuse, J.J., Fisher, M.D., Csizmadia, E., Damrauer, S.M., Choi, L.Y., da Silva, C.G., Moon, K., Maccariello, E., Daniel, S., Ferran, C. A20 prevents transplant arteriosclerosis in a model of aortic allograft. Poster presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  7. Damrauer, S.M., Fisher, M.D., Scali, S.T., Wada, H., da Silva, C.G., Csizmadia, E., Maccariello, E.R., Moon, K., Siracuse, J.J., Bolash, R., Aird, W., Daniel, S., Ferran, C. Combined anti-infammatory and anti-angiogenic functions of A20 in the vessel wall: Implications for transplant arteriosclerosis. Poster presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  8. Choi, L., Sali, S., da Silva, C., Clermont, A., Csmadia, E., Fisher, M., Damrauer, S.M., Siracuse, J.J., Young, M., Benjamin, L., Daniel, S., Ferran, C. A novel anti-angiogenicf function of A20: implications in diabetic retinopathy. Poster presentation at the 15th International Vascular Biology Meeting, June 2008, Sydney, Australia.
  9. Siracuse, J.J., Fisher, M.D., Csizmadia, E., Damrauer, S.M., Choi, L.Y., da Silva, C.G., Moon, K., Maccariello, E., Daniel, S., Ferran, C. A20 protects against accelerated atherosclerosis in aortic allografts. Oral presentation at the Society for Vascular Surgery Annual Meeting, June 2008, San Diego, CA.
  10. Damrauer, S.M., Fisher, M.D., Scali, S.T., Wada, H., da Silva, C.G., Csizmadia, E., Maccariello, E.R., Moon, K., Siracuse, J.J., Bolash, R., Aird, W., Daniel, S., Ferran, C. The atheroprotective molecule A20 inhibits post-angioplasty restenosis by both anti-inflammatory and anti-angiogenic pathways. Poster presentation at the Society for Vascular Surgery Annual Meeting, June 2008, San Diego, CA.
  11. Siracuse, J.J., da Silva, C.G., Damrauer, S.M., Fisher, M.D., Studer, P., Skroch, M., Choi, L.Y., Csizmadia, E., Kaczmarek, E., Daniel, S., Ferran, C. A20's Opposite Effect on CD40 Expression in Endothelial Cells and Smooth Muscle Cells Underscores its Atheroprotective Potential. Oral presentation at the 2009 SVS Research Initiatives in Vascular Disease, April 2009, Washington, DC.
  12. Siracuse, J.J., da Silva, C.G., Damrauer, S.M., Fisher, M.D., Studer, P., Skroch, M., Choi, L.Y., Csizmadia, E., Kaczmarek, E., Daniel, S., Ferran, C. Opposite effects of A20 upon CD40 expression in EC and SMC: Implication in A20’s protective effect against transplant associated vasculopathy. Poster presentation at the American Transplant Congress, May 2009, Boston, MA.
  13. Daniel, S., Kaczmarek, E., Choi, L., Fisher, M.D., Siracuse, S.S., Csizmadia, E., Damrauer, S.M., Studer, P., da Silva, C.G., Ferran, C. A20 increases the expression of endothelial and inducible nitric oxide synthases in endothelial and smooth muscle cells to protect from transplant arteriosclerosis. Poster presentation at the American Transplant Congress, May 2009, Boston, MA.
  14. da Silva, C.G., Skroch, M., Studer, P., Damrauer, S.M., Siracuse, J.J., Maccariello, E., Kaczmarek, E., and Ferran, C. The pro-proliferative effects of A20 map to the 7-Zinc finger domain: A means to define small peptides with therapeutic potential. Poster presentation at the American Transplant Congress, May 2009, Boston, MA.
  15. Damrauer, S.M., Csizmadia, E., Studer, P., Bhasin, M., DaSilva, C.G., Peterson, C.R., Ferran. C. Partial Loss of A20 (Tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysms. Poster presentation at Arteriosclerosis, Thrombosis, and Vascular Biology, April 2010, San Francisco, CA.
