Carlo Bartoli, MD, PhD - Cardiovascular Surgery

Dr. Bartoli attended Cornell University, Harvard University, and the University of Louisville School of Medicine.  He completed integrated cardiac surgery training at the Hospital of the University of Pennsylvania, where he is appointed as an Instructor of Surgery in the Division of Cardiovascular Surgery.  Currently, he is doing an additional year of fellowship in pediatric cardiothoracic surgery at the Children’s Hospital of Philadelphia.  Dr. Bartoli has won numerous national and international scientific awards for his investigations in cardiovascular medicine.  He sits on the Board of Directors for the International Society of Mechanical Circulatory Support and Medical Advisory Boards for Abiomed Inc, Evaheart International Inc, and Windmill Cardiovascular Systems Inc.  His interests are surgical management of acquired and congenital heart disease, development and clinical implantation of mechanical circulatory support devices, von Willebrand factor biology, and angiogenesis.

In parallel with clinical training, Dr. Bartoli has established a translational biophysics laboratory with investigations at the University of Pennsylvania and Children’s Hospital of Philadelphia as well as multiple national and international collaborations. The laboratory is independently funded with support from the NIH, multiple congenital cardiology foundations, and industry partners.

Ongoing projects examine mechanical circulatory support in the fetus to the adult and include left ventricular assist device (LVAD) design and development, mechanisms of LVAD-associated bleeding and thrombosis, novel LVAD therapies, abnormal angiogenesis in children with single ventricle disease, and cardiovascular biology of the placenta.  Advancing the field of cardiovascular medicine and training MD/PhD physician-scientists are major goals of the laboratory.

