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Abraham Shaked, M.D., Ph.D.
Transplant Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street, 2 Dulles
Philadelphia, PA 19104
Administrative Coordinator: Kathy Kratowicz
Administrative Telephone: 215-662-6723
Administrative Fax: 215-662-2244
Patient Appointments for Hepatobiliary Surgery: 215-662-6723

Clinical Office:
Perelman Center for Advanced Medicine
West Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-662-6200
Clinical Fax: 215-662-2244
Patient Appointments for Transplant Evaluation: 215-662-6200

Contact Information (internal use only)

 

Abraham Shaked, MD, PhD, is the Eldrige L. Eliason Professor of Surgery, and Director of the Penn Transplant Institute. Dr. Shaked received his MD degree from the Hebrew University in Israel and completed his general surgery training at Mount Sinai Hospital in New York, where he also accomplished a degree of Doctor of Philosophy in molecular pathology and immunology.  He then completed an accredited transplantation fellowship at the University of California, Los Angeles (UCLA), where he served for 5 years as the Associate Director of the busiest liver transplant program in the country. In 1995 Dr. Shaked was recruited to lead the liver transplant program at the University of Pennsylvania and the Children's Hospital of Philadelphia.  Since then the combined program has become one of the 10 busiest in the country. His clinical activity is focused in adult and pediatric liver transplantation, complex hepatobiliary surgery, biliary reconstruction, and minimization of immunosuppression.

Dr. Shaked is a nationally and internationally recognized leader in the field of transplantation and served as President of the American Society of Transplant Surgeons. Dr. Shaked's academic record is reflected by his outstanding achievements in basic laboratory research, translational research, and support for clinical science investigation.  His laboratory efforts focus on the exploration of early gene expression in organ donors and using molecular identifiers to determine the relationship of proinflammation and the activation of the alloimmune response.  These studies are extended to determine biomarkers of rejection in blood and urine of organ recipients.  He is supported by continuous NIH funding since 1992.  He has published over 150 manuscripts, and is a member of the Editorial boards of American Journal of Transplantation, Transplantation, and Liver Transplantation.

 
Faculty Appointments
2005 - present Eldridge L. Eliason Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2001 - 2005 Fred and Suzanne Biesecker
Professor of Surgery; Endowed Chair
The Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2001 - present Director, Fred and Suzanne Biesecker
Pediatric Liver Center
The Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
1998 - present Professor of Surgery (with Tenure)
University of Pennsylvania
Philadelphia, Pennsylvania
 
1995 - 1998 Associate Professor of Surgery
University of Pennsylvania,
Philadelphia, Pennsylvania
 
1993 - 1995 Associate Professor of Surgery
UCLA School of Medicine
Los Angeles, California
 
1990 - 1993 Assistant Professor of Surgery
UCLA School of Medicine
Los Angeles, California
 
1988 - 1989 Instructor in Surgery
Mount Sinai Medical Center
New York, New York
 
Hospital and Administrative Appointments
2008 - present Chair, NIH/NAIDD CTOT Steering Committee
 
2006 - present Director, PENN Transplant Institute
University of Pennsylvania School of Medicine
 
2005 - 2006 Board of Directors
United Network Organ Sharing (UNOS)
 
2001 - 2005 Director, Fred and Suzanne Biesecker Pediatric Liver Center
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2001 - 2006 Director, PENN Transplant Center
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2001 - 2013 Chief, Division of Transplantation Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
1999 - 2001 Medical Advisory Committee
Liver/Small Bowel Subcommittee
United Network Organ Sharing (UNOS)
 
1996 - 1998 Regional Representative,
United Network Organ Sharing (UNOS)
 
1995 - 2004 Board of Directors
(Delaware Valley Transplant Program)
 
1995 - 1999 Chief, Liver Transplant,
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
1995 - 2004 Chief, Liver Transplant,
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1995 - present University Associate Level 1
The Children's Hospital of Philadelphia
 
1990 -1995 Associate Director, Dumont-UCLA Transplant Center
Los Angeles, California
 
1990 - 1995 Attending Surgeon, Department of Surgery
Division of General Surgery
UCLA Medical Center
Los Angeles, California
 
Education/Training
1982 M.D., Hebrew University-Hadassah School of Medicine
Jerusalem, Israel
 
1989

Ph.D., Molecular and Cellular Pathology/Immunology Biomedical Sciences Program
City University of New York, New York, New York

 
Postgraduate Training and Fellowship Appointments
1981 - 1982 Resident (Post Graduate Year I, II)
Department of Surgery
 
1983 - 1984 Hadassah University Hospital
Jerusalem, Israel
 
1984 - 1987 Ph.D., Candidate
Biomedical Sciences Doctoral Program
Mount Sinai School of Medicine; New York, New York
Advisor: Lloyd Mayer, M.D.
Division of Clinical Immunology, Department of Medicine
 
1982 - 1983
1986 - 1988
Resident (Post Graduate Years III, IV, V)
Department of Surgery, Mount Sinai Medical Center
New York, New York
 
1988 - 1989 Chief Resident (Post Graduate Year VI)
Department of Surgery, Mount Sinai Medical Center
New York City, New York
 
1989 - 1990 Fellow Liver Transplantation Program
Division of General Surgery, UCLA Medical Center
Los Angeles, California
 
Memberships/Societies
 
International
  • 2002-present International Pediatric Transplant Society
  • 2006-present International Liver Transplant Society
 
National Societies
  • 1991-present American Society of Transplant Surgeons
    • Chairman, Program and Publication Committee, 1996-1999
    • Secretary 1999-2002
    • President-Elect 2002-2003
    • President 2003-2004
    • President, Foundation 2004-2005
  • 1992-present American College of Surgeons (Fellow)
  • 1993 NIH Advisory Board - Transplantation Genomic Workshop
  • 1993-present Society of University Surgeons
  • 1999-present American Surgical Association
  • 1999-2004 Association for Academic Surgery
  • 2000-present American Association for the Study of Liver Disease
  • 2002-present Transplantation Society
  • 2003-2008 NIH Advisory Board, Steering Committee - CCTPT
  • 2004-present NIH/NIAID CTOT Steering Committee
  • 2005 NIH Advisory Board, Action Plan for Transplantation
  • 2005-Present NIH Special Emphasis Panels
  • 2005-present Surgical Biology Club II
  • 2006 NIH Advisory Board, Immune Tolerance and Organ Transplantation
  • 2007-Present NIH Special Emphasis Panels
 
National Scientific Committees
  • United Network Organ Sharing (Regional Representative, 1996-1998)
 
Local/Regional Scientific Committees
  • The Transplantation Society
 
Research
Dr. Shaked current studies are focused on human immunological monitoring in the transplant setting.
  1. We are using gene expression profiling for the characterization of innate immunity and adaptive immunity pertinent to solid organ transplantation.
    In renal allograft recipients, we will investigating whether: (a) acute rejection can be predicted by sequential mRNA profiling of urinary cells; (b) preemptive treatment, based on mRNA profiles, prevents acute rejection and preserves GFR, and (c) mRNA profiles can be used to guide immunosuppression management, such as the withdrawal of calcineurin inhibitors in stable recipients.

    Studies in diverse groups of transplanted organs are centered on the molecular profiling of organ specific and non-specific injury pathways in the donor prior to procurement and in the recipient immediately after transplantation, and their impact on organ function and alloreactivity.

  2. Liver tolerance in the setting of HCV infection:
    It is possible that tolerance induction may be occurring in a significant number of liver transplant recipients already as a result of variables intrinsic to the organ. In these individuals, tolerance was achieved either after abrupt discontinuation of immunosuppression, or following gradual weaning of immunosuppression long after transplantation. Importantly, the occurrence of rejection during weaning was reversed by reinstitution of immunosuppression, and did not result in a significant long-term damage to the graft. The current study is focused on recipients undergoing OLT for CAHC. The aims are to determine whether HCV infected individuals who become tolerant express immune and genetic profiles that are similar to non-HCV infected recipients, and if immunosuppression withdrawal at a later stage has favorable impact on the severity of HCV recurrence and injury to the transplanted graft.
  3. Immune response in the setting of Living Donor Liver Transplantation (LDLT):
    LDLT and cadaveric transplantation are associated with differential pathways of inflammatory response and immune activation, resulting in development of a distinct state of tolerance to the allograft.
    1. Regeneration may be associated with different pattern of lymphocyte trafficking in and out the graft resulting in a differential repopulation of the liver with donor cells, and unknown effects on the extent of peripheral chimerism.
    1. Transplantation of a lobe from a living donor is done under conditions allowing extremely short cold ischemic time, a variable that may affect the severity of the inflammatory and immune response.
      We are investigating whether this phenomenon would be reflected in the frequency of episodes of acute or chronic rejection, and the appearance of peripheral and intragraft molecular and cellular profiles that are indicative of donor-specific alloresponsiveness.
 
