penn medicine
penn surgery
penn surgery home penn surgery clinical penn surgery education penn surgery research penn surgery administration

Daniel N. Holena, M.D.
Traumatology, Surgical Critical Care and Emergency Surgery

  • Profile Home
  • Appointments
  • Education
  • Memberships
  • Research
  • Publications

Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street, 5 Maloney
Philadelphia, PA 19104
Administrative Assistant: Desiree Gatto
Administrative Telephone: 215-662-7320
Administrative Fax: 215-614-0375

Clinical Office:
The Trauma Center at Penn
3400 Spruce Street, 2 Dulles
Philadelphia, PA 19104
Clinical Telephone: 215-662-7320
Clinical Fax:

Contact Information (internal use only)


Dr. Daniel Holena is board certified in General Surgery and Surgical Critical Care. He received his General Surgery training at Cornell, and completed is fellowship in Trauma Surgery and Surgical Critical Care at the University of Pennsylvania. Dr. Holena specializes in the treatment of traumatic injury, emergency general surgery conditions, and surgical critical care. His research interests include outcomes after emergency general surgery and triage biomarkers in acute trauma.

Faculty Appointments
2009 - present Assistant Professor of Surgery at HUP
Perelman School of Medicine
Philadelphia, Pennsylvania
Hospital and Administrative Appointments
2008 - present Senior Administrative Fellow
Division of Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
2008 - present Attending Trauma Physician
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
2008 - present Attending Intensivist, Penn e-lert eICU
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
2008 - present Attending Intensivist, Penn e-lert eICU
Pennsylvania Hospital
Philadelphia, Pennsylvania
2011 - present Physician Leader, Unit Based Clinical Leadership Silverstein 12
Hospital of the University of Pennsylvania
2011 - present Director of Surgical Rapid Response
Hospital of the University of Pennsylvania
2011 - present Director of Audiovisual Video Review, Division of Trauma
2011 - present Member, Clinical Emergencies Committee
2012 - present Member, ad hoc Code Improvement Committee
2013 - present 

