Dr. Sunil Singhal is a General Thoracic Surgeon and practices surgery on all aspects of the chest.  His practice is focused on lung cancer and esophageal cancer, including complex resections and advanced disease.  He performs minimally invasive (VATS and robotic) pulmonary surgery.  In addition, he performs mediastinal surgery (diseases of the thymus gland), pleural disease, microinvasive hyperhidrosis surgery and pectus excavatum (Ravitch and Nuss repairs).

Dr. Singhal is the Director of the Thoracic Surgery Research Laboratory and his interest lie in intraoperative imaging to detect small quantities of disease and immunotherapy to treat patients with advanced lung and thymic cancer.  He is conducting several clinical trials to improve care for patients with advanced disease for cure.

• American Association for the Advancement of Science
• American Association for Cancer Research
• American College of Chest Physicians
• American College of Surgeons
• American Society of Clinical Oncology
• American Thoracic Society
• Association for Academic Surgery
• General Thoracic Surgery Biology Club
• International Society for Minimally Invasive Cardiothoracic Surgery
• Society for Surgery of the Alimentary Tract (candidate member)
• Society of Surgical Oncology
• Society of Thoracic Surgeons (candidate member)

• The Johns Hopkins Medical and Surgical Association
• Pennsylvania Society of Thoracic Surgery

• Society of Thoracic Surgery Workforce for Evidence-Based Surgery (2007-present)

1. Singhal S, Wiewrodt R, Friscia M, Matzie K, Friedberg J, Amin KA, Kucharczuk JC, Albelda SM, Kaiser LR. “Genomic profiling to explain positive PET-18FDG imaging in patients with malignant pleural mesothelioma”.  Journal of Surgical Research 107:284, 2002.
2. Cook J, Sterman DH, Singhal S, Smythe WR, Kaiser LR. “Suramin Inhibits The Growth Of Malignant Mesothelioma In Vitro, And In Vivo, In Murine Flank And Intraperitoneal Models.” Lung Cancer. 42(3):263-74, 2003.
3. Singhal S, Amin K, Kruklitis R, DeLong P, Friscia ME, Putt ME, Kaiser LR, Albelda SM. “Alterations in Cell Cycle Genes in Early Stage Lung Adenocarcinoma Identified by Expression Profiling.” Cancer Biology and Therapy. 2(3), 2003.
4. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf G, Albelda SM. “Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice.” American Journal of Respiratory and Cellular Molecular Biology. 28(6):682-696, 2003.
5. Singhal S, Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda SM. “Microarray Data Simulator to Evaluate Bioinformatic Tools for Selecting Differentially Expressed Genes in Normal versus Cancerous Tissues.” Cancer Biology and Therapy. 2(4): 383-394, 2003.
6. Singhal S, Weiwrodt R, Malden, L, Matzie K, Friedberg J, Amin KM, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. “Gene Expression Profiling of Malignant Mesothelioma.” Clinical Cancer Research. 9: 3080-3097, 2003.
7. Paulson EC, Singhal S, Kucharczuk JC, Sterman D, Kaiser LR, Marshall MB. “Bronchial sleeve resection for posttransplant stricture.” Annals of Thoracic Surgery. 76(6):2075-6, 2003.
8. Singhal S, Amin K, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Albelda SM, Kaiser LR. “Differentially Expressed Apoptotic Genes in Node Negative Lung Adenocarcinoma Predicted by Expression Profiling.” Cancer Biology and Therapy. 2:566-571, 2003.
9. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. “Comparison of Stages I-II Thymoma Treated by Complete Resection with or without Adjuvant Irradiation.” Annals of Thoracic Surgery. 76:1635-42, 2003.
10. Lee LS, Singhal S, Brinster CJ, Kaiser LR, Marshall MB, Kochman ML, Kucharczuk JC. “Current Management of Esophageal Leiomyoma.” Journal of American College of Surgeons. 198(1):136-46, 2004.
11. Brinster CJ, Singhal S, Lee LS, Marshall MB, Kaiser LR, Kucharczuk JC. “Evolving Options in the Management of Esophageal Perforation.”  Annals of Thoracic Surgery. 77: 1475-83, 2004.
