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Brendan J. Keating, PhD
Transplant Surgery

 
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Office:
Hospital of the University of PennsylvaniaPenn Transplant Institute
3400 Spruce Street, 2 Dulles
Philadelphia, PA 19104

bkeating@pennmedicine.upenn.edu

 

Brendan Keating, PhD, received his D.Phil. in molecular genetics from the Department of Clinical Medicine at University of Oxford, UK. He completed a post-doctoral fellowship at the Institute of Translational Medicine and Therapeutics at UPenn, and was a visiting Scientist at the Wellcome Trust Sanger Institute, Cambridge, UK. Dr. Keating has designed and developed genomic tools for cardiovascular related studies resulting in over a hundred genetic discoveries in various metabolic and CVD-related traits.

Dr. Keating joined the Faculty at Penn in 2012, and recently moved his primary appointment to the Division of Transplantation. His major research interests focus on the analyses of miRNA, mRNA and polymorphisms of donor and recipients genomes, with the aim of delivering individualized treatment of immunosuppression therapies post-transplant, and prediction of genetic signals that may underpin graft rejection and complications of rejection. Dr. Keating is Principal Investigator of genome-wide association studies (GWAS) for solid-organ transplant cohorts within the Children's Hospital of Philadelphia, and of urinary omic studies. He instigated the formation of an international genomics consortium (iGeneTRAIN) for large-scale genomic studies using > 45,000 DNA samples from a number of international transplant studies (www.igenetrain.org). Dr. Keating is also a member of the Pharmacogenomics and Return of Results working groups of the NHGRI electronic medical record and genomics (eMERGE) network which is integrating clinical genetic data into patient’s electronic medical records for clinical decision support for individualize dosing of patients. Dr. Keating has led or co-authored over 120 genomic publications and has given over 100 presentations in 25 countries including numerous national and international conferences. Dr. Keating is also PI of a prospective NIH-funded study looking at post-transplant outcomes in 12 North American pediatric renal transplant centers.

 
Faculty Appointments
2011 - present Research Assistant Professor of Pediatrics
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2011 - present Research Assistant Professor of Pediatrics in Surgery
Division of Transplant Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2011 - present  Faculty Member, Cell & Molecular Biology (CAMB) Graduate Group
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2011- 2012 Co-Director of BGI@CHOP Joint-Genome Center
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2009 - present   Lead Clinical Data Analyst, Center for Applied Genomics
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
Education/Training
2001 - 2005  PhD - Christ Church College, University of Oxford, United Kingdom
(Molecular Genetics) (Clinical Med. Dept., with lab work completed at the Wellcome Trust Center for Human Genetics)
 
1994 - 1997 BSc - University of Glasgow, United Kingdom (Genetics, with honors)
 
 
 
 
 
 
Memberships/Societies
 
Scientific Committees
2009 - present  Steering committee member for the International Scientific Advisory Committee for Cardiovascular Gene Annotation (British Heart Foundation, funded 2007-present)
 
 
 
 
 
 
 
