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Paige M. Porrett, M.D., Ph.D.
Transplant Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
2 Dulles, Liver Transplant Program
3400 Spruce Street
Philadelphia, PA  19104
Administrative Assistant: Tiffini C. Sykes
Telephone: 215-614-0947
Fax: 215-615-4900

Clinical Offices:
Perelman Center for Advanced Medicine
West Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-662-7453
Fax: 215-615-4900

Contact Information (internal use only)

paige.porrett@uphs.upenn.edu

 

Paige Porrett, MD, PhD, is the most recent addition to the transplant faculty.  She grew up in a small town in Michigan and then moved to Chicago to obtain a BA in French and her subsequent MD at Northwestern University.  Dr. Porrett came to Penn in 2001 to begin her general surgery residency and stayed for her abdominal organ transplant fellowship, completed in 2012.  She also completed a PhD in Immunology under the tutelage of Larry Turka, MD at Penn, and maintains a strong interest in understanding how the activated innate immune system prevents transplantation tolerance.  Her continued studies hope to elucidate the role of the inflammasome in tolerance blockade as well as define which proinflammatory cytokines represent key barriers to tolerance induction.  Her clinical research projects have focused primarily on the efficacy and benefit of locoregional therapy in HCC patients awaiting liver transplantation. Dr. Porrett has authored or co-authored 13 manuscripts and 6 book chapters, and she has had the privilege of editing two editions of The Surgical Review. She has been actively involved as a Fellow in ASTS activities and looks forward to expanding her involvement in the ASTS over the next several years.

 
Faculty Appointments
 
Hospital and Administrative Appointments
2013 - present Assistant Professor of Surgery
University of Pennsylvania Medical School
Philadelphia, PA
 
2012 - 2013

Clinical Instructor in Surgery
University of Pennsylvania Medical School
Philadelphia, Pennsylvania

 
Other Appointments
1996 - 1998 Physics Teaching Assistant
Northwestern University Center for Talent Development
Evanston, Illinois
 
2012 - present Instructor in Surgery, Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
 
Education/Training
2005 - 2008 Ph.D., University of Pennsylvania
Philadelphia, Pennsylvania
(Immunology; Mentor: Laurence Turka)
 
1997 - 2001 M.D., Northwestern University
Chicago Illinois
 
1993 - 1997 B.A., Northwestern University
Evanston, Illinois (French)
 
Postgraduate Training and Fellowship Appointments
2010 - 2012 Fellow in Abdominal Organ Transplantation
Department of Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2002 - 2010  Resident in General Surgery, Department of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Memberships/Societies
 
National/International Societies
2014 - present American Association of Reproductive Immunologists
 
2012 - present American Association of Immunologists
 
2010 - present  American Society of Transplant Surgeons
 
 
 
 
 
 
Research
 
 
 
 
 
 
 
 
 
