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Heather Wachtel, M.D.
General Surgery Resident

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

heather.wachtel@uphs.upenn.edu

 

Dr. Wachtel is currently a sixth year General Surgery Resident.  She plans to pursue a career in Endocrine Surgery.  She recently completed two years of research in the laboratory of Dr. Douglas Fraker where her research projects included intraoperative imaging techniques for endocrine surgery, the impact of preoperative imaging on parathyroidectomy, the evaluation of long-term outcomes after adrenalectomy for aldosteronoma, and the role of adrenal vein sampling in the evaluation of patients prior to adrenalectomy

 
Appointments
2009 - present Assistant Instructor in Surgery
 
2012 - 2014 Postdoctoral Researcher, Laboratory of Dr. Douglas Fraker
 
 
 
 
 
 
 
 
Education/Training
2005 - 2009 MD - Yale University School of Medicine
New Haven, Connecticut
 
1999 - 2003 BA in History and Science - Harvard University
Cambridge Massachusetts
 
 
 
 
 
 
Memberships/Societies
  • American College of Surgeons
  • American Medical Association
  • American Association of Endocrine Surgeons
  • Association for Academic Surgeons
 
 
 
 
 
Research
07/2012 – 06/2014
Hospital of the University of PA, Philadelphia, Pennsylvania
Postdoctoral Research Fellow, Douglas Fraker, MD
Research in the laboratory of Douglas Fraker, Chief of the Division of Endocrine and Oncologic Surgery, Vice-Chairman of Research, and Jonathan E. Rhoads Professor of Surgical Science, Perelman School of Medicine.  Clinical and translational research on endocrine surgical topics including thyroid cancer, hyperparathyroidism, aldosteronoma, and pheochromocytoma.
 
05/2006 – 05/2009
Yale University School of Medicine, New Haven, Connecticut
MD student researcher, Jack Elias, MD
Thesis research in the laboratory of Jack Elias, Chairman, Department of Internal Medicine and Waldemar Von Zedtwitz Professor of Medicine at Yale School of Medicine. Independent basic science research on mechanisms of innate immune reactions and role of genetic polymorphisms in human acidic mammalian chitinase (AMCase) in Th2-cell mediated inflammatory asthma.
 
08/2003 - 08/2005
Massachusetts General Hospital, Dept. of GI, Boston, Massachusetts
Student researcher, Ramnik Xavier, MD
Research in the laboratory of Ramnik Xavier, Assoc. Professor of Medicine at Harvard Medical School. Conducted independent and guided research on signal transduction in immunological pathways. Utilized molecular techniques to explore the role of signaling molecules in T cell activation and differentiation.
 
09/2002 - 06/2003
Harvard University, Dept. of Biology, Cambridge, Massachusetts
Research assistant, Elena Kramer, PhD
Research in the laboratory of Elena Kramer, Asst. Professor of Biology at Harvard University. Conducted laboratory-based research on systematics and genetic mechanisms of floral development. Performed genetic and sequencing analyses of gene divergence in floral lineages.
 
06/2002 - 08/2002
Centers for Disease Control and Prevention, Atlanta, Georgia
Student researcher, Martin Cetron, MD
Epidemiological research on the incidence of domestic malaria, developing preventative recommendations for refugees, immigrants, and travelers. Epidemiological fieldwork on the effectiveness of medical screening and parasitic chemoprophylaxis in a refugee population.
 
06/2000 - 08/2000
Harvard School of Public Health, Boston, Massachusetts
Research assistant, Megan Murray, MD PhD
Research assistant to Megan Murray, MD, PhD, Assoc. Professor of Epidemiology at Harvard School of Public Health.
Compiled reports and articles on epidemiology of infectious disease. Worked with data input for computer modeling of the development of tuberculosis clusters in closed environments.
 

05/2000 - 06/2003
Harvard University, Dept. of History of Science, Cambridge, Massachusetts
Research assistant, I. Bernard Cohen, PhD
Research assistant to I. Bernard Cohen, Victor S. Thomas Professor of the History of Science, Emeritus. Performed
literature-based research and compiled reports on the introduction of numbers, statistics and quantity in 19th century thought.

