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Alan W. Flake, M.D.
Pediatric Surgery

 
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Administrative Office:
Children’s Hospital of Philadelphia
Abramson Research Center, Rm. 1116B
3615 Civic Center Blvd.
Philadelphia, PA 19104
Administrative Assistant: Colleen Corcoran
Administrative Telephone: 215-590-3671
Administrative Fax: 215-590-3324
Patient Appointments: 215-590-2744

Clinical Offices:
Childrenís Hospital of Philadelphia
Abramson Research Center, Rm. 1102D
3516 Civic Center Blvd.
Philadelphia, PA 19104
Clinical Telephone: 215-590-2744
Clinical Fax: 215-590-3240
Patient Appointments: 215-590-2744

Contact Information (internal use only)

flake@email.chop.edu

Link to Children's Hospital of Philadelphia

 

Alan W. Flake, M.D. is Director of the Children’s Institute for Surgical Science and the Pediatric Surgery Residency Training Program Director at the Children’s Hospital of Philadelphia and is a Professor of Surgery and Obstetrics and Gynecology at the University of Pennsylvania School of Medicine. He maintains an active surgical practice in pediatric general, and thoracic surgery and has a focused clinical and research interest in fetal surgery. He is director of an active research laboratory located on the 11th floor of the Abramson Research Building investigating fetal stem cell and gene therapy, as well as prenatal correction of specific fetal surgical anomalies.

 
Faculty Appointments
1990 - 1994  Assistant Professor of Surgery and Pediatrics, Division of Pediatric Surgery
University of California, San Francisco
 
1994 - 1996 Associate Professor of Surgery and Obstetrics and Gynecology
Wayne State University, Children’s Hospital of Michigan, Detroit, Michigan  
 
1994 - 1996 Director of Fetal Surgery, Children’s Hospital of Michigan
 
1996 - 2001 Associate Professor of Surgery and Obstetrics, and Gynecology
University of Pennsylvania, Ruth and Tristram C. Colket, Jr. Professor of Pediatric Surgery, Children's Hospital of Philadelphia
 
1996 - present Director of the Children’s Institute for Surgical Science
re-named the Center for Fetal Research (2006)
Stokes Research Institute, Abramson Pediatric Research Center
 
1996 - present Senior Member, Joseph Stokes, Jr. Research Institute
 
1997 - present Full Member, Institute of Human Gene Therapy, University of Pennsylvania
 
1998 - present Pediatric Surgery Fellowship Training Director, Children’s Hospital of Philadelphia
 
2002- present Professor of Surgery and Obstetrics, and Gynecology, University of Pennsylvania
 
Hospital and Administrative Appointments
1990 - 1994  Active Clinical Staff - University California
San  Francisco Hospitals
San Francisco, California
 
1990 - 1994 Active Clinical Staff, California Pacific Medical Center
California and  Pacific Campuses
San Francisco, California
 
1990 - 1994 Courtesy Staff, Kaiser Permanente Hospital
San Francisco, California     
 
1994 - 1996 Active Clinical Staff, Children's Hospital of Michigan
Director of Fetal Surgery Children's Hospital of  Michigan
Detroit, Michigan
 
1994 - 1996 Active Clinical Staff, Henry Ford Hospital
Detroit, Michigan
 
1994 - 1996  Active Clinical Staff, Hutzel Hospital, Detroit Medical Center
Detroit,  Michigan
 
1994 - 1996 Active Clinical Staff, St. John's Hospital
Detroit, Michigan
 
1996 - present Active Clinical Staff, Children’s Hospital of  Philadelphia
Philadelphia, Pennsylvania
 
1997 - present Pediatric Surgery Fellowship Training Director
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
1997 - present Active Clinical Staff, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1997 - present Courtesy Staff, Department of Surgery, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
1997 - present Consulting Staff, Department of Surgery, The Chester County Hospital
West Chester, Pennsylvania
 
Education/Training
1973 H.S., Taipei American School, Taipei, Taiwan
 
1977 B.S., University of Arkansas, Fayetteville    
 
1981 M.D., University of Arkansas for Medical Sciences, Little Rock
 
Postgraduate Training and Fellowship Appointments
1981 - 1982 Intern in Surgery, University of California, San Francisco
 
1982 - 1984 General Surgery PGY 2-3, University of California, San Francisco
 
1984 - 1986 U.C.S.F. Fetal Biology and Therapy Research Fellowship
 
1986 - 1988 General Surgery PGY 4-5, University of California, San Francisco
 
1988 - 1990 Pediatric Surgery Fellowship, Children’s Hospital Medical Center, Cincinnati, Ohio
 
Memberships/Societies
 
National or International Societies
1986 - present International Fetal Medicine and Surgery Society
   
1986 - 1989 Candidate Group American College of Surgeons
   
1989 - present Extracorporeal Life Support Organization
   
1990 - present American Association for the Advancement of Science
   
1991 - present Associate for Academic Surgery
   
1992 -1994 Councilman Association for Academic Surgery
   
1991 - 1993 Associate Fellow American College of Surgeons
   
1991 - present Cell Transplant Society
   
1993 - present American Pediatric Surgical Association
   
1993 - present    Fellow American College of Surgeons
   
1996 - present American Academy of Pediatrics, Surgical Section
   
1996 - present International Society for Prenatal Diagnosis
   
1997 - present American Society of Gene and Cellular Therapy
   
1998 - present American Society of Hematology
   
1999 - present International Society of Experimental Hematology
   
2005 - present American Society for Blood and Marrow Transplantation
   
2011 - present International Pediatric Endosurgery Group
   
Local Societies
1988 - present Howard C. Naffziger Surgical Society
   
1992 - 1996 San Francisco Surgical Society
   
1995 - 1998 Wayne State Medical Society
   
1995 - 1998 Michigan State Medical Society
   
1997 - present Philadelphia Perinatal Society
   
1997 - present John Morgan Society
   
1998 - present American College of Surgeons - Philadelphia Chapter
 
Research
 
 
 
 
 
 
 
 
 
