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William H. Peranteau, M.D.
Pediatric Surgery

 
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Administrative/Clinical Offices:
Children's Hospital of Philadelphia
Pediatric General, Thoracic and Fetal Surgery
34th Street & Civic Center Boulevard
5th Floor, Wood Center
Philadelphia, PA 19104
Administrative Assistant: Colleen Corcoran
Telephone: 215-590-2742
Fax: 215-590-4875

peranteauw@email.chop.edu

Link to Children's Hospital of Philadelphia

 

Dr. Peranteau is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at The Children’s Hospital of Philadelphia and an assistant professor of surgery at the Perelman School of Medicine at the University of Pennsylvania.

His areas of interest include fetal biology, fetal and neonatal surgery, and general pediatric surgery. Dr. Peranteau earned his bachelor’s degree in molecular biology from Princeton University, and his medical degree from the University of Pennsylvania.

Prior to joining the Center team in 2012, Dr. Peranteau completed his residency in general surgery at Brigham and Women’s Hospital, Boston, Mass., and a fellowship in pediatric general surgery at CHOP. He also served as a research fellow with CHOP’s Center for Fetal Research for four years, investigating the role of in utero bone marrow and stem cell transplantation for the management of congenital hematologic disorders such as sickle cell disease.

Dr. Peranteau has published articles in the Journal of the American College of Surgeons, the Journal of Pediatric Surgery, Fetal Diagnosis and Therapy, Experimental Hematology and Blood. He is board certified in general surgery.

 
Faculty Appointments
2012 - present Assistant Professor of Surgery, Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
2010 - 2012 Instructor  of Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Hospital and/or Administrative Appointments
2012 - present Active Physician, Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2012 - present Attending Physician, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2012 - present Attending Physician, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
Education/Training
2002 MD, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1997 BA, Princeton University
Princeton, New Jersey (molecular biology)
 
Postgraduate Training and Fellowship Appointments
2010 - 2012 Fellow in Pediatric Surgery, The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2004 - 2007 Research Fellow in Surgery, Children's Institute for Surgical Science
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2003 - 2010 Resident in General Surgery, Brigham & Women's Hospital
Boston, Massachusetts
 
2002 - 2003 Intern in General Surgery, Brigham & Women's Hospital
Boston, Massachusetts
 
Memberships/Societies
2008 - present American College of Surgeons
Resident Member (2008-2012)
Associate Member (2012-present)
 
1997 - present Phi Beta Kappa, Academic Honor Society, Member
 
1997 - present Sigma Xi, Scientific Honor Society, Member
 
 
 
 
Research
2004 - 2007 The Children's Hospital of Philadelphia, Department of Surgery
Advisor: Dr. Alan Flake
T32 Ruth L. Kirschstein NRSA Trainee
I had the privilege of working in Dr. Flake’s lab for 3 years in the middle of my surgical residency during which I continued evaluating in utero hematopoietic cell transplantation (IUHCT) in the murine model and initiated a preclinical canine model of IUHCT into which we translated some of our findings from the murine model. In the murine model, we demonstrated, against previously held beliefs, the presence of an immune barrier to allogeneic IUHCT and attempted to overcome one of the main limitations to the clinical application of IUHCT by increasing both the efficiency and level of engraftment via inhibition of the CD26 peptidase on the donor cells. A canine model of IUHCT was thought necessary prior to the broad clinical application of IUHCT. In this model we demonstrated the ability to achieve stable low level haploidentical engraftment and to provide a platform to increase
engraftment to clinically significant levels by postnatal nonmyeloablative transplants in recipients of IUHCT. Finally, we demonstrated the ability to treat and reverse the lethality of the canine leukocyte adhesion deficiency disease, a large animal model very similar to the human leukocyte adhesion deficiency disease, by IUHCT alone.
 