  16. Peterson, C., Siracuse, J.J.,Fisher, M., DaSilva. C., Csizmadia, E., Damrauer, S.M., Studer, P., Essayagh, S., Kaczmarek, E., Ferran, C. A20 Protects Vascular Allografts from Transplant Arteriosclerosis by Modulating Inflammatory and Apoptotic Responses to Skew the Immune Response. Oral presentation at the American Transplant Congress, May 2010, San Diego, CA.
  17. Studer, P., da Silva, C., Csizmadia, E., Damrauer, S.M., Peterson, C., Siracuse, J., Essayagh, S., Kaczmarek, E., Candinas, D., Stroka, D., Ferran, C. Delayed Liver Regeneration in Mice with Partial A20 Knockdown Underscores the Central Role of A20 in the Liver. Oral presentation at the American Transplant Congress, May 2010, San Diego, CA.
  18. da Silva, C., Studer, P., Csizmadia, E., Damrauer, S.M., Peterson, C., Kaczmarek, E., Essayagh, S., Candinas, D., Stroka, D., Ferran, C. Delayed Liver Regeneration in Mice with Partial A20 Knockdown Underscores the Central Role of A20 in the Liver. Poster presentation at the American Transplant Congress, May 2010, San Diego, CA.
  19. Studer, P., da Silva, C., Damrauer, S.M., Longo, C., Bhasin, M., Libermann, T., Inderbitzin, D., Candinas, D., Stroka, D., Ferran, C. Gene chip analysis of A20 expressing livers following extended resection uncovers its multiple targets that promoter liver repair and regeneration. Poster presentation at the Jahreskongress der Schweizerischen Gesellschaft für Chirurgie May 2010, Interlaken, Switzerland.
  20. Studer, P., da Silva, C., Csizmadia, E., Damrauer, S.M., Peterson, C., Kaczmarek, E., Essayagh, S., Candinas, D., Stroka, D., Ferran C. The Protective effect of A20 against severe liver ischemia reperfusion injury is abolished in PPARa-null mice. Oral presentation at the Jahreskongress der Schweizerischen Gesellschaft für Chirurgie May 2010, Interlaken, Switzerland.
  21. da Silva, C.G., Shrikhande, G., Shrikhande, G.V., Scali, S.T., Damrauer, S.M., Csizmadia, E., Matthey, M., Kaczmarek, E., Ferran, C. Glucose-mediated loss of vascular A20 contributes to accelerated atherosclerosis in diabetes. Oral presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, September 2010, Boston, MA.
  22.  Peterson, C.R., Siracuse, J.J., Fisher, M.D., da Silva, C.G., Csizmadia, E., Damrauer, S.M., Studer, P., Essayagh, S., Kaczmarek, E., Ferran, C. Vascular remodeling in Transplant Arteriosclerosis: the role of A20. Oral presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, September 2010, Boston MA.
  23. Damrauer, S.M., Peterson, C.R., Studer, P., Marusyk, V.L., Csizmadia, E., da Silva, C.G., Ferran, C. Partial Loss of A20 (tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysm. Poster presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, September 2010, Boston, MA. 
  24. Damrauer, S.M., Peterson, C.R., Studer, P., Marusyk, V.L., Csizmadia, E, da Silva, C.G., Ferran C. Partial Loss of A20 (Tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysms Through Altering Smooth Muscle Cell Differentiation. Oral presentation at the American College of Surgeons 96th Annual Clinical Congress, October 2010, Washington, DC.
  25. Damrauer, S.M., Quatromoni, J., Wang, G.J., Jackson, B.M., Fairman, R.M., Woo, E.Y. Endovascular Aneurysm Repair and Follow-up: Foregoing the One-month CTA. Poster presentation at the Society for Clinical Vascular Surgery 42nd Annual Symposium, March 2014, Carlsbad, CA.
