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Holly L. Hedrick, MD, FAAP, FACS
Pediatric Surgery

 
  • Profile Home
  • Appointments
  • Education
  • Memberships
  • Research
  • Publications

Administrative Office:
The Childrens Hospital of Philadelphia
Department of Pediatric General Surgery
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Administrative Assistant: Joan Leahy
Administrative Telephone: 215-590-2733
Administrative Fax: 215-386-4036

Clinical Offices:
The Childrens Hospital of Philadelphia
Department of Pediatric General Surgery
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-590-2733
Clinical Fax: 215-386-4036
Patient Appointments: 215-590-2733

hedrick@email.chop.edu

Link to Children's Hospital of Philadelphia

 
Special Interests
  • Clinical applications of fetal diagnosis and therapy
  • Neonatal surgery
  • Laparoscopy and thoracoscopy
  • Oncology
  • ECMO
  • Thoracic surgery

 

 
Faculty Appointments
1991 - 1994 Clinical Fellow in Surgery, Harvard Medical School
Boston, Massachusetts
 
1994 - 1996 Research Fellow in Surgery, Harvard Medical School Boston, Massachusetts
 
1996 - 1998 Clinical Fellow in Surgery, Harvard Medical School
Boston, Massachusetts
 
1998 - 2000 Instructor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2000 - 2006 Assistant Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2006 - 2012 Assistant Professor of Surgery at CHOP
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
   
2012 - present  Associate Professor of Surgery at CHOP
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
1999 - present Attending Surgeon
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
1999 - present Provisional/Consulting Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2000 - present Professional Staff Surgeon
Pennsylvania Hospital
Philadelphia, Pennsylvania
 
2000 - present Investigator, Children's Institute for Surgical Science
Abramson Pediatric Research Center
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
Education/Training
1987 B.S. Indiana University, Bloomington, Indiana
(Biology, With Highest Distinction)
 
1991

M.D. Duke University School of Medicine
Durham, North Carolina

 
Postgraduate Training and Fellowship Appointments
1986 Research-only Fellowship
Indiana University School of Medicine
Biomedical Research Program,
Krannert Institute of Cardiology
Bloomington, Indiana
 
1989 - 1990 Research-only Fellowship
Duke University School of Medicine
Surgical Oncology Research Facility
Durham, North Carolina
 
1991 - 1992 Internship in General Surgery
Brigham & Women’s Hospital / Harvard Medical School
Boston, Massachusetts
 
1992 - 1994 Residency in General Surgery
Brigham & Women’s Hospital / Harvard Medical School
Boston, Massachusetts
 
1994 - 1996

Research-only Fellowship, Department of Pediatric Surgery
Pediatric Surgical Research Laboratories
Massachusetts General Hospital
Boston, Massachusetts

 
1996 - 1997 Residency in General Surgery
Brigham & Women’s Hospital / Harvard Medical School
Boston, Massachusetts
 
1997 - 1998 Chief Resident in General Surgery
Brigham & Women’s Hospital / Harvard Medical School
Boston, Massachusetts
 
1998 - 1999 Assistant Chief Resident and Fellow in Pediatric Surgery
The Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
Memberships/Societies
 
Professional and Scientific Societies
1987 - present American Medical Association
 
1992 - present American College of Surgeons
 
1994 - present American Association for the Advancement of Science
 
1999 - present International Pediatric Endosurgical Group
 
2003 - present American Pediatric Surgical Association (APSA)
 
Regional & Local Societies
1987 - 1991 North Carolina Medical Society
 
1989 - 1991 Engel Society, Duke University
   
1989 - 1991 North Carolina Student Rural Health Coalition
   
1991 - present  Massachusetts Medical Society
   
2000 - present Pennsylvania Medical Society
   
2000 - present Philadelphia Perinatal Society
   
2003 Honorary Member, Kansas City Surgical Society
   
Scientific Committees
2004 - 2006  Family Issues Task Force, APSA
   
2004 - 2007  Outcomes Committee, APSA
   
2005 - 2008 Fetal Therapy Committee, APSA
 
Research
 
 
 
 
 
 
 
 
 
