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Hansell H. Stedman, M.D.
Gastrointestinal Surgery

 
  • Profile Home
  • Appointments
  • Education
  • Memberships
  • Research
  • Publications

Administrative Office:
BRB II/III Building, Room 608
421 Currie Boulevard
Philadelphia, PA 19104
Administrative Telephone:
215-898-1432
Administrative Fax:
215-573-8606

Clinical Offices:
Philadelphia Veterans
Administration Medical Center
Administrative Telephone: 215-823-5880

Contact Information (internal use only)

hstedman@mail.med.upenn.edu

 

Research Interests

  • Genetics & Comparative Genomics – Contractile Proteins
  • Integrative Biology –Skeletal & Cardiac Muscle
  • Pathobiology & Therapy – Muscular Dystrophy & Cardiomyopathy
  • Vascular Approaches to Systemic Gene Delivery
 
Faculty Appointments
1985 - 1986 Assistant Instructor in Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1989 - 1990 Research Associate, Department of Pathobiology School of Veterinary Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
1990 - 1991 Research Assistant Professor of Surgery
University of Pennsylvania, School of Medicine
Philadelphia, Pennsylvania
 
1991 - 1993 Assistant Instructor in Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1993 - 1994 Instructor in Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1994 - 2003 Assistant Professor of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2003 - present Associate Professor of Surgery
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
1994 - present Director, Muscular Dystrophy Research Institute for Human Gene Therapy
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1994 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1994 - present Attending Surgeon, Veterans Affairs Medical Center
Philadelphia, Pennsylvania
 
2002 - present Ad Hoc Reviewer of Grants for Medical Biochemistry and Skeletal Muscle Biology study sections and Special Emphasis Panel study section, National Institutes of Health
Bethesda, Maryland
 
Education/Training
1975 - 1979 B. S. Massachusetts Institute of Technology
(Chemistry and Biology)
 
1979 - 1984 M. D. Harvard Medical School
 
Postgraduate Training and Fellowship Appointments
1984 - 1985 Intern in Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1985 - 1986 Resident in Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
1986 - 1987 Post Doctoral Fellow
Harrison Department of Surgical Research
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
1987 - 1989 Post Doctoral Fellow, Departments of Human Genetics
Cell & Developmental Biology, and Pathobiology
University of Pennsylvania
Philadelphia, Pennsylvania
 
1991 - 1994 Resident in Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Memberships/Societies
 
National and International Societies
  • 1995-present The New York Academy of Sciences, Active Membership
  • 1996-present Association for Academic Surgery, Active Membership
  • 1997-present American Society for Biochemistry and Molecular Biology
  • 1997-present American Society of Gene (& Cell) Therapy
  • 1997-present Fellow, American College of Surgeons
 
Scientific Committees
  • 2005 Appointed to NINDS (NIH) Muscular Dystrophy Scientific Working Group
 
Research
  Current Research
Current Grant Support
2009 - 2014 Systemic Molecular Therapy for Muscular Dystrophy
 
2005 - 2010 Gene Therapy for Hemophilia
 
2007 - 2012 Translational Program for Molecular Therapeutics in DMD
 
2008 - 2010 Training Grant for Mihail Petrov, M.D.
(postdoctoral fellow)
 
Past Grant Support
2008 - 2009 Translational Program for Molecular Therapeutics in DMD
 
2008 - 2009 Gene Therapy for Hemophilia
 
2003 - 2005 Training Grant for Kapil Gopal, M.D. (postdoctoral fellow)
 
2002 - 2007 Surgical Approaches to Systemic Gene Transfer
 
2002 - 2004 Development of a Platform Technology for Highly Efficient Gene Transfer to the Heart: Application to the Treatment of Heart Failure
 
2002 - 2003 Development of a Platform Technology for Highly Efficient Gene Transfer to the Heart: Application to the Treatment of Heart Failure
 
2001 - 2004 Adaptation of Respiratory Muscle to Emphysema and Lung Volume Reduction
 