2000 - 2001 The Children’s Hospital of Philadelphia, Department of Surgery
Advisor: Dr. Alan Flake
Howard Hughes Medical Institute Research Training Fellow
Transplantation into a fetal recipient allows one to take advantage of normal developmental ontogeny with the goal of performing the transplant prior to the maturation of the immune system and the onset of the target disease. Initial studies demonstrated that it was possible to transplant allogeneic bone marrow in utero and that successful engraftment resulted in donor specific tolerance. Building on these studies, we evaluated mechanisms of increasing allogeneic engraftment to potentially clinically significant levels in tolerant chimeric mice that had been created by in utero hematopoietic cell transplantation (IUHCT). We studied two postnatal mechanisms of increasing donor cell engraftment following IUHCT: low dose nonmyeloablative irradiation followed by a “booster” transplant and donor
lymphocyte infusion. Using both mechanisms, we were able to achieve near complete stable donor cell chimerism in tolerant mice. These techniques were then applied to a model of murine hemoglobinopathies and were shown to correct the disease.
 
1998 - 1998 University of Pennsylvania, Department of Immunology
Advisor: Dr. Yvonne Patterson
I had the privilege of working in the laboratory of Dr. Patterson during the summer between my first and second years of medical school. This experience provided me the opportunity to study the immune response to vaccines in the murine model. Specifically, I studied the murine immune response to a Listeria based HIV vaccine and demonstrated that oral administration of this vaccine elicited a Th1 immune response.
 
1996 - 1997 Princeton University, Department of Immunology
Advisor: Dr. Albert Bendelac
I developed computer based molecular models of CD1.1, an MHC class I-like molecule, and the interaction of CD1.1 with the limited T cell receptors which are specific for it. Based on these computer models, we performed site directed mutagenesis of a site hypothesized to play a role in CD1.1 expression and its interaction with a TCR. We demonstrated by flow cytometry that the mutation decreased the cell surface expression of CD1.1. This experience contributed to my senior thesis research project in the Department of Molecular Biology at Princeton University.
 
June 1995 -
August 1995
Coriell Institute for Medical Research, New Jersey, Department of Cell and Molecular Biology
Advisor: Dr. Jeanne Beck
During the summer between my sophomore and junior years in college I was fortunate to have had the opportunity to work at the Coriell Institute where I performed research technician related activities and learned many basic molecular biology techniques. Specifically, I studied Primer Extension Preamplification, a PCR based technique,
and its applicability to the study of the molecular genetics of breast cancer. This summer provided me my first true basic science research experience and ignited my interest in research and its role in Medicine.
 
