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Carrie A. Sims, M.D.
Traumatology, Surgical Critical Care and Emergency Surgery

 
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Administrative Office:
Hospital of the University of Pennsylvania
3400 Spruce Street, 5035 Maloney
Philadelphia, PA 19104
Administrative Assistant: Myra Rodriguez
Administrative Telephone: 215-662-7323
Administrative Fax: 215-349-5917

Clinical Office:
The Trauma Center at Penn
3400 Spruce Street, 2 Dulles
Philadelphia, PA 19104
Clinical Telephone: 215-662-7320
Clinical Fax: 215-614-0375

Contact Information (internal use only)

carrie.sims@uphs.upenn.edu

 

Dr. Sims completed her surgical training at the Massachusetts General Hospital in 2003. She was appointed as Instructor of Surgery at Harvard Medical School (2003-2004) and completed a fellowship in Laparoscopic Surgery in 2004. She subsequently trained at the Hospital of the University of Pennsylvania and completed a fellowship in Traumatology and Surgical Critical Care. She is board certified in General Surgery and Surgical Critical Care.

Dr. Sims is currently an Assistant Professor of Surgery at the University of Pennsylvania School of Medicine and is the Medical Director for the Dulles 6 Surgical Unit and a unit-based clinical leader. Her clinical projects include an observational study investigating the neuroendocrine profile of trauma patients undergoing massive resuscitation, the use of hormonal supplementation in trauma, and the implementation of a domestic violence screening tool in the trauma bay. Her laboratory is investigating mitochondrial dysfunction in late stage hemorrhagic shock and the development of targeted resuscitative solutions. (AVERT Shock Trial)

 
Faculty Appointments
2003 - 2004 Instructor in Surgery, Department of Surgery
Harvard Medical School
Boston, Massachusetts
 
2004 - 2006 Instructor in Surgery, Department of Surgery
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
2006 - present Assistant Professor of Surgery at HUP
Perelman School of Medicin
Philadelphia, Pennsylvania
 
Hospital and Administrative Appointments
1989 - 1990 Resident Assistant, Stanford University
Stanford, California
 
1991 Human Physiology Teaching Assistant
University of California, Berkeley, California
 
1991 - 1995 Suitcase Clinic, a student-run free clinic for the homeless in Berkeley, California
Physician Coordinator (1991-1992)
Medical Co-Director (1992-1993)
 
1992 Anatomy Prosectionist, University of California
Berkeley, California
 
1993 Histology Teaching Assistant
University of California, Berkeley, California
 
1998 - 2001 ATLS Laboratory Teaching Assistant, Massachusetts General Hospital
Boston, Massachusetts
 
1998 - 2001 Tenum Locums, Shriner’s Burns Institute
Boston, Massachusetts
 
1999 - 2001 Surgical Consult, Spaulding Rehabilitation Hospital
Boston, Massachusetts
 
2004 - 2006 Tenem Locums, Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
 
2005 - present Attending Surgeon, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2006 - 2009 Medical Director, Dulles 6 Surgical Floor, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2006 - present Attending Surgeon, Reading Hospital
Reading, Pennsylvania
 
2009 - present Unit Based Clinical Leader, Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania
 
2009 - 2011 Research Conference Coordinator, Division of Traumatology
Surgical Critical Care and Emergency Surgery
   
2011- present Research Director, Division of Traumatology
Surgical Critical Care and Emergency Surgery
 
Education/Training
1986 - 1990 B.A. Stanford University
(Departmental Honors, Human Biology)
 
1990 - 1993 M.S. School of Public Health
University of California, Berkeley
(Health and Medical Science)
 
1990 - 1995 M.D. University of California, San Francisco
 
Postgraduate Training and Fellowship Appointments
1998 – 1999 Surgical Research Fellow
Beth Israel Medical Center, Boston, MA
Investigated ischemia-reperfusion injury
sepsis and oxygen utilization
(Mentor: Dr. Mitchel Fink)
 
1999 – 2001 Surgical Research Fellow
Harvard Center for Minimally Invasive Surgery
Boston, Massachusetts
Investigated minimally-invasive techniques
of monitoring hemorrhagic shock
(Mentor: Dr. Juan Carlos Puyana)
 
1995 - 1996 Intern in Surgery
Massachusetts General Hospital
Boston, Massachusetts
 
1996 - 2003 Resident in Surgery
Massachusetts General Hospital
Boston, Massachusetts
 
2003 - 2003 Chief Resident in Surgery
Massachusetts General Hospital
Boston, Massachusetts
 
2004 - 2004 Fellowship, Laparoscopic Surgery
Massachusetts General Hospital
Boston, Massachusetts
 
2004 - 2006 Fellowship, Trauma and Surgical Critical Care
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
 
Military Service
2001 – 2010 Major, United States Army Reserves
 
July 2006 - Oct 2006 Operation Enduring Freedom
Tripler Army Medical Center, Hawaii
 
Feb 2009 - June 2009 Operation Enduring Freedom
Walter Reed Medical Center
Washington, DC
 
Memberships/Societies
1992 - 1995 American Medical Students Association
Pharmaceutical Study Group, 1992-1993
Board of Trustees, 1993-1994
Associate Trustee, 1994-1995
 
1999 - present Society of Critical Care Medicine
 
2007 - present Eastern Association for the Surgery of Trauma
 
2007 - present Shock Society
 
2008 - present Association for Academic Surgery
 
2008 - present American College of Surgeons, Fellow
 
2009 - present Mitochondrial Physiology Society
 
2009 - present American Association for the Surgery of Trauma
 
Local/Regional Societies
2004 - present Massachusetts General Hospital Surgical Society
 