Research
 
Research Publications, Peer Reviewed
  1. Knight JC, Keating BJ, Rockett KA, Kwiatkowski DP.  In vivo characterization of regulatory polymorphisms by allele specific quantification of RNA polymerase loading. Nature Genetics 33(4):469-475, Apr. 2003 (Epub Mar. 10, 2003)  PMID: 12627232
  2. Knight JC, Keating BJ, Kwiatkowski DP.  Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.  Nature Genetics 36(4):394-399, Apr. 2004 (Epub Mar. 28, 2004).  PMID: 15052269
  3. Hanchard N, Rockett K, Udalova I, Wilson J, Keating B, Koch O, Nijnik A, Diakite M, Herbert M, Kwiatkowski D.  An investigation of transmission ratio distortion in the central region of the human MHC.  Genes & Immunology 7(1):51-58, Jan. 2006.  PMID: 16341054
  4. Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, Wang Y, Keating BJ, Taylor JM, Hacking DF, Scerri T, Francks C, Richardson AJ, Wade-Martins R, Stein JF, Knight JC, Copp AJ, Loturco J, Monaco AP.  The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Human Molecular Genetics 15(10):1659-1666, May 15, 2006 (Epub Apr. 6, 2006).  PMID: 16600991
  5. Hanchard N, Diakite M, Koch O, Keating BJ, Pinder M, Pinder M, Jallow M, Sisay-Joof F, Nijnik A, Wilson J, Udalova I, Kwiatkowski D, Rockett K.  Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in human MHC class III.  Immunogenetics 58(5-6):465-470, June 2006 (Epub Apr. 28, 2006).  PMID: 16738941
  6. Wilson JN, Rockett K, Keating BJ, Jallow M, Pinder M, Sisay-Joof F, Newport M, Kwiatkowski D.  A hallmark of balancing selection is present at the promoter region of interleukin 10.  Genes & Immunology 7(8):680-683, Dec. 2006 (Epub Aug. 31, 2006).  PMID: 16943796
  7. Hull J, Campino S, Rowlands K, Chan MS, Copley RR, Rockett K, Elvidge G, Keating BJ, Knight J, Kwiatkowski D.  Identification of common genetic variation that modulates alternative splicing. PLoS Genetics 3(6):e99, June 2007.  PMID: 17571926
  8. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA.  Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS ONE 3(10):e3583, 2008 (Epub Oct. 31, 2008).  PMID: 18974833
  9. Fairfax BP, Vannberg F, Radhakrishnan J, Hakonarson H, Keating BJ, Hill AV, Knight JC.  An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. Human Molecular Genetics 19(4):720-730, Feb. 15, 2010 (Epub Nov. 26, 2009).  PMID: 19942621
  10. Cappola TP, Li M, He J, Ky B, Gilmore J, Qu L, Keating BJ, Reilly M, Kim CE, Frackelton E, Hakonarson H, Syed F, Hindes A, Matkovich SJ, Cresci S, Dorn GW 2nd. Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circulation Cardiovascular Genetics 3(2):147-154, Apr. 2010 (Epub Feb. 2, 2010). PMID: 20124441
  11. Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Che MH, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh CH, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA Jr, Tracy RP, Vasan RS, Wilson JG, Kathiresan S, Fabsitz RR, Boerwinkle E, Gabriel SB.  Candidate Gene Association Resource (CARe): Design, methods, and proof of concept.  Circulation Cardiovascular Genetics 3(3):267-275, June 1, 2010 (Epub Apr. 17, 2010).  PMID: 20400780
  12. Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.  BMC Medical Genetics 11:96, June 14, 2010.  PMID: 20546612
  13. Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ, Mills TC, Srivastava A, Rudko A, Freidin MB, Puzyrev VP, Garg VK, Roy S, Meisner S, Hazra SK, Saha B, Floyd S, Keating BJ, Kim C, Fairfax BP, Knight JC, Hill PC, Adegbola RA, Hakonarson H, Fine PE, Pitchappan RM, Bamezai RN, Hill AV, Vannberg FO.  Leprosy and the adaptation of human toll-like receptor 1.  PLoS Pathogen 6:e1000979, July 1, 2010.  PMID: 20617178
  14. Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD.  Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arteriosclerosis Thrombosis & Vascular Biology 30(12):2648-2654, Dec. 2010 (Epub Sept. 16, 2010).  PMID: 20847308
  15. Lo KS, Wilson JG, Lange LA, Folsom AR, Galarneau G, Ganesh SK, Grant SF, Keating BJ,  McCarroll SA, Mohler ER, O'Donnell CJ, Palmas W, Tang W, Tracy RP, Reiner AP, Lettre G.  Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. Human Genetics 129(3):307-317, Mar. 2011 (Epub Dec. 12, 2010).   PMID: 21153663
  16. Wassel CL, Lange LA, Keating BJ, Tang W, Yun Li, Aaron R. Johnson AD, Smith N, Delaney C, Larkin E, Redline S, Green D, Taylor H, O’Donnell CJ Reiner AP. Association of genomic loci from a 50K candidate gene chip with fibrinogen levels among European Americans and African-Americans from six cohort studies: The Candidate Gene Association Resource (CARe). Blood 117(1):268-275, Jan. 6, 2011 (Epub Oct. 26, 2010).  PMID: 20978265
  17. Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, M Maloney C, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, J Meyer N, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, D Christie J, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H*, Keating BJ* (corresponding author).  Meta-analysis of gene-centric association studies identifies new genes for adult height. American Journal of Human Genetics 88(1):6-18, Jan. 7, 2011 (Epub Dec. 30, 2010).  PMID: 21194676
  18. Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Döring A, Thorand B, Li  M, Reilly MP, Koenig W, Samani NJ, Rader DJ. Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circulation Cardiovascular Genetics 4(2):145-155, Apr. 1, 2011 (Epub Feb. 8, 2011).  PMID: 21303902
  19. Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE, Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner AP, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick DS, Tang WH, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG, Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: The NHLBI CARe Project.  PLoS Genetics 7(2):e1001300, Feb. 10, 2011.  PMID: 21347282
  20. Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; The International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Chakravarti A, Zhu X, Levy D.  Association of genetic variation with systolic and diastolic blood pressure among African Americans:  The Candidate Gene Association Resource (CARe) Study.  Human Molecular Genetics 20(11):2273-2284, June 1, 2011 (Epub Mar. 4, 2011).  PMID: 21378095
  21. Zhu X, Young JH, Fox E, Keating BJ, Franceschini N, Kang S, Tayo B, Adeyemo A, Sun YV, Li Y, Morrison A, Newton-Cheh C, Liu K, Ganesh SK, Kutlar A, Vasan RS, Dreisbach A, Wyatt S, Polak J, Palmas W, Musani S, Taylor H, Fabsitz R, Townsend RR, Dries D, Glessner J, Chiang CW, Mosley T, Kardia S, Curb D, Hirschhorn JN, Rotimi C, Reiner A, Eaton C, Rotter JI, Cooper RS, Redline S, Chakravarti A, Levy D.  Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: Contributions from the CARe consortium. Human Molecular Genetics 20(11):2285-2295. June 1, 2011 (Epub Mar. 21, 2011).  PMID: 21422096