2001 - 2004 Systemic Gene Therapy for Inherited Muscle Disease
 
2000 - 2001 Systemic Gene Delivery for Duchenne and Limb-Girdle Muscular Dystrophy
 
1999 - 2000 Gene Therapy for Neuromuscular Disorders
 
1999 - 2002 Systemic Use of Nonimmunogenic Vectors for Gene Therapy in Muscular Dystrophy
 
1999 - 2001 Pre-Clinical Trials of Gene Transfer in the Treatment of End Stage Limb Ischemia
 
1999 - 2000 Nonimmunogenic Vectors for Gene Therapy in Muscular Dystrophy
 
1999 - 2004 Training in Muscle Biology
 
1999 - 2000 Molecular and Clinical Characterization of Individuals with Limb-Girdle Muscular Dystrophy
 
1998 - 2003 Gene Therapy Training: CF and Genetic Diseases
 
1998 - 1999 Gene Therapy for Duchenne and Limb-Girdle Muscular Dystrophy
 
1998 - 1999 Evaluation of Efficacy Following Gene Transfer in Limb-Girdle Muscular Dystrophy
 
1997 - 1999 Gene Therapy for Genetic Diseases: French-Penn Venture
 
1997 Control of ARDS Induced by Fibrosis and Genetic Diseases
 
1996 Can Muscular Dystrophy Be Reversed with Existing Genetic Therapies?
 
1995 - 2001 Gene Therapy for Duchenne Muscular Dystrophy
 
1994 - 1996 Gene Therapy for Cystic Fibrosis and Genetic Diseases
 
Publications
 
Research Publications, Peer-Reviewed
  1. Stedman H, Browning K, Oliver N, Oronzi-Scott M, Fischbeck K, Sarkar S, Sylvester J, Schmickel R, Wang K. Nebulin cDNAs detect a 25 kilobase transcript in skeletal muscle and localize to human chromosome two. Genomics 2(1):1-7, Jan. 1988.
  2. Oronzi-Scott M, Sylvester JE, Heiman-Patterson T, Shi Y-J, Fieles W, Stedman H, Burghes A, Ray P, Worton R, Fischbeck KH. Duchenne muscular dystrophy gene expression in normal and diseased human muscle. Science 239(4846):1418-1420, Mar. 18, 1988.
  3. Cooper BJ, Winand NJ, Stedman HH, Valentine BA, Hoffman EP, Kunkel LM, Oronzi-Scott M, Fischbeck K, Kornegay J, Williams JR, Sylvester JE. The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs. Nature 334(6178):154-156, July 14, 1988.
  4. Eller M, Stedman HH, Sylvester JE, Fertels SH, Rubinstein NA, Kelly AM, Sarkar S. Nucleotide sequence of full length human embryonic myosin heavy chain cDNA. Nucleic Acids Research 17(9):3591-3592, May 11, 1989.
  5. Stedman H, Sylvester J, Pette D, Giger U. Establishment of canine M-type PFK deficiency as a mo-del for the study of somatic cell gene replacement therapy. Journal of Cellular Biochemistry 13B:174, 1989.
  6. Eller M, Stedman HH, Sylvester JE, Fertels SH, Rubinstein NA, Kelly AM, Sarkar S. Human embryonic myosin heavy chain cDNA: Interspecies sequence conservation of the myosin rod, chromo-somal locus and isoform specific transcription of the gene. FEBS Letters 256(1-2):21-28, Oct. 9, 1989.
  7. Stedman HH, Eller M, Jullian EH, Fertels SH, Sarkar S, Sylvester JE, Kelly AM, Rubinstein NA. The human embryonic myosin heavy chain: Complete structure reveals evolutionary relationships with other developmental isoforms. Journal of Biological Chemistry 265(6):3568-3576, Feb. 25, 1990.
  8. Stedman HH, Kelly AM, Rubinstein NA. Isoform-specific cDNAs for human embryonic, neonatal, and slow skeletal myosin heavy chains. Annals of the New York Academy of Science 599:119-126, 1990.
  9. Stedman HH, Sweeney HL, Shrager JB, Maguire HC, Panettierri RA, Narusawa M, Leferovich JM, Sladky JT, Kelly AM. The mdx mouse diaphragm reproduces the degenera-tive changes of Duchenne muscular dystrophy. Nature 352(6335):536-539, Aug. 8, 1991.
