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Julia C. Tchou, M.D., Ph.D.
Endocrine and Oncology Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
4 Silverstein Pavilion
Philadelphia, PA 19104
Administrative Assistant: Rachel Thomas
Administrative Telephone: 215-615-7575
Administrative Fax: 215-615-0555
Patient Appointments: 215-662-7900

Clinical Offices:
Perelman Center for Advanced Medicine
Rena Rowan Breast Center
Abramson Cancer Center
3rd Floor West
3400 Civic Center Boulevard
Philadelphia, PA 19104

Contact Information (internal use only)

julia.tchou@uphs.upenn.edu

 

Breast cancer surgeon Julia C. Tchou, MD, PhD, has joined the Abramson Cancer Center of the University of Pennsylvania, where she will also hold an appointment as Assistant Professor of Surgery at Penn’s School of Medicine. Prior to coming to Penn, she completed a breast surgery fellowship at Northwestern Memorial Hospital in Chicago, Illinois.

Based at the Cancer Center’s Rena Rowan Breast Center, Tchou’s practice focuses exclusively on the interdisciplinary management of patients with breast cancer: coordinating pre-operative evaluation, surgery and post-operative care of women with benign and malignant breast diseases. Her research focuses on the breast cancer tumor microenvironment, cancer stem cell biology, and development of new therapeutic targets for breast cancer. Tchou has published several studies on various aspects of cancer in leading, peer-reviewed journals such as Proceedings of the National Academy of Sciences, Biochemistry, the Journal of Biological Chemistry, the International Journal of Oncology, and the British Journal of Radiology.

Tchou completed her general surgery residency training from 1995 to 2001 at Johns Hopkins Hospital in Baltimore, Maryland before taking on a position as assistant chief of surgery service at Johns Hopkins Hospital from 2001 to 2002. Prior to this, she completed her doctoral studies and medical training as part of the Medical Scientist Training Program, at the State University of New

York (SUNY) in Stony Brook, New York, from 1987 to 1995, where she also received numerous honors for academic excellence. Tchou earned her undergraduate science degree in biochemistry from the College of Mount Saint Vincent in Riverdale, New York, in 1987.

 
Faculty Appointments
2001 - 2002 General Surgery Instructor
Johns Hopkins School of Medicine
Baltimore, Maryland
 
2003 - present Assistant Professor of Surgery at HUP
University of Pennsylvania
Philadelphia, Pennsylvania
 
2007 - present Course Director, Breast Surgery Elective
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2007 - present Assistant Program Director, Breast Fellowship
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2009 - present Adjunct Faculty, The Wistar Institute
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2001 - 2002 Assistant Chief of General Surgery Service
Johns Hopkins Hospital, Baltimore, Maryland
 
2004 - 2009 Staff Surgeon, Veterans Affairs Medical Center
Philadelphia, Pennsylvania
 
2003 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Education/Training
1982 - 1987 B.S. College of Mount Saint Vincent
Riverdale, New York
(Biochemistry, Summa Cum Laude)
 
1987 - 1995 M.D. State University of New York at Stony Brook School of Medicine
Stony Brook, New York
 
1989 - 1993 Ph.D. State University of New York at Stony Brook School of Medicine
Stony Brook, New York
(Medical Scientist Training Program)
 
Postgraduate Training and Fellowship Appointments
1995 - 1996 Intern, Johns Hopkins Hospital
Baltimore, Maryland
 
1996 - 1997 Junior Assistant Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
1997 - 1998 Research Fellow, Department of Medical Oncology
Johns Hopkins Hospital, Baltimore, Maryland
 
1998 - 1999 Senior Assistant Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
1999 - 1999 Registrar, John Radcliffe Hospital
Oxford, United Kingdom
 
2000 - 2000 Senior Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
2000 - 2001 Chief Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
2001 - 2002 Fellowship in Gastrointestinal Surgery
Johns Hopkins Hospital, Baltimore, Maryland
 