 
Publications
 
Papers
  1. Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Karakousis GC, Fraker DL. “What can we learn from intraoperative parathyroid hormone levels which do not drop appropriately?” Ann Surg Oncol.  In press.
  2. Wachtel H, Jackson BM, Bartlett EK, Karakousis GC, Roses RE, Bavaria JE, Fraker DL.  “Resection of primary leiomyosarcoma of the inferior vena cava (IVC) with reconstruction: A case series and review of the literature.”  J Surg Onc.  In press.
  3. Wachtel H, Bartlett EK, Kelz RR, Cerullo I, Karakousis GC, Fraker DL.  “Primary hyperparathyroidism with negative imaging: A significant clinical problem.”  Ann Surg.  2014 Sep;260(3):474-80; discussion 480-2.
  4. Wachtel H, Cerullo I, Bartlett EK, Roses RE, Cohen DL, Kelz RR, Karakousis GC, Fraker DL.  “Clinicopathologic characteristics of incidentally identified pheochromocytoma.”  Ann Surg Oncol. 2014 Jul 22. 
  5. Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL.  “Long-term blood pressure control in patients undergoing adrenalectomy for primary hyperaldosteronism.” Surgery. In press.
  6. Bartlett EK, Wachtel H, Fraker DL, Vollmer CM, Drebin JA, Kelz RR, Karakousis GC, Roses RE.  “Surgical palliation for pancreatic malignancy: practice patterns and predictors of morbidity and mortality.”  J Gastrointest Surg. 2014 Mar 27.
  7. Kuo LE, Wachtel H, Fraker DL, Kelz RR.  “Reoperative parathyroidectomy: who is at risk and what is the risk?”  J Surg Res. 2014 Jun 2.
  8. Kuo LE, Wachtel H, Karakousis GC, Fraker DL, Kelz RR.  “Parathyroidectomy in dialysis patients.”  J Surg Res. 2014 Aug; 190(2): 554-8.
  9. Bartlett EK, Gimotty PA, Sinnamon AJ, Wachtel H, Roses RE, Schuchter L, Xu X, Elder DE, Ming M, Elenitsas R, Guerry D, Kelz RR, Czerniecki BJ, Fraker DL, Karakousis GC.  “Clark level risk stratifies patients with mitogenic thin melanomas for sentinel lymph node biopsy.” Ann Surg Oncol. 2014 Feb;21(2):643-9
  10. Ullery BW, Wachtel H, Raper SE. “Sister Mary Joseph’s nodule presenting as a large bowel obstruction: a case report and brief review of the literature.” J Gastrointest Surg. 2013 Oct: 17(10):1832-5.
  11. Bartlett EK, Roses RE, Gupta M, Shah PK, Shah KK, Zaheer S, Wachtel H, Kelz RR, Karakousis GC, Fraker DL.  “Surgery for metastatic neuroendocrine tumors with occult primaries.” J Surg Res. 2013 Sep;184(1):221-7
  12. Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.  “Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.”  Proc Natl Acad Sci. 2007 Sep 25;104(39):15424-9.
  13. Giallourakis C, Cao Z, Green T  Wachtel H, Xiaohui Xie, Lopez-Illasaca M, Daly M, Rioux J, Xavier R. “A Molecular Properties Based Approach to Understanding PDZ Domain Proteins and PDZ Ligands.” Genome Res. 2006 Jul 6.
  14. Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ.  “Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-κB activation.”  Mol Cell Biol. 2006 Jul;26(14):5497-508.
  15. Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B.  “Discs large (Dlg1) complexes in lymphocyte activation.” J Cell Biol. 2004 Jul 19;166(2):173-8.
Abstracts
  1. Wachtel H, Cerullo I, Bartlett EK, Fishbein L, Roses RE, Fraker DL, Cohen DL.  “Preoperative metyrosine improves outcomes for pheochromocytoma and paraganglioma resection.” Abstract to be presented at the North American Neuroendocrine Tumor Meeting, October 2014.
  2. Wachtel H, Ganguli A, Bonita B, Riff B, Fraker DL, Cohen DL.  “Long-term effects of surgical resection of pheochromocytoma or paraganglioma on body weight.”  Abstract presented at the International Symposium on Pheochromocytoma and Paraganglioma, September 2014.
  3. Wachtel H, Cerullo I, Bartlett EK, Fishbein L, Roses RE, Fraker DL, Cohen DL.  “Preoperative metyrosine improves outcomes for pheochromocytoma and paraganglioma resection.” Abstract presented at the International Symposium on Pheochromocytoma and Paraganglioma, September 2014.
