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José L. Pascual, M.D., Ph.D., FRCS(C), FRCP(C)
Traumatology, Surgical Critical Care and Emergency Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street, 5 Maloney
Philadelphia, PA 19104
Administrative Assistant: Myra Rodriguez
Administrative Telephone: 215-662-7323
Administrative Fax: 215-349-5917

Clinical Office:
The Trauma Center at Penn
3400 Spruce Street, 2 Dulles
Philadelphia, PA 19104
Clinical Telephone: 215-662-7320
Clinical Fax: 215-614-0375

Contact Information (internal use only)

jose.pascual@uphs.upenn.edu

 

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada.  He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects.  In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives.  His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock. 

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses.  Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

 
Faculty Appointments
2005 - 2007 Instructor in Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2007 - present Assistant Professor of Surgery at HUP
Perelman School of Medicine
Philadelphia, Pennsylvania
 
2011 - present Clinical Associate
University of Pennsylvania School of Nursing
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
2006 - present Attending Surgeon
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2006 - present Attending Surgeon, St Luke’s Hospital
Bethlehem, Pennsylvania
 
2007 - present Attending Surgeon
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
 
2007 - present Attending Surgical Intensivist
Pennsylvania Hospital
Philadelphia, Pennsylvania
 
2007 - present

Attending Intensivist, Penn e-lert eICU
Philadelphia, Pennsylvania

 
2012 - present Patient Safety Officer, Department of Surgery
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Education/Training
1989 - 1990 McGill University (Physiology)
Montreal, Quebec
 
1990 - 1992 University of Ottawa (Biochemistry; no degree)
Ottawa, Ontario
 
1992 - 1996 M.D. University of Ottawa
Ottawa, Ontario
 
1999 - 2005 Ph.D. McGill University
Montreal, Quebec
 
1996 - 2005 FRCS(C) McGill University
Montreal, Quebec
 
Postgraduate Training and Fellowship Appointments
1996 - 2005 Fellowship with the Royal College of Surgeons of Canada
(equivalent to U.S. internship and residency)
McGill University, Montreal, Quebec
 
2005 - 2007 Fellowship, Trauma & Surgical Critical Care
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
Memberships/Societies
 
National/International Societies
  • American College of Surgeons (Candidate Member, 1999 - present)
  • Canadian Association of General Surgeons (Member, 1997 - present)
  • Royal College of Physicians & Surgeons of Canada (Fellow, 2005 - present)
  • Society of Critical Care Medicine (Member, 2000 - present)
  • Trauma Association of Canada (Member, 1999 - present)
  • Pan-American Trauma Society (Member 2007 - present)
  • International Society of Surgery (Member 2007 - present)
  • International Association for Trauma Surgery & Intensive Care (Member 2007 - present)
  • Eastern Association for the Surgery of Trauma (Member 2008 - present)
  • Association for Academic Surgery (Member 2011-present)
  • National Neurotrauma Society (Member 2012-present)
Local/Regional Societies
  • Pennsylvania Chapter of American College of Surgeons (member 2008 - present)
Scientific Committees
  • Eastern Association of Trauma (EAST) – Membership Committee (01/30/11 - 01/30/13)
  • Society of Critical Care Medicine (SCCM) – Education Committee (01/30/11 - 01/30/14)
  • Society of Critical Care Medicine (SCCM) – Research Committee (01/30/11 - 01/30/14)
  • Eastern Association of Trauma (EAST) – Research-Scholarship Comm. (01/30/13 - 01/30/15)
  • Society of Critical Care Medicine – Research section secretary/treasurer (07/01/13 - 07/01/15)
  • Society of Critical Care Medicine – Surgery Section Member (07/01/12 - present)
  • American Board of Surgery (ABS) Examination Comm. – Trauma representative (06/01/13 - present)
 
Research
Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.
 
