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Pablo Laje, M.D.
Pediatric Surgery

 
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Administrative Office:
Children’s Hospital of Philadelphia
The Division of Pediatric General and
Thoracic Surgery
34th Street and Civic Center Boulevard
5th Floor Wood Pavilion
Philadelphia, PA 19104
Administrative Assistants: Ashley Anastasi
Administrative Telephone: 215-590-5905
Administrative Fax: 215-386-4036
Patient Appointments: 215-590-2727

laje@email.chop.edu

Link to Children's Hospital of Philadelphia

 

Dr Pablo Laje is an Assistant Professor of Surgery and Attending Surgeon at The Children's Hospital of Philadelphia. He completed his training in Pediatric Surgery in Argentina and came to CHOP in 2005 to do research and to obtain further training in the areas of minimally invasive surgery and fetal surgery. He has published numerous articles and book chapters on these two areas. His clinical practice involves all aspects of pediatric surgery.

 
Faculty Appointments
2011 - present Assistant Professor of Clinical Surgery
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
 
 
 
 
 
 
 
 
Education/Training
1993 - 1999 University of Buenos Aires Medical School
Argentina
 
1987 - 1992 National College No. 4
Buenos Aires, Argentina
 
Postgraduate Training and Fellowship Appointments
2005 - 2011 Pediatric / Fetal Surgery Fellowship
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2001 - 2005 Pediatric Surgery Fellowship
National Pediatric Hospital "J.P. Garrahan"
Buenos Aires, Argentina
 
2000 - 2001 General Surgery Internship
"J.A. Fernández" General Hospital
Buenos Aires, Argentina
 
Memberships/Societies
 
Scientific Committees
2005 - present International Pediatric Endosurgery Group
 
 
 
 
 
 
 
Research
 2008 - 2010

International Pediatric Endosurgery Group – Basic Research Grant: “The impact of pneumoperitoneum on livers with biliary atresia: an oxidative stress study”.

 
 
 
 
 
 
 
 