Peer-Reviewed Publications

  1. BARTOLI CR, Dowling RD. Next-generation mechanical circulatory support devices for the management of advanced heart failure. Cardiac Interventions Today. 2019, 13(1).
  2. BARTOLI CR, Hennessy-Strahs S, Gohean J, Villeda M, Larson E, Longoria R, Kurusz M, Acker MA, Smalling R. The TORVAD, a novel toroidal-flow LVAD minimizes blood trauma versus the HeartMate II: Implications of improved LVAD hemocompatibility. Annals of Thoracic Surgery. 2019, 107(6): 1761-1767.
  3. Lawrence KM, Hennessy-Strahs S, McGovern PE, Mejaddam AY, Rossidis AC, Baumgarten HD, Bansal E, Villeda M, Rychik J, Peramteau WH, Davey MG, Flake AW, JW Gaynor, BARTOLI CR.  Normoxic but not hypoxic extracorporeal support of the fetus in an artificial womb allows normal cardiac development. Journal of Clinical Investigation - Insight. 2018, 3(24).
  4. BARTOLI CR, Zhang D, Hennessy-Strahs S, Kang J, Restle D, Atluri P, Acker MA. Clinical and in vitro evidence that LVAD-induced von Willebrand factor degradation alters angiogenesis. Circulation: Heart Failure. 2018, 11(9).
  5. BARTOLI CR, Zhang D, Kang J, Hennessy-Strahs S, Restle D, Howard J, Redline G, Bermudez C, Atluri P, Acker MA. Clinical and ex vivo evidence that subclinical LVAD-associated hemolysis contributes to LVAD thrombosis. Annals of Thoracic Surgery. 2018, 105(3): 807-814.
  6. Kang J, Hennessy-Strahs S, Kwiatkowski P, Bermudez CA, Acker MA, Atluri P, McConnell PI, BARTOLI CR. Continuous-flow LVAD support causes a distinct form of intestinal angiodysplasia. Circulation Research. 2017, 121(8): 963-969.
  7. Flaherty MP, Pant S, Kilgore T, Dassanayaka S, Loughran JH, Rawasia W, Buddhadeb D, BARTOLI CR.  Impella 2.5 support protects against acute kidney injury in patients undergoing high-risk percutaneous coronary intervention. Circulation Research. 2017, 120(4): 692-700.
  8. BARTOLI CR, Soucy K, Philips D, Giridharan G, Sobieski MA, Wead W, Dowling RD, Zhongjun JW, Prabhu S, Slaughter MS, Koenig SC. Continuous-flow left ventricular assist device support improves myocardial supply:demand in chronic heart failure. Annals of Biomedical Engineering. 2017, 45(6): 1475-1486.
  9. BARTOLI CR, Kang, J, Zhang D, Howard J, Acker MA, Atluri P, Motomura T. LVAD design reduces von Willebrand factor degradation: a comparative study between the HeartMate II and the EVAHEART left ventricular assist system. Annals of Thoracic Surgery. 2017, 103(4): 1239-1244.
  10. Flaherty MP, Pant S, Kilgore T, Dassanayaka S, Loughran JH, Rawasia W, Buddhadeb D, BARTOLI CR.  Impella 2.5 support protects against acute kidney injury in patients undergoing high-risk percutaneous coronary intervention. Journal of the American College of Cardiology. 2016, 1;68(18S):B49-B50.
  11. BARTOLI CR. Antibody-based protection of von Willebrand factor degradation. Journal of the American College of Cardiology: Heart Failure. 2016, 4(6): 518-519.
  12. Kang J, Zhang D, Restle D, Kallel F, Acker MA, Atluri P, BARTOLI CR. Reduced continuous-flow LVAD speed does not decrease von Willebrand factor degradation. Journal of Thoracic and Cardiovascular Surgery. 2016, 151(6): 1747-1754.
  13. BARTOLI CR, Kang J, Restle DJ, Zhang DM, Shabahang C, Acker MA, Atluri P. Inhibition of ADAMTS-13 by doxycycline reduces von Willebrand factor degradation during supraphysiologic shear stress: therapeutic implications for LVAD-associated bleeding. Journal of the American College of Cardiology: Heart Failure. 2015, 3(11): 860-869.
  14. BARTOLI CR, Atluri P. Do continuous-flow LVAD patients benefit from induced-pulsatility or are we just spinning our wheels? Journal of Thoracic and Cardiovascular Surgery. 2015, 150(4): 945-946.
  15. BARTOLI CR, Restle DJ, Zhang DM, Acker MA, Atluri P. von Willebrand factor degradation with an LVAD occurs via two distinct mechanisms: Mechanical demolition and enzymatic cleavage. Journal of Thoracic and Cardiovascular Surgery. 2015, 149(1): 281-289.
  16. Giridharan GA, Koenig SC, Soucy KG, Young C, Pirbodaghi T, BARTOLI CR, Monreal G, Sobieski MA, Schumer E, Cheng A, Slaughter MS. Left ventricular volume unloading with axial and centrifugal rotary blood pumps. ASAIO J. 2015, 61(3): 292-300.
  17. Giridharan GA, Koenig SC, Soucy KG, Young C, Pirbodaghi T, BARTOLI CR, Monreal G, Sobieski MA, Schumer E, Cheng A, Slaughter MS. Hemodynamic changes and retrograde blood flow in LVAD patients. ASAIO J. 2015, 61(3): 282-291.
  18. Restle DJ, Zhang DM, Hung G, Howard JL, Kallel F, Acker MA, Atluri P, BARTOLI CR. Preclinical models for translational investigations of LVAD-associated von Willebrand factor degradation. Artificial Organs. 2015, 39(7): 569-575.
  19. Flaherty MP, Mohsen A, Moore JB, BARTOLI CR, Schneibel E, Rawasia W, Williams ML, Grubb K, Hirsch GA.  Predictors and clinical impact of preexisting and acquired thrombocytopenia following transcatheter aortic valve replacement. Catheterization and Cardiovascular Interventions. 2015, 85(1): 118-129.
  20. BARTOLI CR, Ghotra AS, Pachika AR, Birks EJ, McCants KC. Hematologic Markers Better Predict LVAD Thrombosis Than Echocardiographic or Pump Parameters. The Thoracic and Cardiovascular Surgeon. 2014, 148(1): 311-321.
  21. BARTOLI CR, Spence PA, Siess T, Raess DH, Koenig SC, Dowling RD. Nonphysiologic blood flow triggers endothelial and arterial remodeling in vivo: Implications for LVADs with a peripheral anastomosis. Journal of Thoracic and Cardiovascular Surgery. 2014, 148(1): 311-321.
  22. BARTOLI CR, Rogers BD, Ionan CE, Koenig SC, Pantalos GM. End-diastolic flow reversal may limit the efficacy of pediatric intraaortic balloon counterpulsation. Journal of Thoracic and Cardiovascular Surgery. 2014, 147(5):1660-1667.
  23. BARTOLI CR, Dassanayaka S, Brittian KR, Luckett A, Sithu S, Siess T, Raess DH, Spence PA, Koenig SC, Dowling RD, D’Souza SE. Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support. Journal of Thoracic and Cardiovascular Surgery. 2014, 147(5): 1634-1643.
  24. BARTOLI CR, Ailawadi G, Kern JA. Diagnosis, non-surgical management, and prevention of LVAD thrombosis. Journal of Cardiac Surgery. 2014, 29(1): 83-94.
  25. BARTOLI CR, Sherwood LC, Giridharan GA, Slaughter MS, Wead WB, Prabhu SD, Koenig SC. Bovine model of chronic ischemic cardiomyopathy: Implications for ventricular assist device research. Artificial Organs. 2013, 37(12): E202-214.
  26. BARTOLI CR, Koenig SC, Ionan C, Gillars KJ, Mitchell ME, Austin EH, Gray LA, Pantalos GM.  Extracorporeal membrane oxygenation vs. counterpulsatile, pulsatile, and continuous blood flow for pediatric mechanical circulatory support. Pediatric Critical Care Medicine. 2013, 14(9):e424-37.
  27. BARTOLI CR, Demarest CT, Khalpey Z, Takayama H, Naka Y.  Current management of left ventricular assist device erosion. Journal of Cardiac Surgery. 2013, 28(6):776-82.
  28. BARTOLI CR, Vessels KM, McCants KC. Increased intrathoracic impedance predicts adverse events in LVAD patients.  Journal of Cardiac Surgery, 2013, 28(5): 616-618.
  29. BARTOLI CR, McCants KC, Birks EJ, Flaherty MP, Slaughter MS. Percutaneous closure of a patent foramen ovale to prevent paradoxical thromboembolism in a patient with a continuous-flow LVAD: Case report and literature review. Journal of Invasive Cardiology. 2013, 25(13): 154-156. 