Publications
 
Research Publications, Peer Reviewed
  1. Pascual JL, Ferri LE, Chaudhury P, Seely AJ, Campisi G, Giannias B, Evans DC, Christou NV. Hemorrhagic shock resuscitation with a low molecular weight starch reduces neutrophil-endothelial interactions and vessel leakage in vivo. Surgical Infections 2(4):275-288, 2001.
  2. Seely AJ, Naud JF, Campisi G, Giannias B, Liu S, DiCarlo A, Ferri LE, Pascual JL, Tchervenkov J, Christou NV. Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo. Annals of Surgery 235(4):550-559, Apr. 2002.
  3. Pascual JL, Ferri LE, Seely AJE, Campisi G, Chaudhury P, Giannias B, Evans DC, Razek T, Michel RP, Christou NV. Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage. Annals of Surgery 236(5):634-642, May 2002.
  4. Ferri LE, Pascual J, Seely AJ, Chaudhury P, Christou NV. Soluble L-selectin attenuates tumor necrosis factor-alpha-mediated leukocyte adherence and vascular permeability: a protective role for elevated soluble L-selectin in sepsis. Critical Care Medicine 30(8):1842-1847, Aug. 2002.
  5. Pascual JL, Khwaja KA, Ferri LE, Giannias B, Evans DC, Razek T, Michel RP, Christou NV. Hypertonic saline resuscitation attenuates neutrophil lung sequestration and transmigration by diminishing leukocyte-endothelial interactions in a two-hit model of hemorrhagic shock and infection. Journal of Trauma-Injury Infection & Critical Care 54(1):121-132, Jan. 2003.
  6. Ferri LE, Pascual J, Seely AJ, Giannias B, Christou NV. Intra-abdominal sepsis attenuates local inflammation-mediated increases in microvascular permeability at remote sites in mice in vivo. Surgery 135(2):187-195, Feb. 2004.
  7. Pascual JL, Maloney-Wilensky E, Reilly PM, Sicoutris C, Keutmann MK, Stein SC, LeRoux PD, Gracias VH. The effect of an institutional pathway on TBI resuscitation with 7.5% hypertonic saline. American Surgeon Vol 74(3):253-9, March 2008.
  8. Oddo M, Levine JM, Frangos S, Carrera E, Maloney-Wilenski E, Pascual JL, Kofke A, Mayer SA, Leroux PD. Effect of Osmotherapy with Mannitol and Hypertonic Saline on Cerebral Tissue Oxygenation in Patients with Severe Traumatic Brain Injury and Refractory Intracranial Hypertension. J Neurol Neurosurg Psychiatry. 2009 Mar 16 [Epub]
  9. Phelan, H., Velmahos, G., … Pascual, J.,…An Evaluation of Multi-Detector Computed Tomography in Detecting Pancreatic Injury: Results of a Multicenter AAST Study The Journal of Trauma 66(3):121-129, Mar 2009.
  10. Babak Sarani, Brandy Temple-Lykens, Patrick Kim, Seema Sonnad, Meredith Bergey, Jose L. Pascual, Carrie Sims, Patrick Reilly. Factors Associated with Mortality and Brain Injury Following Fall from the Standing Position. Journal of Trauma 67(5):954-958 November 2009.
  11. Ding W, Wu X, Pascual JL, Zhao K, Ji W, Li N, Li J. Temporary intravascular shunting improves survival in a hypothermic traumatic shock swine model with superior mesenteric artery injuries. Surgery. 2010 Jan;147(1):79-88.
  12. Pascual JL., Georgoff P, Maloney-Wilensky E, Sims C, Sarani B, Stiefel M, LeRoux PD, Schwab C. Reduced Brain Tissue Oxygen in Traumatic Brain injury: Are most commonly used interventions successful? J Trauma 2011 Mar;70(3):535-46.
  13. Sarani B, Palilonis E, Sonnad S, Bergey M, Sims C, Pascual J, Schweickert W. Clinical Emergencies and outcomes in Patients Admitted to a Surgical vs. Medical Service. Resuscitation 2011 Apr, 82(4):415-8.
  14. Sarani B, Powell E, Taddeo J, Carr B, Patel A, Seamon M, Wobb J, Sims C, Pascual J, Schwab CW. A Contemporary Comparison of Surgical and Interventional Arteriography Management of Blunt Renal Injury J Vasc Interv Radiol 2011 May;22(5):723-8.
  15. Sims C, Sabra D, Bergey MR, Grill E, Sarani B, Pascual J, Kim P, Datner E. Detecting intimate partner violence: more than trauma team education is needed. J Am Coll Surg. 2011 May;2012(5):867-72.
  16. Pascual JL, Holena DN, Vella MA, Palmieri J, Sicoutris C, Selvan B, Fox AD, Sarani B, Sims C, Williams NN, Schwab CW. Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit. J Trauma. 2011 Aug;71(2):330-7.
  17. Gong W, Marks JA, Sanati P, Sims C, Sarani B, Smith DH, Pascual JL. Hypertonic saline resuscitation of hemorrhagic shock does not decrease in vivo neutrophil interactions with endothelium in the blood-brain microcirculation. J Trauma. 2011 Aug;71(2):275-81.
  18. Morris DS, Rohrbach J, Rogers M, Thanka Sundaram LM, Sonnad S, Pascual J, Sarani B, Reilly P, Sims C. The surgical revolving door: risk factors for hospital readmission. J Surg Res. 2011 Oct;170(2):297-301.
