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Daniel N. Holena, MD
Traumatology, Surgical Critical Care and Emergency Surgery

 
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Administrative Office:
Penn Presbyterian Medical Center
51 N. 39th Street
Medical Office Building, Suite 120
Philadelphia, PA 19104
Administrative Assistant: Andrea Brumbach
Administrative Telephone: 215-662-8886
Administrative Fax: 215-243-4679

Patient Appointments: 215-662-7320

Clinical Offices:
Hospital of the University of Pennsylvania
3400 Spruce Street, Maloney 5th Floor
Philadelphia, PA 19104

Perelman Center for Advanced Medicine
34th and Civic Center Boulevard
West Pavilion, 2nd and 4th Floors
Philadelphia, Pennsylvania, 19104

Penn Medicine at University City
3737 Market Street, 4th Floor
Philadelphia, Pennsylvania, 19104

Contact Information (internal use only)

daniel.holena@uphs.upenn.edu

 

Dr. Holena completed his surgical residency at New York Presbyterian Weill Cornell Medical Center in 2007 and subsequently completed a fellowship in Trauma and Surgical Critical Care at the Hospital of the University of Pennsylvania in 2009, after which he stayed on as an Assistant Professor of Surgery. Dr. Holena earned a Masters of Science in Clinical Epidemiology from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania while on an institutional K12 award through the National Heart, Blood, and Lung Institute and was subsequently awarded a K08 grant through the same institute.  His research efforts are focused on reducing mortality secondary to adverse events after injury (Failure to Rescue), interhospital transfer of trauma and emergency surgery patients, and the use of video review as a quality improvement tool in trauma resuscitation.

 

 
Faculty Appointments
2/2016 - present  Fellow, Institute on Aging
 
2013 - present Faculty, Center for Emergency Care Policy Research
 
2014 - present  Fellow, Penn Injury Science Center


2013 - present   Fellow, Leonard Davis Institute of Health Economics
 
2009 - present Assistant Professor of Surgery at HUP
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2007 - 2009  Instructor B in Surgery, University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2014 - present Fellow, Academic Support Staff, Penn Injury Science Center
 
2013 - present   Center for Emergency Care Policy Research, Faculty
 
2013 - present  Department of Surgery Representative, Telemedicine Committee
 
2012 - present   Member, ad hoc Code Improvement Committee
 
2011 - present   Member, Clinical Emergencies Committee
 
2011 - present   Director of Audiovisual Video Review, Division of Trauma
 
2011 - present Director of Surgical Rapid Response, Hospital of the University of Pennsylvania
 
2011 - present  Physician Leader, Unit Based Clinical Leadership Silverstein 12
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
 

2009 - present 

Attending Intensivist, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2008 - present  Attending Intensivist, Penn e-lert eICU, Pennsylvania Hospital
Philadelphia, Pennsylvania
 
2008 - present  Attending Trauma Physician, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2008 - 2009  Senior Administrative Fellow, Division of Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia,Pennsylvania
 
Editorial Positions
2011 - present Ad Hoc Reviewer, Injury
 
2011 - present Editor,  Journal of Trauma and Treatment
 
Education/Training
2013 - 2015 MSCE, Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
 
2013 - 2014 Penn Medicine Leadership Academy
 
2009 - 2011 Research Certificate, Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
 
1998 - 2002 MD - State University of New York at Stony Brook
Stony Brook, New York
 
1991 - 1995 BSc - McGill University (Biology)
Montreal, Canada


Postgraduate Training and Fellowship Appointments
2015 - present Senior Fellow, Leonard Davis Institute of Health Economics
University of Pennsylvania, Philadelphia, Pennsylvania
 
2007 - 2009 Fellowship in Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2003 - 2007 Resident in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
 
2002 - 2007 Rotating Resident in Surgical Oncology
Memorial Sloan-Kettering Cancer Center
New York, New York
 
2002 - 2003 Internship in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
 
Other Appointments
1998 - 2001 Student Representative, Class of 2002
State University of New York at Stony Brook School of Medicine
Stony Brook, New York
 
2008 - 2009 Instructor B in Surgery
University of Pennsylvania School of
 
Memberships/Societies
 
National/International Societies
  Eastern Association for the Surgery of Trauma
Research and Scholarship Committee
 
 

Society of Critical Care Medicine
Surgical Section

 
  American College of Surgeons (Fellow)
 
  American Medical Association
 
  Association of Academic Surgeons
Outcomes Research Committee
 
 

European Society for Trauma and Emergency Surgery
Visceral Trauma Section

 
  American Association for the Surgery of Trauma
 
Local/Regional Societies
  Pennsylvania Medical Society
 
 

American College of Surgeons, Philadelphia Chapter

 
Scientific Committees
  Patient Centered Outcomes Research Institute, Merit Reviewer
 
  National Institutes of Health, Early Career Reviewer Program
 
  Thoracic and Lumbar Spine Practice Management Guideline Committee
Eastern Association for the Surgery of Trauma
 
