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Giorgos C. Karakousis, M.D., F.A.C.S.
Endocrine and Oncologic Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
Department of Surgery
3400 Spruce Street, 4 Silverstein
Philadelphia, PA 19104
Administrative Assistant: Dana Cardona
Administrative Telephone: 215-614-0857
Administrative Fax: 215-662-7476
Patient Appointments:
215-615-5858

Clinical Office:
Perelman Center for Advanced Medicine
Cancer Center
West Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinic Appointments: 215-615-5858
New Patient Coordinator: 215-615-0741
Clinic Fax: 215-615-5881

Contact Information (internal use only)

giorgos.karakousis@uphs.upenn.edu

 

Dr. Giorgos Karakousis is a fellowship trained surgical oncologist. He earned his undergraduate degree from Yale University and his medical degree from the University of Pennsylvania School of Medicine. He completed his general surgery residency training and a research fellowship at the Hospital of the University of Pennsylvania and went on to complete a fellowship in surgical oncology at Memorial Sloan-Kettering Cancer Center. His clinical interests include melanoma, sarcoma and GI malignancies.

 
Faculty Appointments
2010 - present Assistant Professor of Surgery at HUP
Perelman School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2005 - 2006

Resident Coordinator for Medical Students
Department of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania

 
2005 - 2006 Class Representative to the Resident Executive Council, Department of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2008 - 2010 Surgical Oncology Fellow Representative to GME Committee
Memorial Sloan-Kettering Cancer Center
New York, New York
 
2010 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Education/Training
1992 - 1996 B.S., M.S. Yale University
New Haven, Connecticut
 
1997 - 2001 M.D. University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Postgraduate Training and Fellowship Appointments
2001 - 2002 Internship in General Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2002 - 2008 Residency in General Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2004 - 2006 Post-Doctoral Research Fellow
Harrison Department of Surgical Research
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2008 - 2010 Fellowship in Surgical Oncology
Department of Surgery
Memorial Sloan-Kettering Cancer Center
New York, New York
 
Memberships/Societies
 
National/International Societies
2004 - present American College of Surgeons
 
2005 - present Association for Academic Surgery
 
2008 - present American Society of Clinical Oncology
 
2009 - present Society of Surgical Oncology
 
Research
 
Research Publications, Peer Reviewed
  1. Karakousis G, Ye N, Li Z, Chiu S, Reddy G, Radding C. The beta protein of phage lambda binds preferentially to an intermediate in DNA renaturation. Journal of Molecular Biology 276(4): 721-731, Mar. 6, 1998.
  2. Li Z, Karakousis G, Chiu S, Reddy G, Radding C. The beta protein of phage lambda promotes strand exchange. Journal of Molecular Biology 276(4):733-744, Mar. 6, 1998.
  3. Szeto W, Kreisel D, Karakousis G, Pochettino A, Sterman D, Kotloff R, Aracasoy S, Zisman D, Blumenthal N, Gallop R, Kaiser L, Bavaria J, Rosengard B. Cardiopulmonary bypass for bilateral sequential lung transplantation in patients with chronic obstructive pulmonary disease without adverse effect on lung function or clinical outcome. Journal of Thoracic & Cardiovascular Surgery 124(2):241-249, Aug. 2002.
  4. Hendren S, Prabakaran I, Buerk D, Karakousis G, Feldman M, Spitz F, Menon C, Fraker D. Interferon-beta gene therapy improves survival in an immunocompetent mouse model of carcinomatosis. Surgery 135(4):427-436, Apr. 2004.
  5. Kesmodel S, Karakousis G, Botbyl J, Canter R, Lewis R, Wahl P, Alavi A, Elder D, Ming M, Guerry D, Gimotty P, Fraker D, Czerniecki B, Spitz F. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Annals of Surgical Oncology 12(6):449-458, June 2005.
  6. Karakousis G, Gimotty P, Botbyl J, Kesmodel S, Elder D, Ming M, Guerry D, Fraker D, Czerniecki B, Spitz F. Predictors of regional nodal disease in patients with thin melanomas. Annals of Surgical Oncology 13(4): 533-541, Apr. 2006.
  7. Karakousis G, Gimotty P, Elder D, Ming M, Guerry D, Fraker D, Czerniecki B, Spitz F. Regional nodal disease is strongest predictor of survival in patients with thin vertical growth phase melanomas: A case for SLN staging biopsy in these patients. Annals of Surgical Oncology 14(5):1596-1603, May 2007.
  8. Karakousis G, Han D, Rapaport Kelz R, Neemani D, Karamacharya J, Roses R, Fraker D. Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT). Surgery 142(6):845-850, Dec. 2007.
  9. Xu X, Gimotty PA, Guerry D, Karakousis G, Van Belle P, Liang H, Montone K, Pasha T, Ming ME, Acs G, Feldman M, Barth S, Hammond R, Elenitsas R, Zhang PJ, Elder DE. Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Human Pathology 39(6): 901-909, June 2008.
  10. Huang JH, Lee FS, Pasha TL, Sammel MD, Karakousis G, Xu G, Fraker D, Zhang PJ. Analysis of HIF-1alpha and its regulator, PHD2, in retroperitoneal sarcomas: Clinico-patho-logic implications. Cancer Biology & Therapy 9(4):303-311, Feb. 2010 (epub ahead of print).
Reviews in Peer Reviewed Research Publications
  1. Kingham P, Karakousis G, Ariyan C. Randomized clinical trials in melanoma. [Review] Surgical Oncology Clinics of North America 19(1):13-31, Jan. 2010.
 