 
Publications
 
Research Publications, Peer Reviewed
  1. Porrett PM, Desai SS, Timmins KJ, Twomey CR, Sonnad SS, Olthoff KM.  Combined orthotopic heart-liver transplantation: The need for exception status listing.  Liver Transplantation 10(12):1539-1544, Dec. 2004.
  2. Porrett P, Sonnad S, Timmons K, Rosen M, Furth E, Soulen M, Olthoff K.  Lack of benefit of pre-transplant locoregional hepatic therapy for hepatocellular carcinoma in the current MELD era.  Liver Transplantation 12(4):665-673, Apr. 2006.
  3. Lee MK IV, Moore DJ, Chiaccio M, Lian MM, Deng S, Mohiuddin M, Huang X, Koeberlein B, Zacheim A, Porrett P, Barker C, Caton AJ, Markmann JF.  T-reg mediated suppression of the allograft response in the draining lymph node.  Transplantation 81(7):1063-1066, Apr. 15, 2006.
  4. Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA.  Cutting edge: T cell requirement for CD28 costimulation is due to            negative regulation of TCR signals by PTEN.  Journal of Immunology 177(7):4262-4266, Oct. 1, 2006.
  5. Porrett PM, Yeh, Heidi, Frank AM, Deng S, Kim JI, Barker C, Markmann JF.  Availability of suitable islet donors in the United States.  Transplantation 84(2):280-282, July 27, 2007.
  6. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW.  Deacetylase inhibition promotes the generation and function of regulatory T cells.  Nature Medicine 13(11):1299-1307, Nov. 2007 [Epub Oct. 7, 2007].
  7. Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O’Shea JJ, Hunter CA.  Interleukins 27 and 6 induce STAT3-mediated T cell production of IL-10.  Nature Immunology 8(12):1363-1373, Dec. 2007 [Epub Nov. 11, 2007].
  8. Porrett PM, Lee MK IV, Lian MM, Wang J, Caton AJ, Deng S, Markmann JF, Moore DJ.  A direct comparison of rejection by CD8 and CD4 T cells in a transgenic model of allotransplantation.  Arch Immunologiae et Therapiae Experimentalis 56(3):193-200, May/June 2008 [Epub May 30, 2008].
  9. Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Hancock WW, Sayegh MH, Koulamanda M, Strom TB, Turka LA.  Mechanisms underlying blockade of allograft acceptance by TLR ligands.  Journal of Immunology 181(3):1692-1699, Aug. 1, 2008.
  10. Allenspach EJ, Lemos MP, Porrett PM, Turka LA, Laufer TM. Migratory and lymphoid-resident dendritic cells cooperate in lymph nodes for efficient CD4+ T cell priming.  Immunity 29(5):795-806, Nov. 14, 2008 [Epub Oct. 23, 2008].
  11. Porrett PM, Kamoun M, Parsons R, Bloom R, Goral S, Reese P, Grossman R, Baluarte J, Bleicher M, Levine M, Barker CF, Olthoff KM, Naji A, Shaked A, Abt PL.  Kidney transplantation at The University of Pennsylvania: 1998-2008.  Clinical Transplants: 2009 143-152, 2009.
  12. Porrett P, Shaked A.  The failure of immunosuppression withdrawal: Patient benefit is not detectable, inducible, or reproducible.  Liver Transplantation 17:S66-68, 2011.
  13. Porrett PM, Levine ML.  Fever and suprapubic tenderness ten days after kidney transplantation.  American Journal of Transplantation 12(1):254-256, Jan. 2012.
  14. Porrett PM, Horst MT, Shaked A.  Donor assessment scores: Relevance and complete irrelevance.  Liver Transplantation July 5, 2012 [Epub ahead of print].
Reviews in Peer Reviewed Research Publications
  1. Porrett PM, Hsu J, Shaked A.  Late surgical complications following liver transplantation. [Review] Liver Transplantation 15(Suppl 2):S12-18, Nov. 2009.
  2. Murphy SP, Porrett PM, Turka LA.  Innate immunity in transplant tolerance and rejection. [Review] Immunology Reviews 241(1):39-48, May 2011.
  3. Porrett P and Olthoff KM.  “Current State of Living Donor Liver Transplantation”.  Submitted, Clinical Liver Disease 2013
Abstracts (Last 3 Years)
  1. Hsu EK, Porrett PM, Olthoff K, Rand EB.  Pediatric mortality on the liver transplant wait list: A single center 15 year experience.  AASLD Single Topic Conference: Pediatric Liver Transplantation, Atlanta, GA, 2011.
  2. Mu Y, Abt PL, Levine MH, Porrett PM, Ottmann SE, Olthoff KM, Shaked A.  Survival after tumor resection of HCC single metastases following liver transplantation.  American Journal of Transplantation 11(Suppl 2):463, 2011.
  3. Porrett P, Cui R, Sonnad S, Ottmann S, Drazek D, Hoteit M, Olthoff K, Shaked A, Levine M.  Prolonged wait list time does not negatively impact oncologic outcome in patients transplanted with HCC.  American Journal of Transplantation 11(Suppl 2):463, 2011.
  4. Porrett P, Cui R, Sonnad S, Ottmann S, Drazek D, Hoteit M, Olthoff K, Shaked A, Levine M.  Impact of true MELD on post-transplant outcome in patients listed with exception MELD HCC points.  American Journal of Transplantation 11(Suppl 2):463, 2011.
