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Edward J. Doolin, M.D., F.A.C.S., F.A.A.P.
Pediatric Surgery

 
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  • Education
  • Memberships
  • Research
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Administrative Office:
Children’s Hospital of Philadelphia
34th Street & Civic Center Boulevard
5th Floor, Wood Center
Philadelphia, PA 19104
Administratice Telephone: 215-590-8846
Administrative Fax: 215-590-4875
Patient Appointments: 215-590-8846

Clinical Offices:
Laurel Oak Corporate Center
1012 Laurel Oak Road, Suite 1
Voorhees, NJ 08043
Clinical Telephone: 856-435-1300

4009 Black Horse Pike
Mays Landing, NJ 08330
Clinical Telephone: 609-677-7895

doolin@email.chop.edu

Link to Children's Hospital of Philadelphia

 

Special Interests: Thoracic surgery anorectal surgery and airway surgery

 
Faculty Appointments
1986 - 1992 Assistant Professor of Surgery and Pediatrics
Division of Pediatric Surgery
UMDNJ/Robert Wood Johnson Medical School
Camden, New Jersey
 
1992 - 1995 Associate Professor of Clinical Surgery and Pediatrics
UMDNJ/ Robert Wood Johnson Medical School
Camden, New Jersey
 
1996 - 2000 Associate Professor of Surgery and Pediatrics
Division of Pediatric Surgery
UMDNJ/Robert Wood Johnson Medical School
Camden, New Jersey
 
2000 - 2001 Professor of Surgery and Pediatrics
Division of Pediatric Surgery
UMDNJ/Robert Wood Johnson Medical School
Camden, New Jersey
 
2001 - present Clinical Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
1986 - 2001 Pediatric Surgeon
Division of Pediatric Surgery Cooper Hospital/University Medical Center
Camden, New Jersey
 
1988 - 1999 Head, Section of Pediatric Trauma
Division of Trauma, Department of Surgery
Cooper Hospital/University Medical Center
Camden, New Jersey
 
1986 – present Active Staff, Our Lady of Lourdes Medical Center
Camden, New Jersey
 
1987 – present Active Staff, Memorial Hospital of Burlington County
Mt. Holly, New Jersey
 
1987 – 2000 Associate Staff, St. Christopher's Hospital for Children
Philadelphia, Pennsylvania
 
1989 – present Active Staff, West Jersey/Virtua Hospital
Voorhees, New Jersey
 
1991 – present Consulting Staff, Children's Seashore House
Philadelphia, Pennsylvania
 
1997 – 2000 Active Staff, Temple University – Children’s Medical Center
Philadelphia, Pennsylvania
 
1998 - 2000 Director-Pediatric Trauma, Department of Surgery
Temple University Medical Center
Children’s Medical Center
Philadelphia, Pennsylvania
 
2001 - present Director, PACE Clinic
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2001 - present Active Staff, Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
Education/Training
1971 - 1975 B.S. Georgetown University
 
1975 - 1979 M.D. Northwestern University Medical School
 
Postgraduate Training and Fellowship Appointments
1979 - 1980 Intern in General Surgery,
University of Maryland Hospital
Baltimore, Maryland
 
1980 - 1984 Residency, General Surgery,
University of Maryland Hospital
Baltimore, Maryland
 
1984 - 1986 Fellowship, Pediatric Surgery,
The Children’s Memorial Hospital
Chicago, Illinois
 
Memberships/Societies
National Societies
  • Academy of Surgical Research
  • American Academy of Pediatrics (Fellow)
  • American Academy of Pediatrics (Surgical Section)
  • American Association for the Advancement of Science
  • American Association for the Surgery of Trauma
  • American Bronchoesophagologic Association
  • American Burn Association
  • American College of Surgeons (Fellow)
    • ACS New Jersey Committee on Trauma, 1994-present
    • New Jersey Chapter Membership Committee, 1996-present
  • American Medical Association
  • American Pediatric Surgical Association
    • Informatics Committee, 1997-present
    • Education Committee, 1996-present
    • Committee of Trauma, 1991-1997
  • Association of Academic Surgeons
  • Eastern Association for the Surgery of Trauma
  • Society of Critical Care Medicine
  • Tissue Engineering Society
  • University of Maryland Surgical Society
Regional/Local Societies
  • Camden County Medical Society
  • College of Physicians of Philadelphia
  • Medical Society of New Jersey
  • New Jersey Surgical Society
  • Philadelphia Academy of Surgery
Scientific Committees
  • American Burn Association Research SIG
    • Co-Chairperson, 1998
    • Chair, 1999
 
