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Steven E. Raper, M.D.
Gastrointestinal Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
4 Silverstein Pavilion
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Administrative Assistant: Rene Wilson
Administrative Telephone: 215-349-8155
Administrative Fax: 215-349-8195
Patient Appointments: 215-662-2626

Clinical Office:
Perelman Center for Advanced Medicine
GI Surgery
West Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104

Contact Information (internal use only)

rapers@uphs.upenn.edu

 

Dr. Raper has expertise in benign biliary tract disease; especially laparoscopic cholecystectomy. While on the faculty there, he performed the first laparoscopic cholecystectomy at the University of Michigan Medical Center, and has remained a champion for the performance of this common, important, but technically complex operation.

Dr. Raper is also interested in revisional gastrointestinal surgical problems; in particular the management of surgical complications of bariatric surgery and of enterocutaneous fistulous disease. The renaissance of interest in and proliferation of surgical procedures for the treatment of morbid obesity has created new problems in the management of these complex patients. Management of GI fistulas often require a multidisciplinary approach, and fit well with the mission of the University of Pennsylvania Health System as a quaternary referral center.

A third area of interest is in the surgical repair of large, complex hernias. Such hernias may arise spontaneously or as a result of prior surgical procedures. Abdominal wall reconstruction after prior surgery can be a challenging problem, especially in the obese individual. Frequently, Dr. Raper will work with colleagues in other disciplines to enhance the chances of a successful outcome in these complex cases.

Lastly, Dr. Raper maintains a busy practice in the ‘bread and butter’ procedures, such as inguinal hernias, enteric tube access (percutaneous and open gastrostomy, tube jejunostomy), and port placement for chemotherapy or parenteral nutrition.

 
Faculty Appointments
1999 - present Associate Professor of Surgery (with tenure)
Perelman School of Medicine
Philadelphia, Pennsylvania
 
1994 - 1999 Associate Professor of Surgery,
University of Pennsylvania
Philadelphia, Pennsylvania
 
1993 - 1994 Assistant Professor, Department of Surgery
University of Pennsylvania
Philadelphia, Pennsylvania
 
1987 - 1993 Assistant Professor, Department of Surgery
University of Michigan
Ann Arbor, Michigan
 
Hospital and Administrative Appointments
2008 - 2009 Chief, Surgery, Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2005 - 2006 Associate Chief of Staff, Surgical Service
Philadelphia Veteran's Affairs Medical Center Philadelphia, Pennsylvania
 
1998 - present Active Surgeon
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
1997 - 2000 Associate Chief of Staff, Surgical Service
Philadelphia Veteran's Affairs Medical Center Philadelphia, Pennsylvania
 
1994 - 2000 Director, Surgical Critical Care
Philadelphia Veteran's Affairs Medical Center Philadelphia, Pennsylvania
 
1993 - present Active Surgeon
Philadelphia Veteran's Affairs Medical Center
Philadelphia, Pennsylvania
 
1993 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Institute for Human Gene Therapy
1996 - 2000 Co-chair, Animal Resources Advisory Committee, IHGT
 
1996 - present Faculty Adviser, Translational Research Program, IHGT
 
1995 - 2001 Member, Toxicology Management Committee
IHGT
 
1995 - 1996 Interim Director, Animal Services Unit, IHGT
 
1994 Chair, Director Animal Models Core Search
Committee
 
1993 - 1994 Director, Animal Models Core
Institute for Human Gene Therapy
University of Pennsylvania
 
1993 - 1995 Member, Executive Committee
Institute of Human Gene Therapy (IHGT)
 
Department of Surgery/School of Medicine
 1995 - present Resident Selection Committee, Surgery
 
1995 - 2000 Member, Respiratory Treatment Committee, HUP
 
1994 - 2000 Member, Housestaff Supervision Committee, HUP
 
1994 - 2000 Director, Surgical Critical Care
Philadelphia Veteran's Affairs Medical Center
 
1997 - 2000 Associate Chief of Staff, Surgical Service
Philadelphia Veteran's Affairs Medical Center
 
University of Pennsylvania
1999 Member, Research Animal Services Committee
 
1998 - 1999 Chairman, Red Team, Penn IACUC
 
1995 - 1999 Member, Penn IACUC
 
National Societies/Appointments
1997 - 2000 Program Committee,
Society for Surgery of the Alimentary Tract
 
1999 Board of Trustees,
Society for Surgery of the Alimentary Tract
 
1999 Expert Panel Member, RPRC Full Review, NIH/NCRR
 
Education/Training
2007 - 2012 J.D.
University of Pennsylvania, Philadelphia, Pennsylvania
 
1976 - 1980 M.D.
University of Illinois, Chicago, Illinois
 
1972 - 1976 B.S. (microbiology)
University of Illinois, Champaign-Urbana, Illinois
 
Postgraduate Training and Fellowship Appointments
1986 - 1987 Chief Resident in Surgery
University of California, San Francisco, California
 
1985 - 1986 Senior Resident in Surgery
University of California, San Francisco, California
 
1983 - 1985 Chief Resident, Proctology Service
Veteran's Administration Medical Center
San Francisco, California
 
1983 - 1985

Research Fellow, Cell Biology
Veteran's Administration Medical Center
San Francisco, California

 
1981 - 1983 Resident in Surgery, University of California
San Francisco, California
 
1980 - 1981 Intern in Surgery, University of California
San Francisco, California
 
Memberships/Societies
 
National & International Societies
2004- present   International Society of Surgery
Chairman, Membership Committee (2004-2007)
 
2003 - present American Surgical Association
 
1995 - present American Pancreatic Association
 
1995 - present Pancreas Club
 
1994 - present Societe Internationale de Chirurgie
 
1993 - present Society for Surgery of the Alimentary Tract
Program Committee (1997-2000)
Board of Trustees (1999-2004)
 
1993 - present   Society of University of Surgeons
 
1991 - present  American Association for the Study of Liver Diseases
 
1990 - present  American College of Surgeons
 
1990 - present  Society of American Gastrointestinal Endoscopic Surgeon
 
1990 - present Association for Academic Surgery
 
1988 - present    American Society for Cell Biology
 
Local & Regional Societies
1995 - present Philadelphia Academy of Surgeons, Member
 
1994 - present John Morgan Society, Member
 
1993 - present  PENN Surgery Society, Member
 
1987 - present   Howard C. Nafziger Society, Member
 
Scientific Committees
1999 Expert Panel Member, RPRC Full Review, NIH/NCRR
 
Research

Dr. Raper’s research interests include a variety of legal topics, due in large part to his enrollment in Penn Law as a part-time law student.

