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Chase R. Brown, M.D.
Cardiac Surgery Direct Resident

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

chase.brown@uphs.upenn.edu

 

Dr. Brown is a PGY1 in the Cardiac Surgery Direct Program. His interests include aortic surgery. He plans to pursue a career in academic cardiac surgery.

 

 
Appointments
2014 - present Assistant Instructor in Surgery
 
 
 
 
 
            
 
 
 
 
 
Education/Training
2014 - present Cardiac Direct Surgery Program
Hospital of the University of Pennsylvania
 
2009 - 2014 MD - Cleveland Clinic Lerner College of Medicine
 
2006 - 2008 BA - Wheaton College
 
 
 
 
 
 
Memberships/Societies
  • Pre-candidate Member, Society of Thoracic Surgeons
  • Student Member, Society of Vascular Surgery
  • Junior Member, International Society of Heart and Lung Transplantation
 
 
 
 
 
 
 
 
Research
 
The Cleveland Clinic - Cleveland, OH
7/2011 - 6/2012 Co-Investigator: Thesis Project
Principle Investigator Roy Greenberg, MD, Department of Vascular Surgery. “Identification of Genetic Variants that Predispose Patients to Distal Aortic Aneurysms.”  Performed a prospective study to identify genetic mutations in candidate genes of patients with aortic aneurysms and a positive family history. Additionally, investigated how a positive family history of aortic disease can predict a patient's aneurysmal disease pattern and progression.
 
7/2010 - 6/2012 Research Assistant
Principle Investigator David P. Mason, MD, Department of Cardiothoracic Surgery.
“Ex-Vivo Reconditioning of the Human Lung: Increasing Donor Organ Utilization.” 
Investigated the use of Ex-Vivo Lung Perfusion to evaluate and recondition marginal donor lungs.  Received NHLBI T32 trainee grant for this study.
 
7/2009 - 12/2009 Research Assistant
Principle Investigator Marc Penn, MD, PhD, Department of Cell Biology.
“Effects of Older Marrow on Cardiac Compensation in Pressure Overload”
Investigated the effects of stem cell mediated repair of the heart in the setting of high afterload heart failure in a mouse mode
 
Brigham and Women’s Hospital - Boston, MA
5/2008 - 8/2008 Research Assistant
Principal Investigator David Sugarbaker, Department of Thoracic Surgery.               
“Effects of Cisplation and Rapamycin on the Cell Cycle of Mesothelioma Tumor Cells”
Investigated the effects of cisplatin and rapamycin on cell cycle arrest in mesothelioma tumor cells.
 
