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Thoracic Surgery Research Laboratory
Harrison Department of Surgical Research
Sunil Singhal, M.D.
  1. Singhal S, Wiewrodt R, Friscia M, Matzie K, Friedberg J, Amin KA, Kucharczuk JC, Albelda SM, Kaiser LR. “Genomic profiling to explain positive PET-18FDG imaging in patients with malignant pleural mesothelioma”.  Journal of Surgical Research 107:284, 2002.
  2. Singhal S, Amin K, Kruklitis R, DeLong P, Friscia ME, Putt ME, Kaiser LR, Albelda SM. “Alterations in Cell Cycle Genes in Early Stage Lung Adenocarcinoma Identified by Expression Profiling.” Cancer Biology and Therapy. 2(3), 2003.
  3. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf G, Albelda SM. “Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice.” American Journal of Respiratory and Cellular Molecular Biology. 28(6):682-696, 2003.
  4. Singhal S, Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda SM. “Microarray Data Simulator to Evaluate Bioinformatic Tools for Selecting Differentially Expressed Genes in Normal versus Cancerous Tissues.” Cancer Biology and Therapy. 2(4): 383-394, 2003.
  5. Paulson EC, Singhal S, Kucharczuk JC, Sterman D, Kaiser LR, Marshall MB. “Bronchial sleeve resection for posttransplant stricture.” Annals of Thoracic Surgery. 76(6):2075-6, 2003.
  6. Singhal S, Weiwrodt R, Malden, L, Matzie K, Friedberg J, Amin KM, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. “Gene Expression Profiling of Malignant Mesothelioma.” Clinical Cancer Research. 9: 3080-3097, 2003.
  7. Singhal S, Amin K, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Albelda SM, Kaiser LR. “Differentially Expressed Apoptotic Genes in Node Negative Lung Adenocarcinoma Predicted by Expression Profiling.” Cancer Biology and Therapy. 2:566-571, 2003.
  8. Cook J, Sterman DH, Singhal S, Smythe WR, Kaiser LR. “Suramin Inhibits The Growth Of Malignant Mesothelioma In Vitro, And In Vivo, In Murine Flank And Intraperitoneal Models.” Lung Cancer. 42(3):263-74, 2003.
  9. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. “Comparison of Stages I-II Thymoma Treated by Complete Resection with or without Adjuvant Irradiation.” Annals of Thoracic Surgery. 76:1635-42, 2003.
  10. Kruklitis R, Singhal S, DeLong P, Kapoor V, Sterman D, Kaiser LR, Albelda SM. “Neoadjuvant Immuno-Gene Therapy with Interferon-Beta Before Surgical Debulking Prevents Recurrence and Improves Survival in Advanced Malignant Mesothelioma.”  The Journal of Thoracic and Cardiovascular Surgery. 127(1): 123-130, 2004.
  11. Lee LS, Singhal S, Brinster CJ, Kaiser LR, Marshall MB, Kochman ML, Kucharczuk JC. “Current Management of Esophageal Leiomyoma.” Journal of American College of Surgeons. 198(1):136-46, 2004.
  12. O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. “Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity.” Oncogene. 24:1244-51, 2005.
  13. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. “Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer.” Clinical Cancer Research. 11: 3974-3986, 2005.
  14. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. “Gene Induction During Differentiation of Human Pulmonary Type II Cells In Vitro.” American Journal of Respiratory Cell & Molecular Biology. 34: 727-737, 2006.
  15. Nathan H, Singhal S, Cameron JL. “Benign pneumatosis intestinalis in the setting of celiac disease.” Journal of Gastrointestinal Surgery. 10(6):890-4, 2006.
  16. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. “A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma.” Clinical Cancer Research. 13(10):2905-15, 2007.
  17. Singhal S, Miller DL, Ramalingam S, Sun SY. “Gene Expression Profiling of Non-Small Cell Lung Cancer.” Lung Cancer. 60: 313-324, 2008.
  18. Fabre D, Fadel E, Singhal S, Monpreville VD, Mussot D, Mercier O,  Chataigner O, Dartevelle PG. “Complete Resection of Pulmonary Inflammatory Pseudotumors Has Excellent Long Term Prognosis.” The Journal of Thoracic and Cardiovascular Surgery. Feb; 137(2):435-40, 2009.
  19. Fabre, D, Singhal S, De Montpreville V, Decante B, Mussot S, Chataigner O, Mercier O, Kolb F, Dartevelle PG and Fadel E.  “Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection.” The Journal of Thoracic and Cardiovascular Surgery 138(1): 32-9, 2009.
