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Scott M. Damrauer, M.D.
Vascular Surgery

 
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  • Memberships
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6157

Contact Information (internal use only)

Scott.Damrauer@uphs.upenn.edu

 

Dr. Scott Damrauer is a Fellow in Vascular Surgery and Endovascular Therapy. Before coming to the Hospital of the University of Pennsylvania, he completed his general surgery training at Massachusetts General Hospital. During his surgical residency he spent three years in the laboratory of Dr. Chistiane Ferran studying the role of inflammation in both occlusive and aneurysmal vascular disease as part of the Beth Israel Deaconess Medical Center’s Vascular Surgery NIH T32 training grant. His current research focuses on leveraging genomic approaches to understand the pathophysiology of vascular disease.

 
Appointments
2012 – present 

Instructor in Surgery, University of Pennsylvania

 
 
 
 
 
 
 
 
 
Education/Training
7/2012 – present  Postgraduate Vascular Surgery Fellow
Hospital of the University of Pennsylvania
 
7/2010 – 6/2012 Resident in Surgery
Massachusetts General Hospital
 
7/2007 – 6/2010 Research Fellow in Surgery, Center for Vascular Biology Research
Beth Israel Deaconess Medical Center
 
6/2004 – 6/2007 Resident in Surgery
Massachusetts General Hospital
 
9/1999 – 6/2004  MD, Harvard Medical School
Boston, Massachusetts
 
9/195 – 6/1999 AB, Biochemistry, Harvard College
Cambridge, Massachusetts
 
Memberships/Societies
  • American College of Surgeons, Resident Member
  • Society for Vascular Surgery, Candidate Member
  • International Society of Endovascular Specialists
  • Delaware Valley Vascular Society, Candidate Member
 
 
 
 
 
 
Research

Dr. Damrauer’s research leverages genomic techniques to characterize the biological pathways and cellular mechanisms that are most relevant for vascular disease. In the context of a patient-oriented research protocol, he is using next-generation DNA sequencing in two important groups: individual patients with severe and/or early-onset vascular disease, and families with highly penetrant vascular disease. This will identify specific mutated genes underlying the patients’ disease and allow their isolation for study in in vitro and in vivo model systems. Understanding the molecular mechanisms that underlie these specific, rare forms of vascular disease will have mechanistic relevance for more common forms of vascular disease, and is a promising strategy to develop innovative, targeted treatments. This work is being done collaboratively with Dr. Dan Rader in the Division of Cardiology and the Penn Cardiovascular Institute.