Research
Research Funding
2015 - 2018

NHLBI, K08HL131995, “Reducing Mortality Attributable to Cardiac And Pulmonary Complications after Traumatic Injury: Understanding the Role of Failure-to-Rescue.”
Role: PI

 
2015 - 2020 National Heart, Lung, And Blood Institute/Nih/Dhhs, “The Role Of Abo Glycosyltransferases In The Acute Respiratory Distress Syndrome” Role: Co PI
 
2015 - 2016 Penn Injury Science Center Pilot Grant“Patient experiences of Trauma Resuscitations”   Role: PI
 
2015 - 2016 Laerdral Corporation “An innovative leadership dyad for in-hospital cardiac arrest to improve code team process variables and clinical outcomes”.   Role: Co-I
 
2013 - 2015 NHLBI   K-12 Scholarship (K12 HL 109009)
 
2014 - 2014   Leonard Davis Institute High Risk/Innovation Grant
 
2013 - 2014  CTSA/CCEB -2014 PCOR Pilot Grant 
 
Publications
 
Research Publications, Peer Reviewed
  1. Pieracci FM, Henderson P, Rodney JR, Holena DN, Genisca A, Benkert S, Hydo LJ, Eachempati SR, Shou J, Barie PS. Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anemia and risk of infection during surgical critical illness. Surgical Infections. 10(1):9-19. Feb 2009. PMID:19245362
  2. Holena DN, Hadler R, Wirtalla C, Carr B, Morris JB, Kelz RR. Teaching status: The impact on emergency and elective surgical care in the US. Annals of Surgery 2011;253:1017-23. PMID: 21451392
  3. Holena DN, Mills AM, Carr BG, Wirtalla C, Sarani B, Kim PK, Braslow BM, Kelz RR. Transfer Status: A risk factor for mortality in patients with necrotizing fasciitis. Surgery 2011;150:363-70. PMID : 21783216
  4. Mills AM, Edwards JM, Shofer FS, Holena DN, Abbuhl SB. Analgesia for older adults with abdominal or back pain in the emergency department. Western Journal of Emergency Medicine 2011;12:43-50. PMID: 21691471
  5. Mills AM, Shofer FS, Boulis AK, Holena DN, Abbuhl SB. Racial disparity in analgesic treatment for ED patients with abdominal or back pain. American Journal of Emergency Medicine 2011;29:752-6. PMID: 20825892
  6. Pascual JL, Holena DN, Vella MA, Palmieri J, Sicoutris C, Selvan B, Fox AD, Sarani B, Sims C, Williams NN, Schwab CW. Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit. Journal of Trauma - Injury, Infection and Critical Care 2011;71:330 PMID: 21825935
  7. Holena D, Stoddard D, Martin ND, Winters B, Casey J, Pascual J, Sims C, Sarani B. Clinical outcomes following invasive versus noninvasive preoperative stabilization of closed diaphyseal femur fractures. European Journal of Trauma and Emergency Surgery 2012 Dec; 38(6):623-6. PMID: 26814547
  8. Holena DN, Netzer G, Localio R, Gallop RJ, Bellamy SL, Meyer NJ, Shashaty MGS, Lanken PN, Kaplan S, Reilly PM, Christie JD. The association of early transfusion with acute lung injury in patients with severe injury. Journal of Trauma and Acute Care Surgery 2012;73:825-31. PMID : 23014528
  9. Holena DN, Tolstoy N, Mills AM, Fox A, and Levine J.  Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation.  Am J Crit Care 21 (1): 72-75, 2012 Jan. PMID: 22210703
  10. Massey PR, Sakran JV, Mills AM, Sarani B, Aufhauser Jr DD, Sims CA, Pascual JL, Kelz RR, Holena DN. Hyperbaric oxygen therapy in necrotizing soft tissue infections. Journal of Surgical Research 2012;177:146-51. PMID: 22487383
  11. Mollo EA, Reinke CE, Nelson C, Holena DN, Kann B, Williams N, Bleier J, Kelz RR. The simulated ward: Ideal for training clinical clerks in an era of patient safety. Journal of Surgical Research 2012;177:E1-E6. PMID: 22524978
  12. Sakran JV, Holena DN, and Dickinson E.  Collaboration makes survival possible for thoracic injury patient.  Journal of Emergency Medical Services 33(8):28-31, March. 2012.     PMID: 22734270
  13. Morris DS, Schweickert W, Holena D, Handzel R, Sims C, Pascual JL, Sarani B. Differences in outcomes between ICU attending and senior resident physician led medical emergency team responses. Resuscitation 2012;83:1434-7.  PMID: 22841611
  14. Shashaty MGS, Meyer NJ, Localio AR, Gallop R., BellamySL, Holena DN, Lanken PN, Kaplan S, Yarar D, Kawut SM, Feldman HI, Christie JD.  African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients.  Journal of Critical Care 27 (5), pp. 496-504 PMID : 22591570
