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Neurourology Research Laboratory
Harrison Department of Surgical Research
Anna P. Malykhina, Ph.D.
Center Projects

The Philadelphia IR-BU Center is focused on understanding the systemic and cellular mechanisms of neurogenic bladder dysfunction resulting from degeneration in the central nervous system (CNS) and functional interplay between the urologic and nervous systems.

Project 1 (PI - Malykhina, Anna) studies the effects of pathological changes in the CNS on bladder sensory pathways and impaired neurological control of the urinary bladder function. 

Project 2 (PI - Ruggieri, Michael) investigates the motor dysfunctions of the LUT in an animal model of the central nervous system degeneration.

Project 3 (PI - Smith, Ariana) is focused on LUTS in patients with neurogenerative diseases, progression and correlation of the LUTS with location/volume of CNS lesions.


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