Kathreen P. Lee - Housestaff Profile

Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

kathreen.lee@uphs.upenn.edu

Dr. Lee is in her first year of research in Dr. Brian Czerniecki's lab. Currently, she is focusing on identifying and investigating the role of biomarkers in DCIS and evaluating their potential as targets for immunotherapy.


Appointments
2009 - present	Assistant Instructor in Surgery

2012 - present	Postdoctoral Researcher


Education/Training
2005 – 2009	MD - Boston University School of Medicine Boston, Massachusetts

1999 - 2001	MA - Rice University Houston, Texas

1993 - 1997	BA in Biology - Harvard University Cambridge, Massachusetts


Memberships/Societies
08/2005 – 05/2009	D. Hayes Agnew Surgical Society Philadelphia, Pennsylvania Vice President, 2008-2009

Research

06/2002 - 08/2002
Baylor College of Medicine, Dept Molecular Physio, Houston, TX
Research Assistant, Professor Charles L. Densmore, PhD
Received the Advanced Research/Advanced Technology Grant awarded by the Texas Higher Education Coordinating Board and spent three months working for the Technology Development Transfer project at Baylor which was aimed at developing aerosol gene delivery technology for clinical application in the possible future treatment of osteosarcoma metastases to the lungs in human pediatric patients. This project collaborated with the lab of Dr. Eugenie Kleinerman of M.D. Anderson. Helped design and construct various plasmids to optimize the persistence of gene expression, particularly IL-12 and p53 genes delivered to the lungs via nebulized aerosol.

06/2001 - 08/2001
M.D. Anderson Cancer Center, Dept Cancer Biology, Houston, TX
Research Assistant, Professor Eugenie Kleinerman, MD
Received the Advanced Research/Advanced Technology Grant awarded by the Texas Higher Education Coordinating Board and worked for three months in Dr. Kleinerman's lab to help optimize novel aerosol delivery systems for gene therapy in treating human osteosarcoma metastases to the lungs in animal models. My task was to optimize delivery of PEI based formulations of IL-12 and p53 genes through aerosol delivery and to conduct PCR analysis of anti-tumor gene expression in tumor and non-tumor tissues.

Publications

Kang MS, Lee HJ, Lee JH, Lee KP, Kelley MJ, Won YJ, Kim ST, Park JG. Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA. International Journal of Cancer.1996 Sep; 67(6): 898-902. Cited in PubMed; PMID: 8824565.