2002 - 2003 Breast Fellowship Northwestern Memorial Hospital
Chicago, Illinois
 
Memberships/Societies
 
National Scientific Societies
1989 Member, American Associate of Cancer Research 
 
2002 Member, American Society of Clinical Oncology
 
2002 Member, Association of Women Surgeons
 
2003 Member, Society of Surgical Oncology
 
2005 Member, Association of Academic Surgery
 
2011  Fellow, American College of Surgeons
 
National, Regional and Local Scientific Committees
2003 – present Member, Abramson Cancer Center
Perelman School of Medicine at the University of Pennsylvania
 
2009 – present  Member, Tumor Microenivronment and Metastasis Program
The Wistar institute, Philadelphia, Pennsylvania
 
2010 -  present  ECOG Breast Committee's Local-Regional Working Group
 
2010 -  present  Affiliate member, Cancer Center at the Wistar Institute
 
2011 – 2016  Co-director, Developmental Core Program
Penn Transdisciplinary Research on Energetics and Cancer Research Program
 
2013  Scientist Reviewer, DOD, CDRMP, Breast Cancer Research Program
 
2013 - 2014   Program Committee Member, Association of Academic Surgery
 
Research
 

As a physician scientist, my priority is to deliver state-of-the-art care to treat women diagnosed with breast cancer and other breast diseases. My research interest is linked closely to my clinical work. My goals are to translate laboratory discoveries to the bedside and to deliver cutting-edge treatment to women with breast cancer to improve outcome.

My clinical and research interest is focused on the development of novel targeted therapy for invasive breast carcinoma, in particular, triple negative breast cancer (TNBC) which lacks effective targeted therapy. I am also interested in adopting strategies that will harness our own immune response as a therapeutic and prevention strategy against breast cancer. To accomplish these research goals, I have been working closely with tumor immunologists in the laboratory and in the clinic to translate pre-clinical work into clinical trial, adopting the “mouse-to- human” research paradigm.

To this end, in partnership with Dr. Carl H June, a pioneer in cancer immunotherapy in adoptive transfer of autologous chimeric antigen receptor (CAR) T cells to treat patients with refractory chronic lymphocytic leukemia, we have launched a pilot clinical trial in 2013 for patients with metastatic breast cancer to test the safety and efficacy of intratumoral injection of CAR T cells genetically modified to target c-met, a hepatocyte growth factor receptor, which is often overexpressed in TNBC and other breast cancer subtypes.

In addition, I am collaborating with a distinguished Wistar’s tumor immunologist, Dr. Jose Conejo-Garcia, to optimize CAR T cells immunotherapy in mice. We have developed a novel inducible breast tumor model in mice with intact immune response. This novel mouse breast tumor model will allow us to study the impact of tumor microenvironment and immune response during breast cancer development, a research area that is still poorly understood. Our animal model is also particularly useful in predicting adverse effects in CAR T cells immunotherapy and in addressing many clinically relevant questions that will ultimately enhance the efficacy of CAR T cells immunotherapy in the treatment of breast cancer.  

A third component of my research interests is focused on using our electronic medical record (EMR) to address hypothesis-driven and clinically relevant questions. One ongoing project is to investigate the effects of metformin in women with breast cancer. Metformin has been known to reduce breast cancer risk but its mechanism of action is unknown. Our clinical investigation will address some of these mechanisms through our EMR cohort of > 20,000 patients.
 