2010 - present Philadelphia Academy of Surgery
 
Scientific Committees
2007 - present Center for Resuscitation Science
University of Pennsylvania
 
2008 - present Mitochondrial Interest Group
Children’s Hospital of Philadelphia
 
Research
Dr. Sims research interests include hemorrhagic shock, novel resuscitative strategies, traumatic brain injury, and the endocrinology of trauma and critical illness. Her clinical projects include an observational study investigating the neuroendocrine profile of trauma patients undergoing massive resuscitation, the use of hormonal supplementation in trauma, and the implementation of a domestic violence screening tool in the trauma bay. Her laboratory is investigating mitochondrial dysfunction in late stage hemorrhagic shock
 
AVERT Shock
 
 
 
 
Publications
Research Publications, Peer Reviewed
  1. Legome EL, Sims C, Rao P. Epiploic appendagitis: adding to the differential diagnosis of abdominal pain. Journal of Emergency Medicine 17(5):823-826, Sept./Oct. 1999.
  2. Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP. Ringer’s ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Critical Care Medicine 29(8):1513-1518, Aug. 2001.
  3. Sims C, Seigne P, Menconi M, Pettit J, Puyana JC. Skeletal muscle acidosis correlates with the severity of blood volume loss during shock and resuscitation. Journal of Trauma 51(6):1137-1146, Dec. 2001.
  4. Sims CA, Berger D. Airway risk in hospitalized patients with cervical spine injuries requiring halo fixation. Annals of Surgery 235(2):280-284, Feb. 2002.
  5. Sims C, Stylopoulos N, Clavijo J, Barlow C. Histologic characteristics of laparoscopic saline-enhanced electrosurgery of liver and splenic injuries. Surgical Endoscopy 17(11):1739-1743, Nov. 2003.
  6. Marshburn TH, Legome E, Sargsyan A, Li J, Noble, VA, Dulchavsky SA, Sims C, Robinson D. Goal-directed ultrasound in the detection of long-bone fractures. Journal of Trauma 57(2):329-332, Aug. 2004.
  7. Clavijo-Alvarez JA, Sims CA, Menconi M, Shim I, Ochoa C, Puyana JC. Bladder mucosa pH and pCO2 as a minimally invasive monitor of hemorrhagic shock and resuscitation. Journal of Trauma 57(6):1199-1210, Dec. 2004.
  8. Clavijo-Alvarez JA, Sims CA, Pinsky MR, Puyana JC. Monitoring skeletal muscle and subcutane-ous tissue acid-base status and oxygenation during hemorrhagic shock and resuscitation. Shock 24(3):270-275, Sept. 2005.
  9. Sims CA, Wiebe DJ, Nance ML.  Blunt solid organ injury: Do adult and pediatric surgeons treat children differently? Journal of Trauma 65(3):698-703, Sept. 2008.
  10. Nagpal S, Halpern CH, Sims C, Gracias VH, Schuster JM, LeRoux PD, Levine JM. Decompressive laparotomy to treat intractable cerebral hypoxia. Journal of Trauma 67(5):E152-155, Nov. 2009.
  11. Sarani B, Temple-Lykens B, Kim P, Sonnad S, Bergey M, Pascual JL, Sims C, Schwab CW, Reilly P. Factors associated with mortality and brain injury after falls from the standing position. Journal of Trauma 67(5):954-958, Nov. 2009.
  12. Plackett TP, Coviello LC, Belnap CM, Phillips KJ, Sims CA. Intussusception and colonic ischemia in portal hypertension: a case report. Hawi’i Medical Journal 69(2):39-41, Feb. 2010.
  13. Sarani B, Palilonis E, Sonnad S, Bergey M, Sims C, Pascual J, Schweickert W. Clinical emergencies and outcomes in patients admitted to a surgical versus medical service. Resuscitation 82(4):415-418, Apr. 2011 (Epub Jan. 16, 2011).
  14. Sims CA, Sabra D, Bergey M, Grill E, Sarani B, Pascual J, Datner E, Kim P. Detecting intimate partner violence and the trauma team: more than education is needed. JACS 212(5):867-872, May 2011 (Epub Mar. 16, 2011).
  15. Pascual J, Georgoff P, Maloney E, Sims C, Sarani B, Stiefel M, LeRoux P, Schwab CW. Reduced brain tissue oxygenation in traumatic brain injury: Are most commonly used interventions successful? Journal of Trauma 70(3):535-546, Mar. 2011.
  16. Sarani B, Palilonis E, Sonnad S, Bergey M, Sims C, Pascual J, Schweickert W. Clinical emergencies and outcomes in patients admitted to a surgical versus medical service. Resuscitation 2011; 82:415-8, April 2011.
  17. Sarani B, Powell E, Taddeo J, Carr B, Patel A, Seamon M, Wobb J, Sims C, Pascual J, Schwab CW. A contemporary comparison of surgical and interventional management arteriography of blunt renal injury. Journal of Vascular & Interventional Radiology 22(1):723-728, May 2011.
  18. Morris DS, Rohrbach J, Rogers M, Sundaram LMT, Sonnad S, Pascual J, Sarani B, Reilly P, Sims C. The surgical revolving door: Risk factors for hospital readmission. Journal of Surgical Research 170(2):297-301, Oct. 2011 (Epub May 19, 2011).