Research
Research Publications, peer reviewed
  1. Doolin EJ and Drueck C III. Fatal iron intoxication in an adult. J Trauma 20(6):518 521, June 1980.
  2. Doolin EJ. A subfascial stent for Hesselbach's triangle and difficult fascial closures. Surg Gynecol Obstet. 157(4):371 372, Oct. 1983.
  3. Richards WO, Doolin EJ, Maginski MP, Moulton AL. Pharmacologic inhibition of scar contracture of intracardiac prosthetic patches. J Surg Res 37(1):33 42, July 1984.
  4. Doolin EJ, Luck SR, Sherman JV, Raffensperger JL: Emergency lung biopsy: Friend or foe of the immunosuppressed child? J Ped Surg 21(6):485 487, June 1986.
  5. Doolin EJ, Ormsbee HS, Hill JL. Motility abnormality in intestinal atresia. J Pediatr Surg 22(4):320 324, Apr. 1987.
  6. Doolin EJ, Goldstein H, Kessler B, Vinocur C, Marchildon MB. Familial retroperitoneal fibrosis. J Pediatr Surg 22(10):1092 1094, Dec. 1987.
  7. Mure AJ, Unkle DW, Doolin EJ, Ross SE. Blunt aortic trauma following deceleration in a seven-year-old. Pediatr Emerg Care 6(2):104-105, June 1990.
  8. Sweeney RL, Doolin EJ, Ross SE. Hematuria in injured children: Is emergency radiographic evaluation mandatory? Ann Emerg Med 20(4):473, 1991.
  9. Sweeney R, Doolin EJ: Head and neck trauma in children. Topics in Emergency Medicine (Ross SR, ed.), 78-84, 1991.
  10. Doolin EJ, Black CT, Donaldson J, Schwartz D, Raffensperger JG. Rectal manometry computed tomography and functional results of anal atresia surgery. J Pediatr Surg 28(2):95-198, Feb. 1993.
  11. Doolin EJ. Esophageal stricture: An uncommon complication of foreign bodies. Ann Otol Rhinol Laryngol 102(11):863-866, Nov. 1993.
  12. Doolin EJ. Composite reconstruction of the esophagus and hypopharynx after severe caustic injury. Ann Otol Rhinol Laryngol 103(1):36-40, Jan. 1994.
  13. Heether J, Whalen TV, Doolin EJ. Follow up of complex unresectable lymphangiomas. Am Surgeon 60(11):840-841, Nov. 1994.
  14. Doolin EJ, Strande L. Calibration of endoscopic images. Ann Otol Rhinol Laryngol 104(1):19-23, Jan. 1995.
  15. Stein SC, Doolin EJ. Management of minor closed head injury in children and adolescents. Pediatr Surg Int 10:465-471, 1995.
  16. Puglisi RN, Doolin EJ, Hewitt CW. Morphometric analysis of rat renal allograft tolerance by computerized digital image processing. Transplant Proc 27(1):555-556, Feb. 1995.
  17. Puglisi RN, Whalen TV, Doolin, EJ. Computer analyzed histology of ischemic injury to the gut. J Pediatr Surg 30(6):839-844, June 1995.
  18. Hewitt CW, Englesbe MJ, Tatem LD, Strande LF, Doolin EJ, Dalsey RM, DeLong WG. Graft versus host disease in extremity transplantation: Digital image analysis of bone marrow in situ. Ann Plast Surg 35(1):108-112, July 1995.
  19. Doolin EJ, Strande L, Attorri RJ. Morphometry and histochemistry of pulmonary arteries in a hypoplastic lung model. J Surg Res 59(1):191-197, July 1995.
  20. Santos M, Strande L, Doolin EJ. Airway measurement using morphometric analysis. Ann Otol Rhinol Laryngol 104(11):835-838, Nov. 1995.
  21. Puglisi RN, Strande, LF, Hewitt, CW, Whalen TV, Doolin EJ. The effect of cyclosporin in gut ischemic injury: A computerized morphometric and enzymatic analysis. J Pediatr Surg 31(2):319-322, Feb. 1996.
  22. Strande LF, Foley ST, Doolin EJ, Hewitt CW. In vitro bioartificial skin culture model of tissue rejec-tion and inflammatory/immune mechanisms. Transplant Proc 29(4):2118-2119, June 1997.
  23. Hewitt C W, Strande L, Santos M, Goodman M, Tarnoff M, Zaontz MR, DelRossi AJ, Doolin ER. Rat renal allograft tolerance is associated with local TGF-ß and absence of IL-2r expression within chimeric immunocytic foci. Transplant Proc 29(4):2183-2184, June 1997.
  24. Doolin EJ, Tsuno K, Strande LF, Santos MC. Pharmacologic inhibition of collagen in an experimental model of subglottic expression within chimeric immunocytic foci. Ann Otol Rhinol Laryngol 107(4): 275-279, Apr. 1998.
  25. Ramsamooj R, Strande L, Kain M, Doolin EJ, Hewitt CW. A novel in vitro model for xenorejection and immune mechanisms using bioengineered living skin equivalents. Transplant Proc 30(4):1087-1088, June 1998.
  26. Chen MK, Strande L, Kain M, Whalen TV, Doolin EJ. Induction of apoptosis in a neuroblastoma and hepatocyte coculture model. J Surg Res 78(2):123-130, Aug. 1998.
  27. Hewitt CW, Tarnoff M, Goodman M, Ramsamooj R, Chin V, Doolin EJ. Use of 3-D microscopy with multiple oblique illumination in evaluating cytopathology preparations. Anal Quant Cytol Histol 21(2):139-142, Apr. 1999.
  28. Doolin EJ, Browne AM, DiScala C. Pediatric trauma center criteria: An outcome analysis. J Ped Surg 34(5):885-890, May 1999.
  29. Chen MK, Strande LF, Beierle EA, Kain MS, Geldziler BD, Doolin EJ. FAS-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model. J Surg Res 84(1):82-87, June 1, 1999.
  30. Doolin EJ, Strande L, Chen MK, Kain M, Hewitt CW. The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model. J Burn Care Rehabil 20(5):374- 376, Sept./Oct. 1999.
  31. Suzuki H, Hewitt CW, Tran H, Puc MM, Patel N, Matthews M, Dalsey R, Doolin EJ, DelRossi AJ. Ramsamooj R, Greenberg G, Doolin EJ, Hewitt CW. Three-dimensional microscopy for evaluating cytology specimens: A possible "pap" smear. Focus (Papanicolaou Society of Cytopathology) 6(2):6, 1999.
  32. Doolin EJ, Geldziler B, Strande L, Kain M, Hewitt CW. The effects of microgravity on growing cultured skin constructs. Tissue Engineering 5(6):573-582, Dec. 1999.
  33. Suzuki H, Patel N, Matthews M, DelRossi AJ, Doolin EJ, Hewitt CW. Vascularized bone marrow transplantation: A new surgical approach utilizing isolated femoral bone/bone marrow. J Surg Res 89(2):176-183, Apr. 2000.
  34. Puc MM, Chrzanowski FA, Tran H, Geldziler B, Martucci M, Doolin EJ, Hewitt CW. Multiple oblique illumination and high definition microscopy for breast fine needle aspirates. J Invest Surg 13(1):1-5, Jan./Feb. 2000.
  35. Bierle EA, Chen MK, Whalen TV, Doolin EJ. Free fluid on abdominal computed tomography scan after blunt trauma does not mandate exploratory laparotomy in children. J Ped Surg 35(6):990-993, June 2000.
  36. Doolin EJ, Strande LF, Sheng X, Hewitt CW. Engineering a composite neotrachea with surgical adhesives. J Ped Surg 37(7):1034-1037, July 2002.
  37. Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW, Doolin EJ. Computer-assisted stereology: Point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning 25(1):37-44, Jan./Feb. 2003.
  38. Redden RA, Doolin EJ. Collagen crosslinking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Research & Technology 9(3):290-293, Aug. 2003.
  39. Reviews in Peer-Reviewed Research Publications
    Amin A, Alexander JB, O'Malley KF, Doolin EJ. Blunt abdominal aortic trauma in children. J Trauma 34(2):293-296, Feb. 1993.
  40. Doolin E. Bowel management for patients with myelodysplasia. [Review] Surgical Clinics of North America 86(2):505-514, xi, Apr. 2006.
Research Publications, non-peer reviewed
  1. Doolin EJ, Ormsbee HS, Hill JL. Experimental intestinal atresia, motility, and physiology. Surg Forum 35: 171 172, 1984.
  2. Doolin EJ. Airway reconstruction in children. Current Surgery 51(1):5-9, 1994.
    3. Santos MC, Strande L, Doolin EJ. Oligohydramnios does not alter myometrial response to cholinergic stimuli. Surg Forum 46, 1995.
  3. Hewitt C, Doolin E, Achauer B, Foley ST. Burn research without animals. Good Medicine 5(2):9-10, 1996.
  4. Hewitt C, Goodman M, Tarnoff M, Ramsamooj R, Doolin E. Use of multiple oblique illumina-tion and 3-D microscopy in cytopathology. Biomedical Products Magazine 7:138-139, 1997.
  5. Goodman MD, Tarnoff ME, Strande LF, Tatem L, Kain MS, Doolin EJ, DelRossi AJ, Hewitt CW. The relationship between in situ chimerism, local TGF-ß and IL-2r expression in rat allograft tolerance. Surg Forum 48:508-509, 1997.
  6. Doolin EJ. Composite tissue/vascularized bone marrow transplantation: A hierarchy of tissue tolergenicity. Graft 2(3):111-115, 1999.
  7. Redden RA, Doolin EJ. Collagen cross linking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Research & Technology 9(3):290-293, Aug. 2003.
 
Publications
Abstracts
  1. Barone FC, White RF, Doolin EJ, et al. Similar extracellular calcium requirement for human and canine colon circular muscle contractions. Gastroenterology 95(3):856, 1988.
  2. Doolin EJ, Strande L, Hewitt C. Immunochemical analysis of tolerance rat kidney allografts. The FASEB Journal 9(3): 1995.
  3. Puglisi RN, Doolin EJ, Whalen TV, Hewitt CW. Analysis of pentoxifylline in gut ischemia using computerized digital image processing. The FASEB Journal Vol. 9(4), p.A954, 1995.
  4. Puglisi RN, Strande LF, Santos M, Doolin EJ, Hewitt CW, Whalen TV. The effect of cyclosporine in gut ischemia: A computerized morphometric and analysis. Proceedings of the American Pediatric Surgical Association 26th Annual Meeting, Vol. 26, p. 201, 1995.
  5. Foley ST, Strande L, Doolin EJ, Hewitt CW: Novel high definition 3-D microscopy with multiple oblique illumination is beneficial for histopathologic studies of in vitro living skin equivalent. The FASEB Journal 10(6): A1290, 1996.
  6. Hewitt CW, Strande L, Santos M, Doolin E. Rat renal allograft tolerance is associated with local TGF-? and the absence of IL-2r expression within chimeric immunocytic foci. Cell Transplantation Society 5(5S-2): p.64, 1996.
  7. Strande L, Foley S, Doolin EJ, Hewitt CW. In vitro bioartificial skin culture model of tissue rejection/and inflammatory/immune mechanisms. Cell Transplantation Society 5(5S-2): p. 45, 1996.
  8. Ramsamooj R, Chin V, Tarnoff M, Goodman M, Doolin E. Use of 3-D microscopy with multiple oblique illumination in evaluating cytopathology preparations. Abstracts of the 10th International Conference on Diagnostic Quantitative Pathology, p. 17, 1996.
  9. Levin S, Lotano V, Hausen B, Wagner T, Zeltsman D, Santos M, Strande L, Hewitt CW, Doolin E. Digital image analysis of lung transplant rejection in the rat: Quantitative differences between ischemic reperfusion injury in syngeneic grafts vs. untreated allogeneic grafts. The FASEB Journal of Abstracts, p. A824, 1996.
  10. Hewitt CW, Strande L, Tatem L, Hirpara S, Santos M, Black K, Doolin E. Mechanisms of prior blood transfusion-cyclosporine induced tolerance: a role for in situ immune cellular chimerism and local TGF-expression. Abstracts of the Fifteenth Annual Meeting of the American Society of Transplant Physicians,
    p. 185, 1996.
  11. Strande L, Foley ST, Doolin EJ, Hewitt CW. In vitro bioartificial skin culture model of tissue rejection and inflammatory/immune mechanisms. Cell Transplant Society 5(5S-2): p.45, 1996.
  12. Hewitt CW, Strande L, Santos M, Goodman M, Tarnoff M, Zaontz MR, DelRossi AJ, Doolin EJ. Rat renal allograft tolerance is associated with local TGF-? and absence of IL-2r expression within chimeric immunocytic foci. Cell Transplant Society 5(5S-2) p. 64, 1996.
  13. Ramsamooj R, Chin V, Tarnoff M, Goodman M, Doolin EJ. Use of 3-D microscopy with multiple oblique illumination in evaluating cytopathology preparations. Abstracts of the 10th International Conference on Diagnostic Quantitative Pathology, p. 17, 1996.
  14. Hewitt CW, Foley S, Strande L, Achauer BM, Doolin EJ. An in vitro model for inflammatory immune mechanisms and rejection using bioartificial living skin equivalents. Proceedings of the 29th Annual Meeting of the American Burn Association. J Burn Rehabil Vol 18(1)3; p. S74, 1997.
  15. Goodman M, Tarnoff M, Hewitt CW, Doolin EJ. Mathematical evaluation of high-definition 3-D microscopy using digital imaging. The FASEB Journal, Vol. 11(3); p. A636, 1997.
  16. Goodman M, Tarnoff M, Strande L, Doolin E, Kain M, Hewitt CW. Mechanisms of rat renal allograft tolerance: The role of in situ chimerism, local TGF-? and IL-2r expression. Abstracts of the 16th Annual Meeting of the Annual Society of Transplant Physicians, p. 195, 1997.
  17. Ramsamooj R, Goodman M, Tarnoff M, Doolin E, Hewitt CW. Evaluation of thyroid fine needle aspirates (FNA=s) using high resolution 3-D microscopy with multiple oblique illumination. Abstracts of the 97th Annual Retreat on Cancer Research in New Jersey, p.40, 1997.
  18. Goodman M, Tarnoff M, Ramsamooj R, Kain M, Hewitt CW, Doolin E. Evaluation of high definition 3-D microscopy in cytopathology and PAP smear analysis. Proceedings of the 88th Annual Meeting of the American Association for Cancer Research, Vol. 38, p. 269, 1997.
  19. Goodman MD, Tarnoff ME, Strande LF, Tatem L, Kain MS, Doolin EJ, DelRossi AJ, Hewitt CW. The relationship between in situ chimerism, local TGF-? and IL-2r expression in rat allograft tolerance. Surg Forum 48: 508-509, 1997.
  20. Goodman M, Tarnoff M, Ramsamooj R, Kain M, Doolin EJ, Hewitt CW. Evaluation of high-definition 3-D microscopy in cytopathology and papsmear analysis. Abstracts of the 97th Annual Retreat on Cancer Research in New Jersey, p.22, 1997.
  21. Hewitt CW, Goodman M, Tarnoff M, Ramsamooj R, Doolin E. Microscopy utilizing multiple oblique illumination for cytopathology. Cytopathology, Vol. 8(2), p.4, 1997.