  19. Kofke WA, Horak J, Stiefel M, Pascual J. Viable oxygenation with cannula-over-needle cricothyrotomy for asphyxial airway occlusion. Br J Anaesth. 2011 Oct;107(4):642-3.
  20. Menger R, Foreman J, Sarani B, Pascual J, Reilly P, Bergey M. Risk Factors Associated With Chest Tube Complications Following Thoracic Injury. Injury 2012 Jan;43(1):46-50.
  21. Sakran J, Finneman B, Maxwell C, Sonnad S, Sarani B, Pascual J, Kim P, Schwab W, Sims C. Trauma Leadership: Does Perception Drive Reality? J Surg Educ. 2012 Mar-Apr;69(2):236-40.
  22. Marks JA, Li S, Gong W, Sanati P, Eisenstadt R, Sims C, Smith DH, Reilly PM, Pascual JL. Similar Effects of Hypertonic Saline and Mannitol on Inflammation of the Blood Brain Barrier Microcirculation After Brain Injury in a Mouse Model. J Trauma Acute Care Surg. 2012 Aug;73(2):351-7.
  23. Massey PR, Sakran JV, Mills AM, Sarani B, Aufhauser DD, Sims CA, Pascual JL, Kelz RR, Holena DN. Hyperbaric oxygen therapy in necrotizing soft tissue infections. J Surg Res. Sept 2012, 177(1):146-51.
  24. Morris DS, Schweickert W, Holena D, Handzel R, Sims C, Pascual JL, Sarani B. Differences in outcomes between ICU attending and senior resident physician led medical emergency team responses. Resuscitation. 2012 Dec;83(12):1434-7.
  25. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA, Pascual JL, Reilly PM, Holena DN, Interhospital transfer: An Independent Risk Factor for Mortality in the Surgical Intensive Care Unit. Pending publication Am Surg, 2012 Dec.
  26. Holena D, Stoddard, D, Martin ND, Winters B, Casey J, Pascual J, Sims C, Sarani B, Clinical outcomes following invasive versus noninvasive preoperative stabilization of closed diaphyseal femur fractures. Eur J Trauma Emerg Surg 2012 Dec;38(6): 623-6.
  27. Grill E, Strong M, Sonnad SS, Sarani B, Pascual J, Collins H, Sims CA. Altered thyroid function in severely injured patients. J Surg Res. 2013 Jan;179(1):132-7.
  28. Sims CA, Isserman JA, Holena D, Sundaram LM, Tolstoy N, Greer S, Sonnad S, Pascual J, Reilly P. Exception from informed consent for emergency research: consulting the trauma community. J Trauma Acute Care Surg. 2013 Jan;74(1):157-65.
  29. Valdez C, Schroeder E, Amdur R, Pascual J, Sarani B. Serum creatine kinase levels are associated with extremity compartment syndrome. J Trauma Acute Care Surg. 2013 Feb;74(2):441-5.
  30. Dechert TA, Sarani B, McMaster M, Sonnad S, Sims C, Pascual JL, Schweickert WD. Medical emergency team response for the non-hospitalized patient. Resuscitation. 2013 Mar;84(3):276-9.
  31. Tolstoy NS, Aized M, McMonagle MP, Holena DN, Pascual JL, Sonnad SS, Sims CA. Mineralocorticoid deficiency in hemorrhagic shock. J Surg Res. 2013 Apr;180(2):232-7.
  32. Morris DS, Rohrbach J, Sundaram LMT, Sonnad S, Sarani B, Pascual J, Reilly P, Sims C.  Early hospital readmission in the trauma population: are the risk factors different? Accepted for publication, Injury 2013 Apr.
  33. Jacovides CL, Bruns B, Holena DN, Sims CA, Wiebe DJ, Reilly PM, Pascual JL, Penetrating Trauma In Urban Women: Patterns of Injury and Violence.  Pending publication J Surg Research 2013 Jun.
  34. Davis L, Johnson L, Greer SE, Allen SR, Kim PK, Sims CA, Pascual JL, Reilly PM, Holena DN. Practitioner Perceptions of Trauma Video Review" Pending Publication J Trauma Nursing  2013 Jun
  35. Ebbeling L, Grabo DJ, Shashaty M, Dua R, Sonnad SS, Sims CA, Pascual JL, Schwab CW, Holena DN. Psoas:lumbar vertebra index: central sarcopenia independently predicts morbidity in elderly trauma patients.Pending publication Eur J Trauma Emerg Surg 2013 Jul
  36. Pascual JL, Murcy M, Li S, Gong W, Eisenstadt R, Kumasaka K, Sims C, Smith DH, Browne K, Allen S, Baren J. Neuroprotective effects of progesterone in TBI: Blunted in vivo neutrophil activation at the blood brain barrier. Pending publication Am J Surg 2013 Jul.
  37. Kim L, Schuster J, Holena DN, Sims C, Levine J, Pascual JL. Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on brain imaging.  Submitted for publication Intl J Crit Ill Injury Sc 2013 Jul.
  38. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA, Pascual JL, Reilly PM, Holena DN, Interhospital transfer: An Independent Risk Factor for Mortality in the Surgical Intensive Care Unit. Am Surg 2013 Sept;79(9):909-13.
  39. Jacovides CL, Bruns B, Holena DN, Sims CA, Wiebe DJ, Reilly PM, Pascual JL, Penetrating Trauma In Urban Women: Patterns of Injury and Violence.  J Surg Research 2013 Sept 184(1):592-8.
