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W. Clark Hargrove, III, M.D.
Cardiovascular Surgery

 
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  • Memberships
  • Research
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Administrative Office:
Presbyterian Medical Center
Heart & Vascular Pavilion, Suite 2A
51 North 39th Street
Philadelphia, PA 19104
Administrative Assistant: Michele Bernstein
Administrative Telephone: 215-662-9595
Administrative Fax: 215-243-3243
Patient Appointments: 215-662-9595

Clinical Office:
Presbyterian Medical Center
Heart & Vascular Pavilion, Suite 2A
51 North 39th Street
Philadelphia, PA 19104
Clinical Telephone: 215-662-9595
Clinical Fax: 215-243-3243
Patient Appointments: 215-662-9595

Contact Information (internal use only)

clark.hargrove@uphs.upenn.edu

 

Dr. Hargrove is a Clinical Professor in the Division of Cardiovascular Surgery at the University of Pennsylvania School of Medicine. He is an attending surgeon at Presbyterian Medical Center and Pennsylvania Hospital where he is Clinical Director of Cardiothoracic Surgery. He has a special interest in valvular heart surgery, particularly mitral valve repair. He does minimally invasive heart surgery, including port access and videoscopic surgery. He also has a special interest in high-risk coronary bypass and off-pump bypass.

 
Faculty Appointments
1974 - 1978 Assistant Instructor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1978 - 1979 Instructor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1981 Instructor of Vascular Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1982 - 1983 Instructor of Thoracic Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1984 - 1988 Assistant Professor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1988 - 1990 Clinical Assistant Professor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1990 - 1991 Associate Professor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1991 - 1996 Clinical Associate Professor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1996 Associate Professor of Cardiothoracic Surgery
Allegheny University Hospitals-MCP Division
Philadelphia, Pennsylvania
 
1996 - 1998 Professor of Cardiothoracic Surgery
Allegheny University Hospitals-MCP Division
Philadelphia, Pennsylvania
 
1998 - 2000 Clinical Associate Professor of Surgery
Section of Cardiothoracic Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2000 - present Clinical Professor of Surgery
Section of Cardiothoracic Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
1983 - present Surgical Staff, Presbyterian Medical Center
Philadelphia, Pennsylvania
 
1984 - present Surgical Staff, University of Pennsylvania Medical Center
Philadelphia, Pennsylvania
 
1988 - present Surgical Staff, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
1988 - 1989 Chief of Cardiothoracic Surgery
Pennsylvania Hospital,
Philadelphia, Pennsylvania
 
1998 - present Clinical Director, Cardiothoracic Surgery
Presbyterian Medical Center
Philadelphia, Pennsylvania
 
Education/Training
1965 - 1969 B.S. University of North Carolina
 
1969 - 1973 M.D. Bowman Gray School Medicine
 
Postgraduate Training and Fellowship Appointments
1973 - 1974 Intern, Metropolitan Hospital, New York, New York
 
1974 - 1979 Resident, Department of Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1976 - 1977 Fellow, Harrison Department of Surgical Research University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1977 - 1978 Clinical Fellow, American Cancer Society
 
1978 - 1979 Chief Resident, Department of Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1981 Fellow, Vascular Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1982 - 1983 Fellow, Cardiothoracic Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
Military Service
1979 - 1981 Major, US Army Medical Corps, US Army Hospital
Wuerzberg, West Germany
 
Memberships/Societies
 
National Societies
  • American Association for Thoracic Surgery
  • American College of Cardiology
  • American College of Chest Physicians
  • American College of Surgeons
  • American Heart Association
  • American Medical Association
  • European Association for Cardio-Thoracic Surgery
  • International Society for Minimally Invasive Cardiac Surgery
  • Heart Rhythm Society
  • Society of Thoracic Surgeons
  • The Society for Heart Valve Disease
Local/Regional Societies
  • College of Physicians of Philadelphia
  • Pennsylvania Association of Thoracic Surgery
  • Philadelphia Academy of Surgery
 
