penn medicine
penn surgery
penn surgery home penn surgery clinical penn surgery education penn surgery research penn surgery administration

Julia C. Tchou, MD, PhD
Endocrine and Oncology Surgery

 
  • Profile Home
  • Appointments
  • Education
  • Societies
  • Research
  • Publications
  • Awards

Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
4 Silverstein Pavilion
Philadelphia, PA 19104
Administrative Assistant: Rachel Thomas
Administrative Telephone: 215-615-7575
Administrative Fax: 215-615-0555
Patient Appointments: 215-662-7900

Clinical Offices:
Perelman Center for Advanced Medicine
Rena Rowan Breast Center
Abramson Cancer Center
3rd Floor West
3400 Civic Center Boulevard
Philadelphia, PA 19104

Contact Information (internal use only)

julia.tchou@uphs.upenn.edu

 

Breast cancer surgeon Julia C. Tchou, MD, PhD, has joined the Abramson Cancer Center of the University of Pennsylvania, where she will also hold an appointment as Associate Professor of Surgery at Penn’s School of Medicine. Prior to coming to Penn, she completed a breast surgery fellowship at Northwestern Memorial Hospital in Chicago, Illinois.

Based at the Cancer Center’s Rena Rowan Breast Center, Tchou’s practice focuses exclusively on the interdisciplinary management of patients with breast cancer: coordinating pre-operative evaluation, surgery and post-operative care of women with benign and malignant breast diseases. Her research focuses on the breast cancer tumor microenvironment, cancer stem cell biology, and development of new therapeutic targets for breast cancer. Tchou has published several studies on various aspects of cancer in leading, peer-reviewed journals such as Proceedings of the National Academy of Sciences, Biochemistry, the Journal of Biological Chemistry, the International Journal of Oncology, and the British Journal of Radiology.

Tchou completed her general surgery residency training from 1995 to 2001 at Johns Hopkins Hospital in Baltimore, Maryland before taking on a position as assistant chief of surgery service at Johns Hopkins Hospital from 2001 to 2002. Prior to this, she completed her doctoral studies and medical training as part of the Medical Scientist Training Program, at the State University of New

York (SUNY) in Stony Brook, New York, from 1987 to 1995, where she also received numerous honors for academic excellence. Tchou earned her undergraduate science degree in biochemistry from the College of Mount Saint Vincent in Riverdale, New York, in 1987.

 
Faculty Appointments
2014 - present Associate Professor of Clinical Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2009 - present Adjunct Faculty, The Wistar Institute
Philadelphia, Pennsylvania
 
2007 - present Assistant Program Director, Breast Fellowship
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2007 - present Course Director, Breast Surgery Elective
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2003 - 2014 Assistant Professor of Surgery at HUP
University of Pennsylvania
Philadelphia, Pennsylvania
 
2001 - 2002 General Surgery Instructor
Johns Hopkins School of Medicine
Baltimore, Maryland
 
Hospital and Administrative Appointments
2004 - 2009 Staff Surgeon, Veterans Affairs Medical Center
Philadelphia, Pennsylvania
 
2003 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2001 - 2002 Assistant Chief of General Surgery Service
Johns Hopkins Hospital, Baltimore, Maryland
 
Education/Training
1989 - 1993 PhD - State University of New York at Stony Brook School of Medicine
Stony Brook, New York
(Medical Scientist Training Program)
 
1987 - 1995 MD - State University of New York at Stony Brook School of Medicine
Stony Brook, New York
 
1982 - 1987 BS - College of Mount Saint Vincent
Riverdale, New York
(Biochemistry, Summa Cum Laude)
 
Postgraduate Training and Fellowship Appointments
2002 - 2003 Breast Fellowship Northwestern Memorial Hospital
Chicago, Illinois
 
2001 - 2002 Assistant Chief of Service, Fellow in Gastrointestinal Surgery
Johns Hopkins Hospital, Baltimore, Maryland
 
2000 - 2001 Chief Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
2000 - 2000 Senior Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
1999 - 1999 Registrar, John Radcliffe Hospital
Oxford, United Kingdom
 