12. Kruklitis R, Singhal S, DeLong P, Kapoor V, Sterman D, Kaiser LR, Albelda SM. “Neoadjuvant Immuno-Gene Therapy with Interferon-Beta Before Surgical Debulking Prevents Recurrence and Improves Survival in Advanced Malignant Mesothelioma.”  The Journal of Thoracic and Cardiovascular Surgery. 127(1): 123-130, 2004.
13. O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. “Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity.” Oncogene. 24:1244-51, 2005.
14. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. “Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer.” Clinical Cancer Research. 11: 3974-3986, 2005.
15. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. “Gene Induction During Differentiation of Human Pulmonary Type II Cells In Vitro.” American Journal of Respiratory Cell & Molecular Biology. 34: 727-737, 2006.
16. Nathan H, Singhal S, Cameron JL. “Benign pneumatosis intestinalis in the setting of celiac disease.” Journal of Gastrointestinal Surgery. 10(6):890-4, 2006.
17. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. “A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma.” Clinical Cancer Research. 13(10):2905-15, 2007.
18. Singhal S, Miller DL, Ramalingam S, Sun SY. “Gene Expression Profiling of Non-Small Cell Lung Cancer.” Lung Cancer. 60: 313-324, 2008.
19. Fabre D, Fadel E, Singhal S, Monpreville VD, Mussot D, Mercier O,  Chataigner O, Dartevelle PG. “Complete Resection of Pulmonary Inflammatory Pseudotumors Has Excellent Long Term Prognosis.” The Journal of Thoracic and Cardiovascular Surgery. Feb; 137(2):435-40, 2009.
20. Fabre, D, Singhal S, De Montpreville V, Decante B, Mussot S, Chataigner O, Mercier O, Kolb F, Dartevelle PG and Fadel E.  “Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection.” The Journal of Thoracic and Cardiovascular Surgery 138(1): 32-9, 2009.
21. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LS, Singhal S, Snyder LA, Albelda SM. “CCL2 Blockade Augments Cancer Immunotherapy.” Cancer Research.  Jan; 70(1):109-118, 2010.
22. Fridlender ZG, Sun J, Singhal S, Kapoor V, Cheng G, Albelda SM. “Chemotherapy delivered after  viral immunogene therapy augments anti-tumor efficacy via multiple immune-mediated mechanisms.” Molecular Therapy, 18(11): 1947-59, 2010.
23. Singhal S. Ferraris VA, Bridges CR, Clough ER, Mitchell JD, Fernando HC, Shrager JB. “Postoperative Management of Pulmonary Alveolar Air Leaks.” Annals of Thoracic Surgery. 89(4): 1327-35, 2010.
24. Singhal S, Shrager JB. “Intraoperative prophylaxis and management of pulmonary parenchymal air leaks.” Journal of Thoracic and Cardiovascular Surgery. 140(6): 1220-5, 2010.
25. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S.  “A Handheld Spectroscopic Device for In Vivo and Intraoperative Tumor Detection: Contrast Enhancement, Detection Sensitivity, and Tissue Penetration.” Analytical Chemistry, Oct 6 2010.
26. Singhal S, Nie S, Wang MD. “Nanotechnology applications in surgical oncology.” Annu Rev Med; 61:359-373, 2010.
27. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LC, Singhal S, Snyder LA and Albelda SM. “Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells." Am J Respir Cell Mol Biol 44(2): 230-7, 2011.
28. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, Cohen NA, Mirza N. “Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis.” Otolaryngol Head Neck Surg. 144(6):927-33, 2011.
29. Brunelli, A. Beretta E, Cassivi S., Cerfolio R., Detterbeck F., Kiefer T.,  Miserocchi G., Shrager J, Singhal S, Raemdonck DV, Varela G. “Consensus definitions to promote an evidence-based approach to management of the pleural space.  A collaborative proposal by the ESTS, AATS, STS, and GTSC.” European Journal of Cardiothoracic Surgery. 40: 291-297, 2011.
30. Berman AT, Litzky L, Livolsi V, Singhal S, Kucharczuk JC, Cooper JD, Friedberg JR, Evans TL,  Stevenson J, Metz JM, Hahn SM, Rengan R. “Adjuvant Radiotherapy for Completely Resected Stage II Thymoma.” Cancer. 117(15): 3502-8, Feb 1 2011.