  30. Dassanayaka S, Slaughter MS, BARTOLI CR. Mechanistic pathway(s) of acquired von Willebrand syndrome with a continuous-flow ventricular assist device: in vitro findings. ASAIO J. 2013, 59(2): 123-129. 
  31. BARTOLI CR, Wead WB, Giridharan GA, Prabhu SD, Koenig SC. What is the culprit in coronary anomalies? Reply. Journal of Thoracic and Cardiovascular Surgery. 2012, 144(6): 1531-1533. 
  32. BARTOLI CR, Wead WB, Giridharan GA, Prabhu SD, Koenig SC, Dowling RD. Mechanism of myocardial ischemia with an anomalous left coronary artery from the right sinus of Valsalva. Journal of Thoracic and Cardiovascular Surgery. 2012, 144(2):402-408.
  33. Giridharan GA, BARTOLI CR, Spence PA, Dowling RD, Koenig SC. A novel counterpulsation device provides flow augmentation compared to intra-aortic balloon counterpulsation. Artificial Organs. 2012, 36(7):600-606.
  34. BARTOLI CR, Dassanayaka S, Brittian KR, Nadar AC, Ismahil MA, Koenig SC, Prabhu SD. A microsphere-based technique for the direct measurement of blood flow in microvessels grown in Matrigel in vivo. Journal of Surgical Research. 2012, 172(1):e55-60.
  35. Warren S, Giridharan GA, Dowling RD, Spence PA, Tompkins L, Gratz E, Sherwood LC, Sobieski MA, BARTOLI CR, Slaughter MS, Keynton RS, Koenig SC. Feasibility of subcutaneous ECG leads for synchronized timing of a counterpulsation device. Cardiovascular Engineering and Technology. 2012, 3(1): 17-25.
  36. BARTOLI CR, Dowling RD. The future of adult cardiac assist devices: Novel systems and mechanical circulatory support strategies. Cardiology Clinics. 2011, 29(4):559-582.
  37. BARTOLI CR, Nadar MM, Loyd GE, Kasdan ML. An atypical case of anesthesia-induced reverse Takotsubo cardiomyopathy in a 30-year-old male with post-traumatic stress disorder.  Journal of Cardiothoracic and Vascular Anesthesia. 2011, 25(6):1116-1118. 
  38. BARTOLI CR, Brittian KR, Giridharan GA, Koenig SC, Hamid T, Prabhu SD. Bovine model of doxorubicin-induced chronic heart failure. Journal of Biomedicine and Biotechnology. 2011, 2011:758736.
  39. BARTOLI CR, Dowling RD, Wilson GC, Giridharan GA, Slaughter MS, Sherwood LC, Spence PA, Prabhu SD, Koenig SC. A novel subcutaneous counterpulsation device: Acute hemodynamic responses to pharmacologically-induced hypertension, hypotension, and heart failure. Response to Letter to the Editor.  Artificial Organs. 2011, 35(1):93-5.
  40. BARTOLI CR, Godleski JJ, Verrier RL. Mechanisms mediating adverse effects of air pollution on cardiovascular  hemodynamic function and vulnerability to cardiac arrhythmias. Air Quality, Atmosphere, and Health. 2011,
    4:53-63.
  41. BARTOLI CR, Nadar MM, Godleski JJ. Capsule thickness correlates with vascular density and blood flow within foreign-body capsules surrounding surgically implanted subcutaneous devices. Artificial Organs. 2010, 34(10);857-861.
  42. Nadar MM, BARTOLI CR, Kasdan ML. Lipomas of the hand: a review and 13 patient case series. ePlasty, 2010, 10(25):e66.
  43. BARTOLI CR, Wilson GC, Giridharan GA, Slaughter MS, Sherwood LC, Spence PA, Prabhu SD, Koenig SC. A novel subcutaneous counterpulsation device: Acute hemodynamic responses to pharmacologically-induced hypertension, hypotension, and heart failure. Artificial Organs. 2010, 34(7):537-45.
  44. BARTOLI CR, Giridharan GA, Litwak KN, Sobieski MA, Prabhu SD, Slaughter MS, Koenig SC. Hemodynamic responses to continuous versus pulsatile unloading of the failing left ventricle. ASAIO J. 2010, 56(5):410-6.
  45. Slaughter MS, Ising MS, Tamez D, O'Driscoll G, Voskoboynikov N, BARTOLI CR, Koenig SC, Giridharan GA. Increase in circadian variation of flow after continuous flow ventricular assist device implantation. Journal of Heart and Lung Transplantation. 2010, 29(6):695-7.
  46. BARTOLI CR, Godleski JJ. Blood flow in the foreign-body capsule surrounding surgically implanted subcutaneous devices. Journal of Surgical Research. 2010, 158(1): 147-154.
  47. BARTOLI CR, Wellenius GA, Coull BA, Diaz EA, Lawrence J, Akiyama I, Okabe K, Verrier RL, Godleski JJ. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environmental Health Perspectives. 2009, 117(3): 333-337.
  48. BARTOLI CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Katz T, Okabe K, Verrier RL, Godleski JJ. Acute mechanisms of particulate air pollution-induced arterial blood pressure changes. Environmental Health Perspectives. 2009, 117(3): 361-366.
  49. Slaughter MS, BARTOLI CR, Sobieski MA, Pantalos GM, Giridharan GA, Dowling RD, Prabhu SD, Farrar DJ, Koenig SC. Intraoperative evaluation of the HeartMate II flow estimator. Journal of Heart and Lung Transplantation. 2009, 28(1):39-43.
  50. BARTOLI CR, Okabe K, Akiyama I, Godleski JJ. Repeat microsphere delivery for serial measurement of regional blood perfusion in the chronically instrumented, conscious canine.  Journal of Surgical Research. 2008, 145(1):135-41.
  51. BARTOLI CR, Akiyama I, Okabe K, Diaz EA, Godleski JJ. Permanent tracheostomy for long-term respiratory studies. Journal of Surgical Research. 2008, 145(1):124-9.
  52. Gelzer AR, Koller ML, Otani NF, Fox JJ, Enyeart MW, Hooker GJ, Riccio ML, BARTOLI CR, Gilmour RF. Dynamic mechanism for initiation of ventricular fibrillation in vivo. Circulation. 2008, 9;118(11):1123-9.
  53. Kumar K, Nearing BD, BARTOLI CR, Kwaku KF, Belardinelli L, Verrier RL.  Effect of Ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. Journal of Cardiovascular Electrophysiology. 2008, 19(10):1073-9.
  54. BARTOLI CR, Akiyama I, Godleski JJ, Verrier RL. Long-term pericardial catheterization is associated with minimum foreign body response. Catheterization and Cardiovascular Interventions. 2007, 70(2):221-227.
  55. BARTOLI CR, Okabe K, Akiyama I, Verrier RL, Godleski JJ. Technique for implantation of chronic indwelling aortic access catheters.  Journal of Investigative Surgery. 2006, 19(6): 397-405.
  56. BARTOLI CR, Nadar, AC, Koenig SC, Prabhu SD. Altered vasa vasorum blood flow and arterial remodeling in chronic ischemic heart failure. Submitted, Under Review.
  57. Hennessy-Strahs S, Kang J, Krause E, Jegatheeswaran A, Bermudez C, Atluri P, Acker MA, BARTOLI CR. Novel quantitative analysis of von Willebrand factor degredation and function predict the risk of LVAD-associated bleeding. Under Review.
  58. Motomura T, Tuzun E, Yamazaki K, Tatsumi E, Benkowski R, Sonntag S, Nestler F, May-Newman K, BARTOLI CR, Shiraishi Y, Yamazaki S. Preclinical evaluation of EVAHEART 2 Centrifugal LVAS. Under Review.
  59. Hennessy-Strahs S, Bermudez C, Atluri P, Acker MA, BARTOLI CR. Towards a standard practice for the quantification of von Willebrand factor degradation during mechanical circulatory support. Under Review.
  60. Hennessy-Strahs S, Kang J, Motomura T, BARTOLI CR. Decreased RPM reduces von Willebrand factor degradation with the EVAHEART LVAS: Implications for device-specific management. Under Review.
  61. BARTOLI CR, Hennessy-Strahs S, Dowling RD, Gaynor JW, Glatz AC. Mechanistic insight into abnormal angiogenesis in children with a Glenn circulation: the role of the von Willebrand-angiopoietin axis. Under review.

