Muhammad Umar Jawad - Housestaff Profile

Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

Muhammad.Jawad@uphs.upenn.edu

Dr. Jawad is interested in pursuing a career as an orthopedic oncologic surgeon scientist. Having completed his research training for 5 years, he is working towards completing his clinical training.


Appointments
2012 - present	Assistant Instructor in Surgery


Education/Training
2011 - 2012	Stem Cell Biology & Orthopedic Oncology Cedars-Sinai Los Angeles

2010 - 2011	Stem Cell Biology Stanford.

2007 - 2010	Sarcoma Biology and Orthopedic Oncologic Epidemiology University of Miami

2004 - 2007	House Officer Orthopedic Surgery Shaukat Khanum Cancer Hospital and Research Center

1999 - 2004	Aga Khan University - MBBS

Memberships/Societies

American Association for Advancement of Science (AAAS) ID#20248517
American Academy of Cancer Research (AACR) ID # 154284
American Academy of Orthopedic Surgery (AAOS) – Presenter
Orthopedic Research Society (ORS) – Presenter

Research

2007 - 2012
Basic Science: Dr. Jawad's research has focused on the role of Matrix Metalloproteinase 1 in sarcoma biology. He has identified the cellular source of MMPs in human sarcomas. He also worked on a murine model of human osteosarcoma characterizing the effects of MMP-1 silencing on local tumor growth and distant metastasis. He used Di-I to investigate the interaction of GFP labeled sarcoma cells and the vessel bed in sarcoma model. He further used the CAM model to look at the effects of MMP production on permeability and stability of vascular bed in sarcomas.

During his time at Stanford, he investigated the homing characteristics of systemically injected stem cells in the presence of a non-critical sized bone defect. He further investigated the effects of anti-sclerostin antibody (Amgen) on homing characteristics of systemically injected stem cells. He continued his investigation on stems cells at Cedars-Sinai using the iPS-Cells and human embryo forebrain derived cell line.

Clinical Science: He has published population based outcome studies for various bone sarcomas using the NCI SEER database. During his time at Cedars-Sinai he looked at the use of tripolar constrained device for hip reconstruction for proximal femoral resections for oncologic reasons.

Publications

Basic Science

Matrix Metalloproteinase1: Role in Sarcoma Biology Jawad MU, Garamszegi N, Garamszegi SP, Diez J,
Correa-Medina M, Wen R, Scully SP, PLoS One 2010 Dec 8th, 5(12): e14250
Effects of Sclerostin Antibody on Healing of a Non-Critical sized Femoral Bone Defect, Jawad MU, Fritton KE, Ma T, Ren PG, Ke Z, Babij, P, Genovese MC, Goodman SB, E pub 8th Aug, 2012 Journal of Orthopaedic Research DOI: 10.1002/jor.22186
MC3T3-E1 Osteoprogenitor Cells Migrate Systemically to a Bone Defect and Enhance Bone Healing
Gibon E, Batke B, Jawad MU, Fritton K, Rao A, Yao Z, Biswal S, Gambhir S, Goodman SB, Tissue Engineering Part A 2012 May; 18(9-10):968-73

Clinical Science

Ewing Sarcoma demonstrates Racial Disparities in incidence and Gender related differences in outcome
An analysis of 1631 cases from the SEER Database (1973-2005) Jawad MU, Cheung MC, Min E, Schneiderbauer MM, Koniaris LG, Scully SP, Cancer, 2009 Aug 1;115(15):3526-36.
Primary Lymphoma of Bone in Adult Patients, Jawad MU, Schneiderbauer MM, Cheung MC, Min
E, Koniaris LG, Scully SP, Cancer, 2010 Feb. 15th; 116(4):871-9
Malignant Sarcoma of the Pelvic Bones: Treatment Outcomes and Prognostic factors vary by histopathology, Jawad MU, Haleem AA, Scully SP, Cancer, 2010, 8th Nov., Epub
Osteosarcoma: Improvement in survival limited to patients with high-grade osteosarcoma, Jawad MU, Cheung MC, Koniaris LG, Scully SP, Journal of Cancer Research and Clinical, Oncology. 2010, Jun 1, Epub
Surgery significantly Improves survival in patients with Chordoma, Jawad MU, Scully SP, Spine (Phila Pa 1976), 2010 Jan 1;35(1):117-123.
Prognostic factors for survival in patients with Epithelioid Sarcoma: 441patients from the SEER database, Jawad MU, Extein J, Min E, Scully SP, Clinical Orthop. and Related Research, 2009 Nov;467(11):2939-48.
Skeletal Plasmacytoma: Progression of Disease and Impact of Local Treatment; an analysis of SEER database, Jawad MU, Scully SP, Journal of Hematology and Oncology, 2009, 2:41
Enneking Classification: Benign and Malignant tumors of the musculoskeletal system, Jawad MU, Scully SP, Clinical Orthop. and Related Research, 2010; 468(7):2000-2
Mirels’ Classification: Metastatic disease in long bones; Impending pathological fracture, Jawad MU, Scully SP, Clinical Orthop. and Related Research, 2010; 468(10):2825-7.
Crowe’s Classification: Arthoplasty in developmental Dysplasia of the Hip, Jawad MU, Scully SP
Clinical Orthop. and Related Research, 2011, Jan; 469(1):306-8
Ficat Classification: Avascular Necrosis of the Femoral Head, Jawad MU, Haleem AA, Scully SP, Clinical Orthop. and Related Research, July 4th, 2012 Epub
Morphology of proximal femur in a Pakistani population Investigators, Umer M, Sepah YJ, Wazir A, Niazi AU, Ahmed M, Jawad MU, Journal of Orthopedic Surgery Hong Kong 2010 Dec.; 18(3): 279-81.
Acetabular Morphometery and prevalence of hip dysplasia in South-Asian population Investigators, Umer M, Sepah YJ, Asif S, Azam I, Jawad MU, Orthopedic Reviews 2009, Vol. 1, e:10.