  19. Gong W, Marks JA, Sanati P, Sims C, Sarani B, Smith DH, Pascual JL.  Hypertonic saline resuscitation of hemorrhagic shock does not decrease in vivo neutrophil interactions with endothelium in the blood-brain microcirculation.  Journal of Trauma 71(2):275-281, Aug. 2011.
  20. Pascual JL, Holena DN, Vella MA, Palmieri J, Sicoutris C, Selvan B, Fox AD, Sarani B, Sims C, Williams NN, Schwab CW. Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit. Journal of Trauma 71(2):330-337, Aug. 2011.
  21. Menger R, Telford G, Kim P, Bergey MR, Foreman J, Sarani B, Pascual J, Reilly P, Schwab CW, Sims CA. Complications following thoracic trauma managed with tube thoracosotomy. Injury 43(1):46-50, Jan. 2012 (Epub Aug. 11, 2011).
  22. Pascual JL, Ding W, Sims C, Sarani B, Horan A, Schwab W. Hypertonic saline resuscitation of hemorrhagic shock does not decrease in vivo neutrophil interactions with endothelium in the blood-brain microcirculation. Jounal of Trauma 71:275-28, Aug.2011.
  23. Sakran JV, Finneman B, Maxwell C, Sonnad S, Sarani B, Pascual J, Schwab CW, Sims C. Trauma leadership: does perception drive reality? Journal of Surgical Education 69(2):236-240, Mar./Apr. 2012 (Epub Nov. 15, 2011).
  24. Morris DS, Reilly P, Rohrbach J, Telford G, Kim P, Sims CA. The influence of unit-based nurse practitioners on hospital outcomes and readmission rates for trauma patients. Journal of Trauma & Acute Care Surgery 73(2):474-478, Apr. 2012
  25. Morris D, Schweickert W, Holena D, Handzel R, Sims C, Pascual J.L, Sarani B. Differences in outcomes between ICU attending and senior resident physician led medical emergency team responses. Journal of Surgical Research 83(12):1434-1437, Dec. 2012 (Epub July 24, 2012)
  26. Georgoff P, Perales P, Laguna B, Holena D, Reilly P, Sims CA. Colonic injuries and the damage control abdomen: Does strategy matter? Journal of Surgical Research 181(2):293-299, May 2013 (Epub July 25, 2012).
  27. Marks J.A, Li S, Gong W, Santi P, Eisenstadt R, Sims C, Smith D.H, Reilly P, Pascual, JL.  Similar effects of hypertonic saline and mannitol on inflammation of the blood brain barrier microcirculation after brain injury in a mouse model.  Journal of Trauma & Acute Care Surgery 73(2):351-357, Aug. 2012.
  28. Grill E, Strong M, Sonnad S.S, Sarani B, Pascual J., Collins H, Sims CA.  Altered thyroid function in severely injured patients. Journal of Surgical Research 179(1):132-137, Jan. 2013 (Epub Sept. 26, 2012).
  29. Holena D, Stoddard D, Martin ND, Winters B, Casey J, Pascual J, Sims C, Sarani B. Clinical outcomes following invasive versus noninvasive preop stabilization of closed diaphyseal  femur fractures. European Journal of Trauma & Emergency Surgery 38(6):623-626, Dec. 2012.
  30. Sims C, Greer S, Holena D, Isserman J, Pascual J, Reilly P, Sonnad S, Sundaram LM, Tolostoy N. Exception from informed consent for emergency research: Consulting the trauma community. Journal of Trauma & Acute Care Surgery 74(1):157-166, Jan. 2013.
  31. Dechert TA, Sarani B, McMaster JM, Sonnad S, Sims C, Pascual JL, Schweickert WD. Medical emergency team response for the non-hospitalized patient. Resuscitation 84(3):276-279, 2013 (Epub July 6, 2012).
  32. Morris DS, Rohrbach J, Sundaram LM, Sonnad S, Sarani B, Pascual J, Reilly P, Schwab CW, Sims C.  Early hospital readmission in the trauma population: Are the risk factors different? Injury 45(1):56-60, Jan. 2014 (Epub May 29, 2013).
  33. Villarroel JP, Guan Y, Werlin E, Selak MA, Becker LB, Sims CA.  Hemorrhagic shock and resuscitation are associated with peripheral blood mononuclear cell mitochondrial dysfunction and immunosuppression. Journal of Trauma Acute Care Surgery 75(1):24-31, July 2013.
  34. Jacovides CL, Bruns B, Holena DN, Sims CA, Wiebe DJ, Reilly PM, Pascual JL.  Penetrating trauma in urban women: Patterns of injury and violence.  Journal of Surgical Research 184(1):592-598, Sept. 2013 (Epub July 3, 2013).
  35. Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA.  Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.  Aging (Albany NY) 5(7):539-550, July 2013.
  36. Davis L, Johnson L, Allen SR, Kim PK, Sims CA, Pascual JL, Holena DN.  Practitioner per-ceptions of trauma video review.  Journal of Trauma Nursing 20(3):150-154, July-Sept. 2013.
  37. Arthur KR, Kelz RR, Mills AM, Reinke CE, Robertson MP, Sims CA, Pascual JL, Reilly PM, Holena DN.  Interhospital transfer: an independent risk factor for mortality in the surgical intensive care unit.  American Surgeon 79(9):909-913, Sept. 2013.
  38. Benns M, Carr B, Kallan MJ, Sims CA. Benchmarking the incidence of organ failure after injury at trauma centers and nontrauma centers in the United States.  Journal of Trauma & Acute Care Surgery 75(3):426-431, Sept. 2013.