1998 - 1999 Senior Assistant Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
1997 - 1998 Research Fellow, Department of Medical Oncology
Johns Hopkins Hospital, Baltimore, Maryland
 
1996 - 1997 Junior Assistant Resident, Johns Hopkins Hospital
Baltimore, Maryland
 
1995 - 1996 Intern, Johns Hopkins Hospital
Baltimore, Maryland
 
Memberships/Societies
2011  Fellow, American College of Surgeons
 
2005 Member, Association of Academic Surgery
 
2003 Member, Society of Surgical Oncology
 
2002 Member, Association of Women Surgeons
 
2002 Member, American Society of Clinical Oncology
 
1989 Member, American Associate of Cancer Research 
 
National, Regional and Local Scientific Committees
2015 - 2018 Breast Disease Site Working Group Member, Society of Surgical Oncology
 
2015 Mentor, Women is Surgery Committee, American college of surgeons
 
2015 One of 40 invited attendees to participate in Artemis Project
National Breast Cancer Coalition – The Breast Cancer Deadline 2020
 
2013 - 2015  Program Committee Member, Association of Academic Surgery
 
2013  Scientist Reviewer, DOD, CDRMP, Breast Cancer Research Program
 
2011 – 2016  Co-director, Developmental Core Program
Penn Transdisciplinary Research on Energetics and Cancer Research Program
 
2010 -  present  Affiliate member, Cancer Center at the Wistar Institute
 
2010 -  present  ECOG Breast Committee's Local-Regional Working Group
 
2009 – present  Member, Tumor Microenivronment and Metastasis Program
The Wistar institute, Philadelphia, Pennsylvania
 
2003 – present Member, Abramson Cancer Center
Perelman School of Medicine at the University of Pennsylvania
 
Research

I have ongoing pre-clinical translational projects and clinical projects centered on breast cancer biology.

The focus of my pre-clinical studies is aimed at fine tuning the efficacy of T-cell based (chimeric antigen receptor or CAR T cell) immunotherapy in the treatment of triple negative breast cancer. As surgeons, we are uniquely positioned to collect fresh tumor samples and implanting them into NOD/SCID/IL-2 gamma chain-deficient (NSG) mice to create a tumor bank in mice. We have already developed several patient-derived xenografts (PDX) in these immunocompromised NSG mice so that we can define intrinsic tumor characteristics that may predict sensitivity or resistance to help select the most effective combination immunotherapy using our PDX NSG mouse tumor model as a platform to tailor treatment strategies.

The second focus of my pre-clinical studies is aimed at defining the effects of combination therapy (chemotherapy or immune checkpoints inhibitors) with CAR T cell based therapy on the tumor cells and the tumor microenvironment and to define the effects of combination immunotherapy on pre-existing endogenous anti-tumor immunity. We have already optimized all tools and assays using an immunocompetent B6 mouse tumor model in the lab.

In terms of clinical studies, I am currently the PI of a clinical trial to evaluate the safety and feasibility of adoptive transfer of autologous chimeric antigen receptor (CAR) T cells to treat patients with metastatic breast cancer via intratumoral injection of CAR T cells genetically modified to target c-met, a hepatocyte growth factor receptor, which is often overexpressed in TNBC and other breast cancer subtypes. This work is performed in partnership with Dr. Carl June. We are currently in the process of developing a new immunotherapy target for triple negative breast cancer (TNBC) by targeting mesothelin, a tumor antigen that is expressed in over 50% of all TNBC.

I am also the PI of a clinical project to collect all breast cancer patient clinical data treated at Penn between 1995 and 2013 to evaluate the effects off metformin use on clinical outcomes of these patients. My research group has collected clinical data on over 1,000 breast cancer patients and will be moving our data into REDCAP database in the next few months. This database is richly annotated with detailed clinical and demographic information for many more outcome studies for residents interested in studies analyzing patient data from a single institution.