Disclosure of adverse outcomes: He has completed a pilot project in which faculty members interact with a standardized patient while disclosing an adverse outcome. This is likely to be expanded into a course for select faculty members.

He is engaged in pro bono work in the following areas:

  1. Developing an informational piece for physicians on informed consent;
  2. Consulting on an informational document on the litigation process for physicians;
  3. Updating a legal reference guide.

Lastly he is engaged in the production of scholarly works regarding the limits of individual autonomy and health-care decision-making in an international context.

 
Publications
Research Publications, Peer-Reviewed
  1. Yee ES, Raper SE, Thomas AN, Ebert PA: Technical accuracy and clinical efficacy of thoracic computed tomography. American Journal of Surgery 144(1):35-43, July 1982.
  2. Burwen SJ, Barker ME, Goldman IS, Hradek GT, Raper SE, Jones AL: Transport of epidermal growth factor by rat liver: Evidence of a non-lysosomal pathway. Journal of Cell Biology 99(4 Pt 1):1259-1265, Oct. 1984.
  3. Goldman IS, Winkler ML, Raper SE, Barker ME, Keung E, Goldberg HI, Boyer TD: Increased hepatic density and phospholipidosis due to amiodarone. American Journal of Roentgenology 144(3):541-546, Mar. 1985.
  4. Duh QY, Gum ET, Gerend P, Raper SE, Clark OH: Epidermal growth factor receptors in normal and neoplastic thyroid tissue. Surgery 98(6):1000-1007, Dec. 1985.
  5. Duh QY, Gum ET, Sancho JJ, Levin KE, Raper SE, Clark OH: Epidermal growth factor receptors in parathyroid tissue. Journal of Surgical Research 40(6):569-573, June 1986.
  6. Bresalier RS, Hujanen ES, Raper SE, Roll FJ, Itzkowitz SH, Martin GR, Kim YS: An animal model for colon cancer metastasis: Establishment and characterization of cell lines with enhanced liver-metastasizing ability. Cancer Research 47(5):1398-1406, Mar. 1, 1987.
  7. Bresalier RS, Raper SE, Hujanen ES, Martin GR, Kim YS: A new animal model for human colon cancer metastasis. International Journal of Cancer 39(5):625-630, May 15, 1987.
  8. Raper SE, Burwen SJ, Barker ME, Jones AL: Translocation of epidermal growth factor to the hepatocyte nucleus during liver regeneration. Gastroenterology 92(5 Pt 1):1243-1250, May 1987.
  9. Raper SE, Barker ME, Burwen SJ, Jones AL: Isoflurane as an anesthetic for experimental animal surgery. Anatomical Record 218(2):116-122, June 1987.
  10. Eckhauser FE, Knol JA, Raper SE, Guice KS: Completion gastrectomy for postsurgical gas-troparesis syndrome: Preliminary results with 15 patients. Annals of Surgery 208(3):345-353, Sept. 1988.
  11. Eckhauser FE, Lloyd RV, Thompson NW, Raper SE, Vinik AI: Antrectomy for multicentric, argyrophil gastric carcinoids: A preliminary report. Surgery 104(6):1046-1053, Dec. 1988.
  12. Raper SE, Barker ME, Jones AL, Way LW: Anatomic correlates of bacterial cholangiovenous reflux. Surgery 105(3):352-359, Mar. 1989.
  13. Pomerantz RA, Eckhauser FE, Knol JA, Guice K, Raper SE, Turcotte JG: Operative timing and patient survival following distal splenorenal shunt. American Surgeon 55(6):333-337, June 1989.
  14. Pellegrini CA, Heck CF, Raper SE, Way LW: An analysis of the reduced morbidity and mortal-ity rates after pancreatoduodenectomy. Archives of Surgery 124(7):778-781, July 1989.
  15. Eckhauser FE, Raper SE: Peptic ulcer disease, gastrointestinal hemorrhage and hypercalcemia: multiple endocrine neoplasia syndrome, type I: Postgrad Gen Surg 2(2):61-6, 1990.
  16. Raper SE, Kothary PC, Kokudo N, DelValle J, Eckhauser FE: The liver plays an important role in the regulation of somatostatin-14 in the rat. American Journal of Surgery 161(1):184-189, Jan. 1991.
  17. Raper SE, Kothary PC, Kokudo N: Somatostatin-14 blocks the hepatotrophic effects of insulin in the rat. Journal of Surgical Research 50(4):386-390, Apr. 1991.
  18. Eckhauser FE, Raper SE, Knol JA, Mulholland MW, et al: Extracorporeal lithotripsy: An important adjunct in the nonoperative management of retained or recurrent bile duct stones. Archives of Surgery 126(7):829-835, July 1991.
  19. Kokudo N, Eckhauser FE, Kothary PC, Raper SE: Inhibitory effects of somatostatin on rat hepatocyte proliferation are mediated by cyclic AMP. Journal of Surgical Research 51(2):113-118, Aug.1991.
  20. Hirschl R, Eckhauser FE, Raper SE: Reconstruction of the abdominal wall by placement and early excision of prosthetic mesh. Surgery, Gynecology & Obstetrics 173(3):237-238, Sept. 1991.
  21. Guynn TP, Eckhauser FE, Knol JA, Raper SE, et al: Injection sclerotherapy-induced esophageal strictures: risk factors and prognosis. American Surgeon 57(9):567-572, Sept. 1991.
  22. Grossman M, Raper SE, Wilson JM: Towards liver-directed gene therapy: Retrovirus-mediated gene transfer into human hepatocytes. Somatic Cell & Molecular Genetics 17(6):601-607, Nov. 1991.
