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Christopher D. Blackstock, MD, PhD
Vascular Surgery Direct Resident

 
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Office:
Department of Surgery
4 Maloney
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6156

Contact Information (internal use only)

Christopher.Blackstock@uphs.upenn.edu

 

Christopher is a PGY1 integrated vascular surgery resident. Before attending medical school at Louisiana State University, he completed his PhD in Biomedical Sciences at Tulane University. His graduate research concentrated on elucidating the role of insulin-like growth factor-1 in the cardiovascular system, focusing in the areas of atherosclerosis and vascular regeneration. Christopher remains interested in vascular biology research and plans to pursue a career in academic vascular surgery.

 
Appointments
2017 - present Assistant Instructor in Surgery
 
 
 
 
 
 
 
 
 
Education/Training
2013 - 2017 MD - Louisiana State University School of Medicine - New Orleans
 
2009 - 2013 PhD - Tulane University School of Medicine
 
2008 - 2009 MS - Tulane University School of Medicine
 
2003 - 2007 BS - Florida State University
 
 
 
Memberships/Societies
 
National Societies
2017 - present American College of Surgeons
 
2016 - present Society for Vascular Surgery
 
2013 - present  American Medical Association
 
2012 - present  American Heart Association
 
 
Research
2014 Summer Internship in Human Genetics                                                                           
Tulane University Center for Aging, New Orleans, LA
Primary Advisor:  Czarny-Ratajczak, Malwina, PhD, Assistant Professor of Medicine
 
  • Exome-sequencing to discover novel genes implicated in the pathogenesis of multiple epiphyseal dysplasia and primary osteoarthritis
 
2010 - 2014 PhD Fellowship in Cardiovascular Biology                                                                      
Tulane University Heart and Vascular Institute, New Orleans, LA
Primary Advisor:  Patrice Delafontaine, MD, Chief of Cardiology, Director of Heart and Vascular Institute
Dissertation: Mechanisms Whereby Insulin-like Growth Factor-1 Promotes Atherosclerotic Plaque Stability
 
  • Ex vivo culture of human aortic smooth muscle cells to identify molecular mechanisms whereby insulin-like growth factor-1 (IGF-1) induces increases contractile phenotype and collagen type I synthesis
  • In vivo studies in an apolipoprotein E-knockout (ApoE-/-) mouse model of atherosclerosis to investigate the role of IGF-1 and nitric oxide in the aortic disease
 
2009 - 2010 Cardiovascular Laboratory Research Technician                                                           
Tulane University Heart and Vascular Institute, New Orleans, LA
Primary Advisor:  Patrice Delafontaine, MD, Chief of Cardiology, Director of Heart and Vascular Institute
 
  • Fluorescence-activated cell sorting to determine levels of endothelial progenitor cells in circulation of patients receiving nebivolol vs metoprolol for hypertension, as part of phase IV clinical trial
  • Pilot in vivo studies in ApoE-/- mice to evaluate bone marrow-derived stem cell homing to site of vascular inflammation.
 
2009 Summer Internship in Breast Cancer                                                                              
Louisiana Cancer Research Consortium, New Orleans, LA
Primary Advisor:  Thomas Wiese, Ph.D., Associate Professor of Biochemistry
 
  • miRNA expression profiling (Microarray analysis) in MCF-7 breast cancer cells in response to various endogenous hormones, growth factors, or pharmacologic agents
 
2008 - 2009 Master’s Thesis in Pharmacology                                                                                    
Tulane University Cancer Center, New Orleans, LA
Primary Advisor: Mathew Burow, PhD, Assistant Professor of Medical Oncology
Thesis: Identification of Transcriptionally-Regulated Pathways in the Mechanism of Action of Glyceollin
 
  • Cell culture of MCF-7 breast cancer cells to identify growth inhibitory mechanism of a novel selective estrogen receptor modulator
 
2007 - 2008 Undergraduate Study in Molecular Biophysics                                                               
Florida State University, Dept. of Biophysics, Tallahassee, FL
Primary Advisor: Harry Kroto, PhD, Nobel Prize in Chemistry Laureate (1996)
 
  • Functional assembly of carbon nanotubes to build an electrochemical-sensing scaffold
  • Scanning electron microscopy used to visualize the orientation of carbon nanotubes
 
Publications
  1. Blackstock, C., Higashi, Y., Sukhanov, S., Delafontaine, P.. The Alpha5Beta1 Integrin Mediates Insulin-like Growth Factor-1 Induction of Aortic Smooth Muscle Alpha-Actin Expression Through a PI3K/mTORC2/eIF4E Translational Mechanism. Circulation. 132(Suppl 2): A11552. 2015
  2. Blackstock, C., Eastwood, J., Dasa, V., Czarny-Ratajczak, M.. Next-Generation Sequencing Reveals Novel Genetic Variants Implicated in Multiple Epiphyseal Dysplasia and Primary Osteoarthritis. Journal of Investigative Medicine. 63(2): 483-488. 2015
  3. Blackstock, C., Higashi, Y., Sukhanov, S., Shai, S.Y., Stefanovic, B., Tabony, A.M., Yoshida, T., Delafontaine, P.. Insulin-like Growth Factor-1 Increases Synthesis of Collagen Type I via Induction of LARP6 Expression and Binding to the 5’ Stem-loop of Col1a1 and Col1a2 mRNA. Journal of Biological Chemistry. 289(11): 7264-74. 2014
  4. Blackstock, C., Higashi, Y., Sukhanov, S., Delafontaine, P.. Insulin-Like Growth Factor Increases Collagen Type I and Contractile Protein Expression in Vascular Smooth Muscle: Mechanisms of Atherosclerotic Plaque Stabilization. Circulation. 126(Suppl 2): A16188161-5. 2012
  5. Sukhanov, S., Higashi, Y., Shai, S.Y., Blackstock, C., Galvez, S., Vaughn, C., Titterington, J., Delafontaine, P..  Differential Requirement for Nitric Oxide in IGF-1-induced Anti-apoptotic, Anti-oxidant and Anti-atherosclerotic Effects. FEBS Letters. 585(19): 3065-72. 2011
  6. Kandavar, R., Higashi, Y., Chen, W., Blackstock, C., Vaughn, C., Sukhanov, S., Sander, G.E., Roffidal, L.E., Delafontaine, P., Giles, T.D.. The Effect of Nebivolol Versus Metoprolol Succinate Extended Release on Asymmetric Dimethylarginine in Hypertension. Journal of the American Society of Hypertension. 5(3): 161-5. 2011
 
Awards
2016 SVS Vascular Annual Meeting Medical Student Travel Scholarship
 
2015 ATVB Early Career Investigator Travel Stipend
 
2015 Tinsley Harrison Legacy Scholarship
 
2014 LSUHSC Dean's Award for Biomedical Research
 
2014 Southern Society for Clinical Investigation 1st Place Poster Award for Research
 
2013 Southern Society for Clinical Investigation Travel Stipend
 
2009 Louisiana Cancer Research Consortium 1st Place Poster Award

Christopher Blackstock

 
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