 
Publications
 
Bibliography
  1. Adzick NS, Harrison MR, Flake AW, LaBerge JM:  Development of a fetal renal function test using endogenous creatinine clearance.  Journal of Pediatric  Surgery 20:602-607, 1985.
  2. Adzick NS, Harrison MR, Flake AW, deLorimier AA:  Urinary extravasation in the fetus with obstructive uropathy.  Journal of Pediatric Surgery 20:608-615, 1985.
  3. Adzick NS, Harrison MR, Flake AW, Glick PL, Bottles K:  Automatic uterine stapling devices in fetal surgery: Experience in a primate model.  Surgical Forum XXXVI:479-81, 1985.
  4. Adzick NS, Harrison MR, Glick PL, Anderson J, Villa RL, Flake AW, Laberge JM:  Fetal  surgery in the primate. III. maternal outcome after surgery.  Journal of Pediatric Surgery 21:477-480, 1986.
  5. Flake AW, Harrison MR, Adzick NS, LaBerge JM, Warsof SL:  Fetal sacrococcygeal teratoma. Journal of Pediatric Surgery 21:563-66, 1986.
  6. Flake AW, LaBerge JM, Adzick NS, Hill AC, Harrison MR:  Auxiliary transplantation of the fetal liver. I. Development of a sheep model.  Journal of Pediatric Surgery 21:515-520, 1986.
  7. Flake AW, Villa-Troyer RL, Adzick NS, Harrison MR:  Trans-amniotic fetal feeding. III. The effect of nutrient infusion on intrauterine growth retardation. Journal of Pediatric Surgery 21:481-484, 1986.
  8. Flake AW, Harrison MR, Adzick NS, Zanjani ED:  Transplantation of fetal hematopoietic stem cells in utero: The creation of hematopoietic chimeras.  Science 233(4765):776-8, 1986.
  9. Flake AW, Harrison MR, Adzick NS, Sauer L, deLorimier AA:  Ureteropelvic junction obstruction in the fetus. Journal of Pediatric Surgery 21:1058-63, 1986.
  10. Sauer L, Glick PL, Adzick NS, Flake AW, Harrison MR:  Compensatory renal growth following nephrectomy in fetal lambs.  Surgical Forum XXXVII:648-50, 1986.
  11. Adzick NS, Hu LM, Davies P, Flake AW, Reid L, Harrison MR:  Compensatory lung growth after pneumonectomy in fetal lambs: A morphometric study.  Surgical Forum XXXVII:309-11, 1986.
  12. Kantoff PW, Gillio A, McLachlin JR, Flake AW, Eglitis MA, Moen R, Karlsson S, Kohn DB, Karson E, Zweibel JA:  Retroviral-mediated gene transfer into hematopoietic cells.Transactions of the Association of American Physicians 99:92-102, 1986.
  13. Sauer L, Harrison MR, Flake AW:  Does an expanding fetal abdominal mass produce pulmonary hypoplasia.  Journal of Pediatric Surgery 22:508-12, 1987.
  14. Harrison MR, Golbus MS, Filly RA, Anderson RL, Flake AW, Rosen M, Huff RW:  Fetal hydronephrosis: Selection and surgical repair.  Journal of Pediatric Surgery 22:556-8, 1987.
  15. Flake AW, Harrison MR, Sauer L, Adzick NS, Krummel TM, LaBerge JM:  Auxiliary transplantation of the fetal liver. II. functional evaluation of an intraabdominal model. Journal of Pediatric Surgery 22:559-65, 1987.
  16. Sauer L, Harrison Mr, Flake AW, Heyman MB, Ring EJ;   Long-term percutaneous biliary drainage in an infant with hemangioendothelioma.  Journal of Pediatric Surgery 22:606-8, 1987.
  17. Flake AW, Villa RL, Adzick NS, Harrison MR:  Trans-amniotic fetal feeding. II. A model of intrauterine growth retardation.  Journal of Pediatric Surgery 22:816-19, 1987.
  18. Flake AW, Harrison MR, Adzick NS, Zanjani ED:  Erythropoietin production by the fetal liver in the adult environment.  Blood 70:542-5, 1987.
  19. Kuhlmann RS, Warsof SL, Levy DL, Flake AW, Harrison MR.  Fetal sacrococcygeal teratoma. Fetal Therapy 2:95-100, 1987.
  20. Kantoff PW, Flake AW, Eglitis MA, Scharf S, Bond S, Gilboa E, Erlich H, Harrison MR, Zanjani ED, Anderson WF:  In utero gene transfer and expression: A sheep transplantation model. Blood 73:1066-1073, 1988.
  21. Verrier ED, Crombleholme TM, Sauer L,  Longaker M, Langer JC, Flake AW,  Dae M, Brem H, Harrison MR:  Neonatal model of heterotopic heart transplantation in pigs.  Journal of Thoracic and Cardiovascular Surgery 98:127-35, 1989.
  22. Bond SJ, Harrison MR, Slotnick RN, Anderson J, Flake AW, Adzick NS:  Cesarean delivery and hysterotomy using an absorbable stapling device.  Obstetrics and Gynecology 74:25-8, 1989.
  23. Bond SJ, Harrison MR, Schmidt KG, Silverman NH, Flake AW, Slotnick NR, Anderson RL, Warsof SL, Dyson DC.  Death due to high output cardiac failure in fetal sacrococcygeal teratoma. Journal of Pediatric Surgery 25:1287-1291, 1990.
  24. Nelson JM, Krummel TM, Haynes JH, Flood LC, Sauer L, Flake AW, Harrison MR: Operative techniques in the fetal rabbit.  Journal of Investigative Surgery 3:393-398, 1991.
  25. Ryckman FC, Flake AW, Fisher RA, Tchervenkov JI, Pedersen SH, Balistreri WF:  Segmental orthotopic hepatic transplantation as a means to improve patient survival and diminish waiting list  mortality.  Journal of Pediatric Surgery 26:422-428, 1991.
  26. Plowden JS, Kimball TR, Bensky A, Savani R, Flake AW, Warner BW, von Allmen D, Ryckman FC: The use of extracorporeal membrane oxygenation in critically ill neonates with Ebstein's anomaly.  American Heart Journal 121: 619-622, 1991.
  27. Flake AW, Shopene C, Zeigler MM:  Anti-reflux gastrointestinal surgery in the neurologically handicapped child.  Pediatric Surgery International 6:92-97, 1991.
  28. Duncan BW, Harrison MR, Flake AW, Bethel CI, Bigler ME, Roncorolo MG:  Immune response in hematopoietic chimeric rhesus monkeys. Surgical Forum XLII:373-375, 1991.
  29. Pallavicini  MG, Flake AW, Bethel C, Langlois R, Madden D, Duncan BW, Haendel S, Montoya T: Creation of human-mouse xenogeneic chimeras by the in-utero transplantation of hemopoietic cells. Transplantation Proceedings 24:542-543, 1991.
  30. Zanjani ED, Pallavicini MG, Ascencao JL, Flake AW, Resima M, MacKintosh FR, Langlois R, Stutes D, Harrison MR, and Tavassoli M.   Engraftment and long term expression of human fetal hemopoietic stem cells in sheep following transplantation in-utero.  Journal of Clinical Investigation 89:1178-1188, 1992.
  31. Jennings RW, Flake AW, Mussan G, Harrison MR, Adzick NS, Pellegrini CA:  A novel endoscopic transgastric fundoplication procedure for gastroesophageal reflux. Journal of Laparoendoscopic  Surgery 2:207-213, 1992.
  32. von Allmen D, Babcock D, Matsumoto J, Flake AW, Warner BW, Stevenson RJ, Ryckman FC.  The predictive value of head ultrasound in the ECMO candidate.  Journal of Pediatric Surgery 27:36-39, 1992.
  33. Hedrick MH, Jennings RW, MacGillivray TE, Flake AW, Lorenz HP, Estes JM, Roberts L, Adzick NS, Harrison MR:  Endoscopic catheterization of placental vessels for chronic fetal vascular access.  Surgical Forum XLIII:504-5, 1992.
  34. Zanjani ED, Pallavacini MG, Ascensao JL, Flake AW, Harrison MR, Tavassoli M.:  Human-ovine xenogeneic transplantation of stem cells in-utero. Bone Marrow Transplantation 9 Suppl 1:86-9, 1992.
  35. Zanjani ED, Ascensao JL, Flake AW, Harrison MR, Tavassoli M: The fetus as an optimal donor and  recipient of hemopoietic stem cells.  Bone Marrow Transplantation 10 Suppl 1:107-14, 1992.
  36. Rice HE, Hedrick MH, Flake AW, Donegan E, Harrison MR:  Bacterial and fungal contamination of  human fetal liver collected transvaginally for hematopoietic stem cell transplantation.  Fetal Diagnosis and Therapy 8:74-78, 1993.
  37. Hedrick MH, Rice HE, Zanjani ED, Sachs DH, Flake AW.  Creation of pig-sheep xenogeneic chimerism by the in-utero transplantation of hematopoietic stem cells.  Transplantation Science 3:23-26, 1993.
  38. Adzick NS, Harrison MR, Flake AW, Howell LJ, Golbus MS, Filly RA, and the UCSF Fetal Treatment  Program:  Fetal surgery for cystic adenomatoid malformation of the lung. Journal of Pediatric Surgery 28:806-812, 1993.
  39. Harrison MR, Adzick NS, Flake AW, Jennings RW:  The CDH two-step: a dance of necessity.  Journal of Pediatric Surgery 28:813-816, 1993.
  40. Rice HE, Flake AW, Hedrick MH, Zanjani ED, Harrison MR:  Effect of xenogeneic chimerism in a human/sheep model on natural antibody.  Journal of Surgical Research 54:355-359, 1993.
  41. Rice HE, Hendrick MH, Bealer JF, Zanjani ED, Harrison MR, Flake AW:  Placental vessel catheterization: A new technique of chronic intravenous access in fetal sheep.  Surgical Forum XLIV:644-646, 1993.
  42. Hedrick MH, Estes JM, Sullivan KM, Bealer JF, Flake AW, Adzick NS, Harrison MR: Plug the lung until it grows (PLUG):  A new method to treat congenital diaphragmatic hernia in-utero. Surgical Forum XLIV:644-646, 1993.
  43. Harrison MR, Adzick NS, Flake AW and members of the Fetal Treatment Program: Correction of             congenital diaphragmatic hernia in-utero: VI hard earned lessons.  Journal of Pediatric Surgery 28:1411-1418 1993.
  44. Hedrick MH, Jennings RW, MacGillivray TE, Rice HE, Flake AW, Adzick NS, Harrison MR.  Chronic fetal vascular access.  Lancet 342:1086-1087, 1993.
  45. Srour, EF, Zanjani ED, Cornetta K, Traycoff CM, Flake AW, Hedrick M, Brandt JE Leemhuis T, Hoffman R:  Persistence of human multilineage self-renewing lymphohematopoietic stem cells in chimeric sheep.  Blood 82:3333-3342, 1993.
  46. Bealer JF, Natuzzi ES, Buscher C, Flake AW, adzick NS, Harrison MR:  Nitric oxide synthase is deficient in the aganglionic colon from patients with hirschsprung's disease.  Pediatrics  93:647-651, 1994.
  47. Hedrick MH, Martinez M, Filly RA, Flake AW, Adzick NS, Harrison MR:  Congenital high airway obstruction syndrome (CHAOS): A potential for perinatal intervention.  Journal of Pediatric Surgery 29:271-274, 1994.
  48. Hedrick MH, Rice HE, MacGillvray TE, Bealer JF, Zanjani ED, Flake AW:  Hematopoietic chimerism achieved by in-utero hematopoietic stem cell injection does not induce donor specific tolerance or renal allografts in sheep.  Transplantation 58:110-111, 1994.
  49. Zanjani ED, Flake AW, Rice HE, Hedrick MH, Tavassoli M: Long-term hematopoietic repopulating ability of xenogenic transplanted human fetal liver stem cell (HSC) in sheep.  Journal of Clinical Investigation 93:1051-1055, 1994.
  50. Hedrick MH, Estes JM, Sullivan KM, Bealer JF, Kitterman JA, Flake AW, Adzick NS, Harrison MR:  Plug the lung unit it grows (PLUG): A new method to treat congenital diaphragmatic hernia in utero. Journal of Pediatric Surgery 29:612-617, 1994.
  51. Rice HE, Flake AW, Hori T, Galy A, Verhoogen RH:  Massive thymic hyperplasia: characterization of a rare mediastinal mass.  Journal of Pediatric Surgery  29:1561-1564, 1994.
  52. Bealer JF, Natuzzi ES, Flake AW, Adzick NS, Harrison MR:  The effect of nitric  oxide on the colonic smooth muscle of patients with hirschsprung's disease.  Journal of Pediatric Surgery 29:1025-1029, 1994.
  53. Sullivan KM, Hawgood S, Flake AW, Harrison MR, Adzick NS:  Amniotic fluid phospholipid analysis in the congenital diaphragmatic hernia fetus.  Journal of Pediatric Surgery 29:1020-1024, 1994.
  54. Zanjani ED, Silva MRG, Flake AW:   Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras.  Blood Cells 20:331-340, 1994.
  55. Rice HE, Emani VR, Skarsgard ER, Knazek RA, Zanjani ED, Flake AW, Harrison MR:   Human fetal liver hematopoietic cell expansion with a novel biorector system. Transplantation Proceedings 26:3338-3339, 1994.
  56. Rice HE, Hendrick MH, Flake AW:   In-utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice.  Transplantation Proceedings 26:126-128, 1995.
  57. Bealer JF, Skarsgard ED, Hedrick MH, Meuli M, VanderWall KJ, Flake AW, Adzick NS, Harrison MR:   The PLUG (plug the lung until it grows) odyssey: adventures in experimental fetal tracheal occlusion.  Journal of Pediatric Surgery 30:361-365,  1995.
  58. Rice HE, Skarsgard ED, Emani VR, Harrison MR, Zanjani ED, Flake AW:   An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells.  Transplantation Proceedings 26:3352-3, 1995.
  59. Bethel CAI, Steinkirchner T, Zanjani ED, Flake AW:  The stromal microenvironment of human fetal hematopoiesis; in vitro morphologic studies.  Pathobiology 62:99-103, 1995.
  60. Flake AW, Hendrick MH, Rice HE, Tavassoli M, Zanjani ED:  Enhancement of human hematopoieses by mast cell growth factor in human-sheep chimeras created by the in-utero transplantation of human fetal hematopoietic cells.  Experimental Hematology 23:252-257, 1995.
  61. Johnson MP, Corsi P, Bradford W, Hume RF, Smith C, Flake AW, Quereshi F, Evans MI.: Sequential fetal urine analysis provides greater precision in the evaluation of fetal obstructive uropathy.  American Journal of Obstetrics and Gynecology 173:59-65, 1995.
  62. Kawashima I,  Zanjani ED,  Almaida-Porada G,  Flake AW,  Zeng H,  Ogawa M. CD34+ human marrow cells that express low levels of Kit protein are enriched for  long-term marrow-engrafting cells. Blood  87:4136-42, 1996
  63. Harrison MR, Adzick NS, Flake AW, VanderWall KJ, Bealer JF, Howell LJ, Farrell JA, Filly RA, Rosen MA, Sola A, Goldberg JD. Response of the hypoplastic lung to tracheal occlusion in fetuses with diaphragmatic hernia. Journal of Pediatric Surgery 31:339-348,1996
  64. Flake AW, Roncarolo M-G, Puck JM, Ameida-Porada G, Evans MI, Johnson MP, Abella EM, Harrison DD, Zanjani ED.  Treatment of X-linked Severe Combined Immunodeficiency(X-SCID) by the in utero transplantation of paternal bone marrow. New England Journal of Medicine 335:1806-1810, 1996
  65. Flake AW, Zanjani ED. In Utero Hematopoietic Stem Cell Transplantation: A Status Report. Journal of the American Medical Association 278:932-937, 1997
  66. Mason RJ, Filipi CJ, DeMeester TR, Peters JH, Lund RJ, Flake AW, Hinder RA, Smyrk TC, Bremner CG, Thompson S. A new intraluminal antigastroesophageal reflux procedure in baboons. Gastrointestinal Endoscopy. 45:283-90, 1997.
  67. Yang EY, Cass DL, Sylvester KG, Flake AW, Wilson JM, Adzick NS. Liver-dIrected fetal gene therapy using recombinant adenoviral vectors: Successful readministration in mid-gestation sheep fetuses. Surgical Forum, XLVIII:464-467, 1997
  68. Cass DL, Yang EY, Liechty KW, Quinn TM, Crombleholme TM, Flake AW, Adzick NS. Increased cell proliferation and decreased apoptosis in congenital cystic adenomatoid malformation: Insights into pathogenesis. Surgical Forum XLVIII:659-661,1997
  69. Quinn TM, Kirsch AJ, Zderic SA, Duckett JW, Howard P, Flake AW, Adzick NS, Canning DA, Hubbard A, Snyder HM, Macarak EJ. Renal effects of partial bladder outlet obstruction in the fetal lamb. Surgical Forum XLVIII:764-766, 1997
  70. Sylvester KG, Rasanen J, Kitano Y, Flake AW, Crombleholme TC, Adzick NS. Fetal tracheal occlusion reverses high vascular impedance in diaphragmatic hernia. Surgical Forum XLVIII:649-651, 1997
  71. Liechty KW, Crombleholme TM. Flake AW, Morgan MA, Kurth CD, Hubbard AM, Adzick NS: Intrapartum airway management for giant fetal neck masses: The EXIT procedure (Ex Utero IntrapartumTreatment).  American  Journal of Obstetrics and Gynecology 177:870-874, 1997.
  72. Zanjani ED, Almeida-Porada G, , Livingston AG, Flake AW, Ogawa M. Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression including giving rise to CD34+ cells. Experimental Hematology, 26:353-360, 1998
  73. Flake AW, Zanjani ED. In Utero Transplantation for Thalassemia. Annals of the New York Academy of Sciences 850:300-311, 1998
  74. Sylvester KG, Rasanen J, Kitano Y, Flake AW, Crombleholme TC, Adzick NS. Tracheal occlusion reverses the high vascular impedance to flow in the fetal pulmonary circulation and normalizes it’s physiologic response to oxygen at term. Journal of Pediatric Surgery, 33:1071-1076,1998
  75. Cass DL, Yang EY, Liechty KW, Quinn TM, Crombleholme TM, Flake AW, Adzick NS. Increased cell proliferation and decreased apoptosis in congenital cystic adenomatoid malformation: Insights into pathogenesis. Journal of Pediatric Surgery, 33:1043-1047, 1998
  76. Leahey AM, Shears GJ, Smith CA, Flake AW, Sullivan KE. Successful use of extracorporeal membrane oxygenation (ECMO) as a bridge to reconstitution following BMT for SCID. Bone Marrow Transplantation 21:839-840, 1998
  77. Kim HB, Shaaban AF, Yang EY, Liechty KW, Flake AW. Microchimerism and tolerance after in utero bone marrow transplantation in mice. Journal of Surgical Research 77:1-5, 1998.
  78. Porada CD, Tran N, Eglitis M, Moen RC, Troutman L, Flake AW, Zhao Y, Anderson WF, Zanjani ED. In utero gene therapy: Transfer and long term expression of the bacterial neoR gene in sheep following direct injection of retroviral vectors into pre-immune fetuses. Human Gene Therapy 9:1571, 1998
  79. Shaaban AF, Kim HB, Milner R, Fichter C. Flake AW. Pretreatment of prenatally transplanted allogeneic marrow with VEGF and SCF delays allograft rejection in chimeric mice. Surgical Forum XLIX:380-81, 1998.
  80. Milner R, Kim HB, Shaaban AF, Fichter C, Scully M, Asakura T, Flake AW. In utero HSC transplantation in mice transgenic for human hemoglobinopathy - Selective advantage for donor red cells. Surgical Forum XLIX:471-2, 1998
