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Urology Research Laboratory
Harrison Department of Surgical Research
Dr. Samuel K. Chacko
Affiliated Faculty/Investigators
Edward F. LaBelle, Ph.D.

Assistant Professor, Biology
Gloucester County College
Visiting Scientist/Summer Research Faculty
Division of Urology, Department of Surgery
University of Pennsylvania School of Medicine
1400 Tanyard Rd.
Sewell, NJ 08018
Phone: 856-415-2169

1970 AB, MS, Chemistry
Holy Cross College
Worcester, Massachusetts
1974 PhD, Biochemistry
University of Michigan
Ann Harbor, Michigan
1976 Postdoctoral Fellowship, Biochemistry
Cornell University
Ithaca, New York
Research Interest

Dr. LaBelle is interested in the control of vascular smooth muscle contraction and cellular growth and apoptosis by lipid-dependent second messengers. These lipid-dependent second messengers include products of phospholipase C activity such as IP3 and diacylglycerol as well as products of phospholipase D activity such as phosphatidic acid and lysophosphatidic acid and the products of phospholipase A2 activity such as arachidonic acid and prostaglandins.

Selected Publication
  1. Gu H, Trajkovic S, and LaBelle EF. (1992) Norepinephrine-induced phosphatidylcholine by phospholipases D and C in rat tail artery. Am J Physiol. 262(6 Pt 1):C1376-83.
  2. Baron CB, Ozaki S, Watanabe Y, Hirata M, LaBelle EF, and Coburn RF. (1995) Inositol 1,4,5-triphosphate binding to porcine tracheal smooth muscle aldolase. J Biol Chem. 270(35):20459-65.
  3. LaBelle E.F., Fulbright R.M., Barsotti R.J., Gu H. and Polyak, E. (1996) Phospholipase D is activated by G protein and not by calcium ions in vascular smooth muscle Am J Physiol. 270(3 Pt 2):H1031-7.
  4. LaBelle E.F. and Polyak E. (1996) Phospholipase C beta 2 in vascular smooth muscle. J Cell Physiol. 169(2):358-63.
    Coburn RF, LaBelle EF, Griffiths T 2nd, and Baron CB. (1997) Smooth muscle sarcolema-associated phospholipase C-beta 2; agonist-evoked translocation. Am J Physiol. 171(3):271-83.
  5. LaBelle E.F. and Polyak E. (1998) Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2 Am J Physiol. 274(4 Pt 1): C1129-37.
  6. LaBelle E.F. and Polyak E. (1999) Activation of CPLA2 in vascular smooth muscle. Adv Exp Med Biol. 469:177-82.
  7. LaBelle E.F., Wilson K , and Pilane C. (2002) Apoptosis in vascular smooth muscle accompanied by increase in arachidonic acid. Adv Exp Med Biol. 507:433-7.
  8. LaBelle E.F. Wilson K , and Polyak E. (2002) Subcellular Localization of Phospholipase C Isoforms Vascular Smooth Muscle. Biochim Biophys Acta. 1583(3): 273-8.
  9. Pilane CM and LaBelle EF. (2002) Arachidonic acid release by cPLA2 may be causally related to NO-induced apoptosis in vascular smooth muscle cells. J Cell Physiol. 191(2):191-7.
  10. LaBelle, E.F. and Tulenko, T.N. (2004) LDL, IGF-1 and VSMC Apoptosis: linking atherogenesis to plaque rupture vulnerable lesions. Cardiovasc.Res. 61: 204-205.
  11. Pilane CM and LaBelle EF. (2004) cPLA2 activator peptide, PLAP, increase arachidonic acid release and apoptosis of vascular smooth muscle cells, J Cell Physiol. 198(1):48-52.
  12. Pilane CM and LaBelle EF. (2004) NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. J Cell Physiol. 199(2): 310-5.
  13. Zhu P, Liu X, LaBelle EF, and Freedman, BD. (2005) Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells. J Immunol. 175(8):4981-9.
  14. Pilane CM and LaBelle EF. (2005) Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids. J Cell Physiol. 204(2):423-7.
  15. Tulenko T.N., Boeze-Battaglia K., Mason, R.P., Tint, G.S., Steiner, R.D., Connor, W.E., and LaBelle, E.F. (2006) A membrane defect in the pathogenesis of the Smith-Lemli-Opitz syndrome. J Lipid Res. 47(1):134-43.
  16. LaBelle, E, Zderic,S., Delaney, D., Hypolite, J., Wein, A. and Chacko, S.(2006) Lipid Signaling Changes in Smooth Muscle Remodeling Associated with Partial Urinary Bladder Outlet Obstruction. Neurourol and Urodyn. 25(2):179-184.
  17. Coburn RS, LaBelle E.F., and Baron CB (2006) Polyamines, PI(4,5)P2, and actin polymerization. J.Cell Physiol. 209(2):405-12.
  18. Shenker B.J., Dlakic M., Walker L.P., Besack D., Jaffe E., LaBelle E., and K. Boeze-Battaglia. (2007) A Novel Mode of Action for a Microbial-Derived Immunotoxin: The cytolethal Distending Toxin Subunit B inhibit Phosphatidylinositol 3,4,5 Trisphosphate Activity. J.Immunol. 178(8): 5099-108.
  19. Hypolite JA, Chang S, LaBelle E, Babu GJ, Periasamy M, Wein AJ, Chacko S. (2009) Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle. Am J Physiol Renal Physiol. 296(3):F658-65.
  20. Basha M, LaBelle EF, Northington GM, Wang T, Wein AJ, Chacko S. (2009) Functional significance of muscarinic receptor expression within the proximal and distal rat vagina. Am J Physiol Regul Integr Comp Physiol. 297(5):R1486-93.


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