  15. Sixta S, Moore FO, Ditillo MF, Fox AD, Garcia AJ, Holena D, Joseph B, Tyrie L, Cotton B. Screening for thoracolumbar spinal injuries in blunt trauma: An Eastern Association for the Surgery of Trauma practice management guideline. Journal of Trauma and Acute Care Surgery 2012;73:S326-S32. PMID : 23114489
  16. Gallesio JMA, Holena DN, Huang J, Sims C, Levine J, Ying GS et al. Erratum: Hypertonic saline is superior to mannitol in severe traumatic brain injury for hourly correction of intracranial pressure and cerebral perfusion pressure and brain oxygenation (Journal of the American College of Surgeons 215 (S54)). Journal of the American College of Surgeons. 2013;216(1):176.
  17. Georgoff P, Perales P, Laguna B, Holena D, Reilly P, Sims C. Colonic injuries and the damage control abdomen: Does management strategy matter? Journal of Surgical Research. 2013;181(2):293-9. PMID: 22884449
  18. Johnson NJ, Carr BG, Salhi R, Holena DN, Wolff C, Band RA. Characteristics and outcomes of injured patients presenting by private vehicle in a state trauma system. American Journal of Emergency Medicine 2013;31:275-81. PMID : 23000329
  19. Mills AM, Holena DN, Kallan MJ, Carr BG, Reinke CE, Kelz RR. Effect of insurance status on patients admitted for acute diverticulitis. Colorectal Disease. 2013;15(5):613-20. PMID: 23078007
  20. Sensenig RL, Tolstoy NS, Holena DN. A spontaneously expelled bullet from the urethra: A case of undetected bladder injury after abdominal gunshot wound. Injury Extra. 2013;44(6):58-9..
  21. Sims CA, Isserman JA, Holena D, Sundaram LM, Tolstoy N, Greer S, Sonnad S, Pascual J, Reilly P. Exception from informed consent for emergency research: Consulting the trauma community. Journal of Trauma and Acute Care Surgery 2013;74:157-66. PMID : 23271091
  22. Johnson NJ, Carr BG, Salhi R, Holena DN, Wolff C, Band RA: Characteristics and outcomes of injured patients presenting by private vehicle in a state trauma system. Journal of Emergency Medicine 31(2): 275-81, February 2013. PMID:23000329
  23. Tolstoy NS, Aized M, McMonagle MP, Holena DN, Pascual JL, Sonnad SS et al. Mineralocorticoid deficiency in hemorrhagic shock. Journal of Surgical Research. 2013;180(2):232-7. PMID: 22683082
  24. Georgoff Patrick, Perales Paul, Laguna Benjamin, Holena DN, Reilly Patrick, Sims Carrie: Colonic injuries and the damage control abdomen: does management strategy matter? The Journal of surgical research 181(2): 293-9, May 2013. PMCID: PMC3743720
  25. Jacovides CL, Bruns B, Holena DN, Sims CA, Wiebe DJ, Reilly PM et al. Penetrating trauma in urban women: Patterns of injury and violence. Journal of Surgical Research. 2013;184(1):592-8. PMID :23890398
  26. Ebbeling L, Grabo DJ, Shashaty M, Dua R, Sonnad SS, Sims CA et al and Holena DN. Psoas: Lumbar Vertebra Index: Central Sarcopenia Independently Predicts Morbidity in Elderly Trauma Patients. European Journal of Trauma and Emergency Surgery. 2013:1-9. PMID: 26815778
  27. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA et al and Holena DN Interhospital transfer: An independent risk factor for mortality in the surgical intensive care unit. American Surgeon. 2013;79(9):909-13 PMID: 24069990
  28. Davis L,  Johnson L, Allen SR., Kim PK., Sims CA, Pascual JL, Holena, DN.  Practitioner Perceptions of Trauma Video Review.  Journal of Trauma Nursing. 2013;(3) :150-154 PMID : 24005118
  29. Band RA, Salhi RA, Holena DN, Powell E, Branas CC, Carr BG. Severity-Adjusted Mortality in Trauma Patients Transported by Police. Annals of Emergency Medicine. 63(5):608-614.e3, 2014, May. PMID: 24387925
  30. Bruns BR, DuBose J, Pasley J, Kheirbek T, Chouliaras K, Riggle A, Frank MK, Phelan HA, Holena D, Inaba K, et al. Loop versus end colostomy reversal: has anything changed? European Journal of Trauma and Emergency Surgery. 2014. PMID: 26037983
  31. Reilly JP, Meyer NJ, Shashaty MG, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena DN, Reilly MP, Christie JD. ABO Blood Type A is Associated with Increased Risk of Acute Respiratory Distress Syndrome in Caucasians Following both Major Trauma and Severe Sepsis. Chest. 145(4):753-61, 2014, April. PMID: 24385226
  32. Pascual JL, Blank NW, Holena DN, Robertson MP, Diop M, Allen SR, Martin ND, Kohl BA, Sims CA, Schwab CW, Reilly PM. There's no place like home: Boarding surgical ICU patients in other ICUs and the effect of distances from the home unit Journal of Trauma Acute Care Surg. 76(4):1096-102, 2014 April.  PMID:24662877