  10. Shrager JB, Naji A, Kelly AM, Stedman HH. A PCR-based assay for the wild-type dystro-phin gene transferred into the mdx mouse. Muscle & Nerve 15(10):1133-1137, Oct. 1992.
  11. Giger U, Smith BF, Woods CB, Patterson DF, Stedman H. Inherited phosphofructokinase defi-ciency in an American cocker spaniel. Journal of the American Veterinary Medicine Association 201(10):1569-1571, Nov. 15, 1992.
  12. Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL. Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proceedings of the National Academy of Sciences USA 90(8):3710-3714, Apr. 15, 1993.
  13. Petrof BJ, Stedman HH, Shrager JB, Eby J, Sweeney HL, Kelly AM. Adaptations in myosin heavy chain expression and contractile function in the mdx mouse diaphragm. American Journal of Physiology 265(3 Pt 1): 834-841, Sept. 1993.
  14. Sarkar S, Stedman H, Du Y, Prakash, KJ, Zheng ZC. The cytoplasmic translation inhibitory RNA species of chick embryonic muscle: Correlation of biological activity with secondary structure. Biochemistry (Life Sci. Adv.) 12:109-120, 1993.
  15. Stedman HH, Carpenter JP, Shlansky-Goldberg RD. (1994) Percutaneous balloon catheter vascular control for infected axillary artery pseudoaneurysm. Journal of Cardiovascular Surgery 35(6):529-531, Dec. 1994.
  16. Jullian EH, Kelly AM, Hoffman R, Pompidou AJ, Schiaffino S, Stedman HH, Rubinstein NA. Characterization of a human perinatal myosin heavy-chain transcript. European Journal of Biochemistry 230(3):1001-1006, June 15, 1995.
  17. Smith BF, Henthorn PS, Rajpurohit Y, Stedman H, Wolfe JH, Patterson DF, Giger U. A cDNA encoding muscle-type phosphofructokinase. Gene 168(2):275-276, Feb. 12, 1996.
  18. Wang K, Knipfer M, Huang QQ, van Heerden A, Hsu LC, Gutierre G, Quian XL, Stedman H. Human skeletal muscle nebulin sequence encodes a blueprint for thin filament architec-ture: Sequence motifs and affinity profiles of tandem repeats and terminal SH3. Journal of Biological Chemistry 271(8):4304-4314, Feb. 23, 1996.
  19. Smith BF, Stedman HH, Rajpurohit Y, Henthorn PS, Wolfe JH, Patterson DF, Giger U. Molecular basis of canine muscle-type phosphofructokinase deficiency. Journal of Biological Chemistry 271(33): 20070-20074, Aug. 16, 1996.
  20. Ehlen-Haecker S, Stedman HH, Balice-Gordon RJ, Smith DBJ, Greelish JP, Mitchell MA, Wells A, Sweeney HL, Wilson JM. In vivo expression of full length dystrophin from adeno-viral vectors deleted of all viral genes. Human Gene Therapy 7(15):1907-1914, Oct. 1, 1996.
  21. Chowrashi PK, Pemrick SM, Li S, Yi P, Clarke T, Maguire B, Ader G, Saintigny P, Mittal B, Tewari M, Stoeckert C, Stedman HH, Sylvester JE, Pepe FA. The myosin filament XV assembly: Contribu-tions of 195 residue segments of the myosin rod and the eight C-terminal residues. Journal of Muscle Research & Cell Motility 17(5):555-573, Oct. 1996.
  22. Greelish JP, Su LT, Lankford EB, Burkman, JM, Chen H, Konig SK, Mercier IM, Desjardins PR, Mitchell MA, Zheng XG, Leferovich J, Gao GP, Balice-Gordon RJ, Wilson JM, Stedman HH. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nature Medicine 5(4):439-443, Apr. 1999. (Cover Photo)
  23. Stedman H, Mendell J, Wilson JM, Finkle R, Kleckner AL. Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: Alpha, beta, gamma or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors. Human Gene Therapy 11:777-790, Mar. 20, 2000.
