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Sunil Singhal, M.D.
Thoracic Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
6 White Building
Philadelphia, PA 19104
Administrative Assistant: Timothy Nichols
Administrative Telephone: 215-662-4767
Administrative Fax: 215-615-6562

Clinical Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
4 Silverstein Pavilion
Philadelphia, PA 19104
Clinical Telephone: 215-662-4767
Clinical Fax:
215-615-6562

Contact Information (internal use only)

sunil.singhal@uphs.upenn.edu

 

Dr. Sunil Singhal is a General Thoracic Surgeon and practices surgery on all aspects of the chest.  His practice is focused on lung cancer and esophageal cancer, including complex resections and advanced disease.  He performs minimally invasive (VATS and robotic) pulmonary surgery.  In addition, he performs mediastinal surgery (diseases of the thymus gland), pleural disease, microinvasive hyperhidrosis surgery and pectus excavatum (Ravitch and Nuss repairs).

Dr. Singhal is the Director of the Thoracic Surgery Research Laboratory and his interest lie in intraoperative imaging to detect small quantities of disease and immunotherapy to treat patients with advanced lung and thymic cancer.  He is conducting several clinical trials to improve care for patients with advanced disease for cure.

Special Interests:
  • Lung cancer
  • Minimally invasive VATS surgery
  • Robotic surgery
  • Barrett’s esophagus
  • Thymoma
  • Myasthenia Gravis
  • Pectus Excavatum
 
Faculty Appointments
2007 – 2008 Assistant Professor of Surgery
Emory University School of Medicine
Atlanta, Georgia
 
2008 - present Assistant Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2009 - present University of Pennsylvania School of Medicine
Assistant Professor of Medicine
(secondary appointment)
Department of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2007 - 2008 Staff Physician, Division of Cardiothoracic Surgery
The Emory Clinic, Atlanta, Georgia
 
2007 - 2008 Staff Physician, Section of Cardiothoracic Surgery Veterans Affairs Medical Center
Atlanta, Georgia
 
2007 - 2008 Director of Thoracic Surgery Oncology Research Emory University School of Medicine
Atlanta, Georgia
 
2008 - present Staff Physician, Division of Thoracic Surgery, Veterans Affairs Medical Center
Philadelphia, Pennsylvania
 
2008 - present Chief, Division of Thoracic Surgery, Veterans Affairs Medical Center
Philadelphia, Pennsylvania
 
2008 - present Director, Thoracic Surgery Research Laboratory
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2008 - present Attending Physician
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2008 – present Associate Member (Immunology Research Program)
Abramson Cancer Center
 
2009 – present Peer Reviewer, Philadelphia VA Medical Center
 
2012 Search Committee, Director of Minimally Invasive Surgery
University of Pennsylvania School of Veterinary Medicine
 
Education/Training
1990 - 1994 BA - Dartmouth College (Physics & Mathematics)
 
1994 - 1998 MD - University of Pennsylvania School of Medicine
 
Postgraduate Training and Fellowship Appointments
1998 - 1999 Intern in General Surgery
The Johns Hopkins Hospital
Baltimore, Maryland
 
1999 - 2001 Resident in General Surgery
The Johns Hopkins Hospital
Baltimore, Maryland
 
2001 - 2003 Research Fellow, Cancer Molecular Training Program
Harrison Department of Surgical Research
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2004 - 2005 Resident in General Surgery
The Johns Hopkins Hospital
Baltimore, Maryland
 
2005 - 2007 Fellow in Cardiothoracic Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Memberships/Societies
National/International Societies
  • American Association for the Advancement of Science
  • American Association for Cancer Research
  • American College of Chest Physicians
  • American College of Surgeons
  • American Society of Clinical Oncology
  • American Thoracic Society
  • Association for Academic Surgery
  • General Thoracic Surgery Biology Club
  • International Society for Minimally Invasive Cardiothoracic Surgery
  • Society for Surgery of the Alimentary Tract (candidate member)
  • Society of Surgical Oncology
  • Society of Thoracic Surgeons (candidate member)
Local/Regional Societies
  • The Johns Hopkins Medical and Surgical Association
  • Pennsylvania Society of Thoracic Surgery
Scientific Committees
  • Society of Thoracic Surgery Workforce for Evidence-Based Surgery (2007-present)
 
