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Daniel N. Holena, M.D.
Traumatology, Surgical Critical Care and Emergency Surgery

 
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Administrative Office:
Penn Presbyterian Medical Center
51 N. 39th Street
Medical Office Building 1st Floor, Suite 120
Philadelphia, PA 19104
Administrative Assistant: Lizette Alicea
Administrative Telephone: 215-662-8886
Administrative Fax: 215-243-4679

Patient Appointments: 215-662-7320

Clinical Offices:
Hospital of the University of Pennsylvania
3400 Spruce Street, Maloney 5th Floor
Philadelphia, PA 19104

Perelman Center for Advanced Medicine
34th and Civic Center Boulevard
West Pavilion, 2nd and 4th Floors
Philadelphia, Pennsylvania, 19104

Penn Medicine at University City
3737 Market Street, 4th Floor
Philadelphia, Pennsylvania, 19104

Contact Information (internal use only)

daniel.holena@uphs.upenn.edu

 

Dr. Daniel Holena is board certified in General Surgery and Surgical Critical Care. He received his General Surgery training at Cornell, and completed is fellowship in Trauma Surgery and Surgical Critical Care at the University of Pennsylvania. Dr. Holena specializes in the treatment of traumatic injury, emergency general surgery conditions, and surgical critical care. His research interests include outcomes after emergency general surgery and triage biomarkers in acute trauma.

 
Faculty Appointments
Nov. 2013 - present   Fellow, Leonard Davis Institute of Health Economics
 
2009 - present Assistant Professor of Surgery at HUP
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2007 - 2009  Instructor B in Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2013 - present   Center for Emergency Care Policy Research, Faculty
 
2013 - present  Department of Surgery Representative, Telemedicine Committee
 
2012 - present   Member, ad hoc Code Improvement Committee
 
2011 - present   Member, Clinical Emergencies Committee
 
2011 - present   Director of Audiovisual Video Review, Division of Trauma
 
2011 - present Director of Surgical Rapid Response, Hospital of the University of Pennsylvania
 
2011 - present  Physician Leader, Unit Based Clinical Leadership Silverstein 12
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
 

2009 - present 

Attending Intensivist, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2008 - present  Attending Intensivist, Penn e-lert eICU, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
2008 - present  Attending Trauma Physician, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2008 - 2009  Senior Administrative Fellow, Division of Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia,Pennsylvania
 
Editorial Positions
2011 - present Ad Hoc Reviewer, Injury
 
2011 - present Editor,  Journal of Trauma and Treatment
 
Education/Training
2013 - present MSCE, Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
 
2013 - 2014 Penn Medicine Leadership Academy
 
2009 - 2011 Research Certificate, Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
 
1998 - 2002 MD - State University of New York at Stony Brook
Stony Brook, New York
 
1991 - 1995 BS - McGill University
Montreal, Canada (Biology)


Postgraduate Training and Fellowship Appointments
2007 - 2009 Fellowship in Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2003 - 2007 Resident in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
 
2002 - 2007 Rotating Resident in Surgical Oncology
Memorial Sloan-Kettering Cancer Center
New York, New York
 
2002 - 2003 Internship in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
 
Other Appointments
1998 - 2001 Student Representative, Class of 2002
State University of New York at Stony Brook School of Medicine
Stony Brook, New York
 
2008 - 2009 Instructor B in Surgery
University of Pennsylvania School of
 
Memberships/Societies
 
National/International Societies
  Eastern Association for the Surgery of Trauma
 
 

Society of Critical Care Medicine
Surgical Section

 
  American College of Surgeons
 
  American Medical Association
 
  Association of Academic Surgeons
 
 

European Society for Trauma and Emergency Surgery
Visceral Trauma Section

 
Local/Regional Societies
  Pennsylvania Medical Society
 
Scientific Committees
2013 Thoracic and Lumbar Spine Practice Management Guideline Committee
Eastern Association for the Surgery of Trauma
 
2014 Emergency General Surgery Task Force of the Guidelines Committee EAST
 
2014 - 2016 Publications Committee, Association for Academic Surgery
 
Research
Research Funding
2015 - 2016 Penn Injury Science Center Pilot Grant“Patient experiences of Trauma Resuscitations”   Role: PI
 
2015 - 2016 Laerdral Corporation “An innovative leadership dyad for in-hospital cardiac arrest to improve code team process variables and clinical outcomes”.   Role: Co-I
 
2013 - 2015 NHLBI   K-12 Scholarship (K12 HL 109009)
 