  5. Levine M, Porrett P, Cui R, Ottmann S, Hoteit M, Abt P, Furth E, Siegelman E, Rosen M, Olthoff K, Shaked A.  Unexpected multicentricity in liver explant data from 358 consecutive liver transplants for HCC: Implications for resection of HCC in cirrhotic patients.  American Journal of Transplantation 11(Suppl 2):464, 2011.
  6. Levine MH, Sonnad S, Porrett P, Ottmann S, Cui R, Hoteit M, Rosen M, Siegelman E, Furth E, Olthoff K, Shaked A.  The predictive value of Milan criteria for liver transplantation for hepatocellular carcinoma is derived from correlation with explant liver pathology.  American Journal of Transplantation 11(Suppl 2):464, 2011.
  7. Porrett P, Cui R, Malik S, Hasz R, Grzybowski M, Reddy KR, Olthoff KM, Shaked A.  Transplant outcomes in recipients of allografts declined for higher MELD score candidates.  Hepatology 54(S1):168A, 2011.
  8. Porrett P.  Prolonged wait list time does not negatively impact oncologic outcome in patients transplanted with HCC.  Poster presentation at the Twelfth Annual American Transplant Congress, Philadelphia, PA, May 2011.
  9. Porrett P.  Transplant outcomes in recipients of allografts declined for higher MELD Score Candidates. Poster presentation at the American Association for the Studyof Liver Diseases 62nd Annual Meeting, San Francisco, CA, Nov. 2011.
  10. Porrett P, Malik S, Cui R, Ottmann S, Drazek D, Hoteit M, Abt P, Shaked A, Olthoff K, and Levine MH.  “Increasing Wait Time Does Not Adversely Impact Wait List or Transplant Outcomes in Patients with HCC.”  Amer J Transpl 2012; 12 (s3): p.37.
  11. Baranov E, ter Horst M, Porrett PM.  “Serum albumin identifies patients at high risk for removal from the liver transplant list.”Amer J Transpl 2013; 13(S2): 81.
  12. Stevens D, Trofe-Clark J, Blumberg E, Wilck M, Weikert B, Goral S, Bleicher M, Sawinski D, Abt P, Levine M, Porrett P, Bloom R.  “Increased risk of breakthrough infection among cytomegalovirus donor positive/recipient negative kidney transplant recipients receiving lower dose valganciclovir prophylaxis.” Amer J Transpl 2013: 13(S5): 321.
  13. Gupta M, Porrett P, Goldberg D, Abt P, and Levine M.“True MELD score is associated with HCC patient outcomes after liver transplant”. Amer J Transpl 2013: 13(S5): 46.
  14. Porrett P, Baranov E, Shaked A, and Olthoff K.  “Outcomes of transplantation for uncontrolled HCC and rescue with marginal quality grafts.”  Amer J Transpl 2013; 13(S5): 46.
Editorials, Chapters, Case Reports & Participation in Committee Reports
  1. Lerner SM, Porrett PM, Markmann JF, Busuttil RW.  Retransplantation of vital organs. Chap. in Stuart FP, Abecassis MM, Kaufman DB (eds.): Organ Transplantation, 2nd Edition.  Georgetown: Landes Bioscience, 2003, 528-538.
  2. Porrett PM, Olthoff KM.  Hepatobiliary system.  Sect. I, Chap. 15 in Atluri P, Karakousis G, Porrett PM, Kaiser LR (eds.): The Surgical Review, 2nd Edition. Philadelphia: Lippincott, Williams and Wilkins, 2006, 223-239.
  3. Porrett PM, Olthoff KM.  Hepatectomy.  Chap 13 in Kanchwala S, Paulson EC, Roses R (eds.): Gowned and Gloved Surgery: Introduction to Common Procedures. Philadelphia: Elsevier Health Sciences, 2008, 102-113.
  4. Porrett PM, Olthoff KM.  Hepatobiliary system.  Sect. II, Chap. 13 in Porrett PM, Frederick J, Roses R, Kaiser LR.  The Surgical Review, 3rd Edition. Philadelphia: Lippincott, Williams and Wilkins, 2009, 159-175.
  5. Porrett PM, Olthoff KM.  Outcomes of living donor transplantation: Western perspective.  Chap. in Busuttil R, Klintmalm G (eds.): Transplantation of the Liver, 3rd Edition.  Philadelphia: Elsevier, 2013 (in press).
Books
  1. Atluri P, Karakousis G, Porrett PM, Kaiser LR.  The Surgical Review, 2nd Edition. Philadelphia: Lippincott, Williams and Wilkins, 2006.
  2. Porrett PM, Frederick J, Roses R, Kaiser LR.  The Surgical Review, 3rd Edition. Philadelphia: Lippincott, Williams and Wilkins, 2009.
 
Honors and Awards
2010   Leonard J. Perloff Chief Resident Award
(for contribution to junior resident education)
 
2010 & 2003 Penn Pearl Award (Excellence in medical student teaching)
 
2009 Keith Reemstma surgical resident of the year award
 
2008 AASLD/ALF Travel Award.  The Liver Meeting, San Francisco.
 
2006 - 2007 William Inouye Award (Excellence in medical student teaching)    
 
2000 Julius Conn Award (Performance during a surgical rotation)
 
2000 AOA society induction.
 
1996 Outstanding undergraduate research thesis

Dr. Paige Porrett

 
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