31. Aliperti LA, Predina JD, Vachani A, Singhal S. “Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery.” Annals of Surgical Oncology. 18(3): 603-607, 2011.
32. Su L, Liu G, Hao X, Liu X, Zhong N, Zhong D, Singhal S. “Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells.” European Journal of Cancer. 47(16): 2471-8, 2011.
33. Liu G, Su L, Hao X, Zhong N, Singhal S, Liu X. “Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Programmed Cell Death.” Journal of Cellular and Molecular Medicine. July 31 2011.
34. Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V, Nakagawa H, Rustgi AK, Aguilar L, Aguilar-Cordova E, Albelda SM, Singhal S. “Neoadjuvant in situ Gene-Mediated Cytotoxic Immunotherapy Improves Postoperative Outcomes in Novel Syngeneic Esophageal Carcinoma Models.” Cancer Gene Therapy. 18(12): 871-883. 2011.
35. Levine S, Budak MT, Dierov J, Singhal S. “Inactivity-induced diaphragm dysfunction and mitochondrial-targeted antioxidants.” Critical Care Medicine. 39(7):1844-5, 2011.
36. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT.   “Increased proteolysis and atrophic AKT-FOXO Signaling in Human Diaphragm Disuse.”American Journal of Respiratory and Critical Care Medicine. 183(4): 483-90, 2011.
37. Tucker ZCG, Laguna BA, Moon E, Singhal S. “Adjuvant immunotherapy for non-small cell lung cancer.” Cancer Treatment Reviews. 38(6):650-61, 2012.
38. Laguna BA, Tucker ZCG, DeLisser H, Singhal S. "Letting the Air in Can Set the Stage for Tumor Recurrences.” Current Cancer Therapy Reviews. 8(4):293-303, Nov 2012.
39. Fabre D, El Batti S, Singhal S, Mercier O, Mussot O, Fadel E, Kolb F, Dartevelle PG. “A paradigm shift for sternal reconstruction using a novel titanium rib bridge system following oncological resections.” European Journal of Cardiothoracic Surgery. 42(6):965-70. Dec 2012.
40. Fridlender ZG,  Sun  J, Mishalian I, Singhal S, Cheng G,  Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM.   “Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils.”  PLoS ONE. 7(2):e31524. 2012.
41. Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk J, Singhal S, Vachani A. “MicroRNA expression profiles of whole blood in lung adenocarcinoma.” PLOS One. 7(9): e46045, Sept 2012.
42. Majumdar D, Singhal S. “Medicinal Chemistry and Nanomedicine for Reproductive Cancer Therapeutics.” Front Biosci (Elite Ed). 4: 2029-44, 2012.
43. Jia G, Su L, Singhal S, Liu X. “Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging.” Molecular and Cellular Biochemistry. 364(1-2): 345-350, 2012.
44. O'Shannessy D J, Yu G, Smale R, Fu YS, Singhal S, Thiel RP, Somers EB, and Vachani A. “Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance.” Oncotarget. 3(4):414-25, 2012.
45. Predina JD, Judy B, Kapoor V, Blouin A, Aliperti LA, Levine D, Fridlender ZG, Singhal S. “Characterization of Surgical Models of Postoperative Tumor Recurrence For Preclinical Adjuvant Therapy Assessment.” Am J Translational Research. 4(2): 206-218, 2012.
46. Madajewski B, Judy B, Mouchli A, Kapoor V, Holt D, Wang MD, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease.” Clinical Cancer Research. 18(20): 5741-51. Oct 15, 2012.
47. Predina JD, Fridlender ZG, Judy B, Kapoor V, Aliperti L, Blouin A, Albelda SM, Singhal S. “The Importance of Well-Characterized Murine Surgical Models of Tumor Recurrence for Preclinical Studies of Adjuvant Therapy.” Cancer Biology and Therapy. 13(9):1-11, 2012.
48. Predina JD, Kapoor V, Judy BF, Cheng G, Fridlender ZG, Albelda SM, Singhal S. “Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness.” Journal of Hematology and Oncology. 5(1): 34, 2012.
49. Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, Singhal S. “Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery.” Neoplasia. 14(4): 352-9, 2012.