 
Publications
Research Publications, peer-reviewed
  1. Schecter, L.M., Damrauer, S.M., Lee, C.A.: Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter. Molecular Microbiology 32:629-642, 1999.
  2. Damrauer, S.M., Defina, R., He, H., Haley, KJ., and Perkins, D.L.: Molecular profiles of allograft rejection following inhibition of CD40 ligand costimulation differentiated by cluster analysis. Journal of Leukocyte Biology 71:348-358, 2002.
  3. Hongo, D., Hadidi, S., Damrauer, S., Garrigue, V., Kraft, D., Sachs, D.H., Nikolic, B., Sykes, M.: Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. Journal of Infectious Diseases 196:900-910, 2007.
  4. Damrauer, S.M., Bordeianou, L., Berger., D.: Contained anastomotic leaks: are we too slow to act? Archives of Surgery 144:333-338, 2009.
  5. Ramsey, H.E., da Silva, C.G,, Longo, C.R., Csizmadia, E., Studer, P., Patel, V.I., Damrauer, S.M., Siracuse, J.J., Daniel, S., Ferran, C.: A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. Liver Transplantation 15:1613-1621, 2009.
  6. Kopcow., H., Eriksson, M., Mselle, T.F., Damrauer, S.M., Wira, C.R., Sentman, C.L., Strominger, J.L.: Human Decidual NK Cells from Gravid Uteri and NK Cells from Cycling Endometrium are Distinct NK Cell Subsets. Placenta 211:404-448, 2010.
  7. Damrauer, S.M.*, Fisher, M.D.*, Wada, W., Siracuse, J.J., da Silva, C.G., Moon, K., Csizmadia, E., Maccariello, E.R., Patel, V.I., Aird, W.C., Daniel, S., Ferran, C.: A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis 211:404-8, 2010.
  8. Feng, J,*, Damrauer, S.M.*, Lee., M., Selke, F.W., Ferran, C., Abid, M.R.: Endothelium-dependent Coronary Vasodilatation Requires NADPH Oxidase-derived ROS. Arteriosclerosis, Thrombosis, and Vascular Biology 30:1703-1710, 2010.
  9. Shrikhande, G.V., Scali, S.T., da Silva, C.G., Damrauer, S.M., Cszimadia, E., Putheti, P., Matthey, M., Arjoon, R., Patel, R., Siracuse, J.J., Maccariello, E.R., Anderson, N.D., Monahan, T., Peterson, C., Essayagh, S., Studer, P., Guedes, .R.P., Kocher, O., Usheva, A., Veves, A., Kaczmarek, E., Ferran, C.: O-Glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice. PLoS ONE 5:e14240, 2010.
  10. Damrauer, S.M.*, Studer, P.*, da Silva, G.C., Longo, C., Ramsey, H.E., Csizmadia, E., Shrikhande, G., Scali, S.T., Liberman, T.A., Bhasin, M.K., Ferran, C.: A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE 6:e17715, 2011.
  11. da Silva, C.G., Maccariello, E.R., Wilson, S.W.,  Putheti, P., Daniel, S., Damrauer, S.M., Peterson, C., Siracuse, J.J., Kaczmarek, E., Ferran, C.: Hepatocyte Growth Factor preferentially activates the anti-inflammatory arm of NF-κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation. Journal of Cellular Physiology 27:1382-1390, 2012.
  12. Siracuse, J.J., Fisher, M.D., da Silva, C.G., Peterson, C.R., Csizmadia, E., Moll, H.P., Damrauer, S.M., Studer, P., Choi, L.Y., Essayagh, S., Kaczmarek, E., Maccariello, E.R., Lee, A., Daniel, S., Ferran, C.: A20-mediated modulation of inflammatory and immune responses in aortic allografts and development of transplant arteriosclerosis. Transplantation 93:373-382, 2012.