Publications
 
Research Publications, peer reviewed
  1. Tchou J, Kasai H, Shibutani S, Chung MH, Laval J, Grollman AP, Nishimura S.  8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.  Proceedings of the National Academy of Sciences of the United States of America 88(11):4690-4694, June 1, 1991.
  2. Tchou J, Michaels ML, Miller JH, Grollman AP.  Function of the zinc finger in Escherichia coli Fpg protein.  Journal of Biological Chemistry 268(35):26738-26744, Dec. 15, 1993.
  3. Tchou J, Bodepudi V, Shibutani S, Antoshechkin I, Miller J, Grollman AP, Johnson F.  Substrate specificity of Fpg protein: Recognition and cleavage of oxidatively damaged DNA. Journal of Biological Chemistry 269(21):15318-15324, May 27, 1994.
  4. Tchou J, Grollman AP.  The catalytic mechanism of Fpg protein: Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site.  Journal of Biological Chemistry 270(19):11671-11677, May 12, 1995.
  5. Tchou JC, Lin X, Freije D, Isaacs WB, Brooks JD, Rashid A, De Marzo AM, Kanai Y, Hirohashi S, Nelson WGGSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. International Journal of Oncology 16(4):663-676, Apr. 2000.
  6. Yam M, Tchou J, English R, Highnam R, Highnam R, Roskell D, Greenall M, Brady M.  A mammographic dilemma: Calcification or haemosiderin as a cause of opacities? Validation of a new digital diagnostic tool.  British Journal of Radiology 74(887):1048-1051, Nov. 2001.
  7. Tchou J, Hou N, Rademaker A, Jordan VC, Morrow M.  Acceptance of tamoxifen chemo-prevention by physicians and women at risk.  Cancer 100(9):1800-1806, May 1, 2004.
  8. Durduran T, Choe R, Yu G, Zhou C, Tchou JC, Czerniecki BJ, Yodh AG. Diffuse optical measurement of blood flow in breast tumors. Optics Letter 30, 2915-2917, 2005.
  9. Vapiwala N, Starzyk J, Harris EE, Tchou JC, Boraas MC, Czerniecki BJ, Rosato EF, Orel SG, Solin LJ: Biopsy findings after breast conservation therapy for early-stage invasive breast cancer. International Journal of Radiation Oncology Biology Physics 2007, 69(2): 490-497.
  10. Tchou J, Ward MR, Volpe P, Palma MD, Medina CA, Sargen M, Sonnad SS, Godwin AK, DalyM, Winchester DJ et al: Large genomic rearrangement in BRCA 1 and BRCA 2 and clinical characteristics of men with breast cancer in the United States.  Clin Breast Cancer. 2007 Jun;7(8):627-33.
  11. Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A: Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters : a potentially useful method for disease characterization.  Cancer 2008 Mar 1;112(5):995-1000.
  12. Weinstein SP, Orel SG, Pinnamaneni N, Tchou J, Czerniecki B, Boraas M, Rosato E, Solin LJ: Mammographic appearance of recurrent breast cancer after breast conservation therapy.  Acad Radiol 2008, 15(2):240-244.
  13. Tchou J, Greshock J, Bergey MR, Sonnad SS, Sargen M, Weinstein S, Czerniecki BJ, Boraas M, Fraker DL, Rosato E et al: Method of primary tumor detection as a risk factor for local and distant recurrence after breast-conservation treatment for early-stage breast cancer.  Clinical Breast Cancer 2008, 8(2):143-148.
  14. Choe R, Konecky SD, Corlu A, Lee K, Durduran T, Busch DR, Pathak S, Czerniecki BJ, Tchou J, Fraker DL, Demichele A, Chance B, Arridge SR, Schweiger M, Culver JP, Schnall MD, Putt ME, Rosen MA, Yodh AG. Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography. J Biomed Opt. 2009 Mar-Apr;14(2):024020.
  15. Tchou J, Sonnad S, Bergey MR, Basu S, Tomaszewski J, Alavi A, Schnall M: Degree of tumor FDG uptake correlates with proliferation index in triple negative breast cancer.Mol Imaging Biol. 2010 Dec;12(6):657-62.
  16. Busch DR, Guo W, Choe R, Durduran T, Feldman MD, Mies C, Rosen MA, Schnall MD, Czerniecki BJ, Tchou J, DeMichele A, Putt ME, Yodh AG:  Computer aided automatic detection of malignant lesions in diffuse optical mammography.  Med Phys. 2010 Apr;37(4):1840-9.