Research
 
Thoracic Research Laboratory
 
 
 
 
 
 
 
 
Publications
Peer-Reviewed Publications
  1. Singhal S, Wiewrodt R, Friscia M, Matzie K, Friedberg J, Amin KA, Kucharczuk JC, Albelda SM, Kaiser LR. “Genomic profiling to explain positive PET-18FDG imaging in patients with malignant pleural mesothelioma”.  Journal of Surgical Research 107:284, 2002.
  2. Singhal S, Amin K, Kruklitis R, DeLong P, Friscia ME, Putt ME, Kaiser LR, Albelda SM. “Alterations in Cell Cycle Genes in Early Stage Lung Adenocarcinoma Identified by Expression Profiling.” Cancer Biology and Therapy. 2(3), 2003.
  3. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf G, Albelda SM. “Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice.” American Journal of Respiratory and Cellular Molecular Biology. 28(6):682-696, 2003.
  4. Singhal S, Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda SM. “Microarray Data Simulator to Evaluate Bioinformatic Tools for Selecting Differentially Expressed Genes in Normal versus Cancerous Tissues.” Cancer Biology and Therapy. 2(4): 383-394, 2003.
  5. Paulson EC, Singhal S, Kucharczuk JC, Sterman D, Kaiser LR, Marshall MB. “Bronchial sleeve resection for posttransplant stricture.” Annals of Thoracic Surgery. 76(6):2075-6, 2003.
  6. Singhal S, Weiwrodt R, Malden, L, Matzie K, Friedberg J, Amin KM, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. “Gene Expression Profiling of Malignant Mesothelioma.” Clinical Cancer Research. 9: 3080-3097, 2003.
  7. Singhal S, Amin K, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Albelda SM, Kaiser LR. “Differentially Expressed Apoptotic Genes in Node Negative Lung Adenocarcinoma Predicted by Expression Profiling.” Cancer Biology and Therapy. 2:566-571, 2003.
  8. Cook J, Sterman DH, Singhal S, Smythe WR, Kaiser LR. “Suramin Inhibits The Growth Of Malignant Mesothelioma In Vitro, And In Vivo, In Murine Flank And Intraperitoneal Models.” Lung Cancer. 42(3):263-74, 2003.
  9. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. “Comparison of Stages I-II Thymoma Treated by Complete Resection with or without Adjuvant Irradiation.” Annals of Thoracic Surgery. 76:1635-42, 2003.
  10. Kruklitis R, Singhal S, DeLong P, Kapoor V, Sterman D, Kaiser LR, Albelda SM. “Neoadjuvant Immuno-Gene Therapy with Interferon-Beta Before Surgical Debulking Prevents Recurrence and Improves Survival in Advanced Malignant Mesothelioma.”  The Journal of Thoracic and Cardiovascular Surgery. 127(1): 123-130, 2004.
  11. Lee LS, Singhal S, Brinster CJ, Kaiser LR, Marshall MB, Kochman ML, Kucharczuk JC. “Current Management of Esophageal Leiomyoma.” Journal of American College of Surgeons. 198(1):136-46, 2004.
  12. O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. “Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity.” Oncogene. 24:1244-51, 2005.
  13. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. “Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer.” Clinical Cancer Research. 11: 3974-3986, 2005.
  14. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. “Gene Induction During Differentiation of Human Pulmonary Type II Cells In Vitro.” American Journal of Respiratory Cell & Molecular Biology. 34: 727-737, 2006.
  15. Nathan H, Singhal S, Cameron JL. “Benign pneumatosis intestinalis in the setting of celiac disease.” Journal of Gastrointestinal Surgery. 10(6):890-4, 2006.
  16. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. “A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma.” Clinical Cancer Research. 13(10):2905-15, 2007.
  17. Singhal S, Miller DL, Ramalingam S, Sun SY. “Gene Expression Profiling of Non-Small Cell Lung Cancer.” Lung Cancer. 60: 313-324, 2008.
  18. Fabre D, Fadel E, Singhal S, Monpreville VD, Mussot D, Mercier O,  Chataigner O, Dartevelle PG. “Complete Resection of Pulmonary Inflammatory Pseudotumors Has Excellent Long Term Prognosis.” The Journal of Thoracic and Cardiovascular Surgery. Feb; 137(2):435-40, 2009.