 
Publications
Research Publications, Peer-Reviewed
  1. Schnitzer JJ, Hedrick HL, Pacheco BA, Losty PD, Ryan DP, Doody DP, Donahoe PK.  Prenatal glucocorticoid therapy reverses pulmonary immaturity in congenital diaphragmatic hernia in fetal sheep.  Annals of Surgery 224(4):430-439, Oct. 1996.
  2. Schnitzer JJ, Thompson JE, Hedrick HL, Kaban JM, Wilson JM.  High frequency intratracheal pulmonary ventilation: improved gas exchange at lower airway pressures.  Journal of Pediatric Surgery 32(2):203-206, Feb. 1997.
  3. Hedrick HL, Kaban JM, Pacheco BA, Losty PD, Doody DP, Ryan DP, Manganaro TF, Donahoe  PK, Schnitzer JJ.  Prenatal glucocorticoids improve pulmonary morphometrics in fetal sheep with congenital diaphragmatic hernia.  Journal of Pediatric Surgery 32(2):217-222, Feb. 1997.
  4. Schnitzer JJ, Thompson JE, Hedrick HL.  A new ventilator improves CO2 removal in newborn lambs with congenital diaphragmatic hernia.  Critical Care Medicine 27(1):109-112, Jan. 1999.
  5. Nance ML, Adamson WT, Hedrick HL.  Appendicitis in the young child: A continuing diagnostic challenge. Pediatric Emergency Care 16(3):160-162, June 2000.
  6. McElhinney DB, Hedrick HL, Bush DM, Pereira GR, Stafford PW, Gaynor JW, Spray TL, Wernovsky G.  Necrotizing enterocolitis in neonates with congenital heart disease: Risk factors and outcomes.  Pediatrics 106(5):1080-1087, Nov. 2000.
  7. Hedrick HL, Nelson RM.  Handling ethical conflicts in the clinical setting.  Seminars in Pediatric Surgery 10(4):192-197, Nov. 2001.
  8. Crombleholme TM, Coleman B, Hedrick H, Liechty K, Howell L, Flake AW, Johnson M, Adzick NS.  Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung.  Journal of Pediatric Surgery 37(3):331-338, Mar. 2002.
  9. Davey MG, Hedrick HL, Mendoza JM, Kanai M, Adzick NS, Flake AW.  Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion.  Pediatric Pulmonology 34(4):278-286, Oct. 2002.
  10. Davey MG, Hedrick HL, Bouchard S, Mendoza JM, Schwarz U, Adzick NS, Flake AW.  Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function.  Journal of Applied Physiology 94(3):1054-62, Mar. 2003.
  11. Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW, Doolin EJ.  Computer-assisted stereology: Point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning 25(1):37-44, Jan./Feb. 2003.
  12. Lim FY, Crombleholme TM, Hedrick HL, Flake AW, Johnson MP, Howell LJ, Adzick NS. Congenital high airway obstruction syndrome: Natural history and management.  Journal of Pediatric Surgery 38(6):940-945, June 2003.
  13. Hedrick HL. Ex utero intrapartum therapy.  Seminars in Pediatric Surgery 12(3):190-195, Aug. 2003.
  14. Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ, Hedrick HL, Wilson RD, Adzick NS.  Fetal myelomeningocele repair: Short-term clinical outcomes.  American Journal of Obstetrics & Gynecology 189(2):482-487, Aug. 2003.
  15. Wilson RD, Johnson MP, Crombleholme TM, Flake AW, Hedrick HL, King M, Howell LJ, Adzick NS.  Chorioamniotic membrane separation following open fetal surgery: Pregnancy outcome.  Fetal Diagnosis & Therapy 18(5):314-320, Sept./Oct. 2003.
  16. Hedrick HL, Crombleholme TM, Flake AW, Nance ML, von Allmen D, Howell LJ, Johnson MP, Wilson RD, Adzick NS.  Right congenital diaphragmatic hernia: Prenatal assessment and outcome. Journal of Pediatric Surgery 39(3):319-323, Mar. 2004.
  17. Wilson RD, Baxter JK, Johnson MP, King M, Kasperski S, Crombleholme TM, Flake AW, Hedrick HL, Howell LJ, Adzick NS.  Thoracoamniotic shunts: Fetal treatment of pleural effusions and congenital cystic adenomatoid malformations.  Fetal Diagnosis & Therapy 19(5):413-420, Sept./Oct. 2004.