  17. Mislowsky A, Domchek S, Stroede C, Bergey M, Sonnad S, Wu L, Tchou J:  Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation screening  - A retrospective cohort analysis of 158 mutation carriers treated at a single institution.  Ann Surg Oncol. 2011 Mar;18(3):745-51.
  18. Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vonderheide RH, Albelda SM, June CH et al: Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat 2012 Jun; 133(2): 799-804.
  19. Nelson JA, Tchou J, Domchek S, Sonnad SS, Serletti JM, Wu LC: Breast reconstruction in bilateral prophylactic mastectomy patients: Factors that influence decision making. J Plast Reconstr Aesthet Surg 2012.
  20. Tchou J, Kossenkov AV, Chang L, Satija C, Herlyn M, Showe LC, Pure E: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. BMC Med Genomics 2012, 5(1):39.
  21. Busch DR, Choe R, Rosen MA, Guo W, Durduran T, Feldman MD, Mies C, Czerniecki BJ, Tchou J, Demichele A, Schnall MD, Yodh AG. Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy. Biomed Opt Express 2013, 4(1): 105-21.
  22. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S et al: The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design. Cancer Causes Control 2013, 24(4):695-704.
  23. Xu HN, Tchou J, Li LZ. Redox imaging of human breast cancer core biopsies: a preliminary investigation. Acad Radiol 2013; 20, 764-768.
  24. Xu HN, Zheng G, Tchou J, Nioka S, Li LZ. Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging. Springerplus 2013; 2, 73.
  25. Zhang Z, Pal S, Bi Y, Tchou J, Davuluri RV. Isoform level expression profiles provide better cancer signatures than gene level expression profiles. Genome Med 2013; 5, 33.
  26. Fracol M, Xu S, Mick R, Fitzpatrick E, Nisenbaum H, Roses R, Fisher C, Tchou J, Fox K, Zhang P, Czerniecki BJ. Response to HER-2 Pulsed DC1 Vaccines is Predicted by Both HER-2 and Estrogen Receptor Expression in DCIS. Ann Surg Oncol 2013.
  27. Gumireddy K, Li A, Yan J, Setoyama T, Johannes GJ, Orom UA, Tchou J, Liu Q, Zhang L, Speicher DW, Calin GA, Huang Q. Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J 2013.
  28. Brown JC, Cheville AL, Tchou JC, Harris SR, Schmitz KH. Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema. Support Care Cancer 2013.
Reviews in Peer-Reviewed Research Publications
  1. Michaels ML, Tchou J, Grollman AP, Miller JH. A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry. 1992 Nov 17;31(45):10964-8.
  2. Tchou J, Grollman AP.  Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine.  Mutation Research 299(3-4):277-287, May 1993.
  3. Grollman AP, Johnson F, Tchou J, Eisenberg M.  Recognition and repair of 8-oxoguanine and formamidopyrimidine lesions in DNA.  Annals of the New York Academy of Sciences 726:208-214, July 29, 1994.
  4. Tchou J, Morrow M.  Available models for breast cancer risk assessment:  How accu-rate are they?  Journal of American College of Surgeons 197(6):1029-1035, Dec. 2003.
  5. Cheville AL, Tchou J Barriers to rehabilitation following surgery for primary breast cancer.. J Surg Oncol. 2007 Apr 1;95(5):409-18.
  6. Nelson JA, Tchou J, Domchek, S, Low DW, Serletti JM, Wu LC: Breast reconstruction – A historical perspective on available techniques for patients electing bilateral mastectomy. Current Cancer Therapy Reviews 2011 Nov: 7(4): 272-281.
  7. Nelson JA, Nelson P, Tchou J, Serletti JM, Wu LC: The ethnic divide in breast reconstruction: A review of the current literature and directions for future research. Cancer Treat Rev 2012, 38(5):362-367.
  8. Lam L, McAndrew N, Yee M, Fu T, Tchou JC, Zhang H: Challenges in the clinical utility of the serum test for HER2 ECD. Biochim Biophys Acta 2012. Aug; 1862(1): 199-208.
  9. Fisher CS, Freedman GM, Tchou J: Can we identify a subset of patients with DCIS that can be treated by wide excision alone? Current Cancer Therapy Reviews 2012, 8(3):177-181.