Publications, peer reviewed (print or other media)
  1. Gomori, J M.  Shaked, A.: Radiation induced meningiomas. Neuroradiology 23(4): 211-2, 1982.
  2. Shaked, A.  Raz, I.  Gottehrer, A.  Romanoff, H.: Roentgenogram of the month. Asymptomatic, highly vascularized superior mediastinal mass. Chest 86(4): 621-2, Oct 1984.
  3. Gordon, R E.  Shaked, A A.  Solano, D F.: Taurine protects hamster bronchioles from acute NO2-induced alterations. A histologic, ultrastructural, and freeze-fracture study. American Journal of Pathology 125(3): 585-600, Dec 1986.
  4. Shaked, A.  Sherris, D.  Mayer, L.: Isolation of fibroblast proliferation factor: distinction from interleukin-1. Current Surgery 44(6): 487-90, Nov-Dec 1987.
  5. Sperber, K.  Shaked, A.  Posnett, D N.  Hirschman, S Z.  Bekesi, G.  Mayer, L.: Surface expression of CD-4 does not predict susceptibility to infection with HIV-1 in human monocyte hybridomas. Journal of Clinical & Laboratory Immunology 31(4): 151-6, Apr 1990.
  6. Shaked, A A.  Busuttil, R W.: Auxiliary liver transplantation: a negative viewpoint. Hepatology 12(1): 173-5, Jul 1990.
  7. Shaked, A.  Calderom, I.  Durst, A.: Safety of surgical procedures performed by residents. Archives of Surgery 126(5): 559-60, May 1991.
  8. Shaked, A.  Larrick, J.  Fotino, M.  Mayer, L.: The generation and characterization of human monocyte hybridomas. Journal of Immunological Methods 140(1): 45-55, Jun 24 1991.
  9. Binderow, S R.  Shaked, A A.: Acute appendicitis in patients with AIDS/HIV infection. American Journal of Surgery 162(1): 9-12, Jul 1991.
  10. Shaked, A A.  Takiff, H.  Busuttil, R W.: The use of the supraceliac aorta for hepatic arterial revascularization in transplantation of the liver. Surgery, Gynecology & Obstetrics 173(3): 198-202, Sep 1991.
  11. Imagawa, D K.  Strange, S M.  Shaked, A.  Seu, P.  Colonna, J O.  Farmer, D.  McDiramid, S V.  Morrissey, M P.  Busuttil, R W.: Liver transplantation at UCLA: report of clinical activities. Clinical Transplants Page: 127-34, 1991.
  12. Seu, P.  Wilkinson, A H.  Shaked, A.  Busuttil, R W.: The hepatorenal syndrome in liver transplant recipients. American Surgeon 57(12): 806-9, Dec 1991.
  13. Shaked, A.  Busuttil, R W.: Liver transplantation in patients with portal vein thrombosis and central portacaval shunts. Annals of Surgery 214(6): 696-702, Dec 1991.
  14. Shaked, A.  Sperber, K.  Mayer, L.: Stimulation of distinct T cell subsets in MLR using human macrophage hybridomas differentially expressing class II antigens. Transplantation 52(6): 1068-72, Dec 1991.
  15. Shaked, A.  McDiarmid, S V.  Harrison, R E.  Gelebert, H A.  Colonna, J O 3rd.  Busuttil, R W.: Hepatic artery thrombosis resulting in gas gangrene of the transplanted liver. Surgery 111(4): 462-5, Apr 1992.
  16. Konishi, Y.  Shaked, A.  Egawa, H.  Busuttil, R W.  Ozawa, K.: Correlation of hepatic injury, synthetic function, and mitochondria energy level in orthotopic liver transplantation. Journal of Surgical Research 52(5): 466-71, May 1992.
  17. Shaked, A.  Colonna, J O.  Goldstein, L.  Busuttil, R W.: The interrelation between sclerosing cholangitis and ulcerative colitis in patients undergoing liver transplantation. Annals of Surgery 215(6): 598-603; discussion 604-5, Jun 1992.
  18. Shaked, A.  Goldstein, R M.  Klintmalm, G B.  Drazan, K.  Husberg, B.  Busuttil, R W.: Portosystemic shunt versus orthotopic liver transplantation for the Budd-Chiari syndrome. Surgery, Gynecology & Obstetrics 174(6): 453-9, Jun 1992.
  19. Shaked, A.  Hoyos, B.  Mayer, L.: The role of differential class II antigen expression in stimulation of allogeneic mixed lymphocyte reactions by human monocyte hybridomas. Transplantation 53(6): 1341-7, Jun 1992.
  20. Umeshita, K.  Monden, M.  Tono, T.  Hasuike, Y.  Kanai, T.  Gotoh, M.  Mori, T.  Seu, P.  Shaked, A.  Busuttil, R W.: Interleukin-6 in bile as a marker of allograft rejection following liver transplantation in man. Transplantation Proceedings 24(4): 1462-4, Aug 1992.
  21. Colonna, J O 2nd.  Shaked, A.  Gomes, A S.  Colquhoun, S D.  Jurim, O.  McDiarmid, S V.  Millis, J M.  Goldstein, L I.  Busuttil, R W.: Biliary strictures complicating liver transplantation. Incidence, pathogenesis, management, and outcome. Annals of Surgery 216(3): 344-50; discussion 350-2, Sep 1992.
  22. Busuttil, R W.  Farmer, D G.  Shaked, A.  Rolandelli, R.  Colonna, J O 2nd.  Jurim, O.  Colquhoun, S D.  Bernstein, C.  Shanahan, F.  Robert, M.  et al.: Successful combined liver and small intestine transplantation for short-gut syndrome and liver failure. [Review] [17 refs] Western Journal of Medicine 158(2): 184-8, Feb 1993.
  23. Hasuike, Y.  Shaked, A.  Monden, M.  Shiraishi, M.  Farmer, D.  Holly, E G.  Busuttil, R W.: Selective mesenteric lymphoid irradiation eliminates the effector cells of lethal graft-versus-host disease while protecting radiosensitive intestinal tissue. Transplantation Proceedings 25(1 Pt 2): 1196-7, Feb 1993.
  24. Shiraishi, M.  Shaked, A.  Yasunaga, C.  Hasuike, Y.  Imagawa, D K.  Busuttil, R W.: Monoclonal anti-tumor necrosis factor-alpha antibody suppresses rejection, but enhances infectious complications in rat liver allograft recipients. Transplantation Proceedings 25(1 Pt 1): 128-9, Feb 1993.
  25. Egawa, H.  Shaked, A.  Konishi, Y.  McDiarmid, S V.  Vargas, J.  Shimahara, Y.  Colonna, J.  Mori, K.  Yamamoto, N.  Ozawa, K.  et al.: Arterial ketone body ratio in pediatric liver transplantation. Transplantation 55(3): 522-6, Mar 1993.
  26. Colonna, J O 2nd.  Shaked, A.  Gelabert, H A.  Busuttil, R W.: Resection of the caudate lobe through "bloody gultch". Surgery, Gynecology & Obstetrics 176(4): 401-2, Apr 1993.
  27. McDiarmid, S V.  Colonna, J O 2nd.  Shaked, A.  Vargas, J.  Ament, M E.  Busuttil, R W.: Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. Transplantation 55(6): 1328-32, Jun 1993.
  28. Jurim, O.  Shaked, A.  Kiai, K.  Millis, J M.  Colquhoun, S D.  Busuttil, R W.: Celiac compression syndrome and liver transplantation. Annals of Surgery 218(1): 10-2, Jul 1993.
  29. Sherman, S.  Shaked, A.  Cryer, H M.  Goldstein, L I.  Busuttil, R W.: Endoscopic management of biliary fistulas complicating liver transplantation and other hepatobiliary operations. Annals of Surgery 218(2): 167-75, Aug 1993.
  30. Shaked, A.  Thompson, M.  Wilkinson, A H.  Nuesse, B.  el-Khoury, G F.  Rosenthal, J T.  Danovich, G M.  Busuttil, R W.: The role of combined liver/kidney transplantation in end-stage hepato-renal disease. American Surgeon 59(9): 606-9, Sep 1993.
  31. Shaked, A.  Vargas, J.  Csete, M E.  Kiai, K.  Jurim, O.  Colquhoun, S.  McDiarmid, S V.  Ament, M E.  Busuttil, R W.: Diagnosis and treatment of bowel perforation following pediatric orthotopic liver transplantation. Archives of Surgery 128(9): 994-8; discussion 998-9, Sep 1993.
  32. McDiarmid, S V.  Colonna, J O 2nd.  Shaked, A.  Ament, M E.  Busuttil, R W.: A comparison of renal function in cyclosporine- and FK-506-treated patients after primary orthotopic liver transplantation. Transplantation 56(4): 847-53, Oct 1993.
