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Andrew J. Sinnamon, M.D.
General Surgery Resident

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Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)


Andrew recently finished his third year of general surgery residency and is in his first year of research under Dr. Giorgos Karakousis.  He is also pursuing a Masters in Clinical Epidemiology during this time. His interests include oncologic and gastrointestinal surgery and intends to pursue a career in surgical oncology.

2016 - present Postdoctoral Researcher
2013 - present Assistant Instructor of Surgery
2009 - 2013 MD - University of Pennsylvania School of Medicine
2005 - 2009  BS - Biochemistry and Molecular Biology
Pennsylvania State University
  • American College of Surgeons
  • Phi Beta Kappa
University of Pennsylvania School of Medicine 2016 – Present
Giorgos Karakousis, MD, Principal Investigator and Department of Endocrine and Oncologic Surgery
Research fellow currently involved in clinical research projects concerning melanomas, sarcomas, and other tumors.
University of Pennsylvania School of Medicine 2012 – 2013
Rachel Kelz, MD, MSCE, Principal Investigator
Investigated gender-related differences in surgical outcomes following lower extremity revascularization.
University of Pennsylvania School of Medicine 2010
Lawrence Brass, MD, PhD, Principal Investigator
Studied the intracellular regulation pathways of platelet activation. Research was supported by the 2010 American Society of Hematology Trainee Award and was presented as a poster at the 2010 American Society of Hematology Annual Meeting.
Pennsylvania State University 2006 – 2009
B. Frank Pugh, PhD, Thesis Advisor
Studied genomic binding locations of the known transcription factors of Saccharomyces cerevisiae using chromatin immunoprecipitation coupled to DNA microarrays (ChIP-chip). Research culminated in honors thesis, entitled “Genome-Wide Movement of Transcriptional Machinery in Response to Heat Shock”
  1. Venters BJ, Wachi S, Mavrich TN, Andersen BE, Jena P, Sinnamon AJ, Jain P, Rolleri NS, Jiang C, Hemeryck-Walsh C, Pugh BF. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell. 2011 Feb 18
  2. Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 2012 Feb 23
  3. Bartlett EK, Gimotty PA, Sinnamon AJ, Wachtel H, Roses RE, Schuchter L, Xu X, Elder DE, Ming M, Elenitsas R, Guerry D, Kelz RR, Czerniecki BJ, Fraker DL, Karakousis GC. Clark level risk stratifies patients with mitogenic thin melanomas for sentinel lymph node biopsy. Ann Surg Oncol. 2014 Feb;21(2):643-9. doi: 10.1245/s10434-013-3313-y. Epub 2013 Oct 12.
  4. Sinnamon AJ, Sonnenberg EM, Bartlett EK, Meise CK, Wang GJ, Kelz RR. The influence of socioeconomic factors on gender disparities in lower extremity bypass. J Surg Res. 2014 May 15;188(2):537-44. doi: 10.1016/j.jss.2014.01.043. Epub 2014 Jan 30.
  5. Ma P, Foote DC, Sinnamon AJ, Brass LF. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). PLoS One. 2015 Mar 18;10(3):e0119496. doi: 10.1371/journal.pone.0119496. eCollection 2015
  6. Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF. Modulating platelet reactivity through control of RGS18 availability. Blood. 2015 Dec 10;126(24):2611-20. doi: 10.1182/blood-2015-04-640037. Epub 2015 Sep 25.
  7. Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Fraker DL, Levin WP, Roses RE, Karakousis GK. Preoperative radiotherapy in the management of retroperitoneal liposarcoma. Br J Surg (in press)
  8. Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC. A prognostic model for resectable soft tissue and cutaneous angiosarcoma. J Surg Oncol. 2016 Jul 4. doi: 10.1002/jso.24352
  1. Sinnamon AJ, Ma P, Brass LF. Poster presentation: “Agonist-induced binding of the regulatory scaffold protein spinophilin to protein phosphatase-1 in platelets”. 2010 American Society of Hematology Annual Meeting, Orlando, FL, Nov 2010.                                  
  2. Bartlett EK, Sinnamon AJ, Wachtel H, Elder DE, Xu X, Schuchter LM, Ming ME, Gimotty P, Roses R, Czerniecki BJ, Kelz RR, Fraker DL, Karakousis GC. Sentinel Lymph Node Biopsy in Patients with Very Thin (<.76mm) Melanomas. Academic Surgical Congress 2013. 2012 Aug
  3. Bartlett EK, Gimotty P,  Sinnamon AJ, Wachtel H, Roses R, Schuchter LM, Xu X, Elder DE, Ming ME, Guerry D, Kelz RR, MD, Czerniecki BJ, Fraker DL, Karakousis GC. Sentinel Lymph Node Biopsy in Patients with Thin (≤1 mm) Melanoma. Society of Surgical Oncology 2013. 2012 Sep

Book Chapters

  1. Sinnamon, AJ and Kucharczuk, JC. The Esophagus. In The Surgical Review, 4th Ed

Dr. Andrew Sinnamon

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