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Michael Ibrahim, MA(Cantab), MD, PhD
Cardiac Surgery Direct Resident

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Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)


Michael Ibrahim MD PhD is a PGY-3 Resident in the Integrated Cardiac Surgery Program at the University of Pennsylvania. He was educated at Gonville and Caius College, Cambridge and Imperial College London, graduating at the fore of his class. He has held honorary research fellowships at The Royal Brompton & Harefield Hospital, Great Ormond Street Hospital and The Heart Hospital.

Dr. Ibrahim completed his PhD under the mentorship of Sir Magdi Yacoub FRS OM. His research focuses on short and long term advanced therapies for heart failure. In particular, Dr. Ibrahim’s research aims to identify novel therapeutic mechanisms by which mechanical unloading induces reversal of heart failure, alone or in conjunction with novel, disruptive therapies. He also has a research interest in aortic root surgery, including The Ross Operation. He aspires to a career in academic cardiac surgery.

2015 - present Assistant Instructor in Surgery
2008 - 2014 MBBS/PhD - Imperial College School of Medicine
2005 - 2008 BA - University of Cambridge
Postgraduate Training and Fellowship Appointments
2015 - present Integrated Resident in Thoracic Surgery
University of Pennsylvania
2014 - 2015 Academic Foundation Doctor in Surgery (FY1)
St Thomas’ Hospital, UK
2012 - 2015 Honorary Research Fellow in Adult Congenital Heart Surgery
The Heart Hospital, UK
2010 - 2015 Honorary Research Fellow in Congenital Cardiac Surgery
Great Ormond Street Hospital
Special Certifications
2014 Associateship of Imperial College London School of Medicine
2012 MA - University of Cambridge
2014 - present British Medical Association (Member)
2009 - present American Heart Association (Member)
  Associate Member, Faculty of 1000 Experts in Biology