  22. Bhushan B, Khalyfa A, Spruyt K, Kheirandish-Gozal L, Sans Capdevila O, Bhattacharjee R, Kim J, Keating BJ, Hakonarson H, Gozal D.  Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea. Sleep Medicine 12(7):666-671, Aug. 2011 (Epub June 12, 2011).  PMID: 21664182
  23. Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, Smith NL, Delaney JA, Kumari M, Hingorani A, North KE, Kivimaki M, Tracy RP, O’Donnell CJ, Folsom AR, Green D, Humphries S, Reiner AP.  A gene-centric association scan for coagulation factor VII (FVII) levels in European and African Americans: The Candidate Gene Association Resource (CARe) Consortium.  Human Molecular Genetics 20(17):3525-3534, Sept. 1, 2011 (Epub June 15, 2011).  PMID: 21676895
  24. Reiner AP, Lettre G, Nalls MA, Ganesh SK, Mathias R, Austin MA, Dean E, Arepalli S, Britton A, Chen Z, Couper D, Curb JD, Eaton CB, Fornage M, Grant SF, Harris TB, Hernandez D, Kamatini N, Keating BJ, Kubo M, LaCroix A, Lange LA, Liu S, Lohman K, Meng Y, Mohler ER 3rd, Musani S, Nakamura Y, O'Donnell CJ, Okada Y, Palmer CD, Papanicolaou GJ, Patel KV, Singleton AB, Takahashi A, Tang H, Taylor HA Jr, Taylor K, Thomson C, Yanek LR, Yang L, Ziv E, Zonderman AB, Folsom AR, Evans MK, Liu Y, Becker DM, Snively BM, Wilson JG.  Genome-wide association study of white blood cell count in 16,388 African Americans: The Continental Origins and Genetic Epidemiology Network (COGENT).  PLoS Genetics 7(6):e1002108, June 2011 (Epub June 30, 2011). PMID: 21738479
  25. Smith EN, Koller DL, Panganiban C, Szelinger S, Zhang P, Badner JA, Barrett TB, Berrettini WH, Bloss CS, Byerley W, Coryell W, Edenberg HJ, Foroud T, Gershon ES, Greenwood TA, Guo Y, Hipolito M, Keating BJ, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, McKinney R, Murray SS, Nievergelt CM, Nurnberger JI Jr, Nwulia EA, Potash JB, Rice J, Schulze TG, Scheftner WA, Shilling PD, Zandi PP, Zöllner S, Craig DW, Schork NJ, Kelsoe JR.  Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genetics 7(6):e1002134, June 2011 (Epub June 30, 2011).  PMID: 21738484
  26. Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating BJ, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X, Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA Jr, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR.  The landscape of recombination in African Americans. Nature 476(7359):170-175, July 20, 2011.  PMID: 21775986
  27. N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Adeyemo A, Adoue V, Ambrosone CB, Atwood L, Bandera EV, Becker LC, Berndt SI, Bernstein L, Blot WJ, Boerwinkle E, Britton A, Casey G, Chanock SJ, Demerath E, Deming SL, Diver WR, Fox C, Harris TB, Hernandez DG, Hu JJ, Ingles SA, John EM, Johnson C, Keating BJ, Kittles RA, Kolonel LN, Kritchevsky SB, Le Marchand L, Lohman K, Liu J, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, North KE, Nyante S, Ogunniyi A, Ostrander EA, Papanicolaou G, Patel S, Pettaway CA, Press MF, Redline S, Rodriguez-Gil JL, Rotimi C, Rybicki BA, Salako B, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Stram AH, Stram DO, Strom SS, Suktitipat B, Thun MJ, Witte JS, Yanek LR, Ziegler RG, Zheng W, Zhu X, Zmuda JM, Zonderman AB, Evans MK, Liu Y, Becker DM, Cooper RS, Pastinen T, Henderson BE, Hirschhorn JN, Lettre G, Haiman CA.  Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry. PLoS Genetics 7(10):e1002298, Oct. 2011 (Epub Oct. 6, 2011). PMID: 21998595
  28. Saxena R†, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM; Look AHEAD Research Group; DIAGRAM consortium, Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW 2nd, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ †(† corresponding author).  Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics 90(3):410-425, Mar. 9, 2012 (Epub Feb. 9, 2012).  PMID: 22325160
  29. The Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium. DI Swerdlow, MV Holmes, KB Kuchenbaecker, JE Engmann, T Shah, R Sofat, Y Guo, C Chung, A Peasey, R Pfister, SP Mooijaart, HA Ireland, M Leusink, C Langenberg, K Li, J Palmen, P Howard, JA Cooper, F Drenos, J Hardy, MA Nalls, YR Li, G Lowe, M Stewart, SJ Bielinski, J Peto, NJ Timpson, J Gallacher, M Dunlop, R Houlston, I Tomlinson, I Tzoulaki, J Luan, JM Boer, NG Forouhi, NC Onland-Moret, YT van der Schouw, RB Schnabel, JA Hubacek, R Kubinova, M Baceviciene, A Tamosiunas, A Pajak, R Topor-Madry, S Malyutina, D Baldassarre, B Sennblad, E Tremoli, U de Faire, L Ferrucci, S Bandenelli, T Tanaka, JF Meschia, A Singleton, G Navis, I Mateo Leach, SJ Bakker, RT Gansevoort, I Ford, SE Epstein, MS Burnett, JM Devaney, JW Jukema, RG Westendorp, GJ de Borst, Y van der Graaf, PA de Jong, AH Maitland-van der Zee, OH Klungel, A de Boer, PA Doevendans, JW Stephens, CB Eaton, JG Robinson, JE Manson, FG Fowkes, TM Frayling, JF Price, PH Whincup, RW Morris, DA Lawlor, GD Smith, Y Ben-Shlomo, S Redline, LA Lange, M Kumari, NJ Wareham, WM Verschuren, EJ Benjamin, JC Whittaker, A Hamsten, F Dudbridge, JA Delaney, A Wong, D Kuh, R Hardy, BA Castillo, JJ Connolly, P van der Harst, EJ Brunner, MG Marmot, CL Wassel, SE Humphries, PJ Talmud, M Kivimaki, FW Asselbergs, M Voevoda, M Bobak, H Pikhart, JG Wilson, H Hakonarson, AP Reiner, BJ Keating, N Sattar, Hingorani A, Casas JP.  The interleukin-6 receptor as a target for prevention of coronary heart disease: A Mendelian randomisation analysis. Lancet 379(9822):1214-1224, Mar. 31, 2012.  PMID: 22421340
  30. Chiang CWK, Liu CT, Lettre G, Lange LA, Jorgensen NW, Keating BJ, Vedantam S, Nock NL, Franceschini N, Reiner AP, Demerath EW, Boerwinkle E, Rotter JI, Wilson JG, North KE, Papanicolaou GJ, GIANT consortium, Murabito JM, Hirschhorn JN. Ultraconserved elements in the human genome: Association and transmission analyses of highly constrained SNPs. Genetics 192(1):253-266, Sept. 2012 (Epub June 19, 2012). PMID: 22714408
  31. Fischer WE, Cruickshanks KJ, Pinto A, Schubert CR, MS, Klein BEK, Klein R, Nieto FJ, Pankow JS, Snyder DJ, Keating BJ. Intensity of salt taste and hypertension.  Chemosensory Perception 5(2):139-145, June 1, 2012 (Epub Jan. 20, 2012). PMID: 22745848
  32. Guo Y, Lanktree MB, Taylor KC, IBC 50K SNP array BMI Consortium. Hakonarson H, Lange LA, Keating BJ†; († corresponding author). Gene-centric meta-analysis of up to 108,308 individuals confirms numerous known Body Mass Index loci and reveals novel signals. Human Molecular Genetics 22(1):184-201, Jan. 1, 2013 (Epub Sept. 21, 2012).  PMID: 23001569
  33. Wang K, Zhang H, Mentch FD, Bradfield JP, Glessner JT, Qiu H, Guo Y, Hou C, Frackelton EC, Thomas K, Bender A, Albano A, Otieno G, Garris M, Seidler K, Moy A,  Kim CE, Keating BJ, Grundmeier R, Sleiman P, Grant SFA, Hakonarson H.  Examination of genetic variants influencing lipid traits in pediatric populations. Journal of Pediatric Genetics 1(2):85-98, 2012.
