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Current PARC Studies

Trauma Induced Coagulopathy and Inflammation (TrICI) Trial
PI: Carrie Sims, MD, PhD, Trauma Surgery - Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
A prospective observational study designed to evaluate the factors that contribute to the
development of trauma induced coagulopathy (TIC), post injury inflammation and organ dysfunction in adult trauma patients in order to develop a multi scale computational algorithm and ex vivo models capable of clinical prediction.

Evaluation of Hemostatic Thrombus Formation
PI: Carrie Sims, MD, PhD - Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
A prospective descriptive study investigating the morphological features of platelets and hemostatic plugs using a small vascular injury model in humans undergoing elective bowel resection surgery.

Observational Convenience Sample Study of Mechanical CPR in the Medical Intensive Care Unit
PI: Benjamin Abella, MD, MPhil - Department of Emergency Medicine
A pilot study testing the feasibility and utility of mechanical CPR in cardiac arrest patients using the LUCAS device in the Medical Intensive Care Unit (MICU).

The Established Status Epilepticus Treatment Trial (ESETT)
PI: Jill Baren, MD - Department of Emergency Medicine
A multicenter, randomized, double-blind, study to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus among patients.

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SAGE-547 Injection in the Treatment of Subjects with Super-Refractory Status Epilepticus (SRSE)
PI: Joshua Levine, MD - Department of Neurology
A multicenter randomized, double-blind clinical trial to determine the response to a 6 day continuous intravenous infusion of SAGE-547 compared to placebo administered to support the weaning of all third-line agents in adult and pediatric subjects with SRSE, and for the response to endure at least 24 hours after the end of the SAGE-547 or placebo infusion.

The SCARLET Trial: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of ART-123 in Subjects with Severe Sepsis and Coagulopathy
PI: Niels Martin, MD - Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
A multicenter randomized, double-blind clinical trial to evaluate whether Thrombomodulin alfa (ART-123), when administered to subjects with bacterial infection complicated by at least one organ dysfunction and coagulopathy, can reduce mortality and to evaluate the safety of ART-123 in this population.

The natural history of endothelial progenitor cell mobilization and cerebral microvascular injury
after traumatic brain injury
PI: Danielle Sandsmark, MD, PhD - Department of Neurology
A prospective observational study to examine the natural history of EPC mobilization and neuroimaging markers of traumatic vascular injury in the acute, subacute and chronic stages after TBI.

Alterations in mitochondrial bioenergetics and dynamics in blood cells obtained from emergency department patients with sepsis
PI: David Jang, MD, MSc; John Greenwood, MD - Department of Emergency Medicine
A prospective observational study aims to explore the logistics of measuring mitochondrial respiration that fits in an analytical timeframe to identify clinical abnormalities or to help guide therapy as well as evaluate changes in mitochondrial bioenergetic function (respiration and ROS) and dynamics (movement, localization, and rates of fission/fusion events).

Necroptosis and cell-free DNA in the pathogenesis of organ dysfunction after trauma
PI: Michael Shashaty, MD, MSCE - Department of Medicine 
A prospective observational study to determine if necroptosis and consequent plasma damage-associated molecular pattern (DAMP) release plays an early pathophysiologic role in the development of AKI and ARDS in trauma patients.

 
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