  20. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LS, Singhal S, Snyder LA, Albelda SM. “CCL2 Blockade Augments Cancer Immunotherapy.” Cancer Research.  Jan; 70(1):109-118, 2010.
  21. Singhal S. Ferraris VA, Bridges CR, Clough ER, Mitchell JD, Fernando HC, Shrager JB. “Postoperative Management of Pulmonary Alveolar Air Leaks.” Annals of Thoracic Surgery. 89(4): 1327-35, 2010.
  22. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S.  “A Handheld Spectroscopic Device for In Vivo and Intraoperative Tumor Detection: Contrast Enhancement, Detection Sensitivity, and Tissue Penetration.” Analytical Chemistry, Oct 6 2010.
  23. Fridlender ZG, Sun J, Singhal S, Kapoor V, Cheng G, Albelda SM. “Chemotherapy delivered after  viral immunogene therapy augments anti-tumor efficacy via multiple immune-mediated mechanisms.” Molecular Therapy, 18(11): 1947-59, 2010.
  24. Singhal S, Shrager JB. “Intraoperative prophylaxis and management of pulmonary parenchymal air leaks.” Journal of Thoracic and Cardiovascular Surgery. 140(6): 1220-5, 2010.
  25. Singhal S, Nie S, Wang MD. “Nanotechnology applications in surgical oncology.” Annu Rev Med; 61:359-373, 2010.
  26. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, Cohen NA, Mirza N. “Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis.” Otolaryngol Head Neck Surg. 144(6):927-33, 2011.
  27. Brunelli, A. Beretta E, Cassivi S., Cerfolio R., Detterbeck F., Kiefer T.,  Miserocchi G., Shrager J, Singhal S, Raemdonck DV, Varela G. “Consensus definitions to promote an evidence-based approach to management of the pleural space.  A collaborative proposal by the ESTS, AATS, STS, and GTSC.” European Journal of Cardiothoracic Surgery. 40: 291-297, 2011.
  28. Levine S, Budak MT, Dierov J, Singhal S. “Inactivity-induced diaphragm dysfunction and mitochondrial-targeted antioxidants.” Critical Care Medicine. 39(7):1844-5, 2011.
  29. Berman AT, Litzky L, Livolsi V, Singhal S, Kucharczuk JC, Cooper JD, Friedberg JR, Evans TL,  Stevenson J, Metz JM, Hahn SM, Rengan R. “Adjuvant Radiotherapy for Completely Resected Stage II Thymoma.” Cancer. 117(15): 3502-8, Feb 1 2011.
  30. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT.   “Increased proteolysis and atrophic AKT-FOXO Signaling in Human Diaphragm Disuse.”American Journal of Respiratory and Critical Care Medicine. 183(4): 483-90, 2011.
  31. Liu G, Su L, Hao X, Zhong N, Singhal S, Liu X. “Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Programmed Cell Death.” Journal of Cellular and Molecular Medicine. July 31 2011.
  32. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LC, Singhal S, Snyder LA and Albelda SM. “Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells." Am J Respir Cell Mol Biol 44(2): 230-7, 2011.
  33. Aliperti LA, Predina JD, Vachani A, Singhal S. “Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery.” Annals of Surgical Oncology. 18(3): 603-607, 2011.
  34. Su L, Liu G, Hao X, Liu X, Zhong N, Zhong D, Singhal S. “Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells.” European Journal of Cancer. 47(16): 2471-8, 2011.
  35. Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V, Nakagawa H, Rustgi AK, Aguilar L, Aguilar-Cordova E, Albelda SM, Singhal S. “Neoadjuvant in situ Gene-Mediated Cytotoxic Immunotherapy Improves Postoperative Outcomes in Novel Syngeneic Esophageal Carcinoma Models.” Cancer Gene Therapy. 18(12): 871-883. 2011.
  36. Tucker ZCG, Laguna BA, Moon E, Singhal S. “Adjuvant immunotherapy for non-small cell lung cancer.” Cancer Treatment Reviews. 38(6):650-61, 2012.
  37. Fridlender ZG,  Sun  J, Mishalian I, Singhal S, Cheng G,  Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM.   “Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils.”  PLoS ONE. 7(2):e31524. 2012.
  38. Predina JD, Judy B, Kapoor V, Blouin A, Aliperti LA, Levine D, Fridlender ZG, Singhal S. “Characterization of Surgical Models of Postoperative Tumor Recurrence For Preclinical Adjuvant Therapy Assessment.” Am J Translational Research. 4(2): 206-218, 2012.