2014 - 2014   Leonard Davis Institute High Risk/Innovation Grant
 
2013 - 2014  CTSA/CCEB -2014 PCOR Pilot Grant 
 
 
Publications
 
Research Publications, Peer Reviewed
  1. Whalen W, Holena D, Pryor JP. Cardiac injury. Severe blunt chest trauma leads to cardiac arrest. JEMS : a journal of emergency medical services 2008;33. PMID: 18692728
  2. Pieracci FM, Henderson P, Rodney JR, Holena DN, Genisca A, Ip I, Benkert S, Hydo LJ, Eachempati SR, Shou J, Barie PS. Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anemia and risk of infection during surgical critical illness. Surgical infections 2009;10:9-19. PMID: 19245362
  3. Holena DN, Hadler R, Wirtalla C, Carr B, Morris JB, Kelz RR. Teaching status: The impact on emergency and elective surgical care in the US. Annals of Surgery 2011;253:1017-23. PMID: 21451392
  4. Holena DN, Mills AM, Carr BG, Wirtalla C, Sarani B, Kim PK, Braslow BM, Kelz RR. Transfer status: A risk factor for mortality in patients with necrotizing fasciitis. Surgery 2011;150:363-70. PMID : 21783216
  5. Mills AM, Edwards JM, Shofer FS, Holena DN, Abbuhl SB. Analgesia for older adults with abdominal or back pain in the emergency department. Western Journal of Emergency Medicine 2011;12:43-50. PMID: 21691471
  6. Mills AM, Shofer FS, Boulis AK, Holena DN, Abbuhl SB. Racial disparity in analgesic treatment for ED patients with abdominal or back pain. American Journal of Emergency Medicine 2011;29:752-6. PMID: 20825892
  7. Pascual JL, Holena DN, Vella MA, Palmieri J, Sicoutris C, Selvan B, Fox AD, Sarani B, Sims C, Williams NN, Schwab CW. Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit. Journal of Trauma - Injury, Infection and Critical Care 2011;71:330-8.          PMID: 21825935
  8. Holena D, Stoddard D, Martin ND, Winters B, Casey J, Pascual J, Sims C, Sarani B. Clinical outcomes following invasive versus noninvasive preoperative stabilization of closed diaphyseal femur fractures. European Journal of Trauma and Emergency Surgery 2012:1-4.
  9. Holena DN, Netzer G, Localio R, Gallop RJ, Bellamy SL, Meyer NJ, Shashaty MGS, Lanken PN, Kaplan S, Reilly PM, Christie JD. The association of early transfusion with acute lung injury in patients with severe injury. Journal of Trauma and Acute Care Surgery 2012;73:825-31. PMID : 23014528
  10. Holena DN, Tolstoy N, Mills AM, Fox A, and Levine J.  Cooler heads prevail: A case of intractable intracranial hypertension after liver transplantation treated with therapeutic hypothermia.  Am J Crit Care 21 (1): 75-76, 2011
  11. Massey PR, Sakran JV, Mills AM, Sarani B, Aufhauser Jr DD, Sims CA, Pascual JL, Kelz RR, Holena DN. Hyperbaric oxygen therapy in necrotizing soft tissue infections. Journal of Surgical Research 2012;177:146-51. PMID: 22487383
  12. Mollo EA, Reinke CE, Nelson C, Holena DN, Kann B, Williams N, Bleier J, Kelz RR. The simulated ward: Ideal for training clinical clerks in an era of patient safety. Journal of Surgical Research 2012;177:E1-E6. PMID: 22524978
  13. Sakran JV, Holena DN, and Dickinson E.  Collaboration makes survival possible for thoracic injury patient.  Journal of Emergency Medical Services 33(8):28-31, March. 2012.     PMID: 22734270
  14. Morris DS, Schweickert W, Holena D, Handzel R, Sims C, Pascual JL, Sarani B. Differences in outcomes between ICU attending and senior resident physician led medical emergency team responses. Resuscitation 2012;83:1434-7.  PMID: 22841611
  15. Shashaty MGS, Meyer NJ, Localio AR, Gallop R., BellamySL, Holena DN, Lanken PN, Kaplan S, Yarar D, Kawut SM, Feldman HI, Christie JD.  African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients.  Journal of Critical Care 27 (5), pp. 496-504 PMID : 22591570
  16. Sixta S, Moore FO, Ditillo MF, Fox AD, Garcia AJ, Holena D, Joseph B, Tyrie L, Cotton B. Screening for thoracolumbar spinal injuries in blunt trauma: An Eastern Association for the Surgery of Trauma practice management guideline. Journal of Trauma and Acute Care Surgery 2012;73:S326-S32. PMID : 23114489