  39. Villarroel JPP, Figueredo R, Guan Y, Tomaiuolo M, Karamercan MA, Welsh J, Selak MA, Becker LB, Sims C.  Increased platelet storage time is associated with mitochon-drial dysfunction and impaired platelet function.  Journal of Surgical Research 184(1):422-429, Sept. 2013.
  40. Pascual JL, Murcy MA, Li S, Gong W, Eisenstadt R, Kumasaka K, Sims C, Smith DH, Browne K, Allen S, Baren J.  Neuroprotective effects of progesterone in traumatic brain injury: blunted in vivo neutrophil activation at the blood-brain barrier.  American Journal of Surgery 206(6):840-845, Dec. 2013 (Epub Oct. 7, 2013).
  41. Karamercan MA, Weiss SL, Villarroel JP, Guan Y, Werlin E, Figueredo R, Becker LB, Sims C.  Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation?  Shock 40(6):476-484, Dec. 2013.
  42. Ebbling L, Grabo DJ, Shashaty M, Dua R, Sonnad SS, Sims CA, Pascual JL, Schwab CW, Holena DN. Psoas: Lumbar vertebra index: Central sarcopenia independently predicts morbidity in elderly trauma patients. European Journal of Trauma & Emergency Surgery 40(1):57-65, Feb. 2014.
  43. Pascual JL, Blank NW, Holena DN, Robertson MP, Diop M, Allen SR, Martin ND, Kohl BA, Sims CA, Schwab CW, Reilly PM.  There's no place like home: Boarding surgical ICU patients in other ICUs and the effect of distances from the home unit.  Journal of Trauma & Acute Care Surgery 76(4):1096-1102, Apr. 2014.
  44. Kim L, Schuster J, Hoelna DN, Sims, CA, Levine J, Pascual JL.  Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on the brain imaging. J Emerg Trauma Shock 7(3): 141-148. Jul. 2014.
  45. Wang H, Guan Y, Becker L, Baur J, Sims CA.  Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock. Journal of Trauma & Acute Care Surgery 2014 (in press).
Reviews in Peer Reviewed Research Publications
  1. Stawicki  SP, Sims C, Sarani B, Grossman MD,  Gracias VH. Methylene blue: Who, when, and how? [Review] Mini Rev Med Chem 8:472-490, 2008.
  2. Cipolla J, Weger NS, Sharma R, Schrag SP, Sarani B, Truitt M, Lorenzo M, Sims CA, Kim PK, Torigian D, Temple-Lykens B, Sicoutris CP, Stawicki SP. Complications of vena cava filters: A comprehensive clinical review. [Review] OPUS 12 Scientist 2(2):11-24, 2008.
  3. Stawicki SP, Sims CA, Sharma R, Weger NS, Truitt M, Cipolla J, Schrag SP, Lorenzo M, El Chaar M, Torigian DA, Kim PK, Sarani B. Vena cava filters: A synopsis of complications and related topics. [Review] J Vasc Access 9(2):102-110, Apr.-June 2008.
  4. Brahmbhatt, S Tejal, Sims CA. Common Endocrinopathies in the Intensive Care Unit. [Review] Critical Connections, p.19, Dec- Jan 2013.
Research Publications, non-peer reviewed
  1. Sims CA, Wattanasirichaigoon S, Menconi MJ, Fink MP. Intravenous pyruvate and pyruvate ethyl ester ameliorate intestinal mucosal injury following ischemia/reperfusion. Surgical Forum, 1999;50:246-248.
Abstracts
  1. Lombardo G, Kim P, Reilly P, Sonnad S, Figueredo R, Sims C.  Effect of levothyroxine administration on the hemodynamic management of patients with trans-cranial gunshot wounds.”  Poster presentation, Society for Critical Care Medicine, Honolulu, HI, Feb. 2008.
  2. Jaffe R, Holmes L, Martin N, Sonnad S, Bergey M, Morgenthaler N, Struck J, Horan A, Guan Y, Deutschman C, Reilly P, Schwab CW, C Sims.  Copeptin levels predict the severity of shock in trauma patients.  Poster presentation, International Shock Congress, Cologne, Germany, June 2008.  Shock 29:S27-28, 2008.
  3. Sims C, Holmes L, Jaffe R. Vasopressin: The missing link of exsanguination protocols?” American Association for the Surgery of Trauma, Maui, HI, Sept. 2008.
  4. Grill E, Strong M, Sims C.  Altered Thyroid function in trauma patients in severe hemorrhagic shock.  Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2008.
  5. Strong ML, Grill EK, Sims CA.  Altered thyroid function in exsanguinating trauma patients.  Poster presentation, SCCM's 38th Critical Care Congress, Nashville, TN, Jan. 31-Feb. 4, 2009.  Crit Care Med 36:A65, 2008.
  6. Sims C, Jaffe R, Foreman J, Menger R, Sonnad S, Pascual J, Sarani B.   Adrenal insufficiency in hemorrhagic shock.  Poster presentation, SCCM's 38th Critical Care Congress, Nashville, TN, Jan. 31-Feb. 4, 2009.
  7. Sims C, Jaffe R, Foreman J, Menger R, Sonnad S, Pascual J, Sarani B. Adrenal insufficiency in hemorrhagic shock. Crit Care Med 2008;36:A65.
  8. JS Foreman, Menger R, Soonad S, Sims C. QS386 adrenal Insufficiency in trauma patients:Does massive transfusion cause low cortisol levels? J of Surg Res, 172 (2) p.300 (Feb 2009).
  9. Sims C, Holmes L, Jaffe R, Martin Nl.  Vasopressin deficiency in hemorrhagic shock: Are Initial Biomarkers Predictive?  Eastern Association for the Surgery of Trauma, Orlando, FL, Feb. 2009. (oral presentation)