 
Publications
Research Publications, Peer Reviewed
  1. M-Ferro M, Duarte S, Laje P. Single port thoracoscopy for the treatment of pleural empyema in children. Journal of Pediatric Surgery 39(8):1194-1196, Aug. 2004.
  2. M-Ferro M, Elmo G, Laje P. Laparoscopic pocket splenopexy for wandering spleen: A case report. Journal of Pediatric Surgery 40(5):882-884, May 2005.
  3. M-Ferro M, Piaggio L, Laje P. Combined thoraco-laparoscopy for trans-diaphragmatic thor-acoabdominal enteric duplications. Journal of Pediatric Surgery 40(9):e37–40, Sept. 2005.
  4. M-Ferro M, Esteves E, Laje P. Laparoscopic treatment of biliary atresia and choledochal cyst.” Seminars in Pediatric Surgery 14(4):206-215, Nov. 2005.
  5. M-Ferro M, Rubio M, Piaggio M, Laje P. Thoracoscopic approach for congenital esophageal stenosis. Journal of Pediatric Surgery 41(10): e5-7, Oct. 2006.
  6. Laje P, M-Ferro M. Thoracoscopic double aortic arch division with harmonic scalpel: A case report. Journal of Thoracic & Cardiovascular Surgery 133(3):819-820, Mar. 2007.
  7. Laje P, Bailez MM, Questa H. Laparoscopic “leak-free” technique for the treatment of choledochal cysts. Journal of Laparoendoscopic and Advanced Surgical Techniques 17(4):519-521, Aug. 2007.
  8. Laje P, Peranteau WH, Flake AW. Repair of indirect inguinal hernias by laparoscopic “joining of the edges.” Surgical Laparoscopy Endoscopy & Percutaneous Techniques 18(3):280-282, Aug. 2008.
  9. Laje P, Liechty KW. Survival in primary congenital pulmonary lymphangiectasia with hydrops fetalis. Fetal Diagnosis & Therapy 24(3):225-229, 2008.
  10. Laje P, Shang D, Cao W, Niiya M, Endo M, Radu A, DeRogatis N, Scheiflinger F, Zoltick PW, Flake AW, Zheng XL. Correction of murine Adamts13 deficiency by hematopoietic progenitor cell-mediated gene therapy. Blood 113(10):2172-2180, Mar. 5, 2009.
  11. Laje P, Mattei PA. Laparoscopic adrenalectomy for adrenal tumors in children. Journal of Laparoendoscopic and Advanced Surgical Techniques 19(Suppl 1):S27-29, Apr. 2009.
  12. Merianos DJ, Tiblad E, Santore MT, Todorow CA, Laje P, Endo M, Zoltick PW, Flake AW. Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice. Journal of Clinical Investigation 119(9):2590-2600, Sept. 2009.
  13. Tamburri N, Laje P, Boglione M, Martinez-Ferro M. Extrathoracic esophageal elongation (Kimura's technique): A feasible option for the treatment of patients with complex esophageal atresia. Journal of Pediatric Surgery 44(12):2420-2425, Dec. 2009.
  14. Laje P, Halaby L, Adzick NS, Stanley CA. Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. Pediatric Diabetes 11(2):142-147, Mar. 2010.
  15. Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol. Gene Therapy 17(3):412-418, Mar. 2010.
  16. Laje P, Clark FH, Friedman JR, Flake AW. Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. Journal of Pediatric Surgery 45(9):1791-1796, Sept. 2010.
  17. Laje P, Stanley CA, Adzick NS. Intussusception after pancreatic surgery in children: A case series. Journal of Pediatric Surgery 45(7):1496-1499, July 2010.
  18. Laje P, Flake AW, Adzick NS. Prenatal diagnosis and postnatal resection of intra-abdominal enteric duplications. Journal of Pediatric Surgery 45(7):1554-1558, July 2010.
  19. t Peter SD, Valusek PA, Hill S, Wulkan ML, Shah SS, Ferro MM, Laje P, et al:  “Laparoscopic adrenalectomy in children: a multicenter experience” J Laparoendosc Adv Surg Tech A 21(7):647-9, 2011.
  20. Laje P, Stanley CA, Palladino AA, Becker SA, Adzick NS: “Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism. J Pediatr Surg 47(1):130-5, 2012.
  21. Laje P, Johnson MP, Howell LJ, Hedrick, HL, Flake AW, Adzick NS: “Ex Utero Intrapartum Treatment (EXIT) in the Management of Giant Cervical Teratomas” J Ped Surg 47(6):1208-16, 2012
  22. Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol 891:169-81, 2012.
  23. Dingemann J, Laje P, St Peter SD, Ure BM. IPEG Survey on Live Case Demonstrations in Pediatric Surgery. J Laparoendosc Adv Surg Tech 22(7):705-9, 2012.
  24. Laje P, States LJ, Zhuang H, Becker SA, Palladino AA, Stanley CA, Adzick NS. Accuracy of PET/CT Scan in the Diagnosis of the Focal Form of Congenital Hyperinsulinism. Presented at the 59th Meeting of the British Association of Pediatric Surgeons, Rome, 2012. J Ped Surg 48(2):388-93, 2013.
  25. Muchantef K, Epelman M, Darge K, Kirpalani H, Laje P, Anupindi SA. Sonographic and radiographic imaging features of the neonate with necrotizing enterocolitis: correlating findings with outcomes. Pediatr Radiol. 2013 Jun 15. [Epub ahead of print]
  26. Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Perinatal management of congenital oropharyngeal tumors: The ex utero intrapartum treatment (EXIT) approach. J Pediatr Surg 48(10):2005-2010, 2013.
  27. Laje P, Bhatti TR, Adzick NS. Solid pseudopapillary neoplasm of the pancreas in children: A 15-year experience and the identification of a unique immunohistochemical marker. J Pediatr Surg 48(10):2054-2060, 2013.
  28. Laje P, Fenton SJ, Peranteau WH. “Total colonic Hirschsprung’s disease and anorectal malformation in a baby with Pallister Hall syndrome” J Ped Surg CR 1(9), 308-310, 2013.
  29. Laje P,  Palladino AA,  Bhatti TR, States LJ,  Stanley CA,  Adzick NS. “Pancreatic surgery in infants with Beckwith–Wiedemann and Hyperinsulinism” J Pediatr Surg 48(12):2511-6, 2013.
  30. Laje P, Adzick, NS. “Modified Puestow procedure for the management of chronic pancreatitis in children” J Pediatr Surg 48(11):2271-5, 2013.
Reviews in Peer Reviewed Research Publications
  1. Laje P, M-Ferro M, Grisoni E, Dudgeon D. Intra-abdominal pulmonary sequestration: A case series and review of the literature. [Review] Journal of Pediatric Surgery 41(7): 1309-1312, July 2006.
  2. Laje P, Liechty KW. Post-natal management and outcome of prenatally diagnosed lung lesions. [Review] Prenatal Diagnosis 28(7):612-618, July 2008.
Abstracts
  1. Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol. Presented at the 10th American Society of Gene Therapy meeting, Seattle, WA.
  2. Laje P, Mattei PA. Laparoscopic adrenalectomy for adrenal tumors in children. Presented at the 17th IPEG meeting, Paris, France, 2008.
  3. Laje P, Clark FH, Friedman JR, Flake AW. Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. Presented at the 17th IPEG meeting, Paris, France, 2008.
  4. Laje P, Shang D, Cao W, Niiya M, Endo M, Radu A, DeRogatis N, Scheiflinger F, Zoltick PW, Flake AW, Zheng XL. Correction of murine Adamts13 deficiency by hematopoietic progenitor cell-mediated gene therapy. Presented at the 50th American Society of Hematology meeting, San Francisco, CA, 2008.
Editorials, Chapters & Participation in Committee Reports
  1. Laje P, Martinez-Ferro M: “Acute Abdomen” in Sinha CK and Davenport M (eds.): Handbook of pediatric surgery, Springer Publishing, 173-176, 2010.
  2. Laje P, Nichol P: “Laparoscopic and open small bowel resection” in Chen H, (ed.): Illustrative Handbook of General Surgery, Springer Publishing, 127-133, 2010.
  3. Laje P: “Foregut duplications” in Mattei P (ed.): Fundamentals of Pediatric Surgery, Springer Publishing, 267 - 271, 2010.
  4. Laje P, Adzick NS: “Pancreatic Neoplasms in Children” in Grosfeld JA (ed.): The Surgery of Childhood Tumors (Third edition) - Springer Publishing – In Press.
  5. Laje P, Adzick NS: “Surgery for Congenital Hyperinsulinism” in Losty P (ed.): Rickham's Neonatal Surgery – Springer London - In Press.
  6. Laje P, Adzick NS: “Congenital Hyperinsulinism and Surgery” in Davenport M,  Heaton N, Superina R (eds.): Surgery of the Liver, Bile Ducts and Pancreas in Children (Third edition) – Taylor and Francis Publishing Group – In Press.
 
Awards
 
 
 
 
 
 
 
 
 

Dr. Pablo Laje

 
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