  81. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. Surgical Forum XLIX:353-4, 1998
  82. Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Fetal intramuscular delivery of recombinant adenovirus results in persistent postnatal transgene expression in both muscle and liver. Surgical Forum XLIX:368-9, 1998
  83. Lovvorn HN, Crombleholme TM, Drott H, Flake AW, Adzick NS. Maternal colloid osmotic pressure after fetal surgery. Surgical Forum XLIX:481-2, 1998
  84. Kitano Y, von Allmen D, Yang EY, Quinn TM, Kanai M, Adzick NS, Flake AW. Prenatal tracheal occlusion enhances lung growth in the nitrofen induced CDH model. Surgical Forum XLIX:587-9,1998
  85. Noorily MJ, Farmer DL, Flake AW. The association of complete laryngotracheoesophageal cleft with left lung agenesis: Pathophysiologic clues provided by an experiment of nature. Journal of Pediatric Surgery 33:1546-1549, 1998
  86. Adzick NS, Harrison MR, Crombleholme TM, Flake AW, Howell LJ. Fetal lung lesions: Management and outcome. American Journal of Obstetrics and Gynecology, 179:884-889,  1998
  87. Kitano Y, Yang EY, von Allmen D, Quinn TM, Adzick NS, Flake AW. Tracheal occlusion in the fetal rat: A new experimental model for the study of accelerated lung growth. Journal of Pediatric Surgery 33:1741-1745,1998
  88. Adzick NS, Sutton LN, Crombleholme TM, Flake AW. Successful fetal surgery for spina bifida.  Lancet  352(No. 9141):1675-1676, 1998
  89. Milner R, Shaaban AF, Kim HB, Fichter C, Flake AW. Postnatal booster injections increase engraftment after in utero stem cell transplantation. Journal of Surgical Research. 83, 44-47, 1999.
  90. Liechty KW, Crombleholme TM, Weiner S, Bernick B, Flake AW, Adzick NS. Use of the ex utero intrapartum treatment procedure for a large fetal neck mass in a twin gestation. Obstetrics and Gynecology 93:824-825, 1999
  91. Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus. Journal of Pediatric Surgery 34:766-773, 1999
  92. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. Journal of Pediatric Surgery 34:726-730, 1999
  93. Quinn TM, Sylvester KG, Kitano Y, Kitano Y, Jarrett BP, Sablich TJ, Adzick NS, Flake AW. TGF-b2 is increased after fetal tracheal occlusion. Journal of Pediatric Surgery 34:701-705, 1999
  94. Liechty KW, Quinn TM, Cass DL, Crombleholme TM, Flake AW, Adzick NS. Elevated Platelet-Derived Growth Factor-B in congenital cystic adenomatoid malformations (CCAMS) requiring fetal resection. Journal of Pediatric Surgery 34:805-810, 1999
  95. Kitano Y, Davies P, von Allmen D, Adzick NS, Flake AW. Fetal tracheal occlusion in the rat model of nitrofen induced congenital  diaphragmatic hernia. Journal of Applied Physiology 87:769-775, 1999
  96. Flake AW, Zanjani ED. In utero hematopoietic stem cell transplantation. Ontologic opportunities and biologic barriers. Blood 94:2179-2191, 1999
  97. Zanjani ED, Flake AW, Almeida-Porada G, Tran N, Papayannopoulou T. Homing of human cells in the fetal sheep model: Modulation of antibodies activating or inhibiting Very Late Activation Antigen-4 dependent function. Blood 94:2515-2522, 1999
  98. Milner R, Shaaban AF, Kim HB, Flake AW. Increased donor cell engraftment after in utero stem cell transplantation with postnatal booster injections in an allogeneic strain combination. Surgical Forum L:406-407, 1999
  99. Shaaban AF, Kim HB, Milner R, Flake AW. Fetal liver is a superior donor source for the engraftment of prenatally transplanted allogeneic hematopoietic stem cells. Surgical Forum L:408-411, 1999
  100. Walsh DS, Long T, Olutoye O, Crombleholme TM, Flake AW, Adzick NS.  A new minimally invasive technique for fetal tracheal occlusion in congenital diaphragmatic hernia. Surgical Forum L:504-506, 1999
  101. Kitano Y, Radu A, Shaaban AF, Flake AW. Selection and expansion of early-cycling mesenchymal progenitors from murine bone marrrow by retroviral transduction. Surgical Forum L:550-552. 1999
  102. Kanai M, Kitano Y, Radu A, Adzick NS, Flake AW, von Allmen D. Effect of prenatal tracheal occlusion on pulmonary arterial structural changes in rats with nitrofen induced congenital diaphragmatic hernia. Surgical Forum L:567-568, 1999
  103. Madihally SV, Flake AW, Matthew HWT. Maintenance of CD34 expression during proliferation of CD34(+) cord blood cells on glycosaminoglycan surfaces. Stem Cells 17:295-305, 1999
  104. Shaaban AF, Kim HB, Milner R, Flake AW.  A kinetic model for homing and migration of prenatally transplanted marrow. Blood 94, 3251-3257, 1999
  105. Sutton LN, Adzick NS, Bilanuk LT, Johnson MP, Crombleholme TM, Flake AW. Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele. Journal of the American Medical Association 282:1826-1831, 1999
  106. Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED. Co-transplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Experimental Hematology 27:1569-1575, 1999
  107. Hubbard AM, Crombleholme TM, Adzick NS, Coleman BG, Howell LJ, Meyer JS, Flake AW. Perinatal MRI evaluation of congenital diaphragmatic hernia. American Journal of Perinatology 16:407-413, 1999
  108. Kitano Y, Flake AW, Quinn TM, Kanai M, Davies P, Sablich TJ, Schneider C, Adzick NS, von Allmen D. Lung growth induced by tracheal occlusion in the sheep is augmented by airway pressurization. Journal of Pediatric Surgery 35:216-222, 2000
  109. Milner R, Kitano Y, Oluyinka O, Flake AW, Adzick NS. Radiofrequency thermal ablation (RTA): A potential treatment for hydropic fetuses with a large chest mass. Journal of Pediatric Surgery 35:386-389, 2000
  110. Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, Glader B, Chew AJ, Tai SJ, Herzog RW, Arruda V, Johnson F, Scallan C, Skarsgard E, Flake AW, High KA. Evidence for gene transfer and expression of blood coagulation factor IX in patients with severe hemophilia B treated with an AAV vector. Nature Genetics 24:257-261, 2000
  111. Pameijer CR, Hubbard AM, Coleman B, Flake AW. Combined pure esophageal atresia, duodenal atresia, biliary atresia, and pancreatic ductal atresia: Prenatal diagnostic features and review of the literature. Journal of Pediatric Surgery 35:745-747, 2000
  112. Crombleholme TM, Sylvester KG, Flake AW, Adzick NS: Salvage of a fetus with congenital high airway obstruction syndrome (CHAOS). Fetal Diagnosis and Therapy 15:280-282, 2000.
  113. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AB, Deans R, Marshak DR, Flake AW. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Medicine 6:1282-1286, 2000.
  114. Flake AW, Crombleholme TM, Johnson MP, Howell LJ, Adzick NS. Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: Clinical experience with fifteen cases. American Journal of Obstetrics and Gynecology 183:1059-1066, 2000
  115. Walsh DS, Hubbard AM, Olutoye OO, Howell TM, Flake AW, Johnson MP, Adzick NS. Assessment of fetal lung volumes and liver herniation with magnetic resonance imaging in congenital diaphragmatic hernia. American Journal of Obstetrics and Gynecology 183:1067-1069, 2000
  116. Mahle WT, Rychik J, Tian ZY, Cohen MS, Howell LJ, Crombleholme TM, Flake AW, Adzick NS. Echocardiographic evaluation of the fetus with a congenital cystic adenomatoid malformation. Ultrasound in Obstetrics and Gynecology 16:620-624, 2000
  117. Kitano Y, Radu A, Shaaban AF, Flake AW. Selection, enrichment and culture expansion of murine mesenchymal progenitor cells by retroviral transduction of cycling adherent bone marrow cells. Experimental Hematology, 28:1460-1469, 2000
  118. Correia-Pinto J, Tavares ML, Baptista MJ, Estevão-Costa J, Flake AW, Leite-Moreira AF. A new fetal rat model of gastroschisis: Development and early characterization. Journal of Pediatric Surgery 36:213-216, 2000
  119. Hoydu AK, Kitano Y, Kriss A, Hensley H, Bergey B, Flake A, Hubbard A, Leigh JS. In vivo, in utero, microscopic magnetic resonance imaging of rat fetuses with nitrofen induced congenital diaphragmatic hernia. Magnetic Resonance in Medicine 44:331-335, 2000
  120. Kitano Y, Kanai M, Davies P, von Allmen D, Yang EY, Radu A, Kitano Y, Adzick NS, Flake AW. BAPS Prize 1999: Lung growth induced by prenatal tracheal occlusion and its modifying factors: A study in the rat model of congenital diaphragmatic hernia. Journal of Pediatric Surgery 36:251-259, 2001
  121. Kitano Y, von Allmen D, Kanai M, Quinn TM, Davies P, Kitano Y, Flake AW. Fetal lung growth after short term tracheal occlusion is linearly related to intratracheal pressure. Journal of Applied Physiology 90:493-500, 2001
  122. Kanai M, Kitano Y, von Allmen D, Davies P, Adzick NS, Flake AW. Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: Tracheal occlusion reverses the arterial structural abnormality. Journal of Pediatric Surgery 36:839-845, 2001
  123. MacKenzie TC, Howell LJ, Flake AW, Adzick NS. The management of prenatally diagnosed choledochal cysts. Journal of Pediatric Surgery  36:1241-1243, 2001
  124. MacKenzie TC, Shaaban AF, Radu A, Flake AW. Treatment of muscular dystrophy by in utero stem cell transplantation. Surgical Forum LII:328-29,  2001
  125. Flake AW. Prenatal Intervention: Ethical Considerations for Life-Threatening and Non-Life-Threatening Anomalies. Seminars in Pediatric Surgery 10:212-221, 2001
  126. Austin JC, Canning DA, Johnson MP, Flake AW, Carr MC. Vesicoamniotic shunt in a female fetus with prune belly syndrome. Journal of Urology 166:2382-2383, 2001
  127. MacKenzie TC, Flake AW. Multilineage Differentiation of Human MSC after In Utero Transplantation.  Cytotherapy 3:403-405, 2001
  128. Arruda VR, Fields PA, Milner R, Wainwright L, De Miguel MP, Donovan PJ, Herzog RW, Nichols TC, Biegel JA, Razavi M, Dake M, Huff D, Flake AW, Couto L, Kay MA, High KA.Lack of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant AAV-2 Vector in Males. Molecular Therapy 6:586-592, 2001.
  129. Correia-Pinto J, Tavares ML, Baptista MJ, Henriques-Coelho T, Estevão-Costa J, Flake AW, Leite-Moreira AF. Meconium dependence of bowel damage in gastroschisis. Journal of Pediatric Surgery 37:31-36, 2002.
  130. Krupnick AS, Kreisel D, Engels FH, Szeto WY, Plappert T, Popma SH, Flake AW, Rosengard BR. A novel small animal model of left ventricular tissue engineering. Journal of Heart and Lung Transplantation  21:233-43, 2002.
  131. Krupnick AS, Shaaban AF, Flake AW. Bone marrow tissue engineering. Tissue Engineering  8:145-155, 2002
  132. MacKenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS. The natural history of prenatally diagnosed conjoined twins.  Journal of Pediatric Surgery 37:303-309, 2002.
  133. Crombleholme TM, Coleman B, Hedrick H, Liechty K, Howell L, Flake AW, Johnson M, Adzick NS. Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. Journal of Pediatric Surgery 37:331-338, 2002.
  134. Correia-Pinto J, Reis  JL, Hutchins GM, Baptista MJ, Flake AW,  Leite-Moreira AF. In utero meconium exposure increases spinal cord necrosis in a rat model of myelomeningocele. Journal of Pediatric Surgery 37:488-492, 2002
  135. Bouchard S, Johnson MP, Flake AW, Adzick NS, Crombleholme TM: The EXIT procedure: experience and outcomes in 31 cases. Journal of Pediatric Surgery 37:418-426, 2002.
  136. MacKenzie TC,  Shaaban AF, Radu A, Flake AW. Engraftment of bone marrow and fetal liver cells after in utero transplantion in mdx mice. Journal of Pediatric Surgery 37:1058-1064, 2002
  137. Cohen MS, Rychik J, Bush DA, Tian ZY, Howell LJ, Long T, Adzick NS, Flake AW,  Johnson MP, Spray TL, Crombleholme TC. Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia Journal of Pediatrics 141:25-30, 2002
  138. Hayashi S, Peranteau W, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood 100:804-812, 2002
  139. MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S,Wilson JM, Verma IM, Flake AW. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Molecular Therapy  6:349-358, 2002 
  140. Davey MG, Hedrick HL, Kanai M, Mendoza JM, Adzick NS, Flake AW. Pulmonary epithelial liquid absorption, Expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion. Pediatric Pulmonology 34:278-286, 2002 
  141. Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. High level allogeneic chimerism achieved by a strategy of prenatal tolerance induction and postnatal non-myeloablative bone marrow transplantation. Blood 100:2225-2234, 2002
  142. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. The History of Fetal Diagnosis and Therapy: The Children’s Hospital of Philadelphia Experience. Fetal Diagnosis and Therapy 18:65-82, 2003
  143. Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW. Temporary tracheal occlusion in fetal sheep with severe lung hypoplasia does not improve postnatal
    respiratory function. Journal of Applied Physiology 94:1054-1062, 2003
  144. Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T, Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Experimental Hematology 31:176-184, 2003
  145. Vannucchi MG, Midrio P, Flake AW, Faussone-Pellegrini MS. Neuronal differentiation and myenteric plexus organization are delayed in gastroschisis. An immunohistochemical study in a rat model. Neuroscience Letters  339:77-81, 2003
  146. Davey MG, Hedrick HL, Bouchard S. Adzick NS, Flake AW, Doolin EJ. Computer-assisted sterology: point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning 25:37-44,  2003
  147. Manno CS, Chew AJ, Hutchison S, Larson PJ, Herzog RW, Arruda VR, Tai SJ, Ragni MV, Thompson A, Ozelo M, Couto LB, Leonard DG, Johnson FA, McClelland A, Scallan C, Skarsgard E, Flake AW, Kay MA, High KA, Glader B. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood. 101:2963-2972, 2003
  148. Keswani SG, Johnson MP, Adzick NS, Hori S, Howell LJ, Wilson RD, Hedrick H, Flake AW, Crombleholme TM. In utero limb salvage: Fetoscopic release of amniotic bands for threatened limb ischemia. Journal of Pediatric Surgery 38:848-851, 2003
  149. Lim F-Y, Crombleholme TM, Hedrick HL, Flake AW, Johnson MP, Howell LJ, Adzick NS. Congenital high airway obstruction syndrome: Natural history and management. Journal of Pediatric Surgery  38:940-945, 2003
  150. Kitano Y, von Allmen D, Kanai M, Adzick NS, Flake AW. Epinephrine Inhibits Tracheal Occlusion Induced Lung Growth in Fetal Sheep. Fetal Diagnosis & Therapy 18:333-337, 2003.
  151. Wilson RD, Johnson MP, Crombleholme TM, Flake AW, Hedrick HL, King M, Howell LJ, Adzick NS. Chorionic membrane separation following open fetal surgery: Pregnancy outcome. Fetal Diagnosis & Therapy 18:314-320, 2003
  152. Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ, Hedrick HL, Wilson RD, Adzick NS. Fetal myelomeningocele repair: Short term clinical outcomes. American Journal of Obstetrics and Gynecology 189:482-487, 2003
  153. Correia‑Pinto J, Baptista MJ, Pedrosa C, Estevão-Costa  J, Flake AW, Leite-Moreira AF. Fetal Heart Development in the Nitrofen-Induced CDH Rat Model. The role of mechanical and non-mechanical factors. Journal of Pediatric Surgery 38:1444-1451,  2003
  154. Olutoye OO, Johnson MP, Coleman BG, Crombleholme TM,  Adzick NS, Flake AW. Abnormal umbilical cord dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. Fetal Diagnosis & Therapy 18:428-431, 2003
  155. Bouchard S, MacKenzie TC, Radu A, Hayashi S, Peranteau WH, Chirmule N, Flake AW. Long-term Transgene Expression in Cardiac and Skeletal Muscle Following Fetal Administration of Adenoviral or Adeno-Associated Viral Vectors in Mice. The Journal of Gene Medicine 5:941-950, 2003
  156. Hedrick HL, Crombleholme TM, Flake AW, Nance ML, Von Allmen D, Howell LJ, Johnson MP, Wilson RD, Adzick NS. Right congenital diaphragmatic hernia: Prenatal assessment and outcome. Journal of Pediatric Surgery 39:319-323, 2004
  157. Flake AW. The conceptual application of systems theory to stem cell biology: A matter of context. Blood Cells, Molecules, and Diseases 32: 58-64, 2004
  158. Hayashi S, Hsieh MH, Peranteau WH, Ashizuka S, Flake AW. Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and co-transplantation of LLME treated, MHC sensitized, donor lymphocytes. Experimental Hematology 32:290-299, 2004
  159. Javazon EH, Beggs KJ, Flake AW. Mesenchymal Stem Cells: Paradoxes of Passaging. Experimental Hematology 32:414-25, 2004
  160. Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake AW, Crombleholme T, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS. Molecular response of the bladder to obstruction. Adv Exp Med Biol. 2003;539(Pt A):195-216.
  161. Biard JM, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, Adzick NS. Prenatally diagnosed giant omphaloceles: Short and long term outcomes. Prenatal Diagnosis 24:434-439, 2004
  162. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome. Journal of Pediatric Surgery 39:430-438, 2004