Publications
Original Articles
  1. Hayashi S, Peranteau WH, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism
    achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood. 2002;100(3):804-12.
  2. Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation. Blood.
    2002;100(6):2225-34.
  3. Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T,
    Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models
    of hemoglobinopathy. Exp Hematol. 2003;31(2):176-84.
  4. Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW. Long-term
    transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adenoassociated viral vectors in mice. J Gene Med. 2003;5(11):941-50.
  5. Peranteau WH, Hayashi S, Kim HB, Shaaban AF, Flake AW. In utero hematopoietic cell transplantation: what are the important questions? Fetal Diagn Ther. 2004;19(1):9-12.
  6. Hayashi S, Hsieh M, Peranteau WH, Ashizuka S, Flake AW. Complete allogeneic hematopoietic
    chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes. Exp Hematol. 2004;32(3):290-9.
  7. Peranteau WH, Flake AW. In-utero tolerance. Current Opinion Organ Transplant. 2006;11:353-359.
  8. Peranteau WH, Ganguly A, Steinmuller L, Thornton P, Johnson MP, Howell LJ, Stanley CA, Adzick NS.
    Prenatal diagnosis and postnatal management of diffuse congenital hyperinsulinism: a case report. Fetal Diagn Ther. 2006;21(6):515-8.
  9. Ashizuka S, Peranteau WH, Hayashi S, Flake AW. Busulfan-conditioned bone marrow transplantation
    results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell
    transplantation. Exp Hematol. 2006;34(3):359-68.
  10. Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances
    allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood.
    2006;108(13):4268-74.
  11. Peranteau WH, Wilson RD, Liechty KW, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick
    NS. Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid
    malformation growth and fetal survival. Fetal Diagn Ther. 2007;22(5):365-71.
  12. Peranteau WH, Bathaii SM, Pawel B, Hardy O, Alavi A, Stanley CA, Adzick NS. Multiple ectopic lesions
    of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism. J Pediatr Surg. 2007;42(1):188-92.
  13. Merchant AM, Peranteau W, Wilson RD, Johnson MP, Bebbington MW, Hedrick HL, Flake AW, Adzick
    NS. Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation. Fetal Diagn Ther. 2007;22(6):435-9.
  14. Peranteau WH, Endo M, Adibe OO, Flake AW. Evidence for an immune barrier after in utero
    hematopoietic-cell transplantation. Blood. 2007;109(3):1331-3.
  15. Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA.
    Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1- F.IX in hemophilia B mice. Mol Ther. 2007;15(9):1677-85.
  16. Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW.
    Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral
    vector driven by the keratin 5 promoter. Mol Ther. 2008;16(1):131-7.
  17. Badillo AT*, Peranteau WH*, Heaton TE, Quinn C, Flake AW. Murine bone marrow derived stromal
    progenitor cells fail to prevent or treat acute graft-versus-host disease. Br J Haematol. 2008;141(2):224-34. *contributed equally to the manuscript
  18. Laje P, Peranteau WH, Flake AW. Repair of indirect inguinal hernias by "laparoscopic joining of the
    edges". Surg Laparosc Endosc Percutan Tech. 2008;18(3):280-2.
  19. Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW. IL-10 overexpression
    decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. J Invest Dermatol. 2008;128(7):1852-60.
  20. Peranteau WH, Merchant AM, Hedrick HL, Liechty KW, Howell LJ, Flake AW, Wilson RD, Johnson MP,
    Bebbington MW, Adzick NS. Prenatal Course and Postnatal Management of Peripheral Bronchial Atresia: Association with Congenital Cystic Adenomatoid Malformation of the Lung. Fetal Diagn Ther.
    2008;24(3):190-196.
  21. Peranteau WH, Heaton TE, Gu, YC, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP,
    Hickstein DD, Flake AW. Haploidentical in utero hematopoietic cell transplantation improves phenotype
    and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model. Biol Blood Marrow Transplant. 2009;15(3):293-305.
  22. Endo M, Henriques-Coelho T, Zoltick PW, Stitelman DH, Peranteau WH, Radu A, Flake AW. The
    developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors. Gene Ther. 2010;17(1):61-71.
  23. Peranteau WH, Havens JM, Harrington S, Gates JD. Reestablishing surgical care at Port au Prince General Hospital, Haiti. Journal of the American College of Surgeons. 2010;211(1):126-130.