Invited Talks And Presented Abstracts

(* Award Winner, ‡Award Nomination,  †Oral Presentation, ¥Invited Oral Presentation)

  1. ¥BARTOLI CR. LVAD hemocompatibility: The human-machine interface. Proceedings of the                        American Society of Artificial Internal Organs, San Francisco, CA, June, 2019.
  2. ¥BARTOLI CR. Von willebrand factor degradation is a major unsolved problem in LVAD patients.                        Gordon Research Conference on Assisted Circulation, Barcelona, Spain, June, 2019.
  3. *†BARTOLI CR, Hennessy-Strahs S, Waldron A, Whitehead K, Gaynor JW, Glatz AC. Mechanistic insight into the role of the von Willebrand factor-angiopoietin axis in pulmonary arteriovenous malformations in children with a Glenn connection. Young Investigator Award Session. Proceedings of the American College of Cardiology, New Orleans, LA, March, 2019.
  4. ¥BARTOLI CR. Impact of Impella 2.5 support on acute kidney injury during high-risk percutaneous coronary interventions. American Heart Association Scientific Sessions, Chicago, IL, November, 2018.
  5. Vining C, Vela M, Sheridan E, BARTOLI CR, Khandahar S, Pascual J, Canon J. Percutaneous thrombectomy of large right atrial in-transit thrombus after major trauma. Proceedings of the Society of Critical Care Medicine, San Diego, CA, February, 2019.
  6. †BARTOLI CR, Lawrence K, McGovern P, Bansal E, Hennessy-Strahs S, Villeda M, Mejaddam A, Rossidis A, Baumgarten H, Rychik J, Gaynow JW, Davey M, Flake A. Fetal hypoxemia causes abnormal myocardial development in a preterm ex utero fetal ovine model: implications for adult cardiovascular disease and novel fetal therapy. Proceedings of the Society of Thoracic Surgeons: Latin America, Cartagena, Columbia, November, 2018.
  7. Hennessy-Strahs S, Atluri P, Bermudez C, Acker MA, BARTOLI CR. Elevated von Willebrand factor multimers are associated with LVAD thrombosis. Proceedings of the International Society of Mechanical Circulatory Support, Tokyo, Japan, October 2018.
  8. Hennessy-Strahs S, Atluri P, Bermudez C, Acker MA, BARTOLI CR. Continuous-flow LVAD support alters multiple angiogenic signaling peptides. Proceedings of the International Society of Mechanical Circulatory Support, Tokyo, Japan, October 2018.
  9. ¥BARTOLI CR. Subclinical hemolysis contributes to LVAD thrombosis. Proceedings of the                         American Society of Artificial Internal Organs, Washington DC, June, 2018.
  10. ¥BARTOLI CR. Veno-arterial and veno-venous ECMO insertion simulation.  Penn Medicine Adult                        ECMO Symposium, Philadelphia, PA, May, 2018.
  11. Siki MA, BARTOLI CR, Vernick WJ, Szeto WY. Redo aortic root replacement with homograft for aortic root abscess after previous AVR.  Proceedings of the Society of Thoracic Surgeons, Fort Lauderdale, Florida, January 2018.
  12. ¥BARTOLI CR. Ventricular assist device hemocompatibility: the machine-human interface. Hospital of The University of Pennsylvania, Department of Cardiovascular Medicine Grand Rounds. December, 2017.
  13. Hennessy-Strahs S, Bermudez C, Atluri P, Acker MA, BARTOLI CR. von Willebrand factor multimers, fragments, and function predict the risk of LVAD-associated bleeding. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  14. Hennessy-Strahs S, Sakatsume K, Bermudez C, Atluri P, Acker MA, Horiuchi H, BARTOLI CR. Establishing a standard practice for the evaluation of von Willebrand factor multimer degradation in rotary blood pumps. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  15. †BARTOLI CR, Gohean J, Hennessy-Strahs S, Bansal E, Villeda M, Larson E, Longoria R, Kurusz M, Acker MA, Smalling R. A novel toridal-flow LVAD demonstrates significantly improved hemocompatibility versus the HeartMate II: Implications for the design of next-generation LVADs. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  16. ¥BARTOLI CR. Mechanisms of von Willebrand factor degradation and bleeding during artificial circulation. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  17. ‡†BARTOLI CR, Lawrence K, McGovern P, Bansal E, Hennessy-Strahs S, Villeda M, Mejaddam A, Rossidis A, Baumgarten H, Rychik J, Gaynow JW, Davey M, Flake A. Normoxic but not hypoxic extracorporeal circulatory support of the fetus in an artificial womb allows normal cardiac development. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  18. †BARTOLI CR, Hennessy-Strahs S, Kang J, Atluri P, Acker MA, Bermudez C. von Willebrand factor degradation fragments are a mechanistic link between continuous-flow LVAD support and gastrointestinal angiodysplasia and bleeding. Proceedings of the Society of Thoracic Surgeons: Latin America, Cartagena, Columbia, September, 2017.
  19. *†Lawrence K, McGovern P, BARTOLI CR, Mejaddam A, Rossidis A, Baumgarten H, Bansal E, Hennessy-Strahs S, Villeda M, Davey M, Flake A, Gaynor W. Chronic in utero hypoxia alters cardiovascular development in a fetal sheep model. Proceedings of the International Fetal Medicine and Surgery Society, Jackson Hole, WY, October, 2017.
  20. Larson E, Gohean J, Hennessy-Strahs S, BARTOLI CR, Smalling RW, Longoria RG. Initial bench top and animal testing with the pediatric TORVAD confirms low-shear pumping and synchronization. Proceedings of the International Society of Mechanical Circulatory Support, Tucson, AZ, October 2017.
  21. Gohean JR, Larson ER, Longoria RG, Kurusz M, Hennessy-Strahs S, BARTOLI CR, Smalling RW. Low shear and thromboresistance in the synchronous pulsatile adult and pediatric TORVAD. Proceedings of the American Society of Artificial Internal Organs, Chicago, IL, 2017.
  22. Hennessy-Strahs S, Bansal E, Kang J, Krause E, Acker M, Bermudez C, Atluri P, BARTOLI CR. Novel analysis of high-molecular-weight von Willebrand factor multimers predicts bleeding events. Proceedings of the International Society of Heart and Lung Transplantation, San Diego, CA, April, 2017.
  23. Hennessy-Strahs S, Zhang D, Kang J, Krause E, Redline G, Howard J, Acker M, Atluri P, Bermudez C, BARTOLI CR. Plasma free hemoglobin activates platelets and protects von Willebrand factor from degradation: Clinical and in vitro evidence that LVAD hemolysis causes LVAD thrombosis. Proceedings of the International Society of Heart and Lung Transplantation, San Diego, CA, April, 2017.