  33. Sonnenberg EM, Reinke CE, Bartlett EK, Collier KT, Karakousis GC, Holena DN, Kelz RR. Wind, water, wound, walk - Do the data deliver the dictum? Journal of Surgical Education. 2014;72(1):164-169.  PMID: 25131719
  34. Shashaty MGS, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD. Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically Ill trauma patients. Critical Care Medicine. 2014;42(7):1619-1628.  PMID:24776609
  35. Reilly JP, Bellamy S, Shashaty MGS, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD. Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Annals of the American Thoracic Society. 2014;11(5):728-736.  PMID: 4225810
  36. Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Critical Care Medicine. 2014;42(9):2048-2057. PMID: 24797376
  37. Kim L, Schuster J, Holena DN, Sims C, Levine J, Pascual J. Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on brain imaging. Journal of Emergencies, Trauma and Shock. 2014;7(3):141-148. PMID: 25114421
  38. Vioque SM, Kim PK, McMaster J, Gallagher J, Allen SR, Holena DN, Reilly, PM, Pascual JL.  Classifying errors in preventable and potentially preventable trauma deaths:  a 9 year review using the Joint Commission’s standardized methodology.  Am Journal of Surgery 208(2):187-97, 2014 August. PMID: 24814306
  39. Kuo LE, Simmons KD, Holena DN, Karakousis G, Kelz RR. A risk prediction model for mortality in the moribund general surgical patient. J Crit Care. 2015;30(2):310-314.  PMID: 25499416
  40. Barry ME, Hochman, B. R.,  Lane-Fall, M. B.,  Zappile, D. M.,  Holena, D. N.,  Allen S.R.,  Martin, N. D.,  Reilly, P. M.,  Pascual, J. L.: Operating Room-to-ICU Handoffs Captured on Video: Are Transitions at Night More Dangerous? Journal of the American College of Surgeons 221(4): S43-S43, 2015
  41. Folkert IW, Sims CA, Pascual JL, Allen SR, Kim PK, Schwab CW, Holena DN. Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study. European Journal of Trauma and Emergency Surgery. April 2015; 41(2):203-9. PMID: 26038266
  42. Allen SR, Scantling DR, Delgado MK, Mancini J, Holena DN, Kim P, Pascual JL, Reilly P. Penetrating torso injuries in older adults: increased mortality likely due to “failure to rescue”. European Journal of Trauma and Emergency Surgery. December 2015;41(6):657-63. PMID: 26038012
  43. Jacovides CL, Nadolski G, Allen SR, Martin ND, Holena DN, Reilly PM, Trerotola S, Braslow BM, Kaplan LJ, Pascual JL.  Arteriography for lower gastrointestinal hemorrhage role of preceding abdominal computed tomographic angiogram in diagnosis and localization.  JAMA Surgery, 150(7):650-656. July 2015. PMID: 25992504
  44. Simmons KD, Hoffman RL, Kuo LE, Bartlett EK, Holena DN, Kelz RR. Is a Colectomy Always Just a Colectomy? Additional Procedures as a Proxy for Operative Complexity. Journal of the American College of Surgeons. 2015 Oct; 221(4):862-70. PIMD: 26228014
  45. Li S, Marks JA, Eisenstadt R, Kumasaka K, Samadi D, Johnson VE, Holena DN, Allen SR, Browne KD, Smith DH, Pascual JL. Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo. Journal of Trauma and Acute Care Surgery. 2015;79(1):78-84. PMID: 26091318
  46. Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MG. The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis. Clinical journal of the American Society of Nephrology : CJASN. 2015 Nov 6. PMID: 26342043
  47. Saillant NN, Earl-Royal E, Pascual JL, Allen SR, Kim PK, Delgado MK, Carr BG, Wiebe D, Holena DN. The Relationship between processes and outcomes for injured older adults: a study of a statewide trauma system. European Journal of Trauma and Emergency Surgery. 2015 Oct 25. PMID: 26510941
  48. Pascual JL, Hochman BR, Barry ME, Lane-Fall MB, Allen SR, Holena DN, Kaplan LJ, Smith BP: Handoffs in the Intensive Care Unit: Are Off Hours a Vulnerable Time. American Journal of Medical Quality December 2015. PMCID: AJMQ-15-201
  49. Holena DN, Earl-Royal E, Delgado MK, Sims CA, Pascual JL, Hsu JY, Carr BG, Reilly PM, Wiebe D. Failure to Rescue In Trauma: Coming to Terms with the Second Term. Injury. 47 (1) pp. 77-82. January 2016. PMID: 26510941
  50. Shashaty MG, Reilly JP, Sims CA, Holena DN, Qing D, Forker CM, Hotz MJ, Meyer NJ, Lanken PN Feldman HI, Christie JD, Mangalmurti NS. Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients. Shock. 2016 Feb 24. PMID:26925809.