  17. Gallesio JMA, Holena DN, Huang J, Sims C, Levine J, Ying GS et al. Erratum: Hypertonic saline is superior to mannitol in severe traumatic brain injury for hourly correction of intracranial pressure and cerebral perfusion pressure and brain oxygenation (Journal of the American College of Surgeons 215 (S54)). Journal of the American College of Surgeons. 2013;216(1):176.
  18. Georgoff P, Perales P, Laguna B, Holena D, Reilly P, Sims C. Colonic injuries and the damage control abdomen: Does management strategy matter? Journal of Surgical Research. 2013;181(2):293-9. PMID: 22884449
  19. Johnson NJ, Carr BG, Salhi R, Holena DN, Wolff C, Band RA. Characteristics and outcomes of injured patients presenting by private vehicle in a state trauma system. American Journal of Emergency Medicine 2013;31:275-81. PMID : 23000329
  20. Mills AM, Holena DN, Kallan MJ, Carr BG, Reinke CE, Kelz RR. Effect of insurance status on patients admitted for acute diverticulitis. Colorectal Disease. 2013;15(5):613-20.
  21. Sensenig RL, Tolstoy NS, Holena DN. A spontaneously expelled bullet from the urethra: A case of undetected bladder injury after abdominal gunshot wound. Injury Extra. 2013;44(6):58-9..
  22. Sims CA, Isserman JA, Holena D, Sundaram LM, Tolstoy N, Greer S, Sonnad S, Pascual J, Reilly P. Exception from informed consent for emergency research: Consulting the trauma community. Journal of Trauma and Acute Care Surgery 2013;74:157-66. PMID : 23271091
  23. Tolstoy NS, Aized M, McMonagle MP, Holena DN, Pascual JL, Sonnad SS et al. Mineralocorticoid deficiency in hemorrhagic shock. Journal of Surgical Research. 2013;180(2):232-7. PMID: 22683082
  24. Jacovides CL, Bruns B, Holena DN, Sims CA, Wiebe DJ, Reilly PM et al. Penetrating trauma in urban women: Patterns of injury and violence. Journal of Surgical Research. 2013;184(1):592-8. PMID :23890398
  25. Ebbeling L, Grabo DJ, Shashaty M, Dua R, Sonnad SS, Sims CA et al and Holena DN. Psoas:lumbar vertebra index: central sarcopenia independently predicts morbidity in elderly trauma patients. European Journal of Trauma and Emergency Surgery. 2013:1-9.
  26. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA et al and Holena DN Interhospital transfer: An independent risk factor for mortality in the surgical intensive care unit. American Surgeon. 2013;79(9):909-13 PMID : 24069990
  27. Davis L,  Johnson L, Allen SR., Kim PK., Sims CA, Pascual JL, Holena, DN.  Practitioner Perceptions of Trauma Video Review.  Journal of Trauma Nursing. 2013 ;(3) :150-154 PMID : 24005118
  28. Band RA, Salhi RA, Holena DN, Powell E, Branas CC, Carr BG. Severity-Adjusted Mortality in Trauma Patients Transported by Police. Annals of Emergency Medicine 2014. PMID: 24387925
  29. Bruns BR, DuBose J, Pasley J, Kheirbek T, Chouliaras K, Riggle A, Frank MK, Phelan HA, Holena D, Inaba K, et al. Loop versus end colostomy reversal: has anything changed? European Journal of Trauma and Emergency Surgery. 2014.
  30. Reilly JP, Meyer NJ, Shashaty MG, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena DN, Reilly MP, Christie JD. ABO Blood Type A is Associated with Increased Risk of Acute Respiratory Distress Syndrome in Caucasians Following both Major Trauma and Severe Sepsis. PMID: 24385226
  31. Pascual JL, Blank NW, Holena DN, Robertson MP, Diop M, Allen SR, Martin ND, Kohl BA, Sims CA, Schwab CW, Reilly PM. There's no place like home: Boarding surgical ICU patients in other ICUs and the effect of distances from the home unit J Trauma Acute Care Surg. 2014 Apr;76(4):1096-102.  PMID:24662877
  32. Sonnenberg EM, Reinke CE, Bartlett EK, Collier KT, Karakousis GC, Holena DN, Kelz RR. Wind, water, wound, walk - Do the data deliver the dictum? Journal of Surgical Education. 2014;72(1):164-169.  PMID: 25131719
  33. Shashaty MGS, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD. Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically Ill trauma patients. Critical Care Medicine. 2014;42(7):1619-1628.  PMID:230013
  34. Reilly JP, Bellamy S, Shashaty MGS, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD. Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Annals of the American Thoracic Society. 2014;11(5):728-736.  PMID: 4225810