  24. ¥BARTOLI CR. Pathologic von Willebrand Factor degradation during artificial circulation: Consequences and novel management strategies. Platelet Club. University of Pennsylvania, December, 2016.
  25. *†BARTOLI CR, Zhang D, Kang J, Restle D, Kwiatkowski P, Bermudez C, Acker MA, Atluri P, McConnell P. LVAD-associated von Willebrand factor degradation fragments alter angiogenesis: A mechanistic link between LVAD support, gastrointestinal angiodysplasia, and bleeding? Young Investigator Award Session. Proceedings of the American College of Cardiology, Washington, D.C., March, 2017.
  26. ¥BARTOLI CR, Glatz A, Whitehead K, Rome J. Altered angiogenesis is patients with a cavopulmonary anastomosis. Frontier Single Ventricle Forum. Children’s Hospital of Philadelphia, Philadelphia, PA, November 2016.
  27. *†BARTOLI CR, Zhang D, Kang J, Restle D, Redline G, Howard J, Bermudez C, Acker MA, Atluri P. Clinical and in vitro evidence that LVAD-associated hemolysis contributes to LVAD thrombosis.  Proceedings of the Society of Thoracic Surgeons, Houston, TX January 2017.
  28. Flaherty MP, Pant S, Kilgore T, Dassanayaka S, Loughran JH, Rawasia W, Buddhadeb D, BARTOLI CR.  Impella 2.5 support protects against acute kidney injury in patients undergoing high-risk percutaneous coronary intervention. Proceedings of Transcatheter Cardiovascular Therapeutics, Washington, D.C., October, 2016.
  29. †BARTOLI CR, Kang J, Zhang D, Acker MA, Atluri P, Motomura T. Reduced LVAD speed decreases von Willebrand factor degradation with the Evaheart LVAS but not with the HeartMate II: Implications for clinical operation of continuous-flow LVADs.  Proceedings of the International Society of Rotary Blood Pumps, Mito, Japan, September 2016.
  30. †‡BARTOLI CR, Zhang D, Kang J, Restle D, Kwiatkowski P, Bermudez C, Acker MA, Atluri P, McConnell P. LVAD-associated von Willebrand factor degradation fragments are the mechanistic link between LVAD support and gastrointestinal angiodysplasia. Proceedings of the International Society of Rotary Blood Pumps, Mito, Japan, September 2016.
  31. Larson E, Gohean JR, Longoria G, Kurusz M, Smalling RW, Kang J, BARTOLI CR. Low shear TORVAD ventricular assist device preserves von Willebrand factor in chronic ovine model. Proceedings of the American Society of Artificial Internal Organs, San Francisco, CA, June 2016.
  32. Kang J, Zhang D, Motomura T, Acker MA, Atluri P, BARTOLI CR. LVAD device design features and operational settings minimize von Willebrand Factor degradation.  Proceedings of the International Society of Heart and Lung Transplantation, Washington, D.C., April 2016.
  33. Kang J, Kwiatkowski P, Acker MA, Atluri P, McConnell P, BARTOLI CR. Continuous-flow LVAD support alters gastrointestinal vascularity: A likely contributor to LVAD-associated gastrointestinal bleeding.  Proceedings of the International Society of Heart and Lung Transplantation, Washington, D.C., April 2016.
  34. Zhang D, Kang J, Redline G, Howard J, Acker M, Atluri P, BARTOLI CR. Elevated plasma free hemoglobin and hemin may predict LVAD thrombosis. Proceedings of the International Society of Heart and Lung Transplantation, Washington, D.C., April 2016.
  35. Zhang D, Kang J, Redline G, Howard J, Acker M, Atluri P, BARTOLI CR. LVAD support increases plasma iron species: Implications for a pathophysiologic relationship between LVAD-associated hemolysis and thrombosis. Proceedings of the International Society of Heart and Lung Transplantation, Washington, D.C., April 2016.
  36. Kang J, Zhang D, Motomura T, Acker MA, Atluri P, BARTOLI CR. Centrifugal-flow LVADs cause less von Willebrand factor degradation then axial-flow LVADs. Proceedings of the International Society of Rotary Blood Pumps, Dubrovnik, Croatia, September 2015.
  37. Kang J, Zhang D, Restle D, Kallel F, Acker MA, Atluri P, BARTOLI CR. Reduced continuous-flow LVAD speed does not decrease von Willebrand factor degradation. Proceedings of the International Society of Rotary Blood Pumps, Dubrovnik, Croatia, September 2015.
  38. †‡BARTOLI CR, Kang J, Restle DJ, Acker MA, Atluri P. Inhibition of ADAMTS-13 by plasma free hemoglobin plus IL-6 reinstates von Willebrand factor: A contributor to LVAD thrombosis? Proceedings of the International Society of Rotary Blood Pumps, Dubrovnik, Croatia, September 2015.
  39. BARTOLI CR, Restle DJ, Kang J, Acker MA, Atluri P. Inhibition of ADAMTS-13 by hemoglobin reinstates normal von Willebrand factor degradation: A contributor to LVAD thrombosis? Proceedings of the International Society of Heart and Lung Transplantation, Nice, France, April 2015.
  40. Zhang D, Restle DJ, Kang J, Shabahang C, Acker MA, Atluri P, BARTOLI CR. LVAD-associated von Willebrand factor degradation alters angiogenesis: A mechanistic link between LVAD support, gastrointestinal angiodysplasia, and bleeding?. Proceedings of the International Society of Heart and Lung Transplantation, Nice, France, April 2015.
  41. Kang J, Zhang DM, Restle DJ, Kallel F, Acker MA, Atluri P, BARTOLI CR. Reduced continuous-flow LVAD speed does not decrease von Willebrand factor degradation. Proceedings of the International Society of Heart and Lung Transplantation, Nice, France, April 2015.
  42. †BARTOLI CR, Restle DJ, Shabahang C, Kang J, Zhang D, Acker MA, Atluri P. Inhibition of ADAMTS-13 with doxycycline may reduce von Willebrand factor degradation during LVAD support: In vitro findings with potential clinical implications. Proceedings of the International Society of Rotary Blood Pumps, San Francisco, CA, September, 2014.
  43. Zhang D, Restle DJ, Kang J, Shabahang C, Acker MA, Atluri P, BARTOLI CR. LVAD support alters endothelial cell behavior: Potential implications for LVAD-associated bleeding? Proceedings of the International Society of Rotary Blood Pumps, San Francisco, CA, September, 2014.
