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John W. MacArthur, M.D.
General Surgery Resident

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

john.macarthur@uphs.upenn.edu

 

John W. MacArthur, M.D., completed his undergraduate training at Fordham University and received his medical degree from Columbia University, College of Physicians and Surgeons. He is currently a 5th year general surgery resident, having completed three years as a surgical research fellow in the Y. Joseph Woo Cardiovascular Research Laboratory. His primary research interest involves mechanisms of angiogenesis after MI and investigating the biomechanical inefficiencies of ventricular myoctes post-infarction.  He will continue his training as a cardiac surgery fellow at Stanford University Medical Center in 2016, after which he will pursue a career in academic cardiac surgery.

 
Appointments
2015 - present Instructor in Surgery
 
2011 - 2014 Postdoctroral Researcher
 
2008 - 2015 Assistant Instructor in Surgery
 
 
 
 
 
 
 
 
Education/Training
1/2014 - 6/2014 Stanford Hospital and Clinics
Visiting Scholar, Department of Cardiothoracic Surgery
Stanford, California
 
2012 - 2014 University of Pennsylvania, Philadelphia, Pennsylvania
Masters in Translational Research
 
2004 - 2008 Columbia University, College of Physicians and Surgeons, New York, New York
Doctor of Medicine 2008
 
2000 - 2004 Fordham University, New York, New York
Bachelor of Science 2004
Major: Biological Sciences
Minor: Economics
 
Memberships/Societies
  • American College of Surgeons, Resident Member
  • Association for Academic Surgery, Resident Member
  • American Heart Association, Resident Member
  • International Society of Heart Research, Resident Member
  • Institute for Translational Medicine and Therapeutics, Associate Member
 
 
 
 
 
Research
 
 
 
 
 
 
 
 
 
 
 