  10. McCormick Z, Guan Y, Revere K, Becker L, Sims C.  Hemorrhagic shock does not induce early mitochondrial-mediated apoptosis in liver. J Surg Res, 151 (2) p.300, (Feb 2009).  4th Annual Academic Surgical Congress, Ft. Myers, FL, Feb. 3-6, 2009.
  11. Arthur K, Fox A, Sims C. "Panhypopituitarism Masquerading as Cardiac Failure Following Severe Traumatic Brain Injury: A Case Report."  14th Annual Challenges in Critical Care Conference. Hershey, PA. August 28, 2009.
  12. Sarani B, Powell E, Taddeo J, Carr B, Seamon M, Wobb J, Sims C, Pascual J, Patel A, Goldberg A, Schwab CW.  A contemporary comparison of surgical and interventional management arteriography of blunt renal injury.  American Association for the Surgery of Trauma, Pittsburgh, PA, Sept. 2009.
  13. Aized M, Aziz M, Abdurraheim M, Holena D, Sarani B, Pascual JL, Sims CA.  Relative adrenal insufficiency: The impact of hemorrhagic shock.  Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2009.
  14. Arthur K, Grill E, Sabra D, Rhodes K, Datner E, Pascual J, Sarani B, Kim P, Sims C. Screening for intimate partner violence in trauma patients.  Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2009.
  15. Aized M, Aziz M, Abdurraheim M, Sarani B, Pascual JL, Sims CA.  Relative adrenal insufficiency: The impact of hemorrhagic shock.  Poster presentation, SCCM 39th Critical Care Congress, Miami, FL, Jan. 9-12, 2010.
  16. Dechert TA, McMaster M, Schweickert WD, Sonnad S, Fitzpatrick MK, Sims CA, Pascual JL, Sarani B.  Medical emergency team (MET) response in the non-hospitalized patient.”  Poster presentation, SCCM 39th Critical Care Congress, Miami, FL, Jan. 9-12, 2010.
  17. Ding W, Sarani B, Peterson J, Abdurraheim, Aized M, Sims CA, Gracias VH, Schwab CW, Pascual JL.  Hypertonic saline in critically ill patients reduces neutrophil adhesion receptor expression and restores respiratory burst.  Poster presentation, SCCM 39th Critical Care Congress, Miami, FL, Jan. 9-12, 2010.
  18. Menger RP, Telford G, Bergey M, Foreman J, Saran B, Kim P, Reilly PM, Schwab CW, Sims C. Risk factors associated with chest tube complications in trauma patients. 5th Annual Academic Surgical Congress, San Antonio, TX, Feb. 3-5, 2010.
  19. Sabra D, Bergey M, Grill E, Sarani B, Pascual J, Datner E, Sims C.  Intimate partner violence and the trauma team: More than education is needed. 5th Annual Academic Surgical Congress, San Antonio, TX, Feb. 3-5, 2010.
  20. Manger RP, Telford G, Bergey M, Foreman  J, Kim P, Sarani B, Reilly PM, Schwab S, Sims C. Risk factors associated with chest tube management complications in trauma patients. J of Surg Res 158 (2) p.416 (Feb 2010)
  21. Pascual JL, Ding W, Sims C, Sarani B, Horan A, Schwab W.  Hypertonic saline in the ICU reduces inflammation and increases shedding of receptors responsible for microcirculatory inflammation.  8th World congress on Trauma, Shock, Inflammation and Sepsis, Munich, Germany, Mar. 13, 2010.
  22. Pascual J, Rosen P, Horan A, Sarani B, Sims C, Schwab C.  Hypertonic fluids in SICU shock patients reduces fluid and oxygen requirements. Poster presentation, 33rd Annual Conference on Shock, Portland, OR, June 12-15, 2010.
  23. Rosenbloom J, Guan Y, Sawey E, Sarani B, Pascual J, Sonnad S, Becker L, Sims C. Posterior pituitary exhaustion in shock and resuscitation.  Poster presentation, 33rd Annual Conference on Shock, Portland, OR, June 12-15, 2010.
  24. C Sims, J Rosenbloom, Guan Y, Sarani B, Pascual J, Schwab CW, Becker L. Resuscitation of hemorrhagic shock with vasopressin restores liver cytochrome oxidase activity.  Poster presentation, American Association for the Surgery of Trauma 69th Annual Meeting, Boston, MA, Sept. 2010.
  25. Pascual JL, McNicholas A, Bridges A, Sims C, Sarani B, Fernandez F, Schwab CW. The effects of instituting a hospital guideline to reverse the coagulopathy of Plavix (clopidogrel) in traumatic brain injury patients.  Poster presentation, American Association for the Surgery of Trauma 69th Annual Meeting, Boston, MA, Sept. 2010.        
  26. Pascual JL, Georgoff P, Horan A, Sims C, Sarani B, Stiefel MF, LeRoux PD, Schwab CW. Brain tissue hypoxia in traumatic brain injury: are most commonly used interventions successful at correcting brain tissue oxygen deficits?  American Association for the Surgery of Trauma 69th Annual Meeting, Boston, MA, Sept. 2010.
  27. Sims C, Guan Y, J Rosenbloom, Sarani B, Pascual J, Becker L.  Resuscitation of hemorrhagic shock with vasopressin restores complex I function in multiple organs. Mitochondrial Physiology Society-FEBS Workshop, Obergurgl, Austria, Sept. 2010.(oral presentation)