2009 - 2012 PhD - Terracciano/Gorelik/Yacoub Lab, Imperial College London
2008 BA - Physiology, Parker Lab,  University of Cambridge
2007 Medical student research assistant, Ibrahim Lab, University of Cambridge
Colorectal cancer progression
  1. Ibrahim, M., Al Masri, A., Navaratnarajah, M., Siedlecka, U., Soppa, G. K., Moshkov, A., Al-Saud, S. A., Gorelik, J., Yacoub, M. H., Terracciano, C. M.: Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface. FASEB J 24:3321-9, 2010
  2. El-Hamamsy, I., Ibrahim, M., Yacoub, M. H.: 30-year outcome of anatomic correction of anomalous origin of the left coronary artery from the pulmonary artery. J Am Coll Cardiol 57:1493, 2011
  3. Ibrahim, M., Terracciano, C. M., Yacoub, M. H.: Bridge to recovery: What remains to be discovered? Cardiol Clin 29:531-47, 2011
  4. Ibrahim, M., Gorelik, J., Yacoub, M. H., Terracciano, C. M.: The structure and function of cardiac t-tubules in health and disease. Proc Biol Sci 278:2714-23, 2011
  5. Mukherjee, D., Rao, C., Ibrahim, M., Ahmed, K., Ashrafian, H., Protopapas, A., Darzi, A., Athanasiou, T.: Meta-analysis of organ damage after conversion from off-pump coronary artery bypass procedures. Ann Thorac Surg 92:755-61, 2011
  6. El-Hamamsy, I., Ibrahim, M., Stevens, L. M., Witzke, H., Clark, L., Yacoub, M. H.: Early and long-term results of reoperative total aortic root replacement with reimplantation of the coronary arteries. J Thorac Cardiovasc Surg 142:1473-7, 2011
  7. Rao, C., Patel, V., Ibrahim, M., Ahmed, K., Wong, K. A., Darzi, A., von Segesser, L. K., Athanasiou, T.: Leadership in cardiac surgery. Eur J Cardiothorac Surg 39:905-11, 2011
  8. Ibrahim, M., El-Hamamsy, I., Barbir, M., Yacoub, M. H.: Translational lessons from a case of combined heart and liver transplantation for familial hypercholesterolemia 20 years post-operatively. J Cardiovasc Transl Res 5:351-8, 2012
  9. Ibrahim, M., Kostolny, M., Hsia, T. Y., Van Doorn, C., Walker, F., Cullen, S., Yacoub, M. H., Tsang, V. T.: The surgical history, management, and outcomes of subaortic stenosis in adults. Ann Thorac Surg 93:1128-33, 2012
  10. Ibrahim, M., Rao, C., Ashrafian, H., Chaudhry, U., Darzi, A., Athanasiou, T.: Modern management of systolic anterior motion of the mitral valve. Eur J Cardiothorac Surg 41:1260-70, 2012
  11. Ibrahim, M., Navaratnarajah, M., Siedlecka, U., Rao, C., Dias, P., Moshkov, A. V., Gorelik, J., Yacoub, M. H., Terracciano, C. M.: Mechanical unloading reverses transverse tubule remodelling and normalizes local ca(2+)-induced ca(2+)release in a rodent model of heart failure. Eur J Heart Fail 14:571-80, 2012
  12. Ibrahim, M., Rao, C., Athanasiou, T., Yacoub, M. H., Terracciano, C. M.: Mechanical unloading and cell therapy have a synergistic role in the recovery and regeneration of the failing heart. Eur J Cardiothorac Surg 42:312-8, 2012
  13. Ibrahim, M., Ussen, B., Pottle, A., Barbir, M.: Low-density lipoprotein apheresis is effective in reducing lipoprotein(a) levels and in improving symptoms in a patient with refractory angina secondary to accelerated coronary artery disease. J Clin Lipidol 6:192-4, 2012
  14. Torii, R., El-Hamamsy, I., Donya, M., Babu-Narayan, S. V., Ibrahim, M., Kilner, P. J., Mohiaddin, R. H., Xu, X. Y., Yacoub, M. H.: Integrated morphologic and functional assessment of the aortic root after different tissue valve root replacement procedures. J Thorac Cardiovasc Surg 143:1422-8, 2012
  15. Ibrahim, M., Rao, C., Athanasiou, T.: Artificial chordae for degenerative mitral valve disease: Critical analysis of current techniques. Interact Cardiovasc Thorac Surg 15:1019-32, 2012
  16. Ibrahim, M., Terracciano, C., Yacoub, M. H.: Can bridge to recovery help to reveal the secrets of the failing heart? Curr Cardiol Rep 14:392-6, 2012
  17. Ibrahim, M., Kukadia, P., Siedlecka, U., Cartledge, J. E., Navaratnarajah, M., Tokar, S., Van Doorn, C., Tsang, V. T., Gorelik, J., Yacoub, M. H., Terracciano, C. M.: Cardiomyocyte ca2+ handling and structure is regulated by degree and duration of mechanical load variation. J Cell Mol Med 16:2910-8, 2012
  18. Navaratnarajah, M., Ibrahim, M., Siedlecka, U., van Doorn, C., Shah, A., Gandhi, A., Dias, P., Sarathchandra, P., Yacoub, M. H., Terracciano, C. M.: Influence of ivabradine on reverse remodelling during mechanical unloading. Cardiovasc Res 97:230-9, 2013
  19. Ibrahim, M., Navaratnarajah, M., Kukadia, P., Rao, C., Siedlecka, U., Cartledge, J. E., Soppa, G. K., Van Doorn, C., Yacoub, M. H., Terracciano, C. M.: Heterotopic abdominal heart transplantation in rats for functional studies of ventricular unloading. J Surg Res 179:e31-9, 2013