 
Publications
Research Publications, peer reviewed
  1. Tchou J, Kasai H, Shibutani S, Chung MH, Laval J, Grollman AP, Nishimura S.  8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.  Proceedings of the National Academy of Sciences of the United States of America 88(11):4690-4694, June 1, 1991.
  2. Tchou J, Michaels ML, Miller JH, Grollman AP.  Function of the zinc finger in Escherichia coli Fpg protein.  Journal of Biological Chemistry 268(35):26738-26744, Dec. 15, 1993.
  3. Tchou J, Bodepudi V, Shibutani S, Antoshechkin I, Miller J, Grollman AP, Johnson F.  Substrate specificity of Fpg protein: Recognition and cleavage of oxidatively damaged DNA. Journal of Biological Chemistry 269(21):15318-15324, May 27, 1994.
  4. Tchou J, Grollman AP.  The catalytic mechanism of Fpg protein: Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site.  Journal of Biological Chemistry 270(19):11671-11677, May 12, 1995.
  5. Tchou JC, Lin X, Freije D, Isaacs WB, Brooks JD, Rashid A, De Marzo AM, Kanai Y, Hirohashi S, Nelson WGGSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. International Journal of Oncology 16(4):663-676, Apr. 2000.
  6. Yam M, Tchou J, English R, Highnam R, Highnam R, Roskell D, Greenall M, Brady M.  A mammographic dilemma: Calcification or haemosiderin as a cause of opacities? Validation of a new digital diagnostic tool.  British Journal of Radiology 74(887):1048-1051, Nov. 2001.
  7. Tchou J, Hou N, Rademaker A, Jordan VC, Morrow M.  Acceptance of tamoxifen chemo-prevention by physicians and women at risk.  Cancer 100(9):1800-1806, May 1, 2004.
  8. Durduran T, Choe R, Yu G, Zhou C, Tchou JC, Czerniecki BJ, Yodh AG. Diffuse optical measurement of blood flow in breast tumors. Optics Letter 30, 2915-2917, 2005.
  9. Vapiwala N, Starzyk J, Harris EE, Tchou JC, Boraas MC, Czerniecki BJ, Rosato EF, Orel SG, Solin LJ: Biopsy findings after breast conservation therapy for early-stage invasive breast cancer. International Journal of Radiation Oncology Biology Physics 2007, 69(2): 490-497.
  10. Tchou J, Ward MR, Volpe P, Palma MD, Medina CA, Sargen M, Sonnad SS, Godwin AK, DalyM, Winchester DJ et al: Large genomic rearrangement in BRCA 1 and BRCA 2 and clinical characteristics of men with breast cancer in the United States.  Clin Breast Cancer. 2007 Jun;7(8):627-33.
  11. Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A: Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters : a potentially useful method for disease characterization.  Cancer 2008 Mar 1;112(5):995-1000.
  12. Weinstein SP, Orel SG, Pinnamaneni N, Tchou J, Czerniecki B, Boraas M, Rosato E, Solin LJ: Mammographic appearance of recurrent breast cancer after breast conservation therapy.  Acad Radiol 2008, 15(2):240-244.
  13. Tchou J, Greshock J, Bergey MR, Sonnad SS, Sargen M, Weinstein S, Czerniecki BJ, Boraas M, Fraker DL, Rosato E et al: Method of primary tumor detection as a risk factor for local and distant recurrence after breast-conservation treatment for early-stage breast cancer.  Clinical Breast Cancer 2008, 8(2):143-148.
  14. Choe R, Konecky SD, Corlu A, Lee K, Durduran T, Busch DR, Pathak S, Czerniecki BJ, Tchou J, Fraker DL, Demichele A, Chance B, Arridge SR, Schweiger M, Culver JP, Schnall MD, Putt ME, Rosen MA, Yodh AG. Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography. J Biomed Opt. 2009 Mar-Apr;14(2):024020.
  15. Tchou J, Sonnad S, Bergey MR, Basu S, Tomaszewski J, Alavi A, Schnall M: Degree of tumor FDG uptake correlates with proliferation index in triple negative breast cancer.Mol Imaging Biol. 2010 Dec;12(6):657-62.