  24. Shrager JB, Desjardins PR, Burkman JM, Konig SK, Stewart DR, Su L, Shar MC, Tewari M, Hoffman R, Rickels MR, Jullian EH, Rubinstein NA, Stedman HH. Human skeletal myosin heavy chain genes are tightly linked in the order embryonic-IIa-IId/x-IIb-perinatal-extracocu-lar. Journal of Muscle Research & Cell Motility 21(4):345-355, May 2000.
  25. Shrager JB, Kim DK, Hashmi YJ, Lankford EB, Wahl P, Stedman HH, Levine S, Kaiser LR. Lung volume reduction surgery restores the normal diaphragmatic length-tension relationship in emphysematous rats. Journal of Thoracic & Cardiovascular Surgery 21(2):217-24, Feb. 1, 2001.
  26. Shrager JB, Kim DK, Hashmi YJ, Stedman HH, Kaiser LR, Levine S. Sarcomeres are added in series to emphasematous rat diaphragm. Chest 121 (3): 831-5 Mar. 2002.
  27. Dejardins P, Burkman J, Shrager J, Allmond L, Stedman H. Evolutionary implications of three novel members of the human sarcomaric myosin heavy chain gene family. Molecular Biology & Evolution 19(4): 375-93 Apr. 2002.
  28. Bridges CR, Burkman JM, Malekan R, Konig SK, Chen H, Yarnell CB, Gardner TJ, Stewart AS, Stecker M, Patterson T, Stedman HH. Global cardiac-specific transgene expression using cardiopulmonary bypass with cardiac isolation. Annals of Thoracic Surgery 73(6):1939-1946, June 2002.
  29. Konig S, Burkman J, Fitzgerald J, Mitchell M, Su L, Stedman H. Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family. Journal of Biological Chemistry 277(31):27593-27605, Aug. 2, 2002.
  30. Kim DK, Zhu J, Kozyak BW, Burkman JM, Rubinstein NA, Lankford EB, Stedman HH, Nguyen T, Levine S, Shrager JB. Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema. Respiratory Research 4:1, 2003.
  31. Krupnick AS, Zhu J, Nguyen T, Kreisel1 D, Balsara1 KR, Lankford EB, Clark CC, Levine S, Stedman HH, Shrager JB. Inspiratory loading does not accelerate dystrophy in the mdx mouse diaphragm: Implications for regenerative therapy. Journal of Applied Physics 94(2):411-419, Feb. 2003.
  32. Stedman HH, Kozyak BW, Nelson A, Thesier DM, Su LT, Low DW, Bridges CR, Shrager JB, Minugh-Purvis N, & Mitchell MA. Myosin gene mutation correlates with anatomical changes in the human lineage. Nature 428:415-419, 2004. (Cover photograph and News & Views Feature).
  33. Arruda VR*, Stedman HH*, Nichols TC, Haskins ME, Nicholson M, Herzog RW, Couto LB, High KA. Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model. Blood 105(9):3458-3464, May 1, 2005. * The first two authors contributed equally
  34. Su LT, Gopal K, Wang Z, Yin X, Nelson A, Kozyak BW, Burkman JM, Mitchell MA, Low DW, Bridges CR, Stedman HH. Uniform scale-independent gene transfer to striated muscle after transvenular extravasation of vector. Circulation 112(12):1780-1788, Sept. 20, 2005.
  35. Bridges CR, Gopal K, , Holt D, Yarnell C, Cole S, Anderson, RB, Yin X, Nelson A, Kozyak BW, Wang Z, Lesniewski J, Su LT, Thesier DM, Sundar H, Stedman HH. Efficient myocyte gene delivery with complete cardiac surgical isolation in situ. Journal of Thoracic & Cardiovascular Surgery 130(5):1364, Nov. 2005.
  36. Moore SA, Shilling CJ, Westra S, Wall C, Wicklund MP, Stolle C, Brown CA, Michele DE, Piccolo F, Winder TL, Stence A, Barresi R, King N, King W, Florence J, Campbell KP, Fenichel GM, Stedman HH, Kissel JT, Griggs RC, Pandya S, Mathews KD, Pestronk A, Serrano C, Darvish D, Mendell JR. Limb-girdle muscular dystrophy in the United States. Journal of Neuropathology & Experimental Neurology 65(10):995-1003, Oct. 2006.