  22. Ramsamooj R, Goodman M, Tarnoff M, Doolin E, Hewitt CW. Evaluation of thyroid fine needle aspirates (FNA=s) using high resolution 3-D microscopy with multiple oblique illumination. Pathology, Research and Practice (European Journal of Pathology), Vol.193, p. 389, 1997.
  23. Hewitt CW, Tarnoff M, Goodman M, Ramsamooj R, Doolin E. High definition 3-D microscopy utilizing multiple oblique illumination offers significant advantages for analyzing cytopathology and pap smears. Pathology, Research and Practice (European Journal of Pathology), Vol.193, p. 441, 1997.
  24. Doolin EJ, Strande LF, Chen MK, Kain M, Hewitt CW. The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model. J Burn Care Rehabil, Vol.19(1)2; p. S170, 1998.
  25. Hewitt CW, Geldziler B, Ramsamooj R, Greenberg G, Doolin EJ. High definition microscopy based on multiple oblique illumination for cytopathology and pap smear analysis: Evaluation of 3-D digital image reconstruction and analysis. Abstracts of the 11th International Congress on Diagnostic Quantitative Pathology , p. 162, 1997.
  26. Chrzanowski F, Geldziler B, Goodman M, Tarnoff M, Martucci M, Doolin E, Hewitt C. Multiple oblique illumination and high definition stereo microscopy for breast fine needle aspirates. Proceedings of the American Association for Cancer Research, Vol. 39, p.55, 1998.
  27. Goodman M, Tarnoff M, Atabek U, Doolin E, Hewitt C. Utilization of high definition 3-D microscopy and multiple oblique illumination in the evaluation of thyroid fine needle aspirates. The FASEB Journal, Vol.12(4), p. 244, 1998.
  28. Chrzanowski F, Geldziler B, Goodman M, Tarnoff M, Martucci M, Doolin E, Hewitt C. Relationship of specimen thickness to image detail in breast fine needle aspirates specimens using multiple oblique illumination and high definition 3-D microscopy. The FASEB Journal, Vol. 12(4), p. 17, 1998.
  29. Chrzanowski FA, Geldziler B, Matucci M, Doolin EJ, Hewitt CW. The effect of increased specimen thickness on multiple oblique illumination and high definition stereo microscopy for breast fine needle aspirates. 14th Annual Scientific Session for The Academy of Surgical Research, 1998
  30. Geldziler B, Hewitt CW, Doolin EJ, Pro E. Depth of field of mycology specimens using high definition 3-D microscopy employing multiple oblique illumination. Abstracts of the American Society for Microbiology, p. 270, 1998.
  31. Doolin EJ, Geldziler B, Strande L, Kain M, Hewitt CW. The effect of a microgravity culture environment on growing skin equivalents. Abstract for the Tissue Engineering Society, p. 486, O-82, 1998.
  32. Geldziler B, Ramsamooj R, Catalano E, Doolin EJ, Hewitt CW. Novel high definition 3-D microscopy for evaluating cytopathology and pap smear specimens: 3-D digital image reconstruction and analysis of cell clusters. Acta Cytologica, Vol. 42(5), p. 1299, 1998.
  33. Hewitt CW, Strande L, Geldziler B, Doolin EJ. FAS-mediated pathway of apoptosis in thermally injured bioengineered living skin equivalents. Proceedings of the 31st Annual Meeting of the American Burn Association, 1999.
  34. Tatem LD, Strande L, Patel N, Doolin E, Hewitt C. Protein expression in thermally injured human bioartificial living skin equivalents undergoing cellular inflammation. Proceedings of the 31st Annual Meeting of the American Burn Association, 1999.
  35. Ramsamooj RR, Doolin E, Greenberg G, Catalano E, Hewitt CW. Prospective analysis of Pap Smear classified as ASCUS using high definition 3-dimensional microscopy. 90th Annual Meeting of the American Association for Cancer Research, 1999.
  36. Geldziler B, Strande L, Doolin E, Hewitt CW. The use of multiple oblique light-paths for inverted microscopy: 3-dimensional visualization of bio-engineered tissue. 90th Annual Meeting of the American Association for Cancer Research, 1999.
  37. Hewitt CW, Doolin E, Tran H, Woerner T. Sensitivity of various commercial tetramethyl benzidine (TMB) formulations for immunoassay. The FASEB Journal 13(5), 1999.
  38. Ramsamooj R, Doolin E, Greenberg G, Catalano E, Hewitt CW. Effectiveness of multiple oblique illumination and 3-dimensional microscopy for assessing low-grade lesions in cervical pap smear. The FASEB Journal 13(4), 1999.
  39. Pro E, Geldziler B, Doolin E, Hewitt CW. High definition 3D microscopy based on multiple oblique illumination and digital image analysis of mycology specimens. Proceedings of the 99th General Meeting for the American Society for Microbiology, p 135, 1999.
  40. Hewitt CW, Kain M, Strande L, Puc M, Tran H, DelRossi AJ, Doolin E. A novel rejection model using a microgravity based 3D cell culture system. Cell Transplant Society, Vol 8(2)196, 1999.
  41. Ramsamooj R, Doolin E, Greenberg G, Catalano E, Hewitt C. Multiple oblique illumination and 3-dimensional microscopy for evaluating problematic cervical Pap smears. Acta Cytologica, 43(5), p. 899, 1999.
  42. Hewitt C, Geldziler B, Ramsamooj R, Greenberg G, Doolin E, Kesterson J. A new computerized tomographic microscope emplying confocal emulation for high resolution 3-D image reconstruction of thick Pap smear cell clusters. Acta Cytologica, 43(5), p. 900, 1999.