  163. Krupnick AS, Belsara KR, Kreisel D, Gelman A, Riha M, Sena-Esteves M, Rosengard BR, Flake AW. The fetal liver as a source of autologous progenitor cells for perinatal cardiac tissue engineering. Tissue Engineering 10:723-735, 2004
  164. Wilson RD, Baxter JK, Johnson MP, King M, Kasperski S, Crombleholme TM, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformations. Fetal Diagnosis & Therapy 19:413-20, 2004.
  165. Krag TOB, Bogdanovich S, Jensen CJ, Fischer MD, Hansen-Schwarz J, Javazon EH, Flake AW, Edvinsson L, Khurana TS. Heregulin ameliorates the dystrophic phenotype in mdx mice. Proceedings of the National Academy of Science 101:13856-13860, 2004
  166. Tang XX, Robinson ME, Riceberg JS, Kim DY, Kung B, Titus TB, Hayashi S, Flake AW, Carpentieri D, Ikegaki N. Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. Clinical Cancer Research 10:5837-5844, 2004
  167. Rychik J, Tian Z, Cohen MS, Ewing SG, Cohen D, Howell LJ, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, Adzick NS. Acute cardiovascular effects of fetal surgery in the human. Circulation. 110:1549-1556, 2004
  168. Midrio P, Faussone-Pellegrini MS, Vannucchi MG, Flake AW. Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells. Journal of Pediatric Surgery. 39:1541-1547, 2004.
  169. Javazon EH, Merchant AM, Danzer E, Flake AW. Reconstitution of hematopoiesis following intrauterine transplantation of stem cells. Methods in Molecular Medicine 105:81-94, 2004.
  170. Wilson RD, Johnson MP, Flake AW, Crombleholme TM, Hedrick HL, Wilson J, Adzick NS. Reproductive outcomes following pregnancy complicated by maternal-fetal surgery. American Journal of Obstetrics and Gynecology 191:1430-1436, 2004
  171. MacKenzie TC, Kobinger GP, Louboutin J-P, Radu A, Shah N, Javazon E, Sena-Esteves M, Wilson JM, Flake AW. Transduction of Satellite Cells After Prenatal Intramuscular Administration of Lentiviral Vectors  Journal of Gene Medicine 7:50-58, 2005
  172. Danzer E, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Sutton LN, Adzick NS. Fetal head biometry following in-utero repair of myelomeningocele. Ultrasound in Obstetrics and Gynecology. 24:606-611, 2004.
  173. Merchant AM, Flake AW. Surgeons and stem cells: a pragmatic perspective on shifting paradigms. Surgery 136:975-980, 2004
  174. Sena-Esteves M, Tebbets JC, Steffens S, Crombleholme T, Flake AW. Optimized large-scale production of high titer lentivirus vector pseudotypes. Journal of Virology Methods 122:131-9. 2004.
  175. Steffens S, Tebbets J, Cramm CM, Lindemann D, Flake A, Sena-Esteves M. Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes. Journal of Neuro-Oncology 70:281-288, 2004
  176. Keswani SG, Crombleholme TM, Pawel BR, Johnson MP, Flake AW, Hedrick HL, Howell LJ, Wilson RD, Davis GH, Adzick NS. Prenatal diagnosis and management of mainstem bronchial atresia. Fetal Diagnosis & Therapy 20:74-78, 2005
  177. Merchant AM, Hedrick HL, Crombleholme TM, Johnson MP, Wilson RD, Howell LJ, Adzick NS, Flake AW. Management of fetal mediastinal teratomas: A report of two cases.  Journal of Pediatric Surgery 40:228-231, 2005
  178. Baptista MJ, Melo-Rocha G, Pedrosa C, Gonzaga S, Teles A, Estevao-Costa J, Areias JC, Flake AW, Leite-Moreira AF, Correia-Pinto J. Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. Journal of Pediatric Surgery Apr;40(4):658-665, 2005. 
  179. Danzer E, Schwarz  U, Wehrli S, Radu A, Adzick NS, Flake AW. Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging. Experimental Neurology, 194:467-475, 2005
  180. Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, Adzick NS, Flake AW, Hedrick HL. Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia. Pediatric Pulmonology. 39(4):359-67. 2005
  181. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick. The ex utero intrapartum therapy procedure for high-risk fetal lung lesions. Journal of Pediatric Surgery. 40:1038-43, 2005.
  182. Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery Fetal Diagnosis & Therapy 20:316-20 2005.
  183. Fogel MA, Wilson D, Flake A, Johnson M, Cohen D, McNeal G, Tian Z-Y, Rychick J. A new method of functional assessment of the fetal heart using a novel application of “real time” cardiac magnetic imaging. Fetal Diagnosis & Therapy, 20:475-480, 2005
  184. Wilson RD, Hedrick HL, Liechty KW, Flake AW, Johnson MP, Bebbington J, Adzick NS. Cystic adenomatoid malformation of the lung: Review of genetics, prenatal diagnosis, and in utero treatment. American Journal of Medical Genetics 140:151-155, 2006
  185. Liechty KW, Hedrick HL, Hubbard AM, Johnson MP, Wilson RD, Ruchelli ED, Howell LJ, Crombleholme TM, Flake AW, Adzick NS. Severe pulmonary hypoplasia associated with giant cervical teratomas. Journal of Pediatric Surgery 41:230-233, 2006.
  186. Ashizuka S, Peranteau WH, Hayashi S, Flake AW. Busulfan Conditioned Bone Marrow Transplantation Results In High Level Allogeneic Chimerism In Mice Made Tolerant By In Utero Hematopoietic Cell Transplantation. Experimental Hematology 34:359-368, 2006
  187. Danzer E, Robinson LE, Davey MG, Schwarz U, Volpe M, Adzick NS, Flake AW, Hedrick HL. Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without effecting surfactant protein expression. Journal of Pediatric Surgery 41:774-780, 2006
  188. Haber BA,  Erlichman J, Thayu M, Flake AW, Rand EB. Successful Revision of Portoenterostomy in an Infant with Biliary Atresia. Journal of Pediatric Surgery 41(7):e1-e3, 2006
  189. Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, Adzick NS, Flake AW, Hedrick HL. Prenatal glucocorticoids and exogenous surfactant therapy improve lung compliance and gas exchange in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion. Pediatric Research 60:131-135, 2006
  190. Danzer E, Hubbard AM, Hedrick HL, Johnson MP, Wilson RD, Howell LJ, Flake AW, Adzick NS. Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal imaging. American Journal of Roentgenology 187:W350-356 , 2006
  191. Shaaban AF, Kim HB, Liechty KW, Flake AW. Prenatal Transplantation of cytokine-stimulated marrow improves early chimerism in a resistant strain combination but results in poor long-term engraftment. Experimental Hematology 34:1277-1286, 2006
  192. Adibe OO, Nichol PF, Flake AW, Mattei P.Comparison of outcomes after laparoscopic and open pyloromyotomy at a high-volume pediatric teaching hospital.  Journal of Pediatric Surgery 41:1676-8. 2006
  193. Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, Adzick NS, Flake AW, Hedrick HL. Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion. Pediatric Pulmonology. 41:1188-1196, 2006
  194. Peranteau WH, Endo M, Adibe O, Merchant A, Zoltick P, Flake AW. CD26 inhibition enhances allogeneic donor cell homing and engraftment after in utero hematopoietic cell transplantation. Blood 108:4268-4274, 2006
  195. Wilson RD, Pawel B, Bebbington M, Johnson MP, Lim F-Y, Stamilio D, Silber A, Zackai E, Flake AW.  Short Communication: Congenital pulmonary lymphangiectasis sequence: A rare, heterogeneous, and lethal etiology for prenatal pleural effusion. Prenatal Diagnosis 26:1058-1061, 2006.
  196. Peranteau WH, Endo M, Adibe O, Flake AW. Evidence for an adaptive immune barrier after in utero hematopoietic cell transplantation. Blood 109:1331-1333, 2007
  197. Danzer E, Kidoo DA, Redden RA, Robinson L, Radu A, Zderic SA, Doolin E, Adzick NS, Flake AW. Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid induced myelomeningocele. American Journal of Physiology; Renal Physiology 292:F197-206, 2007
  198. Henriques-Coelho T,  Gonzaga S, Endo M, Zoltick PW, Davey MG, Leite-Moreira AF, Correia-Pinto J, Flake AW. Targeted gene transfer to the fetal rat lung interstitium by ultrasound guided intraparenchymal injection. Molecular Therapy 15:340-347,  2007
  199. Endo M, Zoltick PW, Chung DC, Bennett J, Flake AW. Gene transfer to ocular stem cells by early gestational intra-amniotic injection of lentiviral vector. Molecular Therapy 15:579-587, 2007.
  200. Badillo AT, Beggs K, Javazon EH, Tebbets J, Flake AW. Murine mesenchymal stem cells elicit an in vivo cellular and humoral alloimmune response. Biology of Blood and Bone Marrow Transplantation 13:412-422, 2007
  201. Javazon  EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu A, Kozin ED, Beggs K, Malik AA., Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine mesenchymal stem cells. Wound Repair and Regeneration  15:350-359, 2007
  202. Wilson RD, Johnson MP, Bebbington M, Flake AW, Hedrick HL, Sutton LN, Adzick NS. Does a Myelomeningocele Sac Compared to No Sac Result in Decreased Postnatal Leg Function following Maternal Fetal Surgery for Spina Bifida Aperta?Fetal Diagnosis & Therapy 22:348-351, 2007.
  203. Netta DA, Wilson RD, Visintainer P, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Gastroschisis: Growth Patterns and a Proposed Prenatal Surveillance Protocol. Fetalal Diagnosis & Therapy 22:352-357, 2007.
  204. Peranteau WH, Wilson RD, Liechty KW, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Effect of Maternal Betamethasone Administration on Prenatal Congenital Cystic Adenomatoid Malformation Growth and Fetal Survival. Fetal Diagnosis & Therapy. 22:365-371, 2007.
  205. Merchant AM, Peranteau W, Wilson RD, Johnson MP, Bebbington MW, Hedrick HL,  Flake AW, Adzick NS. Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation. Fetal Diagnosis & Therapy. 22:435-439, 2007
  206. Sabatino DE, MacKenzie TC,  Peranteau WH, Campagnoli C, Liu Y-L, Flake AW, High KA. Persistent expression of hF.IX after tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Molecular Therapy 15:1677-1685, 2007
  207. Hedrick HL, Danzer E, Merchant A, Bebbington MW, Zhao H, Flake AW, Johnson MP, Howell LJ, Wilson RD, Adzick NS. Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia. American Journal of Obstetrics and Gynecology 197:422e1-4, 2007
  208. Davey M, Shegu S, Danzer E, Ruchelli E, Adzick NS, Flake AW, Hedrick HL. Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoids therapy. American Journal of Obstetrics and Gynecology 197:381e1-7, 2007.
  209. Bebbington MW, Danzer E, Hedrick HL, Flake AW, Wilson RD, Johnson MP, Adzick NS. OC223: Serial measurement of lung head ratio (LHR) does not predict survival in left-sided congenital diaphragmatic hernia (CDH). Ultrasound in Obstetrics and Gynecology 30:435, 2007
  210. Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW. Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intra-amniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter. Molecular Therapy 16: 131-137, 2008 
  211. Tsai AY, Liechty KW, Hedrick HL, Bebbington M, Wilson RD, Johnson MP, Howell LJ, Flake AW, Adzick NS. Outcomes following postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions. Journal of Pediatric Surgery 43:513-517, 2008
  212. Tiblad E, Wilson RD, Carr M, Flake AW, Hedrick HL, Johnson MP, Bebbington MW, Mann S, Adzick NS. OEIS sequence – a rare congenital anomaly with prenatal evaluation and postnatal outcome in six cases. Prenatal Diagnosis 28:141-147, 2008
  213. Badillo AT, Peranteau WH, Heaton TE, Quinn C, Flake AW. Murine Bone Marrow Derived Stromal Progenitor Cells Fail to Prevent or Treat Acute Graft Versus Host Disease. British Journal of Haematology 141:224-234, 2008
  214. Danzer E, Radu A, Robinson LE, Volpe MV, Adzick NS, Flake AW. Morphological analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele Neuroscience Letters 430:157-162,  2008.
  215. Badillo AT, Hedrick HL, Wilson RD, Danzer E, Bebbington MW, Johnson MP, Liechty KL, Flake AW, Adzick NS. Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. Journal of Pediatric Surgery 43:647-653, 2008
  216. Biard JM, Schwarz U, Davey MG, Danzer E, Johnson MP, Flake AW, Adzick SN, Hedrick HL. Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs. Journal of Pediatric Surgery 43:620-626, 2008.
  217. Tran KM, Flake AW, Kalawadia NV, Maxwell LG, Rehman MA. Emergent excision of a prenatally diagnosed sacrococcygeal teratoma. Paediatric Anaesthesia. 18:431-434, 2008
  218. Laje P, Peranteau WH, Flake AW. Repair of Indirect Inguinal Hernias by Laparoscopic Joining of the Edges. Surgical Laparoscopic and Endoscopic Percutaneous Techniques.18:280-282, 2008
  219. Ibele A, Flake AW, Shaaban A. Survival of a profoundly hydropic fetus with a sacrococcygeal teratoma delivered at 27 weeks of gestation for maternal mirror syndrome. Journal of Pediatric Surgery. 43:e17-20, 2008
  220. Behrens EM, Ning Y, Muvarak N, Zoltick PW, Flake AW, Gallucci S, Apoptotic Cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization. Journal of Immunology, 181:3018-3026, 2008
  221. Peranteau WH, Merchant AM, Hedrick HL, Liechty KW, Howell LJ, Flake AW, Wilson RD, Johnson MP, Bebbington MW, Adzick NS.  Prenatal Course and Postnatal Management of Peripheral Bronchial Atresia: Association with Congenital Cystic Adenomatoid Malformation of the Lung. Fetal Diagnosis & Therapy. 24:190-196. 2008
  222. Mong A, Johnson AM, Kramer SS, Coleman BG, Hedrick HL, Kreiger P, Flake A, Johnson M, Wilson RD, Adzick NS, Jaramillo D. Congenital High Airway Obstruction Syndrome: MR/US findings, effect on management, and outcome. Pediatric Radiology, 38:1171-1179, 2008
  223. Gonzaga S, Henriques-Coelho T, Davey M, Zoltick PW, Leite-Moreira AF, Correia-Pinto J, Flake AW. Cystic Adenomatoid Malformations are Induced by Localized FGF10 overexpression in the fetal rat lung. American Journal of Respiratory Cell and Molecular Biology. 39:346-355 2008.
  224. Danzer E, Davey MG, Kreiger PA, Ruchelli ED, Johnson MP, Adzick NS, Flake AW, Holly L Hedrick. Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: A morphometric study of lung parenchyma and muscularization of Pulmonary Arterioles. Journal of Pediatric Surgery, 43:1767-1775, 2008
  225. Danzer E, Adzick NS, Rintoul NE, Zarnow DM, Schwartz ES, Melchionni J, Flake AW, Sutton LN, Johnson MP. Intradural inclusion cysts following in utero myelomeningocele closure: clinical implications and follow-up. Journal of Neurosurgery Pediatrics, 2:406-413, 2008
  226. Wilson RD, Hedrick H, Flake AW, Johnson MP, Bebbington MW, Mann S, Rychik J, Liechty K, Adzick NS. Sacrococcygeal Teratomas: Prenatal Surveillance, Growth and Pregnancy Outcome. Fetal Diagnosis & Therapy, 25:15-20. 2008
  227. Danzer E, Ernst LM, Rintoul NE, Johnson MP, Adzick NS, Flake AW. In utero meconium passage in fetuses and newborns with myelomeningocele. Journal of Neurosurgery Pediatrics 3:141-146, 2009
  228. Niiya M, Endo M, Zoltick PW, Muvarak NE, Motto DG, Ginsburg D, Flake AW, Zheng XL. Correction of Adamts13-deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes. Molecular Therapy 17:34-41, 2009
  229. Deprest JA, Hyett JA, Flake AW, Nicolaides K, Gratacos E. Current controversies in prenatal diagnosis 4: Should fetal surgery be done in all cases of severe diaphragmatic hernia? Prenat Diagn. 29:15-19, 2009.
  230. Peranteau WH, Heaton TE, Gu Y-C, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW. Haploidentical In Utero Hematopoietic Cell Transplantation Improves Phenotype and Can Induce Tolerance for Postnatal Same Donor Transplants in the Canine Leukocyte Adhesion Deficiency Model.  Biology of Blood and Bone Marrow Transplantation 15:293-305, 2009
  231. Laje P, Shang D, Cao W, Niija M, Endo M, Radu A, DeRogatis N, Scheiflinger F, Zoltick PW, Flake AW, Zheng XL, Correction of ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy. Blood 113:2172-2180, 2009
  232. Merianos DJ, Tiblad E, Santore MT, Laje P, Endo M, Zoltick PW, Flake AW. Maternal alloantibodies transferred via breast milk induce a postnatal immune response that breaks tolerance after in utero hematopoietic cell transplantation. Journal of Clinical Investigation 119:2590-2600, 2009
  233. Nallasamy S, Davidson SL, Howell LJ, Hedrick H, Flake AW, Crombleholme TM, Adzick NS, Young TL. The effects of fetal surgery on retinopathy of prematurity development. Opthalmology and Eye Diseases 1:13-19, 2009
  234. Endo M, Henriques-Coelho T, Zoltick PW, Stitelman DH, Peranteau WH, Radu A, Flake AW. Developmental stage determines distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors. Gene Therapy 17:61-71, 2010.
  235. Laje P, Muvarak N, Zoltick PW, Flake AW. A comparison of transduction efficiency and long-term repopulating capacity of lentiviral transduced SLAM versus KSL-enriched HSC using an abbreviated transduction protocol. Gene Therapy 17:412-418, 2010
  236. Danzer E, Gerdes M, D’Agostino J, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Adzick NS, Flake AW, Hedrick HL: Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. Journal of Pediatric Surgery 45:718-723, 2010.