Reviews in Peer Reviewed Research Publications
  1. Chughtai T, Pascual J, Partap V, Steinmetz O. Left gastric artery aneurysm: Case report and review of the literature. [Review] International Journal of Angiology 9:156-158, 2000.
  2. Pascual JL, Khwaja KA, Chaudhury P, Christou NV. Hypertonic saline and the microcirculation. [Review] Journal of Trauma-Injury Infection & Critical Care 54(5 Suppl):S133-140, May 2003.
  3. Seely AJ, Pascual JL, Christou NV. Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance. [Review] Critical Care (London) 7(4):291-307, Aug. 2003.
  4. Sarani, B, Strong, M, Pascual, JL, Schwab, CW. Necrotizing Fasciitis: Current Concepts and review of the literature, Journal of the American College of Surgeons 208(2):279-88 Feb 2009.
  5. Pascual JL, Holena D, del Portal D, Schwab CW, Blunt intrapericardial superior vena cava injury – A trap for the unwary. Injury Extra 41:4–6, Jan 2010.
Research Publications, Non-Peer Reviewed
  1. Seely A, Naud J-F, Campisi G, Pascual J, Ferri L, Christou N. Dynamic alteration of neutrophil chemoattractant receptors regulates neutrophil chemotaxis in humans in vivo. Owen H. Wangensteen Surgical Forum LII: 2001.
  2. Ferri L, Pascual J, Seely A, Christou N. Intra-abdominal sepsis attenuates inflammation mediated increases in microvascular permeability at remote sites. Owen H. Wangensteen Surgical Forum LII: 2001.
Abstracts
  1. Pascual JL, Maloney E, Reilly PM, Keutmann MK, Stein S, Leroux PD, Gracias VH.  The effect of an institutional pathway on TBI resuscitation with 7.5% hypertonic saline.  Oral paper at the 36th Western Trauma Association Scientific Meeting, Big Sky, MT, March 2006. Journal of Trauma 60(1):250, 2006.
  2. Pascual JL, Ferri L, Khwaja K, Giannias B, Evans D, Michel R, Christou N.  Hypertonic saline in hemorrhagic shock blunts tissue injury independent of its ability to block neutrophil-endothelial adhesion. Oral paper at the Joint Meeting of the Trauma Association of Canada & Pan-American Trauma Society, Banff, Alberta, March 2006.  Journal of Trauma 60(2):464, 2006.
  3. Pascual J, Chovanes J, Waring S, Reilly P. The evolving use of CT scanning in the trauma bay of a large academic Level I trauma center. Oral paper at the 10th Annual Pennsylvania Committee on Trauma, Harrisburg, PA, October 2006.
  4. J Pascual, J Chovanes, S Waring, P Reilly, CW Schwab. The use of total body CT scanning in the initial evaluation of injured patients reduces trauma patient admissions. Oral paper at the 42nd World Congress of Surgery of the International Surgical Society, Montréal, Canada, August 2007.
  5. Sims C, Jaffe R, Foreman J, Menger R, Sonnad S, Pascual J, Sarani B.  Adrenal insufficiency in hemorrhagic shock. Poster at the 37th Congress of the SCCM, Honolulu, HI. Crit. Care Med 2008:36(12):A65.
  6. Kim P, Pryor JP, Schwab CW, Podgorski AM, McMaster J, Rohrbach J, Gracias V, Braslow B, Sarani B, Sims C, Pascual JL, Reilly PM. Attendings matter: re-focusing on trauma inpatients improves outcomes and patient satisfaction. Poster at the 2008 AAST Scientific Meeting, Pittsburgh, PA.
  7. Powell E, Sarani B, Taddeo J, Carr B, Seamon M, Goldberg A, Pascual JL, Schwab CW. A comparison of operation and transcatheter arterial embolization for the treatment of blunt renal injury. Oral paper at the 2009 AAST Scientific Meeting, Phoenix, AZ.
  8. Pascual JL, Ding W, Sarani B, Peterson J, Horan A, Abdurraheim N, Aized M, Sims C, Gracias V, Schwab CW. Hypertonic saline in the ICU worsens neutrophil respiratory burst despite reducing adhesion receptor expression. Poster at the 38th Congress of SCCM, Miami Beach, FL, Crit. Care Med 37(12); A63, Dec 2009.
  9. Sims C, Aized M, Abdurraheim N, Aziz M, Sarani B, Pascual J. Relative adrenal insufficiency: The impact of hemorrhagic shock. Poster at the 38th Congress of SCCM, Miami Beach, FL, Crit. Care Med 37(12);A1-A542, Dec 2009.
  10. Sarani B, Keeney S, Schweickert W, Palilonis E,  Myers J, Phillips J, Sonnad S, Bergey M, Sims C, Pascual JL. Differences between medical and surgical patients. Evaluated by a medical emergency team (MET) Poster at the 38th Congress of SCCM, Miami Beach, FL, Crit. Care Med 37(12);A1-A542, Dec 2009.
  11. Sarani B, Dechert T, McMaster M, Schweickert W, Sonnad S, Fitzpatrick MK, Sims C, Pascual J. Medical emergency team (MET) response in the nonhospitalized patient. Poster at the 38th Congress of SCCM, Miami Beach, FL, Crit. Care Med 37(12);A1-A542, Dec 2009.