Research
 
Research Publications, peer reviewed
  1. Hargrove WC, Mullen JL, Stein TP, Oram-Smith JC, Rosato EF: Mucosal erosions and depressed gastric protein synthesis in the semi-starved rat. Surg. Forum 28:366-369,1977.
  2. Hargrove WC, Mullen JL, Hicks RE, Rosato EF: Cecal necrosis after open heart surgery. Ann Thor Surg. 25(1):71-74, Jan. 1978.
  3. Gertner MH, Hargrove WC, Roberts B: Inferior vena caval obstruction from ruptured abdominal aortic aneurysm. Surgery 83(5):605-610, May 1978.
  4. Mullen JL, Hargrove WC, Dudrick SJ, Fitts WT, Rosato EF: Ten years experience with hyperalimentation and inflammatory bowel disease. Ann Surg 187(5):523-528, May 1978.
  5. Stein TP, Mullen JL, Oram-Smith JC, Rosato EF, Wallace HW, Hargrove WC: Relative rate of tumor, normal gut, liver and fibrinogen protein synthesis in man. Am J Phys 234(6):E648-651, June 1978.
  6. Hargrove WC, Gertner MH, Fitts WT: The Kraske operation for rectal cancer. Surg Gyn Ob 148(6):931-933, June 1979.
  7. Hargrove WC, Harken AH: Palliation of massive hemoptysis from unresectable carcinoma of the lung. Chest 76(2):234-235, Aug. 1979.
  8. Stein TP, Hargrove WC, Miler EE, Wallace HW, Buzby DB, Mullen JL: Effects of nutritional status and 5 fluorouracil on protein synthesis in parenterally alimented rats. JNCL 63(2):379-383, Aug. 1979.
  9. Mullen JL, Buzby GB, Gertner MH, Stein TP, Hargrove WC, Oram-Smith JC, Rosato EF: Protein synthesis dynamics in gastrointestinal malignancies. Surgery 87(3):331-338, Mar. 1980.
  10. Stein TP, Buzby GB, Hargrove WC, Leskiw MJ, Mullen JL: Essential fatty acid defici-ency in patients receiving simultaneous parenteral and oral nutrition. J Parenteral & Ent Nutr 4(4):343-345, July/Aug. 1980.
  11. Stein TP, Buzby GB, Hargrove WC, Leskiw MJ, Mullen JL: Effect of parenteral nutri-tion on protein synthesis and liver fat metabolism in man. J Parenteral & Ent Nutr 239(4):343-345, Oct.1980.
  12. Hargrove WC, Ring EJ, McLean GK, Friedman DB, Berkowitz HD, Roberts B: Recan-alization of totally occluded vein grafts using low-dose streptokinase. Surgery 92(5):890-895, Nov. 1982.
  13. Hargrove WC, Barker CF, Berkowitz HD, Perloff LJ, McLean GK, Friedman DB, Ring EJ, Roberts B: Treatment of acute peripheral arterial and graft thrombosis with low-dose streptokinase. Surgery 92(6):981-993, Dec. 1982.
  14. Hargrove WC, Edmunds LH: Management of infected thoracic aortic prosthetic grafts. Annals Thor Surg 37(1):72-77, Jan. 1984.
  15. Miller JM, Harken AH, Hargrove WC, Josephson ME: Subendocardial resection for sustained ventricular tachycardia early post myocardial infarction. Am J Cardiol 55(8):980-984, Apr. 1, 1985.