  33. Csete, M.  Neelakanta, G.  Shaked, A.  Busuttil, R W.: Prolonged venovenous bypass for intraoperative failure of transplanted livers--a report of three cases. Transplantation 56(5): 1290-2, Nov 1993.
  34. Colquhoun, S D.  Shaked, A.  Jurim, O.  Colonna, J O.  Rosove, M H.  Busuttil, R W.: Reversal of neutropenia with granulocyte colony-stimulating factor without precipitating liver allograft rejection.[Republished from Transplantation 1993 Sep;56(3):755-8] Transplantation 56(6): 1593-5, Dec 1993.
  35. Farmer, D G.  Shaked, A.  Colonna, J O 2nd.  Olthoff, K M.  Jurim, O.  Colquhoun, S.  Millis, J M.  Busuttil, R W.: Radical resection combined with liver transplantation for foregut tumors. [Review] [34 refs] American Surgeon 59(12): 806-12, Dec 1993.
  36. Shaked, A.  Csete, M E.  Shiraishi, M.  Miller, A R.  Moen, R C.  Busuttil, R W.  Economou, J S.: Retroviral-mediated gene transfer into rat experimental liver transplant. Transplantation 57(1): 32-4, Jan 1994.
  37. Jurim, O.  Gelabert, H A.  Shaked, A.  Nuesse, B J.  McDiarmid, S V.  Busuttil, R W.: Reduced graft OLT for emergency indications in pediatric patients. Transplantation Proceedings 26(1): 195, Feb 1994.
  38. Karademir, S.  Csete, M E.  Jurim, O.  Finstad, T.  Hawkins, R.  Bussuttil, R W.  Shaked, A.: Role of 99mTc-labeled DISIDA scan in the assessment of marginal liver grafts after orthotopic transplantation. Clinical Transplantation 8(1): 54-8, Feb 1994.
  39. Shiraishi, M.  Csete, M E.  Yasunaga, C.  Drazan, K E.  Jurim, O.  Cramer, D V.  Busuttil, R W.  Shaked, A.: Regeneration-induced accelerated rejection in reduced-size liver grafts. Transplantation 57(3): 336-40, Feb 1994.
  40. Colquhoun, S D.  Robert, M E.  Shaked, A.  Rosenthal, J T.  Millis, T M.  Farmer, D G.  Jurim, O.  Busuttil, R W.: Transmission of CNS malignancy by organ transplantation. Transplantation 57(6): 970-4, Mar 27 1994.
  41. Farmer, D G.  Rosove, M H.  Shaked, A.  Busuttil, R W.: Current treatment modalities for hepatocellular carcinoma. [Review] [84 refs] Annals of Surgery 219(3): 236-47, Mar 1994.
  42. Csete, M E.  Afra, R.  Mullen, Y.  Drazan, K E.  Benhamou, P Y.  Shaked, A.: Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function. Transplantation Proceedings 26(2): 756-7, Apr 1994.
  43. Jurim, O.  Shaked, A.  Rose, S.  Busuttil, R.: Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. International Surgery 79(2): 176-7, Apr-Jun 1994.
  44. Busuttil, R W.  Shaked, A.  Millis, J M.  Jurim, O.  Colquhoun, S D.  Shackleton, C R.  Nuesse, B J.  Csete, M.  Goldstein, L I.  McDiarmid, S V.: One thousand liver transplants. The lessons learned. Annals of Surgery 219(5): 490-7; discussion 498-9, May 1994.
  45. Csete, M E.  Drazan, K E.  van Bree, M.  McIntee, D F.  McBride, W H.  Bett, A.  Graham, F L.  Busuttil, R W.  Berk, A J.  Shaked, A.: Adenovirus-mediated gene transfer in the transplant setting. I. Conditions for expression of transferred genes in cold-preserved hepatocytes. Transplantation 57(10): 1502-7, May 27 1994.
  46. Jurim, O.  Colonna, J O 2nd.  Colquhoun, S D.  Shaked, A.  Busuttil, R W.: A stapling technique for hepatic resection. Journal of the American College of Surgeons 178(5): 510-1, May 1994.
  47. Jurim, O.  Martin, P.  Shaked, A.  Goldstein, L.  Millis, J M.  Calquhoun, S D.  Gitnick, G.  Tong, M J.  Busuttil, R W.: Liver transplantation for chronic hepatitis B in Asians. Transplantation 57(9): 1393-5, May 15 1994.
  48. Shaked, A.  Csete, M E.  Drazan, K E.  Bullington, D.  Wu, L.  Busuttil, R W.  Berk, A J.: Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts. Transplantation 57(10): 1508-11, May 27 1994.
  49. McDiarmid, S V.  Farmer, D G.  Kuniyoshi, J S.  Robert, M.  Khadavi, A.  Shaked, A.  Busuttil, R W.: Intragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression as predictors of rat small intestine transplant rejection. Transplantation Proceedings 26(3): 1520-1, Jun 1994.
  50. Farmer, D G.  McDiarmid, S V.  Kuniyoshi, J.  Robert, M E.  Shaked, A.  Busuttil, R W.: Intragraft expression of messenger RNA for interleukin-6 and tumor necrosis factor-alpha is a predictor of rat small intestine transplant rejection. Journal of Surgical Research 57(1): 138-42, Jul 1994.
  51. Drazan, K E.  Shen, X D.  Csete, M E.  Zhang, W W.  Roth, J A.  Busuttil, R W.  Shaked, A.: In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection. Surgery 116(2): 197-203; discussion 203-4, Aug 1994.
  52. Morris, B D Jr.  Drazan, K E.  Csete, M E.  Werthman, P E.  Van Bree, M P.  Rosenthal, J T.  Shaked, A.: Adenoviral-mediated gene transfer to bladder in vivo. Journal of Urology 152(2 Pt 1): 506-9, Aug 1994.
  53. Lo, C M.  Shaked, A.  Busuttil, R W.: Risk factors for liver transplantation across the ABO barrier. Transplantation 58(5): 543-7, Sep 15 1994.
  54. McDiarmid, S V.  Farmer, D G.  Kuniyoshi, J S.  Robert, M.  Khadavi, A.  Shaked, A.  Busuttil, R W.: The correlation of intragraft cytokine expression with rejection in rat small intestine transplantation. Transplantation 58(6): 690-7, Sep 27 1994.
  55. Dawson, S 3rd.  Imagawa, D K.  Cecka, J M.  Gjertson, D W.  Shackleton, C M.  Shaked, A.  Busuttil, R.: UCLA liver transplantation: analysis of the first 1,000 patients. Clinical Transplants Page: 189-95, 1994.
  56. Csete, M E.  Benhamou, P Y.  Drazan, K E.  Wu, L.  McIntee, D F.  Afra, R.  Mullen, Y.  Busuttil, R W.  Shaked, A.: Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation 59(2): 263-8, Jan 27 1995.
  57. Jurim, O.  Csete, M.  Gelabert, H A.  Millis, J M.  Olthoff, K.  Imagawa, D.  Shaked, A.  McDiarmid, S V.  Busuttil, R W.: Reduced-size grafts--the solution for hepatic artery thrombosis after pediatric liver transplantation?. Journal of Pediatric Surgery 30(1): 53-5, Jan 1995.
  58. Drazan, K E.  Shen, X D.  Wu, L.  Jurim, O.  Busuttil, R W.  Shaked, A.: Adenoviral-mediated gene transfer to liver xenografts results in successful expression and protein production. Transplantation Proceedings 27(1): 331-2, Feb 1995.
  59. Lo, C M.  Shaked, A.  Drazan, K.  Yersiz, H.  Jurim, O.  Busuttil, R.: Variables affecting transplantation across ABO blood groups. Transplantation Proceedings 27(1): 1159, Feb 1995.
  60. Millis, M.  Imagawa, D.  Olthoff, K.  Martin, P.  Gomes, A.  Shaked, A.  Yersiz, H.  Drazan, K.  Jurim, O.  Goldstein, L.  et al.: TIPS: impact on liver transplantation. Transplantation Proceedings 27(1): 1252-3, Feb 1995.
  61. Drazan, K E.  Wu, L.  Shen, X D.  Bullington, D.  Jurim, O.  Busuttil, R W.  Shaked, A.: Adenovirus-mediated gene transfer in the transplant setting. Part III. Variables affecting gene transfer in liver grafts. Transplantation 59(5): 670-3, Mar 15 1995.
  62. McDiarmid, S V.  Farmer, D G.  Kuniyoshi, J S.  Robert, M.  Khadavi, A.  Shaked, A.  Busuttil, R W.: Perforin and granzyme B. Cytolytic proteins up-regulated during rejection of rat small intestine allografts. Transplantation 59(5): 762-6, Mar 15 1995.