  10. Tchou J, Conejo-Garcia J: Targeting the tumor stroma as a novel treatment strategy for breast cancer: shifting from the neoplastic cell-centric to a stroma-centric paradigm. Adv Pharmacol 2012, 65:45-61.
  11. Xu HN, Tchou J, Chance B, Li LZ: Imaging the redox states of human breast cancer core biopsies. Adv Exp Med Biol. 2013; 765:343-9.
  12. Cintolo JA, Tchou J, Pryma DA: Diagnostic and prognostic application of positron emission tomography in breast imaging: emerging uses and the role of PET in monitoring treatment response. Breast Cancer Res Treat 2013.
  13. Cubillos-Ruiz J, Rutkowski MR, Tchou J, Conejo-Garcia J: Restoring deleterious immune responses via microRNA modulation. microRNA Diagnostics and Therapeutics 2013, in press.
Grant review by invitation, past 5 years
  1. Developmental Pilot Project Grant review, TREC, 2012
  2. Scientist reviewer, 2012 Breast Cancer Research Program for the United States Department of Defense Congressionally Directed Medical Research Programs.
Abstracts
  1. Tchou J,  Hou N, Rademaker A, Jordan VC, Morrow M.  Acceptance of Tamoxifen (Tam) as Chemoprevention.  Program/Proceedings of the American Society of Clinical Oncology, 2003.
  2. Morrow M, Tchou J, Nakhlis F, Hou N, Rademaker A, Khan S.  Acceptance of Tamoxifen (Tam) Chemoprevention varies with the cause of breast cancer risk.  Program/Proceedings of the American Society of Clinical Oncology, 2003.
  3. Tchou J, Greshock J, Rebbeck T, Weber L and Solin L.  Predicting distant metastasis after local recurrence (failure) in women treated by breast conserving treatment. Abstract no. 1060, 28th annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment 94(1), 2005.
  4. Tchou, J, Ward, R, Volpe, P, Medina, A, Weber, B, Domchek, S and Nathanson, K.  Frequency of BRCA1 and BRCA2 genomic rearrangements and mutations in men with breast cancer: A clinic-based study in the United States, Society of Surgical Oncology Annual Meeting, March 2006.
  5. Tchou J, Sonnad S, Sargen M, Weber B, Nathanson K, Domchek S. Contralateral prophylactic mastectomy in affected carriers of deleterious BRCA1 or BRCA2 mutations:  Does timing of genetic testing matter?  Abstract no. 10512, ASCO Annual Meeting Proceedings, 2006.
  6. Tchou J, Wang LP, Sargen M, Sonnad S, Tomaszewski J, and Schnall M. Do triple-negative breast cancers have a distinct imaging phenotype? Abstract no. 551108, 29th Annual San Antonio Breast Cancer Symposium, 2006.
  7. Tchou J, Sargen M, Sonnad S, Weber BL, Nathanson K, Domchek S. Characteristics of BRCA1 and BRCA2 mutation carriers who chose prophylactic mastectomy. Accepted as Poster Presentation, Society of Surgical Oncology Annual Meeting, March 2007.
  8. Mislowsky A, Domchek S, Stroede C, Bergey MR, Sonnad S, Wu L, and Tchou J. Surgical trends in BRCA1/2 mutation carriers with breast cancer – a single institution experience. Poster presentation, American Society of Breast Surgeons Annual Meeting, Las Vegas, NV, April 28, 2010.
  9. Nelson JA, Domchek SM, Tchou J, Serletti JM, Wu LC. Bilateral prophylactic mastectomy and breast reconstruction: What influences the decision? Presented at the 54th Annual Meeting of the Ohio Valley Society of Plastic Surgeons conjoined with the Ivy Society of Plastic Surgery. White Sulfur Springs, West Virginia, June 2-4 2011.
  10. Karemore G, Hue N, Keller B, Tchou J, Conant E, Kontos D. Computer-aided Parenchymal Texture Analysis in Digital Mammograms: The Potential for Estrogen-Receptor Specific Breast Cancer Risk Estimation. Oral presentation, RSNA 97th Scientific Assembly and Annual Meeting, November 27 – December 2, 2011, McCormick Place, Chicago, Illinois.
  11. Tchou J, Satija C, Zhang P, Bi YT, Chen HY, Majumdar R, Chang L, Davuluri R, Showe L, Mies C, Herlyn M, and Puré E. Significance of FAP, SMA and CD31 expression in the stroma of breast. Poster presentation P1-03-09, CTRC-AACR San Antonio Breast Cancer Symposium, December 7, 2011, San Antonio, Texas.