50. Fridlender Z, Jasaar A, Mishalian I, Wang LC, Kapoor V, Cheng G, Sun J, Singhal S, Levy L, and Albelda SM. “Using Macrophage Activation to Augment Immunotherapy of Established Tumors.” British Journal of Cancer. 108(6):1288-97, April 2, 2013.
51. Li T, Su L, Zhong N, Singhal S, Liu X “Salinomycin Induces Cell Death with autophagy through activation of Endoplasmic Reticulum Stress in Human Lung Cancer cells.” Autophagy. 9(7). April 18, 2013.
52. Fedor D, Johnson WR, Singhal S. “Local recurrence following lung cancer surgery: Incidence, risk factors, and outcomes.” Surgical Oncology. (22) 156-161, 2013.
53. Ghosh A, Philiponis G, Lee JY, Leahy KP, Singhal S, Cohen NA, Mirza N. "Pulse steroid therapy inhibits murine subglottic granulation." Otolaryngol Head Neck Surg. 148(2): 284-90. Feb 2013.
54. Johnson WR, Fedor D, Singhal, S. “A novel approach to eliminate cardiac perforation in the Nuss procedure.” Ann Thorac Surg 95, 1109-1111, 2013.
55. Predina JD, Eruslanov E, Judy B, Kapoor V, Cheng GJ, Wang S, Sun J, Fridlender G, Albelda SM, Singhal S. “Changes in the Local Tumor Microenvironment in Recurrent Cancers May Explain the Failure of Vaccines after Surgery.” Proceedings of the National Academy of Sciences USA. 110(5): E415-24. Jan 29, 2013.
56. Levine S, Bashir M, Clanton T, Powers S, Singhal S.  “COPD Elicits Remodeling of the Diaphragm and Vastus Lateralis Muscles in Humans.”  Journal of Applied Physiology. 114(9): 1235-1245.  May 1, 2013.
57. Quatromoni JG, Suzuki E, Okusanya O, Judy BF, Bhojnagarwala P, Venegas O, Eruslanov E, Predina JD, Albelda SM, Singhal S. “The timing of TGF-β inhibition affects the generation of antigen-specific CD8+ T Cells.” BMC Immunology. 14:30, 2013.
58. Waldron TJ, Quatromoni JG, Karakasheva TA, Singhal S, and Rustgi, AK. “Myeloid derived suppressor cells: Targets for therapy.” Oncoimmunology, 2: e2411-7, 2013.
59. Liu Y, Wang L, Predina J, Han R, Beier UH, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. “Inhibition of p300 Impairs Foxp3+ T-regulatory Cell Function and Promotes Anti-Tumor Immunity.” Nature Medicine. 19(9):1173-7. Sept 2013.
60. Okusanya OT, Madajewski B, Segal E, Judy BF, Venegas OG, Judy RP, Quatromoni JG, Wang MD, Nie S, Singhal S. “Small Portable Interchangeable Imager of Fluorescence for Fluorescence Guided Surgery and Research.” Technology in Cancer Research and Treatment. Dec 17, 2013.
61. Haft S, Lee JY, Ghosh A, Philiponis G, Malaisrie N, Leahy KP, Singhal S, Cohen NA, Mirza N. “Inflammatory protein expression in human subglottic stenosis tissue mirrors that in a murine model.” Ann Otol Rhinol Laryngol. 123(1):65-70. January 2014.
62. Quatromoni JG, Predina JD, Bhojnagarwala P, Judy RP, Jiang J, De Jesus EM, Kapoor V, Cheng G,  Okusanya OT, Eruslanov E, Singhal S. “Adenoviral Based Immunotherapy Provides Local Disease Control in an Orthotopic Murine Model of Esophageal Cancer.” Journal of Immunotherapy. 37(5): 283-292, Jun 2014.
63. Johnson WR, Fedor D, Singhal S. “Systematic review of surgical treatment techniques for adult and pediatric patients with pectus excavatum.” Journal of Cardiothoracic Surgery. 9 (1): 25. 2014.
64. Holt D, Okusanya OT, Judy R, Venegas O, Jiang J, DeJesus E, Eruslanov E, Quatromoni J, Bhojnagarwala P, Deshpande C, Albelda S, Nie S, Singhal S. “Intraoperative near-infrared imaging can distinguish cancer from normal tissue but not inflammation.” PlosOne. 9(7): e103342. July 2014.
65. Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, Singhal S. “Usp9x- and Noxa-mediated Mcl-1 down-regulation contributes to pemetrexed-induced apoptosis in human non-small cell lung cancer cells.” Cell Death and Disease. (5):e1316. July 3, 2014.
66. Mishalian I, Eruslanov E, Bayuch R, Levy L, Zolotorov L, Singhal S, Albelda SM, Fridlender ZG. “Neutrophils recruit T-regulatory cells into the tumor via secretion of CCL17 – a new mechanism of tumor immune surveillance.” International Journal of Cancer. 135(5): 1178-1186, 2014.
67. Akimova T, Xiao H, Liu Y, Bhatti TR, Jiao J, Eruslanov E, Singhal S, Wang L, Han R, Zacharia K, Hancock WW, Beier UH. “Targeting Sirtuin-1 Alleviates Experimental Autoimmune Colitis by Induction of Foxp3+ T-Regulatory Cells.” Mucosal Immunity. 7(5):1209-20. Sept 7, 2014.
68. Okusanya O, Holt D, Heitjan D, Deshpande C, Venegas O, Jiang J, Judy R, DeJesus E, Madajewski B, Albelda SM, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging Can Identify Pulmonary Nodules.” Annals of Thoracic Surgery. 98(4):1223-30. Oct 2014.
69. Hooijman PE, Paul MA, Stienen GJ, Beishuizen A, Van Hees HW, Singhal S, Bashir M, Budak MT, Morgen J, Barsotti RJ, Levine S, Ottenheijm CA. “Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation.” Am J Physiol Lung Cell Mol Physiol. 307(6):L460-70. Sept 15, 2014.
70. Wormser C, Singhal S, Holt DE, Runge JJ. “Thoracoscopic-assisted pulmonary surgery for partial and complete lung lobectomy in dogs and cats: 11 cases (2008-2013).” J Am Vet Med Assoc. 245(9):1036-41. November 1, 2014.
71. Okusanya OT, Deshpande C, Barbosa EM, Aggarwal C, Simone CB, Jiang J, Judy R, DeJesus E, Albelda S, Nie S, Low P, Singhal S. “Molecular Imaging to Identify Tumor Recurrence Following Chemoradiation in a Hostile Surgical Environment.” Molecular Imaging.  13(0): 1-6; November 1, 2014.
72. Eruslanov E, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S. “Inflammatory Tumor-associated Neutrophils in Early Stage Human Lung Cancer.” Journal of Clinical Investigation. 124(12):5466-80. December 1, 2014.
73. Quatromoni JG and Singhal S (co-first authors), Bhojnagarwala P, Hancock W, Albelda SM, Eruslanov E. “An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells.” Journal of Leukocyte Biology. 97(1): 201-9. January 2015.
74. Shen J, Putt KS, Visscher DW, Murphy L, Cohen C, Singhal S, Sandusky G, Yang F, Dimitrov DS, Low PS. “Assessment of Folate Receptor-β Expression in Human Neoplastic Tissues.” Oncotarget.  6(16): 14700-9. March 30, 2015.
75. Okusanya O, DeJesus E, Jiang J, Judy R, Venegas O, Deshpande C, Heitjan DF, Nie S, Low P, Singhal S. “Intraoperative Targeted Molecular Imaging Can Identify Lung Adenocarcinomas during Pulmonary Resection.” The Journal of Thoracic and Cardiovascular Surgery. 150(1): 28-35. July 2015.
76. Holt D, Parthasarathy AB, Okusanya O, Keating J, Venegas O, Yodh AG, Deshpande C, Karakousis G, Madajewski B, Durham A, Nie S, Singhal S. “Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds.” Journal of Biomedical Optics. 20(7): 76002-16. July 2015.
77. Jiang JX, Keating JJ, De Jesus EM, Judy RP, Madajewski B, Venegas O, Okusanya OT, Singhal S. “Optimization of the Enhanced Permeability and Retention Effect for Near-Infrared Imaging of Solid Tumors with Indocyanine Green.” American Journal of Nuclear Medicine and Molecular Imaging. 5(4): 390-400, 2015.
