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William H. Peranteau, M.D.
Pediatric Surgery

 
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Administrative/Clinical Offices:
Children's Hospital of Philadelphia
Pediatric General, Thoracic and Fetal Surgery
34th Street & Civic Center Boulevard
5th Floor, Wood Center
Philadelphia, PA 19104
Administrative Assistant: Colleen Corcoran
Telephone: 215-590-2742
Fax: 215-590-4875

peranteauw@email.chop.edu

 

 

 
Faculty Appointments
2010 - 2012 Instructor  of Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
08/01/12 - present Assistant Professor of Surgery, Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
Hospital and/or Administrative Appointments
08/01/12 - present Active Physician, Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
08/01/12 - present Attending Physician, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
08/01/12 - present Attending Physician, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
Education/Training
1997 BA, Princeton University
Princeton, New Jersey (molecular biology)
 
2002 MD, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Postgraduate Training and Fellowship Appointments
2002 - 2003 Intern in General Surgery, Brigham & Women's Hospital
Boston, Massachusetts
   
2003 - 2010 Resident in General Surgery, Brigham & Women's Hospital
Boston, Massachusetts
   
2004 - 2007 Research Fellow in Surgery, Children's Institute for Surgical Science
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
   
2010 - 2012 Fellow in Pediatric Surgery, The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
Memberships/Societies
 
Professional and Scientific Societies
2008 - present American College of Surgeons
 
 
 
 
 
 
 
Research
 
 
 
 
 
 
 
 
 
 
Publications
 
Research Publications, peer reviewed (print or other media)
  1. Hayashi S, Peranteau WH, Shaaban AF, Flake AW: Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell trans- plantation and postnatal donor lymphocyte infusion. Blood 100(3): 804-812, Aug. 2002.
  2. Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW: High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation. Blood 100(6): 2225-2234, Sept. 2002.
  3. Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T, Flake AW: Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Experimental Hematology 31(2): 176-184, Feb. 2003.
  4. Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW: Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice. Journal of Gene Medicine 5(11): 941-950, Nov. 2003.
  5. Hayashi S, Hsieh M, Peranteau WH, Ashizuka S, Flake AW: Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes. Experimental Hematology 32(3): 290-299, Mar. 2004.
  6. Ashizuka S, Peranteau WH, Hayashi S, Flake AW: Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation. Experimental Hematology 34(3): 359-368, Mar. 2006.
  7. Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW: CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 108(13): 4268-4274, Dec. 2006.
  8. Peranteau WH, Bathaii SM, Pawel B, Hardy O, Alavi A, Stanley CA, Adzick NS: Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism. Journal of Pediatric Surgery 42(1): 188-192, Jan. 2007.
  9. Peranteau WH, Endo M, Adibe OO, Flake AW: Evidence for an immune barrier after in utero hematopoietic-cell transplantation. Blood 109(3): 1331-1333, Feb. 2007.
  10. Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu Y, Flake AW, High KA: Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Molecular Therapy: The Journal of the American Society of Gene Therapy 15(9): 1677-1685, Sept. 2007.
  11. Peranteau WH, Wilson RD, Liechty KW, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS: Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survival. Fetal Diagnosis and Therapy 22(5): 365-371, 2007.
  12. Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW: Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Molecular Therapy: The Journal of the American Society of Gene Therapy 16(1): 131-7, Jan. 2008.
  13. Badillo AT, Peranteau WH, Heaton TE, Quinn C, Flake AW: Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. British Journal of Haematology 141(2): 224-34, Apr. 2008.
  14. Badillo AT, Peranteau WH, Heaton TE, Quinn C, Flake AW: Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. British Journal of Haematology 141(2): 224-34, Apr. 2008.
  15. Laje P, Peranteau WH, Flake AW: Repair of indirect inguinal hernias by "laparoscopic joining of the edges". Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 18(3):280-282, June 2008.
  16. Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW: IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. Journal of Investigative Dermatology 128(7): 1852-60, July 2008.
  17. Peranteau WH, Merchant AM, Hedrick HL, Liechty KW, Howell LJ, Flake AW, Wilson RD, Johnson MP, Bebbington MW, Adzick NS: Prenatal course and postnatal management of peripheral bronchial atresia: Association with congenital cystic adenomatoid malformation of the lung. Fetal Diagnosis and Therapy 24(3): 190-6, 2008.
  18. Peranteau WH, Heaton TE, Gu Y, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW: Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation 15(3): 293-305, Mar. 2009.
  19. Endo M, Henriques-Coelho T, Zoltick P W, Stitelman D H, Peranteau W H, Radu A, Flake A W: The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors. Gene Therapy 17(1): 61-71, Jan. 2010.
  20. Peranteau WH, Havens JM, Harrington S, Gates JD: Re-establishing surgical care at Port-au-Prince General Hospital, Haiti. Journal of the American College of Surgeons 211(1): 126-30, July 2010.
Research Publications, peer-reviewed reviews
  1. Peranteau WH, Hayashi S, Kim HB, Shaaban AF, Flake AW: In utero hematopoietic cell transplantation: what are the important questions? Fetal Diagnosis and Therapy 19(1): 9-12, Jan./Feb. 2004.
Abstracts (Last 3 years)
  1. Osterhoudt KC, Peranteau W, Shaw K, Flake A. Dangerous attraction: A 2-year-old girl with enteric and mesenteric fistulae after ingestion of spherical magnetic toys.  Clinical Toxicology 49:548, 2011.
Editorials, Chapters, Case Reports & Participation in Committee Reports
  1. Karlawish JHT, Peranteau WH: Genetic screening in general internal medicine. Genetics in the Clinic: Clinical, Ethical & Social Implications for Primary Care. Mahowald MB, Aspinwall T, McKusick VA, Scheuerle A (eds.). Philadelphia: Mosby, Page: 181-187, 2001.
  2. Peranteau WH, Ganguly A, Steinmuller L, Thornton P, Johnson MP, Howell LJ, Stanley CA, Adzick NS: Prenatal diagnosis and postnatal management of diffuse congenital hyperin- sulinism: a case report. [Case Report] Fetal Diagnosis and Therapy 21(6): 515-518, 2006.
  3. Merchant AM, Peranteau W, Wilson RD, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick NS: Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation. [Case Report] Fetal Diagnosis and Therapy 22(6): 435-439, 2007.

Dr. William Peranteau

 
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