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Benjamin J. Shin, M.D.
Radiology

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

benjamin.shin@uphs.upenn.edu

 

 

Dr. Shin's previous research projects mainly involved interventional neuro-oncology and characterization of related signal transduction pathways in brain tumor stem cells.  He has taken a year off between his third and fourth year of medical school for research under Dr. John Boockvar, where he investigated the role of intra-arterial chemotherapy in the treatment of recurrent high grade gliomas.  Concurrently, he had conducted basic science research on the PP2A phosphatase in Glioblastoma Multiforme (GBM) stem cells; which found that the PP2A phosphatase protects GBM stem cells under hypoxia.  In addition to interventional research, he has spearheaded several projects involving the use of CT perfusion for patients with subarachnoid hemorrhage. 

 
Faculty Appointments
2012 - present

Assistant Instructor in Surgery

 
 
 
 
 
 
 
 
 
Education/Training
2007 – 2012 Weill Cornell Medical School
Doctor of Medicine (MD)
 
2003 – 2007 Cornell University
BS in Chemical Engineering
 
 
 
 
 
Memberships/Societies
 
 
 
 
 
 
 
 
 
Research
2011 - 2012 NewYork-Prebysterian Hospital  
 
  • Research on the use of CT perfusion for vasospasm evaluation in patients with aneurysmal subarachnoid hemorrhage.
  • Primary Investigator: Dr. Pina Sanelli, Department of Radiology
 
2010 - 2011 NewYork-Prebysterian Hospital
 
  • Research on intra-arterial chemotherapy for malignant glioma and also on the role of PP2A phosphatase in brain tumor stem cells.
  • Primary Investigator: Dr. John Boockvar, Brain Tumor Research Group
 
2010 - 2011 NewYork-Prebysterian Hospital - Brain Tumor Research Group       
 
  • Research on an in situ expandable PEEK spacer for lumbar fusion and wrote several reviews on neuronavigation for spinal surgery.
  • Primary Investigator: Dr. Roger Härtl, Brain and Spine Center
 
Summer 2008 Weill Cornell Medical School
 
  • Conducted research on evaluating the neuroprotective effects of nicotinamide riboside on rat dopaminergic cells treated with MPP+.
  • Primary Investigator: Dr. Flint Beal, Neurodegenerative Disorders Laboratory
 
Summers
2007 & 2005
National Institutes of Health
 
  • Investigated the association of nitrite and hemoglobin and determined the effect of ascorbic acid on nitric acid metabolism in human red blood cells.
  • Primary Investigator: Dr. Alan Schechter, Molecular Medicine Branch
 