  20. Ibrahim, M., Cartledge, J. E.: Exercise, load and remodelling: Do we know what we think we know? J Physiol 591:2025-6, 2013
  21. Fanshawe, A. E., Ibrahim, M.: The current status of lipoprotein (a) in pregnancy: A literature review. J Cardiol 61:99-106, 2013
  22. Ibrahim, M., Siedlecka, U., Buyandelger, B., Harada, M., Rao, C., Moshkov, A., Bhargava, A., Schneider, M., Yacoub, M. H., Gorelik, J., Knoll, R., Terracciano, C. M.: A critical role for telethonin in regulating t-tubule structure and function in the mammalian heart. Hum Mol Genet 22:372-83, 2013
  23. Ibrahim, M., Terracciano, C. M.: Reversibility of t-tubule remodelling in heart failure: Mechanical load as a dynamic regulator of the t-tubules. Cardiovasc Res 98:225-32, 2013
  24. Torii, R., Ibrahim, M., Mittal, T., Lee, S. L., Yacoub, M. H.: The wide spectrum of aortic root dilatation after the ross operation. Glob Cardiol Sci Pract 2014:49-50, 2014
  25. Ibrahim, M., Fanshawe, A., Patel, V., Goswami, K., Chilvers, G., Ting, M., Pilavakis, Y., Rao, C., Athanasiou, T.: What factors influence british medical students' career intentions? Med Teach 36:1064-72, 2014
  26. Ibrahim, M., Yacoub, M. H.: Bridge to recovery and weaning protocols. Heart Fail Clin 10:S47-55, 2014
  27. Ibrahim, M., Edlin, J. C., Nader, A., Terracciano, C. M.: Recovery of the failing heart: Emerging approaches and mechanisms in excitation-contraction coupling. F1000Prime Rep 6:27, 2014
  28. Candasamy, A. J., Haworth, R. S., Cuello, F., Ibrahim, M., Aravamudhan, S., Kruger, M., Holt, M. R., Terracciano, C. M., Mayr, M., Gautel, M., Avkiran, M.: Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem 289:1282-93, 2014
  29. Ibrahim, M., Rao, C., Savvopoulou, M., Casula, R., Athanasiou, T.: Outcomes of mitral valve repair using artificial chordae. Eur J Cardiothorac Surg 45:593-601, 2014
  30. Chaudhry, U. A., Harling, L., Rao, C., Ashrafian, H., Ibrahim, M., Kokotsakis, J., Casula, R., Athanasiou, T.: Off-pump versus on-pump coronary revascularization: Meta-analysis of mid- and long-term outcomes. Ann Thorac Surg 98:563-72, 2014
  31. Navaratnarajah, M., Siedlecka, U., Ibrahim, M., van Doorn, C., Soppa, G., Gandhi, A., Shah, A., Kukadia, P., Yacoub, M. H., Terracciano, C. M.: Impact of combined clenbuterol and metoprolol therapy on reverse remodelling during mechanical unloading. PLoS One 9:e92909, 2014
  32. Ibrahim, M., Tsang, V. T., Caruana, M., Hughes, M. L., Jenkyns, S., Perdreau, E., Giardini, A., Marek, J.: Cone reconstruction for ebstein's anomaly: Patient outcomes, biventricular function, and cardiopulmonary exercise capacity. J Thorac Cardiovasc Surg 2015    
  1. Navaratnarajah M., Ibrahim M., Yacoub M., Terracciano C.M.: Myocardial Recovery Following Left Ventricular Assist Device Therapy. LVADS, InTech Press
  2. Terracciano C.M., Ibrahim M., Navaratnarajah M., Yacoub M.: Mechano-electric Coupling in Patients treated with Ventricular Assist Devices: insights from individual cases and clinical trials. Cardiac Mechano-Electric Coupling and Arrhythmias, Second Edition, Edited by Kohl P., Sachs F., Franz M. Oxford University Press
  3. Ibrahim M., Vricella L., Tsang V.T.: Truncus Arteriosus. Therapy in Thoracic and Cardiovascular Surgery 2e, Johns Hopkins
  4. Ahmed A., Ibrahim M.:Cardiothoracic Surgery. An Introduction to Surgery for Students, Anthem Press
  5. Ibrahim M., Fanshawe A.: Surgical Research. An Introduction to Surgery for Students, Anthem Press
  6. Fanshawe A., Ibrahim M: A Career in Surgery. An Introduction to Surgery for Students, Anthem Press
  7. Ibrahim M., Nader A., Ryan L.P., Atluri P.: Mitral Valve Disease. Case-based Review of Cardiothoracic Surgery. Editors: Cantu E., Turek J.
  8. Ibrahim M., Heiderich G.M., Cantu E. Cardiac Tumor. Case-based Review of Cardiothoracic Surgery. Editors: Cantu E., Turek J.
  9. Mavroudis C.D., Ibrahim M., Pal J.D. Renal Cell Carcinoma Invading the Inferior Vena Cava. Case-based Review of Cardiothoracic Surgery. Editors: Cantu E., Turek J.
2015 The Isaac Schapera Research Award
2014 Distinctions in Clinical Practice and Clinical Science, Imperial College School of Medicine
2013 National Heart and Lung Institute Thesis Prize
2012 MDU UK Medical Student of the Year (Proxime Accesit)
2012 American Heart Association International Abstract Travel Award
2011 Aswan Heart Center Science and Practice Series, First Prize Oral Presentation
2007 University of Cambridge Travel Award
2006 Medical Research Council Summer Studentship
2003 The Eva Jennings Literary Award (Ranked 1st in UK, English Lit GCSE)

Michael Ibrahim

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