  51. Kaufman EJ, Wiebe DJ, Martin ND, Pascual JL, Reilly PM, Holena DN. Variation in Intensive Care Unit Utilization and Mortality After Blunt Splenic Injury. Journal of Surgical Research. 203 (2) pp. 338-347. June 15, 2016. PMID: 27363642
  52. Collins TA, Robertson MP, Sicoutris CP, Pisa MA, Holena DN, Reilly PM, Kohl BA. Telemedicine Coverage for Post-Operative ICU Patients. Journal of Telemedicine and Telecare. June 30, 2016. PMID: 27365321
  53. Leary M, Schweickert W, Neefe S, Tsypenyuk B, Falk SA, Holena DN. Improving Providers’ Role Definitions to Decrease Overcrowding and Improve In-Hospital Cardiac Arrest Response. American Journal of Critical Care. 25(4): 335-9. July 2016. PMID: 27369032
  54. Wiebe DJ, Holena DN, Delgado MK, Geiger J, McWilliams N, Carr BG. The Pennsylvania Trauma Outcomes Study Risk-Adjusted Mortality Model: Results of a Statewide Benchmarking Program. The American Surgeon. (Accepted)
  55. Holena DN, Kaufman E. Risk Factors for Severe Adverse Events and Failure to Rescue After Injury. Journal of Surgical Research. (Accepted)
Reviews in Peer Reviewed Research Publications
(print or other media)
  1. Allen S, Holena D, McCunn M, Kohl B, Sarani B. A review of the fundamental principles and evidence base in the use of Extracorporeal Membrane Oxygenation (ECMO) in critically Ill adult patients. Journal of Intensive Care Medicine 2011;26:13-26.
  2. Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Critical Care Medicine. 2014;42(9):2048-2057. PMID: 24797376
Contributions to Peer-Reviewed Clinical Research Publications, Participation Cited but not by Authorship
  1. Lemos-Filho LB, Mikkelsen ME, Martin GS, Dabbagh O, Adesanya A, Gentile N, Esper A, Gajic O, Gong MN. Sex, Race, and the Development of Acute Lung Injury.Chest 143 (4) 901-909, 2012. PMID: 23117155
Research Publications, Non-Peer Reviewed
  1. Weinberger LN, Holena DN, Powell EK, Gracias V.  Arc determination equals injury identification: Trauma mantra applied to electrocution. Injury Extra 39:389-391, 2008.
  2. Holena DN, Perman S, Hankin A, and Schwab CW.  An unusual cause of airway obstruction.   Injury Extra 40 (9): 168-169, 2009.
  3. Holena DN and Braslow B.  Cecal bleeding as a complication of conservative management of acute colonic pseudo-obstruction.  Internet Journal of Emergency Medicine.  5(2):  2009.
  4. Pascual JL, Holena DN, Del Portal D, and Schwab CW.  Blunt intrapericardial superior vena cava injury: a trap for the unwary. Injury Extra 41 (1): 4-6, 2010.
  5. Tolstoy N, Mills, A.,  Fox, A.,  Levine, J.,  Holena, D.: Cooler Heads Prevail: A Case of Intractable Intracranial Hypertension after Liver Transplantation Treated with Therapeutic Hypothermia. Critical Care Medicine 38(12): U298-U298, 2010.
  6. Holena DN, Tolstoy Nikolai S, Mills Angela M, Fox Adam D, Levine Joshua M: Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation. American journal of critical care : an official publication, American Association of Critical-Care Nurses 21(1): 72-5, Jan 2012.
  7. Sakran Joseph V, Holena Daniel, Reilly Patrick M, Dickinson Edward T: Team effort: collaboration makes survival possible for thoracic injury patient. JEMS : a journal of emergency medical services 37(3): 28, 31, Mar 2012.
  8. Sensenig RL, Tolstoy NS, Holena DN: A spontaneously expelled bullet from the urethra: A case of undetected bladder injury after abdominal gunshot wound. Injury Extra 2013.
  9. Hoffman R and Holena DN. : Surgical Infections. Wolters Kluwer Health 2015.
Abstracts (Past 3 Years)
  1. Ebbeling L, Grabo D, Sims CA, Dua R, Pascual JL,  Schwab CW, and  Holena DN. Psoas: Lumbar Vertebra Index: Central Sarcopenia Independently Predicts Morbidity in Elderly Trauma Patients. Podium Presentation, 13th European Congress of Trauma & Emergency Surgery April 2013, Lyon France
  2. Collins T, Pisa M, Kohl B, Holena DN, Reilly PMR Telemedicine Coverage Can Safely Provide Virtual ICU Beds.  Society of Critical Care Medicine, 2013 Puerto Rico.
  3. Eisenstadt R , Sensenig RL, Holena DN, Sims CA, Braslow B , Pascual JL : Dislodged Surgical Feeding Tubes: Should We Abandon Bedside Contrast Abdominal KUB's In Favor Of CT Podium Presentation American Surgical Conference New Orleans, 2013