Publications
  1. Cintolo JA, Gimotty P, Blair A, Guerry D, Elder DE, Hammond R, Elenitsas R, Xu X, Fraker D, Schuchter LM, Czerniecki BJ, Karakousis GLocal Immune Response Predicts Survival in Patients with Thick (T4) Melanomas.  Ann Surg Oncol. 2013 Jul 10. [Epub ahead of print]
  2. Bartlett EK, Meise C, Bansal N, Fischer JP, Low DW, Czerniecki BJ, Roses RE, Fraker DL, Kelz RR, Karakousis GC. Sartorius transposition during inguinal lymphadenectomy for melanoma. J Surg Res. 2013 May 8. [Epub ahead of print]
  3. Bartlett EK, Roses RE, Gupta M, Shah PK, Shah KK, Zaheer S, Wachtel H, Kelz RR, Karakousis GC, Fraker DL.  Surgery for metastatic neuroendocrine tumors with occult primaries. J Surg Res. 2013 Apr 25. [Epub ahead of print]
  4. Yang RL, Newman AS, Lin IC, Reinke CE, Karakousis GC, Czerniecki BJ, Wu LC, Kelz RR. Trends in immediate breast reconstruction across insurance groups after enactment of breast cancer legislation.Cancer. 2013 Apr 12. [Epub ahead of print]
  5. Abraham RM, Karakousis G, Acs G, Ziober AF, Cerroni L, Mihm MC Jr, Elder DE, Xu X. Lymphatic Invasion Predicts Aggressive Behavior in Melanocytic Tumors of Uncertain Malignant Potential (MELTUMP).  Am J Surg Pathol. 2013 May; 37 (5):669-75.
  6. Abel EV, Basile KJ, Kugel CH 3rd, Witkiewicz AK, Le K, Amaravadi RK, Karakousis GC, Xu X, Xu W, Schuchter LM, Lee JB, Ertel A, Fortina P, Aplin AE. Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.  J Clin Invest. 2013 Apr 1. doi:pii: 65780. 10.1172/JCI65780. [Epub ahead of print]
  7. Karakousis GC, Pandit-Taskar N, Hsu M, Panageas K, Atherton S, Ariyan C, Brady MS.  Prognostic significance of drainage to pelvic nodes at sentinel lymph node mapping in patients with extremity melanoma. Melanoma Res. 2013 Feb;23(1):40-6.
  8. Yang RL, Newman AS, Reinke CE, Lin IC, Karakousis GC, Czerniecki BJ, Wu LC, Kelz RR. Racial Disparities in Immediate Breast Reconstruction After Mastectomy: Impact of State and Federal Health Policy Changes. Annals of Surgical Oncology (epub ahead of print Oct 3 2012).
  9. Reinke CE, Karakousis GC, Hadler RA, Drebin JA, Fraker DL, Kelz RR. Incidence of venous thromboembolism in patients undergoing surgical treatment for malignancy by type of neoplasm: An analysis of ACS-NSQIP data from 2005 to 2010. Surgery. 2012 Aug;152(2):186-92.
  10. Yang RL, Freeman K, Reinke CE, Fraker DL, Karakousis GC, Kelz RR, Doyle AM. Tertiary hyperparathyroidism in kidney transplant recipients: characteristics of patients selected for different treatment strategies. Transplantation 2012 Jul 15;94(1):70-6.
  11. Reinke CE, Hadler RA, Karakousis GC, Fraker DL, Kelz RR.  Does the presence of thyroid cancer increase the risk of venous thromboembolism in patients undergoing thyroidectomy? Surgery 2011 Dec; 150(6):1275-85.
  12. Shah PK; Shah KK; Karakousis GC; Reinke CE; Kelz RR; Fraker DL. Regional Recurrence after lymphadenectomy for clinically evident lymph node metastases from papillary thyroid cancer: a cohort study : Bulky nodal metastases in papillary thyroid cancer. Annals of Surgical Oncology 2011 Sep 13 (epub ahead of print).
  13. Katz, SC; Baldwin, K.; Karakousis, G.; Moraco, N,; Buglino, A.; Singer, S.; Brennan, MF. Soft tissue sarcoma diagnosed subsequent to lymphoma is associated with prior radiotherapy and decreased survival. Cancer 2011 April 4 (epub ahead of print).