  26. Damrauer, S.M., Zhao, W., Fairman, R.M., Rader, D.J., Saleheen, D. Risk factors for lower extremity claudication in South Asians. Oral presentation at the Delaware Valley Vascular Society 2014 Annual Meeting, April 2014, Phildelphia, PA.
  27. Damrauer, S.M., Zhao, W., Fairman, R.M., Rader, D.J., Saleheen, D. Risk factors for lower extremity claudication in South Asians. Poster presentation at Atherosclerosis, Thrombosis, and Vascular Biology Scientific Sessions 2014, May 2014, Toronto, Canada.
  28. Damrauer, S.M., Zhao, W., Fairman, R.M., Rader, D.J., Saleheen, D. Genetic determinants of lower extremity claudication in South Asians. Poster presentation at Atherosclerosis, Thrombosis, and Vascular Biology Scientific Sessions 2014, May 2014, Toronto, Canada.
  29. Damrauer, S.M., Desai, N., Wang, X., Wang, G.J., Jackson, B.M., Woo, E.Y., Bavaria, J.E., Fairman, R.M. Impact of acute post-operative limb ischemia following cardiac and thoracic aortic surgery. Rapid-paced paper presentation at the 2014 Vascular Annual Meeting, Society for Vascular Surgery, June 2014, Boston, MA.
  30. Damrauer, S.M., Gaffey, A.C., Smith, A.D., Fairman, R.M., Nguyen, L.L. Comparison of Risk Factors for Length of Stay and Readmission Following Lower Extremity Revascularization. Oral presentation at the 2014 Joint Annual Meeting of the New England Society for Vascular Surgery and the Eastern Vascular Society, September 2014, Boston, MA [accepted].
  31. Damrauer, S.M., Gaffey, A.C., Smith, A.D., Fairman, R.M., Nguyen, L.L. When to Start Counting: Differences in 30-day After Procedure and 30-day After Discharge Readmissions Following Lower Extremity Revascularization. Oral presentation at Surgical Forum of the American College of Surgeons 2014 Clinical Congress, October 2014, San Francisco, CA [accepted].
  Other Presentations
  1. Damrauer, S.M., Woo, E.Y. Renal Artery Aneurysms. Case presentation and panel discussion at the Annual Meeting of the Delaware Valley Vascular Society, April 2013, Philadelphia, PA.
  2. Damrauer, S.M., Jackson, B.M. Removal of a Percutaneous removal of a Greenfield Filter that had been in place for greater than 12 years. Case presentation at the Fall Meeting of the Delaware Valley Vascular Society, October 2013, Atlantic City, NJ.
  3. Damrauer, S.M.,Woo, E.Y. Combined antegrade and retrograde recannulization of the superficial femoral artery for critical limb ischemia. Case presentation at the Veith Fellowluminaries Case Competition, VEITHsymposium, November 2013, New York, NY.
  4. Damrauer, S.M., Fairman, R.M. An 18-year old with severe lifelong hypertension. Oral case presentation at the Society for Clinical Vascular Surgery 42nd Annual Symposium, March 2014, Carlsbad, CA.
  5. Damrauer, S.M., Fairman, R.M. A 36 year-­‐old with Marfan’s disease that had undergone a thoracoabdominal aortic aneurysm repair. Oral case presentation at the Society for Clinical Vascular Surgery 42nd Annual Symposium, March 2014, Carlsbad, CA.
  6. Damrauer, S.M., Quatromoni, J., Wang, G.J., Jackson, B.M., Fairman, R.M., Woo, E.Y. Endovascular Aneurysm Repair and Follow-up: Foregoing the One-month CTA. Oral presentation at the 30th Annual Vascular Fellows Abstract Competition, May 2014, New York, NY.
  7. Invited discussant of “Healthcare Delivery Redesign for EVAR Leads to Quality Improvement and Cost Reduction,” by Warner, C.W. et al. presented at the Vascular and Endovascular Surgery Society Paper Session of the 2014 Vascular

Dr. Scott Damrauer

 
footer Terms of Use Legal Disclaimer Site Map Contact Us Financial Assistance About Penn Medicine Privacy Statement
penn medicine