  28. Arminder SJ, Sims CA, Atluri P, Hari DM, Bavaria JE, Desai ND.  Successful outcome after left ventricle laceration, myocardial infarction and ventricular septal defect caused by penetrating trauma to the heart.  48th Annual Pennsylvania Association for Thoracic Surgery, Orlando, FL, Oct. 2010.
  29. Benns M, Carr B, Kallan M, Sims C. The incidence of organ dysfunction after traumatic injury: an analysis using the nationwide inpatient sample.  Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2010
  30. Morris D, Sundaram MT, Rohrbach J, Rogers M, Sonnad S, Sims C. The Surgical revolving door:  J of Sur Res 165 (2) p.333 (Feb 2011) Who gets readmitted to the hospital? Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2010.
  31. Sakran J, Finneman B, Maxwell C, Sonnad S, Sims C. Trauma leadership: Dose perception drive reality? Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2010.
  32. Tolstoy N, Holtz K, Guan Y, Sims C, Holena D. The association between self-assessed fear and pain levels, catecholamines, and lactate in hemodynamically stable trauma patients. Pennsylvania Committee on Trauma, Harrisburg, PA, Oct. 2010.
  33. Sims C, Arthur K, Grill E, Datner E, Pascual J, Sarani B, Kim P, Rhodes K. Screening for intimate partner violence in an urban trauma bay: Use of a self-disclosure survey. American Public Health Association 138th Annual Meeting, Denver, CO, Nov. 2010. (oral presentation)
  34. Morris DS, Rohrbach JI, Rogers MP, Sandaram MT, Sonnad SS, Pascual JL, Sarani B, Sims CA. The surgical revolving door: Who gets readmitted to the hospital? 6th Annual Academic Surgical Congress, Huntington Beach, CA., Feb. 2011.
  35. Sakran JV, Finneman B, Maxwell C, Sonnad SS, Sarani B, Pascual JL, Sims CA. Trauma leadership: Does perception drive reality? 6th Annual Academic Surgical Congress, Huntington Beach, CA, Feb. 2011.
  36. Holena D, Sims C, Kim P, Sarani B, Pascual J, Braslow B, Reilly P, Schwab C. Trauma bay predictors of mortality after massive transfusion protocol activation: a ten year experience, 12th European Congress of Trauma and Emergency Surgery, Milan, Italy, April 2011.
  37. McMonagle MP, Guan Y, Tolstoy N, Holena D, Kilty C, Keenan J, Sims C. Serum alpha glutathionine S-transferase: A novel biomarker of shock and resuscitation. 34th Annual Conference on Shock, June 2011.
  38.  Morris D, Schweickert W, Handzel R, Holena D, Sims C, Pascual J, Sarani B. It the attending physician needed at rapid response activations? Crit Care Med 2011; 39:121.
  39. Bruns B, Taddeo J, Bassett G, Pascual J, Holena D, Sonnad S, Reilly P, Schwab CW, Sims CA.  Seeking Closure: A pilot study of a novel dynamic fascial closure technique following damage control laparotomy. Paper presentation, AAST 70th Annual Meeting in Chicago, IL, (Sept 2011).
  40. Benns MV, Brendan GC, Kallan MJ, Reilly PM, Sims CA. Benchmarking the incidence of organ failure after injury at trauma and non-trauma centers in the U.S. Paper presentation, AAST 70th Annual Meeting in Chicago, IL (Sept 2011).
  41. Pascual JL, Fang P, Sarani B, Sims C, Schwab CW. The steadily increasing incidence and lethality of penetrating brain injury: A single trauma bay GCS point drop increases mortality. Paper presentation, AAST 70th
  42. Morris DS, Rohrbach J, Rogers M, Thanks Sundaram LM, Sonnad S, Pascual J, Sarani B, Reilly P, Sims C.  The surgical Revolving door: Risk factors for hospital readmission. J of Surg Res 170 (2) pp.297-301 (Oct 2011)
  43. Dutton R, McCunn M, Pascual J, Sims C, Vavilala M.  Anesthesiologists’ Management of unstable trauma patients differs from accepted trauma surgical guidelines. Crit Care Med 2012; 40:12. (poster presentation)
  44. Marks JA, Li S, Gong W, Sanati P, Eisenstadt R, Sims C, Sarani B, Pascual JL. In vivo inflammation of the blood brain barrier microcirculation after TBI: HTS is not superior to mannitol. Poster Presentation, 26th Annual Scientific Assembly in Chicago, IL. (Jan 2012)
  45. Fang P, Holena D, Weibe P, Kim P, Sims C, Sarani B, Schwab W, Pascual JL. J of Sug Res, 172 (2) p.348. (Feb 2012)
  46. Massey PR, Sakran JV, Sarani B, Sims CA, Pascual JL, Holena D. Hyperbaric oxygen therapy in patients with necrotizing soft tissue infections: No impact on mortality or amputation rate. J of Surg Res, 172 (2) p.348 (Feb 2012)
  47. Tolstoy N, Aized M, McMonagle M, Holena D, Pascual P, Sonnad S, Sims CA. Mineralocorticoid deficiency in hemorrhagic shock. J Surg Res 172 (2) p.346 (Feb 2012)
  48. Skokan AJ, Perales Villarroel JP, Rohrbach J, Pisa M, Holena DN, Sonnad SS, Sims CA.  End of life and acute care surgeon: the question of emergently palliate cancer patients is associated with startlingly high mortality. J of Sur Res 172 (2) p.347 (Feb 2012)
