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Urology Research Laboratory
Harrison Department of Surgical Research
Dr. Samuel K. Chacko
George M. O'Brien Program

The George M. O'Brien Urology Research Center at the University of Pennsylvania is entitled ”Bladder Wall Remodeling in LUTS“ and has four key elements:

  1. The laboratories of five principal investigators and their co-investigators that bring expertise in molecular biology, cellular biology, neuroscience, biochemistry, physiology, pharmacology, and pathology.
  2. An Administrative Core (Core A) to provide administrative and fiscal oversight, quality control for the research within individual projects and coordination of the research and interactions in the Urology Center.
Organizational Structure
Interrelationships of Various Components
  1. A Bladder Tissue Core (Core B) to serve as resource for smooth muscle tissue from rabbits and mice (normal and obstructed urinary bladders during phases of compensation, decompensation, and reversal of the obstruction after surgery), as well as human bladder tissue from surgical specimen. The Bladder Tissue Core will not only serve the investigators in the program but also provide other urology investigators bladder tissues from obstructed animals for pilot and feasibility studies and collaborative research. The Bladder Tissue Core will provide the advice on animal models for urologic research and hands-on training for urology investigators to perform partial bladder outlet obstruction in small mammals. (PI, Stephen A. Zderic, M.D.)
  2. Educational and Enrichment Program: Organize seminars and conferences in basic and translational research in urology. The intent of this program is to bring established researchers and young investigators from other disciplines in contact with basic and clinical urology researchers. In addition, external speakers who are actively interested in basic and translational research in urology are invited as speakers.
Upcoming Events
The overall objective of our research program is to elucidate the cellular/molecular basis for the alteration in various components (urothelium, nerves, and detrusor smooth muscle) of the lower urinary tract in LUTS.


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