  237. Watanabe M, Jo J, Radu A, Kaneko M, Tabata Y, Flake AW. A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor. Tissue Engineering Part A 16:1645-1655, 2010
  238. Danzer E, Layne MD, Auber F, Shegu S, Kreiger P, Radu A, Volpe M, Adzick NS, Flake AW. Gastroschisis in mice lacking aortic carboxypeptidase-like protein (ACLP) is associated with a defect in neuromuscular development restricted to the eviscerated intestine: early characterization and histomorphological assessment.  Pediatric Research 68:23-28, 2010
  239. Laje P, Flake AW, Adzick NS Prenatal diagnosis and postnatal resection of intraabdominal enteric duplications. Journal of Pediatric Surgery 45:1554-1558, 2010
  240. Laje P, Clark FH, Friedman JR, Flake AW.  Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia.  Journal of Pediatric Surgery 45:1554-1558, 2010
  241. Roybal J, Liechty KW, Hedrick HL, Bebbington M, Johnson MP, Coleman B, Adzick NS, Flake AW. Predicting severity of Congenital High Airway Obstruction Syndrome. Journal of Pediatric Surgery 45:1633-1639, 2010
  242. Danzer E, Gerdes M, Bernbaum J, D'Agostino J, Bebbington MW, Siegle J, Hoffman C, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program. Journal of Pediatric Surgery. 45:1759-1766, 2010.
  243. Kaye AJ, Rand EB, Munoz P, Spinner NB, Flake AW, Kamath BM. Effect of Kasai Procedure on the Hepatic Outcome in Alagille Syndrome. Journal of Pediatric Gastroenterology and Nutrition 51:319-321, 2010.
  244. Bertozzi CC, Schmaier AA, Mericko P, Hess P, Zou Z, Chen M, Chen C-Y, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Meriano DJ, Stadfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signalling. Blood 116:661-670, 2010
  245. Stitelman DH, Endo M, Bora A, Muvarak N, Zoltick PW, Flake AW, Brazelton TR. Robust in vivo transduction of nervous system and neural stem cells by early gestational intra-amniotic gene transfer using lentiviral vector. Molecular Therapy, 18:1615-1623, 2010
  246. Wilson RD, Lemerand K, Johnson MP, Flake AW, Bebbington M, Hedrick HL, Adzick NS. Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007). American Journal of Obstetrics and Gynecology. 209 e1-6, 2010
  247. Santore MT, Behar BJ, Blinman TA,  Doolin EJ, Hedrick HL, Mattei P, Nance ML, Adzick NS, Flake AW. Hepaticoduodenostomy versus hepaticojejunostomy for reconstruction after resection of choledochal cyst. Journal of Pediatric Surgery 46:209-213, 2011
  248. Danzer E, Zhang L, Radu A, Bebbington MW, Liechty KW, Adzick NS, Flake AW. Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury. American Journal of Obstetrics and Gynecology 204:178.e1-178.e11, 2011
  249. Roybal JL, Moldenhauer JS, Khalek N, Bebbington MW, Johnson MP, Hedrick HL, Adzick NS, Flake AW. Early delivery as an alternative management strategy for select high –risk fetal sacrococcygeal teratomas. Journal of Pediatric Surgery 46:1325-1332, 2011
  250. Watanabe, M, Li H, Roybal JL, Santore MT, Radu A, Jo J, Kaneko M, Tabata Y, Flake AW. A Tissue Engineering Approach for Prenatal Closure of Myelomeningocele: Comparison Of Gelatin Sponge And Microsphere Scaffolds And Bioactive Protein Coatings. Tissue Engineering (7-8):1099-110, 2011
  251. Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators.  A randomized trial of prenatal versus postnatal repair of myelomeningocele. New England Journal of Medicine. 364:993-1004, 2011.
  252. Roybal JL, Endo M, Radu A, Zoltick PW, Flake AW. Early gestational gene transfer of IL-10 by systemic administration of lentiviral vector can prevent arthritis in a murine model. Gene Therapy 18:719-726, 2011.
  253. Hakguder G, Olguner M, Gurel D, Akgur FM, Flake AW. Induction of fetal diuresis with intraamniotic furosemide injection reduces intestinal damage in a rat model of gastroschisis. European Journal of Pediatric Surgery 21:183-18, 2011
  254. McCloskey JJ, Motas D, Cohen D, Jarcher MD, Flake AW. Fluoroscopic-assisted endobronchial intubation for single lung ventilation in infants. Pediatric Anesthesia 6:681-684, 2011
  255. Santore MT, Deans KJ, Behar BJ, Blinman TA, Adzick NS, Flake AW. Laparoscopic hepaticoduodenostomy versus open hepaticoduodenostomy for reconstruction after resection of choledochal cyst. Journal of Laparoendoscopic & Advanced Surgical Techniques. 21:375-378, 2011
  256. Davey MG, Zoltick PW, Todorow CA, Limberis MP, Hedrick HL, Flake AW. Jaagsiekte sheep retrovirus pseudotyped lentivirus-mediated gene transfer to fetal ovine lung. Gene Therapy 19:201-209, 2012
  257. Superina R, Magee JC, Brandt ML, Healy PJ, Tiao G, Ryckman F, Karrer FM, Iyer K, Fecteau A, West K, Burns RC, Flake AW, Lee H, Dillon P, Colombani P, Ricketts R, Li Y, Moore J, Wang KS; The Childhood Liver Disease Research and Education Network. The anatomic pattern of biliary atresia identified at the time of Kasai Hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant free survival. Annals of Surgery 254:577-585, 2011.
  258. Endo M, Zoltick PW, Radu A, Qiujie J, Matsui C, Marinkovich PM, McGrath J, Tamai K, Uitto J, Flake AW. Early Intra-amniotic gene transfer using lentiviral vector improves skin phenotype in a murine model of Herlitz junctional epidermolysis bullosa. Gene Therapy (in press), 2011
  259. Danzer E, Victoria T, Bebbington MW, Siegle J, Rintoul NE, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Fetal MRI-calculated total lung volumes in the prediction of short term outcome in giant omphalocele – Preliminary findings. Fetal Diagnosis and Therapy (in press) 2011
  260. Danzer E, Zarnow D, Gerdes M, D’Augustino JA, Siegle J, Bebbington MW, Flake AW Adzick NA, Hedrick HL. Abnormal brain development and maturation on MR imaging in survivors of severe congenital diaphragmatic hernia. Journal of Pediatric Surgery 47:453-461, 2012
  261. Roybal JL, Endo M, Radu A, Gray L, Todorow CA, Zoltick PW, Lutsenko S, Flake AW. Early gestational gene transfer with lentiviral vector driven by a liver promotor targets the fetal liver and improves phenotype in a murine model of Wilson’s Disease. Gene Therapy, In Press, 2011
  262. Tsai J, Sulkowski J, Adzick NS, Hedrick HL, Flake AW. Patch repair for congenital diaphragmatic hernia: Is it really a problem? Journal of Pediatric Surgery, 47:637-641, 2012.
  263. Danzer E, Siegle J., D’Agostino J, Gerdes M, Hoffman C, Bernbaum J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Early neurodevelopmental outcome of infants with high-risk fetal lung lesions. Fetal Diagnosis and Therapy, In Press, 2012
  264. Buchlis G, Podsakoff GM, Radu A, Hawk SM, Flake AW, Mingozzi F, High KA. Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer. Blood 119:3038-3041, 2012
  265. Danzer E, Victoria T, Bebbington MW, Siegle J, Rintoul NE, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: Preliminary findings. Fetal Diagnosis and Therapy (in Press) 2012
Articles Submitted
  1. Stitelman DH, Endo M, Bora A, Traas J, Zoltick PW, Flake AW, Brazelton TR. Life-long transgene expression in skeletal muscle without transduction of satellite cells following embryonic myogenic progenitor transduction by lentiviral vector administered in utero. Submitted 2011
  2. Triantafellow E, Radu A, Ponath PD, Waldmann H, Flake AW, Ozkaynak E. Interaction of Ly49G+ NK cells with Tregs and mature dendritic cells in tolerated mouse cardiac allografts: essential role for the Ly49G receptor in tolerance. Submitted 2011
  3. Wu C, Endo M, Yang BH, Radecki MA, Spivak RM, Davis PF, Zoltick PW, Flake AW, Kirschner RA, Nah H-D. Intra-amiotic Administration of An Adenovirus Expressing TGFb3 Rescues Cleft Palate in Tgfb3-/- Mice: Transient Peridermal Expression of TGFb3 is Sufficient To Induce Fusion and Disappearance of the Palatal Shelf Medial Edge Epithelium. Submitted 2011
  4. Danzer E, Adzick NS, Flake AW, Hedrick HL, Use of Magnetic Resonance Imaging in Prenatal Prognosis of the Fetus with Isolated Left Congenital Diaphragmatic Hernia’ Submitted 2012
Published Abstracts
  1. Flake AW, Harrison MR, Adzick NS, Zanjani ED:  Creation of hematopoietic chimeras without GVHD by in-utero transplantation of fetal hematopoietic cells. Clin Research 34:458A, 1986.
  2. Burke EC, Bethel CAI, Flake AW, Freise CE, Ascher NL. Isolation, MHC expression and function of isolated fetal hepatocytes from fetal livers preserved in UW solution. FASEB Journal 5:623, 1991
  3. Flake AW, Hedrick MH, Rice HE, Tavassoli M, Zanjani ED.  Enhancement by stem cell factor of human cell engraftment and hematopoiesis in human/sheep hematopoietic chimeras. (Abstract) Blood 80 Suppl 1:150A, 1992.
  4. Zanjani ED, Flake AW, Tavassoli M:  Long term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells (HSC) in sheep.  (Abstract) Blood 80 Suppl 1:244A, 1992.
  5. Rice HE, Flake AW, Emani VR, Hedrick MH, Knazek R, Zanjani ED, Harrison MR:  "Ex vivo expansion of hematopoietic stem cells from human fetal liver in an artificial capillary system. Blood 82 Suppl 1:18A 1993.
  6. Flake AW, Porada CD, Tavassoli M, Zanjani ED:  Comparison of potential for graft vs. host disease (GVHD) of fetal hematopoietic stem cells (HSC) from fetal, neonatal, and adult sources. Blood 82 Suppl 1:299A 1993.
  7. Porada, CD, Moen R, Troutman L, Flake AW, Rice HE, Hedrick MH, Anderson WF, Zanjani ED: In-vivo gene transfer into fetal animals.  Blood 82 Suppl 1:315A, 1993.
  8. Zanjani ED, Flake AW, Rice HE, Hendrick MH, Tavassoli M:  An in-vivo comparison of potential human donor hematopoietic stem cell (HSC) sources for bone marrow transplantation using the human/sheep xenograft model.  Blood 82 Suppl 1:655A 1993.
  9. Rice HE, Skarsgard ED, Emani VR,Knazek RA, Zanjani ED, Flake AW, Harrison MR: Human fetal liver hematopoietic stem cell expansion with use of novel biorector system.  Cell Transplantation 3:219 Abstract 33, 1994.
  10. Adzick NS, Harrison MR, Flake AW, Filly RA, Goldberg JD, Howell LJ:  Fetal lung lesions:  Management and outcome.  Am J Ob Gyn 170:399, 1994.
  11. Skarsgard ED, Rice HE, Emani VR, Harrison MR, Zanjani ED, Flake AW:  An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells. Cell Transplantation 3:222, Abstract 44, 1994.
  12. Flake AW, Puck JM, Ameida-Porada G, Evans MI, Johnson MP, Roncarolo M-G, Zanjani ED: Successful treatment of x-linked severe combined immunodeficiency (X-SCID) by the in-utero transplantation of CD34 enriched paternal bone marrow." Blood 86:125a, Abstract 487, 1995.
  13. Zanjani ED, Kawashima I, Almeida-Porada G, Zeng HQ, Leary AG, Flake AW, Ogawa M: Human/sheep hematopoietic chimerism: a relatively specific and sensitive model for the in vivo assay of human hematopoietic stem cells (HSC). Blood 86:487a Abstract 1935, 1995.
  14. Flake AW, Johnson MP, Treadwell M, Mason B, Cauldwell C, Philippart AI, Cullen ML, O'Brien J, Adzick NS, Harrison MR, Evans MI:  In utero treatment of right-sided congenital diaphragmatic hernia (R-CDH) by prenatal tracheal occlusion.  American Journal of Obstetrics and Gynecology SPO edition, 1995.
  15. Treadwell MC, Tomlinson MW, Wolfe HM, Flake AW:  Prenatal coarse of congenital cystic adenomatoid malformations.  American Journal of Obstetrics and Gynecology SPO edition, 1995.
  16. Hedrick MH, Rice HE, Zanjani ED, Johnson D, Flake AW, Harrison MR.  Flow cytometry for the detection of hematopoietic chimerism after in-utero hematopoietic stem cell transplantation: the swine into sheep model.  Journal of Analytical Cytometry Abstract, 1995.
  17. Flake AW, Zanjani ED:  In utero stem cell transplantation in humans.  In Vitro 32:10A Abstract V-4, 1996.
  18. Flake AW, Puck JM, Ameida-Porada G, Evans MI, Johnson MP, Roncarolo M-G, Zanjani ED. Persistence of engraftment and documentation of donor-derived CD34+/CD38- cells in the recipient bone marrow after in utero transplantation for X-linked severe combined immunodeficiency. Blood Supple 1 88:Abstract 1054, 1996
  19. Flake AW. Chirurgie foetale des hernies de coupole. Medicine Foetale Et Echographie en Gynecologie 28:10-11, 1996
  20. Kim HB, Shabaan AF, Yang EY, Milner R, Flake AW. Donor specific tolerance in a murine model of in utero stem cell transplantation requires hematopoietic microchimerism and is dependent on donor cell source. Blood Supple 1 90:363a Abstract 1618, 1997 21.
  21. Shaaban AF, Kim HB, Liechty KW, Milner R, Flake AW. Blockade of a4 or bintegrins impairs homing of prenatally transplanted allogeneic marrow to the fetal liver. Blood Supple 1 90:488a Abstract  2168, 1997.
  22. Shaaban AF, Kim HB, Yang EY, Flake AW. A murine model of prenatal hematopoietic homing. Blood Supple 1 90:94a Abstract 414, 1997
  23. Madihally SV, Flake AW, Matthew HWT. The role of glycosaminoglycans in expanding a CD34+ cell population. Blood Supple 1 90:483a Abstract 2148, 1997
  24. Adzick NS, Harrison MR, Crombleholme TM, Flake AW, Howell LR. Open fetal surgery for congenital cystic adenomatoid malformation. American Journal of Obstetrics and Gynecology. 178:S28, Abstract 66, 1998
  25. Johnson MP, Sharma R, Yaron Y, Kramer RL, Evans MI, Flake AW. Intact embryo aspiration as a source of viable hematopoietic stem cells. American Journal of Obstetrics and Gynecology. 178:S151, Abstract 527, 1998
  26. Shabaan AF, Kim HB, Milner R, Fichter C, Flake AW. Pretreatment of prenatally transplanted allogeneic marrow with VEGF and SCF delays allograft rejection in chimeric mice. Pediatrics 102 Pt 2:796, Abstract P1, 1998
  27. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. Pediatrics 102 Pt 2:792, Abstract 16, 1998 1998
  28. Quinn TM, Sylvester KG, Kitano Y, Kitano Y, Jarrett BP, Sablich TJ, Adzick NS, Flake AW. TGF-b2 is increased after fetal tracheal occlusion.  Pediatrics 102 Pt 2:796, Abstract 11, 1998
  29. Liechty KW, Quinn TM, Cass DL, Crombleholme TM, Flake AW, Adzick NS. Elevated PDGF-B in congenital cystic adenomatoid malformations (CCAMS) requiring fetal resection. Pediatrics 102 Pt 2:806, Abstract 30,1998
  30. Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Fetal intramuscular delivery of recombinant adenovirus results in persistent postnatal transgene expression in both muscle and liver. Pediatrics 102 Pt 2:794, Abstract 23, 1998
  31. Almeida-Porada G, Flake AW, Zanjani ED. Cotransplantation of sheep stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Blood 92 Supple 1:116a, Abstract 472, 1998.
  32. Leichty KW, Milner R, Shaaban AF, Mosely AB, Deans R, Thiede M, Flake AW. Distribution and engraftment of human mesenchymal stem cells (MSC) after in utero transplantation in fetal sheep. Blood 92 Supple 1:117a, Abstract 474, 1998
  33. Shaaban AF, Kim HB, Milner R, Radu A, Flake AW. Developmentally related changes in VLA-4, VCAM, and CD44 expression may explain the switch from liver to marrow hematopoiesis. Blood 92 Supple 1:582a, Abstract 2398, 1998
  34. Milner R, Shaaban AF, Kim HB, Fichter C, Scully M, Asakura T, Flake AW. Long term high level expression of donor hemoglobin after in utero HSC transplantation in knockout mice – Selective advantage for donor red cells. Blood 92, Supple 1: Abstract 2864, 1998
  35. Shaaban AF, Kim HB, Milner R, Flake AW. Natural killer cell Ly49 inhibitory receptor expression is influenced by early exposure to foreign antigen – A possible mechanism for developmental natural killer cell regulation. Blood 92, Supple 1: Abstract 2951, 1998
  36. Kitano Y, Shaaban AF, Kim HB, Milner R, Liechty KW, Kanai M, Knight AK, Flake AW.  Distribution and engraftment of cultured murine marrow stromal cells after in utero transplantation. Blood 92, Supple 1: Abstract 2953, 1998
  37. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. Mechanisms of tolerance after in utero bone marrow transplantation. Blood 92, Supple 1: Abstract 2954, 1998
  38. Milner R, Shaaban AF, Kim HB, Fichter C, Flake AW. Natural killer cells do not mediate allograft rejection after in utero hematopoietic stem cell transplantation. Blood 92, Supple 1 part 2: Abstract 4243, 1998
  39. Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. Clonal deletion and tolerance after in utero bone marrow transplantation in mice. Transplantation 66:S28, Abstract 112, 1998
  40. Jackson GM, Rose NC, Morgan MA, Gaiser RR, Cheek TG, Crombleholme TM, Flake AW, Adzick NS. Short-term maternal outcome following open fetal surgery. American Journal of Obstetrics and Gynecology 180 Number 1, Part 2:S139, Abstract #483, 1999
  41. Leichty KW, Crombleholme TM, Coleman BG, Howell LJ, Flake AW, Adzick NS. Elevated cystic adenomatoid malformation volume ratio (CVR) is associated with development of hydrops. American Journal of Obstetrics and Gynecology 180 Number 1, Part 2:S165, 1999