78. Kennedy GT, Okusanya OT, Keating JJ, Heitjan DF, Deshpande C, Litzky LA, Albelda SM, Drebin JA, Nie S, Low PS, Singhal S. “The optical biopsy: a novel method for rapid intraoperative diagnosis of primary pulmonary adenocarcinomas.” Annals of Surgery. 262(4): 602-609. October 2015. PMID: 26366539. 
79. Keating J, Kennedy G, Singhal S. “Identification of a subcentimeter pulmonary adenocarcinoma using intraoperative near-infrared imaging during video-assisted thoracoscopic surgery.” The Journal of Thoracic and Cardiovascular Surgery. 149(3): e51. April 2, 2015. PMID: 25827389.
80. Predina JD, Keating J, Patel N, Nims S, Singhal S. "Clinical implications of positive margins following non-small cell lung cancer surgery." J Surg Oncol. 2015. PMID: 26719121.
81. Keating JJ, Nims S, Venegas O, Jiang J, Holt D, Kucharczuk JC, Deshpande C, Singhal S. "Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy." Oncotarget. 7(3); 3059-3067. December 23, 2015. PMID: 26689990.
82. Judy RP, Keating JJ, DeJesus EM, Jiang JX, Okusanya OT, Nie S, Holt DE, Arlauckas SP, Low PS, Delikatny EJ,  Singhal S. “Quantification of tumor fluorescence during intraoperative cancer optical imaging.” Scientific Reports. 5:16208. November 13, 2015. PMID: 26563091.
83. Guzzo T, Jiang J, Keating JJ, DeJesus EM, Judy RP, Nie S, Low P, Lal P, Singhal S. “Intraoperative Molecular Diagnostic Imaging Can Identify Renal Cell Carcinoma.” November 7, 2015.  Journal of Urology. PMID: 26541080.
84. De Jesus EM, Keating JJ. Kularatne SA, Jiang JX, Judy R, Predina J, Nie S, Low P, Singhal S. “Comparison Of Folate Receptor Targeted Optical Contrast Agents For Intraoperative Molecular Imaging.” International Journal of Molecular Imaging. 469047. October 23, 2015. PMID: 26491562.
85. Keating JJ, Okusanya OT, DeJesus E, Judy RP, Jiang J, Deshpande C, Nie S, Low P, Singhal S. “Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Positive Surgical Margins.” Molecular Imaging and Biology. July 31, 2015. PMID: 26228697.

1. Singhal S, Kaiser LR. “Cancer Chemotherapy Using Suicide Genes.” Surgical Oncology Clinics of North America. 7(3):505-536, 1998.
2. Singhal S, Machtay M, Kaiser LR. “Malignant Mesothelioma.” In: Integrated Cancer Management. ed. Michael Torosian. New York: Marcel Dekker, 1999.
3. Singhal S, Kaiser LR.  “Benign and Malignant Mesothelioma.” In: Surgical Oncology: Contemporary Principles and Practice. ed. Kirby I. Bland, John M. Daly, and Constantine Karakousis.  New York: McGraw-Hill, 2001.
4. Singhal S, Johnson C, Udelsman R. “Primary Hyperparathyroidism: What Every Orthopedic Surgeon Should Know.” Orthopedics. 24(10): 1003-1008, 2001.
5. Singhal S, Kaiser LR. “Malignant Mesothelioma: Options for Management.” Surgical Clinics of North America. 82(4):797-831, 2002.
6. Singhal S, Shrager JB, Kaiser LR. “Biological Treatments for Lung Cancer.” In: Clinique des Soins Intensifs Oncologiques et de Cancerologie Pulmonaire. Ed. Jean-Paul Sculier and Williard A. Fry. Bruxelles, France: Reseau iris.
7. Greenberg J, Singhal S, Kaiser LR. “Giant Bullous Disease:  Evaluation, Selection, Techniques, and Outcomes.” Chest Surgery Clinics of North America. 13(4): 631-650. 2003.
8. Singhal S, Yang S. “Lung Volume Reduction Surgery: Median Sternotomy Approach.” In: Current Therapy in Thoracic and Cardiovascular Surgery. Ed. Stephen Yang and Duke Cameron. 2004.