  24. Osterhoudt KC, Peranteau WH, Shaw KN, Flake AW. A 2-year-old girl with abdominal pain after an
    action sure to attract attention. Pediatric Emergency Care. 2012;28(12):1406-1408.
    25. Laje P, Fenton SJ, Peranteau WH. Total colonic Hirschprung’s disease and anorectal malformation in a baby with Pallister-Hall syndrome. J Ped Surg Case Reports. 2013;1:308-310.
  25. Peranteau WH, Palladino AA, Bhatti TR, Becker SA, States LJ, Stanley CA, Adzick NS. The surgical
    management of insulnomas in children. J of Pediatr Surg. 2013;48(12):2517-2524.
  26. Partridge EA, Canning D, Long C, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Urologic and
    anorectal complications of sacrococcygeal teratomas: prenatal and postnatal predictors. J Pediatr Surg. 2014;49(1):139-143.
  27. Peranteau WH, Moldenhauer JS, Khalek N, Martinez-Poyer JL, Howell LJ, Johnson MP, Flake AW,
    Adzick NS, Hedrick HL. Open fetal surgery for central bronchial atresia. Fetal Diagn Ther. 2014;35:141-
    147.
  28. Jump C, Anupindi S, Peranteau W, Dunham B, Mamula P. Extensive thoracic injury from button battery
    ingestion. J Pediatr Gastroenterol. 2014 April 23 Epub ahead of print.
  29. Kovatis K, Zhang H, Peranteau W, Goldber DJ, Connelly J, Rintoul N. A case of Avalon cannula
    malposition and successful conversion to V-A Ecmo in a neonate. J Ped Surg Case Reports. 2014;2:225-227.
  30. Vrecenak JD, Pearson EG, Santore MT, Todorow CA, Li H, Radu A, Bhatti T, Peranteau WH, Johnson
    MP, Flake AW. Stable long-term hematopoietic chimerism achieved in a canine model of allogeneic in
    utero hematopoietic cell transplantation. Blood. 2014 May 28 Epub ahead of print.
  31. Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D'Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors
    associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014;49:890-894.
  32. Peranteau WH (2014) In utero hematopoietic cell transplantation: induction of donor specific immune
    tolerance and postnatal transplants. Front. Pharmacol. 5:251. doi: 10.3389/fphar.2014.00251
  33. Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Scott Adzick N, Hedrick
    HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014;49:1767-1770.
  34. Vrecenak JD, Howell LJ, Khalek N, Moldenhauer JS, Johnson MP, Coleman BG, Victoria T, Hedrick HL,
    Peranteau WH, Flake AW, Adzick NS. Outcomes of prenatally diagnosed lung lesions in multigestational
    pregnancies. Fetal Diagn Ther. 2014;36:312-319.
  35. Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL,
    Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal
    Myelomeningocele Repair: The Post-MOMS Experience at the Children’s Hospital of Philadelphia. Fetal
    Diagn Ther, 2014 Aug 15 [Epub ahead of print].
  36. Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero
    intrapartum treatment (EXIT) in the management of cervical lymphangioma. J Pediat Surg. 2104 in press
  37. Partridge EA, Herkert L, Hanna B, Rintoul, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. B-type
    natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal
    membrane oxygenation in congenital diaphragmatic hernia. J Pediat Surg. 2104 in press
  38. Peranteau WH, Adzick NS, Boelig MM, Flake AW, Hedrick HL, Moldenhauer JS, Khalek N, Martinez-
    Poyer J, Johnson MP. Thoracoamniotic shunts for the management of fetal lung lesions and pleural
    effusions: A review of 76 cases. J Pediat Surg. 2104 in press
Chapters
  1. Karlawish JHT, Peranteau WH. Genetic Screening in General Internal Medicine. In: Genetics in the Clinic: Clinical, Ethical, and Social Implications for Primary Care. St Louis (MO): Mosby; 2001. p. 181-187.
  2. Peranteau WH. Smink DS. Appendix, Meckel’s, and Other Small Bowel Diverticula. In: Maingot’s Abdominal Operations 12th Ed. New York (NY): McGraw Hill Medical; 2013
  3. Peranteau WH. Mattei PA. Hernias. In: Comprehensive Pediatric Hospital Medicine 2nd Ed. New York (NY): McGraw Hill Medical; 2014
  4. Peranteau WH. Mattei PA. Hirschprung’s Disease. In: Pediatric Gastrointestinal and Liver Disease 5th Ed. Philadelphia (PA): Elsevier Saunders; 2014
Abstracts
  1. Hayashi SH, Shaaban AF, Peranteau WH, Abdulmalik O, Chen Q, Asakura T, Flake AW. High level expression of donor hemoglobin and decrease in the level of membrane associated denatured hemoglobin (MADH) as an indicator of disease severity after in utero bone marrow transplantation in a murine model of β-thalassemia. Blood. 2000;96:174a.