  18. Wilson RD, Johnson MP, Flake AW, Crombleholme TM, Hedrick HL, Wilson J, Adzick NS.  Reproductive outcomes after pregnancy complicated by maternal-fetal surgery.  American Journal of Obstetrics & Gynecology 191(4):1430-1436, Oct. 2004.
  19. Danzer E, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Sutton LN, Adzick NS.  Fetal head biometry following in-utero repair of myelomeningocele.  Ultrasound in Obstetrics & Gynecology 24(6):606-611, Nov. 2004.
  20. Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, Adzick NS, Flake AW, Hedrick HL. Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia.  Pediatric Pulmonology 39(4):359-367, Apr. 2005.
  21. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS.  The ex utero intrapartum therapy procedure for high-risk fetal lung lesions. Journal of Pediatric Surgery 40(6):1038-1044, June 2005.
  22. Keswani SG, Crombleholme TM, Tychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery. Fetal Diagnosis & Therapy 20(4):316-320, July/Aug. 2005.
  23. Biard JM, Johnson MP, Carr MC, Wilson RD, Hedrick HL, Pavlock C, Adzick NS.  Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. Obstetrics & Gynecology 106(3):503-508, Sept. 2005.
  24. Danzer E, Robinson LE, Davey MG, Schwarz U, Volpe MA, Adzick NS, Flake AW, Hedrick HL. Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression. Journal of Pediatric Surgery 41(4):774-780, Apr. 2006.
  25. Kreiger PA, Ruchelli ED, Mahboubi S, Hedrick H, Adzick NS, Russo PA. Fetal pulmonary malformations: defining histopathology.  American Journal of Surgical Pathology 30(5):643-649, May 2006.
  26. Danzer E, Hubbard AM, Hedrick HL, Johnson MP, Wilson RD, Howell LJ, Flake AW, Adzick NS. Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MR imaging.  American Journal of Roentgenology187(4):W350-6, Oct. 2006.
  27. Davey MG, Danzer E, Schwarz U, Robinson L, Shegu S, Adzick NS, Flake AW, Hedrick HL. Prenatal glucocorticoids improve lung morphology and partially restore surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion. Pediatric Pulmonology 41(12):1188-1196, Dec. 2006.
  28. Ferdman B, States L, Gaynor JW, Hedrick HL, Rychik J.  Abnormalities of intestinal rotation in patients with congenital heart disease and the heterotaxy syndrome.  Congenital Heart Disease 2(1):12-18, Jan. 2007.
  29. Wilson RD, Johnson MP, Bebbington M, Flake AW, Hedrick HL, Sutton LN, Adzick NS. Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?  Fetal Diagnosis & Therapy 22(5):348-351, 2007.
  30. Netta DA, Wilson RD, Visintainer P, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Gastroschisis: Growth patterns and a proposed prenatal surveillance protocol. Fetal Diagnosis & Therapy 22(5):352-357, 2007.
  31. Peranteau WH, Wilson RD, Liechty KW, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survival.  Fetal Diagnosis & Therapy 22(5):365-71, 2007.
  32. Davey M, Shegu S, Danzer E, Ruchelli E, Adzick S, Flake A, Hedrick HL. Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy. American Journal of Obstetrics & Gynecology 197(4):381.e1-7, Oct. 2007.
  33. Crombleholme TM, Shera D, Lee H, Johnson M, D'Alton M, Porter F, Chyu J, Silver R, Abuhamad A, Saade G, Shields L, Kauffman D, Stone J, Albanese CT, Bahado-Singh R, Ball RH, Bilaniuk L, Coleman B, Farmer D, Feldstein V, Harrison MR, Hedrick H, Livingston J, Lorenz RP, Miller DA, Norton ME, Polzin WJ, Robinson JN, Rychik J, Sandberg PL, Seri I, Simon E, Simpson LL, Yedigarova L, Wilson RD, Young B. A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome.  American Journal of Obstetrics & Gynecology 197(4):396.e1-9, Oct. 2007.