  16. Miller JM, Harken AH, Hargrove WC, Josephson ME: Pattern of endocardial resection for sustained ventricular tachycardia. JACC 6(6):1280-1287, Dec. 1985.
  17. Miller JM, Vasallo JA, Hargrove WC, Josephson ME: Intermittent failure of local con-duction during ventricular tachycardia. Circ 72(6):1286-1292, Dec. 1985.
  18. Marchlinski FE, Flores BL, Buxton AE, Hargrove WC, Adonizio VP, Stephenson LW, Harken AH, Doherty JU, Grogan EW, Josephson ME: The automatic implantable cardio-verter defibrillator: Efficiency, complications and device failures. An Int Med 104(4): 481-488, Apr. 1986.
  19. Haas G, Parr G, Trout RG, Hargrove WC: Traumatic coronary artery fistula. J Trauma 26(9):854-857, Sept. 1986.
  20. Hargrove WC, Miller JM, Vassallo JA, Josephson ME: Improve results in the operative management of ventricular tachycardia related to inferior wall myocardial infarction: importance of the annular isthmus. J Thor & Card Surg 92(4):726-734, Oct. 1986.
  21. Miller JM, Vassalo JA, Kussmaul WG, Cassidy DM, Hargrove WC, Josephson ME: Anterior left ventricular aneurysm: Factors associated with the development of sustained ventricular tachycardia. JACC 12(2):375-382, Aug. 1988.
  22. Marchlinski FE, Flores B, Miller JM, Gottlieb CD, Hargrove WC: The relationship of the intraoperative defibrillation threshold to successful postoperative defibrillation with the implantable defibrillator. AJC 62(7):393-398, Sept. 1, 1988.
  23. Markovitz LJ, Frame LH, Josephson ME, Hargrove WC: Cardiac cryolesions: Factors affecting their size and a means of monitoring their formation. Ann Thor Surg 46(5):531-535, Nov. 1988.
  24. Hass GE, Parr GV, Hargrove WC, Trout RG: Coronary artery bypass surgery prior to resection of abdominal aortic aneurysm in patients with unstable coronary artery disease. J of AOA 89(3):307-310, 313, Mar. 1989.
  25. Stephenson LW, Hargrove WC 3rd, Ratcliffe MB, Edmunds LH Jr. Surgery for left ventricular aneurysm: Early survival with and without endocardial resection. Circ. 79(6 Pt 2):I108-111, June 1989.
  26. Hargrove WC, Miller JM: Risk stratification and management of patients with recurrent ventricular tachycardia and other malignant ventricular arrhythmias: Circ 79 (6 Pt 2):I178-181, June 1989.
  27. Hargrove WC, Josephson ME, Marchlinski FE, Miller JM: Surgical decisions in the management of sudden cardiac death and malignant ventricular arrhythmias:
    Subendocardial resection, the automatic internal defibrillator, or both. J Thor & Card Surg 97(6):923-928, June 1989.