  2. Shaaban AF, Milner R, Hayashi S, Peranteau W, Flake AW. Tolerance induction by in utero hematopoietic stem cell transplantation is required to facilitate higher levels of engraftment with post-natal booster transplants. Blood. 2000;96:306b.
  3. Hayashi S, Hsieh M, Peranteau W, Flake AW. Complete donor chimerism across full allogeneic barriers achieved by in utero hematopoietic stem cell transplantation and prenatal co-transplantation of LLME treated MHC sensitized donor lymphocytes. Blood. 2001;98:170a.
  4. Hayashi S, Peranteau W, Shaaban AF, Flake AW. Complete donor chimerism across full allogeneic barriers achieved by a combined strategy of in utero hematopoietic stem cell transplantation followed by postnatal donor lymphocyte infusion. Blood. 2001;98:383a.
  5. Peranteau WH, Hayashi S, Hsieh M, Shaaban AF, Flake AW. Conversion of minimal allogeneic chimerism to near complete chimerism in tolerant recipients after in utero hematopoietic stem cell transplantation by postnatal non-myeloablative total body irradiation followed by bone marrow transplantation. Blood. 2001;98:170a.
  6. Hayashi S, Peranteau W, Abdulmalik O, Chen Q, Horiuchi K, Asakura T, Flake AW. Correction of murine hemoglobinopathies across full MHC barriers by in utero hematopoietic stem cell transplantation followed by postnatal non-myeloablative BMT. Blood. 2001;98:170-171a.
  7. Peranteau WH, Hayashi S, Shaaban AF, Flake AW. Engraftment of enriched hematopoietic stem cells (HSC) in the tolerant, non-myeloablated allogeneic host: requirement for facilitation of engraftment despite lack of T cell mediated alloreactivity. Blood. 2001;98:170a.
  8. Hayashi S, Abdulmalik O, Peranteau W, Shaaban AF, Chen Q, Asakura T, Flake AW. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy: the selective advantage for donor erythropoiesis is enhanced by fetal liver donor source and shortened red cell half life. Blood. 2001;98:171a.
  9. Peranteau WH, Hayashi S, Ashizuka S, Hsieh M, Flake AW. Moderate enhancement of allogeneic chimerism following a postnatal cyclophosphamide (CP) based transplant regimen in recipients made tolerant by in utero hematopoietic stem cell transplantion (IUHSCTx). Blood. 2001;98:319b.
  10. Hayashi S, Abdulmalik O, Peranteau WH, Chen Q, Horiuchi K, Asakura T, Flake AW. Correction of murine β-thalassemia and sickle cell disease across full MHC barriers by in utero hematopoietic cell transplantation followed by postnatal donor lymphocyte infusion. Blood. 2003;102(11):3509a.
  11. Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick P, Flake AW. CD26 inhibition enhances allogeneic donor cell homing and engraftment after in utero bone marrow transplantation. Blood. 2005;106(11):1275.
  12. Peranteau WH, Badillo AT, Alcorn K, Filice S, Flake AW. Murine mesenchymal stem cells fail to suppress acute graft versus host disease. Blood. 2005;106(11):5253.
  13. Peranteau WH, Endo M, Adibe OO, Flake AW. Evidence for an Adaptive Immune Barrier after in Utero Hematopoietic Cell Transplantation. Blood. 2006;108(11):3179.
  14. Peranteau WH, Gu YC, Volk S, Tuschong L, Bauer TR, Badillo A, Kaye A, Johnson MP, Hickstein DD, Flake AW. In Utero Hematopoietic Cell Transplantation Using Haploidentical Parental Donors Reverses the Lethal Phenotype in Dogs with Canine Leukocyte Adhesion Deficiency. Blood. 2006;108(11):624.
  15. Laje P, Peranteau WH, Endo M, Zoltick PW, Flake AW. In Utero Transplantation of Transduced Hematopoietic Stem Cells Results in Deletion of Transgene-Specific T Cells. Blood. 2006;108(11):3266.
  16. Peranteau WH, Badillo AT, Hedrick HL, Flake AW, Adzick NS, Liechty KW. The role of mesenchymal regulatory genes in the pathogenesis of CCAMs requiring in utero resection. Journal of Surgical Research. 2006;130(2):285.
  17. Peranteau WH, Badillo AT, Zhang L, Chung S, Radu A, Zoltick PW, Liechty KW. Interleukin-10 overexpression in an adult model of dermal wound healing inhibits scar formation and decreases inflammatory cytokine production. Wound Repair and Regeneration. 2007;15(2):A24.
  18. Peranteau WH, Badillo AT, Zhang L, Chung S, Radu A, Zoltick PZ, Liechty KW. Lentiviral mediated overexpression of interleukin 10 inhibits scar formation in an adult murine model of dermal wound healing. Journal of Surgical Research. 2007;137(2):338- 339.
  19. Osterhoudt KC, Peranteau WH, Shaw KN, Flake AW. Dangerous attraction: A 2-year-old girl with enteric and mesenteric fistulae after ingestion of spherical magnetic toys. Clinical Toxicology 2011; 49: 548.
  20. Peranteau WH. Manipulation of the donor hematopoietic stem cell and fetal hematopoietic niche to optimize engraftment following IUHCT. Advances in Fetology. Cincinnati, Ohio 2013