  44. Restle DJ, Zhang D, Shabahang C, Kang J, Acker MA, Atluri P, BARTOLI CR.  Novel in vitro models of human blood trauma demonstrate mechanisms of LVAD-associated von Willebrand factor degradation: Shear stress and enzymatic cleavage. Proceedings of the International Society of Rotary Blood Pumps, San Francisco, CA, September, 2014.
  45. †BARTOLI CR, Restle DJ, Woo YJ, Acker MA, Atluri P. von Willebrand factor degradation with an LVAD occurs via two distinct mechanisms: mechanical demolition and enzymatic cleavage. Proceedings of the International Society of Heart and Lung Transplantation, San Diego, CA, April 2014.
  46. *Dassanayaka S, Sobieski MA, Koenig SC, D’Souza SE, BARTOLI CR.  Potential mechanistic pathway of acquired von Willebrand's disease in patients with a continuous flow LVAD: In vitro findings. Proceedings of Research! Louisville, Louisville, KY, October 2011. 
  47. *Rogers B, BARTOLI CR, Koenig SC, Pantalos GM. Efficacy of Pediatric IABPs in a Pediatric Model of Acute Ischemic Heart Failure. Proceedings of Research! Louisville, Louisville, KY, October 2011.
  48. †BARTOLI CR, Brittian KR, Sobieski MA, Giridharan GA, Wead WB, Prabhu SD, Koenig SC. Acute responses to partial vs. full support of the heart with a continuous-flow LVAD. Proceedings of Biomedical Engineering Society, Hartford, CT, October 2011.
  49. Dassanayaka S, Sobieski MA, Koenig SC, D’Souza SE, BARTOLI CR.  Novel in vitro model to elucidate mechanisms of acquired von Willebrand’s disease with LVAD support. Proceedings of Biomedical Engineering Society, Hartford, CT, October 2011.
  50. Nadar AC, Koenig SC, Prabhu SD, BARTOLI CR. Arterial remodeling in chronic, ischemic heart failure: Implications for heart transplantation and LVAD therapy.  Proceedings of duPont Manual High School Regional Science Fair, Louisville, KY, March 2011.
  51. Giridharan GA, BARTOLI CR, Soucy K, Sobieski MA, Koenig SC, Slaughter MS.  Effects of pulsatile and continuous flow ventricular assist device failure on hemodynamics and end-organ blood flow. Proceedings of The American Society for Artificial Internal Organs, Washington, D.C., June 2011.
  52. Giridharan GA, BARTOLI CR, Spence PA, Koenig SC, Dowling RD. Retrograde cerebral, aortic, and myocardial blood flow during IABP support. Proceedings of The American Society for Artificial Internal Organs, Washington, D.C., June 2011.
  53. *Luckett AJ, BARTOLI CR, Brittian K, Koenig SC, Spence PA, Dowling RD, D’Souza SE. A novel method for quantifying bovine von Willebrand factor and its cleaving protease, ADAMTS-13: Implications for acquired von Willebrand disease in LVAD patients. Proceedings of Research! Louisville, Louisville, KY, October 2010.
  54. *BARTOLI CR, Spence PA, Giridharan GA. Novel J-stents reduce the risk of embolic stroke in vitro. Proceedings of Research! Louisville, Louisville, KY, October 2009.
  55. Slaughter MS, Ising MS, Tamez D, O'Driscoll G, Voskoboynikov N, BARTOLI CR, Koenig SC, Giridharan GA. Reappearance of a normal circadian rhythm after ventricular assist device implantation. Journal of Cardiac Failure. 2009, 15(6): S51.
  56. *BARTOLI CR, Wilson GC, Giridharan GA, Slaughter MS, Sobieski MA, Prabhu SD, Spence PA, Koenig SC. Testing of a subcutaneous counterpulsation device for the treatment of heart failure over a physiological range of hemodynamic conditions.  Proceedings of Research! Louisville, Louisville, KY, October 2008.
  57. Nadar MM, BARTOLI CR, Greenberg RB. Medical school biostatistics and epidemiology curriculum analysis: suggestions for improvement at the University of Louisville. Proceedings of Research! Louisville, Louisville, KY, October 2008.
  58. BARTOLI CR, Koenig SC, Giridharan GA, Slaughter MS, Sobieski MA, Dowling RD, Prabhu SD, Spence PA. Testing of a subcutaneous counterpulsation device for the treatment of heart failure over a physiological range of hemodynamic conditions.  Proceedings of The American Society for Artificial Internal Organs, San Francisco, CA, June 2008.
  59. BARTOLI CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Katz T, Okabe K, Verrier RL, Godleski JJ. Mechanisms of particulate air pollution-induced arterial blood pressure changes.  Proceedings of Research! Louisville, Louisville, KY, October 2007.
  60. BARTOLI CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Katz T, Okabe K, Verrier RL, Godleski JJ. Mechanisms of particulate air pollution-induced arterial blood pressure changes.  Proceedings of The Department of Pathology, Brigham and Women’s Hospital Research Celebration, Boston, MA, May 2007.
  61. *BARTOLI CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Katz T, Okabe K, Verrier RL, Godleski JJ. Godleski. Mechanisms of particulate air pollution-induced arterial blood pressure changes.  Proceedings of The Harvard School of Public Health Symposium, Boston, MA, May 2007. 
  62. Kumar K, BARTOLI CR, Nearing BD, Verrier RL. Antiarrhythmic mechanisms of ranolazine in an in vivo porcine model. New England Electrophysiology Society, Boston, MA, April 2007.
  63. BARTOLI CR, Diaz EA, Lawrence J, Coull BA, Akiyama I, Katz T, Lee LM, Wellenius GA, Verrier RL, Godleski JJ. Increased baroreceptor reflex sensitivity attenuates air pollution induced, α-adrenergic mediated hypertension. Proceedings of The United States Environmental Protection Agency, Role of Air Pollution in Cardiovascular Disease, Durham, NC, October 2006.
  64. BARTOLI CR, Akiyama I, Okabe K, Godleski JJ. Permanent tracheostomy for long-term respiratory studies in canines. Proceedings of The Academy Of Surgical Research, Scottsdale, AZ, September 2006.
  65. BARTOLI CR, Diaz EA, Lawrence J, Katz T, Okabe K, Lee LM, Wellenius GA, Verrier RL, Godleski JJ. Exposure to concentrated ambient air particles raises systemic blood pressure in canines. Proceedings of The American Thoracic Society, San Diego, CA, May 2006.
  66. BARTOLI CR, Diaz EA, Lawrence J, Katz T, Lee LM, Wellenius GA, Verrier RL, Godleski JJ. Exposure to concentrated ambient air particles raises systemic blood pressure in canines. Proceedings of The Harvard School of Public Health, Department of Environmental Health Symposium, Boston, MA, April 2006.

