William L. Patrick - Housestaff Profile

Office:
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Telephone: 215-662-6156
Fax: 215-662-7983

Contact Information (internal use only)

William.Patrick@uphs.upenn.edu

Dr. Patrick is a resident in the Cardiac Surgery Direct Residency Program with interest in the surgical treatment of adult and pediatric heart disease. Specific areas of research include adult valvular heart disease and heart failure as well as a variety of congenital pathologies. He plans to pursue a career in academic cardiac surgery.


Appointments
2017 - present	Assistant Instructor in Surgery


Education/Training
2017 - present	Cardiac Direct Surgery Program Hospital of the University of Pennsylvania

2013 - 2017	MD - Stanford University

2008 - 2012	BS - Duke University

Memberships/Societies

Research

2013 – 2017
Stanford University
Research Fellow, Y. Joseph Woo, MD
Investigated angiogenesis in a large animal model of myocardial infarction (MI). Investigated a novel biological nutrient delivery system for cardiomyocyte recovery following MI. Investigated a novel combinatorial therapeutic for cardiomyocyte regeneration and angiogenesis following MI. Analyzed factors that contribute to health outcomes following cardiac surgery in the State of California.

2013 – 2017
Stanford University
Research Fellow, Richard Mainwaring, MD
Investigated institutional surgical outcomes for different congenital cardiac lesions, most notably truncus arteriosus and PA/VSD/MAPCAs. Analyzed the interplay between physiology, anatomy, and surgical approach to provide a better understanding of disease pathophysiology and appropriate treatment.

2012 – 2013
Boston Clinical Research Institute
Research Assistant, C. Michael Gibson, MD
Served as Assistant Editor-In-Chief of wikidoc.org, the world’s largest open source medical textbook (over 150 million views/year). Area of editorial review was congenital cardiac arrhythmias. Constructed a novel educational tool for Google to make medical terms more accessible to patients.

2010-2012
Duke University
Research Assistant, Geoffrey Pitt, MD
Investigated novel genetic predictors of sudden cardiac death. Identified novel mutations associated with long QT syndrome.

2008 – 2010
University of North Carolina – Chapel Hill
Research Assistant, Joseph DeSimone, PhD
Designed and fabricated nanoparticles using the PRINT technology for the inhaled delivery of pulmonary drugs.

Publications

Original Papers

Cohen JE, Goldstone AB, Paulsen MJ, Shudo Y, Steele AN, Edwards BB, et al. An innovative biologic system for photon-powered myocardium in the ischemic heart. Science Advances. 2017;3.
Ibrahimiye AN, Mainwaring RD, Patrick WL, Downey L, Yarlagadda V, and Hanley FL. Left Ventricular Re-training and Double Switch in Patients With Congenitally Corrected Transposition of the Great Arteries. World J. For Pediatric and Congenit Heart Surg. 2017; 8(2) 203-209.
Goldstone AB, Patrick WL, Bilbao MS, Woo YJ. Minimally invasive mitral valve repair in situs inversus totalis. J Card Surg. 2016;31(12):718-720. doi:10.1111/jocs.12859.
Mainwaring RD, Patrick WL, Carrillo SA, Ibrahimye AN, Muralidaran A, Hanley FL. Prevalence and Anatomy of Retroesophageal Major Aortopulmonary Collateral Arteries. The Annals of Thoracic Surgery. 2016;102(3):877-882. doi:10.1016/j.athoracsur.2016.03.011.
Patrick WL, Mainwaring RD, Carrillo SA, et al. Anatomic Factors Associated With Truncal Valve Insufficiency and the Need for Truncal Valve Repair. World J Pediatr Congenit Heart Surg. 2016;7(1):9-15. doi:10.1177/2150135115608093.
Cohen JE, Goldstone AB, Shudo Y. A Novel Minimally Invasive Ovine Model of Ischemic Cardiomyopathy With Advanced Cardiac Imaging Yields Superior Results and Survival. The Journal of Heart 2015.
Goldstone AB, Patrick WL, Cohen JE, Aribeana CN, Popat R, Woo YJ. Early surgical intervention or watchful waiting for the management of asymptomatic mitral regurgitation: a systematic review and meta-analysis. Ann Cardiothorac Surg. 2015;4(3):220-229. doi:10.3978/j.issn.2225-319X.2015.04.01.
Carrillo SA, Mainwaring RD, Patrick WL, et al. Surgical Repair of Pulmonary Atresia With Ventricular Septal Defect and Major Aortopulmonary Collaterals With Absent Intrapericardial Pulmonary Arteries. The Annals of Thoracic Surgery. 2015;100(2):606-614. doi:10.1016/j.athoracsur.2015.03.110.
Mainwaring RD, Patrick WL, Punn R, Palmon M, Reddy VM, Hanley FL. Fate of right ventricle to pulmonary artery conduits after complete repair of pulmonary atresia and major aortopulmonary collaterals. The Annals of Thoracic Surgery. 2015;99(5):1685-1691. doi:10.1016/j.athoracsur.2014.12.071.
Hennessey JA, Boczek NJ, Jiang YH, Miller JD. A CACNA1C variant associated with reduced voltage-dependent inactivation, increased Ca V 1.2 channel window current, and arrhythmogenesis. PLoS ONE 2014. doi:10.1371/journal.pone.0106982.
Hennessey JA, Jiang Y, Miller JD, Stadt HA, Patrick W. A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates. Heart Rhythm. 2013. doi:10.1016/j.hrthm.2013.09.026.