  35. Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Critical Care Medicine. 2014;42(9):2048-2057. PMID: 24797376
  36. Kim L, Schuster J, Holena D, Sims C, Levine J, Pascual J. Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on brain imaging. Journal of Emergencies, Trauma and Shock. 2014;7(3):141-148. PMID: 4156017
  37. Vioque SM, Kim PK, McMaster J, Gallagher J, Allen SR, Holena DN, Reilly, PM, Pascual JL.  Classifying errors in preventable and potentially preventable trauma deaths:  a 9 year review using the Joint Commission’s standardized methodology.  Am Journal of Surgery 208(2):187-97, 2014 August
  38. Kuo LE, Simmons KD, Holena DN, Karakousis G, Kelz RR. A risk prediction model for mortality in the moribund general surgical patient. J Crit Care. 2015;30(2):310-314.  PMID: 25499416
  39. Folkert IW, Sims CA, Pascual JL, Allen SR, Kim PK, Schwab CW, Holena DN. Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study. European Journal of Trauma and Emergency Surgery 2014.
  40. Allen SR, Scantling DR, Delgado MK, Mancini J, Holena DN, Kim P, Pascual JL, Reilly P. Penetrating torso injuries in older adults: increased mortality likely due to “failure to rescue”. European Journal of Trauma and Emergency Surgery 2015.
  41. Jacovides CL, Nadolski G, Allen SR, Martin ND, Holena DN, Reilly PM, Trerotola S, Braslow BM, Kaplan LJ, Pascual JL.  Arteriography for lower gastrointestinal hemorrhage role of preceding abdominal computed tomographic angiogram in diagnosis and localization.  JAMA, 150(7):650-656. 2015
  42. Simmons KD, Hoffman RL, Kuo LE, Bartlett EK, Holena DN, Kelz RR.  Is a Colectomy Always Just a Colectomy? Additional procedures as a proxy for operative Complexity.  American College of Surgeons. In press 2015
  43. Leary, M, Schwickert, W, Falk, S, Holena, DN, Neefe, S, Tsypenyuk, B.  Improving provider role definitions to decrease overcrowding and improve in-hospital cardiac arrest response.  American Journal of Critical Care.  Accepted.
  44. Holena DN Leary M, , Neefe S, Tsypenyuk B, Schweickert W, Falk S.  An Embarrassment of Riches:  Rethinking the in-hospital cardiac arrest response to decrease overcrowding and improve provider role definitions.  Am Journal of Critical Care. (Submitted).
  45. Delgado M, Padrez K, Holena DN, Grossestreuer A, Dahodwala N, Carr B.  Characteristics and Disposition of Severely Injured Elderly Patients Presenting to U.S. Non-Trauma Centers by Mechanism of Injury.  Academic Emergency Medicine. (Submitted).
  46. Stelson EA, Carr BG, Golden KA, Martin ND, Richmond TS, Delgado MK, Holena DN.  Stakeholder Perceptions of Family Participation in ICU Rounds and Telemedicine: A Qualitative Assessment.  American Journal of Critical Care Medicine.  (Submitted). 
  47. Holena DN, Earl-Royal EC, Delgado MK, Sims CA, Pascual JL, Carr BG, Reilly PM, Wiebe DJ.  Failure to Rescue in Trauma:  Coming to Terms with the Second Term.  Injury.  (Submitted)
  48. Reilly J, Anderson B, Mangalmurti N, Nguyen DT, Holena DN.  The ABO Histo-Blood Group and Acute Kidney Injury in Critically Ill Trauma and Sepsis Patients.  Clinical Journal of the American Society of Nephrology. (Submitted)
  49. Bowman A, Weibe D, Wolff C, Mullen MT, Holena DN, Branas CC, Carr B.  Disparities in Access to Trauma Care in the United States:  A Population Based Analysis.  Annals of Surgery. (Submitted)
  50. Simmons KD, Kuo LE, Hoffman RL, Bartlett EK, Holena DN, Kelz RR. Methodological Considerations in Outcomes Research: Timing of Operation.  (Submitted)
  51. Pascual JL, Hochman BR, Barry ME, Lane-Fall MB, Allen SR, Holena DN, Kaplan LJ, Smith BP.  Handoffs in the Intensive Care Unit: Are Off Hours a Vulnerable Time.  American Journal of Surgery. (Submitted).
  52. Bores S, Pajerowski W, Carr B, Holena D, Meisel Z, Mechem C, Band R. The Association of Prehospital IV Fluids and Mortality in Patients with Penetrating Trauma.  Academic Emergency Medicine. (Submitted).
  53. Mancini DJ, Sims CA, Pascual JL, Reilly PM, Holena DN.  In for a Penny, In for a Pound: Outcomes after Supra-Massive Transfusion are equivalent to outcomes after Massive Transfusion.  European Journal of Trauma. (Submitted)