  49. Marks JA, Hurd JR, McNicholas A, Sims C, Sarani B, Schwab CW, Pascual JL. Delay in blood product transfusion in TBI patients on clopidogrel or warfarin worsens neurologic outcome. J of Surg Res, 172 (2) p.348. (Feb 2012)
  50. Becker L B, Guan Y, Selak M, Sims CA, Villarroel Perales PJ, Werlin E. The mitochondrial        membrane potential decreases in peripheral blood mononuclear cells along with the increase in lactate levels in hypovolemic shock in rats. Paper presentation to EAST 26th Annual Scientific Assembly, Scottsdale, AZ Jan. 2013.
  51. Becker L B, Guan Y, Selak M, Sims CA, Villarroel Perales PJ. Banked Platelets showed decrease mitochondrial respiratory capacities and progressively decrease response to activation.  J of Surg Res, 179 (2) pp.270-271 (Feb 2013) Paper presentation to ASC 8th Annual Academic Surgical Congress, New Orleans LA, Feb 2013.
  52. Jacovides C.L, Bruns B, Holena D, Sims CA, Reilly PM, Pascual JL. Penetrating injuries in urban female patients: worrisome trends outside our social radar?  J of Surg Res, 179 (2) p.274 (Feb 2013). Paper presentation at ASC 8th Annual Academic Surgical Congress, New Orleans LA, Feb 2013.
  53. Greer S.E, Speck R.M, Sundaram L.M, Isserman J, Nathanson P.G, Sonnad S, Sims CA. The community speaks:Analyzing attitudes about the Avert Shock trial and exception from informed consent (EFIC) in emergency research.  J of Surg Res 179 (2) p.337 (Feb 2013) Paper presentation at ASC 8th Annual Academic Surgical Congress, New Orleans LA, Feb 2013.
  54. Eisenstadt R, Sensenig R.L, Holena D, Sims C, Braslow B, Pascual J. Dislodged surgical feeding tubes: Should we abandon bedside contrast abdominal KUBs in favor of CT. J of Surg Res 179 (2) p.339. Paper presentation at ASC 8th Annual Academic Surgical Congress, New Orleans LA, Feb 2013.
  55. Drescher C.S, Sonnad S.S, Sims CA. Does liquor save lives? The impact of blood alcohol level on traumatic brain injury outcomes. J of Surg Res 179 (2) p.346. Paper presentation at ASC 8th Academic Surgical Congress, New Orleans LA, Feb 2013.
  56. Schwed AC, Sonnad SS, Holena DH, Pascual JL, Reilly P, Sims CA. Take a deep breath! Managing rib fractures in elderly trauma patients. Journal of Surgical Research 179(2):346, Feb. 2013.
  57. Karamercan MA, Villarroel JP, Guan Y, Weiss SL, Werlin EC, Figueredo R, Becker LB, Sims CA.  Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock 39(2 suppl): 16, 2013.  Podium Presentation, 36th Annual Conference on Shock, San Diego, CA, June 1-4, 2013 *Finalist for New Investigator Award.
  58. Sims CA, Y Guan, Karamercan MA, Selek M, Baur JA, Becker LB. Mitochondrial function during hemorrhagic shock and resuscitation: Where you come from counts. Shock 39(2 suppl):21, 2013.  Podium presentation, 36th Annual Conference on Shock, San Diego, CA, June 1-4, 2013. 
  59. Werlin EC, Guan Y, Agarwal B, Baur JA, Villarroel JP, Figueredo R, Karamercan MA, Becker LB, Sims CA.  Resuscitation with arginine vasopressin reduces oxidative damage in kidney mitochondria following hemorrhagic shock. Shock 39(2 suppl):42, 2013.  Poster and Quick Shot Oral Presentation, 36th Annual Conference on Shock, San Diego, CA, June 1-4, 2013.
  60. Gong W, Li S, Kumasaka K, Eisenstadt R, Browne K, Douglas S, Murcy MA, Sims CA, Allen SR, Pascual JL. Type of resuscitation fluid alters BBB inflammation a day after shock: An in-vivo cerebrovascular study. Shock 39(2 suppl):50, 2013. Poster Presentation, 36th Annual Conference on Shock, San Diego, CA, June 1-4, 2013.
  61. Eisenstadt RG, Sanati-Mehrizy P, Gong W, Murcy M, Kumasaka K, Sims CA, Allen SR, Becker LB, Pascual JL. Development of a rodent model of repeated immunomodulating resuscitation for sepsis allows delayed in vivo evaluation of microcirculation. Shock 39(2 suppl):67, 2013. Poster Presentation, 36th Annual Conference on Shock, San Diego, CA, June 1-4, 2013.
  62. Sims CA, Guan Y, Selak M, Baur JA, Becker L. Mitochondrial function during hemorrhagic shock and resuscitation: Where you come from matters.  Poster Presentation, 3rd Regional Translational Research in Mitochondria, Aging & Disease Symposium. Philadelphia, PA, Oct. 12, 2013.
  63. Nitzschke SL, Abella BS, Leary M, Schweickert WD, Sims CA, Pascual JL, Holena DN. Therapeutic hypothermia following cardiac arrest in surgical patients. Surgical Forum Oral Presentation, ACS Clinical Congress, Washington, DC, Oct. 10, 2013.
  64. Sims CA, Wang H, Guan Y, Becker LB, Baur JA.  Resveratrol preserves kidney mitochon-drial function and mitigates oxidative injury following hemorrhagic shock.  Poster Presentation. 2013 Joint IDOM-IFI Symposium, University of Pennsylvania, Philadelphia, PA, Nov. 8, 2013.