  34. Hedrick HL, Danzer E, Merchant A, Bebbington MW, Zhao H, Flake AW, Johnson MP, Liechty KW, Howell LJ, Wilson RD, Adzick NS.  Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia.  American Journal of Obstetrics & Gynecology 197(4):422.e1-4, Oct. 2007.
  35. Husler MR, Wilson RD, Rychik J, Bebbington MW, Johnson MP, Mann SE, Hedrick HL, Adzick S. Prenatally diagnosed fetal lung lesions with associated conotruncal heart defects: Is there a genetic association?  Prenatal Diagnosis 27(12):1123-1128, Dec. 2007.
  36. Tiblad E, Wilson RD, Carr M, Flake AW, Hedrick H, Johnson MP, Bebbington MW, Mann S, Adzick NS.  OEIS sequence: A rare congenital anomaly with prenatal evaluation and postnatal outcome in six cases.  Prenatal Diagnosis 28(2):141-147, Feb. 2008.
  37. Tsai AY, Liechty KW, Hedrick HL, Bebbington M, Wilson RD, Johnson MP, Howell LJ, Flake AW, Adzick NS.  Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions.  Journal of Pediatric Surgery 43(3):513-517, Mar. 2008.
  38. Biard JM, Schwarz U, Davey MG, Danzer E, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs.  Journal of             Pediatric Surgery 43(4):620-626, Apr. 2008.
  39. Badillo AT, Hedrick HL, Wilson RD, Danzer E, Bebbington MW, Johnson MP, Liechty KW, Flake AW, Adzick NS.  Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. Journal of Pediatric Surgery  43(4):647-653, Apr. 2008.
  40. Danzer E, Davey MG, Kreiger P, Ruchelli ED, Johnson MP, Adzick NS, Flake AW, Hedrick HL. Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometrics study of lung parenchyma and muscularization of pulmonary arterioles.  Journal of Pediatric Surgery 43(10):1767-1775, Oct. 2008.
  41. Wilson RD, Hedrick H, Flake AW, Johnson MP, Bebbington MW, Mann S, Rychik J, Liechty K, Adzick NS. Sacrococcygeal teratomas: Prenatal surveillance, growth and pregnancy outcome. Fetal Diagnosis & Therapy 25(1):15-20, 2009, Epub Dec. 20, 2008.
  42. Nance ML, Nadkarni VM, Hedrick HL, Cullen JA, Wiebe DJ.  Effect of preextracorporeal membrane oxygenation ventilation days and age on extracorporeal membrane oxygenation survival in critically ill children. Journal of Pediatric Surgery 44(8):1606-1610, Aug. 2009.
  43. Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Adzick NS, Hedrick HL. Prospective interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: Short-term neurodevelopmental outcome. Journal of Pediatric Surgery 45(4):718-723, Apr. 2010.
  44. Roybal JL, Liechty KW, Hedrick HL, Bebbington MW, Johnson MP, Coleman BG, Adzick NS, Flake AW.  Predicting the severity of congenital high airway obstruction syndrome.  Journal of Pediatric Surgery 45(8):1633-1639, Aug. 2010.
  45. Wilson RD, Lemerand K, Johnson MP, Flake AW, Bebbington M, Hedrick HL, Adzick NS. Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007). American Journal of Obstetrics & Gynecology 203(3):209.e1-6, Sept. 2010.
  46. Danzer E, Gerdes M, Bernbaum J, D’Agostino J,  Bebbington MW, Siegle J, Hoffman C, Rintoul NE, Hedrick HL. Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program. Journal of Pediatric Surgery 45(9):1759-1766, Sept. 2010.
  47. Santore MT, Behar BJ, Blinman TA, Doolin EJ, Hedrick HL, Mattei P, Nance ML, Adzick NS, Flake AW.  Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cyst.  Journal Pediatric Surgery 46(1):209-213, Jan. 2011.
  48. Davey MG, Zoltick PW, Todorow CA, Limberis MP, Ruchelli ED, Hedrick HL, Flake AW. Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung.  Gene Therapy June 9, 2011. (Epub ahead of print)
  49. Roybal JL, Moldenhauer JS, Khalek N, Bebbington MW, Johnson MP, Hedrick HL, Adzick NS, Flake AW.  Early delivery as an alternative management strategy for selected high-risk fetal sacrococcygeal teratomas.  Journal of Pediatric Surgery 46(7):1325-1332, July 2011.