  37. Toromanoff A, Cherel Y, Guilbaud M, Penaud-Budloo M, Snyder RO, Haskins ME, Deschamps JY, Guigand L, Podevin G, Arruda VR, High KA, Stedman HH, Rolling F, Anegon I, Moullier P, Le Guiner C. Safety and efficacy of regional intravenous (r.i.) versus intramuscular (i.m.) delivery of rAAV1 and rAAV8 to nonhuman primate skeletal muscle. Molecular Therapy: the Journal of the American Society of Gene Therapy 16(7):1291-1299, July 2008.
Reviews in Peer-Reviewed Research Publications
  1. Stedman H, Sarkar S. Molecular genetics in basic myology: A rapidly evolving perspective. [Review] Muscle & Nerve 11(7):668-693, July 1988.
  2. Stedman H, Sarkar S. Molecular genetics in muscular dystrophy research: revolutionary progress. [Review] Muscle & Nerve 11(7):694-704, July 1988.
  3. Stedman HH. Molecular approaches to therapy for Duchenne and limb-girdle muscular dystrophy. [Review] Current Opinion in Molecular Therapy 3(4):350-356, Aug. 1, 2001.
Contributions to Peer-Reviewed Clinical Research Publications, Participation Cited but not by Authorship
  1. Stedman HH, Kozyak BW, Nelson A, Thesier DM, Su LT, Low DW, Bridges CR, Shrager JB, Minugh-Purvis N, & Mitchell MA. Myosin gene mutation correlates with anatomical changes in the human lineage. Nature 428:415-419, 2004. (Cover photograph and News & Views Feature). also featured in Science magazine editorial: Pennisi, E. The Primate Bite: Brawn Versus Brain? Science 2004 303:1957.
Abstracts (Past 3 Years)
  1. White J, Thesier DM, Swain JD, Katz MG, Henderson A, Yarnall C, Isidro A, Chen H, Petrov M, Holt D, Nolen-Walston R, Stedman HH, Rabinowitz J, Bridges CR. Adeno-associated viral vector-mediated gene transfer to the heart using molecular cardiac surgery: A novel translatable closed recirculation system for myocardial gene delivery. British Society of Gene Therapy, 2009.
  2. Cheng CP, Cheng HJ, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK. Cardiomyopathy in a canine model of Duchenne muscular dystrophy: Effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation. Circulation 120(Suppl 2): S667, 2009. American Heart Association Scientific Assembly, 2009.
  3. Swain JD, Katz MG, Fargnoli A, White J, Thesier DM, Yarnall C, Isidro A, Petrov M, Holt D, Nolen-Walston R, Stedman H, Koch WJ, Pilla JJ, Rabinowitz J, Bridges CR. Improved myocardial mechanics after GRK2 inhibition using molecular cardiac surgery with recirculating delivery (MCARDTM) to deliver AAV6-bARKct in sheep. American Heart Association Scientific Assembly, 2009.
  4. Swain JD, Katz MG, Fargnoli A, Yarnall C, Stedman HH, Rabinowitz J, Bridges CR. Molecular cardiac surgery with recirculating delivery (MCARDTM): Cardiac specificity of the closed retrograde coronary recirculation method of gene delivery using cardiopulmonary bypass with adeno-associated viral vectors in the ovine model. American Association for Thoracic Surgery, 2010.
  5. Swain JD, Katz MG, Fargnoli A, Sumaroka M, Tomasulo C, Petrov M, Pilla JJ, Stedman HH, Koch WJ, Rabinowitz J, Bridges CR. In vivo over expression of beta-adrenergic receptor kinase inhibitor using scAAV6-mediated molecular cardiac surgery with recirculating delivery (MCARD) enhances cardiac function. American Society of Gene & Cell Therapy, 2010.