  42. Kitano Y, von Allmen D, Flake AW, Korimilli A, Guttentag SH. Effects of fetal tracheal occlusion on alveolar type 2 cell number and maturation in the rat. Pediatric Research 45 APS/SPR Program Issue, Abstr 1811, 1999
  43. Kitano Y, von Allmen D, Kanai M, Flake AW. The impact of terbutaline administration on lung growth following prenatal tracheal occlusion. Pediatric Research 45 APS/SPR Program Issue, Abstr 1811, 1999
  44. Shaaban AF, Milner R, Kim HB, Fichter C, Flake AW. Donor natural killer cell Ly49 inhibitory profile is altered by development in an MHC mismatched recipient environment following in utero hematopoietic stem cell transplantation. Transplantation 67:S573, Abstr 121, 1999
  45. Shaaban AF, Milner R, Kim HB, Fichter C, Flake AW. Donor T cell education in stable high-level hematopoietic chimeric mice after prenatal MHC- disparate hematopoietic stem cell transplantation. Transplantation 67:S605, Abstr 252, 1999
  46. Flake AW, Zanjani ED. Experimental in utero hematopoietic stem cell transplantation. Experimental Hematology 27 Supple. 1:134 Abstr 373, 1999
  47. Shaaban AF, Milner R, Kim HB, Flake AW. Fetal liver is a superior donor source for the engraftment of prenatally transplanted allogeneic hematopoietic stem cells. Experimental Hematology 27 Supple 1:121 Abstr 320, 1999
  48. Leichty KW, Milner R, Shaaban AF, Mosely AB, Deans R, Thiede M, Flake AW. Distribution and engraftment of human mesenchymal stem cells after in utero transplantation in sheep. Experimental Hematology 27 Supple 1:37 Abstr 2, 1999
  49. Shaaban AF, Milner R, Kim HB, Flake AW. High-level allogeneic hematopoietic chimerism following prenatal stem cell transplantation requires negative selection of donor thymocytes mediated by host antigen presentation cells. Experimental Hematology 27 Supple 1:128 Abstr 347, 1999
  50. Knight AK, Kanai M, Sablich T, Flake AW. Pressure induced mucosal growth in neonatal small intestine. Pediatrics 104 Supplement 3: 782 Abstr 2, 1999
  51. Manno CS, Herzog RW, Arruda VR, Couto LB, Tai SJ, McClelland A, Flake AW, Chew AJ, Fields PA, Armstrong AE, Leonard D, Skarsgard ED, Glader BE, Ragni MV, Larson PJ, Kay MA, High KA. A Phase I trial of AAV-mediated muscle-directed gene therapy for hemophilia B. Blood 94 Supple 1: 642a Abstr 2852, 1999
  52. Shaaban AF, Milner R, Kim HB, Fichter C, Flake AW. Absence of MHC restriction facilitates equal engraftment of prenatally transplanted congenic or allogeneic hematopoietic cells with predictable donor-specific tolerance. Blood 94 Supple 1:320a Abstr. 1429, 1999
  53. Shaaban AF, Kim HB, Milner R, Hayashi S, Fichter C, Flake AW. Bias toward natural killer T cell production among donor lymphocytes in chimeric hosts suggests role in the maintenance of tolerance following in utero hematopoietic stem cell transplantation. Blood 94 Supple 1:322a Abstr. 1439, 1999
  54. Flake AW, Crombleholme TM, Johnson MP, Howell LJ, Adzick NS. Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: Clinical experience with fifteen cases. American Journal of Obstetrics and Gynecology 182 (No. 1, part 2):S16, Abstract 10, 2000
  55. Walsh DS, Johnson MP, King M, Flake AW, Crombleholme TM, Sutton LN, Bar M, Adzick. Head circumference and ventricular size following in utero closure of myelomeningocele. American Journal of Obstetrics and Gynecology 182 (No. 1, part 2):S16, Abstract 9, 2000
  56. Walsh DS, Hubard AM, Olutoye OO, Crombleholme TM, Flake AW, Johnson MP, Adzick NS. Asessment of fetal lung volumes and liver herniation with magnetic resonance imaging in congenital diaphragmatic hernia. American Journal of Obstetrics and Gynecology 182 (No. 1, part 2):S16, Abstract 12, 2000
  57. Crombleholme TM, Walsh DS, Long T, Howell LJ, Flake AW, Adzick NS. Use of quantitative PCR to detect fetal-maternal transfusion following fetal surgery. American Journal of Obstetrics and Gynecology 182 (No. 1, part 2):S170, Abstract  546, 2000.
  58. Oepkes D, Windrim R, Seaward PGR, Barrett JFR, Davies GAL, Hornberger L, Flake AW, Kelly EN, Ryan G. Congenital Cystic Adenomatoid Malformation of the lung with fetal hydrops: A spectrum of in utero management. American Journal of Obstetrics and Gynecology 182 (No. 1, part 2):S173, Abstract 558, 2000.
  59. Shaaban AF, Kim HB, Pameijer C, Fichter C, Flake AW. Direct antigen presentation by donor cells in prenatal hematopoietic chimeras results in deletion of donor reactive T cell clones without MHC restriction. Transplantation 69 Supple.:S241 Abstract 500, 2000.
  60. Manno CS, Glader B, Ragni MV, Thompson A, Costal F, Chew AJ, Herzog RW, Arruda VR, Tai SJ, Couto LB, Johnson F, McClelland A, Flake AW, Fields PA, Armstrong E, Leonard D, Skaarsgard E, Larson PJ, Kay MA, High KA. A Phase I Trial of AAV-mediated Muscle-directed Gene Therapy for Hemophilia B. Molecular Therapy 1(Part 2 of 2):S128 Abstract 326, 2000
  61. Bouchard S, Saydam TC, Shaaban AF, Hayashi S, Parmeijer CR, Chirmule N, Flake AW. Preimmune administration of adeno-associated virus allows postnatal readministration without a neutralizing antibody response. Molecular Therapy 1(Part 2 of 2):S299:2000
  62. Hayashi S, Shaaban AF, Peranteau WJ, Abdulmalik O, Chen Q, Asakura T, Flake AW. High-level expression of donor hemoglobin and decrease in the level of membrane associated denatured hemoglobin (MADH) as an indicator of disease severity after in utero bone marrow transplantation in a murine model of b-thalassemia. Blood 96 Suppl. 1 of 2:174a Abstract 748, 2000
  63. MacKenzie TC, Pameijer CR, Almeida-Porada G, Mackay AM, Deans RJ, Flake AW. Human mesenchymal stem cells persist and migrate to tissues of injury in the prenatal lamb recipient. Blood 96 Suppl.1 of 2:763a Abstract 3299, 2000
  64. Manno CS, Glader B, Ragni MV, Thompson A, Ferreira Costa F, Chew AJ, Herzog RW, Arruda VR, Couto LB, McClelland A, Johnson F, Flake AW, Scarsgard E, Armstrong E, Kay M, High KA. A Phase I trial of AAV-mediated muscle directed gene transfer for hemophilia B. Blood 96 Suppl. 1 of 2:801a Abstract 3459, 2000
  65. Shaaban AF, Milner R, Hayashi S, Peranteau WJ, Flake AW. Tolerance induced by in utero hematopoietic stem cell transplantation is required to facilitate higher levels of engraftment with post-natal booster transplants. Blood 96 Suppl. 2 of 2:306b Abstract 5068, 2000
  66. MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves  M, Bouchard S, Wilson JM, Verma IM, Flake AW. Lentiviral vectors in the fetus: Distribution and efficiency is dependent on the route of administration and vector pseudotype. Molecular Therapy 3 No. 5(part 2 of 2):S129 Abstract 367, 2001
  67. Bouchard S, MacKenzie TC, Radu A, Hayashi S, Peranteau BH, Flake AW. Prolonged espression of adenovirus and addeno-associated virus following fetal administration in the preimmune period. Molecular Therapy 3 No. 5(part 2 of 2):S393 Abstract 1121, 2001
  68. Peranteau WH, Hayashi S, Shaaban AF, Flake AW. Engraftment of enriched hematopoietic stem cells (HSC) in the tolerant non-myeloablated allogeneic host: Requirement for facilitation of engraftment despite lack of T-cell mediated alloreactivity. Blood 98 (Suppl. 1 of 2):170a Abstract 715, 2001
  69. Hayashi S, Hsieh M, Peranteau WH, Flake AW. Complete donor chimerism across full allogeneic barriers achieved by in utero hematopoietic stem cell transplantation and prenatal co-transplantation of LLME treated MHC sensitized donor lymphocytes. Blood 98 (Suppl. 1 of 2):170a Abstract 716, 2001
  70. Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. Conversion of minimal allogeneic chimerism to near complete chimerism in tolerant recipients after in utero hematopoietic stem cell transplantation by postnatal non myeloablative total body irradiation (TBI) followed by bone marrow transplantation.  Blood 98 (Suppl. 1 of 2):170a Abstract 717, 2001
  71. Hayashi S, Peranteau WH, Abdulmalik O, Chen Q, Horiuchi K, Asakura T, Flake AW. High level of allogeneic engraftment after postnatal boosting with nonmyeloablative regimen can ameliorate diseases in mixed chimeric hemoglobinopathy mice model after in utero hematopoietic stem cell transplantation. Blood 98 (Suppl. 1 of 2):170a Abstract 718, 2001
  72. Hayashi S, Abdulmalik O, Peranteau WH, Chen Q, Asakura T, Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy: The selective advantage of for donor erythropoiesis is enhanced by fetal liver donor source and shortened red cell half-life. Blood 98 (Suppl. 1 of 2):171a Abstract 719, 2001
  73. Abdulmalik O, Hayashi S, Chen Q, Asakura T, Flake AW. A transgenic mouse model to evaluate the relationship between  levels of mixed chimerism and therapeutic effect in sickle cell disease. Blood 98 (Suppl. 1 of 2):172a Abstract 725, 2001
  74. Hayashi S, Peranteau WH, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism without cytoreductive conditioning or immunosuppression: A combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood 98 (Suppl. 1 of 2):383a Abstract 1611, 2001
  75. MacKenzie TC, Campagnoli C, Almeida-Porada G, Radu A, Fisk N, Flake AW. Circulating human fetal stromal cells engraft and differentiate in multiple tissues following transplantation into preimmune lamb fetuses. Blood 98 (Suppl. 1 of 2):798a Abstract 3319, 2001
  76. Peranteau WH, Hayashi S, Ashizuka S, Hsieh M, Flake AW. Moderate enhancement of allogeneic chimerism following a postnatal cyclophosphamide based transplant regimen in recipients made tolerant by in utero hematopoietic stem cell transplantation . Blood 98 (Suppl. 2 of 2):319b Abstract 5035, 2001
  77. MacKenzie TC, Kobinger GP, Louboutin J-P, Radu A, Wilson JM, Flake AW. Transduction of satellite cells after in utero intramuscular injection of mokola and ebola pseudotyped lentiviral vectors.  Molecular Therapy 5 No. 5(part 2 of 2):S143 Abstract 440, 2002
  78. Louboutin J-P, Kobinger G, MacKenzie TC, Flake AW, Wilson JM. Mokola pseudotyped HIV vector expressing dystrophin can protect mdx mice from exercise induced necrosis of muscle fibers. Molecular Therapy 5 No. 5(part 2 of 2):S145 Abstract 446, 2002
  79. Javazon EH, Sena-Esteves M, Zoltick PW, Beggs KJ, Tebbets J, Flake AW. Multiple factors influence lentiviral transduction efficiency of stem cells. Molecular Therapy 7 No. 5(part 2 of 2): S39 Abstract 98, 2003
  80. Sena-Esteves M, Tebbets JC, Beggs K, Crombleholme TC, Kay EM, Flake AW. Lentivirus mediated gene delivery to the GM1-gangliosidosis mouse brain. Molecular Therapy 7 No. 5(part 2 of 2): S91 Abstract 231, 2003
  81. Zoltick PW, Campagnoli C, Ashizuka S, Flake AW. An improved method for gene transfer to murine hematopoietic progenitor cells using retroviral vectors. Molecular Therapy 7 No. 5(part 2 of 2): S413 Abstract 1070, 2003
  82. Beggs KJ, Campagnoli C, Sullivan KE, Johnson MP, Puck JM, Zanjani ED, Flake AW. Eight years later: T and B-cell function in a patient transplanted in utero for X-linked severe combined immunodeficiency. Blood 102: Abstract 5648, 2003.
  83. Javazon EH, Tebbets JC, Beggs KJ, Sena-Esteves M, Campagnoli C, Radu A, Flake AW. Isolation, expansion, and characterization of murine, adult bone marrow derived, mesenchymal stem cells. Blood 102: Abstract 4437, 2003.
  84. Shaaban AF, Flake AW. Analysis of mature NK Cell Ly49 expression in prenatal chimeras reveals mechanisms of NK tolerance. Blood 102: Abstract 3938, 2003
  85. Hayashi S, Abdulmalik O, Peranteau WH, Chen Q, Horiuchi K, Asakura T, Flake AW. Correction of murine -thalassemia and sickle cell disease across full MHC barriers by in utero hematopoietic cell transplantation followed by postnatal donor lymphocyte infusion. Blood 102: Abstract 3509, 2003
  86. Ashizuka S, Campagnoli C, Hayashi S, Flake AW. Prenatal tolerance induction facilitates post-natal bone marrow transplantation using Busulfan a single conditioning agent. Blood 102: Abstract 1669, 2003.
  87. Abdulmalik O, Hayashi S, Merchant A, Chen Q, Yang J, Asakura T, Flake AW. Complete correction of sickle cell disease pathophysiology in high level allogeneic chimeras created by a strategy of in utero hematopoietic cell transplantation with postnatal enhancement of chimerism. Blood 102: Abstract 928, 2003
  88. Javazon EH, Beggs KJ, Merchant AM, Danzer E, Flake AW. Adult mesenchymal stem cells engraft following in utero transplantation of bone marrow mononuclear cells. Experimental Hematology 32 (Issue 7 Supplement 1):38 (Abstract 29) 2004
  89. Javazon EH, Flake AW. Centrifugation of long bones and a low oxygen environment are optimal conditions for harvesting and expanding adult murine mesenchymal stem cells. Experimental Hematology 32 (Issue 7 Supplement 1):74 (Abstract 175) 2004.
  90. Javazon EH, Zoltick PW, Radu A, Flake AW. Occult karyotypic abnormalities and diverse gene expression profiles in cultured adult murine MSCs. Experimental Hematology 32 (Issue 7 Supplement 1):74 (Abstract 177) 2004.
  91. Merchant AM, Javazon EH, Beggs KJ, Danzer E, Flake AW. Early engraftment kinetics of in utero hematopoietic cell transplantation : Dose dependence and route of administration. Experimental Hematology 32 (Issue 7 Supplement 1):81 (Abstract 201) 2004.
  92. Shaaban AF, Rajesh D, Flake AW. Pattern of Ly49A receptor downregulation in low level prenatal allogeneic chimeras suggests threshold of chimerism needed for long-term engraftment. Blood 104 Part 1: Abstract 1201, 2004
  93. Vemuri MC, Campagnoli C, Beggs KJ, Ashizuka S, Flake AW. Ex-vivo expanded HOXB4-tranduced bone marrow cells enhance allogeneic repopulation in a sublethal irradiation model of BMT. Blood 104 Part 1: Abstract 1203, 2004
  94. Beggs KJ, Javazon EH, Tebbets JC, Flake AW. Evidence of host immune recognition of allogeneic mesenchymal stem cells. Blood 104 Part 1: Abstract 1287, 2004
  95. Peranteau WH, Endo M, Adibe O, Merchant A, Zoltick P, Flake AW. CD26 inhibition enhances allogeneic donor cell homing and engraftment after in utero marrow transplantation. Journal of the American College of Surgeons 201(No. 3S) S44, 2005
  96. Badillo A, Javazon EH, Peranteau WH, Filice S, Flake AW. In utero hematopoietic cell transplantation results in engraftment of donor derived mesenchymal stem cells. Journal of the American College of Surgeons 201(No. 3S) S48, 2005
  97. Tsai A, Filice S, Javazon EH, Badillo A, Flake AW. P21 deficiency augments proliferation of mesenchymal stem cells. Journal of the American College of Surgeons 201(No. 3S) S49, 2005
  98. Danzer E, Layne M, Gorman T, Radu A, Adzick NS, Flake AW. Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development restricted to the eviscerated intestine. Journal of the American College of Surgeons 201(No. 3S) S52, 2005
  99. Adibe OO, Peranteau WH, Endo M, Merchant A, Flake AW. Real time and static in vivo imaging of donor cells after in utero cellular transplantation using the stereoscopic fluorescent microscope. Journal of the American College of Surgeons 201(No. 3S) S89, 2005
  100. Peranteau WH, Endo M, Adibe O, Merchant A, Zoltick P, Flake AW. CD26 inhibition enhances allogeneic donor cell homing and engraftment after in utero bone marrow transplantation. Blood 106:370a (No. 1275), 2005
  101. Badillo AT, Tsai AY,  Flake AW. Intravascular injection of murine mesenchymal stem cells in non-injured neonatal mice results in bone forming nodules within pulmonary vessels. Blood 106:483a (No. 1692), 2005
  102. Tsai AY, Filice SC, Javazon EH, Badillo AT, Flake AW. Absence of P21 gene augments proliferation of mesenchymal stem cells. Blood 106:851a (No. 3039) 2005
  103. Peranteau WH, Badillo AT, Alcorn K, Filice S, Flake AW. Murine mesenchymal stem cells fail to suppress acute graft versus host disease. Blood 106:397b (No. 5253), 2005
  104. Endo M, Zoltick PW, Chang DC, Bennett J, Flake AW. Gene transfer to ocular stem cells by early gestational intra-amniotic injection of lentiviral vector.  Molecular Therapy 13 (Supplement 1):S38 Abstract 92, 2006
  105. Endo M, Coelho TH, Zoltick PW, Flake AW. Developmental stage determines distribution of organ transduction after intra-amniotic injection of lentiviral vector. Molecular Therapy 13 (Supplement 1):S171 Abstract 445, 2006
  106. Endo M, Zoltick PW, Peranteau WH, Ito M, Cotsarelis G, Flake AW. Gene transfer to skin stem cells by early gestational intra-amniotic injection of lentiviral vectors. Molecular Therapy 13 (Supplement 1):S176 Abstract 456, 2006
  107. Danzer E, Radu A, Volpe M, Adzick NS, Flake AW. Normal neuromuscular development of the lower gastrointestinal tract and anorectum in fetal rats with retinoic acid induced myelomeningocele – implications for fetal surgery. Journal of the American College of Surgeons 203 No. 3 (Supplement) Abstract S36, 2006