  34. Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ*, Drenos F†*.  Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics 91(5):823-838, Nov. 2, 2012 (Epub Oct. 11, 2012).  PMID: 23063622. (*equal contribution and co corresponding author).
  35. Fjell AM, Walhovd KB, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Venkatraman V, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Darst BF, Schork NJ, Casey BJ, Chang L, Ernst TM, Gruen JR, Kaufmann WE, Kenet T, Frazier J, Murray SS, Sowell ER, van Zijl P, Mostofsky S, Jernigan TL, Dale AM Jernigan TL, McCabe C, Chang L, Akshoomoff N, Newman E, Dale AM, Ernst T, Dale AM, Van Zijl P, Kuperman J, Murray S, Bloss C, Schork NJ, Appelbaum M, Gamst A, Thompson W, Bartsch H, Jernigan TL, Dale AM, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey BJ, Ruberry EJ, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, Gruen J.  Neurocognition, and Genetics Study. Multimodal imaging of the self-regulating developing brain. Proceedings of the National Academy of Science USA 109(48):19620-19625, Nov. 27, 2012 (Epub Nov. 12, 2012). PMID: 23150548
  36. Walhovd KB, Fjell AM, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst TM, Frazier J, Gruen JR, Kaufmann WE, Murray SS, van Zijl P, Mostofsky S, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study. Jernigan TL, McCabe C, Chang L, Akshoomoff N, Newman E, Dale AM, Ernst T, Dale AM, Van Zijl P, Kuperman J, Murray S, Bloss C, Schork NJ, Appelbaum M, Gamst A, Thompson W, Bartsch H, Jernigan TL, Dale AM, Akshoomoff N, Chang L, Ernst T, Keating BJ, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey BJ, Ruberry EJ, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, Gruen J.  Long-term influence of normal variation in neonatal characteristics on human brain development. Proceedings of the National Academy of Science USA 109(49):20089-20094. Dec. 4, 2012 (Epub Nov. 19, 2012). PMID: 23169628
  37. Keating B†, Bansal AT, Walsh S, Millman J, Newman J, Kidd K, Budowle B, Eisenberg A, Donfack J, Gasparini P, Budimlija Z, Henders AK, Chandrupatla H, Duffy DL, Gordon SD, Hysi P, Liu F, Medland SE, Rubin L, Martin NG, Spector TD, Kayser M†; International Visible Trait Genetics (VisiGen) Consortium.  Design & implementation of a large-scale genetic marker panel for prediction of external visible traits, kinship, identity and ancestry in humans.  International Journal of Legal Medicine 127(3):559-572, May 2013 (Epub Nov. 13, 2012). († corresponding author)  PMID: 23149900
  38. Butler AM, Evans DS, Nalls MA, Smith EN, Tanaka T, Yin X, Li G, Buxbaum, Whitsel EA, Albert CM, Alonso A, Arking DE, Benjamin EJ, Berenson GS, Bis JC, Chen W, Deo R, Ellinor PT, Fox ER, Heckbert SR, Heiss G, Hsueh WC, Keating BJ, Kerr BF, Li Y, Limacher MC, Liu Y, Lubitz SA, Marciante KD, Mehra R, Meng YA, Musani SK, Newman AB, Newton-Cheh C, North KE, Palmer CD, Psaty BM, Quibrera PM, Redline S, Reiner AP, Rotter JI, Schnabel RB, Schork NJ, Singleton AB, Smith JG, Soliman EZ, Srinivasan SR, Zhang Z, Zonderman AB, Ferrucci L, Murray SS, Evans MK, Sotoodehnia N, Magnani JW, Avery CL.  Novel loci associated with PR interval in a genome-wide association study of ten African American cohorts.  Circulation Cardiovascular Genetics 5(6):639-646, Dec. 2012 (Epub Nov. 8, 2012).  PMID: 23139255
  39. Elbers CC, Guo Y, Tragante V, van Iperen EP, Lanktree MB, Castillo BA, Chen F, Yanek LR, Wojczynski MK, Li YR, Ferwerda B, Ballantyne CM, Buxbaum SG, Chen YD, Chen WM, Cupples LA, Cushman M, Duan Y, Duggan D, Evans MK, Fernandes JK, Fornage M, Garcia M, Garvey WT, Glazer N, Gomez F, Harris TB, Halder I, Howard VJ, Keller MF, Kamboh MI, Kooperberg C, Kritchevsky SB, LaCroix A, Liu K, Liu Y, Musunuru K, Newman AB, Onland-Moret NC, Ordovas J, Peter I, Post W, Redline S, Reis SE, Saxena R, Schreiner PJ, Volcik KA, Wang X, Yusuf S, Zonderland AB, Anand SS, Becker DM, Psaty B, Rader DJ, Reiner AP, Rich SS, Rotter JI, Sale MM, Tsai MY, Borecki IB, Hegele RA, Kathiresan S, Nalls MA, Taylor HA Jr, Hakonarson H, Sivapalaratnam S, Asselbergs FW, Drenos F, Wilson JG, Keating BJ. † Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. PLoS One 7(12):e50198, 2012 (Epub Dec. 7, 2012). († corresponding author) PMID: 23236364
  40. Glessner JT, Smith AV, Panossian S, Kim CE, Takahashi N, Thomas KA, Wang F, Seidler K, Harris TB, Launer LJ, Keating BJ, Connolly J, Sleiman PM, Buxbaum JD, Grant SF, Gudnason V, Hakonarson H.  Copy number variations in alternative splicing gene networks impact lifespan.  PLoS One 8(1): e53846, Jan. 2013 (Epub Jan. 30, 2013).  PMID: 23382853
  41. Chen Z, Tang H, Qayyum R, Schick UM, Nalls MA, Handsaker R, Li J, Lu Y, Yanek LR, Keating BJ, Meng Y, van Rooij FJ, Okada Y, Kubo M, Rasmussen-Torvik L, Keller MF, Lange L, Evans M, Bottinger EP, Linderman MD, Ruderfer DM, Hakonarson H, Papanicolaou G, Zonderman AB, Gottesman O; BioBank Japan Project, CHARGE Consortium, Thomson C, Ziv E, Singleton AB, Loos RJ, Sleiman PM, Ganesh S, McCarroll S, Becker DM, Wilson JG, Lettre G, Reiner AP. Genome-wide association analysis of red blood cell traits in African Americans: The COGENT Network.  Human Molecular Genetics Mar. 3, 2013 (Epub Feb. 26, 2013). PMID: 23446634
  42. Ganesh SK, Tragante V, Guo W, Guo Y, Smith EN, Lanktree MB, Franceschini N,  Johnson T, Castillo BA, Barnard J, Baumert J, Chang YC, de Jong JS, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MFL, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EPA, van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JMA, Burkley B, Burt A, Chen W, Cooper-DeHoff RM, Curtis SP, Dichgans M, Dreisbach A, Duggan D, Ehret GB, Fabsitz R, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, LaCroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine BJ, Pettinger M, Polak J, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Vasan R, Monique W,  Bezzina CR, Boehm BO, Boerwinkle E, Caulfield MJ, Chakravarti A, Chasman DI,  Davidson KW, Doevendans PA, FitzGerald GA, Gums JG, Koenig W, LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Munroe PB, de Bakker PIW, Zhu X*, Levy D*, Keating BJ *†, Asselbergs FW† * (*equally contribution † Corresponding author).  Loci influencing blood pressure identified using a cardiovascular gene-centric array.  Human Molecular Genetics 22(8):1663-1678, Apr. 15, 2013. PMID: 23303523
  43. Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM,
  44. Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB; NABEC Consortium; UKBEC Consortium; BioBank Japan Project; AGEN Consortium, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA.  A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.  Nature Genetics 45(6):690-696, June 2013 (Epub Apr. 14, 2013). PMID: 23583978