  65. Wang H, Guan Y, Ye L, Widlund AL, Becker LB, Baur JA, Sims CA.  Resveratrol rescues kidney mitochondrial function following hemorrhagic shock.  Quick Shot Presentation, 9th Annual Academic Surgical Congress, San Diego, CA, Feb. 2014.
  66. Braslow B, Holena D, Kim P, Sims C, Pascual JL, Allen S, Martin N, Petetti C, Schwab C, Reilly P.  Financial implications of the addition of an acute care surgery service: A ten year experience. 9th Annual Academic Surgical Congress, San Diego, CA, Feb. 2014.
  67. Sims CA, Wang H, Guan Y, Becker LB, Baur JA. Resveratrol preserves kidney mito-chondrial function and mitigates oxidative injury following hemorrhagic shock.  Poster Presentation, Mitochondrial Dynamics and Physiology, Keystone Symposia Conference, Santa Fe, NM, Feb. 21, 2014.
  68. Wang H, Guan Y, Widlund AL, Becker LB, Baur JA, Sims CA.  Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.  Podium Presentation, Western Trauma Association Annual Meeting, Steamboat Springs, CO, Mar. 7, 2014.
  69. Wang H, Guan Y, Becker LB, Baur JA, Sims CA. Resveratrol restores kidney mitochondrial function following shock. Annual Shock Society Meeting, Charlotte, NC, June 10, 2014.
Editorials, Reviews, Chapters
  1. Sims C, Berger D.  Abdominal vascular injuries.  Chap. 23 in Sheridan R (ed): The Trauma Handbook of the Massachusetts General Hospital.  Philadelphia: Lippincott Williams & Wilkins, 2004, 351-371.
  2. Sims CA, Rattner DW.  Technical surgical failures: Presentation, etiology and evaluation.  Chap. 8 in Ferguson MK, Fennerty MB (eds): Failed Antireflux Therapy: Evaluation and Management.  London: Springer, 2006, 91-102.
  3. Sims CA, Kim PK. Use clindamycin in necrotizing fasciitis to cover group a streptococcus. Chap.152 in Marcucci L, Martinez EA, Haut ER, Slonim AD, Suarez JI (eds): Avoiding Common ICU Errors. Philadelphia: Lippincott Williams & Wilkins, 2007, 362-363.
  4. Sims CA, Reilly PM. Penetrating neck trauma.  In Cameron JL (ed): Current Surgical Therapy, 9th Edition. St. Louis: Mosby, 2007, 1059-1062.
  5. Nagpal S, Halpern CH, Sims C, Gracias VH, Schuster JM, LeRoux PD, Levine JM. Decompressive laparotomy to treat intractable cerebral hypoxia. [Case Report] Journal of Trauma 67(5):E152-155, Nov. 2009.
  6. Plackett TP, Coviello LC, Belnap CM, Phillips KJ, Sims CA. Intussusception and colonic ischemia in portal hypertension: A case report. [Case Report] Hawi’i Medical Journal 69(2):39-41, Feb. 2010.
  7. Sims CA, Reilly PM. Care of the potential organ donor. Chap. 38 in Rabinovici R, Frankel H, Kirton O (eds): Trauma, Surgical Critical Care, and Surgical Emergencies.  London, UK: Informa, 2010, 339-346.
  8. Sims CA, Gracias V. Adrenal insufficiency.  Chap. 40 in Rabinovici R, Frankel H, Kirton O (eds): Trauma, Surgical Critical Care, and Surgical Emergencies.  London, UK: Informa, 2010, 358-361.
  9. Sims CA. Endocrine emergencies in the intensive care unit. In Deutschman CS, Nellgan PJ (eds): Evidenced-Based Practice of Critical Care. Philadelphia: WB Saunders/ Elsevier, 2010, 525-541. 
  10. Sims CA. Organ donation: Management of the organ donor. In Vincent JL, Hall J (eds): Encyclopedia of Intensive Care Medicine.  Berlin/Heidelberg: Springer, 2012, 1630-1634.
  11. Brahmbhatt ST, Sims CA. Common endocrinopathies in the Intensive Care Unit. [Review] Critical Connections, p.19, Dec- Jan 2013.
  12. Sanborn M, Sims CA. Endocrine evaluation. Chap. 21 in Le Roux, Levine, Kofke (eds): Monitoring in Neurocritical Care.  Philadelphia: WB Saunders, 2013, 200-209.
  13. Allen S, Sims C.  Evaluation of the trauma patient.  In Lanken P: The Intensive Care Unit Manual, 2nd Edition. Philadelphia: WB Saunders/Elsevier, 2014 (in press).
Alternative Media
  1. Polk T, Sims C. Life and Limb: Tourniquet saves man severely injured in vehicle crash.  Journal of Emergency Medical Services On-line Sept. 2012 (http://www.jems.com/article/patient-care/rollover-car-crash-almost-costs-driver-h).
Patents
  1. Ajami AM, Sims CA, Fink MP: Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion. U.S. Patent Number 10,116,707 – August 23, 2004.
 
Awards, Honors and Membership in Honorary Societies:
1995 AOA
 
1998 Edward D. Churchill Surgical Fellowship
 
1999 Massachusetts Committee on Trauma, American College of Surgeons, Resident Paper Award
 
2000 Harvard Center for Minimally Invasive Surgery, US Surgical Research Fellowship
 
2001 Raymond H. Alexander Resident Paper Competition:
Finalist, Eastern Association for the Surgery of Trauma
 
2006 American Association for the Surgery of Trauma Research Scholar
 
2007 McCabe Research Grant Recipient, University of Pennsylvania

Dr. Carrie Sims

 
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