Publications
 
Peer-Reviewed Articles
  1. Brown CR, Mason D, Budev M. Early Graft Dysfunction after Lung Transplantation. American Journal of Transplantation. 2014 (Accepted)
  2. Shafii A, Mason D, Brown CR, Murthy S, Pettersson G. How High is Too High? Lung Transplantation in the Era of the Lung Allocation Score. Thoracic and Cardiovascular Surgeon, 2014. (Accepted)
  3. Brown CR, Greenberg R, Wong S, Eagleton M, Mastracci T, Rigelsky C, Hernandez A, Moran R.  Family History of Aortic Disease Predicts Patterns and Progression and is a Significant Influence on Patients and Their Relatives. Journal of Vascular Surgery, 2013; 58(3):573-81. PMID: 23809203
  4. Wong S, Greenberg R, Eagleton M, Mastracci T, Brown CR, Hernandez A.  Endovascular repair of Aortoiliac Aneurysmal Disease with the Helical Iliac Bifurcation Device and the Bifurcated-Bifurcated Iliac Bifurcation Device.  Journal of Vascular Surgery, 2013; 58(4): 861-69. PMID: 23790453
  5. Brown CR, Shafii A, Farver C, Murthy S, Pettersson G, Mason D.  Pathologic Correlates of Heparin-Free Donation after Cardiac Death in Lung Transplantation.  Journal of Thoracic and Cardiovascular Surgery, 2013; 13, 112-118. PMID: 23419654
  6. Keshava H, Farver C, Brown CR, Shafii A, Murthy C, Yun J, Vakil N, Pettersson G, Mason D. Timing of Heparin and Thrombi Formation in Donor Lungs after Cardiac Death. Thoracic and Cardiovascular Surgeon, 2013; 61(3), 246-250. PMID: 23085328
  7. Brown CR, Mason D, Pettersson G, Murthy S. Outcomes after Single Lung Transplantation in Older Patients with Secondary Pulmonary Arterial Hypertension. Journal of Heart and Lung Transplantation, 2013; 32(1), 134-136. PMID: 23085328
  8. Shafii A, Mason D, Brown CR, Vakil N, Pettersson G, Murthy S. Growing Experience with Extracorporeal Membrane as a Bridge to Lung Transplantation. American Society of Artificial Internal Organs Journal, 2012; 58(5), 526-529. PMID: 22929896
  9. Shafii A, Brown CR, Murthy S, Mason DP. High Incidence of Upper-Extremity Deep Vein Thrombosis with Dual-Lumen Venovenous Extracorporeal Membrane Oxygenation. Journal of Thoracic Cardiovascular Surgery, 2012; 144(4), 988-989. PMID: 22789300
  10. Mason D, Brown CR, Murthy S, Vakil N, Lyon C, Budev M, Pettersson G. Growing Single-Center Experience With Lung Transplantation Using Donation After Cardiac Death. Annals Thoracic Surgery, 2012; 94(2), 406-412. PMID: 22608715
  11. Brown CR, Brozzi N, Vakil N, Shafii A, Murthy S, Pettersson G, Mason D. Evaluation of Donor Lungs with Pulmonary Embolism Using Ex-Vivo Lung Perfusion. American Society of Artificial Internal Organs, 2012; 58(4), 432-434. PMID: 22588145
  12. Brown CR, Kitagawa A, Greenberg, R. Endovascular Strategies for the Management of Aortic Connective Tissue Disorders. Journal of Cardiovascular Surgery, 2012; 53(Suppl.1 to No. 1), 35-42. PMID: 22433722
  13. Keshava H, Mason D, Murthy S, Brown CR, Pettersson G. Pediatric Donor Lungs for Adult Transplant Recipients: Feasibility and Outcomes. Thoracic and Cardiovascular Surgeon, 2012; 60(4), 275-279. PMID: 22228089
  14. Quintini C, D’Amico G, Brown CR, Aucejo F, Hashimoto K, Kelly D, Eghtesad B, Sands M, Fung J, Miller C. Splenic Artery Embolization for the Treatment of Refractory Ascites after Liver Transplantation. Liver Transplantation, 2011; 17(6), 668-73. PMID: 21618687
  15. Sopko N, Turturice B, Becker M, Brown CR, Dong F, Popovic Z, Penn M. Bone marrow support of the heart in pressure overload is lost with aging. PLoS One, 2010; 5(12), 1-12. PMID: 21203577
Book Chapters
  1. Brown CR and Mason D. "Lung Transplantation". Elsevier. First Consult. Available at: https://www.clinicalkey.com/#!/ContentPlayerCtrl/doPlayContent/21-s2.0-2001319/{"scope":"all","query":"lung transplantation"}. Posted April 22, 2013.