  12. D Sabra, M Bergey, E Grill, B Sarani, J Pascual, E Datner, C Sims. Intimate partner violence and the trauma team: more than education is needed. Poster at the 5th Annual Academic Surgical Congress Feb 3-5, 2010 San Antonio, TX, J Surg Res 158(2):171-442 Feb 2010.
  13. Ding W, Sims C, Horan A, Sarani B, Schwab W, Pascual JL. Hypertonic saline in the ICU reduces inflammation and increases shedding of receptors responsible for microcirculatory inflammation. Oral paper at the 8th World Congress on Trauma, Shock, Inflammation and Sepsis. Munich, Germany. Inflamm Res.59(S1):S138. 2010.
  14. Pascual J, Rosen P, Horan A, Sarani B, Sims C, Schwab CW. Hypertonic Fluids in SICU Shock Patients Reduce Fluid and Oxygen Requirements Shock. Poster presented at the 33rd Conference on Shock, Portland, ON, Shock 2010;33(1):78.
  15. Rosenbloom J, Guan Y, Sawey E, Becker L, Sarani B, Pascual J, Sims C. Posterior pituitary exhaustion in hemorrhagic shock and resuscitation. Paper presented at the 33rd Conference on Shock, Portland, ON, Shock 2010;33(1):38.
  16. Pascual JL, Georgoff P, Horan A, Sims C, Sarani B, Stiefel M, LeRoux P, Schwab CW. Brain tissue hypoxia in traumatic brain injury: are most commonly used interventions successful at correcting brain tissue oxygen deficits? Oral paper at the 2010 AAST Scientific Meeting, Boston, Ma, (http://www.aast.org ) P16.
  17. Pascual JL, McNicholas A, Bridges A, Sims CA, Sarani B, Fernandez F, Schwab CW. The effects of instituting a hospital guideline to reverse the coagulopathy of Plavix (Clopidogrel) in traumatic brain injury patients. Poster at the 2010 AAST Scientific Meeting, Boston, Ma, (http://www.aast.org )P53.
  18. Sims CA, Guan Y, Rosenbloom J, Pascual JL, Sarani B, Becker L, Reilly PM, Schwab CW. Resuscitation of hemorrhagic shock with vasopressin restores liver cytochrome oxidase activity. Poster at the 2010 AAST Scientific Meeting, Boston, Ma, (http://www.aast.org ) P111.
  19. Taddeo, J, Pascual, JL, Cheung, A, Schwab, CW. Systolic Anterior Motion in Traumatic Shock.  Video Presentation at 96th Annual Clinical Congress of the American College of Surgeons, Washington, DC, October 2010.
  20. DS Morris, JI Rohrbach, MP Rogers, M Sundaram, SS Sonnad, JL Pascual, B Sarani, CA Sims. The Surgical Revolving Door: Who Gets Readmitted To The Hospital? 6th Annual Academic Surgical Congress, Huntington Beach, CA, J Surg Res 165(2):333, 2011.
  21. J Sakran, B Finneman, C Maxwell, S Sonnad, B Sarani, JL Pascual, CA Sims. Trauma Leadership: Does Perception Drive Reality? Oral at 6th Annual Academic Surgical Congress, Huntington Beach, CA. J Surg Res 165(2):243, 2011.
  22. Gong W, Sanati P, Marks J, Sarani B, Sims C, Pascual JL. Hypertonic saline resuscitation of hemorrhagic shock increases in vivo neutrophil interactions with endothelium in the blood brain microcirculation. Oral paper at the 2011 EAST Scientific Meeting, Naples, FL.
  23. Pascual JL, Vella M, Holena DH, Sicoutris C, Chandrakaladharan B, Fox A, Sarani B, Sims C, Williams N, Schwab CW. Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit. Oral paper at the 2011 EAST Scientific Meeting, Naples, FL.
  24. Impact of the Repeal of the Pennsylvania Mandatory Motorcycle Helmet Law on Traumatic Head Injuries at an Urban Trauma Center. Oral paper at Pennsylvania Neurosurgical Society’s 98th Scientific Meeting, Hershey, PA, July 2011.
  25. Bruns B, Taddeo J, Bassett G, Pascual JL, Holena DN, Sonnad S, Reilly P, Schwab CW, Sims CA. Seeking closure: a pilot study of a novel dynamic fascial closure technique following damage control laparotomy. Poster at the 2011 AAST Scientific Meeting, Chicago, IL, (http://www.aast.org)P18.
  26. Morris DS, Rohrbach J, Sonnad S, Sarani B, Pascual JL, Reilly P, Sims CA. Early hospital readmission in the trauma population: are the risk factors different? Poster at the 2011 AAST Scientific Meeting, Chicago, IL, (http://www.aast.org) P89.
  27. Pascual JL, Fang P, Sarani B, Sims C, Schwab CW. The steadily increasing incidence and lethality of penetrating brain injury: a single trauma bay GCS point drop increases mortality. Poster at the 2011 AAST Scientific Meeting, Chicago, IL, (http://www.aast.org) P120.
  28. Holena D, Sims C, Kim P, Pascual J, Sarani B, Sonnad S, Braslow B, Reilly P, Schwab W. Blood Product Ratios and Massive Transfusion: Lowering Mortality at the Cost of Morbidity. Oral paper at 97th Annual ACS Clinical Congress. San Francisco, CA.