  39. Jia G, Su L, Singhal S, Liu X. “Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging.” Molecular and Cellular Biochemistry. 364(1-2): 345-350, 2012.
  40. Predina JD, Fridlender ZG, Judy B, Kapoor V, Aliperti L, Blouin A, Albelda SM, Singhal S. “The Importance of Well-Characterized Murine Surgical Models of Tumor Recurrence for Preclinical Studies of Adjuvant Therapy.” Cancer Biology and Therapy. 13(9):1-11, 2012.
  41. O'Shannessy D J, Yu G, Smale R, Fu YS, Singhal S, Thiel RP, Somers EB, and Vachani A. “Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance.” Oncotarget. 3(4):414-25, 2012.
  42. Predina JD, Kapoor V, Judy BF, Cheng G, Fridlender ZG, Albelda SM, Singhal S. “Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness.” Journal of Hematology and Oncology. 5(1): 34, 2012.
  43. Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, Singhal S. “Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery.” Neoplasia. 14(4): 352-9, 2012.
  44. Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk J, Singhal S, Vachani A. “MicroRNA expression profiles of whole blood in lung adenocarcinoma.” PLOS One. 7(9): e46045, Sept 2012.
  45. Majumdar D, Singhal S. “Medicinal Chemistry and Nanomedicine for Reproductive Cancer Therapeutics.” Front Biosci (Elite Ed). 4: 2029-44, 2012.
  46. Madajewski B, Judy B, Mouchli A, Kapoor V, Holt D, Wang MD, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease.” Clinical Cancer Research. 18(20): 5741-51. Oct 15, 2012.
  47. Laguna BA, Tucker ZCG, DeLisser H, Singhal S. "Letting the Air in Can Set the Stage for Tumor Recurrences.” Current Cancer Therapy Reviews. 8(4):293-303, Nov 2012.
  48. Fabre D, El Batti S, Singhal S, Mercier O, Mussot O, Fadel E, Kolb F, Dartevelle PG. “A paradigm shift for sternal reconstruction using a novel titanium rib bridge system following oncological resections.” European Journal of Cardiothoracic Surgery. 42(6):965-70. Dec 2012.
  49. Fridlender Z, Jasaar A, Mishalian I, Wang LC, Kapoor V, Cheng G, Sun J, Singhal S, Levy L, and Albelda SM. “Using Macrophage Activation to Augment Immunotherapy of Established Tumors.” British Journal of Cancer. 108(6):1288-97, April 2, 2013.
  50. Levine S, Bashir M, Clanton T, Powers S, Singhal S.  “COPD Elicits Remodeling of the Diaphragm and Vastus Lateralis Muscles in Humans.”  Journal of Applied Physiology. 114(9): 1235-1245.  May 1, 2013.
  51. Ghosh A, Philiponis G, Lee JY, Leahy KP, Singhal S, Cohen NA, Mirza N. "Pulse steroid therapy inhibits murine subglottic granulation." Otolaryngol Head Neck Surg. 148(2): 284-90. Feb 2013.
  52. Li T, Su L, Zhong N, Singhal S, Liu X “Salinomycin Induces Cell Death with autophagy through activation of Endoplasmic Reticulum Stress in Human Lung Cancer cells.” Autophagy. 9(7). April 18, 2013.
  53. Predina JD, Eruslanov E, Judy B, Kapoor V, Cheng GJ, Wang S, Sun J, Fridlender G, Albelda SM, Singhal S. “Changes in the Local Tumor Microenvironment in Recurrent Cancers May Explain the Failure of Vaccines after Surgery.” Proceedings of the National Academy of Sciences USA. 110(5): E415-24. Jan 29, 2013.
  54. Quatromoni JG, Suzuki E, Okusanya O, Judy BF, Bhojnagarwala P, Venegas O, Eruslanov E, Predina JD, Albelda SM, Singhal S. “The timing of TGF-β inhibition affects the generation of antigen-specific CD8+ T Cells.” BMC Immunology. 14:30, 2013.
  55. Waldron TJ, Quatromoni JG, Karakasheva TA, Singhal S, and Rustgi, AK. “Myeloid derived suppressor cells: Targets for therapy.” Oncoimmunology, 2: e2411-7, 2013.
  56. Liu Y, Wang L, Predina J, Han R, Beier UH, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. “Inhibition of p300 Impairs Foxp3+ T-regulatory Cell Function and Promotes Anti-Tumor Immunity.” Nature Medicine. 19(9):1173-7. Sept 2013.


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