* equally contributing co-first author

Editorials, Reviews, Chapters, and Other Publications
  1. Damrauer, S.M., Vora, S.R. Anatomy of the Eye and Orbit. In Chern, K. (Ed.)  Emergency Ophthalmology, McGraw Hill, New York, 2002.
  2. Vora, S.R., Damrauer, S.M., Basic Opthalmology Exam. In Chern, K. (Ed.)  Emergency Ophthalmology, McGraw Hill, New York, 2002.
  3. Damrauer, S.M., Galanter, J.M., Cardozo, D.L. Pharmacology of Dopaminergic Neurotransmission. In Golan, D.E., Tashjian, A.H., Jr., Armstrong, E.J., Galanter, J.M., Armstrong, A.W., Arnaout, R.A., and Rose, H.S. (Eds.) Principles of pharmacology. The pathophysiologic basis of drug therapy, Lippincott Williams & Wilkins, Philadelphia, 2005.
  4. Damrauer, S.M., Woo, E.Y. The sandwich approach to TAAA treatment. Endovascular Today, September 2012.
  5. McGillicuddy, F.C., Moll, H.P., Farouk, S., Damrauer, S.M., Ferran, C., Reilly, M.P. Translational studies of A20 in Athersclerosis and Casciovascular Disease. in Ferran, C. (Ed.) The Multiple Therapeutic Targets of A20, Landes Biosceince, Austin, [in press]
  6. Woo, E.Y., Damrauer, S.M. Abdominal aortic aneurysms: Open surgical treatment. in Cronewett, J.L., and Johnston, K.W. (Eds.) Rutherford’s Vascular Surgery 8th ed., Saunders Elsevier, Philadelphia, [in press].
  7. Woo, E.Y., Damrauer, S.M. Extra-thoracic Revascularization. in Mullholand, M., Hughes, S., Hawn, M., Sabel, M., Albo, D., Englesbe, M., & Dalman, R. (Eds.) Operative Techniques in Surgery, Lippincott Williams & Wilkins, Philadelphia, [in press]
Abstracts
  1. Damrauer, S.M., Mueller, T., and Perkins, D.L. Transcriptional profiling of allograft rejection. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001, Chicago, USA.
  2. Damrauer, S.M., Mueller, T., Buckley, M., Stone, J., Perkins, D.L. Robust chemokine and inflammatory response by the innate immune response after transplantation. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001, Chicago, USA.
  3. Mueller, T., Damrauer, S.M., Buckley, M., Stone, J., Perkins, D.L. Differential inflammatory and chemokine responses by the innate and adaptive immune responses after transplantation. Poster presentation at Transplant 2001, Joint American Transplant Meeting, May 20001. Chicago, USA.
  4. Damrauer, S.M., Garrigue, V., Nikolic, B., and Sykes, M. Porcine thymic tissue can support human thympoiesis that is resistant to HIV-1 mediated destruction.  Poster presentation at the Federation of Clinical Immunology Societies 3rd Annual Meeting, May 2003, Paris, France.
  5. Maccariello, E., Silva, C., Daniel, S., Damrauer, S.M., Choi, L.Y., Siracuse, J.J., Kaczmarek, E., Ferran, C. Hepatocyte growth factor upregulates A20 in renal proximal tubular epithelial cells: A potential protective preconditioning regimen in kidney transplantation. Oral presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  6. Siracuse, J.J., Fisher, M.D., Csizmadia, E., Damrauer, S.M., Choi, L.Y., da Silva, C.G., Moon, K., Maccariello, E., Daniel, S., Ferran, C. A20 prevents transplant arteriosclerosis in a model of aortic allograft. Poster presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  7. Damrauer, S.M., Fisher, M.D., Scali, S.T., Wada, H., da Silva, C.G., Csizmadia, E., Maccariello, E.R., Moon, K., Siracuse, J.J., Bolash, R., Aird, W., Daniel, S., Ferran, C. Combined anti-infammatory and anti-angiogenic functions of A20 in the vessel wall: Implications for transplant arteriosclerosis. Poster presentation at the American Transplant Congress, June 2008, Toronto, Canada.
  8. Choi, L., Sali, S., da Silva, C., Clermont, A., Csmadia, E., Fisher, M., Damrauer, S.M., Siracuse, J.J., Young, M., Benjamin, L., Daniel, S., Ferran, C. A novel anti-angiogenicf function of A20: implications in diabetic retinopathy. Poster presentation at the 15th International Vascular Biology Meeting, June 2008, Sydney, Australia.
  9. Siracuse, J.J., Fisher, M.D., Csizmadia, E., Damrauer, S.M., Choi, L.Y., da Silva, C.G., Moon, K., Maccariello, E., Daniel, S., Ferran, C. A20 protects against accelerated atherosclerosis in aortic allografts. Oral presentation at the Society for Vascular Surgery Annual Meeting, June 2008, San Diego, USA.
  10. Damrauer, S.M., Fisher, M.D., Scali, S.T., Wada, H., da Silva, C.G., Csizmadia, E., Maccariello, E.R., Moon, K., Siracuse, J.J., Bolash, R., Aird, W., Daniel, S., Ferran, C. The atheroprotective molecule A20 inhibits post-angioplasty restenosis by both anti-inflammatory and anti-angiogenic pathways. Poster presentation at the Society for Vascular Surgery Annual Meeting, June 2008, San Diego, USA.
  11. Siracuse, J.J., da Silva, C.G., Damrauer, S.M., Fisher, M.D., Studer, P., Skroch, M., Choi, L.Y., Csizmadia, E., Kaczmarek, E., Daniel, S., Ferran, C. A20's Opposite Effect on CD40 Expression in Endothelial Cells and Smooth Muscle Cells Underscores its Atheroprotective Potential. Oral presentation at the 2009 SVS Research Initiatives in Vascular Disease, April 2009, Washington D.C., USA.