  19. Fabre, D, Singhal S, De Montpreville V, Decante B, Mussot S, Chataigner O, Mercier O, Kolb F, Dartevelle PG and Fadel E.  “Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection.” The Journal of Thoracic and Cardiovascular Surgery 138(1): 32-9, 2009.
  20. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LS, Singhal S, Snyder LA, Albelda SM. “CCL2 Blockade Augments Cancer Immunotherapy.” Cancer Research.  Jan; 70(1):109-118, 2010.
  21. Singhal S. Ferraris VA, Bridges CR, Clough ER, Mitchell JD, Fernando HC, Shrager JB. “Postoperative Management of Pulmonary Alveolar Air Leaks.” Annals of Thoracic Surgery. 89(4): 1327-35, 2010.
  22. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S.  “A Handheld Spectroscopic Device for In Vivo and Intraoperative Tumor Detection: Contrast Enhancement, Detection Sensitivity, and Tissue Penetration.” Analytical Chemistry, Oct 6 2010.
  23. Fridlender ZG, Sun J, Singhal S, Kapoor V, Cheng G, Albelda SM. “Chemotherapy delivered after  viral immunogene therapy augments anti-tumor efficacy via multiple immune-mediated mechanisms.” Molecular Therapy, 18(11): 1947-59, 2010.
  24. Singhal S, Shrager JB. “Intraoperative prophylaxis and management of pulmonary parenchymal air leaks.” Journal of Thoracic and Cardiovascular Surgery. 140(6): 1220-5, 2010.
  25. Singhal S, Nie S, Wang MD. “Nanotechnology applications in surgical oncology.” Annu Rev Med; 61:359-373, 2010.
  26. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, Cohen NA, Mirza N. “Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis.” Otolaryngol Head Neck Surg. 144(6):927-33, 2011.
  27. Brunelli, A. Beretta E, Cassivi S., Cerfolio R., Detterbeck F., Kiefer T.,  Miserocchi G., Shrager J, Singhal S, Raemdonck DV, Varela G. “Consensus definitions to promote an evidence-based approach to management of the pleural space.  A collaborative proposal by the ESTS, AATS, STS, and GTSC.” European Journal of Cardiothoracic Surgery. 40: 291-297, 2011.
  28. Levine S, Budak MT, Dierov J, Singhal S. “Inactivity-induced diaphragm dysfunction and mitochondrial-targeted antioxidants.” Critical Care Medicine. 39(7):1844-5, 2011.
  29. Berman AT, Litzky L, Livolsi V, Singhal S, Kucharczuk JC, Cooper JD, Friedberg JR, Evans TL,  Stevenson J, Metz JM, Hahn SM, Rengan R. “Adjuvant Radiotherapy for Completely Resected Stage II Thymoma.” Cancer. 117(15): 3502-8, Feb 1 2011.
  30. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT.   “Increased proteolysis and atrophic AKT-FOXO Signaling in Human Diaphragm Disuse.”American Journal of Respiratory and Critical Care Medicine. 183(4): 483-90, 2011.
  31. Liu G, Su L, Hao X, Zhong N, Singhal S, Liu X. “Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Programmed Cell Death.” Journal of Cellular and Molecular Medicine. July 31 2011.
  32. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LC, Singhal S, Snyder LA and Albelda SM. “Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells." Am J Respir Cell Mol Biol 44(2): 230-7, 2011.
  33. Aliperti LA, Predina JD, Vachani A, Singhal S. “Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery.” Annals of Surgical Oncology. 18(3): 603-607, 2011.
  34. Su L, Liu G, Hao X, Liu X, Zhong N, Zhong D, Singhal S. “Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells.” European Journal of Cancer. 47(16): 2471-8, 2011.
  35. Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V, Nakagawa H, Rustgi AK, Aguilar L, Aguilar-Cordova E, Albelda SM, Singhal S. “Neoadjuvant in situ Gene-Mediated Cytotoxic Immunotherapy Improves Postoperative Outcomes in Novel Syngeneic Esophageal Carcinoma Models.” Cancer Gene Therapy. 18(12): 871-883. 2011.
  36. Tucker ZCG, Laguna BA, Moon E, Singhal S. “Adjuvant immunotherapy for non-small cell lung cancer.” Cancer Treatment Reviews. 38(6):650-61, 2012.
  37. Fridlender ZG,  Sun  J, Mishalian I, Singhal S, Cheng G,  Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM.   “Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils.”  PLoS ONE. 7(2):e31524. 2012.
  38. Predina JD, Judy B, Kapoor V, Blouin A, Aliperti LA, Levine D, Fridlender ZG, Singhal S. “Characterization of Surgical Models of Postoperative Tumor Recurrence For Preclinical Adjuvant Therapy Assessment.” Am J Translational Research. 4(2): 206-218, 2012.
  39. Jia G, Su L, Singhal S, Liu X. “Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging.” Molecular and Cellular Biochemistry. 364(1-2): 345-350, 2012.
  40. Predina JD, Fridlender ZG, Judy B, Kapoor V, Aliperti L, Blouin A, Albelda SM, Singhal S. “The Importance of Well-Characterized Murine Surgical Models of Tumor Recurrence for Preclinical Studies of Adjuvant Therapy.” Cancer Biology and Therapy. 13(9):1-11, 2012.
  41. O'Shannessy D J, Yu G, Smale R, Fu YS, Singhal S, Thiel RP, Somers EB, and Vachani A. “Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance.” Oncotarget. 3(4):414-25, 2012.
  42. Predina JD, Kapoor V, Judy BF, Cheng G, Fridlender ZG, Albelda SM, Singhal S. “Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness.” Journal of Hematology and Oncology. 5(1): 34, 2012.
  43. Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, Singhal S. “Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery.” Neoplasia. 14(4): 352-9, 2012.
  44. Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk J, Singhal S, Vachani A. “MicroRNA expression profiles of whole blood in lung adenocarcinoma.” PLOS One. 7(9): e46045, Sept 2012.
  45. Majumdar D, Singhal S. “Medicinal Chemistry and Nanomedicine for Reproductive Cancer Therapeutics.” Front Biosci (Elite Ed). 4: 2029-44, 2012.
  46. Madajewski B, Judy B, Mouchli A, Kapoor V, Holt D, Wang MD, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease.” Clinical Cancer Research. 18(20): 5741-51. Oct 15, 2012.
  47. Laguna BA, Tucker ZCG, DeLisser H, Singhal S. "Letting the Air in Can Set the Stage for Tumor Recurrences.” Current Cancer Therapy Reviews. 8(4):293-303, Nov 2012.
  48. Fabre D, El Batti S, Singhal S, Mercier O, Mussot O, Fadel E, Kolb F, Dartevelle PG. “A paradigm shift for sternal reconstruction using a novel titanium rib bridge system following oncological resections.” European Journal of Cardiothoracic Surgery. 42(6):965-70. Dec 2012.
  49. Fridlender Z, Jasaar A, Mishalian I, Wang LC, Kapoor V, Cheng G, Sun J, Singhal S, Levy L, and Albelda SM. “Using Macrophage Activation to Augment Immunotherapy of Established Tumors.” British Journal of Cancer. 108(6):1288-97, April 2, 2013.
  50. Levine S, Bashir M, Clanton T, Powers S, Singhal S.  “COPD Elicits Remodeling of the Diaphragm and Vastus Lateralis Muscles in Humans.”  Journal of Applied Physiology. 114(9): 1235-1245.  May 1, 2013.
  51. Ghosh A, Philiponis G, Lee JY, Leahy KP, Singhal S, Cohen NA, Mirza N. "Pulse steroid therapy inhibits murine subglottic granulation." Otolaryngol Head Neck Surg. 148(2): 284-90. Feb 2013.
  52. Li T, Su L, Zhong N, Singhal S, Liu X “Salinomycin Induces Cell Death with autophagy through activation of Endoplasmic Reticulum Stress in Human Lung Cancer cells.” Autophagy. 9(7). April 18, 2013.
  53. Predina JD, Eruslanov E, Judy B, Kapoor V, Cheng GJ, Wang S, Sun J, Fridlender G, Albelda SM, Singhal S. “Changes in the Local Tumor Microenvironment in Recurrent Cancers May Explain the Failure of Vaccines after Surgery.” Proceedings of the National Academy of Sciences USA. 110(5): E415-24. Jan 29, 2013.
  54. Quatromoni JG, Suzuki E, Okusanya O, Judy BF, Bhojnagarwala P, Venegas O, Eruslanov E, Predina JD, Albelda SM, Singhal S. “The timing of TGF-β inhibition affects the generation of antigen-specific CD8+ T Cells.” BMC Immunology. 14:30, 2013.