  45. Shi L, Zhang X, Golhar R, Otieno FG, He M, Hou C, Kim C, Keating BJ, Lyon GJ, Wang K, Hakonarson H.   Whole-genome sequencing in an autism multiplex family. Molecular Autism 4(1):8, Apr. 18, 2013.  PMID: 23597238
  46. Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, Ojeda F, Müller-Nurasyid M, Munzel TF, Psaty BM, Rice K, Rotter JI, Schnabel RB, Tang WH, Thorand B, Erdmann J; CARDIoGRAM Consortium, Jacobs DR Jr, Wilson JG, Koenig W, Tracy RP, Blankenberg S, März W, Gross MD, Benjamin EJ, Hazen SL, Allayee H. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the CHARGE and CARe Consortia.  Human Molecular Genetics 22(16):3381-3393, Aug. 15, 2013 (Epub Apr. 24, 2013).  PMID: 23620142
  47. Martignetti JA1, Tian L, Li D, Ramirez MC, Camacho-Vanegas O, Camacho SC, Guo Y, Zand DJ, Bernstein AM, Masur SK, Kim CE, Otieno FG, Hou C, Abdel-Magid N, Tweddale B, Metry D, Fournet JC, Papp E, McPherson EW, Zabel C, Vaksmann G, Morisot C, Keating B, Sleiman PM, Cleveland JA, Everman DB, Zackai E, Hakonarson H. Mutations in pdgfrb cause autosomal-dominant infantile myofibromatosis. American Journal of Human Genetics 92(6):1001-1007, June 6, 2013 (Epub May 23, 2013). PMID: 23731542
  48. Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EP, Li M, Leusink M, Trompet S, Verschuren JJ, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JM, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day IN, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der Zee AH, Khaw KT, Keating BJ, van der Harst P, Price JF, Mehta SR, Yusuf S, Witteman JC, Franco OH, Jukema JW, de Knijff P, Tybjaerg-Hansen A, Rader DJ, Farrall M, Samani NJ, Kivimaki M, Fox KA, Humphries SE, Anderson JL, Boekholdt SM, Palmer TM, Eriksson P, Paré G, Hingorani AD, Sabatine MS, Mallat Z, Casas JP, Talmud PJ.  Secretory phospholipase A(2)-IIA and cardiovascular disease: A mendelian randomization study.  Journal of the American College of Cardiology 62(21):1966-1976, Nov. 19, 2013 (Epub July 31, 2013)  PMID: 23916927
  49. Best LG, Saxena R, Anderson CM, Barnes MR, Hakonarson H, Falcon G, Martin C, Castillo BA, Karumanchi A, Keplin K, Pearson N, Lamb F, Bercier S, Keating BJ.  Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population.  PLoS One 8(8):e71231, Aug. 5, 2013. PMID: 24116239
  50. Franceschini N†, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK, Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, Bochud M, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM, Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME, Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH, Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G, Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D, Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W, Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E, Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ, Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, Snyder M; Asian Genetic Epidemiology Network Consortium, Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC, Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI, Chakravarti A, Reiner AP, Levy D*, Keating BJ*, Zhu X *.  Discovery and fine-mapping of blood pressure genetic loci in multiple ethnic groups with a focus on African Ancestry: The Continental Origins and Genetic Epidemiology Network (COGENT). American Journal of Human Genetics 93(3):545-554, Sept. 5, 2013 (Epub Aug. 22, 2013). PMID: 23972371 (* equal contributing author)
  51. Best LG, Anderson CM, Saxena R, Almoguera B, Chandrupatla H, Martin C, Falcon G, Keplin K, Pearson N, Keating BJ.  IBC CARe microarray allelic population prevalences in an American Indian population.  PLoS One 8(9): e75080, Sept. 6, 2013.  PMID: 24040389
  52. Yoneyama S*, Guo Y*, Lanktree M*, Barnes MR, Elbers CC, Baumert J, Chen W, Gaunt TR, Gong Y, Johnson T, Lamont M, Monda KL, Onland-Moret C, Nelson CP, Peter I, Rafelt S, Shaffer J, Shen H, Smith E, Anand SS, Davidson K, Heid I, Hofker MH, Illig T, Johnson JA, König W, McCaffery J, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Reilly SRM, Samani N, Wijmenga C, the CARe IBC Consortium, Demerath EW, Fox CS, Hakonarson H, North KE, Reiner AP, Keating B†, Taylor KC†.  Gene-centric meta-analyses for central adiposity traits using up to 51,990 individuals of European descent confirms known loci and reveal several novel associations. Human Molecular Genetics 23(9):2498-2510, May 1, 2014 (Epub Dec. 17, 2013). PMID: 24345515 († corresponding author)
  53. Holmes MV†, Lange LA, Palmer T, Lanktree MB, North KE, Almoguera B, Buxbaum S, Chandrupatla HR, Elbers CC, Guo Y, Hoogeveen RC, Li J, Li YR, Swerdlow DI, Cushman M, Price TS, Curtis SP, Fornage M, Hakonarson H, Patel SR, Redline S, Siscovick DS, Tsai MY, Wilson JG, van der Schouw YT, Fitzgerald GA, Hingorani AD, Casas JP, de Bakker PI, Rich SS, Schadt EE, Asselbergs FW, Reiner AP, Keating BJ†. Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. American Journal of Human Genetics 94(2):198-208, Feb. 6, 2014 (Epub Jan. 23, 2014).  PMID: 24462370 († corresponding author)
  54. Holmes MV*, Asselbergs FW*, Palmer TM*, Drenos F, Lanktree MB, Nelson C, Dale CE, Finan C, Swerdlow DI, Tragante V, van Iperen EPA, Sivapalaratnam S, Shah S, Elbers CC, Shah T, Engmann J, Kumari M, Giambartolomei C, White J, Zabaneh D, Sofat R, Masle S on behalf of the UCLEB consortium, North KE, Castillo BA, Hoogeveen RC, Cushman M, Fornage M, Patel SR, Redline S, Siscovick DS, Tsai MY, Karczewski KJ, Hofker M, Verschuren M, Bots M, van der Schouw Y, Melander O, Dominiczak AF, Morris R, Ben-Shlomo Y, Cupples LA, Padmanabhan S, Price J, Baeumert J, Peters A, Thorand B, Koenig W, Gaunt T, Humphries SE, Clarke R, Watkins H, Farrall M, Wilson JG, Rich SS, de Bakker PIW, Lange LA, Reiner AP, Dudbridge F, Samani N, Talmud PJ, Kivimaki M, Lawlor DA, Keating BJ *, Hingorani AD*, Casas JP*.  Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal 36(9):539-550, Mar. 1, 2015 (Epub Jan. 27, 2014).  PMID: 24474739
  55. Guo Y, Prokudin I, Yu C, Liang J, Xie Y, Flaherty M, Tan L, Crofts S, Wang F, Snyder J, Donaldson C, Abdel-Magid N, Vazquez L, Keating B, Hakonarson H, Wang J, Jamieson RV*.  Advantage of whole exome sequencing over allele-specific and targeted segment sequencing, in detection of novel TULP1 mutation in Leber congenital amaurosis. Ophthalmic Genetics 1-6, Aug. 21, 2015 (Epub Feb. 19, 2014).  PMID: 24547928