  4. Martin N, Chreiman K, Patel S, Weber M, Kheirbek T, Pascual J, Holena DN, Reilly PM. ICU Bedside Abdominal Exploration for Patients in Extremis: Reasonable Care or Surgical Futility   SCCM, San Francisco CA, 2014
  5. Shashaty M, Hiciano I, Bellamy S, Holena DN, Reilly J, Lanken P, Feldman H, Christie J. Risk Factors Differ For Creatinine- Versus Urine Output-Defined Acute Kidney Injury. SCCM, San Francisco CA, 2014
  6. Pascual J, Blank N, Diop M, Holena DN, Robertson M, Collins T, Allen S. Trauma Patients Readmitted to the Surgical ICU Have High Rates of Post-Admission Complications. SCCM, San Francisco CA, 2014.
  7. Martin ND, Ramagnano S, Boris Tsypenyuk B, Collins T,  Pascual JL, Holena DN,  Allen SR,  Sims CA,  Reilly PM, Kohl B.  Family & Loved Ones Satisfaction in the Intensive Care Setting: New focus for Patient-centered Care SCCM, San Francisco CA, 2014
  8. Pascual J, Allen S, Bridges A, Weibe D, Holena D, Sims C, Schwab C, Reilly P. 259: Humidity Is More Important Than Temperature In Predicting Summer Penetrating Urban Trauma Incidence. SCCM, San Francisco CA, 2014
  9.  Bruns BR, J. DuBose J,  Pasley J, Kheirbek T, Chouliaras K, Riggle A, Frank M, Phelan H, Holena DN,  Inaba K,  Diaz J, ScaleaTM.   Morbidity After Loop Versus End Colostomy Reversal: Has Anything Changed? ASC, San Diego CA, 2014
  10. Diop M, Holena DN, Blank N, Roberston M, Collins T, Allen SR, Martin N, Sims CA, Pascual JL The Next Shoe to Drop: Trauma Patients Readmitted to the Surgical ICU Have High Rates of Post-Admission Complications. ASC, San Diego CA, 2014
  11. Sonnenberg EM, Reinke CE, Bartlet EK, Collier KT, Karakousis GC, Holena DN, Kelz Wind, Water Wound, Walk – Does the Data Deliver the Dictum?  ASC, San Diego CA, 2014.
  12. Leary M, Holena DN, Neefe S, Davis L, Tsypenyuk B, Falk SA, Schweickert W.  A bundled approach to improving code team response for in-hospital cardiac arrest to decrease overcrowding and improve role clarity and leadership. AHA, Las Vegas NV, 2014.
  13. Folkert IW, Sims CA, Pascual JL, Allen SR, Kim PK, Schwab CW, Holena DN. Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study. European Congress for Trauma and Emergency Surgery, Frankfurt, Germany2014.
  14. Shashaty M, Mangalmurti N, Reilly JP, Sims CA, Holena DN, CA, Lanken P, Christie JD.  Plasma Levels of the Essential Mediator of Necroptosis, Receptor Interacting Protein Kinase-3, Are Associated with Acute Kidney Injury in Critically Ill Trauma Patients.  ATA, Denver CO 2015.
  15. Hoffman RL, Saucier J, Ziemba J, Collins T, Holena DN, Reilly PM, Martin ND. A Focused, Time-sensitive, Multidisciplinary Critical Care Transition Protocol for High Risk Surgical Patients: A Quality Improvement Project.  SCCM, Phoenix AZ 2015.
  16. Pisa M, Collins T, Saucier J, Holena DN, Sicoutris C, Reilly P, Kohl B, Martin N. Stress (Subjective Transfer Risk Evaluation Severity Score) Accurately Predicts ICU Readmission. SCCM, Phoenix AZ 2015.
  17. Shashaty MG, Kalkan E, Bellamy S, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly PM, Udupa JK, Christie JD. Computed Tomography-Defined Abdominal Adiposity Is Associated With Acute Kidney Injury in Critically Ill Trauma Patients. SCCM, Phoenix AZ 2015.
  18. Shengjie L, Shengje Li, Marks JA, Eisenstadt R, Kumasaka K Samadi D, Johnson V, Holena DN, Allen SR, Browne K, Zhang J, Smith D, Pascual JL.  Enoxaparin Ameliorates Post-TBI Edema By Blunting Leukocyte Endothelial Interactions And Vessel Permeability In The Cerebral Circulation.  EAST, Orlando FL, 2015.
  19. Kuo LE, Karakousis GC, Simmons KD, Holena DN, Kelz RR.  Risk Prediction Model for Mortality in the Moribund Surgical Patient.  ASC, Las Vegas NV, 2015.
  20. Marks JA, Hatchimonji J, Kim P, Holena DN, Pascual JL, Reilly PM.  Concomitant Injuries In Patients With Devastating Head Injuries Do Not Preclude Organ Donation. ASC, Las Vegas NV, 2015.
  21. Allen SR, Cheney R, Ellis J, Holena DN, Pascual JL, Martin ND, Kim P, Reilly PM.  The Sixties: The Intersection of Modifiable Risks and Physical Vulnerability in Unintentional Falls. ASC, Las Vegas NV, 2015.
  22. Simmons KD, Kuo LE, Hoffman RL, Bartlett EK, Holena DN, Kelz RR.  Methodological Considerations in Outcomes Research: Timing of Surgery. ASC, Las Vegas NV, 2015.