  23. Kokudo N, Kothary PC, Eckhauser FE, Nakamura T, Raper SE: Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor. American Journal of Surgery 163(1):169-173, Jan. 1992.
  24. Eckhauser FE, Knol JA, Raper SE, Mulholland MW, Helzerman P: Efficacy of two compara-tive antibiotic regimens in the treatment of serious intra-abdominal infections: Results of a multi-center study. Clinical Therapy 14(1):97-109, Jan./Feb. 1992.
  25. Wilson JM, Grossman M, Raper SE, Baker JR, Newton RS, and Thoene JG: Clinical Protocol: Ex vivo gene therapy of familial hypercholesterolemia. Human Gene Therapy 3(2):179-222, Apr. 1992.
  26. Raper SE, Kothary PC, Del Valle J: Identification and partial characterization of a somatostatin-14 binding protein on rat liver plasma membranes. Hepatology 16(2):433-439, Aug. 1992.
  27. Raper SE, Wilson JM, Grossman M: Retroviral-mediated gene transfer in human hepatocytes. Surgery 112(2):333-340, Aug. 1992.
  28. Kokudo N, Kothary PC, Eckhauser FE, Raper SE: Transforming growth factor (TGF-a) improves hepatic DNA synthesis after hepatectomy in cirrhotic rats. Journal of Surgical Research 52(6):648-655, June 1992.
  29. Grossman M, Raper SE, Wilson JM: Transplantation of genetically-modified autologous hepatocytes into non-human primates: Feasibility and short-term toxicity. Human Gene Therapy 3(5):501-510, Oct. 1992.
  30. Raper SE, Kothary PC, Kokudo N, Del Valle J: Hepatectomy impairs hepatic processing of somatostatin-14. American Journal of Surgery 165(1):89-95, Jan. 1993.
  31. Hashimoto M, Kothary PC, Raper SE: The effects of transforming growth factor alpha and somatostatin on the processing of liver regeneration in the rat. Regulatory Peptides 44(1):49-59, Mar. 5, 1993.
  32. Grossman M, Wilson JM, Raper SE: A novel approach for introducing hepatocytes into the portal circulation. Journal of Laboratory & Clinical Medicine 121(3):472-478, Mar. 1993.
  33. Yang Y, Raper SE, Cohn JA, Engelhardt JF, Wilson JM: An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proceedings of the National Academy of Sciences 90(10):4601-4605, May 15, 1993.
  34. Thornton AJ, Bruzdzinski CJ, Raper SE and Gelehrter TD. Plasminogen activator inhibitor-1 (PAI-1) is an immediate early response gene in regenerating rat liver. Cancer Research 54(5):1337-1343, Mar. 1, 1994.
  35. Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D and Wilson JM: Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nature Genetics 6(4):335-341, Apr. 1994.
  36. Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM. In vivo correction of low density lipoprotein receptor deficiency in the watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. Journal of Biological Chemistry 269(18):13695-13702, May 6, 1994.
  37. Eckhauser FE, Knol JA, Raper SE, Thompson NW. Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma. American Surgeon 60(7):466-471, July 1994.
  38. Bhora FY, Kothary PC, Imanishi H, Raper SE. Vasopressin stimulates DNA synthesis in cultured rat hepatocytes. Journal of Surgical Research 57(6):706-710, Dec. 1994.
  39. DeMatteo RD, Markmann J, Raper SE. An improved technique of thymectomy in the adult mouse. Transplantation 59(5):787-789, Mar. 15, 1995.
  40. Imanishi H, Kothary PC, Bhora FY, Eckhauser FE, Raper SE. Impaired phorbol ester-induced hepatocyte proliferation in cirrhosis. Journal of Surgical Research 58(4):435-440, Apr. 1995.
  41. Gerkin TM, Eckhauser FE, Raper SE, Mulholland MW, Knol JA, Schork MA. Are traditional prognostic criteria useful in pancreatic abscess? Pancreas 10(4):331-337, May 1995.
  42. Raper SE, Kothary P, Ishoo E, Dikin M, Kokudo N, Hashimoto M, DeMatteo RP. Divergent mechanisms of insulin-like growth factor I and II on rat hepatocyte DNA synthesis. Regulatory Peptides 58:55-62, 1995.
  43. DeMatteo RP, Raper SE, Ahn M, Fisher KJ, Burke C, Widera G, Claytor B, Barker CF, Markmann JF. Gene transfer to the thymus: A means of abrogating the immune response to recombinant adenovirus. Annals of Surgery 222(3):229-242, Sept. 1995.
  44. Kothary PC, Kokudo N, Raper SE: Preferential suppression of insulin-stimulated proliferation of cultured hepatocytes by somatostatin: Evidence for receptor-mediated growth regulation. Journal of Cellular Biochemistry 59(2):258-265, Oct. 1995.
  45. Grossman M, Rader DJ, Muller DWM, Kolansky DM, Kozarsky K, Clark BJ, Stein EA, Lupien PJ, Brewer HB, Raper SE, Wilson JM. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nature Medicine 1(11):1148-1154, Nov. 1995.
  46. Hamilton TE, Koide S, Zhang W, Rombeau JL, Raper SE. Adenoviral mediated gene transfer to the small intestinal isograft. Transplantation Proceedings 28(5):2444, Oct. 1996.
  47. DeMatteo RP, Markmann JF, Barker CF, Raper SE. Prolongation of adenoviral transgene ex-pression in mouse liver by T lymphocyte subset depletion. Gene Therapy 3(1):4-12, Jan. 1996.