  21. Yan L, Vrecenak JD, Li H, Jia H, Peranteau WH, Flake AW. Differential development of donor bone marrow-derived thymocytes after allogeneic in utero hematopoietic cell transplantation in the murine model. Advances in Fetology. Cincinnati, Ohio 2013
  22. Kovatis K, Zhang H, Peranteau W, Goldberg D, Connelly J, Rintoul N. A case of Avalon cannula malposition and successful conversion to V-A ECMO in a neonate. Extracorporeal Life Support Organization (ELSO) 24th Annual Meeting; Philadelphia 2013.
  23. Pearson EG, Vrecenak JD, Bhatti TR, Peranteau WH, Flake AW. Donor specific tolerance of renal allografts following haploidentical in utero hematopoietic cell transplantation in the canine model. Blood. 2013;122(21):2007.
  24. Partridge EA, Vrecenak JD, Kim AG, Kozlowski M, Flake AW, Peranteau WH. Posttranslational modification of the thrombopoietin receptor regulates cytokine signal transduction and hematopoietic stem cell engraftment. Blood. 2013;122(21):2452.
  25. Li Y, Vrecenak JD, Li H, Jia H, Peranteau WH, Flake AW. Differential development of donor bone marrow-derived thymocytes after allogeneic in utero hematopoietic cell transplantation in the murine model. Blood. 2013;122(21):4458.
  26. Partridge EA, Canning D, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Urologic and gastrointestinal complications of sacrococcygeal teratomas: prenatal and postnatal predictors. Presented at: American Pediatric Surgical Association Annual Meeting; Marco Island, FL (2013, May)
  27. Danzer E, Gerdes M, Ann J, Hoffman C, Bernbaum J, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with worse shortterm neurodevelopmental (ND) outcome in congenital diaphragmatic hernia (CDH). Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting. Vancouver, BC, Canada 2014.
  28. Mesas Burgos, C, Laje P, Davey M, Jia H, Pearson E, Flake A, Peranteau W. Prenatal sildenafil and dexamethasone respectively improve oxygenation and ventilation in the nitrofen model of congenital diaphragmatice hernia (CDH). American Pediatric Surgical Association Annual Meeting; Phoenix, AZ (2014, May)
  29. Boelig MM*, Conner M*, Kim A, Vrecenak J, Tsai J, Flake AW, Peranteau WH. Ex vivo modification of donor hematopoietic cells to enhance allogeneic engraftment following in utero hematopoietic cell transplantation (IUHCT). Conference of Fetal Therapies and Maternal-Fetal Tolerance. UCSF, San Francisco, CA (2014, April).
  30. E. Danzer, M. Gerdes, J. D’Agostino, J. Bernbaum, C. Hoffman, N.E. Rintoul, W.H. Peranteau, A.W. Flake, N.S. Adzick, H.L. Hedrick: Neurodevelopmental Outcome at One Year of Age in Congenital Diaphragmatic Hernia Infants Not Treated with ECMO. American Academy of Pediatrics National Conference and Exhibition, San Diego, CA (2014, October)
Oral Presentations
  1. Peranteau W. In utero hematopoietic stem cell transplantation and postnatal boosting. Presented at: The Children’s Hospital of Philadelphia, Department of Surgery Grand Rounds; Philadelphia, PA (2001, June)
  2. Peranteau W, Endo M, Adibe O, Merchant A, Zoltick P, Flake A. CD26 inhibition enhances allogeneic
    donor cell homing and engraftment after in utero bone marrow transplantation. Presented at: American College of Surgeons Annual Meeting; San Francisco, CA (2005, October)
  3. Peranteau W. Creation of a surrogate human immune system in a murine model by in utero transplantation. Presented at: Baylor Symposium and Workshop on Human Immunology and Biodefense; Dallas, TX (2005, October)
  4. Peranteau W, Gu Y, Volk S, Tuschong L, Bauer T, Badillo A, Kaye A, Johnson M, Hickstein D, Flake A.
    In utero hematopoietic cell transplantation using haploidentical parental donors reverses the lethal
    phenotype in dogs with canine leukocyte adhesion deficiency. Presented at: American Society of
    Hematology Annual Meeting; Orlando, FL (2006, December)
  5. Peranteau W, Badillo A, Zhang L, Chung S, Radu A, Zoltick P, Liechty K. Interleukin-10 overexpression in an adult model of dermal wound healing inhibits scar formation and decreases inflammatory cytokine production. Presented at: Wound Healing Society Annual Meeting; Tampa Bay, FL (2007, April)
  6. Peranteau W, Heaton T, Badillo A, Gu Y, Volk S, Tuschong L, Bauer T, Johnson M, Hickstein D, Flake A. Haploidentical in utero hematopoietic cell transplantation and postnatal minimally myeloablative
    transplants in a canine model. Presented at: American Pediatric Surgical Association Annual Meeting;
    Orlando, FL (2007, May)