  29. Marks J, Li S, Gong, W, Sanati P, Eisenstadt R, Sims C, Sarani, B, Pascual JL. In vivo inflammation of the blood brain barrier microcirculation after TBI: HTS is not superior to mannitol. Oral paper at the 2012 EAST Scientific Meeting, Lake Buena Vista, FL.
  30. Morris D, Schweickert W, Handzel R, Holena D, Sims C, Pascual JL. Is the attending physician necessary at rapid response activations? Poster at the 41st Congress of SCCM, Houston, TX, Crit. Care Med 39(12) (Sup):p121 Dec 2011.
  31. Li S, Marks J,  Sanati P, Eisenstadt R, Gong W, Browne K, Smith D, Becker L, Pascual JL. In vivo evolution of microvascular inflammation after traumatic brain injury: an intravital microscopy study. Oral paper at the 41st Congress of SCCM, Houston, TX, Crit. Care Med 39(12) (Sup):p1 Dec 2011.
  32. Grabo DJ, Holena DN, Sakran JV, Braslow BM, Pascual JL, Reinke CE, Reilly PM, Schwab CW, Kelz RR. Understanding risk in emergency abdominal surgery in our elders. Quickshot at the 7th Annual Academic Surgical Congress, Las Vegas, NV. J Surg Res 172(2):199, 2012.
  33. Tolstoy NS, Aized MT, McMonagle MP, Holena DN, Pascual JL, Sonnad SS, Sims CA. Mineralocorticoid deficiency in hemorrhagic shock. Quickshot at the 7th Annual Academic Surgical Congress, Las Vegas, NV, J Surg Res 172(2):346, 2012.
  34. Fang P, Holena DN, Weibe D, Kim P, Sims CA, Sarani B, Schwab CW, Pascual JL. Organ donation rates remain stagnant despite the steadily rising incidence and lethality of penetrating brain injury. Quickshot at the 7th Annual Academic Surgical Congress, Las Vegas, NV, Jf Surg Res 172(2):348, 2012.
  35. Marks JA, Hurd JR, McNicholas A, Sims CA, Sarani B, Schwab CW, Pascual JL. Delay in blood product transfusion in TBI patients on clopidogrel or warfarin worsens neurologic outcome. Quickshot at the 7th Annual Academic Surgical Congress, Las Vegas, NV, J Surg Res 172(2):348, 2012.
  36. Li S, Marks J, Murcy M, Sanati P, Eisenstadt R, Gong W, Holena D, Sims C, Smith D, Zhang J, Pascual J. Curcumin reduces microvascular inflammation following traumatic brain injury – A live animal study. Poster at the Neurotrauma 2012 Congress, Phoenix, AZ, J Neurotrauma 29(10):A13 July 2012.
  37. Sims C, Isserman J, Sundaram L, Tolstoy N, Greer S, Pascual JL, Reilly P. Exception from informed consent for emergency research: consulting the trauma “community”. Oral paper at the 2012 AAST Scientific Meeting, Kauai, HI, (http://www.aast.org ) P 72.
  38. Valdez C, Schroeder E, Pascual JL, Amdur R, Sarani B. Association between creatinine kinase and compartment syndrome. Oral paper at the 2012 AAST Scientific Meeting, Kauai, HI, (http://www.aast.org )P 73.
  39. Gallesio JM, Holena D, Huang J, Sims C, Levine J, Ying GS, Pascual JL. Hypertonic saline is superior to mannitol in severe traumatic brain injury for hourly correction of ICP, CPP but not brain oxygenation. Poster at the 2012 AAST Scientific Meeting, Kauai, HI, (http://www.aast.org )P43.
  40. Arthur K, Kelz R, Robertson M, Sims CA,  Pascual JL, Reilly P, Holena DH, Interhospital transfer: An independent risk factor for mortality in the surgical intensive care unit. Oral at the ACS Surgical Forum, Chicago, IL, JACS 215(3 Sup):S51, Sept 2012.
  41. Kim L, Schuster J, Holena DN, Sims C, Levine J, Pascual JL. Is early initiation of prophylactic heparin in severe traumatic brain injury neuroprotective? Oral at the ACS Surgical Forum, Chicago, IL, JACS 215(3 Sup):S54, Sept 2012.
  42. McCunn M, Vavilala M, Dutton R, Sims C, Pascual J. Anesthesiologists’ management of unstable trauma patients differs from accepted trauma surgical guidelines. Poster at the 42nd Congress of SCCM, San Juan, PR, Crit. Care Med 40(12) (Sup1):p1-328 Dec 2012.
  43. M Gupta, C Reinke, J Myers, R Kelz, J Pascual. Extending the principles of procedural certification to patient safety: a satisfying surgical handoff curriculum. Quickshot at the 8th Annual Academic Surgical Congress, New Orleans, LA, J Surg Res 179(2): 188.
  44. V Sant, R Cheney, D Holena, B Braslow, J Pascual, P Reilly, S Allen. Trauma recidivism: short time to reinjury calls for early and aggressive violence prevention and intervention. Quickshot at the 8th Annual Academic Surgical Congress, New Orleans, LA, J Surg Res 179(2): 345.
  45. A Schwed, S Sonnad, D Holena, JL Pascual, P Reilly, C Sims. Take a deep breath!: managing rib fractures in elderly trauma patients. Quickshot at the 8th Annual Academic Surgical Congress, New Orleans, LA, J Surg Res 179(2): 346.