  55. Waldron TJ, Quatromoni JG, Karakasheva TA, Singhal S, and Rustgi, AK. “Myeloid derived suppressor cells: Targets for therapy.” Oncoimmunology, 2: e2411-7, 2013.
  56. Liu Y, Wang L, Predina J, Han R, Beier UH, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. “Inhibition of p300 Impairs Foxp3+ T-regulatory Cell Function and Promotes Anti-Tumor Immunity.” Nature Medicine. 19(9):1173-7. Sept 2013.
Published Books
  1. Surgical Foundations: Essentials of Thoracic Surgery. Authors: Larry R. Kaiser and Sunil Singhal.  Philadelphia: Elsevier Science. 2004.
Reviews and Book Chapters
  1. Singhal S, Kaiser LR. “Cancer Chemotherapy Using Suicide Genes.” Surgical Oncology Clinics of North America. 7(3):505-536, 1998.
  2. Singhal S, Machtay M, Kaiser LR. “Malignant Mesothelioma.” In: Integrated Cancer Management. ed. Michael Torosian. New York: Marcel Dekker, 1999.
  3. Singhal S, Kaiser LR.  “Benign and Malignant Mesothelioma.” In: Surgical Oncology: Contemporary Principles and Practice. ed. Kirby I. Bland, John M. Daly, and Constantine Karakousis.  New York: McGraw-Hill, 2001.
  4. Singhal S, Johnson C, Udelsman R. “Primary Hyperparathyroidism: What Every Orthopedic Surgeon Should Know.” Orthopedics. 24(10): 1003-1008, 2001.
  5. Singhal S, Kaiser LR. “Malignant Mesothelioma: Options for Management.” Surgical Clinics of North America. 82(4):797-831, 2002.
  6. Singhal S, Shrager JB, Kaiser LR. “Biological Treatments for Lung Cancer.” In: Clinique des Soins Intensifs Oncologiques et de Cancerologie Pulmonaire. Ed. Jean-Paul Sculier and Williard A. Fry. Bruxelles, France: Reseau iris.
  7. Greenberg J, Singhal S, Kaiser LR. “Giant Bullous Disease:  Evaluation, Selection, Techniques, and Outcomes.” Chest Surgery Clinics of North America. 13(4): 631-650. 2003.
  8. Singhal S, Yang S. “Lung Volume Reduction Surgery: Median Sternotomy Approach.” In: Current Therapy in Thoracic and Cardiovascular Surgery. Ed. Stephen Yang and Duke Cameron. 2004.
  9. Brinster CJ, Singhal S, Lee LS, Marshall MB, Kaiser LR, Kucharczuk JC. “Evolving Options in the Management of Esophageal Perforation.”  Annals of Thoracic Surgery. 77: 1475-83, 2004.
  10. Singhal S, Yang S. “Techniques and Results in Lung Transplantation.” In: Advanced Therapy in Thoracic Surgery, 2nd edition. ed. KL Franco and JB Putnam. BC Decker, 2005.
  11. Dunham B, Le Visage CL, Singhal S, Flint P, Leong K. “Tracheal tissue engineering.”  In: Biomedical Engineering Fundamentals (The Biomedical Engineering Handbook), 3rd edition. ed. Bronzino. Boca Raton, FL: CRC Press, 2006.
  12. Singhal S, Kaiser LR. “Video-assisted thoracic surgery.” In: Current Surgical Therapy. 9th edition. Ed. JL Cameron. Elsevier Science, 2007.
  13. Singhal S, Kaiser LR. “Surgery for Myasthenia Gravis.” In: Pearson’s Thoracic Surgery, 3rd edition. Ed. A Patterson. Elsevier Science, 2008.
  14. Singhal S, Shrager J, Kaiser LR. “Neoadjuvant Therapy for Non-Small Cell Lung Cancer.” In: General Thoracic Surgery, 7th edition. ed. Thomas W. Shields, Joseph LoCicero III, Carolyn E. Reed, Richard H. Feins. Chicago: Williams and Wilkins, 2009.
  15. Merritt RE, Singhal S, Shrager JB. “Evidence-based Suggestions for Management of Air Leaks.” Chest Surgical Clinics of North America. 20(3):435-448, 2010.
  16. Moon E, Singhal S, Haas A, Sterman DH, Albelda SM. “Gene Therapy for Malignant Mesothelioma.”  In: Roth J, ed. Gene-Based Therapies for Cancer. 1st ed. New York, NY: Springer; 2010:95-112.
  17. Predina J, Kunkala M, Aliperti L, Singhal S. “Sleeve Lobectomy.”  Annals of Thoracic and Cardiovascular Surgery.  16(5): 310-8, 2010.
  18. Singhal S. “Thoracic Surgery.” In: General Surgery Review. ed. Marty A. Makary. 3rd edition. Lippincott Williams & Wilkins. Philadelphia, 2013.