Publications
Peer Reviewed Publications
  1. Hiesinger W, Vinogradov SA, Atluri P, Fitzpatrick JR 3rd, Frederick JR, Levit RD, McCormick RC, Muenzer JR, Yang EC, Marotta NA, MacArthur JW, Wilson DF, Woo YJ. Oxygen-dependent quenching of phosphorescence used to characterize improved myocardial oxygenation resulting from vasculogenic cytokine therapy. J App Phys. 2011;110(5):1460-5.
  2. Hiesinger W, Perez-Aguilar JM, Atluri P, Marotta NA, Frederick JR, Fitzpatrick JR, McCormick RC, Muenzer JR, Yang EC, Levit RD, Yuan LJ, MacArthur JW, Saven JG, Woo YJ. Computational protein design to reengineer stromal cell- derived factor 1α generates an effective and translatable angiogenic polypeptide analog. Circulation. 2011;124:S18-26.
  3. Woo YJ, MacArthur JW.  Simplified non-resectional leaflet-remodeling mitral valve repair for degenerative mitral regurgitation.  J Thorac Cardiovasc Surg 2012;143:749-53.
  4. Atluri P, MacArthur JW.  Novel strategy to improve end-organ function with pulsatile cardiopulmonary bypass.  Circ J. 2012;76:1087-8.
  5. Atluri P, Ullery BW, MacArthur JW, Goldstone AB, Fairman AS, Hiesinger W, Acker MA, Woo YJ.  Rapid onset of fulminant myocarditis portends a favorable prognosis and the ability to bridge mechanical circulatory support to recovery.  Eur J Cardiothorac Surg.  2013;43:379-82.
  6. MacArthur JW, Trubelja A, Shudo Y, Hsiao P, Fairman AS, Yang E, Hiesinger W, Sarver JJ, Atluri P, Woo YJ.  Mathematically-engineered stromal cell-derived factor 1alpha stem cell cytokine analogue enhances mechanical properties of infarcted myocardium.  J Thorac Cardiovasc Surg.  2013;145:278-84.
  7. Kaczorowski DJ, MacArthur JW, Howard J, Kobrin D, Fairman A, Woo YJ.  Quantitative evaluation of change in coexistent mitral regurgitation after aortic valve replacement.  J Thorac Cardiovasc Surg.  2013;145:341-8.
  8. Goldstone AB, Atluri P, Szeto WY, Trubelja A, Howard JL, MacArthur JW, Newcomb C, Donnelly JP, Kobrin DM, Sheridan MA, Powers C, Gorman RC, Gorman JH, Pochettino A, Bavaria JE, Acker MA, Hargrove WC, Woo YJ.  Minimally invasive approach provides at least equivalent results for surgical correction of mitral regurgitation: A propensity matched comparison.  J Thorac Cardiovasc Surg. 2013;145:748-56.
  9. Woo YJ, MacArthur JW.  Posterior ventricular anchoring neochordal repair of degenerative mitral regurgitation efficiently remodels and repositions posterior leaflet prolapse.  Eur J Cardiothorac Surg.  2013; Feb:epub.
  10. Atluri P, Goldstone AB, Kobrin DM, Cohen JE, MacArthur JW, Howard JL, Jessup ML, Rame JE, Acker MA, Woo YJ.  Ventricular assist device implant in the elderly is associated with increased, but respectable risk – a multi-institutional study.  Ann Thorac Surg.  2013;96(1):141-7.
  11. Atluri P, Goldstone AB, Fairman AS, MacArthur JW, Shudo Y, Cohen JE, Acker AL, Hiesinger W, Howard JL, Acker MA, Woo YJ.  Predicting right ventricular failure in the modern, continuous flow left ventricle assist device era.  Ann Thorac Surg.  2013;96(3):857-64.
  12. MacArthur JW, Cohen JE, Goldstone AB, Fairman AS, Edwards BB, Hornick M, Atluri P, Woo YJ.  Nonresectional single-suture leaflet remodeling for degenerative mitral regurgitation facilitates minimally invasive mitral valve repair.  Ann Thorac Surg.  2013;95:1603-6.
  13. Shudo Y, Cohen JE, MacArthur JW, Atluri P, Hsiao P, Yang E, Fairman A, Trubelja A, Patel J, Miyagawa S, Sawa Y, Woo YJ.  Spacially-oriented, temporally-sequential SMC-EPC bi-level cell sheet neovascularizes ischemic myocardium.  Circulation.  2013;128:S59-68.
  14. Atluri P, Trubelja A, Fairman A, Hsiao P, MacArthur JW, Cohen JE, Shudo Y, Frederick JR, Woo YJ.  Normalization of post-infarct biomechanics utilizing a novel tissue engineered angiogenic construct.  Circulation.  2013;128:S95-104.
  15. MacArthur JW, Purcell BP, Shudo Y, Cohen JE, Fairman A, Trubelja A, Patel J, Hsiao P, Yang E, Lloyd K, Hiesinger W, Atluri P, Burdick JA, Woo YJ.  Sustained release of engineered stromal cell-derived factor 1-alpha from injectable hydrogels effectively recruits endothelial progenitor cells and preserves ventricular function following myocardial infarction.  Circulation.  2013;128:S79-86.