  6. Malik A, Xu A, Chen J, Mead A, Childers M, Bogan J, Schatzberg S, Kornegay J, Stedman H. Detailed physical mapping of deletion breakpoints in the GSHP dog model for DMD. American Society of Gene & Cell Therapy, 2010.
  7. Malik A, Mitchell M, Mead A, Petrov M, Stedman H. Optimization of AAV vectors for improved therapeutic protein expression in the canine models for Duchenne Muscular Dystrophy. American Society of Gene & Cell Therapy, 2010.
  8. Mead A, Malik A, Petrov M, Childers M, Bogan J, Kornegay J, Stedman H. External, non-invasive monitoring of progressive cardiorespiratory dysfunction in a canine model of DMD. American Society of Gene & Cell Therapy, 2010.
  9. Mead A, Malik A, Petrov M, Childers M, Mitchell M, Bogan J, Kornegay J, Nickens B, Stedman H. High force myosin correlated with the early degeneration of jaw closing muscle in the GRMD model of DMD. American Society of Gene & Cell Therapy, 2010.
  10. Petrov M, Mitchell M, Malik A, Mead A, Balzer F, Su L, Farag J, Kozyak B, Gopal K, Bridges C, Bogan J, Childers M, Kornegay J, Stedman H. First generation AAV microutrophin vector infused into the isolated pelvic limb of a canine model for Duchenne Muscular Dystrophy. American Society of Gene & Cell Therapy, 2010.
  11. Balzer F, Farag J, Malik A, Petrov M, Mead A, Kozyak B, Gopal K, Mitchell M, Choi C, Chen J, Low D, Yarnall C, Bridges C, Stedman H. Reverse perfusion affords efficient whole-body gene transfer to muscle in the large animal. American Society of Gene & Cell Therapy, 2010.
Editorials, Chapters and Participation in Committee Reports
  1. Dasgupta S, Eller MS, Zolnay S, Jayabaskaran C, Stedman H, Sarkar S. Cytoplasmic translation inhibitory RNA of chick embryonic muscle: possible role in myogenesis as antimes¬senger RNA. In Emerson C, Fischman D, Nadal-Ginard B and Siddiqui M (eds). Molecular Biology of Muscle Develop¬ment/ UCLA Symposium on Molecular and Cellular Biology, Vol. 29. New York: Alan R. Liss, Inc, 1986, 591-603.
  2. Stedman H, Browning K, Qian X, Oliver N, Oronzi-Scott M, Fischbeck K, Sarkar S, Sylvester J, Schmickel R, Wang K. Characterization of the human nebulin locus and its 25 kb transcript: progress towards a full length cDNA. In Stockdale F and L Kedes (eds): Cellular and Molecular Biology of Muscle Development/ UCLA Symposia on Molecular and Cellular Biology, Vol. 93. New York: Alan R. Liss, Inc., 1989, 181-196.
  3. Sarkar S, Eller MS, Raychowdhury MK, Stedman H, Wu QL. The cytoplasmic translation inhibitory RNA of chick embryonic muscle: resolution of multiple biologically active subspecies and mechanism of action. In Stockdale F and L Kedes (eds): Cellular and Molecular Biology of Muscle Development/ UCLA Symposia on Molecular and Cellular Biology, Vol. 93. New York: Alan R. Liss, Inc., 1989, 555-570.
  4. Shrager JB, Stedman HH, Sweeney HL, Petrof B, Kelly AM. The mdx mouse and the mdx diaphragm: Implications for the pathogenesis of Duchenne muscular dystrophy. In Kelly, AM and HM Blau (eds): Neuromuscular Development and Disease. New York: Raven Press, 1992, 317-328.
  5. Su L, Stedman H. Systemic delivery approaches. In Chamberlain J, Rando T (eds): Duchenne Muscular Dystrophy: Advances in Therapeutics. New York: Taylor & Francis Group, LLC, 2006, 439-449.