  54. Kuo LE, Simmons KD, Holena DN, Kelz RR.  Bariatric Centers of Excellence: The Effect of Centralization on Access to Care. Journal of the American College of Surgeons. (Submitted).
Reviews in Peer Reviewed Research Publications
(print or other media)
  1. Allen S, Holena D, McCunn M, Kohl B, Sarani B. A review of the fundamental principles and evidence base in the use of Extracorporeal Membrane Oxygenation (ECMO) in critically Ill adult patients. Journal of Intensive Care Medicine 2011;26:13-26.
  2. Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Critical Care Medicine. 2014;42(9):2048-2057. PMID: 24797376
Contributions to Peer-Reviewed Clinical Research Publications, Participation Cited but not by Authorship
  1. Lemos-Filho LB, Mikkelsen ME, Martin GS, Dabbagh O, Adesanya A, Gentile N, Esper A, Gajic O, Gong MN. Sex, Race, and the Development of Acute Lung Injury.Chest 143 (4) 901-909, 2012. PMID: 23117155
Research Publications, Non-Peer Reviewed
  1. Weinberger LN, Holena DN, Powell EK, Gracias V.  Arc determination equals injury identification: Trauma mantra applied to electrocution. Injury Extra 39:389-391, 2008.
  2. Holena DN, Perman S, Hankin A, and Schwab CW.  An unusual cause of airway obstruction.   Injury Extra 40 (9): 168-169, 2009.
  3. Holena DNand Braslow B.  Cecal bleeding as a complication of conservative management of acute colonic pseudo-obstruction.  Internet Journal of Emergency Medicine.  5(2):  2009.
  4. Pascual JL, Holena DN, Del Portal D, and Schwab CW.  Blunt intrapericardial superior vena cava injury: a trap for the unwary. Injury Extra 41 (1): 4-6, 2010.
Abstracts (Past 3 Years)
  1. Stoddard D, Holena DN, Martin N, Winters B, Casey J, and Sarani B.   Preoperative Stabilization Of Closed Midshaft Femur Fractures: Do Traction Pins Reduce Transfusion Requirements Compared To Nonivasive Stabilization Methods? Poster presentation at 2011 EAST Conference, Jan 2011, Naples FLA
  2. Shashaty M,  Gallop R, Meyer N, Lanken P, Holena DN, Localio R, Bellamy S, Kaplan S, and Christie J.  Differences In Risk Factors For Acute Kidney Injury By Creatinine Versus Urine Output Criteria.  Poster Presentation Society of Critical Care Medicine 40th Critical Care Congress, Jan 2011, San Diego, CA
  3. Holena DN, Netzer G, Localio R,  Bellamy S, Gallop R, Meyer N, Shashaty M, Lanken P, and Christie J.  Time Dependency in the Association of Transfusion and Acute Lung Injury in the Injured Patient.  Poster Presentation Society of Critical Care Medicine 40th Critical Care Congress, Jan 2011, San Diego, CA
  4. Holena DN, Carr BG, Mills AM, Wirtalla C, and Kelz RR.   The Relationship Between Admission Source and In-hospital Mortality in Patients Undergoing Surgical Debridement for Necrotizing Fasciitis.  Podium Presentation Association of Academic Surgeons,  Jan 2011, Huntington Beach, CA
  5. Tolstoy N, Mills AM, Fox A, Levine J, and Holena DN.  Cooler heads prevail: A case of intractable intracranial hypertension after liver transplantation treated with therapeutic hypothermia. Poster Presentation Society of Critical Care Medicine 40th Critical Care Congress, Jan 2011, San Diego, CA
  6. Band R, Salhi R, Powell E, Holena DN, Branas C, and Carr BG.  Injury-adjusted Mortality of Patients Transported By Police Following Penetrating Trauma; The Philadelphia Experience.  Society of Academic Emergency Medicine June 2011, Boston, MA
  7. Mills AM, Holena DN, Kallan MJ, Carr BG, Reinke CE, and Kelz RR.  The Effect of Insurance Status on Patients Admitted for Acute Diverticulitis. Society of Academic Emergency Medicine June 2011, Boston, MA
  8. Brandon Bruns MD, Holena DN, Tolstoy N, HBal H BS, Holtz K, Reilly P, and Schwab CW.  A Distinct Lack of Contrast in Contrast-Induced Nephropathy.  Podium Presentation, 12th European Congress of Trauma & Emergency Surgery April 2011, Milan Italy
  9. Holena DN, Sims CA, Kim P, Sarani B, Pascual JL, Braslow B, Reilly PM, and Schwab CW. Trauma Bay Predictors of Mortality After Massive Transfusion Protocol Activation: A Ten Year Experience. Podium Presentation, 12th European Congress of Trauma & Emergency Surgery April 2011, Milan Italy