  46. R Eisenstadt, R Sensenig, D Holena, C Sims, B Braslow, J Pascual. Dislodged surgical feeding tubes: should we abandon bedside contrast abdominal KUB's in favor of CT. Quickshot at the 8th Annual Academic Surgical Congress, New Orleans, LA, J Surg Res 179(2): 339.
  47. C Jacovides, B Bruns, D Holena, C Sims, PM Reilly, JL Pascual. Penetrating injuries in urban female patients: worrisome trends outside our social radar? Oral paper at the 8th Annual Academic Surgical Congress, New Orleans, LA, J Surg Res 179(2):274.
  48. Pascual JL, Murcy MA, Li S, Gong W, Eisenstadt R, Kumasaka K, Sims C, Smith DH, Browne K, Allen S, Baren J. Neuroprotective effects of progesterone in TBI: Blunted in vivo neutrophil activation at the blood brain barrier. Oral presentation at Southwestern Surgical Congress 2013 –submitted for publication to AJS
  49. Lane-Fall M, Spivey JR, Mullen-Fortino M, Kohl BA, Reilly PM, Pascual JL, Novel integration of critical event video review for performance improvement in the intensive care unit. Poster at the Academy for Healthcare Improvement's 2013 Conference, Arlington VA, April 2013.
  50. Gong W, LI S, Kumasaka K, Smith DH, Murcy MA, Sims CA, Allen S, Pascual JL. Type of fluid resuscitation fluid alters BBB inflammation a day after shock: an in vivo cerebrovascular study.  Poster at 36th Annual Conference of Shock Society 2013, San Diego, CA.
  51. Kumasaka K, Murcy M, Gong W, Browne K, Li s, Sims, C, Allen S, Smith, DH, Pascual JL. Osmotherapy in repeated doses alters ongoing blood brain barrier PMN-mediated inflammation after TBI. Poster at Neurotrauma 2013 Symposium, Nashville, TN. Aug 2013
  52. Eisenstadt R, Sanati-Mehrizy P, Gong W, Murcy MA, Kumasaka K, Sims CA, Allen SR, Becker LB, Pascual JL. Development of a rodent model of repeated immunemodulating resuscitation for sepsis allows delayed in vivo evaluation of the microcirculation. Poster at 36th Annual Conference of Shock Society 2013. San Diego, CA.
  53. Blank N, Holena DN, Robertson M, Diop M, Allen SR, Martin N, Sims C, Reilly PM, Pascual JL. Surgical ICU patients boarding in other ICUs: greater distances equal more frequent complications. Oral paper at the 2013 AAST Scientific Meeting, San Francisco, CA.
  54. Bohman, L-E, Holmes J, Pascual JL, Stein S, The Impact of the Repeal of Pennsylvania’s Mandatory Motorcycle Helmet Law on Helmet Use and Head Injury: A Study of Two Urban Trauma Centers On Opposite Sides of the State Line" Oral paper at the 2013 Congress of Neurological Surgeons Annual Meeting, San Francisco, CA, (http://w3.cns.org).
Editorials, Chapters & Participation in Committee Reports
  1. Pascual JL, Sarani B, Schwab CW.  ACS criteria for surgeon presence at initial trauma resuscitations: Superfluous or necessary? [Commentary] Annals of Emergency Medicine 50(1):15-7, Jul. 2007. (Epub  Dec 2006.)
  2. Pascual JL, Sarani B, Schwab CW.  Are surgeons superfluous to initial major trauma resuscitations? [Second commentary] Annals of Emergency Medicine 51(3):335-8, March 2008.
  3. JL Pascual, VH Gracias, PD LeRoux. Injury to the Brain. In: Flint, Meredith, Schwab et al eds. Trauma: Contemporary Principles and Therapy. 1st ed. Philadelphia: Lippincott Williams & Wilkins; pp275-88, 2008.
  4. JL Pascual, VH Gracias. Damage Control Surgery [Control de Daños]. In: Machado AJ, Aguilera SL, eds. Emergencias. 1st ed. Azcuenaga. Argentina: Edimed-Ediciones Medicas SRL; 673-678, 2008.
  5. Jin H. Ra, Jose L. Pascual, C. William Schwab. Septic Response in Current Surgical Therapy, Elsevier Mosby 10th ed. Philadelphia, PA:  Ed. Cameron, J.L. 2011.
  6. Scott Keeney, Jose L. Pascual. Abdominal Trauma in The Intensive Care Unit Manual, Elsevier Saunders 2nd ed. Philadelphia, PA:  Eds. Lanken, Hanson, Manaker (in press).
  7. Edgardo Salcedo, Jose L. Pascual. Fluid Management in Traumatic Brain Injury in Encyclopedia of Intensive Care Medicine, Heidelberg, Germany: Eds Vincent, Hall (in press).
  8. Kofke A, Horak J, Stiefel M, Pascual J. Viable Oxygenation with Cannula-Over-Needle Cricothyrotomy for Asphyxial Airway Occlusion Letter to the Editor. The British Journal of Anaesthesia 107: 642-3, Sept 2011.
  9. JL Pascual, B Jackson, S Moulik, MHU Usman. Deep Venous Thrombosis with Phlegmasia Cerulea Dolens. In: Atlas of Vascular Medicine – ER Mohler, HI Litt eds. A Case Based Approach to Current Management 1st ed. New York: Demos Medical, 2012.
  10. JL Pascual, J Horak, VH Gracias, PJ Neligan. Volume status and cardiac function. In: LeRoux PD, Levine JM, Kofke WA, eds. Monitoring in Neurocritical Care. 1st ed. Philadelphia: Elsevier; 2013.pp176-88.
 