  16. Busch DR, Guo W, Choe R, Durduran T, Feldman MD, Mies C, Rosen MA, Schnall MD, Czerniecki BJ, Tchou J, DeMichele A, Putt ME, Yodh AG:  Computer aided automatic detection of malignant lesions in diffuse optical mammography.  Med Phys. 2010 Apr;37(4):1840-9.
  17. Mislowsky A, Domchek S, Stroede C, Bergey M, Sonnad S, Wu L, Tchou J:  Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation screening  - A retrospective cohort analysis of 158 mutation carriers treated at a single institution.  Ann Surg Oncol. 2011 Mar;18(3):745-51.
  18. Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vonderheide RH, Albelda SM, June CH et al: Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat 2012 Jun; 133(2): 799-804.
  19. Nelson JA, Tchou J, Domchek S, Sonnad SS, Serletti JM, Wu LC: Breast reconstruction in bilateral prophylactic mastectomy patients: Factors that influence decision making. J Plast Reconstr Aesthet Surg 2012.
  20. Tchou J, Kossenkov AV, Chang L, Satija C, Herlyn M, Showe LC, Pure E: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. BMC Med Genomics 2012, 5(1):39.
  21. Busch DR, Choe R, Rosen MA, Guo W, Durduran T, Feldman MD, Mies C, Czerniecki BJ, Tchou J, Demichele A, Schnall MD, Yodh AG. Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy. Biomed Opt Express 2013, 4(1): 105-21.
  22. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S et al: The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design. Cancer Causes Control 2013, 24(4):695-704.
  23. Xu HN, Tchou J, Li LZ. Redox imaging of human breast cancer core biopsies: a preliminary investigation. Acad Radiol 2013; 20, 764-768.
  24. Xu HN, Zheng G, Tchou J, Nioka S, Li LZ. Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging. Springerplus 2013; 2, 73.
  25. Zhang Z, Pal S, Bi Y, Tchou J, Davuluri RV. Isoform level expression profiles provide better cancer signatures than gene level expression profiles. Genome Med 2013; 5, 33.
  26. Fracol M, Xu S, Mick R, Fitzpatrick E, Nisenbaum H, Roses R, Fisher C, Tchou J, Fox K, Zhang P, Czerniecki BJ. Response to HER-2 Pulsed DC1 Vaccines is Predicted by Both HER-2 and Estrogen Receptor Expression in DCIS. Ann Surg Oncol 2013.
  27. Gumireddy K, Li A, Yan J, Setoyama T, Johannes GJ, Orom UA, Tchou J, Liu Q, Zhang L, Speicher DW, Calin GA, Huang Q. Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J 2013.
  28. Brown JC, Cheville AL, Tchou JC, Harris SR, Schmitz KH. Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema. Support Care Cancer 2013.
  29. Tchou J, Zhang PJ, Bi Y, Satija C, Marjumdar R, Stephen TL, Lo A, Chen H, Mies C, June CH, Conejo-Garcia J, Pure E. Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Hum Pathol 2013; 44, 2549-2557.
  30. Brown JC, Cheville AL, Tchou JC, Harris SR, Schmitz KH. Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema. Support Care Cancer. 2014; 22(1): 135-43.
  31. Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, et al. Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer. J Vis Exp. 2014; (85).
  32. Wes AM, Fischer JP, Tuggle CT, Nelson JA, Tchou JC, Serletti JM, et al. Abstract 36: Risk Assessment of Immediate Breast Reconstruction Relative to Mastectomy Alone: Analysis of 30-day Complications Using the ACS-NSQIP. Plast Reconstr Surg. 2014; 133(4 Suppl): 1000.
  33. Choe R, Putt ME, Carlile PM, Durduran T, Giammarco JM, Busch DR, Jung KW, Czerniecki BJ, Tchou J, Feldman MD et al: Optically measured microvascular blood flow contrast of malignant breast tumors. PLoS One 2014, 9(6):e99683.