  28. Markovitz LJ, Savage EB, Tarcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC, Bogen DK, Edmunds LH: A large animal mode of left ventricular aneurysm. Ann Thor Surg 48(6):838-845, Dec. 1989.
  29. Bavaria JE, Miller JM, Josephson ME, Hargrove WC 3rd. Endocardial resection in the treatment of ventricular tachycardia secondary to cardiac trauma. J Cardiovasc Surg 32(1):50-52, Jan./Feb. 1991.
  30. Ren JF, Aksut S, Lighty GW Jr, Vigilante GJ, Sink JD, Segal BL, Hargrove WC 3rd. Mitral valve repair is superior to valve replacement for the early preservation of cardiac func-tion: Relation of ventricular geometry to function. Am Heart J 131(5):974-981, May 1996.
  31. Hargrove WC 3rd, Addonizio VP, Miller JM. Surgical therapy of ventricular tachyarrhythmias in patients with coronary artery disease. J Cardiovasc Electrophys 7(5):469-480, May 1996.
  32. Szeto, WY, Bavaria, JE, Bowen, FW, Geirsson, A, Cornelius, K, Hargrove, WC 3rd, Pochettino, A. Reoperative Aortic Root Replacement in Patients With Previous Aortic Surgery. Ann Thor Surg 84:1592-99, 2007.
  33. Modi, Hargrove WC 3rd, Rodriguez, Hassan, Szeto, Chitwood. Minimally Invasive Videoscopic Mitral Valve Surgery: A Twelve-Year Two-Center Experience in 1178 Patients. J Thorac Cardiovasc Surg 2009;137:1481-7.
  34. Meyer SR, Szeto WY, Augoustides JG, Morris RJ, Vernick WJ, Paschal D, Fox J, Hargrove WC 3rd. Reoperative mitral valve surgery by the port access minithoracotomy approach is safe and effective. Ann Thorac Surg; 87(5): 1426-30, May 2009.
  35. Suri RM, Schaff HV, Meyer SR, Hargrove WC 3rd. Thoracoscopic versus open mitral Valve Repair: A Propensity Score Analysis of Early Outcomes. Ann Thorac Surg. 2009 Oct;88(4):1185-90.
  36. Vernick WJ, Hargrove WC 3rd, Augoustides JG, Horak J. Takotsubo Cardiomyopathy Associated with Cardiac Arrest Following Cardiac Surgery: New Variants of An Unusual Syndrome. J Card Surg. 2010 Oct; 25:679-683.
Research Publications, Non-Peer Reviewed
  1. Kreiner G, Gottlieb CD, Yeh IT, Furukawa S, Miller JM, Edmunds LH, Bavaria JE, Bernstein RC, Hargrove WC, Tyson GS: Surg For 39:219-221, 1989.
  2. Ren JF, Aksut S, Lighty G, Vigilante G, Rosner H, Hargrove WC, Sink JD, Segal B: Communicating vs noncommunicating acute thoracic aortic dissection: Two case reports and diagnostic value of transesophageal echocardiography and alternative imaging modalities. Am J Noninvas Cardiol 8:238-243, 1994.
  3. Ren JF, Aksut S, Lighty G, Vigilante GJ, Rosner HM, Gioia G, Sink JD, Iskandrian AS, Hargrove WC: Effect of mitral valve repair on cardiac function: Assessment by intraoperative transesophageal echocardiography. J Cardiovas Diag & Proc 12(3):171-180, 1995.
 