  2. Brown CR, Greenberg R. "Endovascular Management of Connective Tissue Disorders". Jeffrey Geschwind and Michael Dake (editors), Abrams Angiography: Interventional Radiology, 3rd edition, Lippincott Williams & Wilkins. 2013.
Oral Presentations
  1. Brown CR, Greenberg R, Wong S, Eagleton M, Mastracci T, Moran R. Impact of Family History on Aortic Disease Patterns. 7th Annual Introduction to Academic Vascular Surgery, USF Health Center, Tampa, FL, 04/2013
  2. Brown CR, Greenberg R, Wong S, Eagleton M, Mastracci T, Moran R. Impact of Family History on Aortic Disease Patterns. Society of Vascular Surgery, 2012 Vascular Annual Meeting, Washington, DC, 06/2012
  3. Brown CR, Mason D, Shafii A, Murthy S, Pettersson G. How High is Too High? Lung Transplantation in the Era of the Lung Allocation Score. Thoracic and Cardiovascular Surgery Research Day, Cleveland Clinic, Cleveland, OH, 06/2012
  4. Brown CR, Brozzi N, Vakil N, Shafii A, Murthy S, Pettersson G, Mason D. Evaluation and Treatment of Donor Lungs with Pulmonary Embolism Using Ex-Vivo Lung Perfusion. Emerging Issues in Organ Transplantation: A Colloquium, Cleveland Clinic, Cleveland, OH. 10/2011
  5. Brown CR, Quintini C. Diago T, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Intraoperative Flow Measurements Facilitate in the Detection of Celiac Axis Stenosis in Patients Undergoing Liver Transplantation. American Transplant Congress, ATC Meeting 2011, Philadelphia, PA, 05/2011
  6. Brown CR, Mason D, Murthy S, Pettersson G. Lung Transplantation in Patients Older than 65 Years: Early Single Center Experience in the Era of the Lung Allocation Score. American Transplant Congress, ATC Meeting 2011, Philadelphia, PA, 05/2011
Poster Presentations
  1. Brown CR, Shafii A, Murthy S, Pettersson G,  Budev M, Mason D. Losing the War Before the First Battle: Explant Malignancy in Lung Transplantation. International Society for Heart and Lung Transplantation, 33rd Annual Meeting, Montreal, Canada, 04/2013
  2. Brown CR, Shafii A, Farver C, Murthy S, Pettersson G, Mason D. Pathologic Correlates of Heparin Free Donation after Cardiac Death in Lung Transplantation. American Society of Transplant Surgeons, Winter Symposium, Miami, FL, 02/2013
  3. Brown CR, Brozzi N, Vakil N, Shafii A, Murthy S, Pettersson G, Mason D.  Evaluation and Treatment of Donor Lungs with Pulmonary Embolism Using Ex-Vivo Lung Perfusion. American Society of Transplant Surgeons, Winter Symposium, Miami, FL, 01/2012
  4. Brown CR, Mason D, Murthy S, Pettersson G. Single Lung Transplant in the Elderly: Impact of Pulmonary Hypertension. International Society for Heart and Lung Transplantation, 31st Annual Meeting, San Diego, CA, 04/2011
  5. Brown CR, Quintini C, Diago T, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Intraoperative Flow Measurements Facilitate in the Detection of Celiac Axis Stenosis in Patients Undergoing Liver Transplantation.  American Society of Transplant Surgeons, Winter Symposium, Hollywood, FL, 01/2011
  6. Brown CR, Mason D, Murthy S, Pettersson G. Lung Transplantation in Patients Older than 65 Years: Early Single Center Experience in the Era of the Lung Allocation Score.  American Society of Transplant Surgeons, Winter Symposium, Hollywood, FL, 01/2011
Abstracts
  1. Brown CR, Shafii A, Murthy S, Pettersson G,  Budev M, Mason D. Losing the War Before the First Battle: Explant Malignancy in Lung Transplantation. Journal of Heart and Lung Transplantation, 2013; 32(4), S214.