Awards, Honors and Membership in Honorary Societies:
2006   Best Basic Science Paper Presentation, Joint Meeting of the Trauma Association of Canada and the Pan-American Trauma Society Annual Scientific Meeting, Banff, Alberta
 
2006 Recipient of theFrank McGill Traveling Fellowship from the McGill University Department of Surgery ($10 000)
 
2006 Recipient of the Whittall Armour Traveling Fellowship from the McGill University Department of Surgery ($10 000)
 
2002 Best Oral Presentation, Trauma Association of Canada Annual Scientific Meeting, Whistler, British Columbia
 
2002 Recipient of 1st prize at 7th Annual H. Rocke Robertson Resident Trauma Research Day
 
2001 Invited panelist at the 2nd Molson Medical Informatics Symposium
 
2001 Recipient of 2001 Surgical Specialty Award for “…excellence in critical care research…” Abstract presented at the 2001 Society of Critical Care Medicine meeting, San Francisco, CA
 
2001  Recipient of 1st prize at 6th Annual H. Rocke Robertson Resident Trauma Research Day
 
2000 Recipient of 2nd prize at 11th Annual Fraser Gurd Day (Resident Research Day)
 
2000  Recipient of the Brigadier-General Herbert Stanley Birkett Fellowship (The Royal Victoria Hospital Research Institute)
 
2000  Recipient of the Surgical Infection Fellowship Award 2000 (Surgical Infection Society) ($40 000)
 
1996 AE Award “Most Influential Member of Student Body”
 
1995 Cited for highest Surgical Anatomy knowledge in core surgical rotation
 
1993 - 1995 Aesculapian Society [Faculty of Medicine Students’ Association]; President (1994-95), Executive Vice President (1993-94).
 
1993 - 1994 Health Sciences Campus Commissioner
 
1993 Recipient of MRC Summer Student Research Scholarship entitled: “The Effect of ACE Inhibition and AII Antagonism on Ischemic and Reperfusion Damage of the Heart,” University of Ottawa Heart Institute
 
1993 Ames Prize: Highest Academic Standing of Class in Hematology Course
 
1992 - 1993 Class of ‘96 - Internal Vice President
 
1991 - 1992 A+ Merit Scholarship
 
1990 - 1991 A+ Merit Scholarship
 
1990 - 1992 Cited on Faculty of Science Dean’s List
 
1989 - 1990 Director of External Events, Gardener Hall Residence, McGill University
 
1989 University of Ottawa Entrance Scholarship ($1000)

Dr. Jose Pascual

 
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