  10. McMonagle MP,  Guan Y, Tolstoy N, Holena DN, Kilty C, Keenan J, and  Sims C. Serum Alpha Glutathionine S-Transferase: A Novel Biomarker of Shock And Resuscitation.  Poster Presentation, 34th Annual Conference on Shock, June 2011, Norfolk, VA
  11. Skokan AJ, Villaroel JP, MD, Jeff Rohrbach J, Pisa M, Holena DN, Sonad SS, Sims CA End of Life and the Acute Care Surgeon: Untangling the Excessive Mortality in Emergency Palliative Care for Cancer Patients.  .  Podium Presentation at the Pennsylvania Committee on Trauma, Oct 2011, Harrisburg, PA
  12. Holena DN, Sims CA, Kim P, Sarani B, Pascual JL, Braslow B, Reilly PM, and Schwab CW. High Transfusion Ratios in Massive Transfusion : Decreased Mortality at the Cost of Increased Morbidity Podium Presentation, 97th Congress of the American College of Surgeons 2011, San Francisco CA
  13. Morris DM, Schweickert W, Handzel R, Holena DN, Sims CA, Pascual JP, Sarani B.  Is the Attending Physician Necessary at Rapid Response Activations? Poster Presentation Society of Critical Care Medicine 40th Critical Care Congress, Jan 2012, Dallas Tx
  14. Holena DN,  Sakran JV, Grabo DJ, Reinke CE, Mills AM, Sarani B, Sims CA, Pascual JL, Kelz RR.  Emergency General Surgery: Does An Individual Surgeon’s Volume Of Cases Matter?  Podium Presentation Association of Academic Surgeons,  Feb 2012, Las Vegas, NV
  15. Holena DN,  Reinke CE, Carr BG, Kelz RR. Risk Factors For Interhospital Transfer After Emergency Abdominal Surgery.  Podium Presentation Association of Academic Surgeons,  Feb 2012, Las Vegas, NV
  16. Massey PR, Sakran JV, Sarani B, Sims CA, Pascual JP, Holena DN.  Hyperbaric Oxygen Therapy In Patients With Necrotizing Soft Tissue Infections: No Impact On Mortality Or Amputation Rate Podium Presentation Association of Academic Surgeons,  Feb 2012, Las Vegas, NV
  17. Reinke CE, Nelson C, Holena DN,  Kann B, Williams N, Bleier J, Kelz RR.  A Novel Floor Management Simulation Course for Medical Students: Providing experience and feedback in a safe environment. Podium Presentation Association of Academic Surgeons,  Feb 2012, Las Vegas, NV
  18. Holena DN, Sims CA, Pascual JL, Reilly PM, and Schwab CW. Outcomes after Massive Transfusion are Equivalent to those after Supra-Massive TransfusionPodium Presentation, 13th European Congress of Trauma & Emergency Surgery April 2011, Basel Switzerland
  19. Shashaty M,  Gallop R, Meyer N, Lanken P, Holena DN, Localio R, Bellamy S, Kaplan S, and Christie J.  Genetically-determined African ancestry is associated with acute kidney injury in critically ill trauma patients.  Poster Presentation, American Thoracic Society May 2012, San Francisco, CA
  20. Reilly JP, Bellamy S,   Gallop R, Meyer N, Shashaty M, Lanken P, Holena DN, Reilly M , and Christie J.  Blood Group A and ABO Glycotransferase Genotype are Associated with Increased Risk of Acute Lung Injury after Blunt Trauma.  Poster Presentation, American Thoracic Society May 2012, San Francisco, CA
  21. Salhi RA, Band R, Reilly P, Holena DN, Branas C, and Carr BG.  Survival to Inclusion: Potential Biases in Evaluating Trauma Center Effectiveness Using Nationally Representative Data, Poster Presentation Society of Academic Emergency Medicine,  May 2012, Chicago IL
  22. Mills AM, Holena DN, Kerner C, Zafar H, Shofer FS, Baumann BM.  Electronic Accountability Tools Reduce CT Overutilization in ED Patients with Abdominal Pain. Poster Presentation Society of Academic Emergency Medicine,  May 2012, Chicago IL
  23. Li S, Marks J, Murcy M, Sanati P, Eisenstadt R, Gong W, Holena ND, Sims C, Smith D, Zhang J, Pascual, JP. Curcumin Reduces Microvascular Inflammation Following Traumatic Brain Injury - A Live Animal Study.  Presented, Neurotrauma 2012
  24. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA, Pascual JL, Reilly PM, Holena DN.  Interhospital Transfer: An Independent Risk Factor for Mortality in the Surgical Intensive Care Unit.  Podium Presentation, American College of Surgeons, October 2012, Chicago IL
