Penn Surgery

Thoracic Surgery Research Laboratory


Exhibit #1: Example of Intraoperative Imaging

We present an example of a patient who came to University of Pennsylvania with a diagnosis of a single nodule in her lung. She had a history of sarcoma, and it was felt that the lung nodule was related to her sarcoma. Below, you can see the picture of the nodule in the left lung:

Traditionally, this patient would go for a minimally invasive surgery to remove her cancer. However, we decided to use intraoperative molecular imaging to look for other cancers that may have been missed on the CAT scan. Therefore, prior to surgery, the patient was injected with a dye that localized to tumor cells. Then, during surgery, molecular imaging was used to identify diseased tissues.

Watch the video of traditional surgery and intraoperative molecular imaging. You can determine if the second nodule is easy to discover with traditional surgery versus surgery using intraoperative molecular imaging:

Once we have found the cancer, we can use state-of-the-art three-dimensional imaging techniques to find the borders of the cancer. This allows us to confirm that we have completely removed the entire tumor: