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Matthew H. Levine, M.D., Ph.D.
Transplant Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
1 Founders Building
Philadelphia, PA 19104
Adminitrative Assistant: Nancy Durnin
Administrative Telephone: 215-662-7367
Administrative Fax: 215-615-4900

Clinical Office:
Perelman Center for Advanced Medicine
West Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Clinical Telephone: 215-662-7367
Clinical Fax:
215-615-4900

Contact Information (internal use only)

matthew.h.levine@uphs.upenn.edu

 

Matthew Levine, MD, PhD, attended Brown University, followed by a combined MD/PhD at Yale. He completed his PhD in immunobiology in the laboratory of Charles Janeway Jr., with work focusing on the discovery of positive selection events in the peripheral development of B cells. He then went on to complete general surgery residency at the Massachusetts General Hospital and a fellowship in abdominal organ transplantation at the University of California, San Francisco. He joined the faculty at the University of Pennsylvania in 2009 in the Division of Transplantation. He is clinically active in liver and kidney transplantation in adults and children, pancreas transplantation, and laparoscopic kidney donation. He assumed the surgical directorship of the CHOP kidney transplant program in 2015.

Dr. Levine’s basic science research focuses on for key areas. 1. Defining the role and mechanism that histone deacetylases play in the tolerance of ischemia reperfusion injury. This work was the subject of an NIH/NIDDK K08 grant that yielded significant findings that class I HDAC inhibition or deletion can lead to substantial protection against ischemia reperfusion injury and subsequent chronic injury including fibrosis formation in a kidney warm and cold ischemia model. Further investigation is focused on specific class I HDAC members and further investigation in this area has been funded by and R01 from NIH/NIDDK. This workup has evolved into utilizing cellular molecular systems and is now focusing on the interaction between HDACs and nuclear corepressor complexes. The renal IRI work has now been extended into liver, lung, and limb ischemic injury models and the role of HDACs in these models is being investigated as well. The limb ischemia reperfusion injury work is an offshoot of combined efforts and vascularized composite tissue allotransplantation (VCA) and has been funded by a grant from the Department of Defense. 2. Defining the role that hormones in general and estrogen in particular play and the medication of ischemia reperfusion injury. This work is demonstrated that in animal models, 17 beta estradiol administration is protective against renal ischemia reperfusion injury. A human correlate was defined by analyzing the UNOS national transplant data and this work was published in JCI in 2016. Further investigation of this area is defining the role that estrogen receptor plays in the mitigation of renal ischemic injury and investigating the role that other hormones and estrogen receptor modulators have on ischemic injury and investing the role of these pathways and other organ ischemic systems. This work has directly led to a phase 1/early phase 2 randomized human interventional clinical trial investigating estrogen administration in female renal transplant patients to mitigate IRI. 3. In close collaboration with Dr. Wayne Hancock and Dr. Scott Levin, the Penn group has joined a 4 site DOD funded research consortium focused on VCA immunology and transplantation. Together, this group has successfully competed for 3 DOD grants and has extensive work investigating the role of various immunosuppressive and tolerance induction strategies in mouse models of VCA, investigation of the rule of Tregs in VCA, and investigation of tissue ischemia mitigation pathways in new mouse models of VCA. This work is informed by Dr. Levine’s participation in the clinical VCA programs at HUP and CHOP as part of the advisory team as well as assisting in immunosuppression management. 4. Dr. Levine’s laboratory in collaboration with that of Dr. Wayne Hancock and Dr. Ulf Beier have investigated clinical and translational aspects of Treg biology and topics directly relevant to transplantation.

Dr. Levine’s clinical research has focused on transplantation allocation policy and how it impacts transplant outcomes as well as center level decision making, pediatric renal transplantation with a focus on outcome optimization and organ allocation, and liver transplantation for hepatocellular carcinoma.  Because of his interest in hormonal impact on IRI, he has developed interest in sex determined outcomes disparities in transplantation as well.

Dr. Levine serves as chair of the CME committee for the American Society of Transplant Surgeons, serves on the basic science committee for the Society of University Surgeons, and is a member of the American Society of Transplantation (AST), the Association for Academic Surgery (AAS), the American College of Surgeons (ACS), the American Association for the Study of Liver Disease (AASLD), The Transplantation Society (TTS), and the International Liver Transplantation Society. He is a section editor and associated editor for the American Journal of Transplantation (AJT) and is on the editorial board of Liver Transplantation.

 
Faculty Appointments
2009 - present Assistant Professor of Surgery
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2007 - 2008 Instructor of Surgery
University of California at San Francisco
San Francisco, California
 
Hospital and Administrative Appointments
2015 - present   Surgical Director and Primary Surgeon, Kidney Transplantation
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
   
2009 - present Attending Surgeon
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2009 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2006 - 2006 Locum Tenens Attending in General Surgery
Kaiser Permanente Health System
San Francisco, California
 
Education/Training
1994 - 2001 PhD - Yale University School of Medicine
New Haven, Connecticut (Immunobiology)
 
1994 - 2001 MD - Yale University School of Medicine
New Haven, Connecticut
 
1990 - 1994 BS - Brown University
Providence, Rhode Island (Biochemistry)
 
Postgraduate Training and Fellowship Appointments
2007 - 2008 Fellowship, Abdominal Organ Transplantation
University of California Medical Center
San Francisco, California
 
2002 - 2006 Resident in Surgery, Massachusetts General Hospital
Boston, Massachusetts
 
2001 - 2002 Intern in Surgery, Massachusetts General Hospital
Boston, Massachusetts
 
Memberships/Societies
 
National/International Societies
2013 - present  The Society of University Surgeons (SUS)
Basic Science Committee 2015-present
 
2012 - present The Transplantation Society (TTS)
 
2010 - present  Association for Academic Surgery (AAS)
AAS Leadership Committee Member, 2012-2015
 
2010 - present  American Society of Transplantation (AST)
 
2010 - present  American Association for the Study of Liver Diseases (AASLD)
 
2009 - present International Liver Transplantation Society (ILTS)
 
2007 - present American Society of Transplant Surgeons (ASTS)
Candidate Member, 2007-2011
Full Member, 2011-present
CME Committee Member, 2010-present
Co-Chair 2013-2016
Chair, 2016-present
 
2005 - present  American College of Surgeons (ACS)
Candidate Member, 2005-2011
Fellow, 2011-present (FACS)

 

Local/Regional Societies

2011 - present  ACS, Greater Philadelphia Chapter, Member
 
Scientific Committees
2010 - present American Society of Transplant Surgeons (ASTS)
CME Committee
 
2010 - present Societyof University Surgeons (SUS)
Basic Science Committee, 2012-present
 
Editorial Positions
2015 - present Editorial Board, Liver Transplantation
 
2015 - present  Associate Editor, AJT
 
2015 - present Section Editor, Images in Transplantation (CME), AJT
 
Academic Committees at the University of Pennsylvania and Affiliated Hospitals
2009 - 2014  Physician Leader of Unit Based Clinical Leadership (UBCL) Team for Rhoads 4 Transplant Surgery Floor, Hospital of the University of Pennsylvania
 
Research
 
Dr. Levine's research interests are:
  • Histone deacetylase (HDAC) manipulation and ischemia reperfusion injury (IRI) mitigation
  • Hormonal impact on IRI and hormonal manipulation to minimize IRI in animal models and translational projects in human trials
  • Vascularized composite tissue allotransplantation (VCA) immunology and tissue injury
  • HDAC impact on regulatory T cell (Treg) function in transplantation
  • Hepatocellular carcinoma in liver transplantation
  • Organ allocation policy and impact on outcomes and center practices
  • Pediatric renal transplantation
 
Grants
8/2016 - 7/2017 Penn University Research Foundation Grant - Role: PI 
Peri-Operative Estrogen in Renal Transplantation (PERT) Trial
 
7/2016 - 6/2018 DOD RT150100: Peritransplant Treg-Based Immunomodulation to Improve VCA Outcomes - Role:Co-PI
 
7/2016 - 6/2018  DOD RT150071: Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation - Role: PI
 
7/2016 - 6/2021 NIDDK R01  DK106243-O1A1: HDAC2 Inhibition Mitigates Renal Ischemia Reperfusion Injury - Role: PI
 
7/2015 - 7/2016 Penn Institute for Immunology Pilot Grant - Role: PI
Mechanistic High Throughput Screening to Identify Means of HDAC2 Deletion-Associated Ischemia Tolerance
 
10/2013 - 9/2017  DoD  MR120023P3: Positioning Vascularized Composite Allotransplantation in the Spectrum of Transplantation – Department of Defense Consortium - Role: Co-PI
 
7/2011 - 4/2016 NIDDK KO8 1K08DK092282-01: Histone/Protein Deacetylase Inhibitors Minimize Renal Ischemia-Reperfusion Injury - Role: PI
 
7/2011 - 6/2012  P30-DK050306: Center for Molecular Studies in Digestive and Liver Diseases Pilot Project Grant - Role: PI  
 
7/2009 - 6/2010 McCabe Fund Intramural Pilot Grant - Role: PI 
The Role of Histone Deacetylase 6 in Regulatory T Cell Mediated Transplant Graft Tolerance
 
Publications
Research Publications, Peer Reviewed
  1. Janeway Jr CA, Annicelli C, Apicelli J, Barlow A, Baron J, Carrithers M, Chen C, Chervonsky A, Cohen B, Dittel B, Evans T, Granata J, Hardardottir F, He X, Kaye J, Levine M, Liu Y, Loysev G, Medzhitov R, Preston-Hurlburt P, Robinson E, Rudensky A, Sant’Angelo D, Shanabrough J, Viret C, Visintin I, Wong S.  The role of self-recognition in receptor repertoire development.  Immunologic Research 19(2/3):107-118, June 1999. PMID: 10493166
  2. Levine MH, Haberman AM, Sant’Angelo DB, Hannum LG, Shlomchik MJ, Janeway CA.  Peripheral selection of BCR repertoire in heavy chain transgenic mice.  Scandinavian Journal of Immunology 50:C11, July 1999.
  3. Levine MH, Haberman AM, Sant’Angelo DB, Hannum LG, Cancro MP, Janeway CA, Shlomchik MJ.  A B-cell receptor-specific selection step governs immature to mature B cell differentiation.   Proceedings of the National Academy of Science, USA 97:2743-2748, Mar. 14, 2000.
  4. He X, Janeway CA Jr, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K. Dual receptor T cells extend the immune repertoire for foreign antigens.  Nature Immunology 3:127-134, Feb. 2002.
  5. Porrett P, Kamoun M, Parson R, Bloom R, Goral S, Reese P, Grossman R, Baluarte J, Bleicher M, Doyle A, Markmann J, Levine M, Barker C, Olthoff K, Naji A, Shaked A, Abt P.  Kidney transplantation at the University of Pennsylvania 1998-2008.  Clinical Transplantation 143-152, 2009. PMID 20527069.
  6. Cassuto J, Reese P, Sonnad S, Bloom R, Levine M, Naji A, Abt P, Olthoff K, Shaked A. Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients. American Journal of Transplantation 10(11):2502-2511, Nov. 2010.  PMID 20977641.
  7. Levine MH, Parekh J, Feng S, Freise C.  Kidney transplant performed after liver transplant: A single center experience. Clinical Transplantation 25(6):915-920, Nov./Dec. 2011. [Epub Nov. 16, 2010]  PMID 21077957.
  8. Hsu J, Reese P, Naji A, Levine M, Abt P.  Increased early graft failure in right-sided living donor nephrectomy. Transplantation 91(1):108-114, Jan. 2011.  PMID 21441855.
  9. Levine MH.  Transplant tolerance and regulatory T cells: Let's get into specifics. Journal of Surgical Research 176(1):17-19,  July 2012. [Epub June 12, 2011]  PMID 21696771.
  10. Akimova T, Beier U, Wang L, Levine MH, Hancock W.  Helios expression is a marker of T cell activation and proliferation.  PLoS ONE 6(8):e24226, 2011. [Epub Aug. 30, 2011] PMID 21918685.
  11. Redfield R, Parsons R, Rodriguez E, Mustafa M, Cassuto J, Vivek K, Noorchashm H, Naji A, Levine M, Abt P.  Underutilization of A2 ABO incompatible kidney transplantation.  Clinical Transplantation 26(3):289-294, May 2012. [Epub Oct. 27, 2011] PMID 22032287.
  12. Cassuto J, Levine MH, Reese P, Bloom R, Goral S, Naji A, Abt P.  The influence of induction therapy for kidney transplantation after a non-renal transplant. Clinical Journal of American Society of Nephrology (CJASN) 7(1):158-166, Jan. 2012. [Epub Nov. 10, 2011] PMID 22076872.
  13. Porrett P, Levine MH.  Fever and suprapubic tenderness ten days after kidney transplantation.  American Journal of Transplantation 12(1):254-256, Jan. 2012.  PMID 22244125.
  14. Levine MH, Reese P, Wood A, Baluarte H, Huverserian A, Naji A, Abt P.  Inferior allograft outcomes in adolescent recipients of renal transplants from ideal deceased donors.  Annals of Surgery 255(3):556-564, Mar. 2012. PMID 22330037.
  15. Enestvedt CK, Levine MH.  Abdominal pain, fever and free air one year post simultaneous pancreas-kidney transplant. American Journal of Transplantation 12(6):1657-1659, June 2012. PMID 22642475
  16. Akimova T, Kamath BM, Goebel JW, Meyers KE, Rand EB, Hawkins A, Levine MH, Bucuvalas JC, Hancock WW.  Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients.  American Journal of Transplantation 12(12):3449-3461, Dec. 2012 PMID: 22994804.
  17. Harhay M, Lin E, Pai A, Harhay MO, Huverserian A, Mussell A, Abt P, Levine M, Bloom R, Shea JA, Troxel AB, Reese PP.  Early rehospitalization after kidney transplantation: Assessing preventability and prognosis.  American Journal of Transplantation 13(12):127-133, Dec. 2013 PMID: 24165498
  18. Ruebner R, Goldberg D, Abt PL, Bahirwani R, Levine M, Sawinski D, Shults J, Bloom RD, Reese PP.  Risk of end-stage renal disease among liver transplant recipients with pre-transplant chronic kidney disease.  American Journal of Transplantation 12(11):2958-2965, Nov. 2012. PMID 22759237
  19. Aufhauser DD Jr, Rose T, Levine M, Barnett R, Ochroch EA, Aukburg S, Greenblatt E, Olthoff K, Shaked A, Abt P.  Cardiac arrest associated with reperfusion of the liver during transplantation: incidence and proposal for a management algorithm.  Clinical Transplantation 27(2):185-192, Mar./Apr. 2013 PMID 23278482
  20. Parzych EM, Liu H, Yin X, Liu Q, Wu TL, Podsakoff G, High KA, Levine MH, Ertl HC.  Effects of immunosuppression on circulating AAV capsid-specific T cells in humans.  Human Gene Therapy 24(4):431-442, Apr. 2013 PMID: 23461589
  21. Wolf JH, Sulewski ME, Cassuto JR, Levine MH, Naji A, Olthoff KM, Shaked A, Abt PL.  Simultaneous thoracic and abdominal transplantation: can we justify two organs for one recipient?  American Journal of Transplantation 13(7):1806-1816, July 2013 (Epub May 29, 2013). PMID:23718142
  22. Hsu JW, Reese PP, Naji A, Levine MH, Abt PL.  Inferior early post-transplant outcomes for recipients of right versus left deceased and living donor kidneys.  American Journal of Transplantation 13(11):3048, Nov. 2013 PMID:24102734
  23. Yoo PS, Bonnel A, Kamoun M, Levine MH.  Clinical outcomes among renal transplant recipients with pre-transplant weakly reactive donor-specific antibodies.  Clinical Transplantation 28(1):127-133, Jan. 2014 PMID:24345281
  24. Reese PP, Bloom RD, Shults J, Thomasson A, Mussell A, Rosas SE, Johnasen KL, Abt P, Levine M, Caplan A, Feldman HI, Karlawish J.  Functional status and survival after kidney transplantation.  Transplantation 97(2):189-195. Jan 2014.  PMID: 24113514
  25. Bahirwani R, Forde KA, Mu Y, Lin F, Reese P, Goldberg D, Abt P, Reddy KR, Levine M. End-stage renal disease after liver transplantation in patients with pre-transplant chronic kidney disease. Clinical Transplantation 28(2):205-210. Feb 2014 PMID: 24382253
  26. Wolf JH, Bhatti TR, Fouraschen S, Chakravorty S, Wang L, Kurian S, Salomon D, Olthoff KM, Hancock WW, Levine MH.  Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice.  Liver Transplantation 20(3):376-385, Mar. 2014. PMID:24357103
  27. Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD; Lung Transplant Outcomes Group.  Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.  American Journal of Respiratory & Critical Care Medicine 189(5):567-575, Mar. 1, 2014. PMID:24467603
  28. Clayton EF, Malik S, Bonnel A, Mu Y, Olthoff K, Shaked A, Abt PL, Peterman H, Reddy KR, Ottmann S, Furth EE, Levine MH.  Liver transplantation and cirrhotomimetic hepatocellular carcinoma: Classification and outcomes.  Liver Transplantation 20(7):765-774, July 2014.  PMID:24668931
  29. Redfield RR, Gupta M, Rodriguez E, Wood A, Abt PL, Levine MH. Graft and patient survival outcomes of a third kidney transplant. Transplantation 99(2):416-423, Feb 2015. PMID: 25121473
  30. Sulewski ME, Wolf JH, Hasz R, West S, Goldberg D, Krok KL, Olthoff KM, Shaked A, Levine MH, Abt PL. Combined heart-liver transplantation: Implications for liver-alone wait list mortality. Transplantation 98(5):e45-47, Sept. 2014. PMID: 25171534.
  31. Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser Jr. DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW.  Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. American Journal of Transplantation 15(4):965-973, Apr. 2015. PMID: 25708614.
  32. Gupta M, Bahirwani R, Levine MH, Malik S, Goldberg D, Reddy KR, Shaked A. Outcomes in pediatric hepatitis C transplant recipients: Analysis of the UNOS database. Pediatric Transplantation 19(2):153-163, Mar. 2015. PMID: 25495572.
  33. Suryaprasad A, Basavaraju SV, Hocevar SN, Theodoropoulos N, Zuckerman RA, Hayden T, Forbi J, Pegues D, Levine M, Martin S, Kuehnert MJ, Blumberg EA. Transmission of hepatitis C Virus from organ donors with negative nucleic acid test screening prior to transplantation. American Journal of Transplantation 15(7):1827-1835, July 2015. PMID: 25943299
  34. Reese PP, Shults J, Bloom RD, Mussell A, Harhay MN, Abt P, Levine M, Johansen KL, Karlawish JT, Feldman HI.  Functional status, time to transplantation, and survival benefit of kidney transplantation among wait-listed candidates. American Journal of Kidney Disease 66(5):837-845, Nov. 2015 (Epub July 7, 2015). PMID: 26162652
  35. Gupta M, Wood A, Mitra N, Furth SL, Abt PL, Levine MH.  Repeat kidney transplantation after failed first transplants in childhood: Past performance informs future performance. Transplantation 99(8):1700-1708, Aug. 2015. PMID: 25803500
  36. Reese PP, Harhay MN, Abt PL, Levine MH, Halpern SD. New solutions to reduce discard of kidneys donated for transplantation.  Journal of the American Society of Nephrology 27(4):973-980. Apr 2016. PMID: 26369343
  37. Akimova T, Levine MH, Beier UH, Hancock WW.  Standardization, evaluation, and area-under-curve analysis of human and murine treg suppressive function.  Methods in Molecular Biology 1371:43-78, 2016. PMID: 26530794
  38. Abu-Gazala S, Abt PL, Levine MH.  Successful liver retrieval after acute aortic dissection involving the celiac artery origin. American Journal of Transplantation 16(1):365-367, Jan. 2016. PMID: 26781910
  39. Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH. Targeting Sirtuin-1 Prolongs Murine Renal Allograft Survival and Function. Kidney International 89(5):1016-1026, May 2016. PMID: 27083279
  40. Aufhauser DA, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH. Improved renal ischemia tolerance in females influences kidney transplantation outcomes. Journal of Clinical Investigation. 126(5):1968-1977, May 2, 2016. PMID: 27088798
  41. Keswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine MH, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM; Basic Science Committee of the Society of University Surgeons.  The future of basic science in academic surgery: Identifying barriers to success for surgeon-scientists.  Annals of Surgery (Epub Sept. 16, 2016) PMID: 27643928
  42. Rossidis A, Lim MA, Palmer M, Levine MH, Naji A, Bloom RD, Abt PL.  Kidney transplantation from a donor with sickle cell disease.  American Journal of Transplantation (Epub Sept. 24, 2016).  PMID: 27664974
  43. Goldberg D, Blumberg EA, McCauley M, Abt P, Levine, M.  Improving organ utilization to help overcome the tragedies of the opioid epidemic. American Journal of Transplantation 2016 (Epub Jul 20, 2016). PMID: 27438538.
  44. Parsons RF, Locke JE, Redfield RR, Roll GR, Levine MH.  Kidney Transplantation of Highly Sensitized Recipients Under the New Kidney Allocation System: A Reflection from Five Different Transplant Centers Across the United States.  Human Immunology. (Accepted October 2016).  PMID: 27773831
  45. Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Wang W, Levine MH, Wang Z, Quinn W, Kopinski PK, Wang L, Akimova T, Yujie L, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments. Cell Metabolism. Accepted December 2016.  PMID: pending (accepted for publication).

Reviews in Peer Reviewed Research Publications

  1. Levine MH, Abt P.  Treatment options and strategies for antibody mediated rejection after renal transplantation.  Seminars in Immunology 24(2):136-142, Apr. 2012. PMID 21940179.
Research Publications, Non-Peer Reviewed
  1. Levine MH.  Peripheral B cell selection on the basis of BCR: Identification and characteriza-tion.  PhD Thesis, Yale University School of Medicine, Department of Immunobiology, 2001.
  2. Wang G, Levine M.  Endovascular therapy for renal transplant salvage. Endovascular Today July 2010, 25-27.
Abstracts (Past 3 Years)
  1. Sulewski ME, Wolf JH, Hasz R, West S, Goldberg D, Levine MH, Abt PL.  Combined heart-liver transplantation increases mortality among liver wait list candidates. American Journal of Transplantation 13(Suppl 2):91-92, 2013.
  2. Clayton EF, Surrey LF, Grilliot MA, Levine MH, Furth EE.  Histopathologic features of primary hepatocellular carcinomas are poor predictors of extrahepatic metastasis. Laboratory Investigation 93(Suppl 1):399A-400A, 2013.
  3. Gupta M, Snider M, Wood A, Abt PL, Levine MH.  Second allograft outcomes in patients with renal transplants: Past performance informs future performance. Journal of the American College of Surgeons 217(3 Suppl 1):S144, 2013. 
  4. Gupta M, Porrett P, Goldberg D, Abt P, Levine M.  True MELD score is associated with HCC patient outcomes after liver transplant.  American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract 53, May 2013.  Note: Oral Presentation.
  5. Nair M, Lin E, Pai A, Harhay M, Huverserian A, Mussel A, Troxel A, Bloom R, Levine M, Abt P, Shea J, Reese P.  Early rehospitalization after kidney transplantation: Predictors and prognosis.  American Transplant Congress, Seattle, WA, May 2013.  American Journal of Transplantation 13(S5): Abstract 94, May 2013.  Note: Oral Presentation.
  6. Nair M, Lin E, Pai A, Harhay M, Huverserian A, Mussel A, Troxel A, Levine M, Shea J, Abt P, Bloom R, Reese P.  Assessment of preventable and non-preventable early rehospitalization following kidney transplantation.  American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract 95, May 2013.  Note: Oral Presentation.
  7. Stevens D, Trofe-Clark J, Blumberg E, Wilck M, Goral S, Bleicher M, Sawinski D, Abt P, Levine M, Porrett P, Bloom R.  Increased risk of breakthrough infection among cytomegalovirus donor positive/recipient negative kidney transplant recipients receiving lower dose valgancyclovir prophylaxis.  American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract B970, May 2013.
  8. Redfield R, Wood A, Abt P, Levine M.  The survival benefit of a third kidney transplant. American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract C377, May 2013.Note: Oral Presentation
  9. Levine MH, Wang Z, Wang Y, Redfield RR, Abt PL, Wang L, Hancock WW.  Gender difference in renal ischemia tolerance is extrinsic to the kidney. American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract C1198, May 2013.
  10. Gupta M, Wood A, Mitra N, Furth S, Abt P, Levine M.  First kidney graft survival is associated with second kidney transplant outcomes in pediatric patients with highly recurrent disease. American Transplant Congress, Seattle, WA, May 2013. American Journal of Transplantation 13(S5): Abstract C1420, May 2013.
  11. Gupta M, Wood A, Mitra N, Furth S, Abt P, Levine M.  Good second kidney transplant outcomes in pediatric patients with early first kidney graft loss. American Transplant Congress, Seattle, WA, May 2013.  American Journal of Transplantation 13(S5): Abstract C1427, May 2013.
  12. Akimova T, Kamath B, Goebel J, Meyers KEC, Rand EB, Levine MH, Bucuvalas JC, Hancock WW.  Problems and pitfalls in calculation of “true” Treg numbers using assays of Foxp3 TSDR demethylation in PBMC of transplant recipients. American Transplant Congress, Seattle, WA, May 2013.  American Journal of Transplantation 13(S5): Abstract D1722, May 2013.
  13. Gupta M, Snider M, Wood A, Abt P, Levine M.  Second allograft outcomes in patients with renal transplants: Past performance informs future performance. American College of Surgeons Surgical Forum, Washington, DC, Sept. 2013. Journal of the American College of Surgeons 217(3):S1-S162, Sept. 2013.  Note: Oral Presentation.
  14. Levine MH, Wang Z, McNeal S, Batti T, Hancock WW.  Gender differences in murine ischemia reperfusion tolerance is extrinsic to the kidney itself: Lessons from transplantation. ASN Kidney Week 2013, Atlanta, GA, Nov 2013.  Journal of the American Society of Nephrology (JASN) Abstract Supplement 2013, Abstract FR-PO065 24:380A.
  15. Levine MH.  Gender differences in murine ischemia reperfusion tolerance is extrinsic to the kidney itself: Lessons from transplantation.  Academic Surgical Congress, San Diego, CA, Feb. 2014. Note: SUS New Member Poster Presentation.
  16. Gupta M, Wood A, Abt PL, Levine MH.  The impact of the Share 35 policy on first allograft outcomes among kidney transplant recipients. American Society of Transplant Surgeons, Winter Symposium, Miami FL. Jan 2014.  American Journal of Transplantation Abstract P-22, 14(S2):75, Jan. 2014.
  17. Levine MH, Wang Z, McNeal S, Cheraghlou S, Han R, Wang L, Bhatti T, Hancock WW.  HDAC2 deletion leads to increased tolerance of renal ischemia reperfusion injury. World Transplant Congress, San Francisco, CA, July 2014.  Transplantation 98(Suppl 1):1-905, July 15, 2014.
  18. Levine MH, Wang Z, McNeal S, Cheraghlou S, Han R, Wang L, Bhatti T, Hancock WW.  Gender differences in renal ischemia tolerance are extrinsic to the kidney and estrogen administration is protective.  World Transplant Congress, San Francisco, CA, July 2014. Note: Invited Oral Presentation. Transplantation 98(Suppl 1):1-905, July 15, 2014.
  19. Gupta M, Wood A, Abt P, Levine MH.  Better HLA matching is associated with first and second allograft outcomes among pediatric renal transplant recipients. World Transplant Congress, San Francisco, CA, July 2014. Note: Invited Oral Presentation.  Transplantation 98(Suppl 1):1-905, July 15, 2014.
  20. Reese P, Harhay M, Bloom R, Shults J, Mussell A, Johansen K, Abt P, Levine M, Karlawish J, Feldman H.  Functional status, change in function, and outcomes for patients awaiting a kidney transplant. World Transplant Congress, San Francisco, CA, July 2014. Note: Invited Oral Presentation. Transplantation 98(Suppl 1):1-905, July 15, 2014.
  21. Aufhauser Jr DD, Wang Z, Cheraghlou S, Wang Y, Bhatti T, Hancock WW, Levine MH. HDAC2 gene deletion protects from renal ischemia-reperfusion injury and is intrinsic to renal tissue. American Society of Transplant Surgeons, 14th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan. 2015. American Journal of Transplantation Abstract O-4, 15(S1):49, Jan. 2015. Selected Oral Presentation.
  22. Cheraghlou S, Wang Z, Aufhauser Jr. DD, Wang Y, Bhatti T, Hancock WW, Levine MH.  Mediation of post-ischemia renal damage by intraperitoneal administration of estrogen. American Society of Transplant Surgeons, 14th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2015. American Journal of Transplantation Abstract P-37, 15(S1):69, Jan. 2015.  Poster of Distinction.
  23. Kaur N, Goral S, Kearns J, Abt PL, Naji A, Levine MH, Kamoun M.  Kidney transplant outcomes in patients with CPRA values p99% after the implementation of Abstracts (Past 3 Years, cont.):
    Abstracts (Past 3 Years, cont.):
    the new OPTN/UNOS kidney allocation system (KAS): A single center study.  Human Immunology 76(Suppl 1):114, 2015.
  24. Folkert IW, Goldberg DS, Levine MH, Olthoff KM, Shaked A, Abt PL.  Graft survival following domino liver transplantation: The U.S. experience. Hepatology 62(Suppl 1): 639A, 2015.
  25. Gupta G, Abt P, Levine MH. Better human leukocyte antigen matching is associated with graft outcomes among pediatric kidney transplant recipients. ASN Kidney Week 2014, Philadelphia, PA, Nov 2014. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract FR-OR096 25:69A.
  26. Levine MH, Wang Z, Cheraghlou S, Wang L, Bhatti T, Hancock WW.  Gender differences in renal ischemia tolerance are mutable and based on ischemia environment. ASN Kidney Week 2014, Philadelphia, PA, Nov 2014. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract TH-PO167 25:146A.
  27. Levine MH, Wang Z, Cheraghlou S, Wang L, Bhatti T, Hancock WW. HDAC2 deletion leads to substantial increase in tolerance of ischemia reperfusion injury. ASN Kidney Week 2014, Philadelphia, PA, Nov 2014. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract TH-PO205 25:155A.
  28. Wang L, Samanta A, Huang J, Bhatti T, Wang Z, Han R, Levin L, Levine M, Hancock W.  Peritransplant costimulation blockade and rapamycin therapy induces permanent limb allograft survival.  American Transplant Congress, Philadelphia, PA, May 2015. American Journal of Transplantation 15(S3): Abstract 324, May 2015.  Note: Invited Oral Presentation.
  29. Aufhauser D, Wang Z, Cheraghlou S, Bhatti T, Hancock W, Levine M.  Profound effect of HDAC2 deletion on renal ischemia-reperfusion injury is intrinsic to the kidney and includes protection against cold ischemia.  American Transplant Congress, Philadelphia, PA, May 2015. American Journal of Transplantation 15(S3): Abstract 659, May 2015.
  30. Wang L, Samanta A, Huang J, Bhatti T, Wang Z, Han R, Levin L, Levine M, Hancock W.  Clinically relevant anti-TCR mAb induction plus brief rapamycin therapy can achieve long-term vascularized composite allograft (VCA) survival. American Transplant Congress, Philadelphia, PA, May 2015. American Journal of Transplantation 15(S3): Abstract 709, May 2015.  Note: Invited Oral Presentation.
  31. George J, Eddinger D, Goldberg D, Levine M, Abt P.  Verification of OPTN hepatocellular carcinoma recurrence data. American Transplant Congress, Philadelphia, PA, May 2015.  American Journal of Transplantation 15(S3): Abstract 975, May 2015.
  32. Aufhauser D, Eddinger K, Furth E, Abt P, Levine M.  Unrecognized synchronous hepatocellular carcinoma lesions in explanted liver transplant specimens. American Transplant Congress, Philadelphia, PA, May 2015.  American Journal of Transplantation 15(S3): Abstract 1585, May 2015.
  33. Levine M, Thomasson A, Aufhauser D, Redfield R, At P, Reese P.  Gender differences in kidney transplant delayed graft function are independent of donor-recipient size mismatch. American Transplant Congress, Philadelphia, PA, May 2015. American Journal of Transplantation 15(S3): Abstract 1607, May 2015.  Note: Invited Oral Presentation.
  34. George J, Eddinger D, Goldberg D, Levine M, Abt P.  Verification of OPTN hepatocellular carcinoma recurrence data. American Transplant Congress, Philadelphia, PA, May 2015.  American Journal of Transplantation 15(S3): Abstract 975, May 2015.
  35. Glaser JD, Levine MH, Doll SL, Durinka JB, Davis JT, Fairman RM, Jackson BM, Foley PJ, Damrauer SM, Wang GJ. Duplex ultrasound criteria for the postoperative liver transplant patient. Journal of Vascular Surgery 61(6):70S, June 2015.
  36. Beier UH, Wang Z, Bhatti T, Hancock WW, Levine MH.  Pharmacologic targeting of Sirtuin-1 (Sirt-1) enhances Treg function, markedly prolongs renal allograft survival and protects against renal allograft dysfunction. ASN Kidney Week, San Diego, CA, Nov. 2015. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract TH-OR071, 26:18A.
  37. Beier UH, Wang Z, Hancock WW, Levine MH.  Use of D-lactate for therapeutic immunosuppression. ASN Kidney Week, San Diego, CA, Nov. 2015. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract TH-PO272, 26:151A.
  38. Aufhauser D, Wang Z, Ge G, Bhatti T, Hancock WW, Levine MH.  Reciprocal effects of HDAC1 and HDAC2 deletion on renal ischemia-reperfusion injury are intrinsic to the kidney. ASN Kidney Week, San Diego, CA, Nov. 2015. Journal of the American Society of Nephrology (JASN) Abstract Supplement 2015, Abstract SA-PO249 26:684A.
  39. Murken DR, Aufhauser DD, Peng AW, Goldberg DS, Levine MH. Same policy, different impact: Center and regional effects of SHARE35 liver allocation. American Society of Transplant Surgeons, 15th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan. 2016. American Journal of Transplantation Abstract P-15, 16(S1):34, Jan. 2016.
  40. Aufhauser DD, Murken DR, Wang Z, Ge G, Bhatti TR, Hancock WW, Levine MH.  HDAC2 deletion mitigates renal injury after prolonged cold ischemia prior to transplant. American Society of Transplant Surgeons, 15th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan. 2016.  American Journal of Transplantation Abstract P-47, 16(S1):46, Jan. 2016.  Resident Poster Award ASTS.
  41. Aufhauser DD Jr, Murken D, Wang Z, Ge G, Bhatti TR, Hancock WW, Levine MH. HDAC11 deletion increases tolerance of warm renal ischemia-reperfusion injury. American Society of Transplant Surgeons, 15th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2016.  American Journal of Transplantation Abstract P-48, 16(S1):46, Jan. 2016.
  42. Morrison A, Sawinski D, Lim M, Levine M, Kamoun M, Porrett P.  Type of sensitization does not impact kidney graft outcome in weakly sensitized patients. American Transplant Congress, Boston, MA June 2016.  American Journal of Transplantation 16(S3): Abstract 307, June 2016.
  43. Amaral S, Levine MH, Chang B, Lopez S, McAndrew C, Kessler S, Shaked A, Levin LS.  First bilateral hand transplant in a child: Short-term medical outcomes and challenges. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 596, June 2016.Note: Invited Oral Presentation.
  44. Kaur N, Goral S, Kearns J, Abt P, Naji A, Porrett P, Levine M, Kamoun M.  Kidney transplant outcomes in patients with CPRA values >98% after implementation of the new OPTN/UNOS Kidney Allocation System (KAS): A single center study update. American Transplant Congress, Boston, MA, June 2016.  American Journal of Transplantation 16(S3): Abstract 674, June 2016.
  45. Murken DR, Aufhauser Jr DD, Wang Z, Ge G, Hancock WW, Levine MH.  Histone deacetylase-2 gene deletion in mice mitigates liver ischemia/reperfusion injury. American Transplant Congress, Boston, MA June 2016. American Journal of Transplantation 16(S3): Abstract 810, June 2016.
  46. Aufhauser DD, Murken D, Wang Z, Samanta A, Ge G, Bhatti TR, Hancock WW, Levine MH.  Reciprocal effects of HDAC1 and HDAC2 deletion on renal cold ischemia survival and nuclear co-repressor complex expression. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 949, June 2016.
  47. Cendales L, Levine MH, Bartlett S, Cheeseman J, Drachenberg C. Hancock WW, Joshi M, Kirk AD, Leopardi F, Levin S, Mehmet C, Selim A, Song M, Twaddell W, Wang L, Wang Z, Barth R.  Skin as a harbinger of rejection of underlying structures in VCA: Concordance or discordance? American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 994, June 2016.
  48. Gupta M, Levine MH, Abt P.  Hematopoietic cell transplant and solid organ transplantation: A first report of the U.S. experience. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 1495, June 2016.  Note: Invited Oral Presentation.
  49. Murken DR, Peng, AW, Aufhauser DA, Abt PL, Goldberg DL, Levine MH.  Same policy, different impact: Center and regional effects of Share 35 liver allocation. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 1631, June 2016.
  50. Aufhauser DA, Sadot E, Murken DR, Eddinger KC, Goldberg DS, Furth EE, Abt PL, DeMatteo RP, Levine MH.  Occult multifocal hepatocellular carcinoma in surgical patients. American Transplant Congress, Boston, MA June 2016. American Journal of Transplantation 16(S3): Abstract 1848, June 2016.
  51. Potluri V, Nazarian S, Levine M, Reese P.  Imminent death donation: Potential effects on organ donation numbers and clinical outcomes. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 1909, June 2016.
  52. Wang L, Han R, Wang Z, Bhatti TR, Levin LS, Levine MH, Hancock WW.  Rapamycin (RPM) synergizes with CD154 mAb plus DST to promote long-term composite vascularized allograft (VCA) survival, but prevents induction of donor-specific tolerance. American Transplant Congress, Boston, MA, June 2016.  American Journal of Transplantation 16(S3): Abstract 2147, June 2016.
  53. Beier UH, Jiao J, Xiao H, Angelin A, Wallace DC, Levine MH, Hancock WW.  Learning from cancer: Using d-lactate for therapeutic immunosuppression. American Transplant Congress, Boston, MA, June 2016. American Journal of Transplantation 16(S3): Abstract 2244, June 2016.
  54. Murken D, Aufhauser DD Jr, Wang Z, Ge G, Bhatti TR, Hancock WW, Levine MH. Histone deacetylase-2 gene deletion in mice extends tolerance of renal ischemia/reperfusion injury. Academic Surgical Congress, Jacksonville, FL, Feb. 2016. Abstract 04-16, ASC 2016 Searchable Abstracts on-line (http://www.asc-abstracts.org/).  Selected Oral Presentation.
  55. Aufhauser DD, Murken D, Wang Z, Ge G, Samanta A, Bhatti TR, Hancock WW, Levine MH.  Reciprocal effects of HDAC1 and HDAC2 deletion on renal cold ischemia survival and nuclear co-repressor complex expression.  Metropolitan Philadelphia Chapter of American College of Surgeons Annual Joint Meeting Dinner, May, 2016.
  56. Aufhauser DD Jr, Murken D, Wang Z, Ge G, Bhatti TR, Hancock WW, Levine MH.  Gender differences in murine renal ischemia-reperfusion injury are mutable with hormonal manipulation. Academic Surgical Congress, Jacksonville, FL, Feb. 2016. Abstract 31-03, ASC 2016 Searchable Abstracts on-line (http://www.asc-abstracts.org/).  Selected Oral Presentation.
  57. Levin LS, Amaral S, Kovach S, Levine MH, Lee, B.  The world's first pediatric bilateral hand transplant. American Transplant Congress, Boston, MA June 2016.  Note: Video Oral Presentation.
  58. Peng A, Elchediak D, Gupta M, Amaral S, Nazarian SM, Levine MH. New KAS May Inappropriately Limit Access of Pediatric Donor Kidneys to Pediatric Recipients Based on KDPI.  ASN Kidney Week, Chicago, IL.  Nov 2016.
  59. Aufhauser DD, Murken D, Wang Z, Ge G, Bhatti T, Hancock WW, Levine MH.  Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury. ASN Kidney Week, Chicago, IL.  Nov 2016.
  60. Goldberg D, Karp S, Gilroy R, Levine MH, Abt PL.  Changes in Center Liver Acceptance Patterns Following Implementation of Share 35.  AASLD Liver Meeting, Boston, MA, Nov 2016.  Note: Invited Oral Presentation
  61. Aufhauser DD, Murken D, Wang Z, Samanta A, Ge G, Bhatti T, Hancock WW, Levine MH. Inhibition of CoREST Reverses HDAC2-Mediated Protection from Renal Ischemia.  16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017.  Note: Invited Oral Presentation.
  62. Gupta M, Morrison A, Sawinski D, Lim MA, Lloyd K, Kamoun M, Levine MH, Porrett P.  The Impact of DSA and HLA Matching on Kidney Graft Outcomes in Weakly Sensitized Patients. 16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017. 
  63. Simpson D, Amaral S, Levine MH.  Understanding Driving Forces in Disparate Living Kidney Donor Rates Among Blacks.  16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017. 
  64. Peng A, Levine MH. Long-Term Dialysis Exposure and the New KAS - Expected Outcomes.  16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017. 
  65. Murken D, Aufhauser D, Wang Z, Ge G, Hancock WW, Levine MH.  Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice. 16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017. 
  66. Gupta M, Peng A, Elchediak D, Amaral S, Nazarian SM, Levine MH.  Limitations in Access to Pediatric Donor Kidney for Pediatric Recipients Under the New Kidney Allocation System. 16th Annual State of the Art Winter Symposium, Miami Beach, FL, Jan 2017. 
  67. Aufhauser DD, Murken D, Wang Z, Ge G, Bhatti T, Hancock WW, Levine MH. Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.  12th Annual Academic Surgical Congress, Las Vegas, NV, Feb, 2017.  Note: Invited Oral Presentation  

Editorials, Chapters & Participation in Committee Reports

  1. Levine M, Feng S.  Clinical allograft rejection syndromes: Diagnosis and management: Liver.  Chap. 70 in Kirk A, Knechtle S, Larsen C, Madsen J, Pearson T (eds.):  Textbook of Organ Transplantation.  Hoboken, NJ:  John Wiley & Sons, 2014, 789-801.
  2. Levine MH.  Liver transplant: Standard arterial reconstruction.  Chap. in Mulholland M , Albo D, Engelsbe M, Hawn M, Hughes S, Sabel M, Dalman R (eds.): Operative Techniques in Surgery.  2015. 179-184.
  3. Aufhauser DA, Levine M.  Immunology and transplantation. Chap. 5 in Porrett PM, Atluri P, Karakousis GC, Roses RE, Drebin JA (eds.): The Surgical Review, 4th Edition. Philadelphia: Wolters Kluwer, 2016, 54-68.
 
Awards, Honors and Membership in Honorary Societies
2011 “Top 10” Oral Abstract, 11th Annual ASTS Winter Symposium
Hollywood, Florida
 
2009 McCabe Fund Pilot Research Award
University of Pennsylvania
 
2007 Fellows Excellence in Research Award, Fellows Educational Travel Grant
Transplant Summit 2007: Defining the Future, Chicago, Illinois
 
2001 The MD/PhD Award, Yale University School of Medicine
 
1994 Medical Scientist Training Program Fellowship (NIH) for MD/PhD training
Yale University School of Medicine
 
1994 Elected to Phi Beta Kappa, Biochemistry Honors
Leallyn B. Clapp Prize for best senior honors thesis in biochemistry, Brown University
 
1994  Ratcliffe Hicks Prize in Theater, Speech, and Dance for Excellence in Debate
Brown University
 
1993  Elected to Sigma Xi, Howard Hughes Grant Fellowship for Summer Research
Brown University
 
1993   Named Faculty Scholar by nomination and election of faculty
Susan Rosenberger Prize for Outstanding Junior Concentrator in Biochemistry
Brown University
 
1992   Undergraduate Teaching and Research Assistantship Grant for summer research
Brown University

Dr. Matthew Levine

 
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