  12. Siracuse, J.J., da Silva, C.G., Damrauer, S.M., Fisher, M.D., Studer, P., Skroch, M., Choi, L.Y., Csizmadia, E., Kaczmarek, E., Daniel, S., Ferran, C. Opposite effects of A20 upon CD40 expression in EC and SMC: Implication in A20’s protective effect against transplant associated vasculopathy. Poster presentation at the American Transplant Congress, May 2009, Boston, USA.
  13. Daniel, S., Kaczmarek, E., Choi, L., Fisher, M.D., Siracuse, S.S., Csizmadia, E., Damrauer, S.M., Studer, P., da Silva, C.G., Ferran, C. A20 increases the expression of endothelial and inducible nitric oxide synthases in endothelial and smooth muscle cells to protect from transplant arteriosclerosis. Poster presentation at the American Transplant Congress, May 2009, Boston, USA.
  14. da Silva, C.G., Skroch, M., Studer, P., Damrauer, S.M., Siracuse, J.J., Maccariello, E., Kaczmarek, E., and Ferran, C. The pro-proliferative effects of A20 map to the 7-Zinc finger domain: A means to define small peptides with therapeutic potential. Poster presentation at the American Transplant Congress, May 2009, Boston, USA.
  15. Damrauer, S.M., Csizmadia, E., Studer, P., Bhasin, M., DaSilva, C.G., Peterson, C.R., Ferran. C. Partial Loss of A20 (Tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysms. Poster presentation at Arteriosclerosis, Thrombosis, and Vascular Biology, April 2010, San Francisco, USA.
  16. Peterson, C., Siracuse, J.J.,Fisher, M., DaSilva. C., Csizmadia, E., Damrauer, S.M., Studer, P., Essayagh, S., Kaczmarek, E., Ferran, C. A20 Protects Vascular Allografts from Transplant Arteriosclerosis by Modulating Inflammatory and Apoptotic Responses to Skew the Immune Response. Oral presentation at the American Transplant Congress, May 2010, San Diego, USA.
  17. Studer, P., da Silva, C., Csizmadia, E., Damrauer, S.M., Peterson, C., Siracuse, J., Essayagh, S., Kaczmarek, E., Candinas, D., Stroka, D., Ferran, C. Delayed Liver Regeneration in Mice with Partial A20 Knockdown Underscores the Central Role of A20 in the Liver. Oral presentation at the American Transplant Congress, May 2010, San Diego, USA.
  18. da Silva, C., Studer, P., Csizmadia, E., Damrauer, S.M., Peterson, C., Kaczmarek, E., Essayagh, S., Candinas, D., Stroka, D., Ferran, C. Delayed Liver Regeneration in Mice with Partial A20 Knockdown Underscores the Central Role of A20 in the Liver. Poster presentation at the American Transplant Congress, May 2010, San Diego, USA.
  19. Studer, P., da Silva, C., Damrauer, S.M., Longo, C., Bhasin, M., Libermann, T., Inderbitzin, D., Candinas, D., Stroka, D., Ferran, C. Gene chip analysis of A20 expressing livers following extended resection uncovers its multiple targets that promoter liver repair and regeneration. Poster presentation at the Jahreskongress der Schweizerischen Gesellschaft für Chirurgie May 2010, Interlaken, Switzerland.
  20. Studer, P., da Silva, C., Csizmadia, E., Damrauer, S.M., Peterson, C., Kaczmarek, E., Essayagh, S., Candinas, D., Stroka, D., Ferran C. The Protective effect of A20 against severe liver ischemia reperfusion injury is abolished in PPARa-null mice. Oral presentation at the Jahreskongress der Schweizerischen Gesellschaft für Chirurgie May 2010, Interlaken, Switzerland.
  21. da Silva, C.G., Shrikhande, G., Shrikhande, G.V., Scali, S.T., Damrauer, S.M., Csizmadia, E., Matthey, M., Kaczmarek, E., Ferran, C. Glucose-mediated loss of vascular A20 contributes to accelerated atherosclerosis in diabetes. Oral presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, Boston MA.  September 2010.
  22. Peterson, C.R., Siracuse, J.J., Fisher, M.D., da Silva, C.G., Csizmadia, E., Damrauer, S.M., Studer, P., Essayagh, S., Kaczmarek, E., Ferran, C. Vascular remodeling in Transplant Arteriosclerosis: the role of A20. Oral presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, Boston MA.  September 2010.
  23. Damrauer, S.M., Peterson, C.R., Studer, P., Marusyk, V.L., Csizmadia, E., da Silva, C.G., Ferran, C. Partial Loss of A20 (tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysm. Poster presentation at the International Society for Applied Cardiovascular Biology (ISACB) 12th Biannual Meeting, Boston MA.  September 2010.
  24. Damrauer, S.M., Peterson, C.R., Studer, P., Marusyk, V.L., Csizmadia, E, da Silva, C.G., Ferran C. Partial Loss of A20 (Tnfaip3) Promotes Resistance to Abdominal Aortic Aneurysms Through Altering Smooth Muscle Cell Differentiation. Oral presentation American College of Surgeons 96th Annual Clinical Congress, Washington DC, October 3-7, 2010.

Dr. Scott Damrauer

 
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