  23. Simmons KD, Hoffman RL, Kuo LE, Bartlett EK, Holena DN, Kelz RR.  Is a Colectomy Always Just a Colectomy? Examining the Effect of Concurrent Procedures on Outcomes. ASC, Las Vegas NV, 2015.
  24.  Baehr A, Karp DN, Delgado MK, Holena DN, Wiebe DJ, Carr BG.  The Implications of Risk-Adjusting for Sociodemographic Factors in Assessing Emergency Care Survival in Pennsylvania.  Concordium 2015, Washington, DC. September 2015
  25. Holena DN, Agarwal A, Allen SR, Martin ND, Judd H, Chung J, Carr BG. The Use of TeleSurgical Consultation to Expand Access to Acute Surgical Care: A Pilot Trial of Feasibility.  American College of Emergency Physicians 2015 Research Forum.  Boston, MA. October 2015.
  26. Martin ND, Ramaswamy T, Marks J, Collins T, O'connor N, Casarett D, Holena DN, Pascual JL, Reilly PM, Kaplan L.  The Critical Illness Mortality Inflection Point During Prolonged Surgical ICU Length of Stay.  ACS, NSQIP Annual Scientific Meeting & Training.  Nashville, TN.  November 2015
  27. Chung JC, Earl-Royal E, Delgado MK, Pascual JL, Sims CA,  Wiebe DJ, Reilly PM,  and Holena DN. Where We Fail: The Location and Timing of Failure To Rescue Events In Trauma. AAST, Las Vegas NV, 2015.
  28. Saillant NN, Earl-Royal E, Pascual JL, Allen SR, Kim PK, Delgado MK, Carr BG, Weibe DJ, Holena DN.  The Relationship Between Processes and Outcomes for Injured Older Adults: A Study of a Statewide Trauma System.  AAST, Las Vegas NV, 2015.
  29. Holena DN, Carr BG, Wiebe DJ, Christie JC Reilly PM.  The problem of Precedence: Examining the Composition of the Failure to Rescue Metric in Trauma.  29th EAST Annual Scientific Meeting.  San Antonio, TX. January 2016.
  30. Shashaty M, Reilly JP, Meyer N, Lanken P, Holena DN, Muredach R, Feldman H, Christie JD.  Just No ‘Resistin’ It:  Plasma resistin levels are associated with acute kidney injury in critically ill trauma patients.  Society of Critical Care Medicine.  2015.
  31. Shashaty M, Mangalmurti N, Reilly JP, Sims CA, Holena DN, Lanken P, Christie JD. : Plasma Levels of the Essential Mediator of Necroptosis, Receptor Interacting Protein Kinase-3, Are Associated with Acute Kidney Injury in Critically Ill Trauma Patients.   ATA 2015
  32. Kuo LE, Karakousis GC, Simmons KD, Holena DN, Kelz RR: Risk Prediction Model for Mortality in the Moribund Surgical Patient.  ASC 2015.
  33. Simmons KD,Hoffman RL,  Kuo LE, Bartlett EK, Holena DN, Kelz RR: Is a Colectomy Always Just a Colectomy? Examining the Effect of Concurrent Procedures on Outcomes.  ASC 2015.
  34. Simmons KD, Kuo LE, Hoffman RL, Bartlett EK, Holena DN, Kelz RR.: Methodological Considerations in Outcomes Research: Timing of Surgery. ASC 2015.
  35. Hersperger S, Becker A, Heiderich G, Smith BP, Holena DN, Schutz A, Mancini JD, Kumar N, Mook M, Holland S, Motuk G, Martin N, Reilly PM, Kim PK, Pascual JL. Becoming a Trauma Center Overnight: Using Simulation to Train Seasoned Yet Trauma-Naïve Providers Prior to Becoming Trauma Providers. PSTF/PACOT Meeting. Harrisburg, PA. October 23, 2015.
  36. Martin ND, Patel SP, Chreiman K, Pascual JL, Holena DN, Braslow BM, Reilly PM, Kaplan L. Surgery for Patients in Extremis: Reasonable Care or Surgical Futility? 11th Annual Academic Surgical Congress. Jacksonville, FL. February 2, 2016.
  37. Asfaw SH, Martin ND, Seamon MJ, Pascual JL, Sims CA, Reilly PM, Holena DN. Is it Cool to Cool Post Cardiac Arrest Trauma Patients? 11th Annual Academic Surgical Congress. Jacksonville, FL. February 2, 2016.
  38. Kuo L, Kaufman E, Pascual JL, Reilly PM, Martin ND, Kim PK, Holena DN. Not All Failure-to-Rescue Events in Trauma are Preventable. 11th Annual Academic Surgical Congress. Jacksonville, FL. February 2, 2016.
  39. Kaufman EJ, Holena DN. Non-Operative Management of Splenic Injuries: ICU Utilization and Mortality in a State Trauma System. 11th Annual Academic Surgical Congress. Jacksonville, FL. February 2, 2016.
  40. Holena DN. Go With your First Impression: Trauma Center Admission Vital Signs Underpredict Mortality in Transferred Trauma Patients. Science of Safety for Our Cities Conference. April 14, 2016.
  41. Holena DN, Wiebe DJ, Carr BG, Hsu JY, Sperry JL, Peitzman AB, Reilly PM. “The Impact of Lead-time Bias in Benchmarking Trauma Outcomes.” Science of Safety for our Cities. Philadelphia, PA. April 14, 2016.