  43. Kostal M, Strande L, Doolin E, Marra S, DelRossi A. Hewitt C. In Vitro transplantation in a rotational bioreactor using simulated microgravity. Laboratory Investigation, 80(3): 19A, 2000.
  44. Tran JL, Strande LS, Doolin EJ, Hewitt CW. Apoptosis is thermally injured bioengineered human living skin equivalent mediated via annexin-V pathway. The FASEB Journal, 14(4): A197, 2000.
  45. Kann B, Albaugh G, Vemulapalli P, Strande L, Doolin E, Hewitt C. Comparison of adult and neonatal cardiac tissue growth in a micro-gravity based culture system. The FASEB Journal, 14(4): A197, 2000.
  46. Vemulpalli P, Albaugh G, Kann B, Hewitt C, Doolin E, Dean G. Aminophylline mediated increase in bladder compliance in the rat. The FASEB Journal, 14(4), A665, 2000.
  47. Vemulapalli P, Albaugh G, Kann B, Hewitt C, Doolin E, dean G. Dose response determinations of optimal bladder compliance with aminophylline in the rat. The FASEB Journal, 14(4): A665, 2000.
  48. Albaugh G, Vemulapalli G, Kann B, Hewitt C, Doolin E, Dean G. Dampening myogenic autoregulation in human bladder with caffeine. The FASEB Journal, 14(4): A665, 2000.
  49. Tran JL, Strande L, Doolin E, Hewitt C. Apoptosis mediated by FasL/Fas (CD95) in bioengineered skin constructs post thermal injury. Journal of Burn Care Rehabilitation, 21(1)2: S225, 2000.
  50. Kann B, Albaugh G, Strande L, Brimer C, Dean G, Doolin E, Hewitt C. Comparison of pathologic changes in bioengineered skin constructs vs human skin undergoing thermal injury in vitro. Journal Burn Care Rehabilitation, 21(1)2: S227, 2000.
  51. Hewitt CW, Tran LJV, Doolin EJ, Woerner T. The effect of pH on diaminobenzidine (DAB) tissue staining by antibody conjugated horseradish peroxidase (HRP) catalysis. American Society for Microbiology, E-26, pp.58, M ay 2000.
  52. Redden RA, Doolin EJ. Collagen cross linking and cell density had distinct effects on fibroblast mediated contraction of collagen gels. Proceedings of International Society for Bioengineering and the Skin. October 26, 2002.
  53. Redden RA, Doolin EJ. The Role of the Cytoskeleton in Fibroblast-Mediated Contraction of Collagen Gels. Proceeding of the 2003 Engineering Tissue Growth International Conference and Exposition, March 2003.
  54. Redden RA, Doolin EJ. Development of an in vitro tumor model: Growth and adhesion characteristics of neuroblastoma. Proceedings for the Society for Invitro Biology, 2004.
  55. Redden RA, Doolin EJ. Complementary roles of cytoskeletal elements in the contraction of lung fibroblast-populated collagen gels. Midwest Tissue Engineering Consortium, Pittsburgh, Pa., April 2004.
  56. Badillo AT, Redden RA, Doolin EJ, Liechty KW. Mesenchymal stem cell and extracellular matrix interaction: a comparison of fetal versus adult-derived cells. American Academy of Pediatrics National Conference and Exhibition (poster only). Atlanta, GA. October 2006.
  57. Redden RA, Doolin EJ. Characterization of neuroblastoma cells cultured in three-dimensional, microgravity rotary bioreactor: organoid formation and free cell dynamics. 2006 In Vitro Biology Meeting. Minneapolis, MN. June 2006.
  58. Redden, RA, Badillo AT, Doolin EJ, Liechty KW. Comparison of mesenchymal stem cell and dermal fibroblast-mediated contraction of collagen gels: potential differential effects in wound repair. The Wound Healing Society, 16th Annual Meeting and Exhibition. Scottsdale, AZ. May 2006.
  59. Badillo AT, Redden RA, Doolin EJ, Liechty KW. Mesenchymal stem cells contract collagen gels: a basis for direct participation in wound healing. The Wound Healing Society, 16th Annual Meeting and Exhibition. Scottsdale, AZ. May 2006.
  60. Badillo AT, Redden RA, Doolin EJ, Liechty KW. Collagen matrix induced morphologic changes regulate MSC function (poster only). The Wound Healing Society, 16th Annual Meeting and Exhibition. Scottsdale, AZ. May 2006.
  61. Redden RA, Doolin EJ. Donor age, cell density, and complimentary roles of cytoskeletal elements in the contraction of fibroblast-populated collagen gels. 2005 World Congress on In Vitro Biology. Baltimore, MD. June 2005.
  62. Badillo At, Redden RA, Doolin EJ, Liechty KW. Mesenchymal stem cell-mediated contraction of collagen gels: a basis for direct participation in wound healing. American Academy of Pediatrics National Conference and Exhibition (poster only). Washington, D.C. October 2005.
  63. Redden RA, Doolin EJ. Characterization of neuroblastoma organoid growth in a low-shear, microgravity rotary bioreactor and comparison to in vivo tumors. 2004 World Congress on In Vitro Biology. San Francisco, CA. May 2004.
  64. Redden RA, Doolin EJ. Dermal fibroblast-mediated contraction of collagen gels: the influence of donor age, cell concentration, and cytoskeletal elements (poster). Tissue Engineering Society International, 6th Annual Int’l Conference and Exposition. Orlando, FL. December 2003.
  65. Redden RA, Doolin EJ Assay of neuroblastoma cell lines in microgravity: aggregation kinetics and organoid morphology correlate with MYCN expression (poater).
Publications