Audio, Video, CD, Internet and Alternative Media
  1. Baumgartner F, Singhal S. “Sympathectomy for Primary Hyperhidrosis.”  UpToDate.  Online Clinical Reference Library. Version 17.3. 2010. http://www.uptodateonline.com/.
  2. Singhal S. “Esophageal Injury.” Online General Surgery Curriculum. Surgical Council on Resident Education. Sponsored through American Board of Surgery. 2013. http://www.surgicalcore.org.
Abstracts, Letters, Case Reports and Editorials
  1. Singhal S, Ratner L. “Unilateral Renal Agenesis with Pelvic Renal Ectopy.” Journal of the American College of Surgeons. 193(3): 330, 2001.
  2. Singhal S, Johnson C, Udelsman R. “Primary Hyperparathyroidism: What Every Orthopedic Surgeon Should Know.” Orthopedics. Invited CME Quiz, 24(10): 1009-1011, 2001.
  3. Singhal S, Wiewrodt R, Matzie K, Kucharczuk J, Friedberg J, Albelda SM, Kaiser LR. "Gene Expression Mapping to Diagnose Malignant Mesothelioma." Journal of American College of Surgeons. (Surgical Forum) 195(3S): 26-27, 2002.
  4. Singhal S, Kruklitis R, Marshall B, Kucharczuk J, Albelda SM, Kaiser LR. "Viral Gene Transfer of Interleukin-12 prolongs survival and prevents recurrence in early and advanced non-small cell lung cancer." Journal of American College of Surgeons. (Surgical Forum) 197(3S): 28-29, 2003.
  5. Singhal S, Vachani A, Kupferman M, Powell C, Gaffney P, Muschel R, Albelda SM, Kaiser LR. "Gene Expression Profiling to Distinguish Head and Neck Squamous Cell Carcinoma Metastases from Primary Lung Squamous Cell Carcinoma." Journal of American College of Surgeons. (Surgical Forum) 199(3S): 66, 2004.
  6. Singhal S, Cooper JM, Cheung AT, Acker MA. “Rib perforation from a right ventricular pacemaker lead.”  Circulation. 115:391-392, 2007.
  7. Reilly P, Singhal S. “Esophageal Injury: Trauma.”  American College of Surgeons. Review for General Surgery Residents for American Board of Surgery test preparation. March 2009.
  8. Kim SS, Fridlender ZG, Jassar AS, Blouin A, Kapoor V, Albelda SM, Singhal S. “The role of neoadjuvant transforming growth factor beta inhibition to prevent local recurrences and distant metastasis in advanced thoracic malignancies.” Journal of American College of Surgeons. (Surgical Forum), 2009.
  9. White B, Raza SH, Kaddi C, Mancini M, Mohs A, Nie S, Wang MD, Singhal S. “The development of a novel endoscope to visualize residual tumor cells following cancer surgery.” Journal of American College of Surgeons. 209(3):S32-33, 2009.
  10. Predina J. Aliperti L. Kapoor V. Ridge N. Albelda SM. Singhal S. “Modulation of cancer immunobiology to prevent recurrences following surgery for non-small cell lung cancer.” Journal of American College of Surgeons. 211(3):S36-37, 2010.
  11. Predina J, Kotloff, Miller, Singhal S. “Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-Dubé syndrome.” European Journal of Cardio-thoracic Surgery. 39: 404-406, 2011.
  12. Judy B. Predina J. Mittal J. Deshpande C. Singhal S. “Metastatic primary pulmonary angiosarcoma.” Surgical Science. 2:130-132, 2011.
  13. Predina JD, Aliperti LA, Kapoor V, Nakagawa H, Rustgi AK, Cooper JD, Aguilar-Cordova E, Singhal S. “Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Oesophageal Carcinoma.” Interactive Cardiovascular and Thoracic Surgery. 2011 Sept; 11(S3):18.
  14. Predina JD, Anolik RB, Judy B, Akers S, Freiman D, Ahmad D, Singhal S. “Intramural Esophageal Dissection in a Young Man with Eosinophilic Esophagitis.” Ann Thoracic and Cardiovascular Surgery. 18(1):31-5, Sept 29, 2012.
  15. Georgoff P. Singhal S. “Multi-vessel intralobar pulmonary sequestration.” The Annals of Thoracic Surgery.  93(4):1318, Apr 2012.
  16. Judy B, Singhal S. “How can cytoreduction surgery improve the prospects for cancer patients receiving immunotherapy?”  Immunotherapy. 4(11):1077-80, Nov 2012.
 