  48. Cabrera JA, Wilson JM, Raper SE. Targeted retroviral gene transfer into the rat biliary tract. Somatic Cell & Molecular Genetics 22(1):21-29, Jan. 1996.
  49. Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ, Kolansky DM, Muller DWM, Wilson JM. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Annals of Surgery 223(2):114-123, Feb. 1996.
  50. Raper SE, DeMatteo RP. Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Pancreas 12(4):401-410, May 1996.
  51. Raper SE. The four legged hepatocyte: Lessons learned about cholesterol metabolism from new technologies. Hepatology 24(2):463-465, Aug. 1996.
  52. Kucharczuk J, Raper S, Elshami A, Amin K, Sterman D, Wheeldon E, Wilson JM, Litzky L, Kaiser L, Albelda S. Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex virus thymidine kinase cDNA followed by ganciclovir in non-human primates. Human Gene Therapy 7(18):2225-2233, Dec. 1, 1996.
  53. Hamilton T, DeMatteo R, McClane S, Burke C, Rombeau J, Raper SE. Adenoviral-mediated gene transfer to murine small intestine is more efficient in neonates than adults. Journal of Pediatric Surgery 32(2):373-377, Feb. 1997.
  54. Fisher KJ, Jooss K, Alston J. Yang Y, Haecker SE, Pathak R, Raper SE, Wilson JM. Recombi-nant adeno-associated virus for muscle-directed gene therapy. Nature Medicine 3(3):306-312, Mar. 1997.
  55. McClane SJ, Hamilton TE, Burke CV, Raper SE. Functional consequences of adenovirus-mediated murine pancreatic gene transfer. Human Gene Therapy 8(6):739-746, Apr. 10, 1997.
  56. DeMatteo RP. Chu G. Ahn M. Chang E. Burke C. Raper SE. Barker CF. Markmann JF. Immuno-logic barriers to hepatic adenoviral gene therapy for transplantation. Transplantation 63(2):315-9, Jan. 1997.
  57. Smith JG, Raper SE, Wheeldon E, Hackney D, Judy K, Wilson JM, Eck SL. Intracranial adminis-tration of adenovirus expressing HSVTK in combination with ganciclovir produces a dose de-pendent, self-limiting inflammatory response. Human Gene Therapy 8(8):943-954, May 20, 1997.
  58. McClane S, Hamilton T, Burke C, Raper SE. The effect of adenoviral early genes and the host im-mune system on in vivo pancreatic gene transfer in the mouse. Pancreas 15(3):236-245, Oct. 1997.
  59. DeMatteo RP, McClane SJ, Fisher KJ, Yeh H, Chu G, Burke CV, Raper SE. Engineering tissue-specific expression of a recombinant adenovirus: Selective transgene transcription in the pan-creas using the amylase promoter. Journal of Surgical Research 72(2):155-161, Oct. 1997.
  60. Hamilton TE, McClane S, Baldwin S, Burke CV, Patel H, Rombeau JL, Raper SE. Efficient adenoviral-mediated murine neonatal small intestinal gene transfer is dependent in av integrin expression. Journal of Pediatric Surgery 32(12):1695-1703, Dec. 1997.
  61. McClane SJ, Chirmule N, Burke CV, Raper SE. Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Human Gene Therapy 8(18):2207-2216, Dec. 10, 1997.
  62. Raper SE, Haskal ZJ, Ye X, Furth EE, Pugh C, Wilson JM. Selective gene transfer into the liver of non-human primates with E1-deleted, E2a defective, or E1-E4 deleted recombinant adeno-viruses. Human Gene Therapy 9(5):671-679, Mar. 20, 1998.
  63. Chirmule N, Hughes JV, Gao G-P, Raper SE, Wilson JM. Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and non-human primate lungs. Journal of Virology 72(7):6138-6145, July 1998.
  64. Raper SE, Wilson JM, Yudkoff M, Robinson MB, Ye X, Batshaw ML. Developing adenoviral-mediated in vivo gene therapy for ornithine transcarbamylase deficiency. Journal of Inherited Metabolic Disease 21S1:119-137, 1998.
  65. Ye X, Gao G-P, Pabin C, Raper SE, Wilson JM. Evaluating the potential of germline trans-mission after intravenous administration of recombinant adenovirus in the C3H mouse. Human Gene Therapy 9(14):2135-2142, Sept. 1998.
  66. Hashimoto M, Kothary P, Raper SE. Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy. Journal of Gastroenterology & Hepatology 13(12):1259-1265, Dec. 1998.
  67. Hashimoto M, Kothary P, Raper SE. Phenobarbital in comparison with carbon tetrachloride and phenobarbital induced cirrhosis in rat liver regeneration. Journal of Surgical Research 81(2):164-169, Feb. 1998.
  68. Raper SE. Answering questions on a microscopic scale: The detection of circulating cancer cells. Surgery 126:827-828, 1999.
  69. DeMatteo RP, Yeh H, Friscia M, Capparelli D, Burke CV, Desai N, Chu G, Markmann JF, Raper SE, Barker CF. Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases. Annals of Surgical Oncology 6(1):88-94, Jan./Feb. 1999.
  70. Chirmule N, Truneh A, Haecker SE, Tazelaar J, Gao G-P, Raper SE, Hughes JV, Wilson JM. Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a non-depleting CD4 antibody. Journal of Immunology 163(1):448-455, July 1, 1999.