  34. Brown JC, Kumar A, Cheville AL, Tchou JC, Troxel AB, Harris SR, Schmitz KH: Association Between Lymphedema Self-Care Adherence and Lymphedema Outcomes Among Women with Breast Cancer-Related Lymphedema. Am J Phys Med Rehabil 2014.
  35. Fischer JP, Wes AM, Tuggle CT, Nelson JA, Tchou JC, Serletti JM, Kovach SJ, Wu LC: Mastectomy with or without immediate implant reconstruction has similar 30-day perioperative outcomes. J Plast Reconstr Aesthet Surg 2014.
  36. Li YR, Xian RR, Ziober A, Conejo-Garcia J, Perales-Puchalt A, June CH, Zhang PJ, Tchou J: Mesothelin expression is associated with poor outcomes in breast cancer. Breast Cancer Res Treat 2014.
  37. Wes AM, Fischer JP, Tuggle CT, Nelson JA, Tchou JC, Serletti JM, Kovach SJ, Wu LC: Abstract 36: Risk Assessment of Immediate Breast Reconstruction Relative to Mastectomy Alone: Analysis of 30-day Complications Using the ACS-NSQIP. Plast Reconstr Surg 2014, 133(4 Suppl):1000.
  38. Offodile AC, 2nd, Chatterjee A, Vallejo S, Fisher CS, Tchou JC, Guo L: A Cost-Utility Analysis of the Use of Preoperative Computed Tomographic-Angiography in Abdomen-Based Perforator Flap Breast Reconstruction. Plast Reconstr Surg 2014.
  39. Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J et al: Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer. J Vis Exp 2014(85).
  40. Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J et al: Transforming growth factor beta-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity 2014, 41(3):427-439.
  41. Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Tesone AJ, Perales-Puchalt A, Brencicova E, Escovar-Fadul X, Nguyen JM, Cadungog MG et al: Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation. Cancer Cell 2015, 27(1):27-40.
  42. Chung SH, Feldman MD, Martinez D, Kim H, Putt ME, Busch DR, et al. Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures. Breast Cancer Res. 2015 May 27;17(1):72.
  43. Tchou J, Lam L, Li Y, Edwards C, Ky B, Zhang H. Monitoring serum HER2 levels in breast cancer patients. Springerplus. 2015 Jan;4(1):237.
  44. Chatterjee A, Pyfer B, Czerniecki B, Rosenkranz K, Tchou J, Fisher C. Early postoperative outcomes in lumpectomy versus simple mastectomy. J Surg Res. 2015 Sep;198(1):143–8.
  45. Basta MN, Fischer JP, Kanchwala SK, Silvestre J, Wu LC, Serletti JM, et al. A Propensity-Matched Analysis of the Influence of Breast Reconstruction on Subsequent Development of Lymphedema. Plast Reconstr Surg. 2015 Aug;136(2):134e – 43e.
  46. Pyfer B, Chatterjee A, Chen L, Nigriny J, Czerniecki B, Tchou J, et al. Early Postoperative Outcomes in Breast Conservation Surgery Versus Simple Mastectomy with Implant Reconstruction: A NSQIP Analysis of 11,645 Patients. Ann Surg Oncol. 2015 Jul 29.
  47. Chatterjee A, Pyfer B, Chen L, Czerniecki B, Tchou J, Fisher C. Resident and Fellow Participation in Breast Surgery: An American College of Surgeons NSQIP Clinical Outcomes Analysis. J Am Coll Surg. 2015 Aug 20.
Reviews in Peer-Reviewed Research Publications
  1. Michaels ML, Tchou J, Grollman AP, Miller JH. A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry. 1992 Nov 17;31(45):10964-8.
  2. Tchou J, Grollman AP.  Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine.  Mutation Research 299(3-4):277-287, May 1993.
  3. Grollman AP, Johnson F, Tchou J, Eisenberg M.  Recognition and repair of 8-oxoguanine and formamidopyrimidine lesions in DNA.  Annals of the New York Academy of Sciences 726:208-214, July 29, 1994.
  4. Tchou J, Morrow M.  Available models for breast cancer risk assessment:  How accu-rate are they?  Journal of American College of Surgeons 197(6):1029-1035, Dec. 2003.