Publications
 
Abstracts (last 3 years)
  1. Morris, RJ, Pochettino, A, Hargrove, WC, Vigilante, GJ, Weiss, RL: Transesophageal echocardiographic-guided surgical treatment of right atrial thrombi. Chest 2001. (Presented at American College of Chest Physicians, Philadelphia, PA, November 2001).
  2. Hargrove, WC, Waxman, HL, Fox, JT, Morris, RH: Videoscopic Intracardiac Operations-Experience in 180 Patients. Heart Surgery Forum, 6:S11, 2003. (Presented at the International Society of Minimally Invasive Cardiac Surgery, San Francisco, June 2003).
  3. Szeto, W, Hargrove, WC: Aortic Root Replacement Using Perimount Valve. (Presented At the Pennsylvania Association for Thoracic Surgery 42nd Annual Meeting, Philadelphia, October 2004).
  4. W.Y.Szeto; J.E. Bavaria; F.W. Bowen; A. Geirsson; W.C. Hargrove; A. Pochettino: Reoperative Aortic Root Replacement in Patients With Previous Aortic Surgery. (Presented at the STS 43rd Annual Meeting, San Diego, CA, January, 2007).
Editorials, Reviews, Chapters, including participation in committee reports
  1. Stein TP, Mullen JL, Rosato EF, Wallace HW, Hargrove WC: Effect of parenteral nutrition on human and rat protein synthesis rates. In Stable Isotopes. New York: Academic Press, 1979, 611-618.
  2. Josephson ME, Miller JM, Hargrove WC: Intraoperative mapping of ventricular tachycardia associated with coronary artery disease. In Josephson ME (ed.): Ventricular Tachycardia: Mechanisms & Management. Mt. Kisco, NY: Futura Publishing Co., 1982.
  3. Roberts B, Hargrove WC, McLean GK: Thrombolytic therapy in occluded arteries and bypass grafts. In Bergen JJ, Yao JST (eds): Manuscripts for Symposium on Vascular Surgery. Chicago, 1983.
  4. Berkowitz HD, Hargrove WC, Roberts B: Thrombolytic therapy. In Kipczinski (ed.): Management of the Ischemic Lower Extremity. Chicago: Yearbook Medical Publishers, 1984.
  5. Hargrove WC, Harken AH: Thoracic aorta. Chap. 9 in McCombs P, Horwitz O, Roberts B (eds.): Diseases of Blood Vessels. Philadelphia: Lea & Febiger, 1985, 166-176.
  6. Acker M, Hargrove WC, Stephenson LW: Multiple valve replacement. In: Card Clinics. Philadelphia: WB Saunders, 3:425-430, Aug. 1985.
  7. Buxton AE, Miller JM, Hargrove WC, Marchlinski FE, Doherty JU, Harken AH, Josephson ME: Surgical therapy of ventricular tachycardia. In: Proceedings from the International Symposium on Invasive Cardiovascular Therapy: Recent Advances and Future Developments. Cologne, Germany, May 5-8, 1985.
  8. Hargrove WC, Harken AH: Surgical treatment of cardiac arrhythmias. In Cheng T (ed.): International Practice Cardiology 1986.
  9. Hargrove WC, Miller JM, Josephson ME: Use of the automatic implantable cardioverter defibrillator. Letter to the Editor. N Engl J Med 315(1):63-64, July 3, 1986.
  10. Miller JM, Hargrove WC, Josephson ME: Significance of “nonclinical” ventricular arrhythmias induced following surgery for ventricular tachycardia. In Breitharadt C, Borggrefe M, Zipes DP: Nonpharmacological Therapy of Tachyrhythmias. New York: Futura Publishing Co., 1987, 133.
  11. Berkowitz HD, Hargrove WC, Roberts B: Thrombolysis in vascular disease. Chapter 16B in Wilson, Verth, Robson and Williams (eds.). Vascular Surgery, Principles and Practice. New York: McGraw-Hill, 1987, 241-252.
  12. Hargrove WC: Surgery for ischemic ventricular tachycardia--- Operative techniques and long-term results. [Review] Sem in Thor & Cardiovasc Surg 1(1):83-87, July 1989.
  13. Hargrove WC: Surgery for ventricular tachycardia associated with ischemic heart disease. In: Cardiac Electrophysiology. 1989.
  14. Hargrove WC, Miller JM: Endocardial ablation for ischemic ventricular tachycardia. In: Cardiac Surgery-State of the Art Reviews. London: Hanley & Belfus, Inc., 4:1, 1990.
  15. Josephson ME, Miller JM, Horowitz LN, Harken AH, Hargrove WC: Surgery for recurrent ventricular tachyrhythmias. J of Cardiov Reviews & Reports Oct. 1991.
  16. Edmunds HL, Hargrove WC: Mycotic thoracic aortic aneurysm and infected thoracic aortic grafts: Aneurysm of the thoracic aorta. Chest Surgery Clinics of North America 2(2):397-412, May 1992.
  17. Hargrove WC, Bavaria JE: Surgery for malignant ventricular arrhythmias. Chap. 14 in Josephson ME (ed.) Sudden Cardiac Death. Boston: Blackwell Scientific Publications, 1993, 345-355.
  18. Kegel J, Lighty G, Hargrove WC, Miller JM, Gottlieb CD: Congenital left atrial aneurysm: A case report and review of the literature: Video J of Echocard 3(1):12-24, Jan. 1993.
  19. Mitra RL, Vol Pol P, Miller JM, Hargrove WC, Josephson ME: Results of surgery for ventricular tachycardia. In Akhtar, Myerburg and Ruskin (eds.): Sudden Cardiac Death-Prevalence, Mechanisms and Approaches to Diagnosis and Management. Baltimore: Williams & Wilkins, May 1994.

Dr. Clark Hargrove

 
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