  50. Cahill AM, Nijs E, Ballah D, Rabinowitz D, Thompson L, Rintoul N, Hedrick H, Jacobs I, Low D.  Percutaneous sclerotherapy in neonatal and infant head and neck lymphatic malformations: a single center experience.  Journal of Pediatric Surgery 46(11):2083-95, Nov. 2011.
  51. Tibbetts MD, Wise R, Forbes B, Hedrick HL, Levin AV.  Hypertensive retinopathy in a child caused by pheohromocytoma: Identification after failed school vision screening.  Journal of the American Association for Pediatric Ophthalmology and Strabismus. 16 (1):97-9. Feb. 2012
  52. Danzer E, Victoria T, Bebbington MW, Flake AW, Adzick NS, Hedrick HL.  Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele – preliminary findings.  Fetal Diagnosis & Therapy 31(4):248-53 Apr 2012
  53. Danzer E, Zarnow D, Siegle J, D’Agostino J, Gerdes M, Bebbington MW, Flake AW, Adzick NS, Hedrick HL.  Abnormal brain development and maturation on MR imaging in survivors of severe congenital diaphragmatic hernia.  Journal of Pediatric Surgery 47(3):453-61. Mar. 2012
  54. Danzer E, Siegle J, D’Agostino J, Gerdes M, Hoffman C, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.  Early neurodevelopmental outcome of infants with high-risk fetal lung lesions.  Fetal Diagnosis & Therapy 31(4):210-5. Apr. 2012
Reviews in Peer Reviewed Research Publications
  1. MacKenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LN, Adzick NS.  The natural history of prenatally diagnosed conjoined twins. [Review] Journal of Pediatric Surgery 37(3):303-309, Mar. 2002.
  2. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS.  History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience. [Review] Fetal Diagnosis & Therapy 18(2):65-82, Mar./Apr. 2003.
  3. Biard JM, Wilson RD, Johnson MP, Hedrick HL, Schwarz U, Flake AW, Crombleholme TM, Adzick NS.  Prenatally diagnosed giant omphaloceles: Short- and long-term outcomes. [Review] Prenatal Diagnosis 24(6):434-439, June 2004.
  4. Rychik J, Tian Z, Cohen MS, Ewing SG, Cohen D, Howell LJ, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, Adzick NS.  Acute cardiovascular effects of fetal surgery in the human. [Review] Circulation 110(12):1549-1556, Sept. 21, 2004.
  5. Wilson RD, Hedrick HL, Liechty KW. Flake AW. Johnson MP. Bebbington M. Adzick NS. Cystic adenomatoid malformation of the lung: Review of genetics, prenatal diagnosis, and in utero treatment. [Review] American Journal of Medical Genetics. Part A 140(2):151-155, Jan. 15, 2006.
  6. Ilagan JG, Wilson RD, Bebbington M, Johnson MP, Hedrick HL, Liechty KW, Adzick NS. Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestations. [Review] Fetal Diagnosis & Therapy 23(2):153-158, 2008.
  7. Hedrick HL. Management of prenatally diagnosed congenital diaphragmatic hernia. [Review] Seminars in Fetal & Neonatal Medicine 15(1):21-27, Feb. 2010.  Epub Nov. 2, 2009.
  8. Danzer E, Hedrick HL.  Neurodevelopmental and neurofunctional outcomes in children with congenital diaphragmatic hernia. [Review]  Early Human Development 87(9):625-632, Sept. 2011 (Epub ahead of print June 2, 2011).
Abstracts (last three years)
  1. Dinan D, Victoria T, Danzer E, Hedrick HL, Bebbington MW, Anupindi S, Adzick NS. Which factors are predictive of survival in left congenital diaphragmatic hernia? A multivariate analysis.  Pediatric Radiology 39 (Suppl 2):S253, 2009.
  2. Behar B, Minneci PC, Kilbaugh TJ, Hedrick HL, Deans KJ. Variables associated with increased mortality on pediatric patients requiring Extracorporeal Life Support for a primary diagnosis of pneumonia. CNMC Symposium: ECMO & the Advanced Therapies for Respiratory Failure, Feb. 2010. A55.