  1. Doolin EJ and Druek C. Fatal iron intoxication in an adult. J Trauma 20: 518 521, 1980.
  2. Doolin EJ. A subfascial stent for Hesselbach's triangle and difficult fascial closures. Surg Gynecol Obstet. 157: 370 371, 1983.
  3. Richards WO, Doolin EJ, Maginski MP, Moulton AL. Pharmacologic inhibitions of scar contracture of intracardiac prosthetic patches. J Surg Res 37: 33 42, 1984.
  4. Doolin EJ, Ormsbee HS, Hill JL. Experimental intestinal atresia, motility, and physiology. Surg Forum 35: 171 172, 1984.
  5. Doolin EJ, Luck SR, Sherman JV, Raffensperger JL: Emergency lung biopsy: Friend or foe of the immunosuppressed child? J Ped Surg. 21(6): 485 488, 1986.
  6. Doolin EJ, Ormsbee HS, Hill JL. Motility abnormality in intestinal atresia. J Pediatr Surg 22(4): 320 324, 1987.
  7. Doolin EJ, Goldstein H, Kessler B et al. Familial retroperitoneal fibrosis. J Pediatr Surg 22(10): 1092 1094, 1987.
  8. Mure AJ, Unkle DW, Doolin EJ, Ross SE. Blunt aortic trauma following deceleration in a seven year old. Pediatr Emerg Care 6(2): 104-105, 1990.
  9. Sweeney RL, Doolin EJ, Ross SE. Hematuria in injured children: Is emergency radiographic evaluation mandatory? Ann Emerg Med 20(4): 473, 1991.
  10. Doolin EJ, Black CT, Donaldson J, Schwartz D, Raffensperger JG. Rectal manometry computed tomography and functional results of anal atresia surgery. J Pediatr Surg 28(2): 195-198, 1993.
  11. Amin A, Alexander JB, O'Malley KF, Doolin EJ. Blunt abdominal aortic trauma in children. J Trauma 34(2): 293-296, 1993.
  12. Doolin EJ. Esophageal stricture: An uncommon complication of foreign bodies. Ann Otol Rhinol Laryngol 102(11): 863-866, 1993.
  13. Doolin EJ. Composite reconstruction of the esophagus and hypopharynx after severe caustic injury. Ann Otol Rhinol Laryngol 103(1): 36-40, 1994.
  14. Doolin EJ. Airway reconstruction in children. Current Surgery 51(1): 5-9, 1994.
  15. Heether J, Whalen TV, Doolin EJ. Follow up of complex unresectable lymphangiomas. American Surgeon 60(11):840-841, 1994.
  16. Doolin EJ, Strande L. Calibration of endoscopic images. Ann Otol Rhinol Laryngol 104(1): 19-23, 1995.
  17. Stein SC, Doolin EJ. Management of minor closed head injury in children and adolescents. Pediatr Surg Int 10: 465-471, 1995.
  18. Puglisi RN, Whalen TV, Doolin, EJ. Computer analyzed histology of ischemic injury to the gut. J Pediatr Surg 30(6):839-844, 1995.
  19. Hewitt CW, Englesbe MJ, Tatem LD, Strande LF, Doolin EJ, Dalsey RM, DeLong WG. Graft versus host disease in extremity transplantation: Digital image analysis of bone marrow in situ. Ann Plast Surg 35(1): 108-112, 1995.
  20. Doolin EJ , Strande L, Attorri RJ. Morphometry and histochemistry of pulmonary arteries in a hypoplastic lung model. J Surg Res 59: 191-197, 1995.
  21. Santos M, Strande L, Doolin EJ. Airway measurement using morphometric analysis. Ann Otol Rhinol Laryngol. 104(11): 835-838, 1995.
  22. Puglisi RN, Doolin EJ, Hewitt CW. Morphometric analysis of rat renal allograft tolerance by computerized digital image processing. Transplant Proc 27(1):555-556, 1995.
  23. Puglisi RN, Strande, LF, Hewitt, CW, Whalen TV, Doolin EJ. The effect of cyclosporin in gut ischemic injury: A computerized morphometric and enzymatic analysis. J Pediatr Surg. 31(2) 319-322, 1996.
  24. Santos MC, Strande L, Doolin EJ. Oligohydramnios does not alter myometrial response to cholinergic stimuli. Surg Forum, Vol. XLV1.
  25. Hewitt C, Doolin E, Achauer B, Foley ST. Burn research without animals. Good Medicine 5(2): 9-10, 1996.
  26. Strande LF, Foley ST, Doolin EJ, Hewitt CW. In vitro bioartificial skin culture model of tissue rejection and inflammatory/immune mechanisms. Transplant Proc 29(4): 2118-2119, 1997.
  27. Hewitt C W, Strande L, Santos M, Goodman M, Tarnoff M, Zaontz MR, DelRossi AJ, Doolin ER. Rat renal allograft tolerance is associated with local TGF-? and absence of IL-2r expression within chimeric immunocytic foci. Transplant Proc 29(4): 2183-2184, 1997.
  28. Goodman MD, Tarnoff ME, Strande LF, Tatem L, Kain MS, Doolin EJ, DelRossi AJ, Hewitt CW. The relationship between in situ chimerism, local TGF-? and IL-2r expression in rat allograft tolerance. Surgical Forum, 48: 508-509, 1997.
  29. Hewitt C, Goodman M, Tarnoff M, Ramsamooj R, Doolin E. Use of multiple oblique illumination and 3-D microscopy in cytopathology. Biomedical Products Magazine, 7: 138-139, 1997.
  30. Doolin EJ, Strande LF, Tsuno K, Santos MC. ? -Aminopropionitrile decreases collagen III deposition in experimental model of subglottic stenosis. Ann Otol Rhinol & Otolaryngol, accepted for publication.
  31. Doolin EJ, Tsuno K, Strande LF, Santos MC. Pharmacologic inhibition of collagen in an experimental model of subglottic expression within chimeric immunocytic foci. Ann Otol Rhinol Laryngol, 107(4): 275-279, 1999.
  32. Ramsamooj R, Strande L, Kain M, Doolin EJ, Hewitt CW. A novel in vitro model for xenorejection and immune mechanisms using bioengineered living skin equivalents. Transplant Proc, 30(4):1087-1088, 1998.