  14. Karakousis, G.; Singer, S.; Zheng, J.; Gonen, M.; Coit, D.; DeMatteo, R.; Strong, V. Laparoscopic versus open gastric resections for primary gastrointestinal stromal tumors (GISTs): a size-matched comparison. Annals of Surgical Oncology 2011 Jun 18(6): 1599-605.
  15. Huang JH, Lee FS, Pasha TL, Sammel MD, Karakousis G, Xu G, Fraker D, Zhang PJ. Analysis of HIF-1alpha and its regulator, PHD2, in retroperitoneal sarcomas: Clinico-pathologic implications. Cancer Biology & Therapy 2010 Feb; 9(4):303-311.
  16. Karakousis, G., Fong Y. The Case for Selective Use of Pre-operative Chemotherapy for Hepatic Colorectal Metastases: More is not always Better. Annals of Surgical Oncology 2009 Aug 16(8): 2086-8.
  17. Xu, X.; Gimotty, P.A.; Guerry, D.; Karakousis, G.; Van Belle, P.; Liang, H.; Montone, K.; Pasha, T.; Ming, M.E.; Acs, G.; Feldman, M.; Barth, S.; Hammond, R.; Elenitsas, R.; Zhang, P.J.; Elder, D.E. Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Human Pathology 2008 Jun; 39(6): 901-9.
  18. Karakousis, G.; Han, D.; Rapaport Kelz, R.; Neemani, D.; Karamacharya, J.; Roses, R.; Fraker, D.  Interpretation of Intra-Operative PTH Changes in Patients with Multi-Glandular Primary Hyperparathyroidism (pHPT). Surgery 2007 Dec; 142(6): 845-50.
  19. Karakousis, G.; Gimotty, P.; Elder, D.; Ming, M.; Guerry, D.; Fraker, D.; Czerniecki, B.; Spitz, F. Regional Nodal Disease is Strongest Predictor of Survival in Patients with Thin Vertical Growth Phase Melanomas: A Case for SLN Staging Biopsy in these Patients. Annals of Surgical Oncology 2007 May; 14(5): 1596-603.
  20. Karakousis, G.; Gimotty, P.; Botbyl, J.; Kesmodel, S.; Elder, D.; Ming, M.; Guerry, D.; Fraker, D.; Czerniecki, B.; Spitz, F. Predictors of Regional Nodal Disease in Patients with Thin Melanomas. Annals of Surgical Oncology 2006 Apr; 13(4): 533-41.
  21. Kesmodel, S.; Karakousis, G.; Botbyl, J.; Canter, R.; Lewis, R.; Wahl, P.; Alavi, A.; Elder, D.; Ming, M.; Guerry, D.; Gimotty, P.; Fraker, D.; Czerniecki, B.; Spitz, F. Mitotic Rate as a Predictor of Sentinel Lymph Node Positivity in Patients with Thin Melanomas. Annals of Surgical Oncology 2005 Jun; 12(6): 449-58.
  22. Hendren, S.; Prabakaran, I.; Buerk, D.; Karakousis, G.; Feldman, M.; Spitz, F.; Menon, C.; Fraker, D. Interferon-beta Gene Therapy Improves Survival in an Immunocompetent Mouse Model of Carcinomatosis. 2004 Surgery Apr; 135(4): 427-36.
  23. Szeto, W.; Kreisel, D.; Karakousis, G.; Pochettino, A.; Sterman, D.; Kotloff, R.; Aracasoy, S.; Zisman, D.; Blumenthal, N.; Gallop, R.; Kaiser, L.; Bavaria, J.; Rosengard, B. Cardiopulmonary Bypass for Bilateral Sequential Lung Transplantation in Patients with Chronic Obstructive Pulmonary Disease without Adverse Effect on Lung Function or Clinical Outcome. J Thorac Cardiovasc Surg 2002 Aug; 124: 241-9.
  24. Karakousis, G.; Ye, N.; Li, Z.; Chiu, S.; Reddy, G.; Radding, C.  The Beta Protein of Phage Lambda Binds Preferentially to an Intermediate in DNA Renaturation. Journal of Molecular Biology 1998 Mar; 276(4): 721-731.
  25. Li, Z.; Karakousis, G.; Chiu, S.; Reddy, G.; Radding, C.  The Beta Protein of Phage Lambda Promotes Strand Exchange. Journal of Molecular Biology 1998 Mar; 276(4): 733-44.