  3. Kilbaugh TJ, Topjian AA, Chandler HK, Hedrick HL, McCloskey JM, Deans KJ. Influenza A (H1N1) and MRSA acute respiratory distress syndrome and cardiogenic shock supported with Extracorporeal Membrane Oxygenation and Plasmapheresis. CNMC Symposium: ECMO & the Advanced Therapies for Respiratory Failure, Feb. 2010. A40.
  4. Danzer E, Zarnow D, Siegle J, D’Agostino J, Gerdes M, Bebbington MW, Flake AW, Adzick NS, Hedrick HL. Abnormal brain development and maturation in infants with congenital diaphragmatic hernia: Semiquantitative assessment using MR imaging. 31st Annual Society of Maternal-Fetal Medicine Meeting, Chicago IL, Feb. 7-12, 2011.
  5. Healy F, Victoria T, Bebbington MW, Hedrick HL, Panitch HB.  Lung volume measure-ments by magnetic resonance imaging in fetuses with congenital diaphragmatic  hernia as a predictor of postnatal lung function.  Poster presentation at the American Thoracic Society Meeting, Denver, CO, 2011.
  6. Victoria T, Danzer E, Bebbington M, Flake A, Johnson M, Adzick NS, Hedrick H.  Fetal MR and clinical factors predictive of survival in left congenital diaphragmatic hernia.  Poster presentation at the International Pediatric Radiology Congress, London, UK, 2011.
  7. Danzer E, Gerdes M, D’Agostino J, Hoffman C, Bernbaum MW, Bebbington MW, Siegle J, Rintoul NE, Hedrick HL.  Longitudinal neurodevelopmental (ND) outcome in congenital diaphragmatic hernia (CDH) survivors during the first 3 years of life.  Oral presentation at the Eastern SPR Annual Meeting, Philadelphia, PA, Mar. 25-27, 2011.
  8. Danzer E, Gerdes M, D’Agostino J, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Rintoul NE, Hedrick HL.  Longitudinal neurodevelopmental (ND) outcome in congenital diaphragmatic hernia (CDH) survivors during the first 3 years of life.  Oral presentation at the PAS/ASPR Joint Meeting, Denver, CO, Apr. 30-May 3, 2011.
  9. Danzer E, Victoria T, Bebbington MW, Siegle J, Rintoul NE, Johnson MP, Flake AW, Adzick NS, Hedrick HL.  Fetal MRI-calculated total lung volumes in the prediction of short-term morbidity in giant omphalocele.  Oral presentation at the 30th Annual Meeting of the International Fetal Medicine and Surgery Society, Sedona, AZ, May 13-18, 2011.
  10. Danzer E, Siegle J, D’Agostino J, Gerdes M, Hoffman C, Bernbaum J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.  Early neurodevelopmental outcome of infants with high-risk fetal lung lesions.  Oral presentation at the 30th Annual Meeting of the International Fetal Medicine and Surgery Society, Sedona, AZ, May 13-18, 2011.
Editorials, Chapters, Case Reports & Participation in Committee Reports
  1. Hedrick HL, Schnitzer JJ.  Malformations of the intestine.  In Burg FD, Inglefinger JR, Wald ER, Polin RA (eds.).  Gellis & Kagan’s Current Pediatric Therapy, 16th Edition.  Philadelphia: WB Saunders Co., 1999, 621-624.
  2. Schnitzer JJ, Hedrick HL.  Malformations of the intestine.  In Burg FD, Inglefinger JR, Wald ER, Polin RA (eds.).  Gellis & Kagan’s Current Pediatric Therapy, 16th Edition.  Philadelphia: WB Saunders Co., 1999, 826-829.
  3. Hedrick HL, Stafford PW.  Soft tissue injuries.  In Glick PL, Pearl RH, Irish MS, Caty MG (eds.).  Pediatric Surgery Secrets.  Philadelphia: Hanley & Belfus, 2001, 238-241.
  4. Hedrick HL.  Evaluation and management of congenital diaphragmatic hernia.  Pediatric Case Reviews 1(1):24-28, Oct. 2001.
  5. Hedrick HL, Crombleholme TM. Current status of fetal surgery.  Contemporary OB/GYN 46(12):42-70, Dec. 2001.
  6. Keswani SG, Johnson MP, Adzick NS, Hori S, Howell LJ, Wilson RD, Hedrick H, Flake AW, Crombleholme TM.  In utero limb salvage: Fetoscopic release of amniotic bands for threatened limb amputation. [Case Report] Journal of Pediatric Surgery 38(6):848-851, June 2003.