  33. Hewitt CW, Tarnoff M, Goodman M, Ramsamooj R, Chin V, Doolin EJ. Use of 3-D microscopy with multiple oblique illumination in evaluating cytopathology preparations. Anal Quant Cytol Histol, 21(2): p. 139.142, 1999.
  34. Doolin EJ, Strande L, Chen MK, Kain M, Hewitt CW. The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model. J Burn Care Rehabil, 20(5): 374-376, 1999.
  35. Chen MK, Strande L, Kain M, Whalen TV, Doolin EJ. Induction of apoptosis in a neuroblastoma and hepatocyte coculture model. J Surg Res, 78(2):123-130, 1999.
  36. Chen MK, Strande LF, Beierle EA, Kain MS, Geldziler BD, Doolin EJ. FAS-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model. J Surg Res, 84(1): 82-87, 1999.
  37. Doolin EJ, Browne AM, DiScala C. Pediatric Trauma Center Criteria: An outcome analysis. J Ped Surg, 34(5): 885-9, 1999, discussion 889-90.
  38. Suzuki H, Hewitt CW, Tran H, Puc MM, Patel N, Matthews M, Dalsey R, Doolin EJ, DelRossi AJ. Composite tissue/vascularized bone marrow transplantation: A hierarchy of tissue tolergenicity. Graft 2(3), 111-115, 1999.
  39. Ramsamooj R, Greenberg G, Doolin EJ, Hewitt CW. Three dimensional microscopy for evaluating cytology specimens: A possible Apap@ smear. Focus, 6(2): 6, 1999.
  40. Doolin EJ, Geldziler B, Strande L, Kain M, Hewitt CW. The effects of microgravity on growing cultured skin constructs. Tissue Engineering, 5(6): 573-582, 1999.
  41. Puc MM, Chrzanowski FA, Tran H, Geldziler B, Martucci M, Doolin EJ, Hewitt CW. Multiple oblique illumination and high definition microscopy for breast fine needle aspirates. J Invest Surg , In Press.
  42. Hewitt CW, Geldziler B, Ramsamooj R, Greenberg G, Doolin E. High definition microscopy based on multiple oblique illumination and 3-dimensional image reconstruction for cytopathology and pap smear analysis. Anal Quant Cytol Histol, 21(2):139-142, April 1999.
  43. Suzuki H, Patel N, Matthews M, DelRossi AJ, Doolin EJ and Hewitt CW. Vascularized bone marrow transplantation: A new surgical approach utilizing isolated femoral bone/bone marrow. J Surg Res, 89, 176-183, 2000.
  44. Doolin EJ, Strande LF, Sheng X. Hewitt CW. Engineering a composite neotrachea with surgical adhesives: J Pediatric Surg.:37 (7):1034-7, July 2002.
  45. Beierle EA, Chen MK, Whalen TV, Doolin EJ. Free fluid on abdominal computed tomography scan after blunt trauma does not mandate exploratory laparotomy in children: J Pediatric Surg.: 35 (6):990-2:discussion 993, June 2000.
  46. Ramsamooj R, Doolin EJ, Greenberg G, Catalano E, Hewitt CW. Real-time, high-definition, three-dimensional microscopy for evaluating problematic cervical Papanicolaou smears classified as atypical squamous cells of undetermined significance: Cancer 25:96 (3):181-6, June 2002.
  47. Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW, Doolin EJ. Computer-assisted stereology: Point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning 25:3744, 2003.
  48. Redden RA, Doolin EJ. Collagen crosslinking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Research and Technology. 2003:9: 290-293.
  49. Redden RA, Doolin EJ. (2006) Complementary roles of microtubules and microfilaments in the lung fibroblast-mediated contraction of collagen gels: dynamics and the influence of cell density. In Vitro Cell Dev Biol Anim. 42:70-74.
  50. Danzer E, Kiddoo DA, Redden RA, Robinson L, Radu A, Zderic SA, Doolin EJ, Adzick NS, Flake AW. Structural and Functional Characterization of Bladder Smooth Muscle in Fetal Rats with Retinoic Acid Induced Myelomeningocele. Am J Physiol Renal Physiol. 2007 Jan:292(1):F197-206. Epub 2006 Aug 29.
  51. Badillo AT, Redden RA, Zhang L, Doolin EJ, Liechty KW. Treatment of Diabetic Wounds with Fetal Murine Mesenchymal stromal cells enhances wound closure. Cell Tissue Res. 2007 Aug;329(2):301-11. Epub 2007 Apr 24.
Review Articles
  1. Sweeney R, Doolin EJ: Head and Neck Trauma in Children. In: Topics in Emergency Medicine, Ross SR, ed; pp. 78-84, 1991.
  2. Ramsamooj R, Greenberg G, Doolin E, Hewitt C. Three Dimensional Microscopy for Evaluating Cytology Specimens. A Possible APap≡ Advantage. In: Focus, Papanicolaou Society of Cytopathology, Vol 6 (2); pp. 6, 1999.
Books and Chapters
  1. Marchildon MB, Doolin EJ. Birth Injuries. In: Management of Pediatric Trauma, William Buntain, ed; Saunders, Philadelphia, 1994.
  2. Sacchetti AD, Betler R, Doolin EJ. Pediatric trauma in: trauma management, an emergency medicine approach. ed; Ferrera, Colucciello, Marx Verdile, Gibbs Mosby stionis 2001.
  3. Doolin EJ. Tracheomalacia. In Surgical Directives: Pediatric Surgery ed; Peter Mattei, MD. Lippincott, Williams and Wilkins, Philadelphia 2002
  4. Doolin EJ. Bowel Management for Patients with Myelodysplasia. In Chen MK, Martin RF (eds) Surgical Clinics of North Amercia. Philadelphia: Elsevier Saunders, 2006
  5. Doolin EJ. Vagina: Disease and Treatment. In: Fundamentals of Pediatric Surgery, ed; Peter Mattei, Springer Science + Business Media, INC, 233 Spring Street, New York, NY 10013-1578.

Dr. Edward Doolin

 
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