  63. Qin, L.  Chavin, K D.  Ding, Y.  Favaro, J P.  Woodward, J E.  Lin, J.  Tahara, H.  Robbins, P.  Shaked, A.  Ho, D Y.  et al.: Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10. Transplantation 59(6): 809-16, Mar 27 1995.
  64. Jurim, O.  Shackleton, C R.  McDiarmid, S V.  Martin, P.  Shaked, A.  Millis, J M.  Imagawa, D K.  Olthoff, K M.  Maxfield, A.  Pakrasi, A L.  et al.: Living-donor liver transplantation at UCLA. American Journal of Surgery 169(5): 529-32, May 1995.
  65. Shiraishi, M.  Csete, M.  Yasunaga, C.  McDiarmid, S V.  Vannice, J L.  Busuttil, R W.  Shaked, A.: The inhibitor cytokine interleukin-1 receptor antagonist synergistically augments cyclosporine immunosuppression in a rat cardiac allograft model. Journal of Surgical Research 58(5): 465-70, May 1995.
  66. Badie, B.  Drazan, K E.  Kramar, M H.  Shaked, A.  Black, K L.: Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats. Neurological Research 17(3): 209-16, Jun 1995.
  67. Olthoff, K M.  Rosove, M H.  Shackleton, C R.  Imagawa, D K.  Farmer, D G.  Northcross, P.  Pakrasi, A L.  Martin, P.  Goldstein, L I.  Shaked, A.  et al.: Adjuvant chemotherapy improves survival after liver transplantation for hepatocellular carcinoma. [Review] [23 refs][Erratum appears in Ann Surg 1996 Nov;224(5):686] Annals of Surgery 221(6): 734-41; discussion 731-43, Jun 1995.
  68. Drazan, K E.  Wu, L.  Olthoff, K M.  Jurim, O.  Busuttil, R W.  Shaked, A.: Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. Journal of Surgical Research 59(1): 219-23, Jul 1995.
  69. Farmer, D G.  Shaked, A.  Olthoff, K M.  Imagawa, D K.  Millis, J M.  Busuttil, R W.: Evaluation, operative management, and outcome after liver transplantation in children with biliary atresia and situs inversus. Annals of Surgery 222(1): 47-50, Jul 1995.
  70. Millis, J M.  Martin, P.  Gomes, A.  Shaked, A.  Colquhoun, S D.  Jurim, O.  Goldstein, L.  Busuttil, R W.: Transjugular intrahepatic portosystemic shunts: impact on liver transplantation. Liver Transplantation & Surgery 1(4): 229-33, Jul 1995.
  71. Winston, D J.  Wirin, D.  Shaked, A.  Busuttil, R W.: Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. Lancet 346(8967): 69-74, Jul 8 1995.
  72. Drazan, K E.  Csete, M E.  Da Shen, X.  Bullington, D.  Cottle, G.  Busuttil, R W.  Shaked, A.: Hepatic function is preserved following liver-directed, adenovirus-mediated gene transfer. Journal of Surgical Research 59(2): 299-304, Aug 1995.
  73. Sherman, S.  Jamidar, P.  Shaked, A.  Kendall, B J.  Goldstein, L I.  Busuttil, R W.: Biliary tract complications after orthotopic liver transplantation. Endoscopic approach to diagnosis and therapy. Transplantation 60(5): 467-70, Sep 15 1995.
  74. Yersiz, H.  Shaked, A.  Olthoff, K.  Imagawa, D.  Shackleton, C.  Martin, P.  Busuttil, R W.: Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation 60(8): 790-4, Oct 27 1995.
  75. Winston, D J.  Imagawa, D K.  Holt, C D.  Kaldas, F.  Shaked, A.  Busuttil, R W.: Long-term ganciclovir prophylaxis eliminates serious cytomegalovirus disease in liver transplant recipients receiving OKT3 therapy for rejection. Transplantation 60(11): 1357-60, Dec 15 1995.
  76. Umeshita, K.  Monden, M.  Tono, T.  Hasuike, Y.  Kanai, T.  Gotoh, M.  Mori, T.  Shaked, A.  Busuttil, R W.: Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation. Its role in the diagnosis of acute rejection. Annals of Surgery 223(2): 204-11, Feb 1996.
  77. Werthman, P E.  Drazan, K E.  Rosenthal, J T.  Khalili, R.  Shaked, A.: Adenoviral-p53 gene transfer to orthotopic and peritoneal murine bladder cancer. Journal of Urology 155(2): 753-6, Feb 1996.
  78. Drazan, K E.  Wu, L.  Bullington, D.  Shaked, A.: Viral IL-10 gene therapy inhibits TNF-alpha and IL-1 beta, not IL-6, in the newborn endotoxemic mouse. Journal of Pediatric Surgery 31(3): 411-4, Mar 1996.
  79. Drazan, K.  Shaked, A.  Olthoff, K M.  Imagawa, D.  Jurim, O.  Kiai, K.  Shackelton, C.  Busuttil, R.: Etiology and management of symptomatic adult hepatic artery thrombosis after orthotopic liver transplantation (OLT). American Surgeon 62(3): 237-40, Mar 1996.
  80. Imagawa, D K.  Olthoff, K M.  Yersiz, H.  Shackleton, C R.  Colquhoun, S D.  Shaked, A.  Busuttil, R W.: Rapid en bloc technique for pancreas-liver procurement. Improved early liver function. Transplantation 61(11): 1605-9, Jun 15 1996.
  81. Seu, P.  Shackleton, C R.  Shaked, A.  Imagawa, D K.  Olthoff, K M.  Rudich, S R.  Kinkhabwala, M.  Busuttil, R W.: Improved results of liver transplantation in patients with portal vein thrombosis. Archives of Surgery 131(8): 840-4; discussion 844-5, Aug 1996.
  82. Jurim, O.  Martin, P.  Winston, D J.  Shackleton, C.  Holt, C.  Feller, J.  Csete, M.  Shaked, A.  Imagawa, D.  Olthoff, K.  Lau, J Y.  Busuttil, R W.: Failure of ganciclovir prophylaxis to prevent allograft reinfection following orthotopic liver transplantation for chronic hepatitis B infection. Liver Transplantation & Surgery 2(5): 370-4, Sep 1996.
  83. Drazan, K E.  Olthoff, K M.  Wu, L.  Shen, X D.  Gelman, A.  Shaked, A.: Adenovirus-mediated gene transfer in the transplant setting: early events after orthotopic transplantation of liver allografts expressing TGF-beta1. Transplantation 62(8): 1080-4, Oct 27 1996.
  84. Farmer, D G.  Shaked, A.  McDiarmid, S V.  Olthoff, K M.  Millis, J M.  Imagawa, D K.  Colonna, J O.  Robert, M E.  Lewin, K.  Goldstein, L I.  Busuttil, R W.: Small intestine transplantation at the University of California, Los Angeles. Transplantation Proceedings 28(5): 2746-7, Oct 1996.
  85. Benhamou, P Y.  Mullen, Y.  Shaked, A.  Bahmiller, D.  Csete, M E.: Decreased alloreactivity to human islets secreting recombinant viral interleukin 10. Transplantation 62(9): 1306-12, Nov 15 1996.
  86. Olthoff, K M.  Rosove, M H.  Shackleton, C R.  Imagawa, D K.  Farmer, D G.  Northcross, P.  Pakrasi, A L.  Martin, P.  Goldstein, L I.  Shaked, A.  Busuttil, R W.: Continuous infusional 5-fluorouracil chemotherapy. Annals of Surgery 224(5): 686, Nov 1996.
  87. Deng, S.  Ketchum, R J.  Kucher, T.  Weber, M.  Shaked, A.  Naji, A.  Brayman, K L.: Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival. Transplantation Proceedings 29(1-2): 770, Feb-Mar 1997.
  88. Holt, C D.  Winston, D J.  Kubak, B.  Imagawa, D K.  Martin, P.  Goldstein, L.  Olthoff, K.  Millis, J M.  Shaked, A.  Shackleton, C R.  Busuttil, R W.: Coccidioidomycosis in liver transplant patients. Clinical Infectious Diseases 24(2): 216-21, Feb 1997.
  89. Millis, J M.  Melinek, J.  Csete, M.  Imagawa, D K.  Olthoff, K M.  Neelankanta, G.  Braunfeld, M Y.  Sopher, M J.  Chan, S M.  Pregler, J L.  Yersiz, H.  Busuttil, A A.  Shackleton, C R.  Shaked, A.  Busuttil, R W.: Randomized controlled trial to evaluate flush and reperfusion techniques in liver transplantation. Transplantation 63(3): 397-403, Feb 15 1997.
  90. Olthoff, K M.  Da Chen, X.  Gelman, A.  Turka, L.  Shaked, A.: Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell anergy. Transplantation Proceedings 29(1-2): 1030-1, Feb-Mar 1997.