Abstracts

Greene, C.L., Mainwaring, R.D., Sidell, D., Yarlagadda, V., Patrick, W.L., Hanley, F.L.: Impact of Phrenic Nerve Palsy and Need for Diaphragm Plication Following Surgery for Pulmonary Atresia with Ventricular Septal Defect and Major Aortopulmonary Collaterals. WTSA, June 21-24, 2017, Colorado Springs, CO.
Patrick, W.L., Goldstone, A.B., Chiu, P., Paulsen, M.J., Lingala, B., Baiocchi M., Woo, Y.J.: Long-Term Outcomes of Aortic Valve Replacement in Adults £40 Years Old: An Analysis of 1478 Patients in 136 Hospitals in the State of California. WTSA, June 21-24, 2017, Colorado Springs, CO.
Mainwaring, R.D., Patrick, W.L., Roth, S., Komra, K., Wise-Faberowski, L., Palmon, M., Hanley F.L.: Surgical Algorithm and Results for Repair of Pulmonary Atresia/Ventricular Septal Defect/Major Aortopulmonary Collaterals. AATS, April 29-May 3, 2017, Boston, MA.
Goldstone, A.B., Patrick, W.L., Chiu, P., Paulson, M.J., Lingala, B., Baiocchi, M., Woo, Y.J.: Long-Term Effects of Prosthesis Selection in Young Adults Undergoing Mitral Valve Replacement in the State of California AATS, April 29-May 3, 2017, Boston, MA.

Editorials, Reviews, Chapters

Patrick WL, Patel C, Guddeti R, et al. Is there a need for “triple therapy?” Role of anticoagulation with dual antiplatelet therapy in acute coronary syndromes (ATLAS Study & TRAP Study). Curr Cardiol Rep. 2013;15(10):411. doi:10.1007/s11886-013-0411-1.

Patents

”Engineered Aerosol particles, and Associated Methods”. Application No. 13/383,518 filed January 11, 2012; Publication number US20120114554 A1. Note: Serves as the foundation of the company Liquidia Technologies, Inc.


Awards
2016	George R. Daicoff President’s Award. Southern Thoracic Surgical Association

2014	Medical Scholars Research Program funding award. Stanford University School of Medicine

2012	Graduation with Distinction. Duke University

2011	NPR Fellowship. Duke Institute for Brain Sciences

2008	Eagle Scout Award. Boy Scouts of America

2007	Congressional Award Gold Medalist. United States Congress