Publications
  1. Shin, B.J., A.R. James, I.U. Njoku, and R. Härtl. (June 2012). “Pedicle Screw Navigation: A Systematic Review and Meta-Analysis of Perforation Risk for Computer Navigated versus Freehand Insertion.” Journal of Neurosurgery: Spine.  PMID: 22724594.
  2. Nagineni, V.V., A.R. James, M. Alimi, C. Hofstetter, B.J. Shin, I. Njoku, A.J. Tsiouris, R. Härtl. (June 2012). “Silicate-Substituted Calcium Phosphate Ceramic Bone Graft Replacement for Spinal Fusion Procedures.” Spine. PMID: 22744618.
  3. Jeon, J., I. Kovanlikaya, J.A. Boockvar, X. Mao, B.J. Shin, …, H.A. Riina, J. Tsiouris. (May 2012). “Metabolic Response of Glioblastoma to Super-Selective Intra-Arterial Cerebral Infusion of Bevacizumab: An In Vivo by Proton Magnetic Resonance Spectroscopic Imaging Study.” American Journal of Neuroradiology. PMID: 22576886.
  4. Shin, B.J., J.K. Burkhardt, H.A. Riina, J.A. Boockvar. (Apr 2012). “Superselective Intra-arterial Cerebral Infusion of Novel Agents after Blood Brain Disruption for the Treatment of Recurrent Glioblastoma Multiforme: A Technical Case Series.” Neurosurgery Clinics of North America 23(2): 323-329. PMID: 22440875.
  5. Banu, M.A., B.J. Shin, J.A. Boockvar. (Apr 2012). “Dissecting the Perivascular Stem-Cell Niche: Can We Take Tumor Recurrence Down a NOTCH?” Neurosurgery 70(4): N18-9. PMID: 22426056.
  6. Burkhardt, J.K., O. Bozinov, J. Nürnberg, B.J. Shin, C.M. Woernle, N.A. Ulrich, H. Bertalanffy. (Mar 2012). “Neurosurgical considerations on highly eloquent brainstem cavernomas in pregnant patients.” Clinical Neurology and Neurosurgery. PMID: 22425367.
  7. Hofstetter, C.P., J.K. Burkhardt, B.J. Shin, …, E.C. Cameron, E. Holland, J.A. Boockvar. (Jan 2012). “Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.” PLoS ONE 7:e30059.  PMID: 22253878.
  8. Burkhardt, J.K., H.A. Riina, B.J. Shin, …, A.J. Tsiouris, J.A. Boockvar. (Jan 2012). “Intra-Arterial Delivery of Bevacizumab after Blood Brain Barrier Disruption for the Treatment of Recurrent Glioblastoma: Progression Free Survival and Overall Survival.” World Neurosurgery 77(1): 130-4. PMID: 22405392.
  9. Shin, B., Burkhardt J.K., J. Boockvar. (Oct 2011). “Glioblastoma Multiforme Stem-Like Cells and Hypoxia: The Novel Role of HAF.” Neurosurgery 69(4):N21. PMID: 21900808.
  10. Burkhardt, J.K., H.A. Riina, B.J. Shin, …, J.A. Boockvar. (Sept 2011). "Intra-arterial Chemotherapy for Malignant Gliomas: A Critical Analysis." Interv Neuroradiol 17(3): 286-95. PMID: 22005689.
  11. Burkhardt, J.K., B.J. Shin, C.D. Schlaff, H.A. Riina, J.A. Boockvar. (Sept 2011). “Cost Analysis of Intra-arterial versus Intra-venous Delivery of Bevacizumab for the Treatment of Recurrent Glioblastoma Multiforme.” J Exp Ther Oncol 9(3): 183-6. PMID: 22070049.
  12. Gürsel, D.B., B.J. Shin, …, J.A. Boockvar. (Jun 2011). “Glioblastoma Stem-Like Cells - Biology and Therapeutic Implications.” Cancers 3: 2655-2666. PMID: 21796273.
  13. Burkhardt J.K., B.J. Shin, J.A. Boockvar. (Jun 2011). “Neural Stem Cells and Glioma Stem-Like Cells Respond Differently to Chemotherapeutic Drugs: Selectivity at the Cellular Level.” Neurosurgery 68:N21-N22. PMID: 21778947.
  14. Hofstetter, C. P., B. J. Shin, …, V.K. Anand, J.A. Boockvar, T.H. Schwartz. (Apr 2011). "Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas." Neurosurg Focus 30(4): E10. PMID: 21456921.
Abstracts
  1. Shin, B.J., …, P. Sanelli, “Selection of an Arterial Input Function Distal to Vasospasm Does Not Affect CT Perfusion Data in Aneurysmal Subarachnoid Hemorrhage” accepted for presentation at the ASNR 50th Annual Meeting, New York, NY, April 2012. Oral Presentation.
  2. Gursel, D., J.K. Burkhardt, B.J. Shin, and J.A. Boockvar, “Bevacizumab Induces Apoptosis and p53 Overexpression in Glioblastoma Stem Cells” accepted for presentation at the Congress of Neurological Surgeons 2011 Annual Meeting, Washington D.C., October 2011.  Poster Presentation.
  3. Schlaff, C.D., J.K. Burkhardt, B.J. Shin, H.A. Riina, and J.A. Boockvar, “Cost Analysis of Intra-arterial versus Intra-venous Delivery of Bevacizumab for the Treatment of Recurrent Glioblastoma Multiforme” accepted for presentation at the Congress of Neurological Surgeons 2011 Annual Meeting, Washington D.C., October 2011.  Poster Presentation.
  4. Jeon, J., I. Kovanlikaya, J.A. Boockvar, X. Mao, B.J. Shin, …, H.A. Riina, J. Tsiouris, “Proton MR Spectroscopy: Assessing the Metabolic Effects of Super-Selective Intra-Arterial Cerebral Infusion of Bevacizumab in Treatment of Glioblastoma” presented at the ASNR 49th Annual Meeting & NER Foundation Symposium, Seattle, WA, June 2011.  Oral Presentation.
  5. Shin, B.J., C.P. Hofstetter, R. Härtl, “Early Experience with Expandable PEEK Spacers for Interbody Fusion for Degenerative Lumbar Disease” presented at the Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Phoenix, AZ, March 2011.  Poster Presentation.

Dr. Benjamin Shin

 
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