Department of Surgery Representative, Telemedicine Committee

Editorial Positions
2011 - present Ad Hoc Reviewer, Injury
2011 - present Editor,  Journal of Trauma and Treatment
1991 - 1995 B.Sc. McGill University
Montreal, Canada (Biology)
1998 - 2002 M.D. State University of New York at Stony Brook
Stony Brook, New York
Postgraduate Training and Fellowship Appointments
2002 - 2003 Internship in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
2002 - 2007 Rotating Resident in Surgical Oncology
Memorial Sloan-Kettering Cancer Center
New York, New York
2003 - 2007 Resident in General Surgery
New York Presbyterian Hospital/
Weill-Cornell School of Medicine
New York, New York
2007 - 2009 Fellowship in Trauma and Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
Other Appointments
1998 - 2001 Student Representative, Class of 2002
State University of New York at Stony Brook School of Medicine
Stony Brook, New York
2008 - 2009 Instructor B in Surgery
University of Pennsylvania School of
Memberships in Professional and Scientific Societies:
National/International Societies:
  • Eastern Association for the Surgery of Trauma
  • Society of Critical Care Medicine
  • American College of Surgeons
  • American Medical Association
  • Association of Academic Surgeons
  • European Society of Trauma and Emergency Surgery
Local/Regional Societies
  • Pennsylvania Medical Society
Scientific Committee
  • EAST Thoracic and lumbar Spine Management Guideline Committee
Research Funding
7/2013 - 2015 NHLBI   K-12 Scholarship (K12 HL 109009)
Research Publications, Peer Reviewed
  1. Holena DN, Eachempati S, and Barie P. Biliary Tract Infections. In Rello J, Kollef MH, Diaz E, Rodriguez A, eds. Infectious Diseases in Critical Care. Second edition. Heidelberg. Springer-Verlag. 2007:595-605.
  2. Whalen W, Holena DN, Pryor JP. Cardiac Injury Severe blunt chest trauma leads to cardiac arrest. Journal of Emergency Medical Services 2008: 33;36-38.
  3. Weinberger LN, Holena DN, Powell EK, and Gracias V. Arc determination equals injury identification: trauma mantra applied to electrocution. Injury Extra 2008: 39; 389-391.
  4. Pieracci FM, Henderson P, Rodney JR, Holena DN, Genisca A, Ip I, Benkert S, Hydo L, Eachempati SR, Shou J, and Barie PS. MD, MBA. A Randomized, Double-blind, Placebo-controlled Trial of the Effects of Enteral Iron Supplementation on Anemia and Risk of Infection During Surgical Critical Illness. Surg Infect 2009: 10;9-19.
  5. Holena DN Tolstoy N, Mills AM, Fox A, and Levine J.  Cooler heads prevail: A case of intractable intracranial hypertension after liver transplantation treated with therapeutic hypothermia.  Am J Crit Care 21 (1): 75-76, 2011
  6. Holena DN, Hadler R, Wirtalla C, Carr BG, Morris JB, and Kelz RR.  Teaching status: The impact on emergency and elective surgical care in the U.S. Annals of Surgery 253 (5): 1017-1023, May 2011.
  7. Mills AM, Edwards, MJ, Shofer FS, Holena DN, Abbuhl SB. Older Age and Analgesia Administration in Emergency Department Patients with Abdominal or Back Pain. West J Emerg Med. 2011 Feb;12(1):43-50
  8. Holena DN, Mills AM, Carr BG, Wirtalla C, Sarani B, Kim P, and Kelz RR.   Transfer Status: A risk factor for Mortality in Patients with Necrotizing Fasciitis.   Surgery, 150 (3) : 363-370, Sept 2011
  9. Pascual JL, Holena DN, Vella M  Sicoutris C  Chandrakaladharan B, Fox A, Sarani B, Sims C, and Schwab, CW. Short Simulation Training Improves Objective Skills In Established Advanced Practitioners Managing Emergencies On The Ward And Surgical Intensive Care Unit.  J Trauma. 71 (2) , pp. 330-338
  10. Sakran JV, Holena DN, and Dickinson E.  Collaboration makes survival possible for thoracic injury patient.  Journal of Emergency Medical Services 33(8):28-31, March. 2012.
  11. Mollo A, E. Reinke CE,  Nelson C, Holena  DN, Kann B,  Williams N, Bleier J, and Kelz RR.  The Simulated Ward: Ideal for Training Clinical Clerks in an Era of Patient Safety. J Surg Research Available online 12 April 2012.
  12. Massey PR, Sakran JV, Sarani B, Sims CA, Pascual JP, Holena DN.  Hyperbaric Oxygen Therapy In Patients With Necrotizing Soft Tissue Infections.  J Surg Research. 172(2), 348.
  13. Tolstoy NS , Aized M , McMonagle MP, Holena DN, Pascual JL, Sonnad SS , Sims CA. Mineralocorticoid deficiency in hemorrhagic shock.  J Surg Research, In Press
  14. Shashaty M,  Gallop R, Meyer N, Lanken P, Holena DN, Localio R, Bellamy S, Kaplan S, and Christie J.  African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients.  Journal of Critical Care,  In Press
  15. Holena DN, Netzer G, Localio R,  Bellamy S, Gallop R, Meyer N, Shashaty M, Reilly PM, Lanken P, and Christie J.  The Association of Early Transfusion with Acute Lung Injury in Severely Injured Patients.  J Trauma In Press 
  16. Holena DN, Stoddard D. Martin ND, Winters B, Casey  J, Pascual  JL, Sims CA, Sarani, B.   Clinical Outcomes Following Invasive versus Non-Invasive Pre-Operative Stabilization of Closed Diaphyseal Femur Fractures.  Eur J Trauma, In Press
  17. Gallesio JMA, Holena DN, Huang J, Sims C, Levine J, Ying GS, Pascual JL. Erratum: Hypertonic saline is superior to mannitol in severe traumatic brain injury for hourly correction of intracranial pressure and cerebral perfusion pressure and brain oxygenation (Journal of the American College of Surgeons 215 (S54)). Journal of the American College of Surgeons 2013;216:176. January 2013.
  18. Georgoff P, Perales P, Laguna B, Holena D, Reilly P, Sims C. Colonic injuries and the damage control abdomen: Does management strategy matter? Journal of Surgical Research 2013;181:293-9. May 15th.
  19. Johnson NJ, Carr BG, Salhi R, Holena DN, Wolff C, Band RA. Characteristics and outcomes of injured patients presenting by private vehicle in a state trauma system. American Journal of Emergency Medicine 2013;31:275-81. February 2013.
  20. Mills AM, Holena DN, Kallan MJ, Carr BG, Reinke CE, Kelz RR. Effect of insurance status on patients admitted for acute diverticulitis. Colorectal Disease 2013;15:613-20. May 2013.
  21. Sensenig RL, Tolstoy NS, Holena DN. A spontaneously expelled bullet from the urethra: A case of undetected bladder injury after abdominal gunshot wound. Injury Extra 2013;44:58-9.
  22. Sims CA, Isserman JA, Holena D, Sundaram LM, Tolstoy N, Greer S, Sonnad S, Pascual J, Reilly P. Exception from informed consent for emergency research: Consulting the trauma community. Journal of Trauma and Acute Care Surgery 2013;74:157-66. January 2013.
  23. Tolstoy NS, Aized M, McMonagle MP, Holena DN, Pascual JL, Sonnad SS, Sims CA. Mineralocorticoid deficiency in hemorrhagic shock. Journal of Surgical Research 2013;180:232-7. April 2013.
Reviews in Peer Reviewed Research Publications (print or other media)
  1. Allen S, Holena DN, McCunn M, Kohl B, and Sarani B.  A Review of the Fundamental Principles and Evidence Base in the Use of Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Adult Patients J Intensive Care Med 26 :13-26, Jan 2011
Current Projects
  1. Holena DN and Sims C. Hormone concentration in banked blood products.
  2. Holena DN, McNicholas A, and Sarani B Initial lactate level does not predict injury severity or mortality in low-mechanism trauma.
Poster Presentations
  1. Holena DN, Horan AM, Sonnad S, and Gracias V. Service of admission does not affect outcome in patients with combined head and extremity injuries. Pennsylvania American College of Surgeons Committee on Trauma, Oct.. 2008. Harrisburg, PA
  2. Holena DN. Multiple great vessel injuries. Philadelphia Day of Trauma Dec 2008, Philadelphia PA
Lectures by Invitation
Feb 23, 2010 Trauma Clinical Outreach, Landsdale Fire Rescue
April 4, 2010 “Penetrating extremity vascular trauma”
Bayhealth Medical Center, Dover, DE
June 16, 2011 “Interhospital Transfer and the Quaternary Medical Center”
Mercy Suburban Medical Center, Norristown, PA        
Sept 13, 2011 “Prehospital Care of the Trauma Patient”
Department of Homeland Security, Philadelphia PA
Sept 20, 2011 “Prehospital Care of the Trauma Patient”
Department of Homeland Security, Philadelphia PA
Nov 5, 2011 Moderator, Philadelphia Annual Day of Trauma
Mar 14, 2012 Trauma Clinical Outreach, Plymouth Medic 308

Dr. Daniel Holena

footer Terms of Use Legal Disclaimer Site Map Contact Us Financial Assistance About Penn Medicine Privacy Statement
penn medicine