  4. Wachtel H, Cerullo I, Bartlett EK, Kelz RR, Cohen DL, Karakousis GC, Roses RE, Fraker DL.  “Long term outcomes after adrenalectomy for primary hyperaldosteronism.” Abstract presented at American Association of Endocrine Surgeons meeting, April 2014.
  5. Wachtel H, Cerullo I, Bartlett EK, Roses RE, Cohen DL, Kelz RR, Karakousis GC, Fraker DL.  “Clinicopathologic characteristics of incidentally identified pheochromocytoma.”  Poster presented at American Association of Endocrine Surgeons meeting, April 2014.
  6. Wachtel H, Bartlett EK, Kelz RR, Cerullo I, Karakousis GC, Fraker DL. “Primary hyperparathyroidism with negative imaging: a significant clinical problem.”  Abstract presented at the American Surgical Association meeting, April 2014.
  7. Wachtel H, Cerullo I, Farquhar D, Bartlett EK, Kelz RR, Karakousis GC, Fraker DL.  “What can we learn from failed parathyroid operations?”  Abstract presented at Society of Surgical Oncology meeting March 2014.
  8. Wachtel H, Gupta M, Bartlett EK, Kelz RR, Cerullo I, Karakousis GC, Fraker DL.  “Early onset primary hyperparathyroidism: what are the clinical implications?”  Abstract presented at American Surgical Congress meeting February 2014.
  9. Wachtel H, Ullery BW, Raper SE.  “Sister Mary Joseph’s Nodule Presenting as Large Bowel Obstruction.”  Case presented as a “Spectacular Case” at the American College of Surgeons Surgical Forum, October 2013.
  10. Wachtel H, Wismer MC, Bartlett EK, Kelz RR, Karakousis GC, Fraker DL.  “What can we learn from failed parathyroid operations?”  Abstract accepted as one of six finalists in the Resident Abstract Contest, presented at the Philadelphia Academy of Surgery meeting February 2013. 
  11. Wachtel H, Wismer MC, Bartlett EK, Shah PK, Kelz RR, Karakousis GC, Fraker DL.  “Minimally Invasive Parathyroidectomy is the Best Initial Operation for Patients with Localized Parathyroid Disease.”  Abstract presented at Society of Surgical Oncology meeting March 2013.
  12. Bartlett EK, Gimotty P, Sinnamon A, Wachtel H, Schuchter LM, Ming ME, Elenitsas R, Xu S, Elder DE, Kelz RR, Roses RE, Czerniecki BJ, Fraker DL, Karakousis GC.  “Sentinel Lymph Node (SLN) Biopsy in Patients with Thin (≤1 mm) Melanoma.” Abstract presented at Society of Surgical Oncology meeting March 2013.
  13. Webb CM, Wachtel H, Bartlett EK, Kelz RR, Karakousis GC, Fraker DL.  “Predictors of Patient Response to Isolated Limb Perfusion for Metastatic Melanoma.”  Abstract presented at Society of Surgical Oncology meeting March 2013.
  14. Wachtel H, Wismer MC, Bartlett EK, Shah PK, Shah KK, Kelz RR, Karakousis GC, Fraker DL.  “Negative Imaging Is Not A Contraindication To Surgical Parathyroidectomy.”  Abstract presented at American Surgical Congress meeting February 2013.
  15. Webb CM, Wachtel H, Bartlett EK, Shah PK, Shah KK, Kelz RR, Karakousis GC, Fraker DL.  “Intraoperative PTH Monitoring Criteria In Secondary Hyperparathyroidism.”  Abstract presented at American Surgical Congress meeting February 2013.
  16. Bartlett EK, Sinnamon AJ, Wachtel H, Elder DE, Xu X, Schuchter LM, Ming ME, Gimotty P, Roses R, Czerniecki BJ, Kelz RR, Fraker DL, Karakousis GC.  “Sentinel Lymph Node Biopsy In Patients With Very Thin (<.76mm) Melanomas.”  Abstract presented at American Surgical Congress meeting February 2013.
  17. He CH, Lee CG, Wachtel H, Hartl D, Chen NY, Homer RJ, and Elias JA.  “Acidic Mammalian Chitinase Binds to the Epidermal Growth Factor Receptor which Regulates AMCase Production and Secretion.”  Abstract presented at American Thoracic Society, May 2008.
 
Awards
2014 Best Clinical Research Presentation, American Association of Endocrine Surgeons
 
 
 
 
 
 
 
 
 
 

Dr. Heather Wachtel

 
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