  56. Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JM, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Melander O, Nelson CP, Nolte IM, Pankratz N, Price TS, Shaffer J, Shah S, Tomaszewski M, van der Most PJ, Van Iperen EP, Vonk JM, Witkowska K, Wong CO, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Brown M, Burt A, Cooper-Dehoff RM, Connell JM, Cruickshanks KJ, Curtis SP, Davey-Smith G, Delles C, Gansevoort RT, Guo X, Haiqing S, Hastie CE, Hofker MH, Hovingh GK, Kim DS, Kirkland SA, Klein BE, Klein R, Li YR, Maiwald S, Newton-Cheh C, O'Brien ET, Onland-Moret NC, Palmas W, Parsa A, Penninx BW, Pettinger M, Vasan RS, Ranchalis JE, M Ridker P, Rose LM, Sever P, Shimbo D, Steele L, Stolk RP, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Wyatt S, Young JH, Zwinderman AH, Bezzina CR, Boerwinkle E, Casas JP, Caulfield MJ, Chakravarti A, Chasman DI, Davidson KW, Doevendans PA, Dominiczak AF, Fitzgerald GA, Gums JG, Fornage M, Hakonarson H, Halder I, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, Kumari M, März W, Murray SS, O'Connell JR, Oldehinkel AJ, Pankow JS, Rader DJ, Redline S, Reilly MP, Schadt EE, Kottke-Marchant K, Snieder H, Snyder M, Stanton AV, Tobin MD, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Watkins H, Johnson AD, Reiner AP, Zhu X, de Bakker PI, Levy D *, Asselbergs FW*†, Munroe PB *†, Keating BJ*†, († Corresponding author).  Discovery of eleven new loci influencing blood pressure in over 155,000 individuals of European ancestry from 37 studies. American Journal of Human Genetics 94(3):349-360, Mar. 6, 2014 (Epub Feb. 20, 2014).  PMID: 24560520
  57. Holmes MV, Exeter HJ, Folkersen L, Nelson CP, Guardiola M, Cooper JA, Sofat R, Boekholdt SM, Khaw KT, Li KW, Smith AJ, Van't Hooft F, Eriksson P, Franco-Cereceda A, Asselbergs FW, Boer JM, Onland-Moret NC, Hofker M, Erdmann J, Kivimaki M, Kumari M, Reiner AP, Keating BJ, Humphries SE, Hingorani AD, Mallat Z, Samani NJ, Talmud PJ; CARDIoGRAM Consortium.  Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.  Circulation Cardiovascular Genetics 7(2):144-150, Apr. 1, 2014 (Epub Feb. 21, 2014).  PMID: 24563418
  58. Ellis J, Lange EM, Li J, Dupuis J, Baumert J, Walston JD, Keating BJ, Durda P, Fox ER, Palmer CD, Meng YA, Young T, Farlow DN, Schnabel RB, Marzi CS, Larkin E, Martin LW, Bis JC, Auer P, Ramachandran VS, Gabriel SB, Willis MS, Pankow JS, Papanicolaou GJ, Rotter JI, Ballantyne CM, Gross MD, Lettre G, Wilson JG, Peters U, Koenig W, Tracy RP, Redline S, Reiner AP, Benjamin EJ, Lange LA.  Large multiethnic Candidate Gene Study for C-reactive protein levels: Identification of a novel association at CD36 in African Americans.  Human Genetics 133(8):985-995, Aug. 2014 (Epub Mar. 19, 2014).  PMID: 24643644
  59. Kullo IJ, Haddad R, Prows CA, Holm I, Sanderson SC, Garrison NA, Sharp RR, Smith ME, Kuivaniemi H, Bottinger EP, Connolly JJ, Keating BJ, McCarty CA, Williams MS, Jarvik GP.  Return of results in the genomic medicine projects of the eMERGE network.  Frontiers in Genetics 5:50, Mar. 26, 2014.  PMID: 24723935
  60. Holmes MV, Kuchenbaecker KB, Swerdlow DI, Shah T, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, van der Schouw YT, Schnabel RB, Jukema JW, Westendorp RGJ, Jan de Borst G, van der Graaf Y, de Jong PA, Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FGR, Frayling TM, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Redline S, Lange LA, Kumari M, Wareham NJ, Verschuren WMM, Benjamin EJ, Whittaker JC, Hamsten A, Dudbridge F, Delaney JAC, Wong A, Kuh D, Hardy R, Castillo BA, Hakonarson H, van der Harst P, Brunner EJ, Marmot MG, Wassel CL, Humphries SE, Talmud PJ, Kivimaki M, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Casas JP, Hingorani A.  Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. British Medical Journal 349:g4164, July 10, 2014. PMID: 25011450
  61. Prokudin I, Li D, He S, Guo Y, Goodwin L, Wilson M, Rose L, Tian L, Chen Y, Liang J, Keating B, Xu X, Jamieson RV, Hakonarson H.  Value of whole exome sequencing for syndromic retinal dystrophy diagnosis in young patients. Clinical & Experimental Ophthalmology  Epub July 24, 2014.  PMID: 25060287
  62. Keller MF, Reiner AP, Okada Y, van Rooij FJ, Johnson AD, Chen MH, Smith AV, Morris AP, Tanaka T, Ferrucci L, Zonderman AB, Lettre G, Harris T, Garcia M, Bandinelli S, Qayyum R, Yanek LR, Becker DM, Becker LC, Kooperberg C, Keating B, Reis J, Tang H, Boerwinkle E, Hofman A, Uitterlinden AG, van Duijn CM, Franco OH, Longo DL, Singleton AB, Psaty BM, Evans MK, Cupples LA, Rotter JI, O'Donnell CJ, Takahashi A, Wilson JG, Ganesh SK, Nalls MA; for the CHARGE Hematology, COGENT, and Bio-Bank Japan Project (RIKEN) Working Groups.  Trans-ethnic meta-analysis of white blood cell phenotypes.  Human Molecular Genetics  23(25):6944-6960, Dec. 20, 2014 (Epub Aug. 5, 2014).  PMID: 25096241
  63. Holmes MV, Frikke-Schmidt R, Melis D, Luben R, Asselbergs FW, Boer JM, Cooper J, Palmen J, Horvat P, Engmann J, Li KW, Onland-Moret NC, Hofker MH, Kumari M, Keating BJ, Hubacek JA, Adamkova V, Kubinova R, Bobak M, Khaw KT, Nordestgaard BG, Wareham N, Humphries SE, Langenberg C, Tybjaerg-Hansen A, Talmud PJ. A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease. Atherosclerosis 237(1):5-12, Nov. 2014 (Epub Aug. 15, 2014). PMID: 25173947
  64. Silverwood RJ, Holmes MV, Dale CE, Lawlor DA, Whittaker JC, Smith GD, Leon DA, Palmer T, Keating BJ, Zuccolo L, Casas JP, Dudbridge F.  Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: Application to alcohol and cardiovascular traits.  International Journal of Epidemiology 43(6):1781-1790, Dec. 2014 (Epub Sept. 5, 2014). PMID: 25192829
  65. Guo Y, Kartawinata M, Li J, Pickett HA, Teo J, Kilo T, Barbaro PM, Keating B, Chen Y, Tian L, Al-Odaib A, Reddel RR, Christodoulou J, Xu X, Hakonarson H, Bryan TM. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood  Epub Sept. 9, 2014.  PMID: 25205116
  66. Swerdlow D*, Preiss D*, Kuchenbaeker K, Holmes M, Engmann J, Shah T, Sofat R, Stender S, Johnson P, Scott R, Leusink M, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper J, Drenos F, Li Y, Lowe G, Gallacher J, Stewart M, Tzoulaki I, Buxbaum S, Boer J, Forouhi N, Onland-Moret NC, van der Schouw Y, Schnabel R, Hubacek J, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Westendorp R, Jan de Borst G, van der Graaf Y, de Jong P, Maitland-van der Zee AH, Klungel O, de Boer A, Doevendans P, Eaton C, DIAGRAM Consortium, MAGIC Consortium, Robinson J, Kjekshus J, Fowkes FG, Gotto A, Keech A, Marchioli R, Tognoni G, Sever P, Poulter N, Waters D, Pedersen T, Amarenco P, Nakamura H, Kumari M, Wareham N, Verschuren WMM, Redline S, Whittaker J, Hamsten A,  Delaney JA, Gaunt T, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, Brunner E, Tybjaerg-Hansen A, Marmot M, Krauss R, Tsai M, Hoogeveen R, Lange L, Hakonarson H, Humphries S, Talmud P, Kivimaki M, Timpson N, Langenberg C, Asselbergs F, Voevoda M, Bobak M, Pikhart H, Wilson J, Reiner A, Keating BJ, Hingorani A, Sattar N.   HMGCR, body weight and type 2 diabetes in Mendelian randomization analysis and statin trials. Lancet 385(9965):351-361, Jan. 24, 2015 (Epub Sept. 24, 2014). PMID: 25262344