  71. Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE. Cell biological assessment of human glucokinase mutants causing maturity onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinemia. Biochemical Journal 342(Pt 2):345-352, Sept. 1, 1999.
  72. Batshaw ML, Wilson JM, Raper SE, et al. Clinical Protocol: Recombinant adenovirus gene transfer in adults with partial ornithine transcarbamylase deficiency (OTCD). Human Gene Therapy 10(14):2419-2437, Sept. 20, 1999.
  73. Nunes FA, Furth EE, Wilson JM, Raper SE. Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: Safety of readministration. Human Gene Therapy 10(15):2515-2526, Oct. 10, 1999.
  74. Raper SE. Acute pancreatitis secondary to dehydration: Case report and review of the literature. American Surgeon 65(11):1084-1087, Nov. 1999.
  75. Chirmule N, Raper SE, Burkly L, Thomas D, Tazelaar J, Hughes JV, Wilson JM. Readministra-tion of adenoviral vector in non-human primate lungs by blockade of CD-40-CD40L interact-tions. Journal of Virology 74(7):3345-3352, Apr. 2000.
  76. McCullough B, Yudkoff M, Batshaw ML, Wilson JM, Raper SE, Tuchman M. Genotype spec-trum of ornithine transcarbamylase deficiency: Correlation with the clinical and biochemical phenotype. American Journal of Medical Genetics 93(4):313-319, Aug. 14, 2000.
  77. Schnell MA, Zhang Y, Tazelaar J, Gao G-P, Yu QC, Qian R, Chen S-J, Varnavski AN, LeClair C, Raper SE, Wilson JM. Activation of innate immunity in non-human primates following intra-portal administration of adenoviral vectors. Molecular Therapy 3(5 Pt 1):708-722, May 2001.
  78. Shifrin AL, Auricchio A, Yu Q-C, Wilson JM, Raper SE. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Therapy 8(19):1480-1489, Oct. 2001.
  79. Raper SE, Yudkoff M, Chirmule N, Gao G-P, Nunes F, Haskal ZJ, Furth EE, Propert K, Robinson MB, Magosin S, Simoes H, Speicher L, Hughes JV, Tazelaar J, Wivel NA, Wilson JM and Mark L. Batshaw ML A pilot study of in vivo liver directed gene transfer with an adenoviral vector in subjects with partial ornithine transcarbamylase deficiency. Human Gene Therapy 13(1):163-175, Jan. 1, 2002.
  80. Auricchio A, Gao GP, Yu QC, Raper SE, Rivera VM, Clackson T, Wilson JM. Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Therapy 9(14):963-971, July 2002.
  81. Raper SE. McClane SJ. Gene transfer strategies for metabolic diseases. World Journal of Surgery 26(7):838-842, July 2002.
  82. Deng S, Vatamaniuk M, Lian MM, Doliba N, Wang J, Bell E, Wolf B, Raper S, Matschinsky FM, Markmann JF. Insulin gene transfer enhances the function of human islet grafts. Diabetologia 46(3):386-393, Mar. 2003.
  83. Raper S, Lee F, Bagg A, Chirmule N, Wilson JM, Batshaw ML. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Molecular Genetics and Metabolism. 80(1-2):148-158, Sept./Oct. 2003.
  84. Kobinger GP, Deng S, Louboutin JP, Vatamaniuk M, Matschinsky F, Markmann JF, Raper , Wilson JM. Transduction of human islets with pseudotyped lentiviral vectors. Human Gene Therapy 15(2):211-219, Feb. 2004.
  85. Brinster D, Raper S. Synchronous colon and pancreatic cancers in a patient with Peutz-Jegher syndrome: Report of a case and review of the literature. Surgery 135(3):352-354, Mar. 2004.
  86. Phaneuf D, Moscioni AD, LeClair C, Raper SE, Wilson JM. Generation of a mouse expressing conditional knockout of the hepatocyte growth factor gene: Demonstration of impaired liver regeneration. DNA & Cell Biology 23(9):592-603, Sept. 2004.
  87. Sarwer DB, Cohn NI, Gibbons LM, Magee L, Crerand CE, Raper SE, Rosato EF, Williams NN, Wadden TA. Psychiatric diagnoses and psychiatric treatment among bariatric surgery candidates. Obesity Surgery 14(9):1148-1156, Oct. 2004.
  88. Kobinger GP, Deng S, Louboutin JP, Vatamaniuk M, Rivera VM, Lian MM, Markmann JF, Clackson T, Raper SE, Matschinsky F, Wilson JM. Pharmacologically regulated regeneration of functional human pancreatic islets.. Molecular Therapy 11(1):105-111, Jan. 2005.
  89. Shifrin AL, Chirmule N, Gao G-P, Wilson JM, Raper SE. Innate immune responses to adenoviral vector-mediated acute pancreatitis. Pancreas 30(2):122-129, Mar. 2005.
  90. Huang SY, Levine MS, Raper SE. Gastrocolic fistula with migration of feeding tube into transverse colon as a complication of percutaneous endoscopic gastrostomy. American Journal of Roentgenology 184(3 Suppl):S65-S66, Mar. 2005.
  91. Shifrin AL, Chirmule N, Gao G-P, Zhang Y, Raper SE. Macrophage ablation attenuates adenovi-ral mediated pancreatitis and prolongs transgene expression. Surgery 137(5):545-551, May 2005.
  92. Atluri P, Raper SE. Factor V Leiden and post-operative deep vein thrombosis in patients under-going open roux-en-Y gastric bypass surgery. Obesity Surgery 15(4):561-564, Apr. 2005.
  93. Gibbons LM, Sarwer DB, Canice E. Crerand CE, Fabricatore AN, Kuehnel RH, Lipschutz PE, Raper SE, Williams NN, Wadden TA. Previous weight loss experiences of bariatric surgery candidates: how much have patients dieted prior to surgery? Obesity Research 14(Suppl 2):70S-76S, Mar. 2006.