  91. Sellers, M.  Singer, A.  Maller, E.  Olthoff, K.  Jacobowski, D.  Shaked, A.: Incidence of late acute rejection and progression to chronic rejection in pediatric liver recipients. Transplantation Proceedings 29(1-2): 428-9, Feb-Mar 1997.
  92. Shaked, A.  Olthoff, K.  Sellers, M.  Chen, X D.  Gelman, A.: Tolerance to a second donor-matched allograft following local immune modulation using transfer of sequences encoding CTLA4Ig. Transplantation Proceedings 29(1-2): 1026, Feb-Mar 1997.
  93. Weber, M.  Deng, S.  Kucher, T.  Shaked, A.  Ketchum, R J.  Brayman, K L.: Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function. Journal of Surgical Research 69(1): 23-32, Apr 1997.
  94. Weber, M.  Deng, S.  Kucher, T.  Shaked, A.  Ketchum, R J.  Brayman, K L.: Increased DNA fragmentation in isolated rat islets following 24 hour co-culture with cytokine transgene-bearing adenovirus is dose dependent, but does not reduce glucose-stimulated insulin secretion. Transplantation Proceedings 29(3): 1728-9, May 1997.
  95. Deng, S.  Ketchum, R J.  Kucher, T.  Weber, M.  Shaked, A.  Naji, A.  Brayman, K L.: IL-10 and TGF-beta gene transfer for xenogeneic islet transplantation: comparison of effect in concordant vs discordant combination. Transplantation Proceedings 29(4): 2204-5, Jun 1997.
  96. Deng, S.  Ketchum, R J.  Yang, Z D.  Kucher, T.  Weber, M.  Shaked, A.  Naji, A.  Brayman, K L.: IL-10 and TGF-beta gene transfer to rodent islets: effect on xenogeneic islet graft survival in naive and B-cell-deficient mice. Transplantation Proceedings 29(4): 2207-8, Jun 1997.
  97. Deng, S.  Yang, Z D.  Ketchum, R J.  Kucher, T.  Weber, M.  Shaked, A.  Naji, A.  Brayman, K L.: Transfer of genes for IL-10 and TGF-beta to isolated human pancreatic islets. Transplantation Proceedings 29(4): 2206, Jun 1997.
  98. Qin, L.  Ding, Y.  Pahud, D R.  Robson, N D.  Shaked, A.  Bromberg, J S.: Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Human Gene Therapy 8(11): 1365-74, Jul 20 1997.
  99. Drazan, K E.  Hebebrand, D.  Shaked, A.  Jones, N F.: Gene transfer into nerve and muscle by isolated limb perfusion or during replantation. Journal of Reconstructive Microsurgery 13(6): 383-7, Aug 1997.
  100. Shaked, A.  Nunes, F A.  Olthoff, K M.  Lucey, M R.: Assessment of liver function: pre- and peritransplant evaluation. [Review] [53 refs] Clinical Chemistry 43(8 Pt 2): 1539-45, Aug 1997.
  101. Shaked, A.: Use of T tube in liver transplantation. [Review] [11 refs] Liver Transplantation & Surgery 3(5 Suppl 1): S22-3, Sep 1997.
  102. Olthoff, K M.  Judge, T A.  Gelman, A E.  da Shen, X.  Hancock, W W.  Turka, L A.  Shaked, A.: Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nature Medicine 4(2): 194-200, Feb 1998.
  103. Weber, M.  Deng, S.  Olthoff, K.  Naji, A.  Barker, C F.  Shaked, A.  Brayman, K L.: Organ transplantation in the twenty-first century. [Review] [126 refs] Urologic Clinics of North America 25(1): 51-61, Feb 1998.
  104. Cherukuri, R.  Haskal, Z J.  Naji, A.  Shaked, A.: Percutaneous thrombolysis and stent placement for the treatment of portal vein thrombosis after liver transplantation: long-term follow-up. Transplantation 65(8): 1124-6, Apr 27 1998.
  105. Liu, C.  Deng, S.  Yang, Z.  Kucher, T.  Guo, F.  Gelman, A.  Chen, H.  Naji, A.  Shaked, A.  Brayman, K L.: Local production of CTLA4-Ig by adenoviral-mediated gene transfer to the pancreas induces permanent allograft survival and donor-specific tolerance. Transplantation Proceedings 31(1-2): 625-6, Feb-Mar 1999.
  106. Rosengard, B R.  Shaked, A.: Persistence of donor antigen is necessary for maintenance of xenotolerance--a parallel to allogeneic systems. [Review] [5 refs] Transplantation 68(8): 1095-6, Oct 27 1999.
  107. Marcucci, L.  Shaked, A.  Maller, E S.  Rand, E B.  Hahn, E S.  Higuchi, N H.  Barker, C F.  Olthoff, K M.: Supraceliac aortic pseudoaneurysms after liver transplantation in infants. Transplantation 68(10): 1617-9, Nov 27 1999.
  108. Zamir, G A.  Olthoff, K M.  Nunes, F A.  Markmann, J F.  Zeldin, G A.  Stewart, C A.  Weinreib, R M.  Rand, E B.  Maller, E S.  Lucey, M R.  Shaked, A.: Liver transplantation at the University of Pennsylvania and the Children''s Hospital of Philadelphia. Clinical Transplants Page: 223-9, 1999.
  109. Porter, D.  Shaked, A.: Exploring the potential for graft vs. tumor response in a combine bone marrow and liver transplantation for large hepatocellular carcinoma. Transplantation 69(10): 2003-4, May 27 2000.
  110. Pfau, P R.  Kochman, M L.  Lewis, J D.  Long, W B.  Lucey, M R.  Olthoff, K.  Shaked, A.  Ginsberg, G G.: Endoscopic management of postoperative biliary complications in orthotopic liver transplantation. Gastrointestinal Endoscopy 52(1): 55-63, Jul 2000.
  111. Zamir, G A.  Markmann, J F.  Abrams, J.  Macatee, M R.  Nunes, F A.  Shaked, A.  Olthoff, K M.: The fate of liver grafts declined for subjective reasons and transplanted out of a local organ procurement organization. Transplantation 70(8): 1149-54, Oct 27 2000.
  112. Liu, C.  Deng, S.  Jiang, K.  Gelman, A.  Shaked, A.  Brayman, K L.: Mechanism of adenoviral-mediated CTLA4-IG gene-induced pancreatic allograft tolerance in rats. Transplantation Proceedings 33(1-2): 134, Feb-Mar 2001.
  113. Liu, C.  Jiang, K.  Deng, S.  Gelman, A.  Shaked, A.  Brayman, K L.: Long-term localized transgene expression in the pancreas achieved by intra-arterial adenoassociated virus-mediated gene transfer. Transplantation Proceedings 33(1-2): 603, Feb-Mar 2001.
  114. Venkataramanan, R.  Shaw, L M.  Sarkozi, L.  Mullins, R.  Pirsch, J.  MacFarlane, G.  Scheller, D.  Ersfeld, D.  Frick, M.  Fitzsimmons, W E.  Virji, M.  Jain, A.  Brayman, K L.  Shaked, A.: Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients. Journal of Clinical Pharmacology 41(5): 542-51, May 2001.
  115. Zamir, G.  Gelman, A E.  Debonera, F.  Hardwigsen, J.  Que, X.  Aldeguer, X.  Martin, M.  Shaked, A.  Olthoff, K M.: Modified AdCTLA-4 vector blocks alloimmune response in vitro. Journal of Surgical Research 97(2): 155-8, May 15 2001.
  116. Shaked, A.  Lucey, M R.: Transplantation of liver grafts from living donors into adults. New England Journal of Medicine 345(12): 923-4, Sep 20 2001.
  117. Singer, A L.  Olthoff, K M.  Kim, H.  Rand, E.  Zamir, G.  Shaked, A.: Role of plasmapheresis in the management of acute hepatic failure in children. Annals of Surgery 234(3): 418-24, Sep 2001.
  118. Markmann, J F.  Shaked, A.: Immunomodulation by intrathymic injection of donor leukocytes in rhesus monkeys. Transplantation 2001; 72: 1432. Transplantation 72(8): 1351-2, Oct 27 2001.
  119. Velidedeoglu, E.  Desai, N M.  Campos, L.  Olthoff, K M.  Shaked, A.  Nunes, F.  Zeldin, G.  Stewart, C.  Blumberg, E.  Abrams, J.  Markmann, J F.: Effect of donor hepatitis C on liver graft survival. Transplantation Proceedings 33(7-8): 3795-6, Nov-Dec 2001.