  108. Peranteau WH, Gu Y, Volk S, Tuschong LM, Bauer TR, Badillo A, Kaye A, Johnson MP, Hickstein DD, Flake AW. In utero hematopoietic cell transplantation using haploidentical parental donors reverses the lethal phenotype in dogs with canine leukocyte adhesion deficiency. Blood  108:188a (No. 624), 2006
  109. Peranteau WH, Endo M, Adibe OO, Flake AW. Evidence for an adaptive immune barrier after in utero hematopoietic cell transplantation. Blood 108:907a (No. 3179), 2006.
  110. Laje P, Peranteau WH, Endo M, Zoltick PW, Flake AW. In utero transplantation of transduced hematopoietic stem cells results in depletion of transgene-specific T cells. Blood 108:932a, 2006.
  111. Niiya M, Endo M, Zoltick PW, Flake AW, Zheng XL. Long term expression of ADAMTS13 at therapeutic levels in mice by in utero administration of lentiviral vectors encoding the human ADAMTS13. Blood 108:936a, (No. 3281), 2006
  112. Tsai AY, Bogdanovich S, Hughes CF, Endo M, Vrecenak J, Traas J, Zoltick PW, Khurana TS, Brazelton T, Flake AW. In utero delivery of adeno-associated virus vector-encoding human mini-dystrophin leads to functional correction in dystrophin deficient mice. Molecular Therapy15 (Supplement 1):S51 Abstract 131, 2007
  113. Endo M, Peranteau WH, Zoltick PW, Radu A, Muvarak N, Flake AW. Ultrasound guided gene transfer to the fetal thymus results in thymic epithelial cell transduction and deletion of transgene specific T-cells. Molecular Therapy15 (Supplement 1):S98 Abstract 256, 2007
  114. Vrecenak JD, Endo M, Zoltick PW, Radu A, Flake AW.Transduction of mammary epithelial stem cell population via early gestational intra-amniotic gene transfer. Molecular Therapy15 (Supplement 1):S109 Abstract 290, 2007
  115. Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Wang Z, Cotsarelis G, Flake AW. The K5 promotor enhances gene expression in stem cell populations after early gestational intra-amniotic gene transfer. Molecular Therapy15 (Supplement 1):S110 Abstract 295, 2007
  116. Laje P, Muvarak N, Zoltick PW, Flake AW. A comparison of transduction efficiency and long-term repopulating capacity of lentiviral transduced SLAM versus KSL enriched HSC using an abbreviated transduction protocol. Molecular Therapy15 (Supplement 1):S112 Abstract 297, 2007
  117. Spivak RM, Endo M, Zoltick PW, Zajac A, Ang BU, Flake AW, Kirschner RE, Nah H-D, In utero delivery of adenovirus encoded TGF-3 rescues cleft palate in a TGF-3 knock-out mouse. Molecular Therapy15 (Supplement 1):S158 Abstract 410, 2007
  118. Endo M, Coelho TH, Zoltick PW, Radu A, Muvarak N, Flake AW. Developmental stage determines distribution of organ transduction after extracoelomic cavity injection of lentiviral vector. Molecular Therapy15 (Supplement 1):S265 Abstract 691, 2007
  119. Merianos DJ, Tiblad E, Laje P, Endo M, Zoltick PW, Flake AW. Characterization of the adaptive immune response to in utero hematopoietic cell transplantation. Journal of the American College of Surgeons 207 No. 3 (Supplement) Abstract S70, 2008
  120. Vrecenak JD, Endo M, Zoltick PW, Muvarak N, Radu A, Flake AW. Efficient Transduction of Mammary Epithelial Stem Cells by Early Gestational Intra-amniotic Gene Transfer Using Lentiviral Vector. Journal of the American College of Surgeons 207 No. 3 (Supplement) Abstract S72, 2008
  121. Stitelman D, Endo M, Zoltick PW, Brazelton T, Flake AW. Gene Transfer to Progenitor Cells of the Central Nervous System by Early Intra-amniotic Delivery of Lentiviral Vector. Journal of the American College of Surgeons 207 No. 3 (Supplement) Abstract S103, 2008
  122. Heaton TE, Peranteau WH, Bauer TR, Zoltick PW, Hickstein DD, Flake AW. High level chimerism and donor specific tolerance achieved in the canine model by in utero hematopoietic cell transplantation followed by postnatal minimal conditioning bone marrow transplantation. Journal of the American College of Surgeons 207 No. 3 (Supplement) Abstract S105, 2008
  123. Merianos DJ, Tiblad E, Laje P, Endo M, Zoltick PW, Flake AW. Breast milk transmission of maternal alloantibodies activates a prenatal immune response that limits allogeneic engraftment after in utero hematopoietic stem cell transplantation in the murine model. Blood 112:140, (Abstract #362), 2008
  124. Laje P, Shang D, Cao W, Niija M, Endo M, Radu A, DeRogatis N, Scheiflinger F, Zoltick PW, Flake AW, Zheng XL, Correction of ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy. Blood 112:821 (Abstract #2356) 2008
  125. Stitelman DH, Endo M, Zoltick PW, Flake AW, Brazelton T. Efficient gene transfer to central nervous system progenitor cells by early intra-amniotic delivery of lentiviral vector. Molecular Therapy 17 (Supplement 1):S22 Abstract 55, 2009
  126. Roybal JL, Endo M, Stitelman DH, Radu A, Spitz B, Zoltick PW, Flake AW. Targeted transduction of hepatic progenitor cells after early in utero gene transfer. Molecular Therapy 17 (Supplement 1):S74 Abstract 189, 2009
  127. Endo M, Otsuru S, Zoltick PW, Hofmann TJ, Radu A, Horwitz EM, Flake AW. Gene transfer to the skeletal system by early intra-cardiac injection of lentiviral vector driven by the Col1A1 promotor. Molecular Therapy 17 (Supplement 1):S77 Abstract 196, 2009
  128. Endo M, Laje P, Stitelman DH, Kim AG, Roybal JL, Radu A, Zoltick PW, Flake AW. In situ transduction of hematopoietic stem cells by early gestational intra-cardiac injection of lentiviral vector. Molecular Therapy 17 (Supplement 1):S116 Abstract 299, 2009
  129. Endo M, Zoltick PW, Qiujie J, Matsui C, Uitto J, Flake AW. Reprogramming basal keratinocytes to express deficient protein after intra-amniotic gene transfer in a murine model of junctional epidermolysis bullosa. Molecular Therapy 17 (Supplement 1):S153 Abstract 392, 2009
  130. Stitelman DH, Bora A, Traas J, Merianos DJ, Flake AW, Brazelton T. Efficient gene transfer to muscle satellite cells by in utero intravenous delivery of adeno-associated virus vector. Molecular Therapy 17 (Supplement 1):S153 Abstract 393, 2009
  131. Stitelman DH, Roybal JL, Endo M, Zoltick PW, Flake AW, Brazelton T.  Gene expression in astrocytes and adult neural progenitor cells in vivo by early in utero delivery of lentivirus and a GFAP promotor. Molecular Therapy 17 (Supplement 1):S196 Abstract 510, 2009
  132. Kim AG, Endo M, Zoltick PW, Radu A, Flake AW. Gene expression limited to pancreatic islet cells after early gestational extra-coelomic gene transfer of lentiviral driven by the rat insulin promotor. Molecular Therapy 17 (Supplement 1):S380 Abstract 998, 2009
  133. Heaton TE, Santore MT, Merianos DJ, Quinn C, Zoltick PW, Hickstein DD, Flake AW. High doses of CD3+ cells enhance hematopoietic chimerism and donor-specific tolerance in the canine model of in utero hematopoietic cell transplantation. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S59, 2009
  134. Watanabe M, Tataba Y, Jo J, Flake AW, A tissue engineering approach for prenatal closure of myelomeningocele. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S62, 2009
  135. Danzer E, Zhang L, Watanabe M, Bebbington MW, Radu A, Liechty KW, Adzick NS, Flake AW. Amniotic fluid levels of glial fibrillary acid protein in fetal rats with retinoic acid-induced myelomeningocele: a potential marker for spinal cord injury. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S63, 2009
  136. Marianos DJ, Tiblad E, Santore MT, Todorow CA, Zoltick PW, Flake AW. Regulatory T cells may prevent loss of engraftment after in utero hematopoietic cell transplantation. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S84, 2009.
  137. Quinn C, Merianos DJ, Endo M, Flake AW. Adoptive transfer of minor histocompatability antigen H60-specific T cells enhances engraftment after allogeneic in utero stem cell transplantation. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S84, 2009
  138. Stitelman DH, Bora A, Traas J, Merianos DJ, Flake AW, Brazelton T. Efficient gene transfer to muscle satellite cells by in utero intravenous delivery of adeno-associated viral vector. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S124, 2009
  139. Roybal JL, Endo M, Radu A, Spitze BA, Zoltick PW, Flake AW. Early gestational gene-transfer with lentiviral vector driven by a liver-specific promotor targets the fetal liver and improves phenotype in a murine model of Wilson’s disease. Journal of the American College of Surgeons 209 No. 3 (Supplement) Abstract S124, 200
  140. Endo M, Zoltick PW, Radu A, Qiujie J, Matsui C, Marinkovich PM, Uitto J, Flake AW. Long-term phenotypic correction of skin by fetal gene transfer in a lethal murine model of Epidermolysis Bullosa.
  141. Roybal JL, Endo M, Radu A, Todorow C, Zoltick PW, Flake AW. Early gestational gene transfer of IL10 by lentiviral vector can prevent arthritis in a murine model. Molecular Therapy 18 (Supplement 1):S133 Abstract 344, 2010.
  142. Roybal JL, Endo M, Radu A, Todorow C, Zoltick PW, Flake AW. Early gestational gene-transfer with lentiviral vector driven by a liver-specific promotor targets the fetal liver and improves phenotype in a murine model of Wilson’s disease. Molecular Therapy 18 (Supplement 1):S264 Abstract 676, 2010.
  143. Santore MT, Merianos DJ, Todorow CA, Endo M, Flake AW. In the absence of an adaptive immune response, NK cells do not limit engraftment after in utero hematopoietic stem cell transplantation. Journal of the American College of Surgeons 211 No. 3 (Supplement) Abstract S63, 2010
  144. Santore MT, Merianos DJ, Todorow CA, Flake AW. Elimination of the maternally induced adaptive immune response allows uniform achievement of high-level allogeneic chimerism by in utero hematopoietic cellular transplantation. Journal of the American College of Surgeons 211 No. 3 (Supplement) Abstract S92, 2010
  145. Roybal JI, Endo M, Radu A, Todorow CA, Zoltick PW, Flake AW. Early gestational gene transfer of IL-10 by lentiviral vector can prevent arthritis in a murine model. Journal of the American College of Surgeons 211 No. 3 (Supplement) Abstract S124, 2010
  146. Watanabe M, Vrecenak J, Tsai J, Sulkowski J, Timpo E, Li H, Flake AW. Acute GVHD induced by in utero hematopoietic cell transplantation is reversed by a regulatory response resulting in a potent Graft vs. Hematopoietic effect without clinical GVHD. Blood 118: (Abstract #1904), 2011
  147. Vrecenak JD, Santore MT, Todorow CA, Alcorn KA, Li H, Johnson MP, Flake AW. Consistent achievement of improved levels of hematopoietic chimerism in the canine model following optimization of haploidentical in utero transplantation. Blood 118 (Abstract #2962) 2011
Editorials, Reviews, Chapters
  1. Adzick NS, Harrison MR, Glick PL, Flake AW: Fetal urinary tract obstruction and  experimental pathophysiology.  Seminars in Perinatology 9:79-90,1985.
  2. Adzick NS, Flake AW:  Recent advances in prenatal diagnosis and treatment.  Pediatric Clinics of North America 32:1103-1116, 1985.
  3. Adzick NS, Harrison MR, Flake AW:  Experimental studies on prenatal treatment of congenital anomalies. British Journal of Hospital Practice pp 154-159, Sept. 1985.
  4. Anderson WF, Kantoff P, Eglitis M, McLachlin J, Karson E, Zweibel J, Nienhuis A, Karlsson S, Blaese RM, Kohn D, Gilboa E, Armentano D, Zanjani ED, Flake AW, Harrison MR, Gillio A, Bordignon C, O"Reilly R. Gene transfer and expression in nonhuman primates using retroviral vectors. Cold Springs Harbor Symposia on Quantitative Biology 51:1073-1081, 1986
  5. Kuhlman RS, Warsof SL, Levy D, Flake AW:  Fetal sacrococcygeal teratoma. Fetal Diagnosis and Therapy 2:95-100 1987.
  6. Eglitis MA, Kantoff PW, McLachlin JR, Gillio A, Flake AW:  Gene therapy: efforts at developing large animal models for  autologous bone marrow transplant and gene transfer with retroviral vectors.  Ciba Foundation Symposium 130:229-246 1987.
  7. Flake AW, Adzick NS, Glick PL, Harrison MR: Evaluation of the fetus with hydronephrosis.  New Technologies in Urology, deVere-White RW and Palmer JM, (eds.), Futura Publications, New York, Chapter 17, 1987.
  8. Flake AW, Adzick NS, Harrison MR:  Intrauterine intervention; fetal surgery in the nonhuman primate.  Non Human primates in Perinatal Research, Brans YW and Kuehl Tj, (eds.), John Wiley and Sons, New York, Chapter 14, 1988.
  9. Flake AW, Harrison MR: Experimental malformations and their correction.  Fetal Medicine, Volume 1, Rodeck CH, (ed.), Blackwell Scientific Publications, London, Chapter 5, pp 90-117, 1989.
  10. Holzgreve W, Flake AW, Langer JA: Fetal sacrococcygeal teratoma.  The unborn patient.  Prenatal diagnosis and Treatment, 2nd Edition, Harrison MR, Golbus MS, Filly RA, (eds.), W.B. Saunders Co., Orlando, Fl, Chapter 39, 1990.
  11. Flake AW, Harrison MR, Zanjani ED:  Transplantation of hematopoietic stem cells in-utero. Experimental Hematology 19:1061-1064, 1991.
  12. Ryckman FC, Flake AW, Balistreri WF:  Upper gastrointestinal disorders.  Neonatal-Perinatal  Medicine. Fifth Edition, Fanaroff AA, Martin RJ, (eds.) Chapter 41, Part 2, Mosby-Year Book  Inc., pp. 1024 -30, 1992.
  13. Flake AW, Ryckman FC: Selected Anomalies and Intestinal Obstruction.” Neonatal-Perinatal Medicine. Edition, Fanaroff AA, Martin RJ, (eds) Chapter 41, Part 4, Mosby-Year Book Inc., pp. 1038-66, 1992.
  14. Crissenger KD, Ryckman FC, Flake AW, Balistreri WF: Necrotizing enterocolitis.  Neonatal-Perinatal Medicine. Fifth Edition, Fanaroff AA, Martin RJ, (eds.) Chapter 41, Part 6, Mosby-Year Book Inc., pp. 1068-73, 1992.
  15. Flake AW, Harrison MR, Zanjani ED: In Utero Transplantation of Hematopoietic Stem Cells. Critical Reviews in Oncology/Hematology 15-35-48, 1993.
  16. Flake AW:  Fetal sacrococcygeal teratoma.  Seminars in Pediatric Surgery 2:113-120, 1993.
  17. Harrison MR, Adzick NS, Flake AW: Congenital diaphragmatic hernia: an unsolved problem.  Seminars in Pediatric Surgery 2:109-112, 1993.
  18. Flake AW, Zanjani ED: In-utero transplantation of hematopoietic stem cells.  Critical Reviews in Oncology/Hematology 15:35-48, 1993.
  19. Flake AW: Ontogeny of fetal immunity. In infections and immunologic problems in pediatric surgical patients.  Fonkalsrud EW, (ed.) WB Saunders Co., Orlando, Fl, Chapter 3, pp. 9-21, 1993.           
  20. Flake AW, Harrison MR: Fetal therapy-medical and surgical approaches.  In Maternal and Fetal Medicine. Third Edition, Creasy, RK ed. Chapter 25, pp 370-381, 1994.
  21. Harrison MR, Adzick NS, Flake AW: The prenatal management of the fetus with a correctable defect. In Ultrasonography in Obstetrics and Gynecology, Third Edition, Callen, P ed. Chapter 21, pp 536-547, 1994.
  22. Zanjani, ED, Silva, MR, Flake AW. Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras. Blood Cells 20:331-338, 1994
  23. Evans, MI, Adzick NS, Johnson MP, Flake AW: Fetal therapy - 1994.  Current Opinion in Obstetrics  and  Gynecology 6:58-64, 1995.
  24. Flake AW, Harrison MR: Fetal surgery.  Annual Review of Medicine 46:67-78, 1995.
  25. Zanjani ED, Almeida-Porada G, Flake AW: Engraftment and multilineage expression of human hematopoietic stem cells in human-sheep chimeras.  Stem Cells 13:101-111, 1995.
  26. Zanjani ED, Flake AW: In utero hematopoietic stem cell transplantation.  Sickle Cell Disease and Thalassaemias: New Trends in Therapy, Eds. Beuzard Y Lubin B, Rosa J. 234:597-603, 1995.
  27. Flake AW: In utero hematopoietic stem cell transplantation.  Diseases of the Fetus and Newborn, Second Edition, Reed G, Glaireaux A, Cockburn F, and Connor M (eds.), Chapter 88, Chapman & Hall  Medical , pp. 1331-1335, 1995.
  28. Almeida-Porada G, Flake AW, Porada C, Ruthven J, Ruthven J, Zanjani ED. Human stem cell engraftment in sheep. Proceedings of the Conference on Ontogeny of Hematopoiesis: Aplastic Anemia. Gluckman G and Coulombel L (eds.) John Libbey. Inserm 235:89-95, 1995
  29. Johnson MP, Flake AW: Modifications of technique based on hard lessons learned.  Dialogues in Pediatric Urology-Advances in Fetal Therapy for Obstructive Uropathy 19(4):5, 1996.
  30. Zanjani ED, Almeida-Porada GD, Flake AW. The human/sheep xenograft model:
    a large animal model of human hematopoiesis.  International Journal of Hematology.  63:179-192, 1996
  31. Flake AW: Is a ct guided needle better than a knife?  Invited Editorial in Pediatric Pulmonology 22:83-84,1996          
  32. Flake AW: Fetal surgery for congenital diaphragmatic hernia.  Seminars in Pediatric Surgery 5:266-274, 1996.
  33. Johnson MP, Flake AW, Quintero RA, Evans MI: Fetal Shunt Procedures.  In Invasive Outpatient Procedures in Reproductive Medicine. Evans MI, Johnson MP, and Moghissi KS (eds.)  Lippencott-Raven Publishers. Philadelphia. pp. 61-90, 1997.
  34. Flake AW: Disorders of the biliary tract. In Surgery of Infants and Children: Scientific Principles and Practice. Oldham KT, Fogila RP, Colombani PM, (eds), Lippencott-Raven Publishers, Philadelphia, PA Chapter 87, pp. 1405-1414, 1997