  67. Crosslin DR, Carrell DS, Burt A, Kim DS, Underwood J, Hanna DS, Comstock BA, Baldwin E, de Andrade M, Kullo IJ, Tromp G, Kuivaniemi H, Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E, Kho A, Pacheco J, Hayes MG, Ritchie MD, Verma SS, Armstrong G, Stallings S, Denny JC, Carroll RJ, Crawford DC, Crane PK, Mukherjee S, Bottinger E, Manolio T, Li R, Keating B, Mirel DB, Carlson CS, Harley JB, Larson EB, Jarvik GP.  Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes and Immunity 16(1):1-7, Jan. 2015 (Epub Oct. 9, 2014). PMID: 25297839
  68. Almoguera B, He S, Corton M, Fernandez-San Jose P, Blanco-Kelly F, López-Molina M, García-Sandoval B, Del Val J, Guo Y, Tian L, Liu X, Guan L, Torres RJ, Puig JG, Hakonarson H, Xu X, Keating B, Ayuso C.  Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy. Orphanetics Journal of Rare Diseases Epub 9(1):190, Dec. 10, 2014. PMID: 25491489
  69. Guo Y, Menezes MJ, Menezes MP, Liang J, Li D, Riley LG, Clarke NF, Andrews PI, Tian L, Webster R, Wang F, Liu X, Shen Y, Thorburn DR, Keating BJ, Engel A, Hakonarson H, Christodoulou J, Xu X.  Delayed diagnosis of congenital myasthenia due to associated mitochondrial enzyme defect.  Neuromuscular Disorders 25(3):257-261, Mar. 2015 (Epub Dec. 10, 2014). PMID: 25557462
  70. Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to dyslipidemia and risk of preeclampsia.  American Journal of Hypertension 28(7):915-923, July 2015 (Epub Dec 17, 2014). PMID: 25523295
  71. Fischer ME, Schubert CR, Nondahl DM, Dalton DS, Huang G, Keating BJ, Klein BE, Klein R, Tweed TS, Cruickshanks KJ. Subclinical atherosclerosis and increased risk of hearing impairment. Atherosclerosis 238(2):344-349, Feb. 2015 (Epub Dec. 20, 2014). PMID: 25555266
  72. Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J. Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure, and lactic acidemia.  Human Molecular Genetics 24(8):2297-2307, Apr. 15, 2015 (Epub Jan. 2, 2015). PMID: 25556185
  73. Gil-Rodríguez MC, Deardorff MA, Ansari M, Tan CA, Parenti I, Baquero-Montoya C, Ousager LB, Puisac B, Hernández-Marcos M, Teresa-Rodrigo ME, Marcos-Alcalde I, Wesselink JJ, Lusa-Bernal S, Bijlsma EK, Braunholz D, Bueno-Martinez I, Clark D, Cooper NS, Curry CJ, Fisher R, Fryer A, Ganesh J, Gervasini C, Gillessen-Kaesbach G, Guo Y, Hakonarson H, Hopkin RJ, Kaur M, Keating BJ, Kibaek M, Kinning E, Kleefstra T, Kline AD, Kuchinskaya E, Larizza L, Li YR, Liu X, Mariani M, Picker JD, Pié Á, Pozojevic J, Queralt E, Richer J, Roeder E, Sinha A, Scott RH, So J, Wusik KA, Wilson L, Zhang J, Gómez-Puertas P, Casale CH, Ström L, Selicorni A, Ramos FJ, Jackson LG, Krantz ID, Das S, Hennekam RC, Kaiser FJ, FitzPatrick DR, Pié J.  De novo Heterozygous Mutations in SMC3 Cause a Range of Cornelia De Lange Syndrome-Overlapping Phenotypes.  Human Mutation 36(4):454-462, Apr. 2015 (Epub Mar. 17, 2015). PMID: 25655089
  74. Zhang J, Barbaro P, Guo Y, Alodaib A, Li J, Gold W, Adès L, Keating BJ, Xu X, Teo J, Hakonarson H, Christodoulou J.  Utility of next-generation sequencing technologies for the efficient genetic resolution of haematological disorders.  Clinical Genetics (Epub Feb. 20, 2015).  PMID: 25703294
  75. Tang W, Cushman M, Green D, Rich SS, Lange LA, Yang Q, Tracy RP, Tofler GH, Basu S, Wilson JG, Keating BJ, Weng LC, Taylor HA, Jacobs DR Jr, Delaney JA, Palmer CD, Young T, Pankow JS, O'Donnell CJ, Smith NL, Reiner AP, Folsom AR.  Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.  American Journal of Hematology 90(6):534-540, June 2015 (Epub Apr. 1, 2015). PMID: 25779970
  76. Keating BJ.  Advances in risk prediction of type 2 diabetes: integrating genetic scores with Framingham risk models.  Diabetes 64(5):1495-1497, May 2015.  PMID: 25908872
  77. Rodriguez S, Gaunt TR, Guo Y, Zheng J, Barnes MR, Tang W, Danish F, Johnson A, Castillo BA, Li YR, Hakonarson H, Buxbaum SG, Palmer T, Tsai MY, Lange LA, Ebrahim S, Davey Smith G, Lawlor DA, Folsom AR, Hoogeveen R, Reiner A, Keating B, Day IN.  Lipids, obesity and gallbladder disease in women: Insights from genetic studies using the cardiovascular gene-centric 50K SNP array.  European Journal of Human Genetics (Epub Apr. 29, 2015). PMID: 25920552
  78. Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, Goel A, Padmanabhan S, Asselbergs FW; EPIC-Netherland Investigators, Verschuren WM, Wijmenga C, Van der Schouw YT, Onland-Moret NC, Lange LA, Hovingh GK, Sivapalaratnam S, Morris RW, Whincup PH, Wannamethe GS, Gaunt TR, Ebrahim S, Steel L, Nair N, Reiner AP, Kooperberg C, Wilson JF, Bolton JL, McLachlan S, Price JF, Strachan MW, Robertson CM, Kleber ME, Delgado G, März W, Melander O, Dominiczak AF, Farrall M, Watkins H, Leusink M, Maitland-van der Zee AH, de Groot MC, Dudbridge F, Hingorani A, Ben-Shlomo Y, Lawlor DA; UCLEB Investigators, Amuzu A, Caufield M, Cavadino A, Cooper J, Davies TL; IN Day, Drenos F, Engmann J, Finan C, Giambartolomei C, Hardy R, Humphries SE, Hypponen E, Kivimaki M, Kuh D, Kumari M, Ong K, Plagnol V, Power C, Richards M, Shah S, Shah T, Sofat R, Talmud PJ, Wareham N, Warren H, Whittaker JC, Wong A, Zabaneh D, Davey Smith G, Wells JC, Leon DA, Holmes MV, Casas JP. Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.  International Journal of Epidemiology (Epub May 15, 2015). PMID: 25979724
  79. Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK.  Genetic risk score for essential hypertension and risk of preeclampsia.  American Journal of Hypertension (Epub May 23, 2015). PMID: 26002928
  80. Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, Guo Y, Tragante V, North KE, Cushman M, Asselbergs FW, Wilson JG, Lange LA, Drenos F, Reiner AP, Barnes MR, Keating BJ.  Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration.  Journal of Lipid Research 56(9):1781-1786, Sept. 2015 (Epub July 21, 2015). PMID: 26199122
  81. Wolf JH, Holmes MV, Fouraschen S, Keating BJ, Baker T, Emond J, Rader DJ, Shaked A, Olthoff KM.  Serum lipid expression correlates with function and regeneration following living donor liver transplantation.  Liver Transplant (Epub July 22, 2015). PMID: 26202132
  82. Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H.  Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.  Nature Medicine 21(9):1018-1027, Sept. 2015 (Epub Aug. 24, 2015). PMID: 26301688
  83. Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.   Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.  Genome Medicine 7(1):90, Oct. 1, 2015. PMID: 26423053
 