  120. Olthoff, K M.  Gelman, A E.  Zamir, G A.  Debonera, F.  Krasinkas, A M.  Shen, X.  Gao, F.  Shaked, A.: Pattern of alloimmune response in second same donor allografts after induction of tolerance using CTLA4Ig. Transplantation 72(12): 1952-6, Dec 27 2001.
  121. Aldeguer, Xavier.  Debonera, Fotini.  Shaked, Abraham.  Krasinkas, Alyssa M.  Gelman, Andrew E.  Que, Xingyi.  Zamir, Gideon A.  Hiroyasu, Shungo.  Kovalovich, Kellen K.  Taub, Rebecca.  Olthoff, Kim M.: Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. Hepatology 35(1): 40-8, Jan 2002.
  122. Velidedeoglu, Ergun.  Desai, Niraj M.  Campos, Louis.  Olthoff, Kim M.  Shaked, Abraham.  Nunes, Frederick.  Zeldin, Gillian.  Stewart, Charmaine.  Blumberg, Emily.  Abrams, John.  Markmann, James F.: The outcome of liver grafts procured from hepatitis C-positive donors. Transplantation 73(4): 582-7, Feb 27 2002.
  123. Velidedeoglu, E.  Crawford, M D.  Desai, N M.  Campos, L.  Abt, P L.  Markmann, J W.  Mange, K C.  Bloom, R.  Olthoff, K M.  Shaked, A.  Markmann, J F.: Predictors of late kidney dysfunction post-liver transplantation. Transplantation Proceedings 34(8): 3315-6, Dec 2002.
  124. Zamir, Gideon.  Olthoff, Kim M.  Desai, Niraj.  Markmann, James F.  Shaked, Abraham.: Toward further expansion of the organ pool for adult liver recipients: splitting the cadaveric liver into right and left lobes. Transplantation 74(12): 1757-61, Dec 27 2002.
  125. Abt, Peter.  Crawford, Michael.  Desai, Niraj.  Markmann, James.  Olthoff, Kim.  Shaked, Abraham.: Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation 75(10): 1659-63, May 27 2003.
  126. Htaik, Tun Tin.  Santaniello, Nicole A.  Markmann, James F.  Shaked, Abraham.  Clark, Timothy W I.: Treatment of obstructive nephroureteral clot with a rheolytic mechanical thrombectomy device. Journal of Vascular & Interventional Radiology 14(7): 933-6, Jul 2003.
  127. Shah, Janak N.  Haigh, W Geoffrey.  Lee, Sum P.  Lucey, Michael R.  Brensinger, Colleen M.  Kochman, Michael L.  Long, William B.  Olthoff, Kim.  Shaked, Abraham.  Ginsberg, Gregory G.: Biliary casts after orthotopic liver transplantation: clinical factors, treatment, biochemical analysis. American Journal of Gastroenterology 98(8): 1861-7, Aug 2003.
  128. Abt P, Crawford M, Desai N, Markmann J, Olthoff K, Shaked A: Liver transplantation from controlled non-heart beating donors: An increased incidence of biliary complications. Transplantation 75(10): 1659-1663, 2003.
  129. Debonera, Fotini.  Krasinkas, Alyssa M.  Gelman, Andrew E.  Aldeguer, Xavier.  Que, Xingye.  Shaked, Abraham.  Olthoff, Kim M.: Dexamethasone inhibits early regenerative response of rat liver after cold preservation and transplantation. Hepatology 38(6): 1563-72, Dec 2003.
  130. Shah, JN, Haigh WG, Lee SP, Lucey MR, Brensinger C, Kochman ML, Long WB, Olthoff K, Shaked A, Ginsberg GG: Biliary casts following adult orthotopic liver transplantation: Clinical factors, treatment, and biochemical analysis. Amer J Gastroenterol 98: 1861-1867, 2003.
  131. Krasinskas, Alyssa M.  Minda, Justina.  Saul, Scott H.  Shaked, Abraham.  Furth, Emma E.: Redistribution of thorotrast into a liver allograft several years following transplantation: a case report. Modern Pathology 17(1): 117-20, Jan 2004.
  132. Velidedeoglu, Ergun.  Bloom, Roy D.  Crawford, Michael D.  Desai, Niraj M.  Campos, Luis.  Abt, Peter L.  Markmann, Joseph W.  Mange, Kevin C.  Olthoff, Kim M.  Shaked, Abraham.  Markmann, James F.: Early kidney dysfunction post liver transplantation predicts late chronic kidney disease. Transplantation 77(4): 553-6, Feb 27 2004.
  133. Stewart, Charmaine A.  Wertheim, Jason.  Olthoff, Kim.  Furth, Emma E.  Brensinger, Colleen.  Markman, James.  Shaked, Abraham.: Ascites after liver transplantation--a mystery. Liver Transplantation 10(5): 654-60, May 2004.
  134. Shah, Janak N.  Ahmad, Nuzhat A.  Shetty, Kirti.  Kochman, Michael L.  Long, William B.  Brensinger, Colleen M.  Pfau, Patrick R.  Olthoff, Kim.  Markmann, James.  Shaked, Abraham.  Reddy, K Rajender.  Ginsberg, Gregory G.: Endoscopic management of biliary complications after adult living donor liver transplantation. American Journal of Gastroenterology 99(7): 1291-5, Jul 2004.
  135. Shetty, Kirti.  Timmins, Kate.  Brensinger, Colleen.  Furth, Emma E.  Rattan, Sushil.  Sun, Weijing.  Rosen, Mark.  Soulen, Michael.  Shaked, Abraham.  Reddy, K Rajender.  Olthoff, Kim M.: Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome. Liver Transplantation 10(7): 911-8, Jul 2004.
  136. Abt, Peter L.  Mange, Kevin C.  Olthoff, Kim M.  Markmann, James F.  Reddy, K Rajender.  Shaked, Abraham.: Allograft survival following adult-to-adult living donor liver transplantation. American Journal of Transplantation 4(8): 1302-7, Aug 2004.
  137. Abt, Peter L.  Rapaport-Kelz, Rachel.  Desai, Niraj M.  Frank, Adam.  Sonnad, Seema.  Rand, Elizabeth.  Markmann, James F.  Shaked, Abraham.  Olthoff, Kim M.: Survival among pediatric liver transplant recipients: impact of segmental grafts. Liver Transplantation 10(10): 1287-93, Oct 2004.
  138. Olthoff, Kim M.  Brown, Robert S Jr.  Delmonico, Francis L.  Freeman, Richard B.  McDiarmid, Sue V.  Merion, Robert M.  Millis, J Michael.  Roberts, John P.  Shaked, Abraham.  Wiesner, Russell H.  Lucey, Michael R.: Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA. Liver Transplantation 10(10 Suppl 2): A6-22, Oct 2004.
  139. Zamir, Gideon.  Gelman, Andrew E.  Olthoff, Kim M.  Debonera, Fotini.  Aldeguer, Xavier.  Shaked, Abraham.: Patterns of transgene expression and viral clearance from the transplanted liver following ex vivo adenovirus-mediated gene transfer. Journal of Hepatology 41(5): 714-20, Nov 2004.
  140. Debonera, Fotini.  Wang, Guodong.  Xie, Jinfu.  Que, Xingye.  Gelman, Andrew.  Leclair, Cynthia.  Xin, Dong.  Shaked, Abraham.  Olthoff, Kim M.: Severe preservation injury induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation. American Journal of Transplantation 4(12): 1964-71, Dec 2004.
  141. Halpern, Scott D.  Asch, David A.  Shaked, Abraham.  Stock, Peter G.  Blumberg, Emily.: Determinants of transplant surgeons'' willingness to provide organs to patients infected with HBV, HCV or HIV. American Journal of Transplantation 5(6): 1319-25, Jun 2005.
  142. Campbell, Mical S.  Kotlyar, David S.  Brensinger, Colleen M.  Lewis, James D.  Shetty, Kirti.  Bloom, Roy D.  Markmann, James F.  Olthoff, Kim M.  Shaked, Abraham.  Reddy, K Rajender.: Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation. Liver Transplantation 11(9): 1048-55, Sep 2005.
  143. Abt, Peter L.  Abdullah, Ibrahim.  Korenda, Kathleen.  Frank, Adam.  Peterman, Heather.  Stephenson, G Robert.  Markmann, James F.  Shaked, Abraham.  Olthoff, Kim M.: Appendicitis among liver transplant recipients. Liver Transplantation 11(10): 1282-4, Oct 2005.
  144. Shaked, Abraham.: The interrelation between recurrent hepatitis C, alloimmune response, and immunosuppression. Liver Transplantation 11(11): 1329-31, Nov 2005.