9. Singhal S, Yang S. “Techniques and Results in Lung Transplantation.” In: Advanced Therapy in Thoracic Surgery, 2nd edition. ed. KL Franco and JB Putnam. BC Decker, 2005.
10. Dunham B, Le Visage CL, Singhal S, Flint P, Leong K. “Tracheal tissue engineering.”  In: Biomedical Engineering Fundamentals (The Biomedical Engineering Handbook), 3rd edition. ed. Bronzino. Boca Raton, FL: CRC Press, 2006.
11. Singhal S, Kaiser LR. “Video-assisted thoracic surgery.” In: Current Surgical Therapy. 9th edition. Ed. JL Cameron. Elsevier Science, 2007.
12. Singhal S, Kaiser LR. “Surgery for Myasthenia Gravis.” In: Pearson’s Thoracic Surgery, 3rd edition. Ed. A Patterson. Elsevier Science, 2008.
13. Singhal S, Shrager J, Kaiser LR. “Neoadjuvant Therapy for Non-Small Cell Lung Cancer.” In: General Thoracic Surgery, 7th edition. ed. Thomas W. Shields, Joseph LoCicero III, Carolyn E. Reed, Richard H. Feins. Chicago: Williams and Wilkins, 2009.
14. Merritt RE, Singhal S, Shrager JB. “Evidence-based Suggestions for Management of Air Leaks.” Chest Surgical Clinics of North America. 20(3):435-448, 2010.
15. Moon E, Singhal S, Haas A, Sterman DH, Albelda SM. “Gene Therapy for Malignant Mesothelioma.”  In: Roth J, ed. Gene-Based Therapies for Cancer. 1st ed. New York, NY: Springer; 2010:95-112.
16. Predina J, Kunkala M, Aliperti L, Singhal AK, Singhal S. “Sleeve Lobectomy.”  Annals of Thoracic and Cardiovascular Surgery.  16(5): 310-8, 2010.
17. Singhal S. “Thoracic Surgery.” In: General Surgery Review. ed. Marty A. Makary. 1st, 2nd, 3rd edition. Lippincott Williams & Wilkins. Philadelphia, 2013 (3rd edition).
18. Predina JD, Singhal S.  Diaphragmatic Disorders. Chap. 22 in Johns Hopkins Cardiothoracic Surgery, 2nd Edition. Yuh, Yang, Doty, Vricella (eds). New York: McGraw Hill, 2014.

1. Reilly P, Singhal S. “Esophageal Injury: Trauma.”  American College of Surgeons. Review for General Surgery Residents for American Board of Surgery test preparation. March 2009.
2. Baumgartner F, Singhal S. “Sympathectomy for Primary Hyperhidrosis.”  UpToDate.  Online Clinical Reference Library. Version 17.3. 2010. http://www.uptodateonline.com/.
3. Singhal S. “Esophageal Injury.” Online General Surgery Curriculum. Surgical Council on Resident Education. Sponsored through American Board of Surgery. 2013. http://www.surgicalcore.org.

1. Singhal S, Ratner L. “Unilateral Renal Agenesis with Pelvic Renal Ectopy.” Journal of the American College of Surgeons. 193(3): 330, 2001.
2. Singhal S, Johnson C, Udelsman R. “Primary Hyperparathyroidism: What Every Orthopedic Surgeon Should Know.” Orthopedics. Invited CME Quiz, 24(10): 1009-1011, 2001.
3. Singhal S, Wiewrodt R, Matzie K, Kucharczuk J, Friedberg J, Albelda SM, Kaiser LR. "Gene Expression Mapping to Diagnose Malignant Mesothelioma." Journal of American College of Surgeons. (Surgical Forum) 195(3S): 26-27, 2002.
4. Singhal S, Kruklitis R, Marshall B, Kucharczuk J, Albelda SM, Kaiser LR. "Viral Gene Transfer of Interleukin-12 prolongs survival and prevents recurrence in early and advanced non-small cell lung cancer." Journal of American College of Surgeons. (Surgical Forum) 197(3S): 28-29, 2003.
5. Singhal S, Vachani A, Kupferman M, Powell C, Gaffney P, Muschel R, Albelda SM, Kaiser LR. "Gene Expression Profiling to Distinguish Head and Neck Squamous Cell Carcinoma Metastases from Primary Lung Squamous Cell Carcinoma." Journal of American College of Surgeons. (Surgical Forum) 199(3S): 66, 2004.