  94. Fabricatore AN, Wadden TA, Sarwer DB, Crerand CE, Kuehnel RH, Lipschutz P, Raper SE, Williams NW. Self-reported eating behaviors of extremely obese persons seeking bariatric surgery: a factor analytic approach. Obesity Research 14(Suppl 2):83S-89S, Mar. 2006.
  95. Wadden TA, Butryn ML, Sarwer DB, Fabricatore AN, Crerand CE, Lipschutz PE, Faulconbridge L, Raper SE, Williams NN. Comparison of psychosocial status in treatment-seeking women with Class III vs. Class I-II obesity. Obesity Research 14(Suppl 2):90S-98S, Mar. 2006.
  96. Moscioni D, Morizono H, McCarter RJ, Stern A, Cabrera-Luque J, Hoang A, Sanmiguel J, Wu D, Bell P, Gao GP, Raper SE, Wilson JM, Batshaw ML. Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with novel adeno-associated viral vectors. Molecular Therapy 14(1):25-33, July 2006 [Epub ahead of print].
  97. Bell P, Moscioni AD, McCarter RJ, Wu D, Gao G, Hoang A, Sanmiguel JC, Sun X, Wivel NA, Raper SE, Furth EE, Batshaw ML, Wilson JM. Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver. Molecular Therapy 14(1):34-44, July 2006 [Epub ahead of print].
  98. Wadden TA, Butryn ML, Sarwer DB, Fabricatore AN, Crerand CE, Lipschutz PE, Faulconbridge L, Raper S, Williams NN. Comparison of psychosocial status in treatment-seeking women with class III vs. class I-II obesity. Surgery for Obesity & Related Diseases 2(2):138-145, 2006.
  99. Fabricatore AN, Wadden TA, Sarwer DB, Crerand CE, Kuehnel RH, Lipschutz PE, Raper SE, Williams NN. Self-reported eating behaviors of extremely obese persons seeking bariatric surgery: A factor analytic approach. Surgery for Obesity & Related Diseases 2(2):146-152, Mar./Apr. 2006.
  100. Gibbons LM, Sarwer DB, Crerand CE, Fabricatore AN, Kuehnel RH, Lipschutz PE, Raper SE, Williams NN, Wadden TA. Previous weight loss experiences of bariatric surgery candidates: How much have patients dieted prior to surgery? Surgery for Obesity & Related Diseases 2(2):159-164; 2006.
  101. Gustafson TB, Gibbons LM, Sarwer DB, Crerand CE, Fabricatore AN, Wadden TA, Raper SE, Williams NN. History of sexual abuse among bariatric surgery candidates. Surgery for Obesity & Related Diseases 2(3):369-376; 2006.
  102. Kicska G, Levine MS, Raper SE, Williams NN. Gastric volvulus after laparoscopic adjustable gastric banding for morbid obesity. AJR Am J Roentgenol. 189(6):1469-72, 2007.
  103. Raper SE, Sarwer DB. Informed Consent Issues in the Conduct of Bariatric Surgery. Surgery for Obesity & Related Diseases. 4(1):60-8; 2008.
  104. Sarwer DB, Wadden TA, Moore RH, Baker AW, Gibbons LM, Raper SE, Williams NN. Preoperative eating behavior, postoperative dietary adherence, and weight loss after gastric bypass surgery. Surgery for Obesity & Related Diseases 2008 Jun 27 [Epub ahead of print].
  105. Sarwer DB, Wadden TA, Moore RH, Eisenberg MH, Raper SE, Williams NN. Changes in quality of life and body image after gastric bypass surgery. Surg Obes Relat Dis. 2010;6(6):608-14. PMCID: 3031862.
  106. Sareli AE, Cantor CR, Williams NN, Korus G, Raper SE, Pien G, Hurley S, Maislin G, Schwab RJ. Obstructive sleep apnea in patients undergoing bariatric surgery-a tertiary center experience. Obes. Surg. 2011;21(3):316-27.
  107. Dumon KR, Edelson PK, Raper SE, Foster-Kilgariff K, Williams NN. Implementation of designated bariatric surgery program leads to improved clinical outcomes. Surg Obes Relat Dis. 2011 May-Jun;7(3):271-6.
  108. Raper SE. No role for apology: remedial work and the problem of medical injury. Yale J Health Policy Law Ethics. 2011 Summer;11(2):267-330. No abstract available.
  109. Raper SE. One more piece of the puzzle? Adenosquamous carcinoma in a pancreatic mass. Gastroenterol Hepatol (N Y). 2011;7(9):630-2.
  110. Reinke CE, Drebin JA, Kreider S, Kean C, Resnick A, Raper SE, Kelz RR. Timing of Preoperative Pharmacoprophylaxis for Pancreatic Surgery Patients: A Venous Thromboembolism Reduction Initiative. Ann Surg Oncol. 2012; 19(1):19-25.
  111. Sarwer DB, Moore RH, Spitzer JC, Wadden TA, Raper SE, Williams NN. A pilot study investigating the efficacy of postoperative dietary counseling to improve outcomes after bariatric surgery. Surg Obes Relat Dis. 2012; 8(5):561-8
  112. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 62(1):102-11. (2013)
  113. Raper SE, Wilson, JM, Nunes FA. Flushing out Antibodies to Make AAV Gene Therapy Available to More Patients. Molecular Therapy. 21:269-72 (2013)
  114. Ullery BW, Wachtel H, Raper SE. Sister Mary Joseph's Nodule Presenting as Large Bowel Obstruction: A Case Report and Brief Review of the Literature. J Gastrointest Surg. 17:1832-85 (2013)
  115. Raper SE. Announcing Remedies for Medical Injury: A Proposal for Medical Liability Reform Based On the Patient Protection and Affordable Care Act. J of Health Care Law and Policy. 16:309-352 (2013)