  145. Blonski, Wojciech C.  Reddy, K Rajender.  Shaked, Abraham.  Siegelman, Evan.  Metz, David C.: Liver transplantation for metastatic neuroendocrine tumor: a case report and review of the literature. [Review] [66 refs] World Journal of Gastroenterology 11(48): 7676-83, Dec 28 2005.
  146. Canter, R J.  Abt, P L.  Litzky, L A.  Frank, A.  Abt, A B.  Sellers, M T.  Markmann, J F.  Olthoff, K M.  Naji, A.  Shaked, A.: Successful liver, kidney, and pancreas transplantation from a donor with cerebral emboli from a left atrial myxoma. Transplantation Proceedings 37(10): 4334-6, Dec 2005.
  147. Porrett, Paige M.  Peterman, Heather.  Rosen, Mark.  Sonnad, Seema.  Soulen, Michael.  Markmann, James F.  Shaked, Abraham.  Furth, Emma.  Reddy, K Rajender.  Olthoff, Kim.: Lack of benefit of pre-transplant locoregional hepatic therapy for hepatocellular cancer in the current MELD era. Liver Transplantation 12(4): 665-73, Apr 2006.
  148. Halpern, Scott D.  Asch, David A.  Shaked, Abraham.  Stock, Peter.  Blumberg, Emily A.: Inadequate hepatitis B vaccination and post-exposure evaluation among transplant surgeons: prevalence, correlates, and implications. Annals of Surgery 244(2): 305-9, Aug 2006.
  149. Bortecen, Kerem H.  Moore, Derek.  Fayek, Sameh A.  Shaked, Abraham.: Treatment of hepatic artery-biliary fistula in the setting of liver transplantation. Clinical Transplants Page: 583-5, 2006.
  150. Zamir, Gideon.  Zeira, Evelyne.  Gelman, Andrew E.  Shaked, Abraham.  Olthoff, Kim M.  Eid, Ahmed.  Galun, Eithan.: Replication-deficient adenovirus induces host topoisomerase I activity: implications for adenovirus-mediated gene expression. Molecular Therapy: the Journal of the American Society of Gene Therapy 15(4): 772-81, Apr 2007.
  151. Campbell, Mical S.  Rai, Jitha.  Kozin, Elliott.  Bloom, Roy D.  Markmann, James F.  Olthoff, Kim M.  Shaked, Abraham.  Rajender Reddy, K.: Effects of sirolimus vs. calcineurin inhibitors on renal dysfunction after orthotopic liver transplantation. Clinical Transplantation 21(3): 377-84, May-Jun 2007.
  152. Patel, Himisha.  Vogl, Dan T.  Aqui, Nicole.  Shaked, Abraham.  Olthoff, Kim.  Markmann, James.  Reddy, Rajender.  Stadtmauer, Edward A.  Schuster, Stephen.  Tsai, Donald E.: Posttransplant lymphoproliferative disorder in adult liver transplant recipients: a report of seventeen cases. Leukemia & Lymphoma 48(5): 885-91, May 2007.
  153. Mandell, M Susan.  Stoner, Tamara J.  Barnett, Rebecca.  Shaked, Abraham.  Bellamy, Mark.  Biancofiore, Gianni.  Niemann, Claus.  Walia, Ann.  Vater, Youri.  Tran, Zung V.  Kam, Igal.: A multicenter evaluation of safety of early extubation in liver transplant recipients. Liver Transplantation 13(11): 1557-63, Nov 2007.
  154. Berg, Carl L.  Gillespie, Brenda W.  Merion, Robert M.  Brown, Robert S Jr.  Abecassis, Michael M.  Trotter, James F.  Fisher, Robert A.  Freise, Chris E.  Ghobrial, R Mark.  Shaked, Abraham.  Fair, Jeffrey H.  Everhart, James E.  A2ALL Study Group.: Improvement in survival associated with adult-to-adult living donor liver transplantation. Gastroenterology 133(6): 1806-13, Dec 2007.
  155. Fayek, S.  Moore, D.  Bortecen, K H.  Yeh, H.  Markmann, J F.  Olthoff, K M.  Shaked, A.: Liver transplantation in the setting of extra-hepatic malignancy: two case reports. Transplantation Proceedings 39(10): 3512-4, Dec 2007.
  156. Bahirwani, Ranjeeta.  Campbell, Mical S.  Siropaides, Tim.  Markmann, James.  Olthoff, Kim.  Shaked, Abraham.  Bloom, Roy D.  Reddy, K Rajender.: Transplantation: impact of pretransplant renal insufficiency. Liver Transplantation 14(5): 665-71, May 2008.
  157. Halpern, Scott D.  Shaked, Abraham.  Hasz, Richard D.  Caplan, Arthur L.: Informing candidates for solid-organ transplantation about donor risk factors. New England Journal of Medicine 358(26): 2832-7, Jun 26 2008.
  158. Nakamoto, Nobuhiro.  Kaplan, David E.  Coleclough, Jennifer.  Li, Yun.  Valiga, Mary E.  Kaminski, Mary.  Shaked, Abraham.  Olthoff, Kim.  Gostick, Emma.  Price, David A.  Freeman, Gordon J.  Wherry, E John.  Chang, Kyong-Mi.: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7): 1927-37, 1937.e1-2, Jun 2008.
  159. Hoffman, S A.  Wang, L.  Shah, C V.  Ahya, V N.  Pochettino, A.  Olthoff, K.  Shaked, A.  Wille, K.  Lama, V N.  Milstone, A.  Ware, L B.  Orens, J.  Weinacker, A.  Demissie, E.  Bellamy, S.  Kawut, S M.  Hancock, W W.  Christie, J D.  Lung Transplant Outcomes Group.: Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. American Journal of Transplantation 9(2): 389-96, Feb 2009.
  160. Nakamoto, Nobuhiro.  Cho, Hyosun.  Shaked, Abraham.  Olthoff, Kim.  Valiga, Mary E.  Kaminski, Mary.  Gostick, Emma.  Price, David A.  Freeman, Gordon J.  Wherry, E John.  Chang, Kyong-Mi.: Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathogens 5(2): e1000313, Feb 2009.
  161. Northup Patrick G, Abecassis Michael M, Englesbe Michael J, Emond Jean C, Lee Vanessa D, Stukenborg George J, Tong Lan, Berg Carl L,  : Addition of adult-to-adult living donation to liver transplant programs improves survival but at an increased cost. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 15(2): 148-62, Feb 2009.
  162. Shaked, A.  Ghobrial, R M.  Merion, R M.  Shearon, T H.  Emond, J C.  Fair, J H.  Fisher, R A.  Kulik, L M.  Pruett, T L.  Terrault, N A.  A2ALL Study Group.: Incidence and severity of acute cellular rejection in recipients undergoing adult living donor or deceased donor liver transplantation. American Journal of Transplantation 9(2): 301-8, Feb 2009.
  163. de Jonge, J.  Kurian, S.  Shaked, A.  Reddy, K R.  Hancock, W.  Salomon, D R.  Olthoff, K M.: Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. American Journal of Transplantation 9(4): 758-72, Apr 2009.
  164. Marin, Horia L.  Furth, E Elizabeth.  Olthoff, Kim.  Shaked, Abraham.  Soulen, Michael C.: Histopathologic outcome of neoadjuvant image-guided therapy of hepatocellular carcinoma. Journal of Gastrointestinal & Liver Diseases 18(2): 169-76, Jun 2009.
  165. Porrett Paige M, Hsu John, Shaked Abraham: Late surgical complications following liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 15 Suppl 2: S12-8, Nov 2009.
  166. Merion Robert M, Shearon Tempie H, Berg Carl L, Everhart James E, Abecassis Michael M, Shaked Abraham, Fisher Robert A, Trotter James F, Brown Robert S, Terrault Norah A, Hayashi Paul H, Hong Johnny C,  : Hospitalization rates before and after adult-to-adult living donor or deceased donor liver transplantation. Annals of surgery 251(3): 542-9, Mar 2010.
  167. Gillespie B W, Merion R M, Ortiz-Rios E, Tong L, Shaked A, Brown R S, Ojo A O, Hayashi P H, Berg C L, Abecassis M M, Ashworth A S, Friese C E, Hong J C, Trotter J F, Everhart J E,  : Database comparison of the adult-to-adult living donor liver transplantation cohort study (A2ALL) and the SRTR U.S. Transplant Registry. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 10(7): 1621-33, Jul 2010.