Editorials, Chapters, Case Reports & Books

  1. BARTOLI CR, Anderson M, Dowling RD. The Total Artificial Heart: Bridge-To-Transplant and Destination Therapy for End-Stage Biventricular Heart Failure.  Cardiothoracic Surgery Review. 1st Edition. Lippincott Williams & Wilkins. 2011. Chapter 163: 734-739.

Peer Reviewer For:

  • Nature
  • Circulation: Heart Failure
  • Circulation: Arrhythmia and Electrophysiology
  • Journal of the American College of Cardiology: Heart Failure
  • Annals of Thoracic Surgery
  • Journal Of Heart and Lung Transplantation
  • Journal of Cardiac Failure
  • Artificial Organs
  • American Society for Artificial Internal Organs
  • Catheterization and Cardiovascular Interventions
  • Thrombosis Research
  • Journal of Thrombosis and Hemostasis
  • Clinical and Applied Thrombosis and Hemostasis
  • American Heart Association
  • Journal of Cardiovascular Disease and Diagnosis
  • Journal of Pulmonary & Respiratory Medicine
  • Archives of Toxicology

Grant Support

03/01/19-02/28/21
The von Willebrand Factor-Angiopoietin Axis And Abnormal Angiogenesis In Single Ventricle Disease: Mechanistic Relationships And Potential Target For Therapy                      
Cardiac Center Innovation Award
Children’s Hospital of Philadelphia
Principal Investigator

09/01/18-08/31/20
Chronic In Vivo Study Of A Novel Innovative Pulsatile Total Artificial Heart      
NIH, R21 Grant: R2112570506 (PENDING)
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Co-Investigator