  7. Peranteau W. In utero hematopoietic cell transplantation and postnatal boosting in the canine model.
    Presented at: The Children’s Hospital of Philadelphia, Department of Surgery Grand Rounds; Philadelphia, PA (2007, February)
  8. Peranteau W. Pediatric Surgery-The Unborn Patient. Presented at: The Boston Veteran’s Affairs Hospital, West Roxbury Campus, Department of Surgery Grand Rounds; West Roxbury, MA (2009, December)
  9. Rogers S, Powers P, Peranteau WH, Havens J, Gates JD, Russell R, Riviello R, Dyer G. The BWH
    Surgical Response to Haiti. Presented at: The Brigham and Women’s Hospital, Department of Surgery
    Grand Rounds; Boston, MA (2010, March)
  10. Peranteau W. Pediatric Penetrating Anorectal Trauma. Presented at: The Annual Day of Trauma sponsored by The Trauma Directors of the Philadelphia Area; The Union League, Philadelphia PA (2010, December 4)
  11. Peranteau W. Surgical Management of Insulinoma. Presented at: The Annual Nursing Conference, The
    Children’s Hospital of Philadelphia; Philadelphia, PA (2011, November)
  12. Peranteau W. In Utero Cellular and Gene Therapy; Another Frontier in Fetal Surgery. Presented at: The Children’s Hospital of Philadelphia, Department of Surgery Grand Rounds; Philadelphia, PA (2012,
    March)
  13. Peranteau W. In Utero Cellular and Gene Therapy; Another Frontier in Fetal Surgery. Presented at: The Children’s Hospital of Philadelphia, Post Anesthesia Care Unit (PACU) Annual Meeting; Philadelphia, PA (2012, October)
  14. Peranteau W. Mediastinal Masses. Presented at: The Children’s Hospital of Philadelphia, Department of Surgery Grand Rounds; Philadelphia, PA (2012, November)
  15. Peranteau W. ECMO: Cannulation and Decannulation in the Neonate. Presented at: The Children’s
    Hospital of Philadelphia, NeoSurgical Nursing Education Day (2013, January)
  16. Peranteau W. Fetal Lung Masses. Presented at: The Children’s Hospital of Philadelphia, SDU Education and Practice Improvement Series (2013, March)
  17. Peranteau W, Moldenhauer J, Rintoul N. Integrated Perinatal Management of Fetuses with Complex
    Anomalies. Presented at: The Center for Fetal Diagnosis and Treatment and the Neonatal Outreach
    Program at The Children’s Hospital of Philadelphia lecture series on “Optimizing Perinatal care for Fetuses with Congenital Anomalies” in Bethlehem, PA (2013, April 10)
  18. Peranteau WH. Manipulation of the donor hematopoietic stem cell and fetal hematopoietic niche to
    optimize engraftment following IUHCT. Advances in Fetology. Cincinnati, Ohio (2013, October)
  19. Peranteau WH. In-utero hematopoietic stem cell transplantation: A new paradigm in the management of Sickle Cell Disease. Care of the Surgical Neonate: The Nuts and Bolts. The Children’s Hospital of
    Philadelphia. Philadelphia, PA (2014, March)
  20. Peranteau WH. Prenatal and Postnatal Diagnosis and Management of Sacrococcygeal Teratoma. Neo-
    Surgical Conference. The Children’s Hospital of Philadelphia. Philadelphia, PA (2014, April)
  21. Peranteau WH. Ex vivo manipulation of donor hematopoietic stem cells to optimize in utero hematopoietic cell transplantation. Fetal Therapies and Maternal-Fetal Tolerance Conference, UCSF, San Francisco, CA (2014, April)
  22. Peranteau WH. Mediastinal Masses. Presented at: The Children’s Hospital of Philadelphia, Department of Surgery Grand Rounds; Philadelphia, PA (2014, May)
  23. Peranteau WH. ECMO Decannulation. Presented at The Children’s Hospital of Philadelphia, ECMO
    Specialist Training Day (2014, November)
Poster Presentations
  1. Peranteau W, Badillo A, Hedrick H, Flake A, Adzick N, Liechty K. The role of mesenchymal regulatory
    genes in the pathogenesis of CCAMs requiring in utero resection. Presented at: First Annual Academic
    Surgical Congress of the Association for Academic Surgery and the Society of University Surgeons; San
    Diego, CA (2006, February)
  2. Peranteau W, Hardy O, Alavi A, Pawel B, Stanley C, Adzick N. The use of PET scan to identify ectopic
    pancreatic tissue responsible for congenital hyperinsulinism. Presented at: American Pediatric Surgical
    Association Annual Meeting; Hilton Head, SC (2006, May)
  3. Peranteau W, Badillo A, Zhang L, Chung S, Radu A, Zoltick P, Liechty K. Lentiviral mediated
    overexpression of interleukin-10 inhibits scar formation in an adult model of dermal wound healing.
    Presented at: Second Annual Academic Surgical Congress of the Association for Academic Surgery and
    the Society of University Surgeons; Phoenix, AZ (2007, February)
 