  42. Holena DN, Kaufman EK, Wiebe DJ, Carr BG, Reilly MD. “A Metric of Our Own: Failure to Rescue in Trauma.” Emergency Medicine Day of Research. Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA. April 14, 2016.
  43. Delgado MK, Nova J, Holena DN, Carr B, Neuman M, Small D, DeLia D. “Validation of Travel Distance as an Instrumental Variable for Evaluating the Effectiveness of Regionalized Trauma Care.” Research Symposium. Penn Institute on Aging. June 8, 2016.
  44. Cannon JW, Seamon MJ, Smith BP, Kaplan L, Holena DN, Reilly PM. “Resuscitation Hypocalcemia and Over-Correction Should Be Avoided in Severely Injured Patients.” 75th Annual Meeting of AAST. Waikoloa, HI. September 14, 2016. 
  45. Kaufman EJ, Holena DN, Wiebe DJ, Terry R. “Patient Experiences of Trauma Resuscitation.” American College of Surgeons 2016 Clinical Congress. Washington, DC. October 16, 2016.
  46. Holena DN, Kaufman EJ. Go With Your First Impression: Trauma Center Admission Vital Signs Underpredict Mortality in Transferred Trauma Patients. American College of Surgeons 2016 Clinical Congress. Washington, DC. October 16, 2016.
  47. Pascual JL, Holena DN, Abel-Baker P, Motuk G, McMaster J, Kim PK, Mook MM, Holland S, Huffenberger A. “Gauging Trauma Center Quality Improvement by Classifying Adverse Events from Recurring in Situ Simulations Using the JC Taxonomy.” American College of Surgeons Clinical Congress. Washington, DC. October 16, 2016.
Editorials, Chapters, Participation in Committee Reports
(print or other media)
  1. Holena DN, Eachempati S, Barie P.  Biliary tract infections.  In Rello J, Kollef MH, Diaz E, Rodriguez A, eds.  Infectious Diseases in Critical Care, Second Edition.  Heidelberg: Springer-Verlag, 2007, 595-605.
  2. Holena DN, Gracias V, Hanson CW.   What is the role of the intensivist and ICU medical director?  In Deutschman C, Neligan P, eds. The Evidence-Based Practice of Critical Care.  Philadelphia:  Elsevier/WB Saunders, 2009, 673-680.
  3. Holena DN and Fox A.  Penetrating Peripheral Vascular Injury. In Moore EE, Rhee P,  Tisherman S, and Fulda G, eds.  Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers. Oxford: L John Wiley & Sons, Ltd. 2012, 302-310.
  4. Fox A and Holena DN.  Procedures in the ICU. In Moore EE, Rhee P, Tisherman S, and Fulda G, eds.  Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers.  Oxford: L John Wiley & Sons, Ltd. 2012, 233-242.
  5. Holena DN and Schwab CW.   Appendicitis.   In Peitzman AB, Rhodes M, Schwab CW. The Trauma Manual: Trauma and Acute Care Surgery. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2013, 624-630.
  6. Holena DN and Gracias V.  Hemorrhagic Shock.  In Lanken PN, Manaker S, Kohl BA, Hanson CW. Intensive Care Unit Manual: Expert Consult - Online and Print. Elsevier Science Health Science Division; 2013.
  7. Tariq N, Holena DN, Braslow B, and Kohl B.  Major Abdominal Surgery:Postoperative Consideration..  In Lanken PN, Manaker S, Kohl BA, Hanson CW. Intensive Care Unit Manual: Expert Consult - Online and Print. Elsevier Science Health Science Division; 2013.
  8. Hoffman R and Holena DN.  Surgical Infections Disease.  In Porrett, P. M., Roses, R. E., Frederick, J. R., et al. (2015). The Surgical Review: An Integrated Basic and Clinical Science Study Guide: Wolters Kluwer Health. 2015
 
Awards, Honors and Membership in Honorary Societies
2015 Patrick M. Reilly Trauma Teaching Award, Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2013 Nominee, Best Oral Presentation European Congress of Trauma and Emergency Surgery
Basel, Switzerland
 
2012 Nominee, Best Oral Presentation European Congress of Trauma and Emergency Surgery
Basel, Switzerland
 
2011 1st Prize - Best Oral Presentation European Congress of Trauma and Emergency Surgery
Milan, Italy
 
2010 Penn Undergraduate Research Mentorship Grant recipient
 
2008 Fellow Nominee, 15th Pulmonary and Critical Care ACCP Fellows Conference
Philadelphia, Pennsylvania
 
2007 Hassan Nama Resident Teaching Award, Weill-Cornell Medical School Department of Surgery
 
2002 Merck Manual Award, State University of New York at Stony Brook School of Medicine
 
2002 Student Commencement Speaker
State University of New York at Stony Brook School of Medicine
 
2001  Alpha Omega Alpha (Junior Inductee)
State University of New York at Stony Brook School of Medicine

Dr. Daniel Holena

 
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