  35. Flake AW, Zanjani ED: Cellular therapy.  New Trends and Controversies in Fetal Diagnosis and Therapy. Reece EA (eds.), Obstetrics and Gynecology Clinics of North America. 24:159-177, 1997.
  36. Zanjani ED, Almeida-Porada GD, Ascensao JL, MacKintosh FR, Flake AW. Transplantation of hematopoietic stem cells in utero. Stem Cells 15(Supple. 1):79-93, 1997
  37. Flake AW, Quintero RA, Johnson MP, Evans MI. Fetal Surgical Intervention. in Surgical Technology International VI pp.171-176, 1997
  38. Zanjani ED, Almeida-Porada G, Porada C, Flake AW. In utero approach to hematopoietic stem cell transplantation. COGENT IV:137-150, 1997
  39. Evans MI, Flake AW, Harrison MR, Quintero RA, Johnson MP. Fetal Therapy. In Genetic Disorders and the Fetus, 5th edition, Milunsky A (ed.), The John Hopkins University Press, Baltimore, MD. Chapter 29, pp952-98, 1998
  40. Ryckman FC, Flake AW, Balistreri WF: Upper gastrointestinal disorders.  Neonatal-Perinatal  Medicine. Diseases of the Fetus and Infant, Sixth Edition, Fanaroff AA, Martin RJ, (eds.) Chapter 44, Part 2, Mosby-Year Book  Inc., pp. 1294 -98, 1998.
  41. Flake AW, Ryckman FC: Selected Anomalies and Intestinal Obstruction.” Neonatal-Perinatal Medicine. . Diseases of the Fetus and Infant, Sixth Edition, Fanaroff AA, Martin RJ, (eds.) Chapter 44, Part 2, Mosby-Year Book  Inc., pp. 1307 -30, 1998.
  42. Flake AW, Howell LJ: Fetal Surgery. Pediatric Surgery and Urology: Long-term Outcomes. Stringer MD (eds.) , W. B. Saunders Company, London, Chapter 64, pp. 797-805, 1998
  43. Flake AW: Fetal Therapy: Medical and Surgical Approaches.  In Maternal and Fetal Medicine. Fourth Edition, Creasy, RK and Resnick R, (eds.) W.B. Saunders Company, Philadelphia, PA.  Chapter 24, pp. 365-378, 1998
  44. Flake AW,  Zanjani ED. Fetal Stem Cell Therapy. In Medicine of the Fetus and Mother. Second Edition. Reece EA, Hobbins J (eds.), Lippincott-Raven Publishers, Philadelphia, Chapter 50, pp. 891-902, 1998
  45. Flake AW: Treatment of X-linked Severe Combined Immunodeficiency by the in utero transplantation of hematopoietic stem cells: Case report. In Stem Cell Therapy of Inherited Hematopoietic Disorders. Migliaccio AR and Alessandrini L (eds.)  Instituto Superiore Di Sanita, Rapporti ISTISAN, pp 47-51, 1998
  46. Johnson MP, Flake AW, Harrison MR, Quintero R, Evans MI. In Utero Therapy of the Fetus. In Principles and Practice of Medical Therapy in Pregnancy: Third Edition. Gleicher N, Buttino L Jr.,  Elkayam U, Evans MI, Galbraith RM, Gall SA,  and Sabai BM (eds.), Appleton & Lange, Stamford, CT. Chapter 43: 370-376, 1998.
  47. Flake AW: In utero hematopoietic stem cell transplantation.  Fetal Medicine: Basic Science and Clinical Practice.  Rodeck CH and Whittle MJ (eds.), Harcourt Brace & Co. Ltd. , London, Chapter 67, pp. 887-898, 1999.
  48. Flake AW, Crombleholme TM, Adzick NS: The Current Status and Future Potential of Fetal Intervention: Image is Everything. Computerized Medical Imaging and Graphics. 23:51-57, 1999
  49. Flake AW, Zanjani ED. In Utero Transplantation. In Hematopoietic Cell Transplantation.  Second Edition. Forman SJ, Bloom KG, and Thomas ED (eds), Blackwell Science Inc., Malden, MA, Chapter 42, pp. 444-454, 1999
  50. Evans MI, Flake AW, Johnson MP, Holzgreve W, Harrison MR. Fetal Therapy. In Neonatology. Pathophysiology and Management of the Newborn.  Fifth Edition. Avery GB, Fletcher MA, and MacDonald MG (eds), Lippincott Williams & Wilkins, Philadelphia, Chapter 13, pp. 173-186, 1999
  51. Flake AW, Zanjani ED. Treatment of Severe Combined Immunodeficiency. Letter to the Editor. New England Journal of Medicine 341: 291, 1999
  52. Flake AW. In Utero Stem Cell Transplantation for the Treatment of Genetic Diseases. Congress Report. Schweizerische Medizinische Wochenschrift (Swiss Medical Weekly)
    129:1733-1739, 1999
  53. Shaaban AF, Flake AW. Fetal Hematopoietic Stem Cell Transplantation. In Fetal Therapy for the 21st Century, Adzick NS (guest editor) Seminars in Perinatology, 23:515-523, 1999
  54. Kitano Y, Flake AW, Crombleholme TM, Johnson MP, Adzick NS. Open Fetal Surgery for Life-threatening Fetal Malformations. In Fetal Therapy for the 21st Century, Adzick NS (guest editor) Seminars in Perinatology, 23:448-461, 1999
  55. Yang EY, Flake AW, Adzick NS.  Prospects for fetal gene therapy. In Fetal Therapy for the 21st Century, Adzick NS (guest editor) Seminars in Perinatology 23:524-534,1999
  56. Flake AW. In Utero Stem Cell Transplantation. The Virtues of Tolerance. In Pediatric Surgery: Masters and Frontiers. MD Klein (Editor) Children's Hospital of Michigan,
    2000.
  57. Flake AW: Fetal sacrococcygeal teratoma.  Progress in Obstetrics and Gynecology - Sonography Series, Ultrasound and Fetal Therapy Rodeck CH and Evans MI (eds.), Parthenon Press, Chapter 4, pp. 39-48, 2000.
  58. Yaron Y, Flake AW, Zanjani ED, Johnson MP, Evans MI: Stem Cell Fetal Therapy.  Progress in Obstetrics and Gynecology - Sonography Series, Ultrasound and Fetal Therapy Rodeck CH and Evans MI (eds.), Parthenon Press, Chapter 9, pp. 105-112, 2000.
  59. Flake AW, Zanjani ED. Response: Role of the alloimmune response after in utero hematopoietic stem cell transplantation. (letter) Blood 96:1608-9, 2000 
  60. Flake AW. The Fetus with Sacrococcygeal Teratoma.  The Unborn Patient.  The Art  and Science of Fetal Therapy, 3rd Edition, Harrison MR, Evans MI, Adzick NA, Holtzgreve W, (eds.), W.B. Saunders Co., Orlando, Fl, Chapter 21, pp.315-324, 2001
  61. Flake AW. The Fetus with a Hematopoietic Stem Cell Defect. The Unborn Patient.  The Art  and Science of Fetal Therapy, 3rd Edition, Harrison MR, Evans MI, Adzick NA, Holtzgreve W, (eds.), W.B. Saunders Co., Orlando, Fl, Chapter 37, pp.591-604, 2001
  62. MacKenzie TC, Flake AW. New Adventures in Prenatal Therapy: In Utero MSC Transplantation. GRAFT 3:315-318, 2000
  63. Flake AW. Fate Mapping of Stem Cells. In “Stem Cells”. Cold Spring Harbor Monograph Series. Marshak D,  Gardner R., Gottlieb D. (eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY,  Chapter 17, pp. 375-398 2001
  64. Evans MI, Harrison MR,Flake AW, Johnson MP. Fetal Therapeutic Intervention. In “Obstetrics. Normal and Problem Pregnancies”4th Edition. Gabbe SG, Niebyl JR, and Simpson JL (eds) Churchill Livingston Publishers, Philadelphia, PA, Chapter 11, pp. 297-312, 2001.
  65. MacKenzie TC, Flake AW. Human Mesenchymal Stem Cells Persist, Demonstrate Site-Specific Multipotential Differentiation, and are Present in Sites of Wound Healing and Tissue Regeneration after Transplantation into Fetal Sheep. Blood Cells, Molecules, and Diseases 27:601-4, 2001
  66. Hayashi S, Flake AW. In Utero Hematopoietic Stem Cell Therapy. Yonsei Medical Journal 42:615-29.2001
  67. Flake AW. In Utero Transplantation of Haemopoietic Stem Cells. In “New Aspects of Stem Cell Transplantation” Russell NH editor, Balliere’s Best Practice & Research: Clinical  Haematology 14:671-83, 2001
  68. MacKenzie TC, Flake AW. Human Mesenchymal Stem Cells. Insights from a Surrogate  In Vivo Assay System. Cells, Tissues, and Organs. 171:90-95,  2002
  69. Flake AW. Genetic Therapies for the Fetus. Clinical Obstetrics and Gynecology 45:684-696, 2002
  70. MacKenzie TC, Crombleholme TM, Flake AW. The Ex Utero Intrapartum Treatment Procedure . Current Opinions in Pediatrics, 14:453-458, 2002
  71. Evans MI, Harrison MR, Flake AW, Johnson MP. Fetal Therapy. Best Pract Res Clin Obstet Gynaecol 16:671-83, 2002
  72. Pittenger M, Flake AW, Deans RD. Stem Cell Culture: Mesenchymal Stem Cells from Adult Bone Marrow. In “Methods of Tissue Engineering” Atala A., Lanza R. (eds.) Academic Press, San Diego, CA Chapter 38, pp. 461-471, 2002
  73. Shaaban AF, Kim HB, Flake AW. Fetal Surgery, Diagnosis and Intervention. Operative Pediatric Surgery. Ziegler MM, Azizkhan RG, Gauderer MWL (eds) Appleton & Lange, Stamford, CT,  Chapter 3, pp. 21-35, 2003
  74. Adzick NS, Flake AW, Crombleholme TM. Management of congenital lung lesions. Seminars in Pediatric Surgery 12:10-16, 2003
  75. Flake AW. Surgery in the human fetus: the future. Journal of Physiology 547(Pt 1):45-51, 2003
  76. Flake AW. Stem Cell and Genetic Therapies for the Fetus. Seminars in Pediatric Surgery. 12:202-208, 2003
  77. Evers BM, Weissman IL, Flake AW, Tabar V, Weisel RD. Stem Cells in Clinical Practice. Journal of the American College of Surgeons, 197:458-78, 2003.
  78. Flake AW: Fetal Therapy: Medical and Surgical Approaches.  In Maternal and Fetal Medicine. Fifth Edition, Creasy, RK and Resnick R, (eds.) Iams JD (Associate ed.) W.B. Saunders Company, Philadelphia, PA.  Chapter 27, pp. 483-494, 2003
  79. MacKenzie TC, Flake AW. Congenital Lung Lesions. In “Surgical Directives” Editor P. Mattei, Chapter 86, 481-485, Lippincott, Williams, & Wilkins, Philadelphia, 2003
  80. Flake AW, Zanjani ED. In Utero Transplantation.  In Thomas’ Hematopoietic Cell Transplantation.  Third  Edition. Forman SJ, Bloom KG, Applebaum FR (eds), Chapter 44, pp. 565-575, Blackwell Science Inc., Malden, MA, , 2004. 
  81. Peranteau WH, Hayashi S, Kim HB, Shaaban AF, Flake AW. In utero hematopoietic cell transplantation: What are the important questions? Fetal Diagnosis and Therapy 19: 9-12, 2004
  82. Flake AW. In Utero Hematopoietic Cell Transplantation. In “Stem Cells in Obstetric and Gynaecology” Best Practice & Research Clinical Obstetrics & Gynaecology Series. Fisk NM and Itskovitz (guest editors)18:941-958, 2004.
  83. Flake AW. Cell/Gene Transplant. In Surgery of Infants and Children: Scientific Principles and Practice. Oldham KT, Fogila RP, Colombani PM, (eds), 2nd Edition, Chapter 51, pp. 793-805, Lippencott-Raven Publishers, Philadelphia, PA, 2005
  84. Flake AW, Adzick NA, Johnson MP, Sutton L. Fetal Surgery for Myelomeningocele. Journal of the Japan Society of Perinatal and Neonatal Medicine 41:649-653, 2005
  85. Flake AW. Laparotomy versus Drainage in Premature Infants. New England Journal of Medicine 354:2275-2276 2006
  86. Peranteau WH, Flake AW. In Utero Tolerance. Current Opinion in Organ Transplantation 11:353-359, 2006
  87. Flake AW. Molecular Clinical Genetics and Gene Therapy. In Pediatric Surgery, Grosfeld JL, O’Neall JA, Fonkalsrud EW, Coran AG (eds) 6th Edition, Chapter 2, pp. 11-20, Mosby, Philadelphia, PA,  2006
  88. Kim HB, Shaaban AF, Flake AW. Fetal Genetic Therapy - Stem Cells. In Prenatal Diagnosis: Genetics, Reproductive Risks, Testing, and Management.  Evans MI, Johnson MP, Yaron Y, Drugan A (eds), Chapter 63,  pp. 691-698, Appleton & Lange, Stamford, CT., 2006.
  89. Li W and Flake AW. Stem Cell Biology. In The Renaissance of Sickle Cell Disease in the Human Genome Era, Chap 16, pp. 259-271, Imperial College Press. UK, 2007
  90. Badillo AT, Flake AW. The Regulatory Role of the Stromal Microenvironment in Fetal Hematopoietic Ontogeny. Stem Cell Reviews 2:241-246, 2006
  91. Evans MI, Yaron Y,  Deprest J,Flake AW, Kleinman C   and Harrison MR. Fetal Therapy. In Obstetrics: Normal and Problem Pregnancies. Fifth Edition. Gabbe SG, Niebyl JR, and Simpson JL (eds.), Chapter 10, pp. 245-266, Churchill Livingston Elsevier, Philadelphia 2007
  92. Danzer E, Flake AW. In utero repair of myelomeningocele: rationale, initial clinical experience and a randomized controlled prospective clinical trial. Neuroembryology and Ageing, 4:165-174, 2006/2007
  93. Liechty KL, Flake AW. Pulmonary Vascular Malformations. Seminars in Pediatric Surgery, 17:9-16, 2008
  94. Merianos DJ, Heaton T, Flake AW. In Utero Hematopoietic Stem Cell Transplantation: Progress toward clinical application. Biology of Blood and Marrow Transplantation 14:729-740, 2008
  95. Heaton TE, Flake AW. Peritoneal Drain vs. Laparotomy for the Surgical Management of NEC in the Extremely Premature Infant. In Nutritional Care of the Preterm Infant. Editor; Gilbert Pereira, Chapter 14, pp. 225-240, Medbook Scientific Editors, Ltd. Rio de Jeneiro, 2008
  96. Quinn C, Flake AW. In Vivo Differentiation Potential of Mesenchymal Stem Cells. Prenatal and Postnatal Model Systems. Transfusion and Hematotherapy, 35, 239-248, 2008
  97. Flake AW. Open Surgery for Fetal Sacrococcygeal Teratoma. In Fetal Therapy: State of the Art. Evans MI and Platt L (eds) Parthenon Publishing, Lancaster, UK. (in press) 2004
  98. Flake AW, Hedrick HL. Congenital Diaphragmatic Hernia. In Fetal Medicine: Basic Science and Clinical Practice.  Rodeck CH and Whittle MJ (eds.), Elsevier Limited, Edinburgh, UK, Chapter 30. 437-446, 2009.
  99. Flake AW, Zanjani ED. In Utero Transplantation.  In Thomas’ Hematopoietic Cell Transplantation.  Fourth  Edition. Forman SJ, Bloom KG, Applebaum FR (eds), Chapter 40, pp577-589, Blackwell Science Inc., Malden, MA,  2007.
  100. Flake AW, Fixing Bones Before Birth. “Inside Blood” Blood 111:978-979, 2008
  101. Chiu B, Flake AW. Congenital Lung Anomalies. In “Fundamentals of Pediatric Surgery” Editor P. Mattei, Chapter 37, 293-298, Springer, New York, NY, 2011
  102. Minneci PC, Flake AW. Biliary Atresia. In “Fundamentals of Pediatric Surgery” Editor P. Mattei, Chapter 73, 567-574, Springer, New York, NY, 2011
  103. Santore MT, Roybal J, Flake AW. Prenatal Stem Cell and Gene Therapy, Clinics in Perinatology, 36:451-471, 2009
  104. Roybal J, Santore MT, Flake AW. Stem Cell and Genetic Therapies for the Fetus, Advances in Fetal Surgery Edition, Seminars in Neonatal and Fetal Medicine, 15:46-51 2010
  105. Watanabe M, Flake AW.  Fetal Surgery: Progress and Perspectives. Advances in Pediatrics, 57:353-372, 2010
  106. Deprest JA, Flake AW, Gratacos E, Ville Y, Hecher K, Nicolaides K, Johnson MP, Luks FI, Adzick NS, Harrison MR. The Making of Fetal Surgery, Prenatal Diagnosis 30:653-667, 2010
  107. Davey M, Flake AW. Genetic Therapies for the Fetus: A Once in a Lifetime Opportunity. Human Gene Therapy 4:383-385, 2011
  108. Flake AW. Molecular Clinical Genetics and Gene Therapy. In Pediatric Surgery, Grosfeld JL, Coran AG, Adzick NS (eds) 7th Edition, Chapter 2, Mosby, Philadelphia, PA,  In Press, 2011
  109. Vrecenak JD, Flake AW. Fetal Surgery, Diagnosis, and Intervention. Operative Pediatric Surgery. Ziegler MM, Azizkhan RG, Gauderer MWL (eds) McGraw Hill Publishers, Baton Rouge, LA,  Chapter 3, 2011
  110. Flake AW. Principles of Maternal-Fetal Surgery. Operative Pediatric Surgery, 7th Edition. Spitz L. Coran A. (eds) Pierro A. Teitelbaum D, Tan H. (co-eds), Chapter 105. Hodder & Stoughton Limited, London, 2011
  111. Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of Manipulated Stem Cells for Prenatal Therapy. In “Prenatal Gene Therapy” Coutelle C and Waddington S(eds) Chapter 8. Methods in Molecular Biology, 2012
  112. Roybal JL, Endo M, Buckley SMK, Herbert BR, Waddington SN, Flake AW. Animal Models for Prenatal Gene Therapy: The Rodent Model. In “Prenatal Gene Therapy” Coutelle C and Waddington S(eds) Chapter 10. Methods in Molecular Biology, 2012
  113. Abi-Nader KN, Boyd M, Flake AW, Mehta V, Peebles D, David AL. Animal Models for Prenatal Gene Therapy: The Sheep Model. In “Prenatal Gene Therapy” Coutelle C and Waddington S(eds) Chapter 11. Methods in Molecular Biology, 2012
  114. Flake AW and Adzick NS. Fetal Surgery. In Rickham’s Neonatal Surgery, 4th Edition, Losty PD, Rintala RJ, Flake AW, Hutson JM, Iwai N (eds), Springer Publishers Ltd. 2012
  115. Partridge EA, Flake AW. Maternal Fetal Surgery for Structural Malformations, Advances in fetal genetic diagnosis and therapy; Choolani M and Biswas A (Guest eds) Best Practice & Research Clinical Obstetrics and Gynecology; Elsevier Health Sciences, Amsterdam, 2012.
  116. Nijagal A, Flake AW, MacKenzie TC. In Utero Hematopoietic Cell Transplantation for Treatment of Congenital Anomalies, in Surgical Advances in the Fetus and Neonate, Clinics of Perinatology, Lee H and Hirschl RB (eds) Elsevier Health Sciences, 2012
Video Presentations
  1. Harrison MR, Adzick NS, Flake AW. A Womb with a View: Exposing the Fetus. Video Presentation at the 23rd annual meeting of the American Pediatric Surgical Association. Colorado Springs, Colorado, May 14th 1992
  2. Flake AW, Johnson MP, et.al. Successful in utero treatment of congenital diaphragmatic hernia (CDH) by prenatal tracheal occlusion. Video presentation at  the Motion Picture Exhibit , American College of Surgeons, San Francisco, CA, October 7th, 1996
  3. Deans KW, Blinman TA, Flake AW. Laparoscopic resection of Choledochal Cyst: Reconstruction by Hepaticoduodenostomy. 41st annual meeting of the American Pediatric Surgical Association, Orlando, FL May 16th, 2010

Dr. Alan Flake

 
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