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Lea Lowenfeld, M.D.
General Surgery Resident

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

Lea.Lowenfeld@uphs.upenn.edu

 

Dr. Lowenfeld is a PGY-5 general surgery resident.  She graduated from Cornell University with a BA in Philosophy and received her medical degree from the University of Pennsylvania.  She has completed three years of general surgery clinical training and is currently a Henle Post-Doctoral Research Fellow in the laboratory of Dr Brian Czerniecki.  She is (1) investigating in vitro antigen-specific T-cell expansion for adoptive T-cell transfer in breast cancer patients receiving concurrent DC vaccination and (2) identifying immunogenic cMET epitopes for use in cancer immunotherapy. She is also the current Chair of the Resident Executive Council. She plans to pursue a career in surgical oncology.

 
Appointments
2014 – present Henle Post-Doctoral Research Fellow
 
2011 - present Assistant Instructor in Surgery
 
 
 
 
 
 
 
 
 
Education/Training
2007 - 2011 MD - University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2003 - 2007 BA - Philosophy
Cornell University, Ithaca, New York
 
 
 
 
 
 
 
Memberships/Societies
2014 - present  American College of Surgeons
 
2014 - present Association of Women Surgeons
 
2014 - present Society for Surgical Oncology
 
2007 Phi Beta Kappa, Cornell University
 
2004 - 2007 College Scholar, Cornell University
 
 
 
Research
07/2014-present
University of Pennsylvania, Department of Surgery, Philadelphia, Pennsylvania
Harrison Department of Surgical Research, PI: Dr. Brian J. Czerniecki
(1) investigating in vitro antigen-specific T-cell expansion for adoptive T-cell transfer in breast cancer patients receiving concurrent DC vaccination and (2) identifying immunogenic cMET epitopes for use in cancer immunotherapy
 
07/2010 – 05/2011
University of Pennsylvania, Trauma Center at Penn, Philadelphia, Pennsylvania
Research Student, PI: Dr. Carrie A. Sims
Prospective study looking at the impact of new management guidelines on the development of chest tube complications following thoracic injury
 
01/2006 – 05/2007
Cornell University, Neurobiology Department, Ithaca, New York
Research Assistant, PI: Dr. Christiane Linster
Study of the olfactory mechanisms underlying learning and memory in mice with regard to the role of NMDA receptors in social recognition
 
01/2006 – 05/2007
Cornell University, Philosophy Department, Ithaca, New York
Research Assistant, PI: Dr. Tamar Gendler
Student editor of an introductory philosophy textbook.
 

05/2005 – 08/2005
Columbia University, Sergievsky Center, New York, New York
Research Assistant, PI: Dr. Yaakov Stern
Study of error correction and meta-cognition errors in young and elderly adults.

 
Publications
 
Original Articles
  1. Datta J, Terhune JH, Lowenfeld L, Cintolo JA, Xu S, Roses RE, Czerniecki BJ. Optimizing Dendritic Cell-Based Approaches for Cancer Immunotherapy. Yale J Biol Med.2014; 87(4): 491-518.
  2. Lowenfeld L, Datta J, Lewis R, Jr., McMillan M, Mamtani R, Damjanov N, Chandrasekhara V, Karakousis G, Drebin J, Fraker D, et al. Multimodality Treatment of T4 Gastric Cancer in the United States: Utilization Trends and Impact on Survival. Annals of Surgical Oncology 2015:1-10.
  3. Datta J, Berk E, Xu S, Fitzpatrick E, Rosemblit C, Lowenfeld L, Goodman N, Lewis DA, Zhang PJ, Fisher C, Roses RE, DeMichele A, Czerniecki BJ. Anti-HER2 CD4+ T-helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancer. Breast Cancer Res. 2015; 17(1):71
  4. Lowenfeld L, Xu S, Czerniecki BJ. CD4+ Th1 to the rescue in HER-2+ breast cancer. OncoImmunology. 2015 (epub)
Abstracts
  1. Lowenfeld L, Datta JFitzpatrick E, Xu S, Czerniecki BJ. Anti-HER2 CD4 Th1 can be rapidly expanded from breast cancer patients vaccinated with DC1. Society of Surgical Oncology 68th Annual Cancer Symposium, March 2015.
  2. Datta JXu S, Berk E, Lowenfeld L, Fitzpatrick E. Depressed anti-HER2 CD4 Th1 responses correlate with residual disease following neoadjuvant therapy in HER2+ breast cancer patients and can be restored by dendritic cell vaccination. American Association of Cancer Research, April 2015.
  3. Fracol M, Datta J, Xu S, Lowenfeld L, Fitzpatrick E, Mies C, Zhang PJL, Roses RE, Fisher C, Czerniecki BJ. HER2 peptide-specific immunogenicity correlates with pathologic responses following HER2-pulsed dendritic cell vaccination for early breast cancer. American Association of Cancer Research, April 2015.
Presentations
  1. Stitelman D, Lowenfeld L, Pechet T, Murayama K.. Laparoscopic Resection of Gastrointestinal Stromal Tumors of the Stomach. Presented at The Southwestern Surgical Congress 2011, Ko Olina, Hawaii
  2. Isserman JA, Mary L, Lowenfeld L, Tolstoy N, Sims CA. Emergency Research: Does a History of Trauma Resuscitation Influence Patient Attitudes? Won Best Undergraduate Research Prize at Sackler Faculty of Medicine Research Symposium 2011. Sackler Medical School at Tell Aviv University, Israel.
  3. Datta J, Xu S, Terhune JH, Lowenfeld L, Rosemblit C, Berk E, Fitzpatrick E, Roses RE, Czerniecki BJ. Identification of Novel Class II-Promiscuous HER3-Derived CD4+ Peptides for Cancer Immunotherapy, American Surgical Congress, February 2015.
  4. Datta JXu S, Berk E, Lowenfeld L, Wang X, Fitzpatrick E, Lewis D, Goodman N, DeMichele A, Czerniecki BJ. Anti-HER2 CD4 T-cell Immunity Strongly Correlates with Pathologic Complete Response to Neoadjuvant Therapy in HER2+ Breast Cancer. Society of Surgical Oncology 68th Annual Cancer Symposium, March 2015.
  5. Lowenfeld L, Zaheer S, Fracol M, Datta J, Xu S, Fitzpatrick E, DeMichele A, Zhang PJ, McDonald E, Cerniecki BJ. Combination anti-estrogen therapy and anti-HER2 dendritic cell vaccination improves pathologic complete response in ER+/HER2+ DCIS patients. Society of Surgical Oncology 69th Annual Cancer Symposium, March 2016. (accepted)
Book Chapters
  1. Lowenfeld L, Morris JB, Resnick A. Hernias. The Surgical Review. Lippincott Williams & Wilkins, 4th ed. 2014 (in press)
  2. Czerniecki BJ, Nocera N, Lowenfeld L, Showalter L, Koski G. Trends in Breast Cancer Prevention. Springer 2015 (in press)
 
Awards
 
 
 
 
 
 
 
 
 
 

Dr. Lea Lowenfeld

 
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