  12. Tchou J, Wang, L-C, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vonderheide RH, Albelda SM, June CH, Zhang PJ: Mesothelin, a novel immunotherapy target for triple negative breast cancer. Poster and oral presentation X-9, 15th Annual Translational Research Cancer Centers Consortium, Seven Springs, PA.
  13. Tchou J, Kossenkov AV, Chang L, Satija C, Herlyn M, Showe LC, Puré E. Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. Poster Presentation, American Society of Breast Surgeons Annual Meeting, May 2-4, 2012, Phoenix, Arizona.
  14. Xian R, Tchou J, Ziober A, Vonderheide R, June C, Zhang PJ. African American women with breast cancer show higher expression of the targetable cell surface protein Mesothelin. Poster presentation, 102nd United States and Canadian Academy of Pathology Annual Meeting, March 2-8, 2013, Baltimore, MD.
  15. Edwards C, Ky B, Tchou J, Zhang H. Monitoring soluble Her2 extracellular domain in the serum of breast cancer patients using a refined ELISA Assay. Poster Presentation, Society of Surgical Oncology Annual Meeting, March 2013, Washington DC.
  16. Edwards C, Freedman G, Czernieck B, Tchou J, Fisher CS. Evaluation of margin index for prediction of residual disease after breast-conserving surgery: Can it be a useful tool for the breast surgeon? Poster Presentation, American Society of Breast Surgeons Annual Meeting, May 2013, Chicago.
  17. Okusanya OT, Judy B, Venegas O, Quatromoni J, Singhal S, Tchou J. A Novel Technique for Near Infrared (NIR) Intraoperative Imaging of Breast Cancer and Sentinel Lymph Nodes (SLNs). Oral Presentation. American College of Surgeons’ 99th clinical Congress, October 7 2013, Washington DC.
  18. Li Y and Tchou J. Association between metformin use and improved survival in breast cancer patients: a population-based study.  Poster Presentation, San Antonio Breast Cancer Conference, December 2013, San Antonio.
Editorials, Reviews, Chapters
  1. Tchou J, Morrow M.  Overview of clinical risk assessment.  In Morrow M, Jordan VC (eds): Managing Breast Cancer Risk.  Hamilton, Ontario: BC Decker, 2003, pp. 3-25.
  2. Kruper L, Tchou J.  The breast. In Atluri P, Karakousis GC, Porrett PM, Kaiser LR (eds): The Surgical Review. 2nd Edition. Philadelphia, PA: Lippincott Williams & Wilkins, 2006, pp. 502-517.
  3. Solin L, Harris E, Weinstein S, DeMichele A, and Tchou J.  Local-Regional Recurrence after Breast-Conservation Treatment or Mastectomy.  In Harris J, Morrow M, Lippman M, Osborne C (eds): Diseases of the Breast. Fourth Edition.  Philadelphia, Pa: Lippincott Williams & Wilkins, a Wolters Kluwer business, 2010, pp. 840-855.
  4. Tchou J.  Breast Cancer Diagnostic Algorithms for Primary Care Providers.  In Counter Details, Pennsylvania Medical Society, 2010.
  5. Karemore G, Keller B, Oh H, Tchou J, Nielsen M, Conant E, Kontos D. Mammographic parenchymal texture analysis for estrogen-receptor subtype specific breast cancer risk estimation. In Maidment ADA, Bakic PR, Gavenonis S (eds): Proceedings of International Workshop on Breast Imaging (IWDM), Lecture Notes in Computer Science (LNCS). Springer-Verlag Berlin Heidelberg 7361: 596-603, June 2012.
Alternative Media
  1. 2011 - CBS3 TV Interview regarding Z11 trial
  2. 2011 - WHYY radio interview regarding Z11 trial
  3. 2012 - Philadelphia Inquirer featured in an article in 10/18/2012 noting that Julia Tchou as one of the two Penn breast surgeons to perform the most number of mastectomies
Patents
  1. Project title: Genetic Diagnosis of Hepatocellular Carcinoma (Liver Cancer) (JHU Ref. DM-3602); Inventors: William G. Nelson, Xiaohui Lin, Julia C. Tchou, Jila Bakker; U.S. Patent pending, 2003.

Dr. Julia Tchou

 
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