  5. Cheville AL, Tchou J Barriers to rehabilitation following surgery for primary breast cancer.. J Surg Oncol. 2007 Apr 1;95(5):409-18.
  6. Nelson JA, Tchou J, Domchek, S, Low DW, Serletti JM, Wu LC: Breast reconstruction – A historical perspective on available techniques for patients electing bilateral mastectomy. Current Cancer Therapy Reviews 2011 Nov: 7(4): 272-281.
  7. Nelson JA, Nelson P, Tchou J, Serletti JM, Wu LC: The ethnic divide in breast reconstruction: A review of the current literature and directions for future research. Cancer Treat Rev 2012, 38(5):362-367.
  8. Lam L, McAndrew N, Yee M, Fu T, Tchou JC, Zhang H: Challenges in the clinical utility of the serum test for HER2 ECD. Biochim Biophys Acta 2012. Aug; 1862(1): 199-208.
  9. Fisher CS, Freedman GM, Tchou J: Can we identify a subset of patients with DCIS that can be treated by wide excision alone? Current Cancer Therapy Reviews 2012, 8(3):177-181.
  10. Tchou J, Conejo-Garcia J: Targeting the tumor stroma as a novel treatment strategy for breast cancer: shifting from the neoplastic cell-centric to a stroma-centric paradigm. Adv Pharmacol 2012, 65:45-61.
  11. Xu HN, Tchou J, Chance B, Li LZ: Imaging the redox states of human breast cancer core biopsies. Adv Exp Med Biol. 2013; 765:343-9.
  12. Cintolo JA, Tchou J, Pryma DA: Diagnostic and prognostic application of positron emission tomography in breast imaging: emerging uses and the role of PET in monitoring treatment response. Breast Cancer Res Treat 2013.
  13. Cubillos-Ruiz J, Rutkowski MR, Tchou J, Conejo-Garcia J: Reprogramming immune responses via microRNA modulation. microRNA Diagnostics and Therapeutics 2013, 1-11.
  14. Tchou J, Conejo-Garcia J. Fibroblast activation protein, a potential diagnostic and therapeutic target for cancer-reply. Hum Pathol. 2014.
Grant review by invitation, past 5 years
  1. Developmental Pilot Project Grant review, TREC, 2012
  2. Scientist reviewer, 2012 Breast Cancer Research Program for the United States Department of Defense Congressionally Directed Medical Research Programs.
  3. Invited reviewer for 2015 American Cancer Society Institutional research grant at the Wistar Institute
  4. Invited reviewer for 2015 Breast Cancer Alliance Exceptional Project Grants
Abstracts
  1. Tchou J,  Hou N, Rademaker A, Jordan VC, Morrow M.  Acceptance of Tamoxifen (Tam) as Chemoprevention.  Program/Proceedings of the American Society of Clinical Oncology, 2003.
  2. Morrow M, Tchou J, Nakhlis F, Hou N, Rademaker A, Khan S.  Acceptance of Tamoxifen (Tam) Chemoprevention varies with the cause of breast cancer risk.  Program/Proceedings of the American Society of Clinical Oncology, 2003.
  3. Tchou J, Greshock J, Rebbeck T, Weber L and Solin L.  Predicting distant metastasis after local recurrence (failure) in women treated by breast conserving treatment. Abstract no. 1060, 28th annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment 94(1), 2005.
  4. Tchou, J, Ward, R, Volpe, P, Medina, A, Weber, B, Domchek, S and Nathanson, K.  Frequency of BRCA1 and BRCA2 genomic rearrangements and mutations in men with breast cancer: A clinic-based study in the United States, Society of Surgical Oncology Annual Meeting, March 2006.
  5. Tchou J, Sonnad S, Sargen M, Weber B, Nathanson K, Domchek S. Contralateral prophylactic mastectomy in affected carriers of deleterious BRCA1 or BRCA2 mutations:  Does timing of genetic testing matter?  Abstract no. 10512, ASCO Annual Meeting Proceedings, 2006.