Awards and Honors
2010 Robert T. Osteen Teaching Award, The Brigham and Women’s Hospital and Harvard Medical School
 
2010 Tufts University School of Medicine, Surgery Resident Teaching Award
 
2008 Tufts University School of Medicine, Surgery Resident Teaching Award
 
2007 John A. Mannick Research Award, The Brigham and Women's Hospital
 
2006 The Children's Hospital of Philadelphia Annual Research Award, The Children's
Hospital of Philadelphia
 
2002 I.S. Ravdin Surgery Award, University of Pennsylvania School of Medicine
 
2001 - 2002 President, Agnew Surgical Society, University of Pennsylvania School of Medicine
 
2000 - 2001 Howard Hughes Medical Institute Research Training Fellow, University of Pennsylvania
School of Medicine
 
1997 War Memorial Trophy for Outstanding Contribution to the Sport of Swimming,
Princeton University
 
1997 All-Ivy League Academic Honors, Men's Swimming and Diving, Princeton University
 
1997 All Academic Team, NCAA Division I Swimming and Diving, Princeton University
 
1997 NCAA Postgraduate Scholarship, Princeton University
 
1996 Jabez Pierson Pennington Memorial Scholarship for Outstanding Academic
Achievement, Princeton University
 
1996 All Academic Team, Honorable Mention, NCAA Division I Swimming and Diving,
Princeton University
 
1996 All-Ivy League Academic Honors, Men's Swimming and Diving, Princeton University
 
1995 William Pierson-Hibben Memorial Scholarship for Outstanding Scholarship
Character and Promise, Princeton University
 
1993 - 1997 Garden State Scholar, The State of New Jersey

William Peranteau

 
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