  2. Keshava K, Mason D, Brown CR, Pettersson G, Murthy S. Dual-Lumen Veno-Venous Cannula and ECMO as a Bridge to Lung Transplantation. American Journal of Transplantation, 2013. 13, 95-96.
  3. Brown CR, Brozzi N, Vakil N, Shafii A, Murthy S, Pettersson G, Mason D.  Evaluation and Treatment of Donor Lungs with Pulmonary Embolism Using Ex-Vivo Lung Perfusion. American Journal of Transplantation, 2012; 12, 91.
  4. Mason D, Brown CR, Thuita L, Murthy S, Pettersson G, Blackstone E. Too High for Transplantation? Single-Center Analysis of the Lung Allocation Score. American Journal of Transplantation, 2012; 12, 63.
  5. Brown CR, Mason D, Murthy S, Pettersson G. Single Lung Transplant in the Elderly: Impact of Pulmonary Hypertension. Journal of Heart and Lung Transplantation. 2011; 30(4) S204.
  6. Miller C, D’Amico G, Brown CR, Aucejo F, Hashimoto K, Kelly D, Eghtesad B, Sands M, Fung J, Quintini C.  Splenic Artery Embolization for the Treatment of Refractory Ascites after Liver Transplantation. Liver Transplantation. 2011; 17(6), S114.
  7. Quintini C, Brown CR, D’Amico G, Diago T, Fujiki M, Hodgkinson P, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Splenic Artery Embolization Is a Safe Procedure and Improves Intrahepatic Arterial Perfusion in Liver Transplant Patients.  Liver Transplantation. 2011; 17(6), S180.
  8. Brown CR, Quintini C, D’Amico G, Diago T, Fujiki M, Hodgkinson P, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Strategies to Decrease the Rate of Hepatic Artery Thrombosis in Liver Transplant Recipients: the Importance of Intraoperative Flow Measurements.  Liver Transplantation. 2011; 17(6) S164.
  9. Brown CR, Mason D, Murthy S, Pettersson G. Lung Transplantation in Patients Older than 65 Years: Early Single Center Experience in the Era of the Lung Allocation Score.  American Journal of Transplantation. 2011; 11, 85.
  10. Murthy S, Mason D, Yun J, Brown CR, Pettersson G. Feasibility and Early Outcome of Concomitant LTx-CABG for Patients with Coexisting Disease, American Journal of Transplantation. 2011; 11, 78.
  11. Diago T, Brown CR, D’Amico G, Quintini C, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Reno-Portal By-Pass in Patients with Severe Portal Vein Thrombosis and Large Spleno-Renal Shunts: Should It Represent the Revascularization Technique of Choice? American Journal of Transplantation. 2011; 11, 80.
  12. Quintini C, Brown CR, D’Amico G, Diago T, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C.  Preliminary Experience with Side-to-Side Cavo-cavostomy in Liver Transplantation Using Endovascular Stapler. American Journal of Transplantation. 2011; 11, 333.
  13. Brown CR, Gunasekaran G, Fujiki M, D'Amico G, Quintini C, Hashimoto K, Aucejo F, Kelly D, Eghtesad B, Fung J, Miller C  Intraoperative Flow Measurement Facilitate in the Detection of Celiac Axis Stenosis in Patients Undergoing Orthotopic Liver Transplantation. American Journal of Transplantation. 2011; 11, 80.
 
Awards
2013 2nd Place–Research Manuscript Competition
7th Annual Introduction to Academic Vascular Surgery, USF Health Center
Tampa, Florida
 
2012 Top Ten Research Proposal–Introduction to Research Principles
Vascular Annual Meeting
Washington D.C.
 
2012 Vascular Annual Meeting Student Travel Award, Vascular Annual Meeting
Washington D.C.
 
2011 Poster of Distinction Award–American Society of Transplant Surgeons:
Winter Symposium, Hollywood, Florida
 
2011 National Heart, Lung and Blood Institute T32 Trainee Grant
 
2011 American Association of Thoracic Surgery (AATS) Summer Intern Scholarship
 
2007 Sugarbaker Summer Research Intern at Brigham and Women’s Hospital
 
2006 - 2009 President’s List, Wheaton College

Dr. Chase Brown

 
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