  6. Tchou J, Wang LP, Sargen M, Sonnad S, Tomaszewski J, and Schnall M. Do triple-negative breast cancers have a distinct imaging phenotype? Abstract no. 551108, 29th Annual San Antonio Breast Cancer Symposium, 2006.
  7. Tchou J, Sargen M, Sonnad S, Weber BL, Nathanson K, Domchek S. Characteristics of BRCA1 and BRCA2 mutation carriers who chose prophylactic mastectomy. Accepted as Poster Presentation, Society of Surgical Oncology Annual Meeting, March 2007.
  8. Mislowsky A, Domchek S, Stroede C, Bergey MR, Sonnad S, Wu L, and Tchou J. Surgical trends in BRCA1/2 mutation carriers with breast cancer – a single institution experience. Poster presentation, American Society of Breast Surgeons Annual Meeting, Las Vegas, NV, April 28, 2010.
  9. Nelson JA, Domchek SM, Tchou J, Serletti JM, Wu LC. Bilateral prophylactic mastectomy and breast reconstruction: What influences the decision? Presented at the 54th Annual Meeting of the Ohio Valley Society of Plastic Surgeons conjoined with the Ivy Society of Plastic Surgery. White Sulfur Springs, West Virginia, June 2-4 2011.
  10. Karemore G, Hue N, Keller B, Tchou J, Conant E, Kontos D. Computer-aided Parenchymal Texture Analysis in Digital Mammograms: The Potential for Estrogen-Receptor Specific Breast Cancer Risk Estimation. Oral presentation, RSNA 97th Scientific Assembly and Annual Meeting, November 27 – December 2, 2011, McCormick Place, Chicago, Illinois.
  11. Tchou J, Satija C, Zhang P, Bi YT, Chen HY, Majumdar R, Chang L, Davuluri R, Showe L, Mies C, Herlyn M, and Puré E. Significance of FAP, SMA and CD31 expression in the stroma of breast. Poster presentation P1-03-09, CTRC-AACR San Antonio Breast Cancer Symposium, December 7, 2011, San Antonio, Texas.
  12. Tchou J, Wang, L-C, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vonderheide RH, Albelda SM, June CH, Zhang PJ: Mesothelin, a novel immunotherapy target for triple negative breast cancer. Poster and oral presentation X-9, 15th Annual Translational Research Cancer Centers Consortium, Seven Springs, PA.
  13. Tchou J, Kossenkov AV, Chang L, Satija C, Herlyn M, Showe LC, Puré E. Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. Poster Presentation, American Society of Breast Surgeons Annual Meeting, May 2-4, 2012, Phoenix, Arizona.
  14. Xian R, Tchou J, Ziober A, Vonderheide R, June C, Zhang PJ. African American women with breast cancer show higher expression of the targetable cell surface protein Mesothelin. Poster presentation, 102nd United States and Canadian Academy of Pathology Annual Meeting, March 2-8, 2013, Baltimore, MD.
  15. Edwards C, Ky B, Tchou J, Zhang H. Monitoring soluble Her2 extracellular domain in the serum of breast cancer patients using a refined ELISA Assay. Poster Presentation, Society of Surgical Oncology Annual Meeting, March 2013, Washington DC.
  16. Edwards C, Freedman G, Czernieck B, Tchou J, Fisher CS. Evaluation of margin index for prediction of residual disease after breast-conserving surgery: Can it be a useful tool for the breast surgeon? Poster Presentation, American Society of Breast Surgeons Annual Meeting, May 2013, Chicago.
  17. Okusanya OT, Judy B, Venegas O, Quatromoni J, Singhal S, Tchou J. A Novel Technique for Near Infrared (NIR) Intraoperative Imaging of Breast Cancer and Sentinel Lymph Nodes (SLNs). Oral Presentation. American College of Surgeons’ 99th clinical Congress, October 7 2013, Washington DC.
  18. Li Y and Tchou J. Association between metformin use and improved survival in breast cancer patients: a population-based study.  Poster Presentation, San Antonio Breast Cancer Conference, December 2013, San Antonio.