  25. Gallesio JMA, Holena DN, Huang J, Sims CA, Levine J, Ying G,  Pascual JL.  HYPERTONIC Saline is Superior to Mannitol in Severe Traumatic Brain Injury for Hourly Correction Of ICP,
  26. and CPP but not Brain Oxygenation.  Poster Presentation, AAST 2012
  27. Isserman J, Lathma S, Tolstoy N, Greer S, Sonnad SS, Pascual JL, Holena DN, Sims CA.  Exception From Informed Consent for Emergency Research: Consulting The Trauma “Community”. Podium Presentation, American Association for the Society of Trauma, ST 2012
  28. Sonnenberg EM, Holena DN, Reinke CE, Meise CK, Mills AM, Karakousis GC, Kelz RR.  Fistula Formation following Bowel Surgery in Teaching Hospitals: A matched case-control study in a nationally representative cohort.  Podium Presentation, American College of Surgeons, October 2012, Chicago IL
  29. Polk TM, Sakran JV, Holena DN, Reilly PM.  Window Shopping Isn’t Always Free: The Hidden Cost of Diagnostic Pericardial Windows. Poster Presentation, AAST 2012
  30. Leary M, Holena DN, Neefe S, Davis L, Tsypenyuk B, Falk SA, Schweickert W.  A bundled approach to improving code team response for in-hospital cardiac arrest to decrease overcrowding and improve role clarity and leadership. AHA, Las Vegas NV, 2014.
  31. Folkert IW, Sims CA, Pascual JL, Allen SR, Kim PK, Schwab CW, Holena DN. Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study. European Congress for Trauma and Emergency Surgery, Frankfurt, Germany2014.
  32. Shashaty M, Mangalmurti N, Reilly JP, Sims CA, Holena CA, Lanken P, Christie JD.  Plasma Levels of the Essential Mediator of Necroptosis, Receptor Interacting Protein Kinase-3, Are Associated with Acute Kidney Injury in Critically Ill Trauma Patients.  ATA, Denver CO 2015.
  33. Hoffman RL, Saucier J, Ziemba J, Collins T, Holena DN, Reilly PM, Martin ND. A Focused, Time-sensitive, Multidisciplinary Critical Care Transition Protocol for High Risk Surgical Patients: A Quality Improvement Project.  SCCM, Phoenix AZ 2015.
  34. Pisa M, Collins T, Saucier J, Holena DN, Sicoutris C, Reilly P, Kohl B, Martin N. Stress (Subjective Transfer Risk Evaluation Severity Score) Accurately Predicts ICU Readmission. SCCM, Phoenix AZ 2015.
  35. Shashaty MG, Kalkan E, Bellamy S, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly PM, Udupa JK, Christie JD. Computed Tomography-Defined Abdominal Adiposity Is Associated With Acute Kidney Injury in Critically Ill Trauma Patients. SCCM, Phoenix AZ 2015.
  36. Shengjie L, Shengje Li, Marks JA, Eisenstadt R, Kumasaka K Samadi D, Johnson V, Holena DN, Allen SR, Browne K, Zhang J, Smith D, Pascual JL.  Enoxaparin Ameliorates Post-TBI Edema By Blunting Leukocyte Endothelial Interactions And Vessel Permeability In The Cerebral Circulation.  EAST, Orlando FL, 2015.
  37. Kuo LE, Karakousis GC, Simmons KD, Holena DN, Kelz RR.  Risk Prediction Model for Mortality in the Moribund Surgical Patient.  ASC, Las Vegas NV, 2015.
  38. Marks JA, Hatchimonji J, Kim P, Holena DN, Pascual JL, Reilly PM.  Concomitant Injuries In Patients With Devastating Head Injuries Do Not Preclude Organ Donation. ASC, Las Vegas NV, 2015.
  39. Allen SR, Cheney R, Ellis J, Holena DN, Pascual JL, Martin ND, Kim P, Reilly PM.  The Sixties: The Intersection of Modifiable Risks and Physical Vulnerability in Unintentional Falls. ASC, Las Vegas NV, 2015.
  40. Simmons KD, Kuo LE, Hoffman RL, Bartlett EK, Holena DN, Kelz RR.  Methodological Considerations in Outcomes Research: Timing of Surgery. ASC, Las Vegas NV, 2015.
  41. Simmons KD, Hoffman RL, Kuo LE, Bartlett EK, Holena DN, Kelz RR.  Is a Colectomy Always Just a Colectomy? Examining the Effect of Concurrent Procedures on Outcomes. ASC, Las Vegas NV, 2015.
  42.  Baehr A, Karp DN, Delgado MK, Holena DN, Wiebe DJ, Carr BG.  The Implications of Risk-Adjusting for Sociodemographic Factors in Assessing Emergency Care Survival in Pennsylvania.  Concordium 2015, Washington, DC. September 2015
  43. Holena DN, Agarwal A, Allen SR, Martin ND, Judd H, Chung J, Carr BG. The Use of TeleSurgical Consultation to Expand Access to Acute Surgical Care: A Pilot Trial of Feasibility.  American College of Emergency Physicians 2015 Research Forum.  Boston, MA. October 2015.