  168. Olthoff Kim M, Kulik Laura, Samstein Benjamin, Kaminski Mary, Abecassis Michael, Emond Jean, Shaked Abraham, Christie Jason D: Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 16(8): 943-9, Aug 2010.
  169. Cassuto J R, Reese P P, Sonnad S, Bloom R D, Levine M H, Olthoff K M, Shaked A, Naji A, Abt P: Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 10(11): 2502-11, Nov 2010.
  170. Trotter JF, Gillespie BW, Terrault NA, Abecassis MM, Merion RM, Brown RS Jr, Olthoff KM, Hayashi PH, Berg CL, Fisher RA, Everhart JE: Laboratory test results after living liver donation in the adult-to-adult living donor liver transplantation cohort study. Liver Transpl 17(4): 409-417, April 2011.
  171. Olthoff KM, Abecassis MM, Emond JC, Kam I, Merion RM, Gillespie BW, Tong L, Shaked A: Outcomes of adult living donor liver transplantation; comparison of the adult-to-adult living donor liver transplantation cohort study and the national experience. Liver Transplantation 17(7): 789-797, July 2011.
  172. Sun W, Sohal D, Haller DG, Mykulowzcz K, Rosen M, Soulen MC, Caparro M, Teitelbaum UR, Giantonio B, O'Dwyer PJ, Shaked A, Reddy R, Olthoff K: Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma. Cancer 15(14): 3187-3192, July 2011.
  173. Bunchomtavakul C, Bahiwani R, Drazek D, Soulen MC, Siegelman ES, Furth EE, Olthoff K, Shaked A, Reddy KR.  : Clinical features and natural history of hepatocellular adenomas:  the impact of obesity. Aliment Pharmacol Ther 34(6): 664-674, September 2011.
  174. Eshel K, Sansone E, Shaked A: On the evolution of group-escape strategies of selfish prey. Theoretical Population Biology 80(2), September 2011.
  175. Schlitt Hans J, Mornex Françoise, Shaked Abraham, Trotter James F: Immunosuppression and hepatocellular carcinoma. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 17 Suppl 2: S159-61, Oct 2011.
  176. Foroohar A, Elliott RM, Fei L, Steinberg DR, Bozentka DJ, Chang B, Kovach SJ, Shaked A, Levin LS: Quadrimembral amputation: indication and contraindications for vascularized composite allotransplantation. Transplantation Proceedings 43(9): 3521-3528, November 2011.
  177. Foroohar Abtin, Elliott River M, Kim Tae Won Benjamin, Breidenbach Warren, Shaked Abraham, Levin L Scott: The history and evolution of hand transplantation. Hand clinics 27(4): 405-9, vii, Nov 2011.
  178. Clavien PA, Lesurtel M, Bossuyl PM, Gores GJ, Langer B, Perrier A, Shaked A: Recommendations for liver transplantation for hepatocellular carcinoma; an international consensus conference group; OLT for HCC Consensus Group. Lancet Oncology 13(1): 11-22, January 2012.
  179. Friedman Benjamin H, Wolf Joshua H, Wang Liqing, Putt Mary E, Shaked Abraham, Christie Jason D, Hancock Wayne W, Olthoff Kim M: Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 18(2): 166-76, Feb 2012.
  180. Reese Peter P, Bloom Roy D, Feldman Harold I, Huverserian Ari, Thomasson Arwin, Shults Justine, Hamano Takayuki, Goral Simin, Shaked Abraham, Olthoff Kimberly, Rickels Michael R, Bleicher Melissa, Leonard Mary B: Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation. Liver international : official journal of the International Association for the Study of the Liver 32(2): 287-96, Feb 2012.
  181. Levitsky Josh, Fiel Maria Isabel, Norvell John P, Wang Edward, Watt Kymberly D, Curry Michael P, Tewani Sumeet, McCashland Timothy M, Hoteit Maarouf A, Shaked Abraham, Saab Samuel, Chi Amanda C, Tien Amy, Schiano Thomas D: Risk for immune-mediated graft dysfunction in liver transplant recipients with recurrent HCV infection treated with pegylated interferon. Gastroenterology 142(5): 1132-1139, May 2012.
  182. Sonnenberg Gregory F, Monticelli Laurel A, Alenghat Theresa, Fung Thomas C, Hutnick Natalie A, Kunisawa Jun, Shibata Naoko, Grunberg Stephanie, Sinha Rohini, Zahm Adam M, Tardif Mélanie R, Sathaliyawala Taheri, Kubota Masaru, Farber Donna L, Collman Ronald G, Shaked Abraham, Fouser Lynette A, Weiner David B, Tessier Philippe A, Friedman Joshua R, Kiyono Hiroshi, Bushman Frederic D, Chang Kyong-Mi, Artis David: Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (New York, N.Y.) 336(6086): 1321-5, Jun 2012.
  183. Porrett Paige M, Horst Matthijs Ter, Shaked Abraham: Donor assessement scores: Relevance and complete irrelevance. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Jul 2012.
  184. Cui Rosa, Fayek Sameh, Rand Elizabeth B, Feygin Tamara, Khrichenko Dmitry, Shaked Abraham: Central pontine myelinolysis: A case report and clinical-pathological review. Pediatric transplantation 16(6): 251-256, September 2012.
  185. Banff Working Group on liver allograft pathology; Shaked A: Importance of liver biopsy findings in immunosuppression management biopsy monitoring and working criteria for patients with operational tolerance. Liver Transplantation 18(10): 1154-1170, October 2012.
  186. Kulik LM, Fisher RA, Rodrigo DR, Brown RS Jr., Freise CE, Shaked A, Everhart JE, Everson GT, Hong JC, Hayashi PH, Berg CL, Lok AS: Outcomes of living and deceased donor liver transplant recipients with hepatocellular carcinoma: results of the A2ALL cohort.   American Journal of Transplantation 12(11): 2997-3007, November 2012.
  187. Porrett PM, Horst M, Shaked A: Donor assessment scores: relevance and complete irrelevance. Liver Transplantation(Suppl 2), S25-30, November 2012.
  188. Aufhauser DD Jr, Rose T, levine M, Barnett R, Ochroch EA, Aukburg S, Greenblatt E, Olthoff K, Shaked A, Abt P: Cardiac arrest associated with reperfusion of the liver during transplantation; incidence and proposal for a management algorithm. Clinical Transplantation December 2012.
Research Publications, peer-reviewed reviews
  1. Mendizabal Manuel, Reddy K Rajender, Cassuto James, Olthoff Kim M, Faust Thomas W, Makar George A, Rand Elizabeth B, Shaked Abraham, Abt Peter L: Liver transplantation in patients with cystic fibrosis: analysis of United Network for Organ Sharing data. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 17(3): 243-50, Mar 2011.
  2. Porrett Paige, Shaked Abraham: The failure of immunosuppression withdrawal: patient benefit is neither detectable, inducible, nor reproducible. Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 17(3): S66-8, November 2011.
 
Awards, Honors and Membership in Honorary Societies:
2011 PENN's Louis Duhring Outstanding Clinical Specialist award
 
2006 - 2007 American Society of Transplant Surgeons/ Roche Laboratories Presidential Travel Award
 
1996 American Liver Foundation Physician of the Year Award
 
1992 American Society of Transplant Surgeons Faculty Career Development Award
 
1989 "Arthur A. Aufses Award" for Outstanding Chief Resident
Mount Sinai Medical Center, New York, New York
 
1986 Third Annual Research Day Student Award, Department of Medicine
Mount Sinai Medical Center, New York, New York
 
1986 American Federation of Clinical Research Student Award
 
1984 "Adam Pedegrin Award" for Outstanding M.D. Thesis, Jerusalem, Israel
 
1975 - 1977 Scholarship Awards for Outstanding Medical Student

Dr. Abraham Shaked

 
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