08/28/14-06/21/17
Windmill Mock Circulatory Loop Blood Trauma Testing Windmill Cardiovascular Systems, Incorporated, Sponsored Research Project
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

07/01/17-06/31/18
Pulmonary Arteriovenous Malformations In Patients With A Superior Cavo-Pulmonary Anastomosis: The Role Of Abnormal von Willebrand Factor Big Hearts To Little Hearts
Children’s Hospital of Philadelphia, Department of Cardiothoracic Surgery
Co-Principal Investigator

01/01/17-12/31/17
Determining The Molecular Signals Involved In The Growth And Development Of Systemic-Pulmonary Arterial Collateral Vessels In Children With Single Ventricle Disease Congenital Heart Defects Coalition
Children’s Hospital of Philadelphia, Department of Cardiology
Co-Principal Investigator

12/01/16
Blood Trauma with the BIVACOR Continuous-Flow BiVAD BIVACOR, Incorporated, Sponsored Research Project
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

11/01/16
LVAD-Associated von Willebrand Factor Fragments for Endothelial Cell Growth Mayo Foundation for Research
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator 
                                                                        

10/01/16-09/30/17
Establishing A Standard Practice For The Evaluation Of Von Willebrand Factor Degradation In Continuous-Flow Blood Pumps International Society of Rotary Blood Pumps
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

05/01/16-04/30/19
Development and Preclinical Testing of the TORVAD Ventricular Assist System in Preparation for First in Human Implantation
NIH, SBIR Phase IIB Grant: R44HL117446
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Co-Investigator

01/01/16-11/01/18
EVAHEART Mock Circulatory Loop Blood Trauma Testing: Phase II
EVAHEART, Incorporated, Sponsored Research Project
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

04/01/15-03/31/17
Miniaturization Of The Low-Shear Pulsatile TORVAD For Pediatric Heart Failure
NIH, SBIR Phase II Grant: R44HL127833
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Co-Investigator 
                                                                                                                                                   

06/01/15-09/01/15
Effect of Left Ventricular Assist Device Speed On von Willebrand Factor Degradation University of Pennsylvania, 2015 Abraham Noordergraaf Research Grant
University of Pennsylvania, Department of Bioengineering
Co-Investigator, Mentor to David Zhang

04/01/15-03/31/16
EVAHEART Mock Circulatory Loop Blood Trauma Testing: Phase I
EVAHEART, Incorporated, Sponsored Research Project
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

06/30/14-07/01/14
Mechanisms Of von Willebrand Factor Degradation During LVAD Support: Identification Of Therapeutic Targets To Reduce Bleeding Clinical and Translational Research Center Feasibility Grant Program     
University of Pennsylvania
Principal Investigator

06/01/14-09/01/14
Blood Proteins Exposed To Supraphysiologic Shear Stress From A Left Ventricular Assist Device Alter Endothelial Cell Behavior Center for Undergraduate Research, 2014 Class of 1971 Robert J Holtz Research Grant    
University of Pennsylvania
Co-Investigator, Mentor to David Zhang

06/20/13-06/30/14
Mechanisms Of von Willebrand Factor Degradation, Gastrointestinal Angiodysplasia, And Bleeding in Patients With An LVAD
Cardiovascular Gift Fund                                                   
Hospital of the University of Pennsylvania, Division of Cardiovascular Surgery
Principal Investigator

01/01/11-12/31/15
Harvard University Clear Air Center
EPA Clean Air Research Center Grant: RD-83479801-0
Harvard University, School of public Health
Consultant

01/02/11-05/14/11
Partial vs. Full Support Of The Heart With A Continuous-Flow LVAD
Sponsored Research Tuition Award
University of Louisville, Department of Physiology and Biophysics
Principal Investigator

10/26/09
Novel J-Stents Reduce The Risk Of Embolic Stroke In Vitro
Medical Student Research Award, Research!
University of Louisville School of Medicine
Recipient

07/01/08-08/08/08
Myocardial Recovery With Mechanical Unloading Of The Failing Left Ventricle
NIH T35: ES-14559, Summer Research Scholar Grant
University of Louisville School of Medicine   
Principal Investigator
                                                                                         

07/01/07-08/10/07
Development Of A Bovine Model Of Chronic Ischemic Heart Failure
Summer Research Scholar Grant
University of Louisville School of Medicine
Principal Investigator

06/01/03-08/15/03
Exploration Of The Ionic Mechanisms Governing Ventricular Fibrillation
AHA (Northeast Affiliate) Summer Fellowship Grant
Cornell University, Department of Biomedical Sciences
Principal Investigator

Active IRB Protocols

Abnormal Angiogenesis in Single Ventricle Congenital Heart Disease: Mechanistic Relationships and Potential Targets for Therapy
Children’s Hospital of Philadelphia, IRB pending
PIs: Bartoli, Glatz

Efficacy And Durability Of Embolization Of Systemic-To-Pulmonary Collateral Vessels In Superior Cavo-Pulmonary Connection Patients Prior To Fontan Completion
Children’s Hospital of Philadelphia, IRB #13-009936
PI: Glatz

Placental Growth And Development And Exposure To Environmental Contaminants In Newborns With Congenital Heart Defects
Children’s Hospital of Philadelphia, IRB #16-013652
PI: Gaynor

Randomized Trial of Maternal Progesterone Therapy to Improve Neurodevelopmental Outcomes in Infants with Congenital Heart Disease
Children’s Hospital of Philadelphia, IRB #13-010710
PI: Gaynor

Extracorporeal Membrane Oxygenation (ECMO) Support-Associated Blood Trauma: Identifying Clinical Targets For Therapy
Hospital of the University of Pennsylvania, IRB #825440
PI: Bartoli

Novel Model of LVAD-Like von Willebrand Factor Degradation For The Investigation Of Bleeding In Patients With An LVAD
Hospital of the University of Pennsylvania, IRB #818944
PI: Bartoli