  44. Martin ND, Ramaswamy T, Marks J, Collins T, O'connor N, Casarett D, Holena DN, Pascual JL, Reilly PM, Kaplan L.  The Critical Illness Mortality Inflection Point During Prolonged Surgical ICU Length of Stay.  ACS, NSQIP Annual Scientific Meeting & Training.  Nashville, TN.  November 2015
  45. Holena, D.  The problem of Precedence: Examining the Composition of the Failure to Rescue Metric in Trauma.  29th EAST Annual Scientific Meeting.  San Antonio, TX. January 2016.
  46. Shashaty M, Reilly JP, Meyer N, Lanken P, Holena DN, Muredach R, Feldman H, Christie JD.  Just No ‘Resistin’ It:  Plasma resistin levels are associated with acute kidney injury in critically ill trauma patients.  Society of Critical Care Medicine.  (Submitted).
  47. Kaufman EJ, Holena DN.  Non-Operative Management of Splenic Injuries:  ICU Utilization and Mortality in a State Trauma System.  Academic Surgical Congress. (Submitted)
  48. Kuo L, Kaufman E, Pascual J, Reilly P, Martin N, Kim P, Holena DN.  Not all Failure-to-Rescue Events in Trauma are Preventable.  Academic Surgical Congress. (Submitted).
Editorials, Chapters, Participation in Committee Reports
(print or other media)
  1. Holena DN, Eachempati S, Barie P.  Biliary tract infections.  In Rello J, Kollef MH, Diaz E, Rodriguez A, eds.  Infectious Diseases in Critical Care, Second Edition.  Heidelberg: Springer-Verlag, 2007, 595-605.
  2. Holena DN, Gracias V, Hanson CW.   What is the role of the intensivist and ICU medical director?  In Deutschman C, Neligan P, eds. The Evidence-Based Practice of Critical Care.  Philadelphia:  Elsevier/WB Saunders, 2009, 673-680.
  3. Holena DN and Fox A.  Penetrating Peripheral Vascular Injury. In Moore EE, Rhee P,  Tisherman S, and Fulda G, eds.  Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers. Oxford: L John Wiley & Sons, Ltd. 2012, 302-310.
  4. Fox A and Holena DN.  Procedures in the ICU. In Moore EE, Rhee P, Tisherman S, and Fulda G, eds.  Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers.  Oxford: L John Wiley & Sons, Ltd. 2012, 233-242.
  5. Holena DN and Schwab CW.   Appendicitis.   In Peitzman AB, Rhodes M, Schwab CW. The Trauma Manual: Trauma and Acute Care Surgery. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2013, 624-630.
  6. Holena DN and Gracias V.  Hemorrhagic Shock.  In Lanken PN, Manaker S, Kohl BA, Hanson CW. Intensive Care Unit Manual: Expert Consult - Online and Print. Elsevier Science Health Science Division; 2013.
  7. Tariq N, Holena DN, Braslow B, and Kohl B.  Major Abdominal Surgery:Postoperative Consideration..  In Lanken PN, Manaker S, Kohl BA, Hanson CW. Intensive Care Unit Manual: Expert Consult - Online and Print. Elsevier Science Health Science Division; 2013.
  8. Hoffman R and Holena DN.  Surgical Infections Disease.  In Porrett, P. M., Roses, R. E., Frederick, J. R., et al. (2015). The Surgical Review: An Integrated Basic and Clinical Science Study Guide: Wolters Kluwer Health. 2015
 
Awards, Honors and Membership in Honorary Societies
2015 Patrick M. Reilly Trauma Teaching Award, Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2013 Nominee, Best Oral Presentation European Congress of Trauma and Emergency Surgery
Basel, Switzerland
 
2012 Nominee, Best Oral Presentation European Congress of Trauma and Emergency Surgery
Basel, Switzerland
 
2011 1st Prize - Best Oral Presentation European Congress of Trauma and Emergency Surgery
Milan, Italy
 
2010 Penn Undergraduate Research Mentorship Grant recipient
 
2008 Fellow Nominee, 15th Pulmonary and Critical Care ACCP Fellows Conference
Philadelphia, Pennsylvania
 
2007 Hassan Nama Resident Teaching Award, Weill-Cornell Medical School Department of Surgery
 
2002 Merck Manual Award, State University of New York at Stony Brook School of Medicine
 
2002 Student Commencement Speaker
State University of New York at Stony Brook School of Medicine
 
2001  Alpha Omega Alpha (Junior Inductee)
State University of New York at Stony Brook School of Medicine

Dr. Daniel Holena

 
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