Reviews in Peer-Reviewed Research Publications
  1. Eckhauser FE, Raper SE, Mulholland MW, Knol JA: Current concepts in the pathophysiology and treatment of portal hypertension and variceal hemorrhage. [Review] Gastroenteroligia Japonica 26(suppl 3):1-8, July 1991.
  2. Eckhauser FE, Raper SE, Knol JA, Mulholland MW: Surgical management of pancreatic pseudocysts, pancreatic ascites, and pancreaticopleural fistulas. [Review] Pancreas 6(Suppl 1):S66-S75, 1991.
  3. Raper SE, Wilson JM: Cell transplantation in liver directed gene therapy. [Review] Cell Transplantation 2(5):381-400, Sept./Oct. 1993.
  4. Raper SE. Hepatocyte transplantation and gene therapy. [Review] Clinical Transplantation 9(3 Pt 2):249-254, June 1995.
  5. Raper SE, Wilson JM. Gene therapy for human liver disease. [Review] Progress in Liver Diseases 13:201-30, 1995.
  6. Nunes FA, Raper SE. Liver-directed gene therapy. [Review] Medical Clinics of North America 80(5):1201-1213, Sept. 1996.
  7. Raper SE. Gene therapy: The good, the bad and the ugly. [Review] Surgery 137(5):487-492, May 2005.
  8. Raper SE. One more piece of the puzzle? Adenosquamous carcinoma in a pancreatic mass. [Commentary] Gastroenterol Hepatol (N Y). 2011; 7(9):630-2.
  9. Raper SE, Wilson, JM, Nunes FA. Flushing out Antibodies to Make AAV Gene Therapy Available to More Patients. Molecular Therapy. 21:269-72 (2013)
Research Publications, Non-Peer-Reviewed
  1. Eckhauser FE, Knol JA, Raper SE, Mulholland MW: A simplified and reliable method for transduodenal sphincteroplasty. Surgical Rounds 14(7):595-599, 1991.
  2. Raper SE, Eckhauser FE: Delayed gastric emptying after truncal vagotomy and gastrojejunos-tomy. Postgraduate General Surgery 4(3):214-216, 1992.
  3. Imanishi H, Kothary PC, Bhora F, Eckhauser F, Raper SE: TPA and vasopressin stimulate hepatic proliferation by PKC-dependent and -independent pathways. Surgical Forum 23:157-159, 1993.
  4. DeMatteo RD, Wilson JM, Raper SE: Optimization of pancreas-directed gene transfer in the rat. Surgical Forum 45:127-129, 1994.
  5. Min JK, Shaked A, Raper SE, Barker CF, Naji A. Adenoviral-mediated gene transfer of TGF-ß1 and vIL-10 promotes long-term survival of islet allografts. Surgical Forum 46:438-440, 1995.
  6. Hamilton TE, DeMatteo RP, Rombeau JL, Raper SE. A comparison of adenoviral and retro-viral gene transfer into the small intestine. Surgical Forum 46:649-650, 1995.
  7. Shifrin AL, Auricchio A, Wilson JM, Raper SE. Correction of hyperglycemia by expression of insulin gene in the pancreas with adenoviral vector. Surgical Forum 51:47-49; 2000.
Abstracts, Past 3 Years
  1. Raper SE, Resnick AS, Morris, JB. Disclosure of Adverse Outcomes: Developing a Course in Communication for Residents. Plenary talk, Surgical Education Week; Association of Program Directors in Surgery. Chicago, 4/9/2014
  2. Raper SE, Thornton J, Morris JB, Department of Surgery, University of Pennsylvania, LaMarra D, Perelman School of Medicine, University of Pennsylvania, Schueler J, Organizational Development & Leadership Practice, University of Pennsylvania Health System. Improving Communication Skills: A Course for Academic Medical Center Surgery Faculty. Poster of Distinction Surgical Education Week; Association of Program Directors in Surgery. Chicago, 4/10/2014
Editorials, Chapters and Participation in Committee Reports
  1. Way LW, Raper SE. Jaundice. Vol. I, Chap. 25 in Davis JH, Drucker WR, Foster RS Jr., Gamelli RL, Gann DS, Pruitt BA Jr., Sheldon GF (eds.): Clinical Surgery. St Louis: Mosby, 1987, 646-658.
  2. Eckhauser FE, Raper SE, Knol JA, Turcotte JG. Esophageal varices. Vol. I, Chap. 13 in Zuidema GD (ed.): Surgery of the Alimentary Tract, 3d Edition. Philadelphia: WB Saunders, 1991, 369-386.
  3. Knol JA, Raper SE, Eckhauser FE. Biliary fistulas. Vol. II, in Zuidema GD (ed.): Surgery of the Alimentary Tract, 4th Edition. Philadelphia: WB Saunders, 1995, 249-254.
  4. Eckhauser FE, Raper SE. Endoscopic treatment of esophageal varices and transjugular intrahepatic portosystemic shunts. In GD Zuidema (ed.): Surgery of the Alimentary Tract, 4th Edition. Philadelphia: WB Saunders, 1995, Volume III, 518-549.
  5. Eckhauser FE, Knol JA, Raper SE, Mulholland MW. Variceal ligation and gastroesophageal devascularization for variceal hemorrhage. In Stanley JC (ed.): Current Therapy in Vascular Surgery, 2nd Edition. St. Louis: Mosby/Year Book, 1991, 793-796.
  6. Barnett JL, Raper SE. Anorectal diseases. In Yamada T (ed.): Atlas of Gastroenterology. Philadelphia: JB Lippincott, 1991, 1813-1835.
  7. Eckhauser FE, Raper SE, Knol JA. Upper gastrointestinal bleeding. In Schwartz GR, Cayten CG, Mangelsen MA, Mayer TA, Hanke BK (eds.): Principles and Practice of Emergency Medicine, 3rd Edition. Philadelphia: Lea & Febiger, 1992, 1735-1744.