  6. Petrov M, Malik A, Mead A, Bridges C, Stedman H. Crossing the endothelial barrier: Gene transfer from the isolated regional circulation. In Duan D (ed): Muscle Gene Therapy: Methods and Protocols. New York: Humana Press, Inc., 2010 (in press).
Alternative Media
  1. Stedman H. Clinical teaching in general and vascular surgery. Case Studies in Clinical Surgery. Multimedia Tool for Interactive Use in Academic Surgery (CD-ROM and DVD Digital Photographs and Movies), 2002.
  2. Stedman H. Complex surgical procedures in the research laboratory. Case Studies in Clinical Surgery. Multimedia Tool for Interactive Use in Academic Surgery (CD-ROM and DVD Digital Photographs and Movies), 2002.
  3. Carroll S. Evolution: Constant Change and Common Threads. 2005 Howard Hughes Medical Institute, Chevy Chase, MD, Live and Online Biointeractive Lecture Series, #4. Dr. Carroll makes extensive use of Stedman Lab data, with permission, to illustrate key points in research on human evolution. Also distributed on DVD from HHMI. (link)
  4. Lemonick M, Dorfman A. What makes us different? Not very much, when you look at our DNA. But those few tiny changes made all the difference in the world. Time Magazine Oct. 1, 2006. Section of article recounting context of the laboratory’s findings as originally presented in Stedman, et al, 2004 428:415-419, Nature.
  5. Stedman H. The Human Ape. National Geographic TV Documentary, Broadcast March 2008. Dr. Stedman and other members of the Stedman Lab featured in segment providing context for Stedman, et al, 2004 428:415-419, Nature. Also distributed on DVD from National Geographic.
  6. Stedman H. How to Build a Better Being. National Geographic TV Documentary, Broadcast Sept. 2008 Dr. Stedman and other members of the Stedman Lab featured in segment providing context for Stedman, et al, 2004 428:415-419, Nature. and ongoing work. Also distributed on DVD from National Geographic
  7. Stedman H. What Darwin Never Knew. NOVA TV Documentary, Broadcast Dec. 2009. Dr. Stedman and members of the Stedman Lab featured in segment providing context for Stedman, et al, 2004 428:415-419, Nature. and ongoing work. Includes extensive coverage of interview on muscle biology in UPenn’s Pottruck Health and Fitness Center. Also distributed on DVD from NOVA.
Patents
  1. Stedman H. Compositions, methods and apparatus for delivery of a macromolecular assembly to an extravascular tissue of an animal. U.S. Patent 6,177,403 B1, issued Jan. 23, 2001 (44 claims).
  2. Bridges C, Stedman H. Compositions, kits, methods, and apparatus for transvascular delivery of a composition to an extravascular tissue of a mammal. U.S. Patent 6,673,039, Issued Jan. 4, 2004.
  3. Stedman H, Wilson J. Stable protection from dystrophic sarcoleminal degeneration and restoration of the sarcoglycan complex. International Patent Application PCT/US99/04367 (WO 99/43360).
  4. Stedman H, Bridges C. Transvascular delivery of a composition to an extravascular tissue of a mammal. International Patent Application PCT/US98/27072 (WO 99/31982).
  5. Stedman H, Bridges C. Methods, compositions, and apparatus for delivering heterologous molecules to cells. U.S. Patent Application 10/573,129
  6. Stedman H, Bridges C, Gopal K. Global myocardial perfusion catheter. U.S. Patent Application 10/572,238.
  7. Stedman H, Mitchell M, Su L. Microutrophin and uses thereof. U.S. Patent Application 10/586,890.

Dr. Hansell Stedman

 
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