Publications
Reviews in Peer Reviewed Research Publications
  1. Staines-Urias E, Paez MC, Doyle P, Dudbridge F, Serrano NC, Ioannidis JP, Keating BJ, Hingorani AD, Casas JP.  Genetic association studies in pre-eclampsia: Systematic meta-analyses and field synopsis. [Review] International Journal of Epidemiology 41(6):1764-1775, Dec. 2012.
  2. Li YR, Levine JE, Hakonarson H, Keating BJ†. Making the genomic leap in HCT: Application of second-generation sequencing to clinical advances in hematopoietic cell transplantation. [Review] European Journal of Human Genetics 22(6):715-723, June 2014 (Epub Nov. 20, 2013).   († corresponding author). PMID: 24253860
  3. Almoguera B, Shaked A, Keating BJ.  Transplantation genetics: current status and prospects.  American Journal of Transplantation 14(4):764-778, Apr. 2014 (Epub Mar. 11, 2014.)  PMID: 24618335
  4. 4.   Li YR, Keating BJ. Transethnic genome-wide association studies: advantages and challenges of mapping in diverse populations. [Review] Genome Medicine 6(10):91, Oct. 31, 2014. PMID: 25473427
Contributions to Peer-Reviewed Clinical Research Publications, Participation Cited but not by Authorship
  1. Jarvik GP, Amendola LM, Berg JS, Brothers K, Clayton EW, Chung W, Evans BJ, Evans JP, Fullerton SM, Gallego CJ, Garrison NA, Gray SW, Holm IA, Kullo IJ, Lehmann LS, McCarty C, Prows CA, Rehm HL, Sharp RR, Salama J, Sanderson S, Van Driest SL, Williams MS, Wolf SM, Wolf WA; eMERGE Act-ROR Committee and CERC Committee; CSER Act-ROR Working Group, Burke W. Return of genomic results to research participants: The floor, the ceiling, and the choices in between.  American Journal of Human Genetics 94(6):818-826, June 5, 2014.  PMID: 24814192 (Dr. Keating is a member of the working group.)
Research Publications, Non-Peer Reviewed
  1. Keating BJ.  Investigation of genetic variation in the TNF locus with mitogen induced phenotypes in lymphoblastoid cell lines. Dissertation for Doctorate in Philosophy, University of Oxford Library, 2006.
Editorials, Chapters, Case Reports & Participation in Committee Reports
  1. Keating BJ, Knight JC.  Polymorphisms of TNF genes & disease susceptibility.  Nature Encyclopedia of Life Sciences. New York: Wiley On-line Library, 2006 (accessible at http://www.els.net/WileyCDA/ElsArticle/refId-a0002186.html ).
Alternative Media
  1. Keating BJ.  New genetic alterations associated with human height identified.  ScienceDaily Jan. 1, 2011 http://www.sciencedaily.com/releases/2010/12/101230123552.htm.
  2. Keating BJ.  Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups.  ScienceDaily Feb 9, 2012 http://www.sciencedaily.com/releases/2012/02/120209135054.htm.
  3. Keating BJ.  Twenty-one genes tied to cholesterol levels identified.  ScienceDaily Oct. 11, 2012 http://www.sciencedaily.com/releases/2012/10/121011123959.htm.
  4. Keating BJ.  Team uses 'meta-meta-analysis' of cardiochip data to id 21 genes linked to cholesterol levels.   Genomeweb Oct. 16, 2012 www.genomeweb.com/arrays/team-uses-meta-meta-analysis-cardiochip-data-id-21-genes-linked-cholesterol-level.
  5. Keating BJ.  CardioChip used to discover cholesterol genes.  The Philadelphia Inquirer Nov. 2012.
  6. Keating BJ.  Eleven new genes affecting blood pressure discovered.  ScienceDaily Feb 20, 2014 http://www.sciencedaily.com/releases/2014/02/140220141802.htm.
  7. Keating BJ.  Meta-analysis reveals new blood pressure loci.  Genomeweb Feb. 20, 2014 www.genomeweb.com/arrays/meta-analysis-reveals-new-blood-pressure-loci.
  8. Keating BJ.  More genetic signals found linking weight, heart health risk factors.  ScienceDaily Mar. 4, 2014 www.sciencedaily.com/releases/2014/03/140304141844.htm.
  9. Keating BJ.  Gene chip may help prevent heart disease.  Medical News Today Mar. 18, 2012 http://www.medicalnewstoday.com/articles/243046.php.
Patents
  1. Keating BJ.  The use of micro-ribonucleic acid (miRNA) signatures to diagnose subclinical transplant rejection.  Patent filed 2013.
  2. Keating BJ.  The use of miRNA signatures to diagnose tolerance of immunosuppression therapy in transplantation.  Patent filed 2014.
  3. Keating BJ.  Shared drug targets for therapeutics from large scale autoimmune GWAS in pediatric populations.  Patent filed 2014.
 
Awards
2012  National finalist, Faculty Mentor of the Year section (post-doctoral mentor level)
National PostDoctoral Association
 
 
 
 
 
 

                          

 

Brendan Keating

 
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