  8. Eckhauser FE, Raper SE. Diverticular disease of the small bowel. In Cameron JL (ed.): Current Surgical Therapy, 4th Edition. St. Louis: Mosby-Year Book, 1992, 123-127.
  9. Raper SE. Hepatic physiology. In Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB (eds.): Surgery: Scientific Principles and Practice. Philadelphia: JB Lippincott, 1992, 850-865.
  10. Turcotte JG, Raper SE, Eckhauser FE. Portal hypertension. In Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB (eds.): Surgery: Scientific Principles and Practice. Philadelphia: JB Lippincott, 1992, 887-908.
  11. Eckhauser FE, Raper SE, Mulholland MW, Knol JA. Carcinoma of the gallbladder. In Nieder-huber JE (ed.): Current Therapy in Oncology. St. Louis: Mosby-Year Book, 1993, 402-409.
  12. Raper SE. Hepatobiliary disease. In Bongard FS, Sue DY (eds.): Critical Care Diagnosis & Treatment. Norwalk, CT: Appleton & Lange, 1994, 576-591.
  13. Raper SE. Liver-directed gene therapy for metabolic disease. In Rosenberg S (ed.): Proceed-ings from the 1993 Surgical Research and Education Symposium, Volume 5: Gene Therapy in Surgery. Chicago: Surgical Research & Education Committee, American College of Surgeons, 1994, 25-36.
  14. Raper SE. Neoplastic disease of the small intestine. Chap. 33 in Bell RH, Rikkers L, Mulholland MW (eds.): Digestive Tract Surgery: A Text and Atlas. Philadelphia: JB Lippincott, 1996, 1189-1199.
  15. Raper SE, Wilson JM. Gene therapy for human liver disease. Vol. XIII, Chap. 8 in Boyer JL, Ockner RK (eds.): Progress in Liver Diseases. 1995, 201-230.
  16. Rader D, Raper SE, Wilson JM. Gene therapy for metabolic disease. Chap. 46 in LeRoith D, Taylor SI, Olefsky JM (eds.): Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott-Raven, 1996, 432-438.
  17. Raper SE. Human gene therapy. Chap. 15 in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds.): Surgery: Scientific Principles and Practice, 2nd Edition. Philadelphia: JB Lippincott, 1997, 506-527.
  18. Turcotte JG, Raper SE, Eckhauser FE. Cirrhosis and portal hypertension. Chap. 38 in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds.): Surgery: Scientific Principles and Practice, 2nd Edition. Philadelphia: JB Lippincott, 1997, 972-1008.
  19. Raper SE, Wilson JM. Making space for intestinal gene therapy. [Commentary/Editorial] Gastroenterology 112(5):1753-1756, May 1997.
  20. McClane SJ, Raper SE. Liver directed gene therapy. Chap. 20 in Mito M, Sawa M (eds.): Hepatocyte Transplantation. Basel, Switzerland: Karger Landes Systems, 1997, 255-283.
  21. Raper SE, Moscioni AD. Ex vivo hepatocyte-directed gene therapy. Chap. 29 in Berry MN, Edwards AM (eds.): The Hepatocyte Review. Dordrecth, the Netherlands: Kluwer Academic Publishers, 2000, 503-520.
  22. Raper SE. Hepatic physiology. Chap. 35 in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds.): Surgery: Scientific Principles and Practice, 3rd Edition. Philadelphia: JB Lippincott, 2001, 927-943.
  23. Ra J-H, Raper SE. The small bowel. Chap. 13 in Atluri P, Karakousis G, Porrett P, Kaiser LR (eds.): The Surgical Review, Second Edition. Philadelphia: Lippincott Williams & Wilkins, 2005, 187-201.
  24. Raper SE. Substrate metabolism in surgery. Chap. 2 in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds.): Surgery: Scientific Principles and Practice, 4h Edition. Philadelphia: JB Lippincott, 2006, 42-52.
  25. Merianos D, Raper SE. Inguinal Hernia Repair. In Gowned and Gloved Surgery. Roses RE, Paulson EC, Kanchawala S, Morris JB eds. Philadelphia, PA. Saunders Elsevier, 2009.
  26. Ra J-H, Raper SE. Chap. 11 The small bowel. in Porrett P, Frederick JR, Roses R, Kaiser LR (eds.): The Surgical Review, Third Edition. Philadelphia: Lippincott Williams & Wilkins, 2010, 121-135.
  27. Raper SE. Chapter 6: Informed Consent. in Morbid Obesity: Perioperative Management; Second Edition. Alvarez A, Brodsky JB, Lemmens HJM, Morton JM. (eds). Cambridge University Press, Cambridge UK. 2010.
  28. Raper SE. Chap. 2 Substrate metabolism in surgery. in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds.): Surgery: Scientific Principles and Practice,5h Edition. Philadelphia: JB Lippincott, 2010.
Books
  1. Andersen DA, Raper SE, Messina L, Economou JS (eds.). Master Series in Surgery, Volume VI: Advances in Surgical Gene Therapy. Cedar Knolls, NJ: World Medical Press, 1995.
 
Awards, Honors and Membership in Honorary Societies
2012 Penn Medicine Patient Advocacy Award
 
1999 Master of Arts, Honorary, University of Pennsylvania
 
1988 - 1990 Society for Surgery of the Alimentary Tract Career Development Award
 
1987 Nusz Award for Outstanding Chief Resident
 
1984 American Liver Foundation Research Fellowship
 
1979  Alpha Omega Alpha, Alpha Chapter

Dr. Steven Raper

 
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