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Heather Wachtel, M.D.
General Surgery Resident

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Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

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Dr. Wachtel is currently a fifth year General Surgery Resident.  She plans to pursue a career in Surgical Oncology with a focus on Endocrine Surgery.  She is currently in her second year of research in the laboratory of Dr. Douglas Fraker.  Her research projects include intraoperative imaging techniques for endocrine surgery, genetic profiling of metastatic thyroid cancer, and the evaluation of adrenal-sparing resection for adrenal adenoma.

2009 - present Assistant Instructor in Surgery
2012 - present Postdoctoral Researcher
2005 - 2009 MD - Yale University School of Medicine
New Haven, Connecticut
1999 - 2003 BA in History and Science - Harvard University
Cambridge Massachusetts
  • American College of Surgeons
  • American Medical Association

05/2006 – 05/2009
Yale University School of Medicine, New Haven, CT
MD student researcher, Jack Elias, MD
Thesis research in the laboratory of Jack Elias, Chairman, Department of Internal Medicine and Waldemar Von Zedtwitz Professor of Medicine at Yale School of Medicine. Independent basic science research on mechanisms of innate immune reactions and role of genetic polymorphisms in human acidic mammalian chitinase (AMCase) in Th2-cell mediated inflammatory asthma.

08/2003 - 08/2005
Massachusetts General Hospital, Dept. of GI, Boston, MA
Student researcher, Ramnik Xavier, MD
Research in the laboratory of Ramnik Xavier, Assoc. Professor of Medicine at Harvard Medical School. Conducted independent and guided research on signal transduction in immunological pathways. Utilized molecular techniques to explore the role of signaling molecules in T cell activation and differentiation.

09/2002 - 06/2003
Harvard University, Dept. of Biology, Cambridge, MA
Research assistant, Elena Kramer, PhD
Research in the laboratory of Elena Kramer, Asst. Professor of Biology at Harvard University. Conducted laboratory-based research on systematics and genetic mechanisms of floral development. Performed genetic and sequencing analyses of gene divergence in floral lineages.

06/2002 - 08/2002
Centers for Disease Control and Prevention, Atlanta, GA
Student researcher, Martin Cetron, MD
Epidemiological research on the incidence of domestic malaria, developing preventative recommendations for refugees, immigrants, and travelers. Epidemiological fieldwork on the effectiveness of medical screening and parasitic chemoprophylaxis in a refugee population.

06/2000 - 08/2000
Harvard School of Public Health, Boston, MA
Research assistant, Megan Murray, MD PhD
Research assistant to Megan Murray, MD, PhD, Assoc. Professor of Epidemiology at Harvard School of Public Health.
Compiled reports and articles on epidemiology of infectious disease. Worked with data input for computer modeling of the development of tuberculosis clusters in closed environments.

05/2000 - 06/2003
Harvard University, Dept. of History of Science, Cambridge, MA
Research assistant, I. Bernard Cohen, PhD
Research assistant to I. Bernard Cohen, Victor S. Thomas Professor of the History of Science, Emeritus. Performed
literature-based research and compiled reports on the introduction of numbers, statistics and quantity in 19th century thought.

  1. Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci USA.2007 Sep;
    104(39): 15424-9. Cited in PubMed; PMID: 17878299.
  2. Giallourakis C, Cao Z, Green T, Wachtel H, Xiaohui Xie, Lopez-Illasaca M, Daly M, Rioux J, Xavier R. A Molecular Properties Based Approach to Understanding PDZ Domain Proteins and PDZ Ligands. Genome Res.2006 Aug; 16(8): 1056-72. Cited in
    PubMed; PMID: 16825666.
  3. He CH, Lee CG, Wachtel H, Hartl D, Chen NY, Homer RJ, Elias JA. Acidic Mammalian Chitinase (AMCase) Binds to the Epidermal Growth Factor Receptor (EGFR) Which Regulates AMCase Production and Secretion. American Journal of
    Respiratory and Critical Care Medicine.2008 Apr; 177(Abstracts Issue): A502.
  4. Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ. Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-κB activation. Mol Cell Biol.2006
    Jul; 26(14): 5497-508. Cited in PubMed; PMID: 16809782.
  5. Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B. Discs large (Dlg1) complexes in lymphocyte

Dr. Heather Wachtel

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