Chapters and Reviews

  1. Karakousis, G. Fraker, DL. Isolated limb perfusion (ILP) and isolated limb infusion (ILI) for locally advanced melanoma.  Regional Therapeutics for Advanced MalignanciesJaypee Brothers Medical Publishers, 2012.
  2. Karakousis, G.; DeMatteo, R. Gastrointestinal tumors. Current Surgical Therapy, Cameron, J.L. et al (eds.). Elsevier Health Sciences, 2011.
  3. Karakousis, G.; Czerniecki, B. Diagnosis of Melanoma. PET Imaging in Melanoma; PET Clinics, Fuster, D., Rubello, R. (eds.) W.B. Saunders, 2011.
  4. Kingham, T.; Karakousis, G.; Ariyan, C. Randomized clinical trials in melanoma. Surg Oncol Clin N Am. 2010 Jan;19(1):13-31. Review.
  5. Karakousis, G.; Kelz, R.; Fraker, D. Thyroid, Parathyroid and Adrenal Glands in The
    Surgical Review (3rd ed.) Porrett, P. et al (eds.). Lippincott Williams & Wilkins, 2009.
  6. Karakousis, G, Fraker, D. Thyroidectomy and Parathyroidectomy in Gowned and Gloved Surgery: Introduction to Common Procedures ch. 20. Roses, R. et al (eds.) Elsevier Health Sciences, 2009.
  7. Karakousis, G.; Kelz, R.; Fraker, D. Thyroid, Parathyroid and Adrenal Glands in The Surgical Review (2nd ed.) Atluri, P.; Karakousis, G.; Porrett, P.; Kaiser, L. (eds.). Lippincott Williams & Wilkins, 2005.
  8. Karakousis, G.; Spitz, F. Surgical Approach to Gastric and Gastroesophageal Neoplasms in The Clinician's Guide to Gastrointestinal Oncology, ch. 4. Kochman, M. (ed.). Slack Incorporated, 2005.
  9. Karakousis, G.; Spitz, F. Surgical Approaches to Pancreatic Cancer in The Clinician's Guide to Pancreaticobiliary Diosrders, ch. 13.Ginsberg, G.; Amad, N. (eds.). Slack Incorporated, 2005.
Books
  1. Atluri P, Karakousis G, Porrett P, Kaiser L, editors. The Surgical Review, Second Edition. Philadelphia: Lippincott Williams & Wilkins, 2005.

Dr. Giorgos Karakousis

 
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