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Ivona Percec, M.D., Ph.D.
Plastic Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
10 Penn Tower
Philadelphia, PA 19104
Administrative Assistant: Wadia Timazee
Administrative Telephone: 215-662-7543
Administrative Fax: 215-615-3397

Clinical Office:
Perelman Center for Advanced Medicine
Center for Human Appearance
Suite 1-150E
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-662-7543
Clinical Fax:
215-615-3397

Contact Information (internal use only)

ivona.percec@uphs.upenn.edu

 

Ivona Percec completed undergraduate work at Princeton University in 1995. She received an A.B. degree in Molecular Biology with a minor in Medieval Studies, writing senior theses in both disciplines. She was awarded the Joseph Strayer Prize for Best Medieval Studies Thesis for her discussion on medicine in fourteenth-century France. She conducted undergraduate research in genomic imprinting with Shirley Tilghman, and subsequently pursued her research interests in the molecular genetics of brain tumors with Peter Black at Harvard University.

In 1996 Ivona entered the M.D./Ph.D. tract at Case Western Reserve University and began dissertation work in genetics with Hunt Willard. She transferred to the M.D./Ph.D. Program at the University of Pennsylvania in 1999 after starting a research collaboration between the two schools. Ivona Percec completed three years of the M.D./Ph.D. tract at Case Western Reserve University where she was awarded a Genetics NIH Training Grant. At the University of Pennsylvania, she worked with Marisa Bartolomei and was awarded a Radiation Oncology NIH Training Grant.

In 2002 Ivona was awarded both the John Clark and the Saul Winegrad awards for her dissertation work on X chromosome inactivation that was published in Science. She has given platform presentations at six international meetings, and was a Student Award Finalist at the 2001 American Society for Human Genetics Annual Meeting. She received her Ph.D. from the Cellular and Developmental Biology Department at the University of Pennsylvania in 2002. During the clinical years she was an editorial assistant for Emedicine Online. Ivona was elected to Senior Alpha Omega Alpha and the Outstanding Student Honor Societies in 2004. She was awarded the American Medical Womens Association Glasgow-Rubin Achievement Citation and the Merck Manual Award during the University of Pennsylvania School of Medicine Commencement where she also delivered the student address.

 
Faculty Appointments
2012 - present Assistant Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
   
2010 - 2012 Instructor in Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2010 - present Active Physician
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
 
Education/Training
1995 A.B. Princeton University
Princeton, New Jersey
 
2004 M.D./Ph.D
University of Pennsylvania School of Medicine
Philadelphia Pennsylvania
 
Post Graduate Training
2004 - 2005 PGY-1 General Surgery Intern
Hospital of University of Pennsylvania
Philadelphia, Pennsylvania
 
2005 - 2007 PGY-2/PGY-3 General Surgery Resident
Hospital of University of Pennsylvania
Philadelphia, Pennsylvania
 
2007 - 2010 PGY-4/PGY-6 Plastic Surgery Resident
Hospital of University of Pennsylvania
Philadelphia, Pennsylvania
 
Memberships/Societies
  • American Board of Plastic Surgery (ABPS)- Diplomate
  • Member, Plastic Surgery Research Council (PSRC)
  • Associate Member, Institute for Translational Medicine and Therapeutics (ITMAT)
    University of Pennsylvania
  • Member, International Federation for Adipose Therapeutics and Science (IFATS)
  • Fellow, Institute of Aging (IOA), University of Pennsylvania
 
 
 
 
 
 
Research
 

2010 - Present – Establishment of the soft tissue aging laboratory at the University of Pennsylvania. Examination of the genetic and epigenetic changes that occur with aging of subcutaneous adipose tissue deposits. Principal Investigator, Ivona Percec M.D. Ph.D.

2008 - 2010 – Examination of FGFR2 genotype and phenotype correlations in patients with Apert, Crouzon and Pfeiffer syndromes. In collaboration with Scott Bartlett M.D., Division of Plastic Surgery, University of Pennsylvania.