Awards and Honors
1990 Phi Beta Kappa Book Award
 
1993 Rufus Choate Scholar. Dartmouth College (Academic top 5% class)
 
1994 Magna Cum Laude. Dartmouth College
 
1995 James Ewing Foundation. Medical Student Research Fellowship
 
1995 Lucy Wortham James Research Award. The Society of Surgical Oncology
 
2002 Best Poster Award. Eunice and Irving Annual Scientific Symposium. University of Pennsylvania
 
2002 Mesothelioma Travel Grant Award. Benjamin P. Shein Foundation for Humanity
 
2003 Best Poster Award. University of Pennsylvania Cancer Center Scientific Symposium
 
2003 C. Walton Lillehei Resident Award. American Association for Thoracic Surgery
 
2004 Resident Research Award. Baltimore Academy of Surgery
 
2005 George D. Zuidema Research Award. Johns Hopkins Hospital Department of Surgery
 
2006 Resident Traveling Fellowship. American Association for Thoracic Surgery
 
2008 Thomas B. McCabe and Jeanette Laws McCabe Research Fellowship Award
 
2009 Paul Calabresi Scholar, National Institutes of Health
 
2010 Clinical Scholar Award. Society of University Surgeons
 
2010 American Cancer Society Institutional Research Grant Award Recipient
 
2011 Young Investigator Award. National Lung Cancer Partnership
 
2011 Fellow, American College of Surgeons
 
2011 Clinical Investigator Award.  Society of Surgical Oncology
 
2011 Who’s Who in Medicine and Healthcare, Marquis Who’sWho Publications
 
2011 Fellowship Award.  American Surgical Association
 
2012 OneBreath Clinical Research Award in Lung Cancer. CHEST Foundation

Dr. Singhal Sunil

 
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