  7. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. Sacrococcygeal teratoma: Prenatal assessment, fetal intervention, and outcome. [Case Report] Journal of Pediatric Surgery 39(3):430-438, Mar. 2004.
  8. Merchant AM, Hedrick HL, Johnson MP, Wilson RD, Crombleholme TM, Howell LJ, Adzick NS, Flake AW.  Management of fetal mediastinal teratoma. [Case Report] Journal of Pediatric Surgery 40(1):228-231, Jan. 2005.
  9. Keswani SG, Crombleholme TM, Pawel BR, Johnson MP, Flake AW, Hedrick HL, Howell LJ, Wilson RD, Davis GH, Adzick NS.  Prenatal diagnosis and management of mainstem bronchial atresia. [Case Report] Fetal Diagnosis & Therapy 20(1):74-78, Jan./Feb. 2005.
  10. DeMatos V, Russo P, Hedrick H, Piccoli D, Mamula P. A 2 year old girl with persistent ascites. [Case Report] Medscape Aug. 2005.
  11. Jackson MB, Guttenberg M, Hedrick H, Moshang T. Multiple endocrine neoplasia type 2A in a kindred with C634Y mutation. [Case Report] Pediatrics 116(3):e468-71, Sept. 2005.
  12. Liechty KW, Hedrick HL, Hubbard AM, Johnson MP, Wilson RD, Ruchelli ED, Howell LJ, Crombleholme TM, Flake AW, Adzick NS. Severe pulmonary hypoplasia associated with giant cervical teratomas. [Case Report] Journal of Pediatric Surgery 41(1):230-233, Jan. 2006.
  13. Merchant AM, Peranteau W, Wilson RD, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation. [Case Report] Fetal Diagnosis & Therapy 22(6):435-439, 2007.
  14. Hedrick HL, Adzick NS. Congenital diaphragmatic hernia in the neonate. In Rose BD (ed.): UpToDate.  Waltham, MA, 2007.
  15. Hedrick HL, Adzick NS. Congenital diaphragmatic prenatal diagnosis. In Rose BD (ed.): UpToDate.  Waltham, MA, 2007.
  16. Flake AW, Hedrick HL, Congenital diaphragmatic hernia. Chap. 33 in Rodeck C, Whittle E (eds.): Fetal Medicine: Basic Science and Clinical Practice, 2nd Edition.  Philadelphia: Elsevier, 2009, 437-446.
Alternative Media
  1. Hedrick H.  Breathing easier: What families and physicians should know about fetal lung anomalies. Published online by The Center for Fetal Diagnosis and Treatment, The Children’s Hospital of Philadelphia, 2009. http://www.chop.edu/consumer/jsp/division/generic.jsp?id=81164.
  2. Hedrick H.  Everything in its place: Managing the complexities of congenital diaphragmatic hernia. Published on-line by The Center for Fetal Diagnosis and Treatment, The Children’s Hospital of Philadelphia, 2009.  http://www.chop.edu/consumer/jsp/division/generic.jsp?id=81164.
  3. Hedrick H.  Fetal innovations.  Published on-line by The Center for Fetal Diagnosis and Treatment, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2011. http://www.chop.edu/consumer/jsp/division/generic.jsp?id=81164
Contributions to Peer-Reviewed Clinical Research Publications, Participation Cited but not by Authorship
  1. Adzick NS, Thom EA, Spong CY, Briock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D’Alton ME, Farmer DL; MOMS Investigators.  A randomized trial of prenatal versus postnatal repair of myelomeningocele.  New England Journal of Medicine 164(11):993-1004, Mar 17, 2011.  Epub Feb 9, 2011.  (Member of MOMS investigators.)
Research Publications, Non-Peer-Reviewed
  1. Hedrick HL, Pacheco BA, Losty PD, Donahoe PK, Schnitzer JJ.  Dexamethasone increases expression of surfactant associated protein mRNA in rats with nitrofen-induced congential diaphragmatic hernia.  Surgical Forum 66:654-657, 1995.
  2. Hedrick HL, Kaufman OE, Teixeira JM, Donahoe PK, Schnitzer JJ.  Analysis of gene expression in scarless fetal vs. postnatal skin.  Surgical Forum 67:670-673, 1996.

Dr. Holly Hedrick

 
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