2004 - 2008 – Examination of the effects of radiation therapy on patients undergoing prosthetic breast reconstruction. Investigation of the differential effect of fat grafting techniques on adipose tissue viability in autogenous fat grafting. In collaboration with Louis Bucky M.D., Division of Plastic Surgery, University of Pennsylvania.

1999 - 2002 – Identification and characterization of dominant mutations of the X chromosome inactivation pathway in the mouse. Laboratory of Marisa Bartolomei PhD, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine.

1999 - 2002 - Identification and characterization of dominant mutations of the X chromosome inactivation pathway in the mouse. Laboratory of Marisa Bartolomei PhD, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine.

1998 - 1999 – Mouse mutagenesis screen for ENU-induced dominant mutations causing skewed X chromosome inactivation. Laboratory of Hunt Willard PhD, Chairman of Department of Genetics and Director of Center for Human Genetics, Case Western Reserve University School of Medicine.

1997 (Summer) – Construction of cDNA microarrays to examine gene expression in homocysteine metabolism. Laboratory of Joseph Nadeau PhD, Department of Genetics, Case Western Reserve University School of Medicine.

1997 (Spring) – Molecular characterization of marker chromosomes in Turner Syndrome patients with severe phenotypes. Laboratory of Hunt Willard PhD, Chairman of Department of Genetics and Director of Center for Human Genetics, Case Western Reserve University School of Medicine.

1995 - 1996 – Genetic and molecular characterization of human brain tumors. Laboratory of Peter Black MD, PhD, Neurosurgeon in Chief, Department of Neurosurgery, Children’s Hospital, Brigham and Womens Hospital and Harvard University School of Medicine

1994 - 1995 – Allelic inactivation of Pax-3 gene in mouse embryos. Laboratory of Shirley Tilghman PhD, Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University.

1993 (Summer) – Structural analysis of synthetic proteins. Laboratory of David Tirrell PhD, University of Massachusetts, Amherst.

1992 (Summer) – Biomolecular computer modeling of self-assembling macromolecules. Laboratory of John Blackwell PhD, Department of Macromolecular Science, Case Western Reserve University.

 
Publications
 
Original Papers
  1. Percec, I., Bucky, LP. Successful prosthetic breast reconstruction after radiation therapy. Annals of Plastic Surgery. 60 (5):527-31, May
    2008.
  2. Percec, I., Bucky, LP. The Science of Autologous Fat Grafting: Views on
    Current and Future Approaches to Neoadipogenesis. Aesthetic
    Surgery Journal. 313-321, May-June 2008.
  3. Percec, I, Thorvaldsen, JL, Plenge, RM, Krapp, CJ, Nadeau, JH, Willard,
    HF, Bartolomei, MS. An ENU Mutagenesis Screen for Epigenetic
    Mutations in the Mouse. Genetics. 164, 1481-1494, 2003.
  4. Percec, I, Plenge, RM, Nadeau, JH, Bartolomei, MS, Willard, HF.
    Autosomal Dominant Mutations Affecting X Inactivation Choice
    in the Mouse. Science. 296, 1136-1139, 2002.
  5. Percec, I, Bartolomei, MS. Do X Chromosomes Set Boundaries? Science.
    295, 287-288, 2002.
  6. Plenge, RP, Percec, I, Nadeau, JH, Willard HF. Expression-based assay of
    an X-linked gene to examine effects of the X-controlling element
    (Xce) locus. Mamm. Genome. 11, 405-408, 2000.
  7. Carroll, RS, Black, PM, Zhang, J, Kirsch, M, Percec, I, Lau, N, Guha, A.
    Expression and Activation of epidermal growth factor receptors in
    meningiomas. J Neurosurg. 87, 315-323, 1997.
Book Chapters
  1. Percec, I, Reid, R, Bartlett, S. “Distraction of the Craniofacial Skeleton:
    Experience at the University of Pennsylvania” in Distraction
    Osteogenesis of the Craniomaxillofacial Skeleton, The People’s
    Hygiene Publisher, Beijing, China. In Press.
  2. Percec, I, Reid, R, Bartlett, S. “Distraction Osteogenesis of the Midface”
    in Handbook of Craniofacial Surgery. In Press.
Dr. Ivona Percec
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