  19. Li, YR, Xian RR, Ziober A, Conejo-Garcia J, Perales-Puchalt, June CH, Tchou J. Mesothelin expression is associated with poor outcomes in breast cancer. Poster Presentation, ASCO Annual Meeting, May 31, 2014, Chicago.
  20. Xe HN, Tchou J, Feng M, Li LZ. Differentiating cancerous from normal breast tissue by redox imaging. Biophotonics imaging conference, Feb, 2015, San Francisco.
  21. Xu, HN, Tchou J, Feng M, Zhao HQ, Sun N, Zhang S, Moon L, Li LZ. Redox biomarkers for breast cancer diagnosis and prognosis: two pilot studies of clinical specimens. ISOTT conference, Wuhan, PRC, July 2015
Editorials, Reviews, Chapters
  1. Tchou J, Morrow M.  Overview of clinical risk assessment.  In Morrow M, Jordan VC (eds): Managing Breast Cancer Risk.  Hamilton, Ontario: BC Decker, 2003, pp. 3-25.
  2. Kruper L, Tchou J.  The breast. In Atluri P, Karakousis GC, Porrett PM, Kaiser LR (eds): The Surgical Review. 2nd Edition. Philadelphia, PA: Lippincott Williams & Wilkins, 2006, pp. 502-517.
  3. Solin L, Harris E, Weinstein S, DeMichele A, and Tchou J.  Local-Regional Recurrence after Breast-Conservation Treatment or Mastectomy.  In Harris J, Morrow M, Lippman M, Osborne C (eds): Diseases of the Breast. Fourth Edition.  Philadelphia, Pa: Lippincott Williams & Wilkins, a Wolters Kluwer business, 2010, pp. 840-855.
  4. Tchou J.  Breast Cancer Diagnostic Algorithms for Primary Care Providers.  In Counter Details, Pennsylvania Medical Society, 2010.
  5. Karemore G, Keller B, Oh H, Tchou J, Nielsen M, Conant E, Kontos D. Mammographic parenchymal texture analysis for estrogen-receptor subtype specific breast cancer risk estimation. In Maidment ADA, Bakic PR, Gavenonis S (eds): Proceedings of International Workshop on Breast Imaging (IWDM), Lecture Notes in Computer Science (LNCS). Springer-Verlag Berlin Heidelberg 7361: 596-603, June 2012.
Alternative Media
  1. 2011 - CBS3 TV Interview regarding Z11 trial
  2. 2011 - WHYY radio interview regarding Z11 trial
  3. 2012 - Philadelphia Inquirer featured in an article in 10/18/2012 noting that Julia Tchou as one of the two Penn breast surgeons to perform the most number of mastectomies
Patents
  1. Project title: Genetic Diagnosis of Hepatocellular Carcinoma (Liver Cancer) (JHU Ref. DM-3602); Inventors: William G. Nelson, Xiaohui Lin, Julia C. Tchou, Jila Bakker; U.S. Patent pending, 2003.
 
Awards, Honors and Membership in Honorary Societies
2010 - 2015 Consecutively named “Top Doc” in Philadelphia Magazine
 
2014 Mentee, Susan Komen Leadership grant
 
2014 Conquer Cancer Foundation of ASCO Merit Award for poster presentation at ASCO “Mesothelin expression is associated with poor outcomes in breast cancer”
 
2013 Breast Cancer Alliance Exceptional Project Award
 
2004 - 2006 American College of Surgeons Faculty Research Fellowship
 
1998 George D. Zuidema Surgical Residents Research Award
 
1997 Arnold M. Seligman Award for the most outstanding surgical resident of the year
 
1995  KiJeon Li Award for determination in pursuit of a medical education
 
1994 Alpha Omega Alpha
 
1987 Student Award for General Excellence
 
1987 Student Award in Biochemistry
 
1987 Sigma Xi Research Award for Undergraduate Student of the Year
 
1987 Student Award from the American Institute of Chemists
 
1982-1987 Presidential Scholarship, College of Mount Saint Vincent, Riverdale, New York

Dr. Julia Tchou

 
footer Terms of Use Legal Disclaimer Site Map Contact Us Financial Assistance About Penn Medicine Privacy Statement
penn medicine