  16. Atluri P, Fairman AS, MacArthur JW, Goldstone AB, Cohen JE, Howard JL, Zalewski CM, Shudo Y, Woo YJ.  Continuous flow left ventricular assist device implant significantly improves pulmonary hypertension, right ventricular contractility, and tricuspid valve competence.  J Card Surg. 2013;28:770-5.
  17. MacArthur JW, Cohen JE, McGarvey J, Shudo Y, Patel JB, Trubelja A, Fairman A, Edwards BB, Hung G, Goldstone AB, Hiesinger W, Atluri P, Wilensky RL, Pilla J, Gorman JH, Gorman RC, Woo YJ.  Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1-alpha analogue in a translational ovine myocardial infarction model.  Circ Res. 2014;114:650-9.
  18. Trubelja A, MacArthur JW, Sarver JJ, Cohen JE, Hung G, Shudo Y, Fairman AS, Patel JB, Edwards BB, Damrauer SM, Hiesinger W, Atluri P, Woo YJ.  Bioengineered SDF-1alpha analogue delivered as an angiogenic therapy significantly restores viscoelastic material properties of infarcted cardiac muscle.  J Biomech Eng. 2014;136.
  19. Cohen JE, Purcell BP, MacArthur JW, Mu A, Shudo Y, Patel JB, Bruaslis CM, Trubelja A, Fairman AS, Edwards BB, Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, Burdick JA, Woo YJ.  A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.  Circ Heart Fail.  2014;7:619-26.
  20. Atluri P, Gaffey A, Howard J, Phillips E, Goldstone AB, Hornsby N, MacArthur JW, Cohen JE, Gutsche J, Woo YJ.  Combined heart and liver transplantation can be safely performed with excellent short and long term results.  Ann Thorac Surg.  2014;98:858-62.
  21. Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ.  Tissue engineered, hydrogel based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function.  J Thorac Cardiovasc Surg.  2014;148:1090-8.
  22. Goldstone AB, Howard JL, Cohen JE, MacArthur JW, Atluri P, Kirkpatrick JN, Woo YJ.  Natural history of coexistant tricuspid regurgitation in patients with degenerative mitral valve disease: implications for future guidelines.  J Thorac Cardiovasc Surg.  2014;148:2802-9.
  23. Hiraoka A, Cohen JW, Shudo Y, MacArthur JW, Howard JL, Fairman AS, Atluri P, Kirkpatrick JN, Woo YJ.  Evaluation of late aortic insufficiency with continuous flow left ventricular assist device.  Eur J Cardiothoracic Surg.  2015 (Epub).
  24. Shudo Y, Cohen JE, MacArthur JW, Goldstone AB, Hiroako A, Howard J, Fairman AS, Patel J, Edwards BB, Atluri P, Woo YJ.  Non-resectional leaflet remodeling mitral valve repair preserves leaflet mobility: A quantitative echocardiographic analysis of mitral valve configuration.  Int J Cardiol.  2015;186:16-18.
  25. Goldstone AB, Cohen JE, Howard JL, Edwards BB, Acker AL, Hiesinger W, MacArthur JW, Alturi P, Woo YJ.  A repair all strategy for degenerative mitral valve disease safely minimizes unnecessary replacement.  Ann Thorac Surg.  2015;99:1983-91.
  26. Shudo Y, Cohen JE, MacArthur JW, Trubelja A, Patel J, Edwards BB, Hung G, Fairman AS, Brusalis C, Hiesinger W, Atluri P, Hiraoka A, Miyagawa S, Sawa Y, Woo YJ, Goldstone A, Otsuru S.  A tissue engineered chondrocyte cell-sheet induces extracellular matrix modification to enhance ventricular biomechanics and attenuate myocardial stiffness in ischemic cardiomyopathy.  Tissue Eng Part A.  2015; Epub ahead of print.
  27. Rodell CB, MacArthur JW, Dorsey SM, Wade RJ, Woo YJ, Burdick JA.  Shear-thinning supramolecular hydrogels with secondary autonomous covalent crosslinking to modulate viscoelastic properties in vivo.  Adv Funct Mater.  (Accepted).
Chapters
  1. MacArthur JW, Woo YJ.  “Bone marrow cells and their role in repair after myocardial infarction” in  Cardiac Regeneration and Repair, Vol I.: Pathology and Therapies.  Eds. RK Li, RD Weisel.  Cambridge: Woodhead Publishing, 2014; 236-46.
 
Awards
2013 Vivien Thomas Young Investigator Award
American Heart Association Council on Cardiovascular Surgery and Anesthesia
Scientific Sessions 2013
 
 
 
 
 
 
 
 

Dr. JW MacArthur

 
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