6. Singhal S, Cooper JM, Cheung AT, Acker MA. “Rib perforation from a right ventricular pacemaker lead.”  Circulation. 115:391-392, 2007.
7. Kim SS, Fridlender ZG, Jassar AS, Blouin A, Kapoor V, Albelda SM, Singhal S. “The role of neoadjuvant transforming growth factor beta inhibition to prevent local recurrences and distant metastasis in advanced thoracic malignancies.” Journal of American College of Surgeons. (Surgical Forum), 2009.
8. White B, Raza SH, Kaddi C, Mancini M, Mohs A, Nie S, Wang MD, Singhal S. “The development of a novel endoscope to visualize residual tumor cells following cancer surgery.” Journal of American College of Surgeons. 209(3):S32-33, 2009.
9. Predina J. Aliperti L. Kapoor V. Ridge N. Albelda SM. Singhal S. “Modulation of cancer immunobiology to prevent recurrences following surgery for non-small cell lung cancer.” Journal of American College of Surgeons. 211(3):S36-37, 2010.
10. Predina J, Kotloff, Miller, Singhal S. “Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-Dubé syndrome.” European Journal of Cardiothoracic Surgery. 39: 404-406, 2011.
11. Judy B. Predina J. Mittal J. Deshpande C. Singhal S. “Metastatic primary pulmonary angiosarcoma.” Surgical Science. 2:130-132, 2011.
12. Ghosh A, Philiponis G, Lee J, Leahy KP, Singhal S, Einhorn E, Howlett P, Cohen NA, Mirza N. “Pulse Steroid Therapy Inhibits Murine Subglottic Granulation.”  Otolaryngology-Head and Neck Surgery.  Richard Rosenfeld (eds.). Sage Production, 145(2): 82, August 2011
13. Predina JD, Aliperti LA, Kapoor V, Nakagawa H, Rustgi AK, Cooper JD, Aguilar-Cordova E, Singhal S. “Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Oesophageal Carcinoma.” Interactive Cardiovascular and Thoracic Surgery. 2011 Sept; 11(S3):18.
14. Predina JD, Anolik RB, Judy B, Akers S, Freiman D, Ahmad D, Singhal S. “Intramural Esophageal Dissection in a Young Man with Eosinophilic Esophagitis.” Ann Thoracic and Cardiovascular Surgery. 18(1):31-5, Sept 29, 2012.
15. Georgoff P. Singhal S. “Multi-vessel intralobar pulmonary sequestration.” The Annals of Thoracic Surgery.  93(4):1318, Apr 2012.
16. Judy B, Singhal S. “How can cytoreduction surgery improve the prospects for cancer patients receiving immunotherapy?”  Immunotherapy. 4(11):1077-80, Nov 2012.
17. Lee JY, Cohen N, Singhal S, Leahy K, Ghosh A, Philiponis G, Mirza N. “Murine model of a drug eluting stent on subglottic stenosis.” Otolaryngology- Head and Neck Surgery. Richard M Rosenfeld (eds.). Sage Production, 147(2): 75, August  2012.
18. Lee JY, Singhal S, Leahy K, Cohen N, Philiponis G, Ghosh A, Mirza N. “Cyclo-oxygenase inhibition of LTC stenosis in the mouse model” Otolaryngology- Head and Neck Surgery. Richard M Rosenfeld (eds.). Sage Production, 147(2): 190, August  2012.
19. Gaffey AC, Litzky LA, Singhal S. “Primary mediastinal melanoma presenting as superior vena cava syndrome: A case study.” Arch Clin Exp Surg. 09 Aug, 2014.
20. Shah P, Han A, Patel R, Howlett P, Akers S, Margolis M, Singhal S. “Bronchoscopic Extraction Of a Chicken Bone Five Years Following Aspiration.” Ear Nose Throat Journal 94(1): 27-29, Jan 2015.
21. Keating J, Ryan J, Jiang J, DeJesus E, Crisman E, Singhal S. Intraoperative Molecular Imaging for Detecting Subcentimeter Pulmonary Tumors. Scientific Forum Abstract.  Surgical Oncology. Vol 221, No. 4S1, p 140. October 2015.